Fact-checked by Grok 2 weeks ago

Rib cage

The rib cage, also known as the thoracic cage, is a semi-rigid bony structure that encloses and protects the thoracic cavity, consisting of twelve pairs of curved ribs, the sternum (breastbone), and the twelve thoracic vertebrae.^[1]^[2] It forms the central framework of the chest wall, safeguarding vital organs such as the heart, lungs, and major blood vessels while enabling respiratory movements through its flexible articulations.^[1]^[2] Structurally, the rib cage is anchored posteriorly to the thoracic vertebrae via costovertebral joints, where each rib's head articulates with the bodies of one or two adjacent vertebrae, and the tubercle connects to the transverse processes.^[1] Anteriorly, the ribs connect to the sternum either directly or indirectly through costal cartilages, which provide elasticity.^[2] The sternum itself is divided into three parts: the superior manubrium, which includes the jugular notch; the central body; and the inferior xiphoid process, which is cartilaginous in youth and ossifies with age.^[2] Each rib features a head, neck, tubercle, shaft (body), and costal groove that houses neurovascular structures, with the first rib being short and flat, and the lower ribs becoming shorter and more curved.^[1] Ribs are classified into three types based on their anterior attachments: true ribs (pairs 1–7), which attach directly to the sternum via individual costal cartilages; false ribs (pairs 8–10), which connect indirectly to the sternum through the shared cartilage of the seventh rib; and floating ribs (pairs 11–12), which lack any anterior sternal connection and instead end in the abdominal musculature.^[1]^[2] This classification reflects variations in length, curvature, and articulation facets, with atypical features in ribs 1, 2, 10, 11, and 12, such as single articular facets or absent necks.^[1] In terms of function, the rib cage provides mechanical protection against trauma to the thoracic contents and serves as an attachment site for respiratory muscles like the intercostals and diaphragm, as well as postural muscles.^[1] During inhalation, the ribs elevate via a "bucket-handle" or "pump-handle" motion, increasing thoracic volume to draw air into the lungs, while exhalation involves passive recoil or active contraction.^[2] Additionally, the rib cage contributes to erythropoiesis (red blood cell production) during fetal development and maintains the cylindrical shape of the chest wall for efficient ventilation.^[1]

Anatomy

Bones and components

The rib cage, also known as the thoracic cage, is composed of 12 pairs of ribs, the sternum, and the 12 thoracic vertebrae (T1-T12), forming a bony enclosure that encases the thoracic cavity.^[3] The ribs articulate posteriorly with the thoracic vertebrae and anteriorly with the sternum via costal cartilages, while the thoracic vertebrae provide the posterior foundation through their specialized articulations.^[1] The ribs are classified based on their anterior attachments to the sternum: the first seven pairs (ribs 1-7) are true ribs, which connect directly to the sternum through individual costal cartilages; ribs 8-10 are false ribs, attaching indirectly to the sternum via the shared costal cartilage of the seventh rib; and ribs 11-12 are floating ribs, which lack any anterior sternal connection and end freely in the abdominal musculature.^[1] Additionally, ribs are categorized as typical or atypical; typical ribs (3-9) feature a consistent structure with a head bearing two articular facets, a neck, a tubercle, a shaft, and a costal groove, whereas atypical ribs include the first (short, flat, with a single facet and two grooves), second (longer and thinner, with a rough tuberosity), tenth (single facet on the head), and eleventh and twelfth (short, with a single facet and no neck or tubercle).^[4] The sternum, a flat, elongated bone located in the midline of the anterior thoracic wall, consists of three main segments: the superior manubrium, the central body (or mesosternum), and the inferior xiphoid process.^[5] The manubrium features the prominent jugular notch at its superior border, flanked by clavicular notches for articulation with the clavicles, and it bears costal notches for the first and second ribs; the body contains costal notches for ribs 2-7, forming the sternal angle (angle of Louis) at its junction with the manubrium; the xiphoid process varies in shape and may ossify variably in adulthood.^[5] Posteriorly, the ribs connect to the thoracic vertebrae via costovertebral joints, where the head of each rib (except the first and second, which articulate with one or two vertebrae respectively) articulates with the demi-facets on adjacent vertebral bodies, and costotransverse joints, where the rib tubercle attaches to the transverse process of the corresponding vertebra.^[1] Anteriorly, the true ribs form sternocostal joints with the sternum, which are synovial for ribs 2-7 and synchondroses for the first rib, allowing limited movement essential to thoracic dynamics.^[4] The thoracic vertebrae (T1-T12) are characterized by their heart-shaped bodies, circular vertebral foramina, and costal facets on the bodies and transverse processes to accommodate these rib articulations.^[3]

Rib structure and attachments

A typical rib consists of several distinct anatomical components that facilitate its role in the thoracic framework. The head, located at the posterior end, is wedge-shaped and features two articular facets: a superior facet that articulates with the body of the vertebra of the same number, and an inferior facet that connects to the body of the vertebra immediately below.^[1] Adjacent to the head is the neck, a short, constricted region approximately 2-3 cm long that lacks muscular attachments and serves primarily as a transitional segment.^[6] The tubercle, situated at the junction of the neck and shaft, comprises an articular portion medially that forms a synovial joint with the transverse process of the vertebra, and a non-articular portion laterally that provides attachment for the lateral costotransverse ligament.^[7] The shaft, or body, forms the bulk of the rib and is characterized by a thin, flat structure with a prominent angle about 5 cm from the tubercle, where it bends sharply; this angle marks the site of attachment for the iliocostalis muscle.^[1] Running along the inferior internal border of the shaft is the costal groove, which houses the intercostal neurovascular bundle (vein, artery, nerve) for protection.^[6] At the anterior end, the shaft transitions into the flexible costal cartilage, a strip of hyaline cartilage that extends the rib's length and enables slight movement during respiration.^[7] Posteriorly, ribs articulate with the thoracic vertebrae through two main joints: the costovertebral joint, where the head of the rib connects to the vertebral bodies, and the costotransverse joint, where the tubercle attaches to the transverse process.^[1] These are diarthrodial (synovial) joints that permit gliding motions essential for thoracic expansion.^[8] The costovertebral joint is reinforced by the radiate ligament of the head of the rib, which fans out from the anterior surface of the rib head to the vertebral bodies and intervertebral disc, providing stability while allowing limited rotation.^[9] An intra-articular ligament within this joint extends from the rib head to the intervertebral disc, dividing the joint cavity and further limiting excessive movement.^[8] The costotransverse joint is supported by three ligaments: the superior costotransverse ligament (connecting the rib neck to the vertebra above), the lateral costotransverse ligament (from the tubercle to the transverse process), and the posterior costotransverse ligament (spanning adjacent transverse processes).^[9] These ligaments collectively restrict lateral and vertical displacement, ensuring coordinated rib motion.^[1] Anteriorly, the costal cartilages of the first seven ribs (true ribs) attach directly to the sternum via sternocostal joints.^[1] The first sternocostal joint is a synchondrosis, where the cartilage fuses immovably with the manubrium using hyaline cartilage, providing rigid support at the superior thorax.^[10] In contrast, the second through seventh sternocostal joints are synovial plane joints (arthrodial), allowing slight gliding between the cartilage and sternal costal notches, which contributes to respiratory flexibility.^[10] For ribs 8-10 (false ribs), the costal cartilages connect indirectly to the seventh cartilage via syndesmoses—inferior attachments formed by fibrous tissue—rather than directly to the sternum.^[1] Ribs 11 and 12 lack anterior attachments entirely, ending free in the abdominal musculature.^[6] Ribs exhibit a characteristic curvature that enhances their protective and mechanical functions: the posterior aspect is convex to conform to the vertebral column, while the anterior aspect is concave, forming a broad thoracic arch.^[7] This S-shaped asymmetry allows the ribs to project laterally and anteriorly, creating space for thoracic organs.^[6] In terms of length, ribs progressively increase from the shortest first pair (about 12 cm) to the longest seventh pair (about 25 cm), then gradually decrease toward the twelfth pair, optimizing the conical shape of the rib cage for volume expansion during breathing.^[1]

Development and ossification

The rib cage originates from the paraxial mesoderm, particularly the sclerotome component of somites, which begin forming during the third week of embryonic development and differentiate around weeks 4 to 5.^[11] These sclerotomal cells migrate ventrally to contribute to the axial skeleton, including the ribs, under the influence of Hox genes that establish segmental identity and patterning along the anterior-posterior axis.^[12] Hox gene expression boundaries align with somite formation, ensuring proper rib positioning relative to vertebrae, as disruptions in Hox5, Hox6, and Hox9 lead to reduced rib cage size in model organisms.^[13] Rib primordia emerge as mesenchymal condensations around week 7 of gestation, with cartilage models forming by week 8 as the thoracic region expands.^[14] Primary ossification centers appear in the rib shafts starting at approximately day 55 (late week 8), initially in the mid-thoracic ribs (6th and 7th pairs), progressing outward to form a structured thorax by day 57, with all but the first and twelfth ribs ossified.^[15] Secondary ossification centers develop postnatally in the rib heads and tubercles, typically around puberty, allowing for further maturation.^[16] Rib growth proceeds via endochondral ossification, in which the initial hyaline cartilage template is progressively replaced by bone from the primary centers, while peripheral cartilage persists for flexibility and elongation.^[17] Longitudinal expansion occurs primarily through interstitial growth in the costal cartilage, which connects ribs to the sternum and permits thoracic adaptation during respiration and growth. The sternum, integral to rib cage stability, forms from multiple ossification centers in its segments (manubrium, body sternebrae, and xiphoid), with fusion of the body segments completing by ages 20 to 25.^[18] Developmental influences include genetic factors, such as mutations in the PAX1 gene, which disrupt sclerotomal differentiation and result in malformed or absent proximal ribs, as observed in mouse models.^[19] Environmental factors, like maternal smoking during pregnancy, elevate the risk of musculoskeletal defects, potentially affecting rib formation through vascular and cellular disruptions in the embryonic thorax.^[20]

Anatomical variations

The human rib cage exhibits several normal anatomical variations that deviate from the typical configuration of 12 pairs of ribs. These include variations in rib count, where individuals may have 11 or 13 pairs of ribs, occurring in approximately 1-5% of the population, often detected incidentally on imaging.^[21] Asymmetry in rib length or curvature is also common, with hypoplastic or short ribs—a condition where a rib fails to reach the sternum—reported in about 16% of cases, more frequently on the right side and sometimes bilaterally.^[22] Additionally, sternal foramen, a congenital defect forming a rounded opening in the sternal body, is present in 4-8% of individuals, typically in the lower sternum and without clinical significance in most cases.^[23] Congenital anomalies of the ribs represent more pronounced structural deviations arising during embryonic development. Cervical ribs, supernumerary ribs articulating with the seventh cervical vertebra, occur in 0.5-1% of the population and are more prevalent in females, potentially linked to genetic factors influencing somite segmentation.^[24] Lumbar ribs, extra ribs at the first lumbar vertebra, are rarer and often asymptomatic. Bifid ribs, characterized by a forked anterior end usually affecting the fourth rib, and fused ribs, involving partial or complete union of adjacent ribs due to failed segmentation, are infrequent anomalies sometimes associated with syndromes like Gorlin syndrome.^[22] Sex-based differences in rib cage anatomy include a generally smaller overall volume in females compared to males of equivalent height, approximately 10% less, though female rib cages may exhibit relatively broader dimensions to accommodate pregnancy-related physiological demands.^[25] Ethnic variations are subtler but notable; for instance, individuals of tropical or African descent tend to have smaller, more slender rib cages compared to those from higher latitudes or European populations, with potential differences in floating rib incidence influenced by genetic and environmental factors during development. These variations are typically identified through radiographic imaging, such as computed tomography, and cervical ribs in particular show higher detection rates in females.^[26]

Function

Respiratory mechanics

The rib cage plays a central role in respiration by facilitating changes in thoracic volume through coordinated movements of the ribs, sternum, and associated cartilages. During inhalation, the ribs elevate and rotate outward, expanding the thoracic cavity in multiple dimensions to draw air into the lungs. This dynamic motion is enabled by the articulations at the costovertebral and costochondral joints, allowing the rib cage to act as a bellows-like structure.^[27] Inhalation involves two primary types of rib motion: the pump-handle movement, predominant in upper ribs (1-7), which elevates the anterior ribs and sternum, enhancing the anteroposterior diameter; and the bucket-handle movement, seen mainly in lower ribs (8-10), which produces lateral expansion by rotating the ribs around a transverse axis, increasing the transverse diameter of the thorax. These actions are driven primarily by the contraction of the external intercostal muscles, which span between adjacent ribs and pull them superiorly and laterally. The diaphragm contributes by contracting and descending, with its costal fibers originating from the inner surfaces of the lower ribs (primarily ribs 7-12) and inserting onto the central tendon, further aiding rib elevation and stabilizing the lower thorax. Accessory muscles such as the scalene muscles (attaching to ribs 1-2) and pectoralis minor (to ribs 3-5) assist in elevating the upper ribs during deeper breaths.^[27]^[28] Exhalation, in contrast, is largely passive during quiet breathing, relying on the elastic recoil of the lungs and the thoracic wall, including the inherent elasticity of the costal cartilages that connect the ribs to the sternum. This recoil depresses the ribs and sternum, reducing thoracic volume and expelling air. During forced exhalation, the internal intercostal muscles contract to actively depress the ribs, enhancing the downward and inward motion.^[27]^[27] These respiratory movements result in significant increases in intrathoracic volume; rib elevation contributes approximately 25-30% to the inspiratory expansion of thoracic volume, supporting vital capacity by augmenting the transverse and anteroposterior diameters. Biomechanically, the costovertebral joints permit rotations of about 10-15 degrees for the pump-handle and bucket-handle components, with the elasticity of the costal cartilages allowing deformation up to several millimeters while returning to resting position. This joint mobility and cartilage compliance ensure efficient, reversible changes in thoracic dimensions without excessive energy expenditure.^[29]^[30]^[27]

Protective and structural roles

The rib cage functions as a robust protective barrier for the vital organs within the thoracic cavity, primarily enclosing the heart, lungs, and great vessels such as the aorta. This enclosure is formed by the sternum anteriorly, the 12 pairs of ribs laterally, and the thoracic vertebrae posteriorly, creating a semi-rigid bony framework that shields these structures from external impacts and trauma. The costal cartilages, which connect the ribs to the sternum, introduce flexibility to the system, allowing the cage to deform slightly under force and distribute mechanical stress across multiple points rather than concentrating it on individual bones, thereby enhancing overall resilience without compromising enclosure integrity.^[31]^[32]^[33] Structurally, the rib cage anchors numerous thoracic and upper limb muscles, contributing to postural stability and the maintenance of thoracic kyphosis—the characteristic forward curvature of the upper spine. Key attachments include the serratus anterior muscle, which originates from the outer surfaces of the upper eight or nine ribs to stabilize the scapula, and portions of the pectoralis major, which originate from the sternum and costal cartilages of the upper ribs to support arm adduction and flexion. In collaboration with the thoracic vertebrae and intervertebral discs, the rib cage reinforces spinal alignment, preventing excessive collapse or deviation under gravitational loads and promoting upright posture. This muscular scaffolding also integrates with ligaments to bolster the thoracic region's overall rigidity.^[33]^[34]^[35] The rib cage facilitates load distribution by serving as an intermediary between the upper limbs and the axial skeleton, transferring forces generated during arm movements or weight-bearing to the spine and pelvis. Muscles like the serratus anterior and latissimus dorsi, anchored to the ribs, enable this transmission while stabilizing the shoulder girdle against shear and rotational stresses, particularly during locomotion or dynamic activities. This biomechanical role enhances whole-body equilibrium by dissipating upper extremity loads across the broader thoracic framework, reducing localized strain on the vertebrae.^[34]^[36]^[35] Supporting these protective and structural functions, the rib cage receives its blood supply and innervation via intercostal neurovascular bundles that traverse the costal grooves—inferior sulci on each rib's inner surface, sheltered by the overhanging inferior border. Posterior intercostal arteries branch from the thoracic aorta to supply the posterior thoracic wall, while anterior intercostal arteries derive from the internal thoracic artery for the upper six spaces and the musculophrenic artery for the lower ones; accompanying veins drain into the azygos or internal thoracic systems. The intercostal nerves, originating from thoracic spinal segments T1–T11, run parallel to these vessels, providing motor innervation to intercostal muscles for stability and sensory input to the thoracic skin and pleura. This organized bundle ensures continuous nourishment and neural control, vital for maintaining the cage's mechanical integrity.^[37]^[38]^[39]

Clinical significance

Injuries and trauma

The rib cage is susceptible to various injuries due to its role in protecting vital organs and facilitating movement during respiration. Fractures represent the most common form of rib cage trauma, classified into several types based on the nature and extent of bone disruption. Simple or closed fractures involve a single break in the rib without penetration of the skin or surrounding tissues, often healing with conservative management.^[40] Comminuted fractures occur when the rib shatters into multiple fragments, increasing the risk of displacement and associated soft tissue damage.^[40] Stress fractures, resulting from repetitive microtrauma rather than acute force, are less common in the general population but seen in athletes or individuals with chronic overuse.^[40] The middle ribs (typically 5 through 9) are the most frequently affected sites due to their greater mobility and thinner cortical bone compared to the upper or lower ribs.^[40] Trauma to the rib cage arises from diverse mechanisms, broadly categorized as blunt, penetrating, or high-impact forces. Blunt trauma, such as falls from standing height or assaults with fists or blunt objects, accounts for a significant portion of cases and often results in isolated fractures without deep organ involvement.^[41] Penetrating injuries, including stab wounds or gunshot injuries, directly breach the chest wall and rib integrity, potentially leading to immediate vascular or pulmonary damage.^[40] High-impact events like motor vehicle collisions can cause multiple fractures across several ribs, sometimes resulting in flail chest—a severe condition where a segment of the chest wall becomes detached and moves paradoxically during breathing due to three or more consecutive ribs fractured in two places.^[40] Motor vehicle accidents are the leading mechanism overall, comprising over 50% of rib fracture cases in trauma registries.^[42] Immediate effects of rib cage injuries extend beyond skeletal disruption to critical complications that threaten respiratory and hemodynamic stability. Displaced fracture fragments may puncture the lungs, causing pneumothorax (air in the pleural space) or hemothorax (blood accumulation), both of which impair ventilation and oxygenation. In severe cases, sharp bone edges can lacerate adjacent organs such as the spleen or liver, leading to internal hemorrhage and hypovolemic shock.^[40] Flail chest exacerbates these risks by destabilizing the chest wall, promoting atelectasis and hypoxia, with associated mortality rates ranging from 10% to 20%.^[43] Rib cage injuries occur in approximately 10% to 15% of all major trauma presentations, with higher prevalence in blunt chest trauma where 10-40% of patients sustain fractures.^[44]^[45] Incidence rises significantly in the elderly population, where osteoporosis weakens bone density and increases fracture susceptibility; falls from low heights are a primary mechanism in this group, affecting over 50% of older adults with rib fractures.^[41] Each additional rib fracture in elderly patients elevates mortality odds by about 19% and pneumonia risk by 27%, underscoring the amplified immediate impact in this demographic. Recent studies as of 2024 indicate increasing adoption of surgical stabilization for multiple rib fractures to improve outcomes in high-risk groups.^[41]^[45]

Associated diseases and conditions

The rib cage is susceptible to several non-traumatic diseases that compromise its structural integrity and function, ranging from degenerative bone loss to infectious, neoplastic, and congenital anomalies. These conditions often manifest through alterations in bone density, cartilage inflammation, tumor growth, or developmental malformations, leading to impaired respiratory mechanics or protective roles without acute injury. Osteoporosis, a systemic skeletal disorder marked by diminished bone mineral density and microarchitectural deterioration, heightens the risk of rib fractures in affected individuals. This fragility arises from imbalanced bone remodeling, where resorption exceeds formation, particularly exacerbated by estrogen deficiency in postmenopausal women, who face a lifetime fracture risk of up to 50%. Rib fractures in this population are often subtle, resulting from minimal trauma like coughing, and serve as predictors of future osteoporotic events, underscoring the condition's progressive impact on thoracic stability.^[46]^[47]^[48] Infectious processes affecting the rib cage include costochondritis, an inflammation of the costal cartilage at the rib-sternum junctions, typically idiopathic or linked to repetitive strain, viral infections, or autoimmune triggers. Pathophysiologically, it involves localized aseptic inflammation without systemic spread, causing reproducible tenderness and sharp, non-radiating chest pain aggravated by respiration, coughing, or upper body movement. Osteomyelitis of the ribs, conversely, represents a hematogenous or contiguous bacterial infection of the rib bone, often from Staphylococcus aureus, leading to cortical destruction, abscess formation, and periosteal reaction. It manifests as localized swelling, warmth, and severe pain, frequently accompanied by fever and elevated inflammatory markers, with indolent progression in pediatric or immunocompromised cases.^[49]^[50]^[51] Neoplastic involvement of the rib cage encompasses primary and metastatic tumors that disrupt normal architecture through uncontrolled proliferation. Chondrosarcoma, a primary malignant cartilage-derived tumor, originates in the rib's costal cartilage or perichondrium, driven by genetic mutations like IDH1/2 alterations that promote hyaline matrix production and low-grade invasion. It presents as a slowly enlarging, firm anterior chest wall mass with dull, progressive pain, potentially causing palpable deformity or pathologic fracture due to endosteal erosion. Metastatic lesions, commonly from breast or lung carcinomas, colonize the ribs via hematogenous dissemination, inducing osteolytic resorption through tumor-secreted factors like parathyroid hormone-related protein, which activates osteoclasts and elicits severe, localized bone pain from periosteal stretching and nerve compression. These metastases often deform the chest wall through expansile growth, with breast cancer favoring axial sites and lung cancer accounting for approximately 40% of bone metastases cases.^[52]^[53]^[54]^[55]^[56] Congenital deformities of the rib cage arise from aberrant chondral and osseous development during embryogenesis, influenced by genetic or connective tissue factors. Pectus excavatum features posterior depression of the sternum and adjacent ribs, stemming from excessive costal cartilage growth that displaces the sternum inward, thereby reducing intrathoracic volume in severe cases and restricting lung expansion. This condition, affecting approximately 1 in 300-400 individuals, may tie to anatomical variations in rib curvature and is often asymptomatic in mild forms but can link to syndromes with thoracic asymmetry. Pectus carinatum, by contrast, involves anterior protrusion of the sternum due to shortened or flared lower ribs and sternal eversion, resulting from unbalanced appositional growth at the costochondral junctions. It occurs in about 1 in 1,500 births and associates with Marfan syndrome through fibrillin-1 gene mutations that weaken elastic fibers, predisposing to chest wall instability alongside aortic risks.^[57]^[58]^[59]^[60] Across these diseases, patients commonly experience chest pain ranging from sharp and positional to chronic and aching, dyspnea due to mechanical restriction of thoracic excursion, and palpable masses or deformities that alter contour and evoke tenderness on examination. These manifestations, while overlapping, guide differential diagnosis, with pain often nocturnal in tumors, inflammatory in infections, and exertional in congenital cases.^[49]^[52]^[57]

Diagnostic and surgical aspects

Diagnosis of rib cage disorders primarily involves a combination of clinical assessment and imaging modalities to evaluate fractures, soft tissue injuries, and associated complications. Clinical examination begins with inspection and palpation to identify deformities, tenderness, crepitus, or abnormal chest wall movement, such as in flail chest, followed by auscultation to assess breath sounds and detect underlying pulmonary issues.^[61]^[62] Pain is quantified using standardized scales, like the Visual Analog Scale, to guide management and monitor progress.^[63] Pulmonary function tests, including spirometry, are employed to evaluate respiratory capacity and detect restrictive patterns resulting from rib injuries.^[64] Imaging plays a crucial role in confirming rib fractures and assessing extent. Conventional X-rays serve as the initial modality for detecting rib fractures, though they may miss nondisplaced or occult ones.^[65] Computed tomography (CT) scans provide detailed visualization, including 3D reconstructions for complex trauma, offering higher sensitivity for multiple fractures and associated injuries like pneumothorax.^[66] Magnetic resonance imaging (MRI) excels in evaluating soft tissues, cartilage, and stress fractures, particularly in cases of subtle or non-displaced injuries.^[67] Ultrasound is valuable for bedside detection of occult rib and costal cartilage fractures, as well as costochondritis, with advantages in portability and absence of radiation.^[68]^[69] Surgical interventions for rib cage pathologies aim to stabilize fractures, repair injuries, and remove pathological tissues while minimizing complications. Open reduction and internal fixation (ORIF) using plates and screws is the standard for flail chest, improving respiratory mechanics and reducing ventilator dependence.^[70]^[43] Thoracotomy is indicated for penetrating injuries requiring direct access to control hemorrhage or repair vital structures.^[71] Rib resection is performed for tumors, ensuring wide margins to achieve oncologic clearance, often via open or minimally invasive approaches.^[72] Video-assisted thoracoscopic surgery (VATS) enables minimally invasive fixation and exploration, reducing postoperative pain and recovery time compared to open techniques.^[73] Postoperative care emphasizes pain control to facilitate breathing and mobility. Intercostal nerve blocks, administered pre- or postoperatively, effectively reduce pain and opioid requirements following rib surgeries.^[74]^[75] These blocks target the intercostal nerves to provide targeted analgesia, with variants like rhomboid intercostal blocks showing efficacy in thoracic procedures.^[76]

Regeneration and repair

Natural healing processes

The natural healing of rib fractures follows the general stages of bone repair, beginning with hematoma formation immediately after injury, where disrupted blood vessels create a hematoma at the fracture site that serves as a scaffold for subsequent repair processes.^[77] This inflammatory phase lasts approximately 1 to 5 days, during which inflammatory cells are recruited to clear debris and initiate granulation tissue formation.^[78] Next, the reparative stage involves soft callus development over weeks 1 to 3, where fibroblasts and chondroblasts produce a fibrocartilaginous matrix that bridges the fracture gap and provides initial stability.^[77] This transitions to hard callus formation between weeks 3 and 12, as the soft callus undergoes endochondral ossification to form woven bone, restoring structural integrity to the rib.^[78] Finally, remodeling occurs over months to years, where the callus is reshaped into mature lamellar bone through balanced osteoblastic and osteoclastic activity, adapting to mechanical stresses from respiration and movement.^[77] Costal cartilage, which connects the ribs to the sternum, exhibits limited regenerative capacity compared to bone, primarily regenerating slowly through the differentiation of fibroblasts into chondrocyte-like cells that produce a matrix of collagen and proteoglycans.^[79] However, this process is inefficient due to the avascular nature of cartilage, often resulting in incomplete restoration and a propensity for calcification or ossification, which can lead to stiffness or deformity over time. Several factors influence the efficiency of rib cage healing. Advanced age impairs the process by reducing mesenchymal stem cell function, delaying chondrogenesis, and decreasing vascularization in the callus, leading to slower overall repair in elderly individuals.^[80] Nutritional status plays a key role, with deficiencies in vitamin D and calcium hindering mineralization and callus formation, while adequate intake supports osteoblast activity.^[81] Blood supply, primarily from the intercostal arteries branching from the thoracic aorta, is essential for delivering oxygen and nutrients to the fracture site; compromised perfusion can prolong healing. Potential outcomes of natural healing include successful union in most cases, but non-union occurs in 5-10% of rib fractures, often due to excessive motion at the site disrupting callus stability.^[82] Malunion, where the bone heals in a misaligned position, may result in chest wall deformity or chronic pain, particularly if involving multiple ribs.^[83]

Therapeutic interventions

Therapeutic interventions for rib cage repair primarily aim to alleviate pain, support healing, and prevent complications in cases of fractures, non-unions, or structural defects, building on the body's natural healing processes by incorporating medical and biological enhancements.^[84] Conservative approaches form the foundation of treatment for most rib fractures, focusing on pain control and respiratory support to facilitate recovery without invasive procedures. Nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, are recommended as first-line analgesics for isolated rib fractures due to their efficacy in reducing inflammation and pain while minimizing opioid-related risks.^[84] Opioids may be added for moderate to severe pain, particularly in multiple fractures, to enable deep breathing and mobility, though their use is limited to short durations to avoid dependency.^[85] Supportive measures like holding a pillow against the chest during coughing or movement act as a soft brace to stabilize the area and reduce discomfort.^[84] Respiratory therapy, including incentive spirometry, deep breathing exercises, and chest physiotherapy, is essential to expand lung volume, clear secretions, and prevent atelectasis, a common complication from shallow breathing due to pain.^[84]^[86] For cases of delayed union or non-union, advanced interventions incorporate biologics and grafting to promote osteogenesis and cartilage repair. Bone autografts, harvested from the patient's iliac crest and secured with locking plates, provide structural support and biological cues for healing in symptomatic rib non-unions, offering a reliable alternative to resection.^[87] Stem cell injections, typically mesenchymal stem cells derived from bone marrow, target non-union sites to enhance cellular proliferation and differentiation, accelerating bone regeneration when combined with scaffolds or growth factors.^[88] Platelet-rich plasma (PRP), an autologous concentrate of growth factors, is injected to stimulate callus formation and increase cartilage content in rib fractures, improving mechanical strength during early healing phases.^[89] Emerging therapies leverage advanced manufacturing and genetic approaches for complex defects, though many remain in preclinical or early clinical stages as of 2025. Custom 3D-printed titanium or polyethylene rib implants enable precise reconstruction of large chest wall defects post-resection or trauma, matching patient anatomy to restore respiratory mechanics and reduce operative time. In 2025, resorbable 3D-printed composite plates using fumarate-based copolyester-hydroxyapatite have been developed for surgical stabilization of rib fractures (SSRF), showing reduced inflammation in preclinical models.^[90]^[91]^[92] Gene therapy targeting ossification defects, such as delivery of BMP-2 cDNA via viral vectors, shows promise in preclinical models for enhancing endochondral bone formation in rib-like structures, but human trials are limited to broader bone healing applications.^[93] Clinical outcomes of these interventions demonstrate improved recovery metrics, with biologics like PRP and stem cells accelerating healing in fracture models compared to standard care, as evidenced by earlier radiographic union.^[94] Complications, including surgical site infections, occur in 2-5% of cases involving grafts or implants, often managed with antibiotics, while conservative methods carry lower risks but may prolong recovery in severe injuries.^[95]

Comparative and evolutionary aspects

In non-human animals

In mammals, the rib cage exhibits variations adapted to diverse locomotor and environmental demands. For instance, quadrupedal species like dogs possess 13 pairs of ribs, compared to the 12 pairs in humans, allowing for a broader thoracic attachment that supports quadrupedal posture and locomotion.^[96] In cetaceans such as whales, the ribs are broad, flat, and loosely articulated with overlapping segments forming a flexible, collapsible structure that compresses under hydrostatic pressure during deep dives, facilitating streamlined body form and lung adaptation without fracturing.^[97] Birds display specialized rib cage features optimized for flight and high metabolic rates. The sternum features a prominent keel-shaped projection that serves as the primary anchorage for the large pectoral flight muscles, enabling powerful wing downstrokes essential for aerial locomotion.^[98] Additionally, most bird ribs bear caudal uncinate processes—bony extensions that function as levers to enhance the mechanical advantage of intercostal muscles, stabilizing the thoracic basket and improving respiratory efficiency during sustained flapping.^[99] Among reptiles, rib cage morphology reflects extreme adaptations for protection and flexibility. In turtles, the thoracic ribs are broadened, ossified, and fused directly with the vertebrae and overlying dermal plates to integrate into the rigid carapace, forming a bony enclosure that shields vital organs while limiting respiratory excursion.^[100] Conversely, snakes exhibit a highly elongated and reduced rib cage, with up to 200–400 pairs of slender, floating ribs extending along most trunk vertebrae but lacking a sternum or closed basket; this configuration prioritizes lateral flexibility for sinuous locomotion over thoracic rigidity.^[101] These anatomical variations underscore functional specializations across species. In armored mammals like armadillos, the standard mammalian rib cage of approximately 10–12 pairs is secondarily protected by an overlying dermal bony shield (carapace) composed of osteoderms, enhancing defense against predators while maintaining internal organ enclosure.^[102] In birds, the rib cage supports elevated respiratory demands of endothermy and flight, with uncinate processes facilitating rapid, unidirectional airflow through air sacs for oxygen delivery during high-energy exertion.^[99]

Evolutionary development

The rib cage in vertebrates traces its origins to the axial skeleton of early fish-like ancestors around 500 million years ago, where rudimentary rib-like structures emerged from ventral projections known as basapophyses on the trunk vertebrae, providing structural support to the body wall rather than forming a protective enclosure.^[103] These elements, associated with neural arches that enclose the spinal cord, were primarily adapted for locomotion in aquatic environments and did not yet constitute a cage-like structure. By the late Devonian period approximately 375 million years ago, during the transition to tetrapods, significant modifications occurred: ventral ribs were largely lost, and dorsal ribs evolved from parapophyses and diapophyses derived from neural arch components, forming a dual-articulated system that created a protective thoracic basket around emerging lungs and the heart.^[103] This innovation coincided with the shift to terrestrial life, enhancing body rigidity and organ protection during weight-bearing movement on land. In mammalian evolution, the number of rib pairs increased from the ancestral tetrapod condition, with early mammals typically possessing 13 pairs attached to thoracic vertebrae, reflecting adaptations for expanded thoracic volume and respiratory demands in warm-blooded metabolism. However, in the hominin lineage within primates, this number reduced to 12 pairs, a change linked to the evolution of bipedalism, which favored a more flexible lumbar region and narrower thorax to optimize balance and energy efficiency during upright locomotion. This reduction is evident in comparisons between early primates and modern hominoids, where the loss of one thoracic vertebra allowed for proportional adjustments in spinal curvature. Within hominids, the rib cage underwent further adaptations, becoming broader and more barrel-shaped in the genus Homo compared to earlier australopithecines, accommodating the demands of fully upright posture and increased locomotor efficiency. Fossil evidence from Homo erectus, such as the Nariokotome Boy, indicates a conical upper thorax transitioning to a wider lower portion, which supported greater shoulder mobility and respiratory capacity essential for sustained activities. Modern humans exhibit pronounced sexual dimorphism in rib cage morphology, with males having broader and deeper cages to facilitate upper body strength, while females show narrower forms potentially linked to obstetric adaptations, though this dimorphism emerged gradually in the Homo lineage. These evolutionary changes were driven by selective pressures in human ancestors, including protection against falls during arboreal lifestyles in early primates, where a robust rib cage mitigated impact injuries to vital organs. Later, in open savanna environments, enhancements to the rib cage supported respiratory efficiency during endurance running, a key hunting strategy in early Homo, by allowing greater thoracic expansion and integration with diaphragm-driven ventilation for prolonged aerobic exertion.

Cultural and historical context

Representations in society

The rib cage has been a subject of fascination in artistic representations since the Renaissance, with Leonardo da Vinci producing detailed anatomical sketches in the early 1500s that illustrated its mechanical structure and muscular interactions. In one notable drawing from around 1510, da Vinci depicted the full human skeleton, emphasizing the rib cage's vertebral curvature, oblique rib placements, and articulations with the sternum and clavicles, though he included minor inaccuracies such as overly acute angles on the first two ribs and exaggerated thorax depth. Another sketch highlighted the intercostal muscles, distinguishing the external intercostals (fibers oriented downward from left to right) that elevate the ribs to expand the chest cavity during inhalation, and the internal intercostals (fibers downward from right to left) that depress the ribs for exhalation, marking the first known differentiation of their opposing functions.^[104] These works, created during da Vinci's studies in Milan and Florence, applied engineering principles to human anatomy, influencing later bioengineering and medical visualization. Modern medical illustrations build on this tradition, employing digital 3D modeling and vector diagrams to depict the rib cage's structure with precision for educational and diagnostic purposes, such as labeled diagrams showing the 12 pairs of ribs, sternum, and costal cartilages in anterior and lateral views.^[105] In contemporary society, the rib cage features prominently in symbolic and aesthetic expressions, particularly through tattoos that outline its skeletal form along the torso, often chosen for their intimate placement and to evoke themes of resilience and enclosure. These designs draw on the rib cage's inherent role as a protective barrier, appearing in intricate line work or realistic shading to symbolize personal strength or vulnerability. Historically, fashion practices like Victorian-era corseting altered the rib cage's shape through prolonged tight lacing, compressing the lower ribs into a more conical form and deforming the skeletal structure, as evidenced by anthropological analyses of 19th-century remains showing circular rib cages and spinal misalignments.^[106] Such modifications, driven by ideals of an hourglass silhouette, compressed the torso and reduced lung capacity, highlighting cultural pressures on body modification.^[107] Media portrayals frequently emphasize the rib cage's vulnerability, with injury scenes in action films depicting fractures or trauma to underscore character pain and physical limits, as seen in sequences where impacts lead to labored breathing and restricted movement. Educational models further represent the rib cage in society, using life-size, flexible replicas cast from human specimens to demonstrate its articulation with the spine and pelvis, aiding in classroom instruction on thoracic anatomy and biomechanics.^[108] Historical practices also involved ritualistic manipulation of the ribs, such as the Viking "blood eagle" execution method from the 8th to 11th centuries, where captors severed the ribs from the spine through the back to expose the lungs in a symbolic act of vengeance, as described in Norse sagas, though its historical occurrence is debated among scholars due to the lack of archaeological evidence and questions regarding the reliability of the textual accounts.^[109] These depictions collectively reflect the rib cage's dual role as both a shielded guardian and a site of dramatic exposure in cultural narratives.

Religious and mythological references

In the Book of Genesis within the Hebrew Bible, the creation of the first woman, Eve, is recounted as occurring from one of Adam's ribs. According to Genesis 2:21-22, God caused a deep sleep to fall upon Adam, took one of his ribs, and closed up the flesh in its place, then formed the rib into a woman and presented her to the man.^[110] This narrative appears in various midrashic interpretations in Jewish tradition, where the rib extraction is sometimes described as occurring without Adam's awareness to emphasize divine intent in human companionship. For instance, Rabbi Yose in the Genesis Rabbah suggests God took the rib surreptitiously, highlighting the benefits Adam received through Eve's creation despite any initial loss.^[111] In Islamic tradition, a hadith attributed to the Prophet Muhammad reinforces a similar motif, stating that women were created from a rib, with the most curved portion at its upper end. Narrated by Abu Hurairah in Sahih al-Bukhari and other collections, the hadith advises men to treat women kindly, as attempting to straighten the rib would break it, while leaving it intact allows it to remain functional in its natural form. This analogy underscores themes of inherent differences and the importance of patience in marital relations.^[112] Theological debates surrounding the rib creation story often center on whether the account is literal or metaphorical, with implications for gender roles and equality. Some scholars interpret the Hebrew term tsela (translated as "rib") more broadly as "side," suggesting an original androgynous human divided into male and female counterparts to symbolize partnership rather than hierarchy.^[113] Others view it literally but emphasize equality, arguing the rib's origin from Adam's side—neither head nor foot—indicates women as companions standing alongside men.^[114] These interpretations have historically influenced views on gender complementarity, countering notions of female subordination by framing the creation as one of mutual interdependence.^[115]

References

[1]
Anatomy, Thorax, Ribs - StatPearls - NCBI Bookshelf - NIH
The ribs are the bony framework of the thoracic cavity. Generally, there are twelve pairs of ribs. Each rib articulates posteriorly with two thoracic vertebrae.
[2]
The Thoracic Cage – Anatomy & Physiology - UH Pressbooks
The thoracic cage consists of 12 pairs of ribs with costal cartilages and the sternum, which protects the heart and lungs. Ribs are anchored to the thoracic ...
[3]
Bones of the Thorax - TeachMeAnatomy
The bones of the thorax are the ribs, the sternum, and the thoracic spine. The ribcage has 12 paired ribs, the sternum is a flat bone, and the spine has 12 ...
[4]
Ribs - Physiopedia
According to their attachment to the sternum, the ribs are classified into 3 groups: true, false, and floating ribs. The true ribs are the ribs that directly ...
[5]
Anatomy, Thorax, Sternum - StatPearls - NCBI Bookshelf
Jul 24, 2023 · The sternum is a partially T-shaped bone forming the chest wall, divided into manubrium, body, and xiphoid process, and protects the ...Introduction · Structure and Function · Embryology · Physiologic Variants
[6]
7.4 The Thoracic Cage - Anatomy and Physiology 2e | OpenStax
Apr 20, 2022 · Parts of a Typical Rib Lateral to the head is the narrowed neck of the rib. A small bump on the posterior rib surface is the tubercle of the ...
[7]
Typical ribs | Radiology Reference Article - Radiopaedia.org
Nov 16, 2020 · Gross anatomy. A typical rib is long and flat. They contain a: head; neck; tubercle; shaft; angle. Ribs have a rounded, smooth superior ...Missing: human structure
[8]
Costovertebral joint | Radiology Reference Article - Radiopaedia.org
Oct 7, 2020 · Costovertebral Joint · intra-articular ligament - attaches the intervertebral disc to the ridge in between the two facets of the head of the rib.
[9]
Ligaments of the Costovertebral Joints including Biomechanics ...
Nov 11, 2016 · The costovertebral ligaments are dense, fibrous ligaments, and the majority of fibers run in a uniform direction. They have an ample amount of ...
[10]
CT of Rib Lesions | AJR - American Journal of Roentgenology
Anteriorly, the costal cartilages of the first ribs attach directly to the manubrium by synchondroses, the second through seventh ribs articulate with the ...
[11]
Paraxial Mesoderm: The Somites and Their Derivatives - NCBI - NIH
Somites give rise to the cells that form the vertebrae and ribs, the dermis of the dorsal skin, the skeletal muscles of the back, and the skeletal muscles of ...
[12]
[PDF] Hox genes control vertebrate body elongation by collinear Wnt ...
Feb 26, 2015 · Here, we first investigate the relationship between the speed of somite formation and of axis elongation. We show that, in the chicken embryo, ...
[13]
[PDF] hox function in mammalian kidney development
Hox5, Hox6 and Hox9 mutants all have smaller rib cages than controls. As the size of the rib cage is a product of contributions from both the somite-derived,.
[14]
Rib Cage Morphogenesis in the Human Embryo: A Detailed Three ...
Jul 25, 2019 · No ossification was observed in any of the 12 thoracic vertebrae or rib pairs during the entire embryonic period (including CS23).
[15]
Paper - On Ossification Centers in Human Embryos
Jul 20, 2018 · During the 55th day the ribs make their appearance, and judging by their size, it is the 6th and 7th which ossify first. The ossification ...Missing: secondary | Show results with:secondary
[16]
1 Thoracic Wall
Mar 16, 2021 · Secondary ossification centers appear for the head and tubercle of the rib at puberty. The 11th and 12th ribs have no necks or tubercles. The ...Missing: postnatal | Show results with:postnatal
[17]
Endochondral Ossification - an overview | ScienceDirect Topics
Endochondral ossification is the mechanism responsible for the formation of all long bones of the axial skeleton (vertebrae and ribs) and the appendicular ...
[18]
Evaluation of sternum postnatal development & variations with CT
The ossification centers in the manubrium generally merge before birth. Two or more ossification centers that develop on each segment of the mesosternum (body) ...
[19]
An overview of PAX1: Expression, function and regulation in ... - NIH
In addition, the proximal part of the ribs are missing or severely malformed in Pax1 mutant mice (Wallin et al., 1994), suggesting an essential role of Pax1 for ...
[20]
Maternal smoking in pregnancy and birth defects - PubMed Central
Maternal smoking is associated with a significant increased risk for defects of the cardiovascular, musculoskeletal and gastrointestinal systems, the face ...Missing: rib cage
[21]
≤11 ribs (differential) | Radiology Reference Article - Radiopaedia.org
Sep 12, 2021 · ≤11 ribs is associated with a number of congenital abnormalities and skeletal dysplasias, including: Down syndrome (trisomy 21) ...<|control11|><|separator|>
[22]
Anatomical variations and congenital anomalies of the ribs revisited ...
The ribs are classified as true when they articulate directly to the sternum through their respective costal cartilages (synchondrosis in the first rib and ...Missing: attachments | Show results with:attachments
[23]
Frequency of Sternal Variations and Anomalies Evaluated by MDCT
Sternal foramen located in the corpus was found in 45 (4.5%) subjects. All were present in the inferior part of the sternal body. The size of sternal foramina ...
[24]
Anatomy, Thorax, Cervical Rib - StatPearls - NCBI Bookshelf
Cervical ribs tend to occur in approximately 0.5 to 1% of the population. They are commonly attached to the seventh cervical vertebra.
[25]
Sexual dimorphism of human ribs - PubMed
The volume of the rib cage is about 10% smaller in females than in males having the same height although the reason for this is presently unclear.
[26]
The prevalence of cervical ribs in a London population - PubMed
Our study found that the overall prevalence of cervical ribs was 0.74% with a higher rate in females compared with males (1.09 and 0.42%, respectively).
[27]
Anatomy, Thorax, Wall Movements - StatPearls - NCBI Bookshelf - NIH
The thoracic wall protects the heart, lungs, great vessels, and some abdominal organs. Additionally, the bony structures provide attachment points for muscles ...Anatomy, Thorax, Wall... · Blood Supply And Lymphatics · Muscles<|control11|><|separator|>
[28]
Biomechanics of the Thorax - Physiopedia
Motion of sternum resembles pump handle movement, hence the name. Lower ribs elevate; Motion is more in the lateral part of ribs due to its more angled shape ...Anatomy · Function of Thorax · Kinematics · Muscles involved in respiration
[29]
Human Chest Wall Function During Epidural Anesthesia - PubMed
Therefore, high EA decreased the percentage contribution of rib cage expansion to inspiratory increases in thoracic volume (delta Vth) (from 27 +/- 2 [MSE] to ...
[30]
Geometry and respiratory displacement of human ribs
The pump handle and bucket handle components of rotation are 11 and 13 degrees ... rotation and the midplane are approximately 35 degrees for all 5 ribs.
[31]
Rib Cage (Thoracic Cage): What It Is, Anatomy & Function
Oct 29, 2024 · Types of ribs · True ribs (vertebrosternal ribs). · False ribs (vertebrochondral ribs). · Floating ribs (vertebral ribs or free ribs). · Typical ...
[32]
7.4 The Thoracic Cage – Anatomy & Physiology 2e
The thoracic cage protects the heart and lungs. It is composed of 12 pairs of ribs with their costal cartilages and the sternum. The ribs are anchored ...Sternum · Ribs · Rib Classifications
[33]
Thoracic cage: Anatomy and clinical notes | Kenhub
Thoracic cage ; Structural components, 12 thoracic vertebrae with their intervertebral discs, 12 pairs of ribs and their associated costal cartilages and sternum.Subcostal muscles · Tubercle of rib · Pectoralis major muscle · Intercostal nerves
[34]
Functional Anatomy of the Thoracic Spine and Rib Cage - Physiopedia
This article discusses the key anatomical structures of the thoracic vertebrae and rib cage, including the bony structures, articulations, ligaments, muscles, ...
[35]
How Does the Rib Cage Affect the Biomechanical Properties of the ...
Jun 14, 2022 · The rib cage increases the thoracic spinal stability in all motion planes, primarily in axial rotation and predominantly in the upper thorax half.
[36]
How Does the Rib Cage Affect the Biomechanical Properties of the ...
Jun 15, 2022 · The rib cage increases the thoracic spinal stability in all motion planes, primarily in axial rotation and predominantly in the upper thorax half.Missing: limbs | Show results with:limbs
[37]
Anatomy, Thorax, Intercostal Nerves - StatPearls - NCBI Bookshelf
May 22, 2023 · [3] Each posterior intercostal artery travels along the bottom of the rib with a corresponding posterior intercostal vein and intercostal nerve.Introduction · Structure and Function · Blood Supply and Lymphatics · Nerves
[38]
Intercostal arteries and blood supply of thoracic wall - Kenhub
The intercostal arteries that travel in the intercostal spaces and the internal thoracic arteries supply with blood the thoracic cage.
[39]
Intercostal veins: Anatomy, drainage, clinical aspects - Kenhub
The neurovascular bundle of each rib consists of the intercostal artery, vein and nerve. The neurovascular bundle runs directly under the lower border of each ...
[40]
Rib Fracture - StatPearls - NCBI Bookshelf
Aug 8, 2023 · Rib fractures can be traumatic or atraumatic. Most rib fractures are due to direct penetrating or blunt trauma to the chest.
[41]
Rib Fracture: Background, Pathophysiology, Etiology
May 15, 2025 · The most common mechanism of injury for rib fractures in elderly persons is a fall from a height or from standing. In adults, a motor vehicle ...
[42]
Traumatic rib fractures: a marker of severe injury. A nationwide study ...
Jun 10, 2020 · The highest mortality rate was observed among patients with flail chest (13.0%), followed by patients with polytrauma (10.6%) and elderly ...
[43]
Flail Chest - StatPearls - NCBI Bookshelf
Jun 22, 2025 · Reported mortality ranges from 10% to 20%, often attributable to associated injuries rather than flail chest itself.[3] Morbidity is substantial ...Continuing Education Activity · Epidemiology · Evaluation · Treatment / Management
[44]
Operative fixation of rib fractures after blunt trauma - Lippincott
Rib fractures are identified in 10% of all injury victims and are associated with significant morbidity (33%) and mortality (12%).
[45]
Risk of Subsequent Fractures in Postmenopausal Women After ...
Jun 7, 2021 · One in 2 postmenopausal women will have an osteoporosis-related fracture during their remaining lifetimes. Fractures can result in loss of ...
[46]
Rib fracture as a predictor of future fractures in young and older ...
Sep 9, 2011 · Emerging evidence suggests rib fracture may be an osteoporotic fracture in men and women. We report the 5-year independent association between ...
[47]
Cough-Induced Rib Fracture in a Postmenopausal Woman Without ...
Dec 9, 2024 · Osteoporosis is a common condition in postmenopausal women, and it can increase the risk of fractures from minimal force [7]. Although ...
[48]
Costochondritis - StatPearls - NCBI Bookshelf - NIH
Costochondritis is a benign cause of chest wall pain from costal cartilage inflammation at the rib-to-sternum articulation.Continuing Education Activity · Introduction · Epidemiology · Differential Diagnosis
[49]
Osteomyelitis of the Rib in a Child With Indolent Symptoms - PMC
Apr 5, 2022 · Thirdly, the clinical presentation includes fever accompanied by pain at the site of infection; in the case of rib involvement, this may present ...
[50]
RIB OSTEOMYELITIS: A RARE COMPLICATION OF VARICELLA - NIH
The most frequent complication is bacterial infection of cutaneous lesions. Osteoarticular complications are rare, and rib osteomyelitis is described in less ...
[51]
Chondrosarcoma of the Ribs - PMC - PubMed Central - NIH
Jul 12, 2020 · The patients with CS generally complain of and present signs and symptoms of swelling or palpable mass with increasing pain and fracture due to ...
[52]
Chondrosarcoma - StatPearls - NCBI Bookshelf - NIH
Local swelling and pain are the most common presenting symptoms. The symptoms are usually of long duration (months to years). Tumors located in the skull base ...Missing: cage | Show results with:cage
[53]
Bone and brain metastasis in lung cancer - PubMed Central - NIH
Many factors are implicated in the pain of osseous metastases but a significant portion of the pain seems to be related to osteoclastic bone resorption.
[54]
The Burden of Metastatic Cancer–Induced Bone Pain
Oct 25, 2022 · Metastatic cancer–induced bone pain (mCIBP) is caused by inflammation and bone remodeling (nociceptive pain) or by damage to or dysfunction of ...
[55]
Pectus excavatum - Symptoms and causes - Mayo Clinic
Mar 14, 2025 · Pectus excavatum is a condition in which the breastbone is sunken into the chest. If the condition is very serious, it can affect how well the heart and lungs ...Missing: volume | Show results with:volume
[56]
Improvement of cardiopulmonary function after minimally invasive ...
Pectus excavatum, also known as funnel chest or sunken chest, is by far the most common congenital chest wall deformity, occurring in approximately one in ...
[57]
Pectus Carinatum - StatPearls - NCBI Bookshelf
Pectus carinatum or “keel chest,” like its sister condition pectus excavatum, is a congenital deformation of the anterior chest wall.Introduction · History and Physical · Treatment / Management · Differential Diagnosis
[58]
Pectus updates and special considerations in Marfan syndrome - PMC
Pectus deformities including pectus excavatum (funnel chest) and pectus carinatum (pigeon chest) constitute the most common congenital anterior chest wall ...
[59]
Chest Examination - Clinical Methods - NCBI Bookshelf - NIH
Palpation, confirmed by percussion, assesses for tenderness and degree of chest expansion. Auscultation, a more sensitive process, confirms earlier findings and ...Missing: scales | Show results with:scales
[60]
Essentials of Physiotherapy after Thoracic Surgery - PubMed Central
Clinical examination: inspection, palpation, percussion, and auscultation. Method of pain control: the physiotherapist must be aware of the various routes of ...1) Physiotherapy Pain... · 4) Lung Expansion Manoeuvres · 5) Airway Clearance...<|control11|><|separator|>
[61]
Chapter 10 Musculoskeletal System Alterations - NCBI - NIH
Pain Management. Nurses assess client's pain levels using pain scales to effectively manage pain and evaluate the effectiveness of pain medications and ...
[62]
Surgical stabilization of rib fractures (SSRF): the WSES and CWIS ...
The improvement in pulmonary function tests and lower thoracic deformity and pain were confirmed in FC patients undergoing SSRF in some prospective studies ...
[63]
Thoracic wall trauma—misdiagnosed lesions on radiographs and ...
Aug 2, 2017 · This article describes different types of traumatic events affecting the chest wall, which maybe misdiagnosed with conventional X-ray.Missing: cage | Show results with:cage
[64]
Low-dose CT examination for rib fracture evaluation: A pilot study
Jul 27, 2018 · The aim of this study was to assess the applicability of low-dose thoracic computed tomography (CT) in the diagnosis of rib fractures.Missing: cage | Show results with:cage
[65]
Magnetic Resonance Imaging has Better Accuracy in Detecting New ...
MRI is highly sensitive for new-onset rib fractures, especially type I, so it is a preferred method for patients with mild chest trauma.Missing: ultrasound | Show results with:ultrasound
[66]
Sonography of Occult Rib and Costal Cartilage Fractures - NIH
The purpose of this case series is to describe the use of diagnostic ultrasound (US) in the detection of occult rib and costal cartilage fractures.
[67]
Performance of thoracic ultrasonography compared with chest ...
Mar 19, 2024 · Conclusion: Ultrasonography appeared to be superior to X-ray for the detection of rib fractures with regard to a reference CT.Missing: MRI | Show results with:MRI
[68]
Surgical Stabilization of Rib Fractures: Indications, Techniques, and ...
May 7, 2020 · We often perform VATS prior to SSRF. The purpose of VATS is to control the intercostal vessel bleeding, evacuate hematomas, wash out the chest ...
[69]
Immediate thoracotomy for penetrating injuries: ten years ... - NIH
A small but significant group of 10–15 % of patients with penetrating thoracic injuries require an immediate thoracotomy as part of their initial resuscitation.
[70]
Rib resection using a pneumatic high-speed power drill system for ...
Abstract. Rib resection for chest wall tumors, including lung cancer with chest wall invasion, is usually performed through open thoracotomy.
[71]
Completely thoracoscopic surgical stabilization of rib fractures - NIH
Completely thoracoscopic SSRF, which refers to using a video-assisted thoracoscopic surgery (VATS) technique to both reduce and fixate rib fractures in an ...Missing: cage | Show results with:cage
[72]
Role of intercostal nerve block in reducing postoperative pain ... - NIH
Patients receiving intercostal nerve block have better pain control and less morphine consumption as compared to those patients who did not receive intercostal ...
[73]
Intercostal Nerve Block - StatPearls - NCBI Bookshelf
An intercostal nerve block is simple to perform and useful for pain management, either as a primary intervention or as an adjunct.
[74]
The Effectiveness and Safety of Rhomboid Intercostal Block for ...
Rhomboid intercostal block provides effective pain reduction and lowers opioid consumption within 24 hours post-surgery, while also minimizing PONV rates.
[75]
Fracture Healing Overview - StatPearls - NCBI Bookshelf
Apr 8, 2023 · Fracture healing is complex, and it involves the following stages: hematoma formation, granulation tissue formation, callus formation, and bone remodeling.Missing: rib | Show results with:rib
[76]
Fracture healing | Radiology Reference Article - Radiopaedia.org
Nov 25, 2022 · Fracture healing occurs naturally after traumatic bony disruption. This process begins with hemorrhage and progresses through three stages.
[77]
An enhanced method of rapid cartilage healing after costal cartilage ...
This study shows that autologous cartilage pieces left in the perichondrial space accelerate cartilage regeneration and lead to spontaneous self-oriented ...
[78]
Effects of Aging on Fracture Healing - PMC - PubMed Central
Aging affects the inflammatory response during fracture healing through senescence of the immune response and increased systemic pro-inflammatory status.
[79]
Acute and Chronic Rib Conditions | MUSC Health | Charleston SC
Recovery from injury requires good nutrition and blood flow to the injured areas. Some patients benefit from taking calcium and vitamin D. The use of tobacco ...Acute Rib Fractures · Non-Healing Rib Fractures · Slipped Rib Syndrome
[80]
Review Management of non-union of rib fractures secondary to trauma
The rate of non-union is estimated to be between 5 and 10 %, but is not well studied for rib fractures [4,5].
[81]
To fix or let them flail: the who, what and when of rib fixation
Apr 14, 2025 · Non-union or malunion of rib fractures. Non-union affects a significant number of rib fractures 6 months postinjury.28 Non-union and malunion ...<|control11|><|separator|>
[82]
Initial evaluation and management of rib fractures - UpToDate
Jan 14, 2025 · Holding a pillow or similar soft brace against the fracture site reduces discomfort while using the spirometer or when coughing or sneezing.
[83]
Chest Trauma: Current Recommendations for Rib Fractures ... - NIH
Jan 15, 2020 · Chest wall pain resulting from multiple rib fractures can exacerbate pulmonary complications associated with blunt thoracic injury.Missing: cage | Show results with:cage
[84]
Effect of respiratory training intervention on rehabilitation of patients ...
Mar 24, 2025 · Respiratory training interventions significantly benefit patients with rib fractures by reducing atelectasis and pulmonary infections, shortening hospital ...
[85]
Bone Autograft Coupled with Locking Plates Repairs Symptomatic ...
Jun 1, 2018 · Operative fixation and bone autograft should be considered as a viable technical alternative to resection alone for rib nonunion. MeSH terms.
[86]
Adult Stem Cells for Bone Regeneration and Repair - PMC - NIH
Nov 12, 2019 · To this purpose, stem cells are often employed with biomaterials/scaffolds and growth factors to accelerate bone healing at the fracture site.
[87]
Platelet-rich plasma enhances rib fracture strength and callus ... - NIH
Sep 6, 2024 · In addition, PRP has been shown to improve the body's capacity for soft-tissue and cartilaginous healing via acceleration of cell proliferation ...Missing: grafts | Show results with:grafts
[88]
Customized 3-dimensional printed rib plating in chest wall ...
Both patients underwent their surgeries within 2 weeks of 3D printing of the implants, and we did not encounter inaccurate margins intraoperatively or the need ...
[89]
Chest wall reconstruction with an anatomically designed 3-D printed ...
Sep 25, 2020 · We describe the reconstruction of a large skeletal defect with a three-dimensional (3-D) printed custom-made, anatomically designed, titanium alloy ribs and ...
[90]
Gene Therapy for Bone Healing: Lessons Learned and New ... - NIH
May 5, 2021 · Data from experiments in small animal models confirm that intra-lesional delivery of BMP-2 cDNA is able to heal defects efficiently and safely ...Missing: cage | Show results with:cage
[91]
Methods to accelerate fracture healing – a narrative review ... - NIH
Jun 7, 2024 · The results showed a 30% decrease in fracture-healing time in the intervention group (2.4 months) compared to the control group (3.6 months). ...Missing: biologics | Show results with:biologics
[92]
Randomized controlled trial of surgical rib fixation to non-operative ...
A median of 4 (4–5) ribs were stabilized at each procedure. Surgical complications of seroma (1 [2%]) and surgical site infection (1 [2%]) were rare but ...
[93]
How Many Ribs Do Dogs Have? Vet-Approved Anatomy Facts & Info
Jan 23, 2025 · While humans have 12 pairs of ribs, dogs have 13, with 9 true ones, 3 false ones, and a floating rib.
[94]
Anatomical adaptations of aquatic mammals - Reidenberg
May 21, 2007 · A jointed, collapsible rib cage allows compression of the thorax to accommodate the shrinking lungs. Skeletal muscles are adapted to ...
[95]
The relationship between sternum variation and mode of locomotion ...
Aug 19, 2021 · We show that a large sternum with a deep or cranially projected sternal keel is necessary for powered flight in modern birds.
[96]
Functional significance of the uncinate processes in birds
Nov 15, 2007 · The model demonstrates that uncinates act as levers, which improve the mechanical advantage for the forward rotation of the dorsal ribs.
[97]
The evolutionary origin of the turtle shell and its dependence on the ...
Jun 5, 2014 · The turtle carapace is formed through modification of the thoracic ribs and vertebrae, which undergo extensive ossification to form a solid bony structure.
[98]
From Lizard to Snake; Behind the Evolution of an Extreme Body Plan
In comparison, the snake has a huge increase in vertebrae number, lacks limbs, displays an extensive homogenous rib-bearing region (dorsal vertebrae/thorax) ...
[99]
Dorsal view of the skeleton in armadillos: ( A ) Dasypus kappleri ...
Ossi fi cation spreads cranially from the upper lumbar region and caudally from the upper thoracic region to meet at the middle of the rib cage (Fig. 1 C ) ...
[100]
6. Vertebral Column and Turtle Shells
The vertebral column plays a key role in snake locomotion, and as a result, the vertebrae of most snakes are complex. The atlas/axis complex is much like that ...
[101]
Leonardo da Vinci: engineer, bioengineer, anatomist, and artist
Drawing of the rib cage with the intercostal muscles (K/P 47v). The center drawing shows the external intercostal muscles while the drawing on the right shows ...
[102]
3D Skeletal System: Bones of the Thoracic Cage - Visible Body
Oct 24, 2012 · Ever wondered what life would be like without your rib cage? You shouldn't. Read on to find out more about this vital part of the axial ...
[103]
Here's How Corsets Deformed The Skeletons Of Victorian Women
Nov 16, 2015 · Corseting of the waist to make an hourglass figure left lasting effects on the skeleton, deforming the ribs and misaligning the spine.
[104]
The dangers of tight lacing: the effects of the corset
Feb 17, 2017 · Tight lacing caused breathing issues, poor digestion, back muscle atrophy, deformed rib cage, and was considered a health hazard by compressing ...
[105]
https://www.visiblebody.com/blog/3d-skeletal-system-bones-of-the-thoracic-cage
[106]
Vikings' 'blood eagle' torture was horrific — and may have actually ...
Jan 27, 2022 · Captors would cut and open large flaps of skin and muscle from their living victim's back and then sever the ribs from the spine, opening the ...
[107]
The Adam and Eve Story: Eve Came From Where?
The Adam and Eve story states that God formed Adam out of dust, and then Eve was created from one of Adam's ribs. Was it really his rib?<|separator|>
[108]
Eve: Midrash and Aggadah | Jewish Women's Archive
According to R. Yose, God did indeed take Adam's rib surreptitiously, but he received manifold benefit when God gave him Eve. In this midrashic retelling, the ...
[109]
Meaning of the hadith, “Treat women kindly” - Islam Question ...
Jul 9, 2001 · The hadith says, “Treat women kindly, for woman was created from a bent rib, and the most crooked part of the rib is the top part…
[110]
Is the translation "rib" for the Hebrew צֵלָע (*tsela*) in Genesis 2 ...
Sep 30, 2015 · Some scholars believe that Adam was created both male and female as denoted in Genesis 1:27 and that God literally removed the female part of ...
[111]
Adam's Rib - Women In The Scriptures
Jun 3, 2009 · Eve was taken from Adam's rib because she was his equal and God intended for her to stand beside him– not below him, not behind him and not above him.Missing: theological debates metaphorical gender
[112]
Less Obnoxious Interpretations of Adam and Eve - Exponent II Blog
Less Obnoxious Interpretations of Adam and Eve ; The creation of Eve from Adam's rib is a symbol of men and women walking side by side as equal partners. Lessons ...