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Retinyl acetate

Retinyl acetate, also known as retinol acetate or vitamin A acetate, is an ester derivative of retinol (vitamin A) formed by the esterification of retinol with acetic acid, serving as an essential micronutrient for human health.^[1] It has the molecular formula C₂₂H₃₂O₂ and a molecular weight of 328.49 g/mol, typically appearing as a light yellow to dark yellow viscous liquid or solid with a melting point of 51–58 °C.^[2]^[1] As a fat-soluble compound, it is soluble in organic solvents like ethanol, chloroform, and ethyl acetate but has limited solubility in water, and it is sensitive to light and air, requiring storage at -20 °C under inert conditions to maintain stability.^[2]^[1] In biological systems, retinyl acetate acts as a precursor to retinol and retinoic acid, supporting key physiological functions such as vision (particularly night vision through rhodopsin formation), epithelial cell growth and differentiation, immune response, and reproduction.^[3] It is commonly used as a dietary supplement to prevent and treat vitamin A deficiency, with potency standardized at approximately 2,800,000 international units (IU) per gram, and is incorporated into fortified foods, multivitamins, and animal feeds.^[2]^[1] In cosmetics and dermatology, it is a mild topical retinoid applied in anti-aging formulations to promote collagen production, reduce wrinkles, improve skin elasticity, and treat hyperpigmentation, though it is less irritating than retinoic acid but requires conversion in the skin for full activity.^[4] Medically, retinyl acetate exhibits potential antineoplastic and chemopreventive properties, with studies exploring its role in treating conditions like cervical intraepithelial neoplasia through intravaginal application and in cell culture media for mammalian growth.^[1]^[4] However, excessive intake can lead to hypervitaminosis A, causing toxicity symptoms such as liver damage, birth defects, and skin irritation, necessitating careful dosing—recommended daily allowances are 700–900 μg retinol activity equivalents (RAE) for adults, with upper limits at 3,000 μg RAE to avoid adverse effects.^[3]

Chemical Properties

Molecular Structure

Retinyl acetate possesses the chemical formula C_{22}H_{32}O_{2} and a molecular weight of 328.49 g/mol.^[5]^[6] This compound is the acetate ester of all-trans-retinol, formed through the esterification of the hydroxyl group on retinol with acetic acid. Its core structure features a β-ionone ring—a cyclohexene ring with geminal methyl groups and a methyl substituent—attached to an 11-carbon polyene side chain containing four conjugated double bonds in the all-trans configuration. The acetate moiety (-OCOCH_{3}) is linked via an ester bond at the terminal C-15 position of the polyene chain, enhancing its stability compared to the parent alcohol while maintaining the conjugated system responsible for its biological activity.^[5]^[7] The predominant form of retinyl acetate is the all-trans isomer, where all exocyclic double bonds exhibit E geometry; cis isomers, such as 13-cis or 9-cis variants, exist but are less common in commercial preparations and differ in the configuration around specific double bonds in the polyene chain.^[5] In comparison to related retinoids, retinyl acetate differs from retinol by the replacement of the free hydroxyl (-OH) group at C-15 with an acetate ester, and from retinyl palmitate by having a shorter two-carbon acetyl chain instead of the 16-carbon palmitoyl ester, which affects lipophilicity and solubility.^[5]^[8]

Physical and Chemical Characteristics

Retinyl acetate is a light yellow to yellow crystalline solid at room temperature, often appearing as greasy or sticky prisms with a mild characteristic odor.^[9] It melts at 57-58°C and has a density of approximately 0.98 g/cm³ at 25°C. The compound decomposes upon heating above 230°C without a defined boiling point, as it is thermally unstable under such conditions. Retinyl acetate exhibits low solubility in water, with values below 0.1 mg/mL, rendering it practically insoluble in aqueous environments.^[9] In contrast, it is highly soluble in fats and oils (up to 750 g/100 mL) as well as in organic solvents such as ethanol, chloroform, acetone, and isopropanol, reflecting its lipophilic nature. Chemically, retinyl acetate is sensitive to light, heat, oxygen, and alkaline conditions, which can induce isomerization or oxidative degradation, though the acetate ester provides greater stability compared to free retinol. It remains relatively stable in neutral to slightly acidic pH environments but undergoes bond rearrangement in strong acids or bases.^[10] The compound displays a characteristic ultraviolet absorption maximum at 325 nm in ethanol, facilitating its identification and quantitative analysis in spectroscopic methods. This absorption arises from the conjugated polyene system in its structure, contributing to its photosensitivity.^[11]

Biological Role

Metabolism

Retinyl acetate, a common dietary form of vitamin A, is primarily absorbed in the small intestine, where it undergoes hydrolysis by pancreatic enzymes such as carboxylester lipase and intestinal brush border esterases to yield free retinol prior to cellular uptake.^[12] This process is facilitated by micelle formation with dietary lipids, enabling the retinyl ester to interact with the intestinal mucosa; approximately 70-90% of ingested retinyl esters are absorbed under normal conditions.^[13] Once inside enterocytes, the free retinol is re-esterified primarily by lecithin:retinol acyltransferase (LRAT) into retinyl esters, which are then incorporated into chylomicrons for lymphatic transport to the bloodstream and delivery to the liver.^[12] Following absorption, retinyl esters are transported to the liver via chylomicron remnants, where they are stored or mobilized for systemic distribution. In the liver, these esters accumulate in hepatic stellate cells as lipid droplets, comprising 70-90% of total body vitamin A reserves, again mediated by LRAT.^[12] For circulation, stored retinyl esters are hydrolyzed by retinyl ester hydrolases (such as hormone-sensitive lipase) to retinol, which binds to retinol-binding protein 4 (RBP4) in hepatocytes and forms a complex with transthyretin to prevent renal filtration and ensure delivery to peripheral tissues.^[12] This holo-RBP complex maintains plasma retinol levels at 2-4 μM in humans during fasting states.^[12] Excretion of retinyl acetate-derived vitamin A is limited, with minimal urinary loss due to the RBP-transthyretin binding; instead, excess is primarily eliminated via feces through biliary secretion of polar metabolites.^[14] In the liver, surplus retinol is oxidized by cytochrome P450 enzymes (e.g., CYP26 family) to water-soluble retinoic acid derivatives, which are conjugated with glucuronic acid and excreted in bile, or further metabolized for renal elimination.^[12] The efficiency of retinyl acetate metabolism is influenced by nutritional status, particularly dietary fat, zinc, and protein availability. Adequate dietary fat (at least 3-5 g per meal) is essential for micellar solubilization and optimal absorption, while deficiencies reduce uptake significantly.^[13] Zinc and protein support RBP synthesis and overall transport, with their deficiencies impairing mobilization from hepatic stores and leading to functional vitamin A shortages despite adequate intake.^[15]

Biochemical Functions

Retinyl acetate, an esterified form of vitamin A, undergoes hydrolysis in the intestinal mucosa and liver by retinyl ester hydrolases to yield retinol, the primary alcohol form of the vitamin.^[12] This retinol is then sequentially oxidized: first to retinaldehyde (retinal) by alcohol dehydrogenases (such as ADH1, ADH3, and ADH4) or specific retinol dehydrogenases, and subsequently to retinoic acid by retinal dehydrogenases (RALDH enzymes, including RALDH1, RALDH2, and RALDH3).^[16] These conversions are essential for activating retinyl acetate's metabolites, with retinoic acid serving as the primary bioactive form that exerts genomic effects. In terms of vitamin A activity, 1 mg of retinyl acetate corresponds to approximately 0.872 mg of retinol activity equivalents (RAE), accounting for the molecular weight difference between the ester and free retinol.^[17] Retinoic acid functions as a ligand for nuclear receptors, specifically retinoic acid receptors (RARs) and retinoid X receptors (RXRs), forming heterodimers that bind to retinoic acid response elements in DNA to regulate gene transcription.^[18] This signaling pathway governs critical cellular processes, including cell differentiation, proliferation, and apoptosis, particularly in epithelial tissues where it maintains integrity and barrier function.^[19] In vision, retinal (derived from retinol) is isomerized to 11-cis-retinal, which binds to opsin in rod cells to form rhodopsin, the light-sensitive pigment essential for phototransduction and low-light detection.^[20] Retinoic acid also modulates immune responses by promoting differentiation of immune cells and regulating cytokine production, while supporting reproduction through roles in gametogenesis and fetal implantation.^[21] In embryonic development, retinoic acid gradients orchestrated by RALDH enzymes pattern the anterior-posterior axis, influencing organogenesis in structures like the heart, limbs, and central nervous system; however, excessive levels can lead to teratogenic effects such as craniofacial and cardiac malformations.^[22] Additionally, retinol derived from retinyl acetate exhibits antioxidant properties by scavenging free radicals and inhibiting lipid peroxidation, complementing its role in cellular protection.^[23] Impairments in these metabolic pathways due to vitamin A deficiency manifest as night blindness from reduced rhodopsin regeneration and xerophthalmia, characterized by corneal drying and ulceration from disrupted epithelial maintenance.^[24]

Production and Stability

Industrial Synthesis

Retinyl acetate is primarily produced industrially through the esterification of retinol with acetic anhydride or acetyl chloride, typically in the presence of a base catalyst such as pyridine. This reaction converts the alcohol group of retinol to the acetate ester, enhancing stability for commercial applications, and achieves yields exceeding 90%. The process is conducted under controlled conditions to minimize isomerization and ensure high purity, often followed by purification via high-performance liquid chromatography (HPLC) or crystallization to attain greater than 95% purity suitable for pharmaceutical grades. Scale-up involves batch or continuous reactors, with considerations for handling light-sensitive intermediates to prevent degradation.^[25]^[26] Synthetic routes to retinyl acetate dominate modern production, beginning with total synthesis from β-ionone as the key starting material. The polyene chain is constructed via coupling reactions, such as the Wittig reaction in BASF's C15 + C5 process or the Julia olefination in Rhône-Poulenc's variant, followed by reduction to retinol and subsequent acetylation. Historical development traces to the 1940s, with the first industrial synthesis achieved by Isler et al. at Hoffmann-La Roche in 1947 using a C14 + C6 Grignard-based route, enabling commercial production by 1948 at scales initially yielding 168 kg annually and expanding to thousands of tons by the 1970s. These methods, refined by companies like DSM and BASF, now produce multi-ton quantities annually, prioritizing the all-trans isomer for bioactivity.^[25]^[26] Natural sourcing of vitamin A, though less prevalent today due to the cost and scalability advantages of synthesis, involves extraction of retinyl esters (primarily palmitate) from animal livers or cod liver oil. These can be hydrolyzed to retinol and then esterified to retinyl acetate if needed, but retinyl acetate itself is predominantly synthetic and not commonly used in "natural" labeled products, which typically retain longer-chain esters like palmitate. This extraction approach was historically significant before widespread synthetic adoption in the mid-20th century.^[25]^[24] Emerging biotechnological methods offer sustainable alternatives to traditional chemical synthesis. As of 2024, processes using engineered oleaginous yeasts, such as Yarrowia lipolytica, enable microbial production of retinyl acetate through metabolic engineering, potentially reducing environmental impact and reliance on petrochemical feedstocks.^[27] Industrial processes manage byproducts and waste through recovery techniques, such as acetic acid distillation from esterification and recycling of triphenylphosphine oxide from Wittig reactions. Volatile solvents like hexane or toluene are captured via distillation columns, with environmental controls including catalytic optimizations to reduce emissions and hazardous waste. These measures align with green chemistry principles, minimizing the ecological footprint of large-scale production.^[25]^[26]

Stability Factors

Retinyl acetate is susceptible to several degradation mechanisms that compromise its potency, primarily due to its polyene structure. Photo-oxidation occurs under ultraviolet irradiation, where the molecule undergoes ionic photodissociation, leading to isomerization into cis forms and formation of byproducts such as anhydroretinol, with reactive oxygen species contributing to oxidation of the conjugated double bonds. Thermal isomerization can also shift the all-trans configuration to less active cis isomers, particularly at elevated temperatures, while hydrolysis degrades the ester linkage in moist or aqueous environments, accelerating in alkaline conditions where the acetate group is cleaved.^[28]^[29] Compared to free retinol, retinyl acetate exhibits enhanced stability owing to the protective acetate ester group, which shields the reactive hydroxyl functionality from rapid oxidation and isomerization. This results in a significantly longer half-life in the presence of air and light—typically on the order of months for retinyl acetate versus mere days for retinol under similar exposure. The ester form reduces sensitivity to environmental stressors, making it preferable for formulations requiring prolonged shelf presence.^[30]^[29] Optimal storage conditions are essential to minimize degradation, with recommendations including packaging in amber glass to block light penetration, maintenance under an inert atmosphere such as nitrogen or argon to prevent oxidation, and temperatures below 25°C to limit thermal effects. Incorporation of antioxidants like butylated hydroxytoluene (BHT) or tocopherols further stabilizes the compound by scavenging free radicals and inhibiting auto-oxidation during storage. In formulations for foods and supplements, microencapsulation using materials such as gelatin or starch matrices provides a physical barrier against oxygen, light, and moisture, thereby enhancing retention of bioactivity during processing and distribution. Retinyl acetate demonstrates optimal stability within a pH range of 4 to 7, where acidic to neutral environments minimize hydrolytic breakdown, though deviations can accelerate ester cleavage. Under these controlled conditions, shelf life typically extends to 2-3 years, monitored through potency assays that quantify retention of the active all-trans isomer.^[31]^[32]

Applications

Food Fortification

Retinyl acetate serves as a key fortificant for enhancing the vitamin A content in staple foods, particularly in margarine, milk, cereals, and infant formulas, where it is added at levels typically ranging from 500 to 3000 IU per serving to meet a significant portion of daily requirements.^[24]^[33] This form is preferred for its compatibility with lipid-rich matrices, ensuring even distribution during manufacturing.^[34] The rationale for using retinyl acetate in food fortification lies in its chemical stability as an oil-soluble retinol ester, which resists degradation in oil-based vehicles and delivers bioavailable preformed vitamin A to populations at risk of deficiency, especially in developing regions where dietary intake from natural sources is often inadequate.^[34] Its high bioavailability, comparable to other retinol forms, supports efficient absorption in the intestine following hydrolysis to retinol.^[13] Incorporation of retinyl acetate involves emulsification for aqueous products like milk and infant formulas to create stable dispersions, or dry blending for powdered cereals and milk to achieve uniform mixing without altering texture.^[34] During thermal processing, such as extrusion for cereals or baking for fortified products, retention rates often exceed 80%, with losses minimized through antioxidant protection and controlled conditions.^[35]^[36] Integration of retinyl acetate fortification aligns with WHO and UNICEF global initiatives to combat micronutrient deficiencies, including standards for mandatory addition to edible oils, dairy, and staples in countries like India and several African nations since the early 2000s.^[37] These programs target high-burden areas, promoting widespread access through national policies and partnerships.^[38] Efficacy evaluations of retinyl acetate-fortified foods indicate substantial public health impacts, with studies reporting significant improvements in serum retinol levels (standardized mean difference of 0.31) and protection of approximately 2.7 million children from vitamin A deficiency, along with decreased clinical symptoms.^[39]^[40]

Dietary Supplements

Retinyl acetate is a common form of preformed vitamin A found in dietary supplements, available in softgel capsules, tablets, and liquid formulations with typical dosages ranging from 5,000 to 25,000 international units (IU) per serving.^[24] These supplements are frequently incorporated into multivitamin products, where they may be combined with other nutrients like vitamin E to support antioxidant activity or vitamin D for overall bone and immune health.^[41] The primary target uses of retinyl acetate supplements include preventing vitamin A deficiency, which can lead to impaired vision and increased infection risk, as well as supporting eye health by aiding retinal function for night vision and color perception.^[42] Additionally, it bolsters immune function by maintaining epithelial integrity and promoting T-cell activity, making it a standard component in multivitamins for general wellness.^[43] Bioavailability of retinyl acetate is high, with absorption rates of 70-90% when consumed alongside dietary fats, which facilitate its uptake in the intestines as a fat-soluble compound.^[24] This direct provision of retinol makes it preferable to beta-carotene supplements, which exhibit only 10-30% absorption and require enzymatic conversion, potentially limiting efficacy in individuals with conversion impairments.^[24] The global market for vitamin A, including dietary supplements featuring retinyl acetate, exceeded USD 540 million in 2022 and continues to grow, driven by demand for nutritional support in developed and developing regions.^[44] Synthetic retinyl acetate provides a vegan-friendly alternative to animal-derived forms, appealing to plant-based consumers seeking preformed vitamin A without relying solely on provitamin carotenoids.^[45] Clinical trials have shown retinyl acetate supplementation's efficacy in reducing measles-related mortality and complications in children under two years, with megadoses lowering overall death rates by up to 30% in deficient populations.^[46] In anemic children, supplementation has improved hemoglobin levels by approximately 7 g/L and decreased anemia prevalence from 54% to 38%, particularly when combined with iron therapy in those with concurrent deficiencies.^[47]

Cosmetics

Retinyl acetate serves as a stable ester derivative of retinol in cosmetic formulations, providing mild retinoid activity that stimulates collagen production and epidermal cell turnover to address signs of photoaging, such as fine lines, wrinkles, and uneven texture. Unlike retinoic acid, which can cause significant irritation, retinyl acetate exhibits lower potential for redness and dryness, positioning it as a gentler option for over-the-counter anti-aging products. This pro-vitamin A compound is enzymatically converted to active retinol in the skin, supporting gradual improvements in skin firmness and smoothness without the intensity of prescription-strength retinoids.^[48]^[49] In skincare applications, retinyl acetate is commonly formulated into creams, serums, and sunscreens at concentrations of 0.1% to 1%, often expressed in retinol equivalents to ensure safety and efficacy; regulatory guidelines limit it to 0.3% retinol equivalents in leave-on facial products like moisturizers and 0.05% in body lotions to minimize systemic absorption risks. These levels allow for effective dermal delivery while combined with emollients and antioxidants to counteract potential dryness. Clinical evidence from combination studies demonstrates its role in enhancing skin plumping and smoothing, with formulations containing retinyl acetate alongside polyhydroxy acids showing statistically significant anti-aging effects on photoaged skin after regular use.^[50]^[51] Formulation challenges for retinyl acetate include its sensitivity to light, oxygen, and heat, necessitating opaque, airless packaging to preserve potency and prevent degradation during storage and application. As an ester, it offers inherent slow-release properties for sustained retinoid activity, reducing peak irritation compared to free retinol, though stabilizers like vitamin E are frequently added to enhance longevity in emulsions. This stability advantage has facilitated its inclusion in diverse products since the 1990s, contributing to the growth of the vitamin A cosmetics segment, valued at approximately $900 million globally in 2023 and projected to exceed $1 billion by 2024 in key markets like the EU and USA.^[52] Representative products featuring retinyl acetate include A313 Vitamin A Pommade for targeted repair, Infadolan Cream for moisturizing with anti-aging support, and Cosmedix Timeless Peel for exfoliating treatments, often from brands emphasizing accessible retinoid innovation. Studies on similar retinoid esters report 20-30% improvements in photoaged skin parameters, such as wrinkle depth and elasticity, after 12 weeks of twice-daily application, underscoring its practical value in cosmetic routines despite limited standalone trials.^[53]^[54]

Safety and Regulation

Toxicity and Health Effects

Retinyl acetate, as a form of preformed vitamin A, exhibits low acute toxicity, with an oral LD50 greater than 2,000 mg/kg body weight in rats, indicating it is not highly hazardous in single high-dose exposures.^[55] High single doses may cause symptoms such as nausea, vomiting, vertigo, and blurred vision due to rapid onset of hypervitaminosis A-like effects.^[56] Chronic overexposure to retinyl acetate, typically exceeding 3,000 mcg retinol activity equivalents (RAE) per day (equivalent to about 10,000 IU), can lead to hypervitaminosis A, resulting in liver damage such as hepatotoxicity, fibrosis, and splenomegaly, as well as bone loss through increased resorption and reduced formation, potentially contributing to osteoporosis.^[57] Teratogenic risks are particularly notable, with intakes above 10,000 IU per day during pregnancy associated with congenital malformations including craniofacial, cardiac, and central nervous system defects in the fetus.^[58] Vulnerable populations include pregnant women, who should limit intake to no more than 3,000 mcg RAE daily to avoid these risks; children, who may experience amplified effects due to lower body mass and developing systems; and individuals with pre-existing liver disease, where impaired metabolism heightens susceptibility to accumulation and toxicity.^[59] Interactions with other substances can exacerbate retinyl acetate toxicity; concurrent use with alcohol may intensify liver strain and damage, while combination with isotretinoin, a synthetic retinoid, heightens the risk of hypervitaminosis A, manifesting in symptoms such as dry, scaly skin, hair loss, and brittle nails.^[60] A 2021 review has cited evidence from prior studies linking high supplemental intakes of preformed vitamin A, such as retinyl acetate, to an elevated risk of hip fractures in adults, particularly postmenopausal women, due to adverse effects on bone density.^[61]

Regulatory Standards

Retinyl acetate, as a form of preformed vitamin A, is subject to international guidelines established by bodies such as the Codex Alimentarius Commission and the World Health Organization (WHO). The Codex provides specific maximum levels for vitamin A fortification in targeted products, including up to 1.2 mg per 100 g in ready-to-use therapeutic foods to prevent deficiency while avoiding excess intake.^[62] The WHO sets the tolerable upper intake level (UL) for preformed vitamin A at 3000 mcg retinol activity equivalents (RAE) per day for adults, applicable to total intake from all sources including supplements and fortified foods.^[24] In the United States, the Food and Drug Administration (FDA) affirms retinyl acetate as generally recognized as safe (GRAS) for use as a nutrient supplement in foods, with limitations based on current good manufacturing practices.^[63] It is commonly labeled as "vitamin A acetate" in dietary supplements, where content must be declared in mcg RAE on the Supplement Facts panel. High-dose formulations carry pregnancy warnings due to teratogenic risks when exceeding recommended levels during pregnancy.^[64] European Union regulations, guided by the European Food Safety Authority (EFSA), maintain a UL of 3000 mcg retinol equivalents (RE) per day for preformed vitamin A from supplements for adults.^[65] In cosmetics, the Scientific Committee on Consumer Safety (SCCS) deems retinyl acetate safe at concentrations up to 0.3% RE in leave-on products excluding body lotions (limited to 0.05% RE), following revisions to ensure systemic exposure remains below the UL.^[50] Labeling requirements across jurisdictions mandate expression of vitamin A content in RAE or RE to reflect bioavailability accurately, as updated in FDA rules effective 2020-2021 and aligned EU standards. Warnings for high-dose products, introduced or strengthened in the 2010s, advise against exceeding the UL; the EU's 2024 Regulation (EU) 2024/996 further requires cosmetic labels to warn that additional vitamin A from food or supplements may surpass safe limits.^[66]^[67] Compliance and monitoring involve post-market surveillance by agencies like the FDA to identify adulteration, such as undeclared excesses or contaminants in vitamin A-fortified products and supplements.^[68]

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If you have concerns about vitamin A, taking a vegan supplement providing a small amount of preformed vitamin A in the form of retinol is another option.
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The authors conclude that vitamin A megadoses appear effective in reducing mortality from measles in children under two years old and have few associated ...
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Vitamin A treatment increased mean hemoglobin by 7 g/L (P < 0.02) and reduced the prevalence of anemia from 54% to 38% (P < 0.01). Vitamin A treatment increased ...
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The results showed that the delivery of retinyl acetate to the dermis could be achieved by a suitable polymeric carrier.
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Oct 26, 2022 · The SCCS is of the opinion that vitamin A in cosmetics at the concentrations of 0.05% Retinol Equivalent (RE) in body lotion, and 0.3% RE for other leave-on ...Missing: skincare | Show results with:skincare
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PHAs plus retinyl acetate (pro-vitamin A) in a cream base exhibited significant antiaging skin benefits such as skin smoothing and plumping. PHAs plus ...
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Vitamin A Beauty Products Market Size, Share, Growth & Forecast
Rating 4.5 (40) Vitamin A Beauty Products Market size was valued at USD 898.4 Million in 2023 and is projected to reach USD 61.98 Billion by 2031, growing at a CAGR of 5.9%.
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Objective To evaluate the effectiveness of topical retinol (vitamin A) in improving the clinical signs of naturally aged skin.
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Nov 4, 2020 · Higher doses of vitamin A can be toxic, leading to a constellation of signs and symptoms as well as liver injury, jaundice, enlargement of the liver and spleen.
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Although doses of 10,000 IU/d or less of preformed vitamin A (retinyl esters and retinol) are considered safe, doses > 10,000 IU/d as supplements have been ...
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During pregnancy, a daily supplement should not exceed 10 000 IU (3000 RE) and a weekly supplement should not exceed 25 000 IU (7500 RE).
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Proposal for Codex Guideline for RUTF: Vitamin A minimum, maximum and upper limits ... maximum level of vitamin A is 1.2mg and a guided upper limit of 1.6mg. Min.Missing: retinyl acetate
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21 CFR 184.1930 -- Vitamin A. - eCFR
Vitamin A (retinol) is an alcohol, extracted from fish liver oils or synthesized. It's used as a nutrient supplement in food, with no limitations other than ...<|separator|>
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Sep 8, 2025 · Advice and warnings for the use of Vitamin a during pregnancy. FDA Pregnancy Category X - Not for use in pregnancy.
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Mar 5, 2024 · Similarly, the Supplement Facts label is required to list the same ... Vitamin A, 900mcg RAE. Vitamin B6, 1.7mg. Vitamin B12, 2.4mcg. Vitamin ...
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Apr 3, 2024 · In addition, a warning should be included to inform consumers already exposed to vitamin A from food and food supplements of the possibility of ...
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Jun 24, 2025 · On April 3, 2024, the European Commission published Regulation (EU) 2024/996, introducing new restrictions on Vitamin A and its derivatives ...