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Phellinus igniarius

Phellinus igniarius is a perennial bracket fungus belonging to the family Hymenochaetaceae, commonly known as the willow bracket, false tinder polypore, or fire sponge. It is characterized by tough, hoof-shaped fruiting bodies that measure up to 40 cm across and 20 cm thick, with a initially pale upper surface that darkens to grey-black and cracked with age, and a porous underside featuring 4-6 pores per millimeter. This wood-decay species primarily causes white rot in the heartwood of hardwoods, decomposing lignin, cellulose, and hemicelluloses through enzymatic action.^[1]^[2]^[3] Taxonomically, Phellinus igniarius is classified within the kingdom Fungi, phylum Basidiomycota, class Agaricomycetes, order Hymenochaetales, and family Hymenochaetaceae, with synonyms including Fomes igniarius and Phellinus trivialis. Originally described as Boletus igniarius by Linnaeus in 1753, it was reclassified by Quélet in 1886.^[4] The fungus reproduces via basidiospores released from its tubes during summer and autumn, and it forms intersterility groups that influence mating compatibility. Its fruiting bodies are perennial, persisting for years on infected hosts, and exhibit no significant odor or taste.^[5]^[1]^[6] Ecologically, Phellinus igniarius acts as both a parasite on living trees and a saprobe on dead wood, primarily targeting deciduous species such as willows (Salix spp.), birches (Betula spp.), maples (Acer spp.), alders (Alnus spp.), and oaks (Quercus spp.), though it can infect over 20 hardwood genera in North America. Infection often begins through wounds, leading to yellow-white decay with black zone lines and cankers, which can extend decay columns up to 3-5 meters in height, weakening trees and contributing to cull logs in forests. It plays a role in nutrient cycling by breaking down woody debris but is considered a pathogen in managed woodlands, occasionally associating with diseases like esca in grapevines.^[2]^[6]^[3] Distributed across the Northern Hemisphere, Phellinus igniarius is widespread in Europe, North America (including all Canadian provinces and parts of the United States like Indiana and Montana), and Asia, favoring temperate forests and urban parklands where suitable hosts grow. In Canada, it is particularly common in British Columbia on species like cottonwood and dogwood. While not globally threatened (rated as secure in Canada), its presence can impact timber quality, and historical uses include employing the dry fruiting bodies as tinder due to their flammable properties. Recent research highlights potential medicinal applications from its polysaccharides, which exhibit antioxidant and immunomodulatory effects, though further studies are needed.^[5]^[6]^[2]^[3]

Taxonomy

Etymology and nomenclature

The genus name Phellinus derives from the Ancient Greek word phellos, meaning "cork," alluding to the tough, cork-like texture of the fruiting bodies in species of this genus.^[7] The specific epithet igniarius originates from the Latin ignis, meaning "fire," reflecting the historical use of the fungus as tinder due to its flammable dried interior.^[8]^[9] Common names for Phellinus igniarius include willow bracket, fire sponge, false tinder polypore, and false tinder conk, with the latter emphasizing its role in fire-starting traditions.^[10]^[11] These names often highlight its preferred association with willow trees or its combustibility. The species was first described by Carl Linnaeus as Boletus igniarius in his 1753 work Species Plantarum.^[12] It was later transferred to the genus Phellinus by Lucien Quélet in 1886, establishing the current binomial Phellinus igniarius (L.) Quél.^[12]^[6] Under the International Code of Nomenclature for algae, fungi, and plants (ICN), Phellinus igniarius is the accepted name, with no significant recent controversies, though the broader Phellinus igniarius group has presented taxonomic challenges due to morphological similarities among related species.^[12]^[6]

Synonyms and classification

Phellinus igniarius belongs to the kingdom Fungi, division Basidiomycota, class Agaricomycetes, order Hymenochaetales, family Hymenochaetaceae, genus Phellinus, and species P. igniarius (L.) Quél.^[13] This taxonomic placement reflects its position as a wood-decaying basidiomycete within the Hymenochaetaceae, a family characterized by poroid hymenochaetoid fungi.^[6] The species has several synonyms, including Fomes igniarius (L.) Cooke and Phellinus trivialis (Bres.) Kreisel.^[6]^[14] These synonyms arise from historical classifications that placed the fungus in genera like Fomes before its reassignment to Phellinus based on morphological and molecular evidence.^[5] Phylogenetically, P. igniarius is part of the well-supported Phellinus sensu stricto (s.s.) clade within the Hymenochaetaceae family.^[15] Molecular studies using internal transcribed spacer (ITS) regions and other markers, such as translation elongation factor 1-alpha (tef1α), have confirmed its separation from related genera like Fomitiporia, which were previously lumped in broader Phellinus sensu lato (s.l.) groupings.^[16]^[17] These analyses highlight the monophyly of Phellinus s.s. and its distinct evolutionary lineage among hymenochaetoid fungi.^[6] Recent taxonomic revisions have established P. igniarius as a species complex comprising at least 15 distinct species worldwide, with no major further splits documented since the widespread adoption of DNA barcoding in the 2000s.^[15] The strict sense (P. igniarius s.s.) is now limited primarily to hosts in the genus Salix (willows), particularly in Europe and Asia, while morphologically similar taxa on other hardwoods represent separate species.^[16] This delimitation relies on multilocus phylogenies, including ITS sequencing, which reveal cryptic diversity and host-specific adaptations within the complex.^[17]

Description

Macroscopic features

Phellinus igniarius produces perennial bracket-like fruiting bodies that are typically hoof- or disc-shaped, measuring 5–40 cm in width and 2–20 cm in thickness at the base, with lateral attachment to the host substrate. These structures are woody and hard, emerging from the bark or wood of trees, and can develop over multiple years, adding new growth layers annually.^[1] The upper surface is crusty and zonate, featuring concentric ridges that mark annual growth increments, sometimes accumulating up to 80 layers in older specimens; coloration ranges from dark gray to black or brown, with a velvety brown margin on younger growth and a rough, cracked texture in mature examples.^[1] The pore surface is grayish-brown, with 4–6 circular to angular pores per millimeter; the internal context is woody-hard and cinnamon- to reddish-brown. The fungus exhibits no significant odor or taste and is inedible due to its extreme toughness. Growth occurs solitarily or in overlapping clusters, with fruiting bodies persisting for 5–20 years.^[1]

Microscopic characteristics

The hyphal system of Phellinus igniarius is trimitic, comprising generative hyphae that are hyaline, thin-walled, clamp-bearing, and 2–3 µm in diameter; skeletal hyphae that are thick-walled, golden-brown, aseptate, and 4–6 µm in diameter; and binding hyphae that are thick-walled and branched.^[6]^[18] Basidia are clavate, measuring 15–25 × 4–6 µm, and each produces four sterigmata.^[6] Basidiospores are broadly ovoid to subglobose, 4–5.5 × 2.5–3.5 µm, hyaline, thick-walled, and non-amyloid.^[19]^[20] The fungus lacks true cystidia, but the pores are lined with metuloid cystidioles that are thick-walled and pointed. Diagnostic microscopy reveals no reaction when stained with Melzer's reagent.^[6]

Distribution and habitat

Geographic range

Phellinus igniarius sensu lato (including the species complex) is native to the Holarctic region, with a widespread distribution across the northern hemisphere. Recent phylogenetic studies recognize a complex of about 15 cryptic species within the traditional P. igniarius, with the strict species primarily in Europe and Asia, while North American populations represent distinct taxa.^[21]^[16] In Europe, it occurs from Scandinavia, including countries such as Norway, Sweden, and Finland, extending southward to the Mediterranean region, encompassing nations like Spain, Italy, Greece, and Cyprus.^[22] In North America, the fungus ranges from northern territories like Alaska and Yukon in Canada to southern areas including Mexico, with records across multiple Canadian provinces (Alberta, British Columbia, Labrador, Manitoba, New Brunswick, Newfoundland, Nova Scotia, Northwest Territories, Saskatchewan) and U.S. states (Indiana, Montana).^[5]^[22] In Asia, it is documented in Russia (including Central, Eastern, Far East, Northern, Southern, and Western Siberia regions), China (Heilongjiang, Jilin, Xinjiang provinces), Japan, Kazakhstan, Turkey, and Uzbekistan.^[22] Reports indicate introductions or expansions beyond the native range, particularly in the southern hemisphere, likely facilitated by international trade of host materials. For instance, occurrences have been noted in New Zealand, where specimens are preserved in the national fungarium, and in southern South America, such as Argentina and Venezuela. Additional records exist in parts of Africa (Eritrea, Ethiopia, Libya, Madagascar, Zambia), Central America (Nicaragua), and Oceania (Australia in Queensland, Papua New Guinea), though these may reflect sporadic introductions rather than established populations.^[22] The fungus thrives in temperate to boreal forest environments and shows a preference for moist, riparian zones where humidity supports its development on suitable substrates. It is commonly associated with broadleaf trees in these settings.^[16] Phellinus igniarius is abundant in northern latitudes, where it is a frequent component of forest ecosystems, but becomes less prevalent in warmer, subtropical climates due to unsuitable conditions.^[23] Its populations remain stable globally, with no conservation concerns identified, as reflected in its secure status (N5) in Canada and no rank (GNR) overall.^[5]

Host preferences

Phellinus igniarius primarily colonizes deciduous hardwoods, with a strong preference for species in the genera Salix (willows), Betula (birches), Alnus (alders), Populus (poplars), Fagus (beeches), and Acer (maples).^[2]^[6]^[24] The fungus exhibits high substrate specificity, favoring angiosperms over gymnosperms and only rarely infecting conifers.^[25] It targets the heartwood, inducing white rot that weakens the structural integrity of the host.^[6]^[26] Infection typically occurs through wounds, including branch stubs, pruning cuts, frost cracks, or other injuries on trunks, branches, or roots, allowing basidiospores to germinate and colonize the wood.^[27]^[6]^[26] As a perennial species, P. igniarius persists on both living trees and dead wood, forming long-lasting brackets that enable repeated spore production over multiple seasons.^[6]^[27] Host preferences show regional variation: in North America, it is more commonly associated with Populus species such as quaking aspen (Populus tremuloides) and eastern cottonwood (Populus deltoides), while in Europe, Salix species dominate as primary hosts, with birch and alder also frequent.^[28]^[24]^[11]^[6]^[29]

Ecology

Life cycle

Phellinus igniarius reproduces primarily through sexual means via basidiospores produced on the hymenial surface of its perennial fruiting bodies, which are hoof- or bracket-shaped and emerge from wounds or branch stubs on host trees.^[3] These spores, measuring 5–6.5 × 4.5–6 μm with thick walls, are released mainly from late summer through autumn, coinciding with periods of high moisture that facilitate dispersal by wind and rain, though dry conditions suppress release.^[30]^[31] Despite their small size enabling potential long-distance travel, spore viability is limited, with sensitivity to sunlight reducing the half-life to about 22.6 hours under exposure and freezing at -25°C severely inhibiting germination.^[30] Upon landing on suitable substrates such as wounded bark or aged branch stubs—where host defenses are diminished—the basidiospores germinate under optimal conditions of darkness, 20–24°C, and neutral to slightly acidic pH, forming monokaryotic hyphae that initially grow superficially before penetrating the wood.^[3] The resulting mycelium is dimitic, comprising clamp connection-absent generative hyphae (hyaline, thin-walled, 2–4 μm wide) and thick-walled skeletal hyphae (brown, up to 10 μm wide), which colonize the heartwood and establish a persistent infection.^[6] Homokaryotic and heterokaryotic mycelial phases occur, with the latter dominating through nuclear fusion after compatible mating, enabling dikaryotic growth.^[6] The mycelium persists perennially within the host for years to decades, slowly expanding decay columns that can reach 3–5 m in length, while the fungus remains latent until environmental cues prompt basidiocarp initiation.^[3] Fruiting bodies develop at wound sites, adding a new fertile pore layer annually to the underside, which produces successive generations of spores; this layered growth reflects the fungus's long-term occupation of the substrate.^[3] Asexual reproduction via mycelial fragments or conidia is uncommon and plays a minor role compared to basidiospore-mediated spread.^[32] The complete life cycle from spore germination and infection to initial fruiting body formation spans a multi-year process, typically several years, after which the perennial phase sustains spore production indefinitely on the living or dead host.^[3]

Pathogenic effects

_Phellinus igniarius is a white-rot fungus that primarily affects the heartwood of hardwood trees, decomposing both lignin and cellulose through the action of extracellular ligninolytic enzymes such as laccase and manganese peroxidase.^[6]^[33] These enzymes enable the fungus to break down the structural components of wood, resulting in a fibrous, pale, and progressively softened texture that develops over several years.^[34] In advanced stages, the decay often features fine black zone lines within the yellow-white wood, distinguishing it from other rot types.^[2] The infection typically initiates through wounds, branch stumps, frost cracks, or other natural openings in the bark, allowing basidiospores or mycelium to enter and colonize the heartwood.^[35] From there, the mycelium spreads slowly, often at rates of centimeters per year, primarily remaining latent in the heartwood but occasionally invading the sapwood and causing further structural compromise.^[6] Visible symptoms include the formation of perennial, hoof-shaped fruiting bodies (brackets) on the trunk or branches, which emerge as hard, woody structures with a grey-black upper surface and a brown, porous underside; these brackets indicate significant internal decay.^[2] Affected trees exhibit overall weakening, increased susceptibility to wind breakage, and potential girdling if the decay encircles the trunk, though the fungus rarely kills the host outright.^[35] Economically, P. igniarius has a minor impact in most forestry contexts, as it is less aggressive than pathogens like Armillaria species, but it reduces timber and pulp quality in affected hardwoods such as birch and willow.^[2] Notable damage occurs in urban settings and Northern European plantations, particularly on willows (Salix spp.), where decayed trees pose hazards in recreational areas and require removal.^[6] Additionally, the decay creates softened wood that attracts woodpeckers and facilitates secondary colonization by insects, indirectly supporting biodiversity through habitat provision in deadwood.^[35]

Identification

Distinguishing features

Phellinus igniarius exhibits a distinctive hoof-shaped bracket fruiting body, typically measuring 10-20 cm wide and up to 20 cm thick, with a dark, crusty exterior that often appears blackened and cracked, featuring prominent zoned growth rings indicative of its perennial nature. This hard, persistent structure adheres firmly to the host tree, lacking any stem except in very young specimens, and maintains a woody consistency that endures for many years.^[1]^[25] The fertile underside bears small, circular pores, numbering 4-6 per millimeter, which are initially pale cream to brown and darken to rusty or cinnamon hues with age, without any color change upon bruising or handling. In cross-section, the context reveals a firm, non-crumbling, reddish-brown to woody interior divided into distinct annual layers, contributing to its overall toughness. A bitter taste is characteristic when sampled, further aiding in identification.^[1]^[25]^[11] Fruiting primarily occurs in the fall, with spore release extending through summer and autumn, and the fungus shows no gelatinous or strictly annual variants, reinforcing its identification through seasonal and textural cues. Its hard texture allows differentiation from softer polypores via a simple firmness test. The spore print is white.^[1]

Similar species

Phellinus igniarius can be confused with several morphologically similar polypores in the Hymenochaetaceae family, particularly other species in the Phellinus igniarius complex, which are distinguished primarily by host specificity, pore density, and context coloration. Accurate identification often requires consideration of the associated tree species, as many of these fungi exhibit strict host preferences, supplemented by microscopic examination of hyphal structure and setae.^[36] Phellinus tremulae, commonly known as the aspen bracket, is one of the closest relatives and is nearly identical in overall form and texture to P. igniarius, but it is restricted to Populus species such as aspen and poplar, whereas P. igniarius primarily occurs on Salix. The pore surface of P. tremulae is slightly darker tawny to purplish brown and features larger pores measuring 3–5 per mm, compared to the 4–6 per mm in P. igniarius; additionally, the context tissue in P. tremulae tends to be yellower. Microscopic analysis reveals subtle differences in marginal chlamydospore shape, confirming the distinction.^[37]^[36] Phellinus pomaceus, commonly known as the cushion bracket, produces smaller brackets, typically up to 8 cm across, with more pronounced orange hues in the young upper surface and margin, maturing to darker brown and cracked; it grows on hardwoods such as Prunus species. Its pores are angular and measure 3–4 per mm, with a pale tan to orange-tan coloration, and the context is distinctly orange-brown, up to 2 cm thick. Host association with fruit trees like plum further aids differentiation.^[38] Fulvifomes robiniae, formerly classified as Phellinus robiniae, occurs exclusively on Robinia pseudoacacia (black locust) and can form resupinate patches or hoof-shaped brackets with a tomentose yellow-brown upper surface that cracks and darkens to black with age. Its pores are brown and 7-8 per mm, and while morphologically similar, phylogenetic analyses place it outside the core Phellinus clade, with differences in setal morphology visible under microscopy. The strict host limitation to locust trees provides a key field differentiator from the broader deciduous host range of P. igniarius.^[39] Species in the genus Fomitiporia, such as F. robusta, resemble P. igniarius in bracket form but are generally thinner and perennial, with tubes that separate more easily from the context upon maturation. These fungi occur on broad-leaved trees like oak, and their spores exhibit stronger dextrinoid reactions in microscopy compared to the weakly dextrinoid or non-reactive spores of P. igniarius. Pore density is similar (4–6 per mm), but the overall perennial, woody structure of P. igniarius contrasts with the more fragile, layered growth in Fomitiporia.^[36]^[37] Phellinus arctostaphyli is smaller in size, with brackets rarely exceeding 10 cm, and is confined to hosts in the Ericaceae such as Arctostaphylos (manzanita) and Ceanothus, primarily in western North America including northern regions. Its upper surface is smoother and less cracked than that of P. igniarius, with a context that is paler and less zonate; pores are comparable in density (4–5 per mm) but the overall compact form and host specificity distinguish it. Microscopic features, including hyphal arrangement, provide final confirmation. Overall, differentiation among these species relies heavily on host tree identification, followed by pore density (e.g., fewer and larger in P. tremulae and F. robiniae) and context hues, with microscopy essential for resolving ambiguous cases due to overlapping macroscopic traits.^[36]^[37]

Uses

Traditional applications

Phellinus igniarius has been utilized historically as a tinder material due to the slow-burning properties of its dried interior, earning it the common name false tinder polypore. In Europe, the fungus was processed into a soft, velvety substance known as esca or amadou, which caught sparks effectively from flint and steel kits and maintained a smolder without open flame, facilitating fire transport and starting since prehistoric times.^[40] This woody, corky texture allowed it to serve as reliable kindling in survival contexts across temperate regions.^[40] In Scandinavia, including among the Sami people, P. igniarius was employed for fire-making, with locals preparing it into tinder for traditional ignition methods.^[41] The species was referenced in 18th-century botanical texts, such as those by Carl Linnaeus, who named it Boletus igniarius in recognition of its fire-starting utility.^[1] North American indigenous groups adapted the fungus for practical crafting beyond fire use. In Alaska, the Inupiaq and Yup'ik peoples burned the basidiocarps to produce ashes, which were mixed with tobacco for smoking or chewing to enhance its effect, a practice documented for centuries and evidenced by ornate storage boxes from the late 1800s.^[41]

Medicinal properties

In traditional East Asian medicine, particularly in China and Korea, Phellinus igniarius (known as "Sanghuang") has been used for centuries to treat conditions such as diarrhea, stomach and intestinal ailments, hemorrhages, and inflammation, often prepared as decoctions from the fruiting body.^[42]^[43] The mushroom contains bioactive compounds including polysaccharides, hispidin, and hispolon, which contribute to its antioxidant and anti-inflammatory properties.^[44]^[45]^[46] Polysaccharides exhibit strong free radical scavenging activity, while hispidin and hispolon demonstrate inhibitory effects on oxidative stress and inflammatory pathways in cellular models.^[47]^[48] A 2014 study in a mouse model of experimental autoimmune encephalomyelitis, an analogue for multiple sclerosis, showed that an extract termed Piwep from P. igniarius reduced disease severity by inhibiting immune cell infiltration into the spinal cord, suggesting potential symptom relief through immunomodulation.^[49] In 2022 research using hyperuricemic and gouty rats, both wild and cultivated P. igniarius extracts lowered serum uric acid levels by inhibiting xanthine oxidase activity and downregulating urate transporter expression, alleviating gouty inflammation.^[50] A 2016 review highlighted the antitumor activity of P. igniarius extracts in vitro, demonstrating inhibition of gastric cancer cell lines via mitochondria-dependent apoptosis pathways.^[45]^[51] Additional pharmacological effects include immunomodulatory actions, such as restoring CD4+/CD8+ T cell ratios and cytokine balance in immune-deficient models, hepatoprotective benefits by activating farnesoid X receptor signaling to mitigate liver injury, and potential anti-diabetic properties through modulation of gut microbiota and improved glucose tolerance in type 2 diabetes mouse models during the 2020s. A 2024 study demonstrated hypoglycemic effects of P. igniarius through serum metabolome analysis in type 2 diabetes models.^[52] Additionally, a 2025 pharmacokinetic study profiled twelve compounds from P. igniarius extracts, confirming their absorption and distribution.^[53]^[54]^[55]^[56] Studies report low toxicity for P. igniarius extracts, with doses up to 3 mg/g showing minimal adverse effects in animal models, though human clinical trials remain limited, highlighting gaps in translating preclinical findings to therapeutic applications.^[46]^[57]

References

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... Names of Plants. 210. Page 221. igniarius -a -um burning, igneus (Phellinus igniarius is black, cracked and reddish edged) ignivolvatus -a -um having a flame ...
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Position in classification: Hymenochaetaceae, Hymenochaetales, Agaricomycetidae, Agaricomycetes, Agaricomycotina, Basidiomycota, Fungi
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While ITS sequences demonstrated an ability to differentiate most Phellinus s.s. species, this dataset also exhibited high intraspecific variation. For example, ...
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Aug 6, 2025 · A phylogeny based on a combined dataset of ITS and nLSU sequences for accepted genera of Hymenochaetaceae was analyzed and two or multigene ...
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The microscopy of P. nigrolimitatus was revised. The species turned out to differ enough to be separated into a new genus, Phellopilus Niemelä, Wagner &.
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### Distinguishing Features of Phellinus igniarius
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[41]
Traditional uses, fermentation, phytochemistry and pharmacology of ...
As a traditional Chinese medicine with a 2000-year long history, medicinal applications of Phellinus linteus mainly include treating hemorrhage, hemostasis and ...Missing: Linnaeus | Show results with:Linnaeus
[42]
Review Recent advances in the bioactive polysaccharides and other ...
Phellinus igniarius is a valuable medicinal and edible mushroom, and its polysaccharides exhibit excellent anti-inflammatory activity. During liquid ...
[43]
Phellinus igniarius: A Pharmacologically Active Polypore Mushroom
Mushrooms have been widely used in traditional medicine for the treatment of various diseases. Today, their therapeutic value is scientifically studied and.Missing: paper | Show results with:paper
[44]
Screening for proteins related to the biosynthesis of hispidin and its ...
Mar 12, 2021 · Phellinus igniarius, the most common source of HIP, can be used as both medicine and food. However, the biosynthetic pathway of HIP in P.Missing: trigger | Show results with:trigger
[45]
Antioxidant activity of Phellinus igniarius fermentation mycelia ...
Jan 15, 2024 · Phellinus spp. have historically been used as traditional medicines to treat various diseases owing to their antioxidant, antitumor, ...
[46]
Antioxidative and anti-inflammatory effect of Phellinus igniarius on ...
Feb 25, 2019 · This study investigated the antioxidative and anti-inflammatory effect of Phellinus igniarius (PI) on RAW264.7 mouse macrophages.
[47]
A Mushroom Extract Piwep from Phellinus igniarius Ameliorates ...
The present study aimed to evaluate the therapeutic potential of a mushroom extract from Phellinus igniarius in an animal model of multiple sclerosis.
[48]
Anti-Gout Effects of the Medicinal Fungus Phellinus igniarius in ...
Jan 11, 2022 · Wild P. igniarius and cultivated P. igniarius showed similar activities in reducing uric acid levels through inhibiting XO activity and down- ...
[49]
Medicinal mushroom Phellinus igniarius induced cell apoptosis in ...
Phellinus igniarius is a traditional medicinal mushroom used in China and other countries of East Asia for the treatment of various diseases including cancer.Missing: Linnaeus historical
[50]
Phellinus igniarius alcohol extract restores the immune homeostasis ...
This study found that Phellinus igniarius alcohol extract could increase the ratio of CD4+/CD8+ T cells, improve the level of cytokines secretion, and rebuild ...Missing: properties | Show results with:properties
[51]
Metabolomics study of the hepatoprotective effect of Phellinus ...
The present study for the first time systematically illustrated the hepatoprotective effect of P. igniarius and preliminarily explored its potential target FXR.Missing: process | Show results with:process
[52]
Phellinus igniarius Polysaccharides Ameliorate Hyperglycemia by ...
Oct 17, 2023 · Recent studies have demonstrated that active polysaccharides can improve T2DM by regulating the composition of intestinal microbiota and the ...
[53]
Isolation Techniques, Structural Characteristics, and ... - MDPI
Phellinus is known to produce polysaccharides with significant antitumor activity, achieving a tumor inhibition rate of 96.7 % [63]. The primary mechanism of ...