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Biorobotics

Biorobotics is an interdisciplinary field that integrates principles from biology, robotics, and engineering to design, develop, and apply robotic systems inspired by or incorporating biological mechanisms, such as biohybrid devices that combine living tissues with synthetic components.^[1] This field encompasses the creation of robots that mimic natural locomotion, sensory capabilities, and adaptability, as well as tools for studying biological processes through engineered models.^[2] At its core, biorobotics draws on advancements in materials science, cybernetics, and nanotechnology to produce soft, flexible robots capable of navigating complex environments, much like animals or human tissues.^[3] Key innovations include artificial muscles, such as pneumatic actuators (e.g., McKibben muscles achieving up to 25% contraction) and electroactive polymers, which enable precise, biomimetic movements for applications in rehabilitation and surgery.^[3] Biohybrid systems, like xenobots formed from frog embryonic cells and anthrobots from human tracheal cells, demonstrate emergent behaviors such as kinematic self-replication, collective motion, motility, and tissue repair, bridging synthetic engineering with developmental biology.^[4]^[5] Notable applications span medical robotics, where minimally invasive devices like capsular endoscopes facilitate gastrointestinal diagnostics, and assistive technologies, including powered prosthetics enhanced by artificial sensing skins to restore mobility.^[6] In environmental and exploratory contexts, bio-inspired robots modeled on cockroach gaits, such as those using jittering motions, enable robust traversal of uneven terrains, while microrobots target drug delivery within circulatory systems.^[7] These developments highlight biorobotics' role in advancing both scientific understanding of life processes and practical solutions for human health challenges.^[8]

Overview

Definition and Principles

Biorobotics is an interdisciplinary field that merges principles from robotics, biomedical engineering, and biology to design machines capable of mimicking biological structures and functions, interfacing with living systems, or integrating synthetic and organic components.^[1] This approach draws on biological insights to engineer systems that exhibit lifelike behaviors, such as locomotion or sensory processing, while enabling the study of biological mechanisms through robotic models.^[2] Unlike traditional robotics, which primarily focuses on mechanical and computational efficiency, biorobotics emphasizes the emulation of organic adaptability and interaction. Central to biorobotics are key principles including biomimicry, biohybrid integration, and adaptive control. Biomimicry involves replicating biological designs, such as muscle-like actuation mechanisms or neural-inspired processing, to enhance robotic performance in complex environments. Biohybrid integration combines artificial materials with living tissues, like muscle cells on flexible scaffolds, to create systems with inherent responsiveness and energy efficiency.^[9] Adaptive control relies on feedback loops—rooted in cybernetic foundations—to enable real-time adjustments, allowing robots to respond dynamically to stimuli much like living organisms.^[8] Biorobotics distinguishes itself from pure robotics, which centers on rigid mechanical structures and algorithmic precision without biological emulation, and from bioengineering, which typically applies engineering to biological tissues without emphasizing robotic autonomy or machine-biology interfaces. Instead, it prioritizes the synergistic interaction between artificial and biological elements to achieve enhanced functionality, serving both as a tool for engineering bio-inspired systems and for investigating biological principles through robotic models.^[10] Core concepts in biorobotics include autonomy through bio-inspired mechanisms, such as self-healing materials that repair damage autonomously using embedded chemical reactions, and sensory adaptation that allows systems to adjust perception based on environmental changes.^[11] For instance, soft robotics often draws from the octopus arm's flexible musculature to enable compliant grasping and navigation in unstructured settings, embodying these principles in a conceptual framework for dynamic interaction.^[12] Bionics further supports mimicry techniques by translating anatomical features into engineering solutions.^[13]

Interdisciplinary Aspects

Biorobotics integrates multiple disciplines to create systems that mimic or incorporate biological processes, drawing primarily from robotics for mechanical design and artificial intelligence, biology for anatomical and physiological insights, cybernetics for control theory principles, and materials science for advanced biomaterials such as hydrogels that enable soft, adaptable structures.^[2]^[3] These fields converge to address the complexities of biohybrid systems, where robotic components interface with living tissues to achieve functionality beyond traditional engineering limits.^[14] Key synergies arise from neuroscience, which informs the development of neural interfaces that facilitate sensory-motor integration in robotic systems, and from chemistry, which supports the creation of synthetic tissues through precise molecular assembly for enhanced biocompatibility.^[2]^[15] This interdisciplinary convergence enables the design of adaptive, life-like robots capable of self-healing and responsive behaviors, as seen in biohybrid actuators that combine living cells with synthetic scaffolds.^[16] Biomimicry from biology serves as a primary design driver, inspiring efficient locomotion and sensing mechanisms derived from natural organisms.^[17] Despite these advances, biorobotics faces significant challenges, including the scalability of biological components from cellular to organismal levels, biocompatibility issues that can lead to immune rejection in hybrid systems, and ethical concerns surrounding the integration of living elements, such as animal welfare in research and the moral implications of engineered life forms.^[2] Addressing these requires ongoing collaboration across disciplines to ensure safe and sustainable development.^[14] Biorobotics uniquely bridges applications in medicine through innovations like responsive prosthetics that restore natural movement, in ecology via environmentally adaptive robots for monitoring and remediation, and in artificial intelligence by providing models for complex, emergent behaviors that enhance machine learning algorithms.^[2]^[15] This cross-disciplinary approach fosters tools that not only solve domain-specific problems but also drive broader scientific progress in understanding living systems.^[3]

History

Early Developments

The field of biorobotics traces its conceptual origins to the mid-20th century, emerging from efforts to bridge biological and mechanical systems through principles of control and communication. In 1948, mathematician Norbert Wiener published Cybernetics: Or Control and Communication in the Animal and the Machine, a seminal work that formalized the study of feedback mechanisms applicable to both living organisms and machines, laying the groundwork for bio-inspired robotics by emphasizing regulatory processes shared across biological and engineered systems.^[18] This text drew on wartime research into automated control, highlighting how purposeful behavior in animals could inform machine design. The post-World War II era provided a fertile context for these ideas, as advances in servomechanisms—precision control systems developed for military applications like anti-aircraft guns and radar—revealed parallels to biological regulation, inspiring models that integrated organic feedback with mechanical automation.^[19] Early inspirations focused on analogies between animal nervous systems and machine controls; for instance, neurophysiologist W. Grey Walter constructed the first autonomous mobile robots, known as "tortoises" (Elmer and Elsie), in 1948–1949 using simple vacuum-tube circuits to mimic basic sensory responses and goal-directed movement, such as phototaxis, thereby demonstrating emergent autonomy from minimal components.^[20] A key conceptual contribution from Wiener was the notion of homeostasis in cybernetic systems, which described self-regulating mechanisms to maintain stability amid environmental changes, serving as a precursor to adaptive robotic behaviors that emulate biological resilience.^[18] These foundational ideas later influenced the emergence of bionics as a related extension in the 1960s.

Key Milestones

In the 1960s, the field of biorobotics gained a foundational term with the coining of "bionics" by U.S. Air Force Major Jack E. Steele during a 1960 conference at Wright-Patterson Air Force Base, defining it as the study of systems that mimic biological mechanisms for engineering applications.^[21] This period also saw the emergence of early myoelectric prosthetics, exemplified by Russian scientist Alexander Kobrinski's 1960 development of the first clinically viable myoelectric hand prosthesis, which used electromyographic signals to control movements via transistors, marking a shift toward bioelectrically driven robotic limbs.^[22] The 1970s introduced practical sensory augmentation through the first successful cochlear implants, with Australian surgeon Graeme Clark implanting the world's initial multi-channel device in 1978, restoring partial hearing by electrically stimulating the auditory nerve based on bio-inspired signal processing.^[23] Building on cybernetic principles of feedback control, the 1980s advanced reactive behaviors in robotics via MIT professor Rodney Brooks' 1986 introduction of subsumption architecture, which layered simple, insect-like reactive modules to enable autonomous navigation in dynamic environments without centralized planning.^[24] That decade also witnessed the integration of industrial robots into medicine, as the PUMA 560 arm was employed in 1985 for the first stereotactic neurosurgical biopsy, using computed tomography guidance to precisely position tools, thus pioneering robotic precision in human tissue manipulation.^[25] By the 1990s, biorobotics progressed toward ambulatory prototypes with Honda's development of bio-inspired bipedal walkers, including the P2 humanoid unveiled in 1996, which achieved stable, dynamic walking through zero-moment point control mimicking human balance, laying groundwork for advanced mobility systems. Concurrently, initial biohybrid experiments emerged with tissue-engineered skeletal muscle constructs, such as Richard Strohman's early 1990s work culturing a monolayer of myoblasts on flexible membranes that formed three-dimensional contractile muscle tissue (myooids) upon differentiation, demonstrating potential as biological actuators integrated with synthetic frames.^[26]

Recent Advances

In the 2000s, significant progress in biorobotics included the Argus II bionic eye implant, which underwent its first human clinical trials in 2006, enabling partial vision restoration for patients with retinitis pigmentosa through a retinal prosthesis that stimulates surviving retinal cells.^[27] This development built on bionics principles for sensory augmentation, marking a key step toward implantable neural interfaces. Concurrently, the field saw the emergence of soft robotics inspired by biological tissues, exemplified by Harvard University's Octobot in 2016, the first fully soft, autonomous robot powered by chemical reactions and pneumatic actuation without rigid components.^[28] The 2010s brought innovations in living cellular systems and brain-machine interfaces, with the creation of Xenobots in 2020 by researchers at the University of Vermont and Tufts University, using frog embryonic cells to form programmable, self-assembling micro-robots capable of movement and basic tasks like debris transport.^[29] In 2021, these Xenobots were found capable of self-replication by gathering and assembling loose stem cells into new functional forms.^[4] Advancements in neural interfaces also accelerated, as seen in Neuralink's prototypes from the late 2010s, which developed high-density electrode arrays for bidirectional brain-computer communication, aiming to treat neurological disorders and enhance human cognition.^[30] Entering the 2020s, biohybrid systems gained traction, including Harvard and NTT Research's 2022 collaboration on biohybrid rays incorporating cardiomyocytes for propulsion, designed for potential environmental sensing applications such as environmental monitoring in aquatic settings.^[31] By 2025, MIT engineers introduced a tissue-integrated bionic knee prosthesis that fuses directly with bone and muscle via osseointegration and neural electrodes, restoring natural gait patterns and enabling faster walking and stair navigation for above-knee amputees.^[32] Broader trends in the 2020s reflect a shift toward AI-enhanced biohybrids, where machine learning optimizes designs for improved autonomy and adaptability, as demonstrated in tissue-engineered swimmers.^[33] Ethical frameworks have emerged to address concerns like animal welfare and potential sentience in living components, with calls for interdisciplinary governance to guide responsible development.^[34] Applications are expanding into targeted drug delivery, using biohybrid microrobots to navigate biological barriers with precision, and disaster response, where insect-inspired hybrids aid in search-and-rescue by detecting survivors in rubble.^[35]^[36]

Cybernetics

Foundations

Cybernetics serves as the theoretical backbone of biorobotics, providing a framework for understanding control and communication processes that bridge biological and mechanical systems. Coined by Norbert Wiener in 1948, cybernetics is defined as the study of control and communication in the animal and the machine, emphasizing how information flows enable self-regulation and adaptation in complex entities.^[18] This discipline integrates principles from engineering, biology, and mathematics to model systems that maintain stability amid environmental changes. At its core, cybernetics revolves around fundamental concepts such as circular causality, where causes and effects form recursive loops rather than linear sequences, allowing systems to evolve through ongoing interactions. Feedback loops are central to this framework, with negative feedback promoting stability by counteracting deviations to achieve homeostasis, as seen in biological regulatory processes like temperature control in organisms. Additionally, information theory underpins cybernetic analysis of biological systems, quantifying how uncertainty and entropy are managed through communication channels to support decision-making and adaptation.^[37]^[38]^[39] In biorobotics, these cybernetic principles enable the design of robots that process sensory data akin to neural networks in living organisms, facilitating real-time environmental interaction and self-correction. Key structures, such as observer-controller architectures, allow robots to estimate internal states from external inputs and adjust outputs accordingly, mirroring biological sensory-motor loops. A basic negative feedback model defines the error as the difference between the reference input r and the measured output y, so e = r - y. The controller then computes the control signal as u = K e, where K is the gain, to adjust the system input and drive the output toward the reference, enabling self-correction in robotic control loops to minimize deviations and enhance performance.^[40]

Feedback Mechanisms

Feedback mechanisms in biorobotics draw from cybernetic principles, where systems self-regulate through loops that compare outputs to desired states, as pioneered by Norbert Wiener in his foundational work on control and communication in animals and machines. In biorobotic systems, these mechanisms enable adaptive responses to environmental perturbations, integrating biological and artificial components for precise operation. Negative feedback predominates for achieving stability, counteracting deviations to maintain equilibrium, akin to a thermostat regulating temperature in robotic limbs to mimic muscle control. For instance, in biohybrid robots, negative feedback loops use sensor inputs from biological tissues to adjust actuator signals, ensuring consistent locomotion despite external disturbances.^[36] Positive feedback, conversely, amplifies signals for rapid escalation, such as in swarming behaviors where quorum sensing in microbial components triggers collective amplification of motion patterns.^[36] These mechanisms parallel biological processes like homeostasis, where negative feedback sustains internal balance (e.g., osmo-adaptation in yeast via MAPK pathways), and reflexes, involving sensor-actuator loops for quick responses in soft robots inspired by neural circuits.^[41] In biorobotics, implementation relies on sensor fusion, combining tactile data from force-sensing resistors with visual inputs from neuromorphic cameras to inform real-time decisions, processed via adaptive algorithms like spiking neural networks that modulate central pattern generators.^[42] Challenges arise from noise in biological signals, such as fluctuations in cell-derived outputs due to environmental interference, requiring filtering techniques like Gaussian smoothing for reliable detection.^[43] Latency in hybrid systems, stemming from signal propagation delays in living tissues, further complicates synchronization, often mitigated through multiscale modeling but limiting responsiveness in unstructured environments.^[36] A core equation for simple closed-loop proportional control is u(t) = K(e(t)), where u(t) is the control signal, e(t) the error (difference between desired and actual state), and K the gain; tuning K balances speed and stability—low values yield sluggish responses, while high values risk oscillations, as seen in biological models like bacterial chemotaxis where gains are optimized for robust adaptation.^[41]

Applications

Cybernetic principles in biorobotics enable advanced control systems that integrate feedback loops to enhance robotic adaptability and performance in dynamic environments. These applications leverage real-time sensory data processing and behavioral hierarchies to achieve robust decision-making without relying on centralized computation, drawing from foundational cybernetic concepts like self-regulation and homeostasis.^[44] In adaptive robotics, cybernetic feedback facilitates autonomous drones that mimic bird flocking behaviors for collision avoidance. By implementing decentralized control algorithms inspired by natural swarms, drones maintain cohesion and alignment while dynamically adjusting velocities to evade obstacles, as demonstrated in evolutionary optimization models that achieve safe navigation in confined spaces.^[45] Such systems use local interaction rules—separation, alignment, and cohesion—processed through neural network-based feedback to ensure collective stability during missions like search-and-rescue operations.^[46] Medical devices represent a key application, where cybernetic prosthetics incorporate real-time feedback for gait correction in exoskeletons. These devices employ adaptive control strategies that monitor user biomechanics and adjust torque assistance to symmetrize limb movements, improving walking efficiency for individuals with mobility impairments.^[47] For instance, assist-as-needed controllers optimize human-exoskeleton interaction by minimizing unnecessary support, thereby promoting natural recovery and reducing metabolic cost during locomotion.^[48] Swarm systems utilize cybernetic feedback for collective decision-making in bio-inspired robot groups, enabling emergent behaviors through distributed information sharing. In these setups, individual robots exchange local signals to resolve conflicts and converge on optimal paths, as seen in probabilistic guidance algorithms that distribute tasks across large-scale swarms for environmental monitoring.^[49] This approach enhances scalability and fault tolerance, with feedback loops amplifying successful strategies to achieve group-level intelligence.^[50] Notable examples include the subsumption architecture adapted for NASA's planetary rovers in the 1990s, which layered reactive behaviors to prioritize immediate survival tasks like obstacle avoidance over long-term planning, allowing autonomous navigation on uneven terrain.^[51] Recent advances as of 2024 include cybernetic frameworks for coordinating biohybrid swarms using decentralized feedback, improving scalability in environmental monitoring tasks.^[52] In modern contexts, cybernetic control in rehabilitation robots supports stroke recovery by providing adaptive assistance during upper-limb exercises, where feedback from motor function scores motivates patients and refines therapy intensity for improved outcomes.^[53]

Bionics

History and Concepts

The term "bionics" was coined in 1958 by Major Jack E. Steele, a researcher at the U.S. Air Force's Wright-Patterson Air Force Base, during early efforts to apply biological principles to engineering challenges in aerospace. ^[54] The concept gained formal recognition in 1960 at a symposium hosted by the Air Force, where Steele defined bionics as the study of systems that mimic living organisms to solve technical problems. ^[55] Its roots trace to mid-1950s U.S. Air Force initiatives in bioastronautics, which explored biological adaptations—such as bird flight mechanics—for improving aircraft performance and human-machine interfaces. ^[56] At its core, bionics emphasizes functional mimicry, where engineers replicate the structure-function relationships observed in biological systems to enhance artificial designs. ^[57] For instance, the nanoscale setae on gecko feet, which enable adhesion through van der Waals forces, have inspired dry adhesive grippers for robotics that achieve strong, residue-free attachment without mechanical clamps. ^[58] This approach prioritizes translating biological efficiency into engineered solutions, focusing on how natural forms achieve performance under constraints like limited resources or harsh environments. Key principles of bionics include hierarchical design, which mirrors the multi-scale organization in nature—from macroscopic shapes to microscopic features—to optimize strength and adaptability; energy efficiency, drawing from biological processes that minimize waste through streamlined mechanisms; and modularity, allowing interchangeable components akin to modular tissues in organisms for scalable and repairable systems. ^[59] ^[60] These principles guide the passive imitation of biological forms, distinguishing bionics from cybernetics, which addresses active feedback and control in dynamic systems. ^[61]

Prosthetic Devices

Bionic prosthetic devices in biorobotics represent advanced mobility aids designed to replace lost limbs, particularly upper and lower extremities, by combining robotic actuation with biological mimicry to facilitate natural locomotion. These systems prioritize motor function restoration, enabling users to perform daily activities with greater autonomy. Unlike traditional passive prosthetics, bionic variants incorporate powered mechanisms and sensors to adapt to user intent and environmental demands, fundamentally enhancing ambulatory capabilities for individuals with amputations or mobility impairments. Key types of bionic prosthetics include myoelectric upper-limb devices and powered lower-limb exoskeletons. Myoelectric arms, such as Ottobock's Michelangelo hand introduced in the 2010s, detect electromyographic (EMG) signals from residual forearm muscles to control multiple grip patterns, including palmar and lateral grasps, through an active wrist and articulating fingers. This allows for intuitive operation without mechanical switches, restoring dexterity for tasks like object manipulation. For lower limbs, the ReWalk exoskeleton, cleared by the FDA in 2014 for personal use, employs motorized hip and knee joints activated by body-weight sensors and trunk motion, enabling paraplegic users to stand, walk, and navigate indoors and outdoors while promoting an upright posture. Recent advancements have focused on seamless integration and enhanced functionality. In 2025, MIT engineers developed a tissue-integrated bionic knee prosthesis that anchors directly to the femur and residual muscles via osseointegration and implanted electrodes, allowing for faster walking speeds, improved stair ascent, and better obstacle avoidance compared to conventional sockets. This design restores biomimetic gait by transmitting neural signals bidirectionally, reducing energy costs associated with prosthetic use. Complementary features, such as vibrotactile cues delivered through embedded stimulators, provide proprioceptive feedback to refine movement precision and prevent stumbles during ambulation. Material innovations underpin the durability and biomimicry of these devices. Carbon fiber composites form lightweight, high-strength frames that emulate bone rigidity while minimizing user fatigue, as seen in modern transfemoral prosthetics. Shape-memory alloys, which deform under heat or stress and recover their original form, replicate muscle actuation in joints, enabling adaptive responses to varying loads during gait cycles. The adoption of bionic prosthetics has demonstrably elevated quality of life, with users reporting increased independence, reduced pain, and higher self-esteem through restored mobility. Clinical studies highlight gait efficiency improvements, including 26-30% gains in center-of-mass push-off work and metabolic energy savings during walking, particularly with powered systems like variable-stiffness ankles or exoskeletons. These outcomes draw from bionic principles that prioritize anatomical fidelity for intuitive control and long-term adherence.

Sensory Augmentation

Sensory augmentation in biorobotics focuses on developing implantable or wearable devices that restore or enhance human sensory capabilities through bioengineered interfaces, particularly for hearing, vision, and touch, by mimicking natural neural pathways. These systems typically employ electrodes to deliver electrical stimuli directly to sensory nerves or brain regions, bypassing damaged peripheral structures to elicit perceptual responses. Such technologies have evolved from early experimental implants to clinically viable prosthetics, improving quality of life for individuals with sensory deficits.^[62] In auditory restoration, bone-anchored hearing aids (BAHA) represent a foundational advancement, first implanted in 1977 by Anders Tjellström and Per-Ingvar Brånemark using titanium fixtures to transmit sound vibrations directly to the skull, avoiding issues with traditional air-conduction aids in conductive hearing loss cases.^[63] This percutaneous approach, which became commercially available in 1987, enables clearer sound perception by coupling a vibrator to the bone without skin interference. Complementing BAHA, multi-channel cochlear implants, pioneered by Graeme Clark with the first successful implantation in 1978, electrically stimulate the auditory nerve to restore hearing in sensorineural loss patients.^[23] By the early 2020s, over one million such devices had been implanted worldwide, with ongoing refinements enhancing speech recognition and music perception.^[64] For visual restoration, the Argus II retinal prosthesis, approved by the FDA in 2013, utilizes a 60-electrode epiretinal array to stimulate surviving retinal ganglion cells in patients with retinitis pigmentosa, enabling perception of light patterns and basic object outlines through a camera-mounted external processor.^[65] Users can discern large shapes and motion, achieving functional vision equivalent to 20/1260 acuity in clinical trials. Emerging retinal prosthetics in 2025 incorporate artificial intelligence for signal optimization, such as adaptive pattern recognition algorithms that enhance image preprocessing and electrode stimulation mapping to improve contrast sensitivity and object detection in conditions like age-related macular degeneration.^[66] These AI-driven systems, tested in subretinal photovoltaic implants, allow patients to read letters and perform daily tasks like navigation.^[67] Tactile sensory augmentation employs artificial electronic skins (e-skins) integrated into prosthetics to provide touch feedback, often using piezoelectric sensors that generate voltage in response to mechanical deformation for detecting pressure, texture, and vibration. These flexible, multi-layered sensors, inspired by human mechanoreceptors, enable real-time haptic perception by converting skin deformations into electrical signals for neural interfaces. For instance, multiplexed piezoelectric e-skins fabricated with nanomaterials allow precise spatial resolution, distinguishing force magnitudes and contact modes to restore naturalistic touch in upper-limb prosthetics.^[68] At the core of these devices, neural stimulation occurs via microelectrodes that deliver patterned electrical pulses to targeted nerve fibers or cortical areas, with onboard signal processing units employing algorithms for feature extraction and pattern recognition to translate sensory inputs into biologically plausible outputs. This involves filtering raw signals from external sensors, applying machine learning models to identify relevant patterns like edges in visual data or frequencies in auditory inputs, and modulating stimulation parameters to match neural firing rates for perceptual fidelity. Such mechanisms ensure that augmented sensations feel intuitive, as demonstrated in optimization frameworks that tailor encoding strategies to individual neural responses.^[69] In full-limb prosthetics, these sensory systems integrate briefly with motor controls to provide closed-loop feedback, enhancing overall embodiment.

Surgical Applications

Biorobotics has significantly advanced surgical applications by integrating bio-inspired designs to enhance precision, minimize invasiveness, and improve procedural outcomes in minimally invasive procedures. These systems draw from biological mechanisms to enable robots to navigate complex anatomical environments, perform delicate manipulations, and provide surgeons with enhanced control, thereby reducing human error and patient trauma. Key developments include robotic platforms that emulate natural locomotion and sensory capabilities, facilitating interventions in hard-to-reach areas such as the gastrointestinal tract and internal organs.^[70] Endoscopic robots represent a prominent example of bio-inspired surgical tools, particularly those designed for gastrointestinal (GI) tract exploration and intervention. Pill-sized or capsule endoscopes with bio-inspired propulsion mechanisms, such as snake-like continuum robots, allow for autonomous or semi-autonomous navigation through the tortuous paths of the intestines, mimicking the undulating motion of serpentine locomotion observed in nature. Developed prominently in the 2010s, these systems feature modular segments with multiple degrees of freedom, enabling them to traverse narrow lumens while incorporating cameras and tools for biopsy or polyp removal; for instance, the i² Snake platform, introduced around 2018, uses cable-driven actuation for flexible endoscopic surgery. Such designs have improved diagnostic accuracy in lower GI procedures by reducing the need for sedation and enabling real-time imaging without full-body incisions.^[71]^[72]^[73] In broader robotic surgery, systems like the da Vinci Surgical System, first approved by the FDA in 2000, exemplify bionic integration by providing surgeons with teleoperated arms that offer seven degrees of freedom per end effector, surpassing human wrist dexterity and filtering out physiological tremors for steadier incisions. As of 2024, da Vinci platforms have facilitated nearly 17 million procedures worldwide, predominantly in urology, gynecology, and general surgery, with annual procedure volumes exceeding 2.5 million and projected to grow further in 2025.^[74]^[75] Bio-inspired features further enhance these systems, such as grippers modeled on octopus suckers that enable adaptive suction and gentle tissue handling; a 2024 biomimetic octopus suction cup, for example, incorporates self-sensing for precise cardiac interventions, providing haptic feedback to mimic tactile perception during grasping. Recent 2025 advances in micro-robots, including swarms for targeted tumor therapy, allow for localized ablation or drug delivery to neoplasms, navigating vascular or tissue pathways with propulsion inspired by bacterial flagella or spermatozoa.^[76] The benefits of these biorobotic surgical tools include substantially reduced invasiveness, with smaller incisions leading to less postoperative pain, lower infection risks, and shorter hospital stays compared to traditional open surgery. Precision is markedly improved, achieving error rates under 1% in tasks like suturing or tissue dissection, thanks to enhanced visualization and tremor elimination; studies show up to a 93% reduction in operative errors with advanced 3D imaging integration. These attributes not only accelerate patient recovery but also expand the feasibility of complex procedures in minimally invasive contexts.^[77]^[78]^[79]

Biohybrid Robots

Design Principles

Biohybrid robots are engineered through hybrid architectures that integrate synthetic scaffolds with living tissues to enable actuation and functionality inspired by natural systems. These scaffolds typically consist of biocompatible polymers, such as polydimethylsiloxane (PDMS) or polylactic acid, which provide structural support while allowing the attachment and growth of living tissues for muscle-like contraction. This combination leverages the mechanical stability of synthetic frames with the dynamic responsiveness of biological components, facilitating designs that mimic organic movement without relying solely on rigid robotics.^[80]^[81] Key design principles emphasize biocompatibility to prevent immune rejection and ensure seamless integration between synthetic and living elements, often achieved through materials like hydrogels (e.g., gelatin methacrylate) that mimic the extracellular matrix. Scalability is another core principle, enabling construction from microscale devices using cellular layers to macroscale systems via 3D bioprinting techniques, addressing challenges like tissue shrinkage during maturation. Power derivation from adenosine triphosphate (ATP) in living cells provides efficient, self-sustaining energy conversion with efficiencies exceeding 50%, surpassing many traditional actuators in metabolic adaptability.^[80]^[81] Control mechanisms in biohybrid designs primarily involve electrical stimulation to mimic neural signals, promoting tissue alignment and precise contractions, such as generating forces up to 2.5 mN in stimulated constructs. Incorporation of soft materials, including compliant polymers and hydrogels, enhances flexibility and biomimicry, allowing deformation akin to natural tissues for applications requiring adaptability. These approaches draw brief inspiration from bionics, adapting biological actuation principles to robotic frameworks.^[80]^[81] Despite these advances, significant challenges persist in sustaining living components, particularly nutrient delivery limited by diffusion in thicker tissues, necessitating perfusion systems or vascularization strategies. Waste removal similarly demands engineered environments to maintain cellular viability over extended periods, as accumulation can impair function and longevity in biohybrid systems. Ethical and regulatory considerations are also emerging, with researchers calling for guidelines to address concerns over the development of "living robots" and their societal impacts as of 2024.^[80]^[81]^[82]

Biological Components

Biological components in biohybrid robots encompass living tissues and cells that impart essential functionalities such as actuation, signaling, and responsiveness, distinguishing these systems from purely synthetic alternatives. These elements are carefully selected for their biocompatibility and ability to interface with robotic frameworks, enabling lifelike performance in dynamic environments.^[80] Skeletal muscle tissues serve as primary actuators for contraction in biohybrid robots, leveraging their natural force-generation capabilities upon electrical or optical stimulation. Rat-derived cardiomyocytes, in particular, are widely utilized due to their spontaneous beating and robust contractile properties, which mimic cardiac muscle dynamics and drive robotic locomotion efficiently.^[83] Neurons, often sourced from mammalian models, provide signaling pathways that coordinate muscle activation through neuromuscular junctions, allowing precise control over movement and response to stimuli.^[84] Cell sources for these components frequently include stem cells, which facilitate self-assembly into functional structures. Frog embryonic stem cells, for instance, have been assembled into multicellular aggregates known as xenobots that exhibit collective motility and environmental sensing without external programming. Human-derived stem cells or progenitor cells similarly enable the formation of self-organizing tissues, supporting scalable biohybrid construction. To maintain structural integrity and mimic the extracellular matrix, these cells are embedded in hydrogel matrices such as gelatin methacryloyl (GelMA) or fibrin, which provide mechanical support and promote cell viability during culture.^[80] Integration of biological components requires strategies to ensure long-term functionality, particularly through vascularization to deliver oxygen and nutrients to embedded tissues. This process involves engineering perfusable vessel networks within the constructs to prevent hypoxia and support thicker, more complex tissue layers.^[85] As of 2025, advances in 3D bioprinting have enabled the precise deposition of cellular and vascular elements into organ-like structures, enhancing scalability and mimicking native tissue architectures for biohybrid applications.^[86] These biological elements confer unique properties, including self-repair through endogenous regeneration processes that restore functionality after damage, and adaptability via biochemical responses to external cues. Such attributes provide superior flexibility compared to rigid actuators, allowing biohybrid systems to navigate irregular terrains and conform to varied shapes with greater efficiency.^[81] Biological components are typically anchored to synthetic scaffolds that facilitate secure attachment and mechanical coupling.^[36]

Notable Examples

One prominent example of a biohybrid robot is the xenobot, developed in 2020 by researchers at Tufts University and the University of Vermont. These millimeter-scale organisms are assembled from dissociated frog (Xenopus laevis) embryonic cells, primarily skin cells shaped into structures and cardiac cells providing motility through collective beating. Xenobots demonstrate coordinated locomotion, such as swimming in aqueous environments, and can aggregate to perform collective tasks like pushing debris, highlighting their potential for applications in targeted drug delivery within biological systems. The biohybrid ray, developed in 2025 by a collaboration between Harvard University and NTT Research, exemplifies progress in soft biohybrid locomotion. Constructed with rat cardiomyocytes cultured on a flexible elastomer substrate mimicking a ray's fin structure, this millimeter-scale device (wingspan approximately 10 mm) propels itself through undulating motions driven by synchronized heart cell contractions. Capable of self-propelled swimming at speeds up to several body lengths per second, it is designed for potential use in environmental monitoring, such as navigating fluid environments to sense pollutants.^[33] A 2024 biohybrid robot incorporating human-derived cells was created by researchers at Harvard Medical School, featuring human induced pluripotent stem cell-derived neurons and skeletal muscle cells integrated on a synthetic skeleton with fins. This device uses neural-muscle interfaces controlled by a wireless electronic circuit that processes inputs and directs contractions via magnetic stimulation, enabling swimming motions such as flapping fins separately or together to navigate corners and distances multiple times its body size. The robot's ability to exhibit adaptive movement through neural-muscle synergy underscores its promise for studying human neuromuscular disorders and developing therapeutic platforms.^[87]

Synthetic Biology in Biorobotics

Genetic Engineering Techniques

Genetic engineering techniques play a pivotal role in modifying biological components for biorobotics by enabling the precise insertion of genetic material into cells to confer desired functions, such as enhanced responsiveness or marker expression.^[88] The plasmid method involves inserting recombinant DNA into small, circular DNA molecules known as plasmids, which serve as bacterial vectors to achieve stable gene expression in host cells.^[89] This approach is particularly effective for engineering bacterial cells used in biohybrid systems, where plasmids facilitate the introduction of genes for motility or sensing capabilities.00508-9) For instance, plasmids have been employed to express fluorescent markers like green fluorescent protein (GFP) in bacterial components, allowing real-time visualization and tracking in robotic assemblies.^[90] Viral vector methods utilize modified viruses, such as adeno-associated virus (AAV) vectors, to deliver genetic material with high specificity to target tissues like muscle cells.^[91] AAV vectors are favored for their low immunogenicity and ability to transduce non-dividing cells, making them suitable for precise targeting in mammalian muscle tissues integrated into biohybrid robots.^[92] In practice, AAV delivery has been used to introduce optogenetic constructs into skeletal muscle cells, enabling light-triggered contraction for actuation in robotic prototypes.^[93] The biolistic method, also known as gene gun delivery, propels DNA-coated microprojectiles at high velocity into cells, providing a non-viral alternative for transformation. This technique is advantageous for penetrating tough cell walls or tissues without relying on cellular uptake mechanisms, and it has been applied to animal cells for transient gene expression.^[94] In biorobotics contexts, biolistics enables the direct introduction of genetic payloads into multicellular aggregates, supporting rapid prototyping of engineered tissues.^[95] These techniques enhance cell actuation by incorporating genes that confer responsiveness to external stimuli, such as light or magnetic fields, thereby improving the performance of biological actuators in robotic systems.^[80] A notable advancement is the 2025 CRISPR.BOT platform, an autonomous robotic system built from LEGO Mindstorms components that automates CRISPR-Cas9 editing workflows, achieving up to 100% purity in single-cell subcloning for GFP and gRNA expression.^[96] Such tools streamline the preparation of genetically modified cells for biorobotic applications. These methods are essential for developing biological components in biohybrid robots, where modified cells provide adaptive and energy-efficient functionality.^[36]

Cellular Circuits

Synthetic genetic circuits in biorobotics enable precise control over cellular functions, such as actuation and sensing, by engineering gene regulatory networks that process environmental signals and drive targeted responses within living cells integrated into robotic systems. These circuits mimic electronic analogs, allowing cells to perform computations that contribute to biohybrid functionality, like coordinated contractions or conditional behaviors.^[97] Key circuit types include genetic oscillators and logic gates. Genetic oscillators, such as the repressilator, generate periodic gene expression patterns that can induce rhythmic cellular contractions, providing autonomous timing for actuators in biohybrid devices. The repressilator consists of three repressor genes in a cyclic feedback loop, where each protein inhibits the next, leading to sustained oscillations with periods of approximately 40 minutes in bacterial cells. Logic gates, including AND and OR configurations, enable signal processing by integrating multiple inputs to activate outputs only under specific conditions, such as combined chemical cues for selective cellular responses in robotic sensing modules.^[97]^[98] Circuit design relies on promoters and repressors to emulate electronic components, creating networks where transcription factors regulate gene expression dynamically. For instance, toggle switches employ mutual repression between two promoters to establish bistable states, allowing cells to maintain one of two expression profiles until an external signal flips the switch, useful for memory-like functions in cellular controllers. These designs are grounded in the biological basis of robust computation in model organisms like Escherichia coli for bacterial circuits or yeast for eukaryotic implementations, leveraging their well-characterized genetics for reliable operation. A foundational model for simple repression in such circuits is given by the differential equation

\frac{dX}{dt} = \beta \frac{1}{1 + (R/K)^n} - \gamma X,

where X represents the concentration of the repressed protein, R is the repressor concentration, \beta is the maximum production rate, \gamma is the degradation rate, K is the dissociation constant, and n is the Hill coefficient capturing cooperative binding; this equation describes how repressor binding to the promoter reduces protein synthesis, forming the basis for oscillatory and switching behaviors.^[97] Advances in the 2020s have focused on multi-input circuits that enable adaptive responses in engineered tissues, integrating diverse signals like chemicals or light to fine-tune cellular outputs for more complex biorobotic applications. For example, combinatorial promoter systems allow circuits to process multiple environmental inputs simultaneously, achieving robust logic operations in mammalian cells that support tissue-level coordination without external wiring. These developments build on engineering techniques for circuit assembly, enhancing scalability for biohybrid systems.^[98]^[99]^[100]

Integration with Robotics

In biohybrid systems, synthetic biology components interface with robotic frameworks through specialized mechanisms that enable bidirectional communication and sustained functionality. Electrodes, often fabricated from materials like carbon nanotubes or gold, deliver precise electrical stimuli to engineered cells, triggering contractions in muscle tissues integrated into robotic actuators.^[80] Microfluidic channels, mimicking vascular networks, facilitate nutrient delivery and waste removal to maintain cellular viability within hybrid structures, preventing tissue degradation during prolonged operation.^[80] Control strategies in these integrations rely on advanced oversight to synchronize biological responses with robotic objectives. Artificial intelligence, particularly machine learning algorithms, provides closed-loop regulation by processing real-time feedback from cellular activity, such as strain or electrophysiological signals, to adjust stimulation parameters dynamically.^[101] For instance, in xenobot swarms—aggregates of engineered frog cells forming autonomous collectives—computational models informed by AI predict and elicit coordinated behaviors like debris transport, enhancing task efficiency in dynamic environments.^[102] These approaches leverage underlying cellular circuits to provide logical decision-making at the biological level, ensuring seamless fusion with synthetic control layers. Notable examples demonstrate practical implementations of such integrations. In 2025 developments, optogenetically controlled neuromuscular junction biohybrid robots incorporate mouse motor neurons and skeletal muscles within 3D-printed scaffolds, enabling wireless light-based actuation for crawling locomotion.^[93] Similarly, machine learning-optimized tissue-engineered ray robots use fin-like cardiac muscle actuators to achieve undulatory swimming, with AI directing morphological adaptations for enhanced swimming performance.^[33] The primary benefits of these integrations include superior adaptability and endurance compared to purely synthetic systems. Hybrid actuators exhibit energy efficiency exceeding 50%, attributed to the self-regenerative properties of biological tissues, allowing sustained operation without frequent recharging.^[80] This results in enhanced performance in unpredictable settings, where biohybrid robots demonstrate robustness to environmental stressors, such as mechanical fatigue, far beyond traditional robotic limits.^[101]

Animal-Robot Interactions

Bio-Hybrid Organisms

Bio-hybrid organisms represent a subset of biorobotics where living animals, typically insects, are augmented with robotic implants to extend or modify their natural abilities, creating cyborg systems that blend biological locomotion and sensing with engineered control mechanisms.^[103] These augmentations often involve interfacing electronic devices directly with the animal's nervous system to enable remote operation, leveraging the insect's inherent agility and endurance for tasks in challenging environments.^[36] Pioneering efforts in this area emerged in the early 2000s, focusing on small-scale animals due to their compatibility with miniaturized hardware and low power requirements.^[104] These bio-hybrid approaches have raised ethical concerns regarding animal welfare and the moral implications of creating cyborg organisms, prompting discussions on guidelines for such research.^[105] A key example is the cyborg cockroach, developed through the U.S. Defense Advanced Research Projects Agency (DARPA) Hybrid Insect Micro-Electro-Mechanical Systems (HI-MEMS) program initiated around 2006, which implanted neural electrodes into cockroaches to allow remote control of their steering and movement via electrical stimulation of the brain or leg muscles.^[106] In these systems, fine-wire electrodes are surgically inserted into the insect's central nervous system during or shortly after the pupal stage to ensure integration without severely impairing natural function, enabling directed navigation over distances of up to several meters with response times under one second.^[104] Similar augmentations have been applied to beetles and moths, where implants target flight muscles to achieve controlled airborne maneuvers, demonstrating the versatility of neural interfacing across insect species.^[107] The design of these implants emphasizes miniaturization and energy efficiency to avoid overloading the host organism. Miniature backpacks, weighing as little as 0.5 grams, typically incorporate a microcontroller for signal processing, wireless transceivers for command reception (e.g., via Bluetooth or WiFi), and power sources such as thin-film solar cells that harvest ambient light to sustain operations for hours without recharging.^[108] Biocompatibility is prioritized through the use of soft, flexible polymers like polydimethylsiloxane (PDMS) for encapsulation, which reduces tissue irritation and mechanical stress on the insect's exoskeleton during movement.^[109] Surgical attachment involves biocompatible adhesives or lightweight harnesses to secure the device to the dorsal surface, ensuring the implant does not hinder the animal's gait or lifespan, which can extend to weeks post-implantation in optimized designs.^[110] These bio-hybrid organisms gain enhanced sensing capabilities through integrated robotic components, such as compact cameras mounted on the backpack, which provide visual data for real-time environmental assessment in confined or obstructed spaces. For instance, the CameraRoach system equips Madagascar hissing cockroaches with a 160x120 pixel wireless camera and WiFi module, streaming low-resolution video at up to 1 frame per second to enable operators to guide the insect through narrow passages like rubble or pipes, where traditional robots struggle due to size constraints.^[111] This augmentation complements the insect's innate olfactory and tactile senses, allowing hybrid navigation that combines biological robustness with artificial perception for improved traversability in unstructured terrains.^[112]

Mixed Societies

Mixed societies in biorobotics refer to the integration of robots into groups of animals to influence or observe collective behaviors, such as aggregation or schooling, by embedding robotic agents that mimic social cues of their biological counterparts. This approach leverages the self-organizing dynamics of animal groups, allowing robots to participate as peers without dominating the interaction, thereby enabling subtle modulation of group-level decisions.^[113] For instance, robotic fish designed with biomimetic features have been introduced into shoals of live fish to study synchronized swimming patterns.^[114] A notable example is the LEURRE project (2005–2007), which demonstrated the formation of mixed societies between microrobots and cockroaches (Blattella germanica) to guide collective choices, such as shelter selection during aggregation. In these experiments, up to four InsBot microrobots were integrated into groups of 10–30 cockroaches, successfully influencing 60–80% of the group's decisions toward preferred shelters by adapting robot behaviors to local animal stimuli.^[115] Similarly, in aquatic settings, a 2019 study integrated a robotic fish into shoals of zebrafish (Danio rerio), where the robot acted as a leader in approximately 70% of trials, promoting cohesive group motion akin to natural schooling.^[113] Integration in mixed societies relies on mechanisms that replicate animal communication, such as visual cues for fish or tactile and chemical signals for insects. For zebrafish, a biomimetic lure with passive tail undulation provided visual similarity, facilitating acceptance without eliciting avoidance.^[113] In the cockroach experiments, microrobots used infrared sensors to detect nearby animals and emitted synthetic pheromones or physical contacts to mimic conspecific interactions, enabling social recognition. Key challenges include synchronizing robot movements with animal speeds to maintain group cohesion and preventing behavioral disruption that could fragment the society. In fish trials, mismatched interaction models increased average angular distances between members by up to 30° compared to all-biological groups, reducing synchronization.^[113] For cockroaches, hardware constraints like limited sensor range and imprecise chemical signal synthesis risked detection as non-conspecifics, potentially leading to exclusion.

Research Applications

Animal-robot interactions have enabled behavioral studies that probe collective decision-making processes in social animals. For instance, researchers integrated a biomimetic robot into shoals of zebrafish (Danio rerio) to influence their turning decisions during group navigation, demonstrating how robotic cues can modulate collective polarization and leadership emergence in fish schools.^[113] Similarly, robotic manipulators have been used to deliver precise tactile stimuli to worker ants (Temnothorax albipennis), revealing density-dependent responses that inform models of foraging and nest-site selection decisions in ant colonies.^[116] These interactions provide ecological insights by simulating predator-prey dynamics, allowing controlled tests of biodiversity models. In experiments with live prey and robotic predators, information-theoretic frameworks quantified mutual information flow between agents, validating predictions of population stability and coexistence under varying predation pressures.^[117] Such setups reveal how localized interactions contribute to broader ecosystem resilience, without altering natural habitats. Recent advances in Animal-Robot Interaction Systems (ARIS), highlighted in a 2024 special issue, have uncovered emergent cooperation in mixed groups, where robots facilitate adaptive task allocation among animals like ants during cooperative excavation.^[118] In 2025, researchers used robotic fish to observe brain activity in zebrafish larvae, providing insights into neural mechanisms of behavior during interactions.^[119] These findings extend to conservation robotics, where animal-inspired robots monitor endangered species and mitigate human-wildlife conflicts, enhancing habitat protection strategies.^[120] Overall, these applications have improved computational models of self-organization, incorporating quantifiable metrics such as group cohesion indices—defined as the average nearest-neighbor distance within collectives—to predict phase transitions from disordered to aligned motion.^[113] Mixed societies enabled by robots allow precise manipulation of variables, yielding more robust simulations of collective dynamics than traditional observational methods alone.

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Genetic circuits in synthetic biology: broadening the toolbox of ...
Large-scale design of robust genetic circuits with multiple inputs and outputs for mammalian cells. Nat. Biotechnol. 35, 453–462. doi:10.1038/nbt.3805.Missing: 2020s | Show results with:2020s
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Synthetic Gene Circuits Enable Sensing in Engineered Living ...
Aug 22, 2025 · Here, we highlight how rationally designed genetic circuits enable living materials to sense and respond to diverse inputs—including ...
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Taking control: Steering the future of biohybrid robots - Science
Sep 25, 2024 · The use of biological actuators in soft robotics, termed biohybrid robotics, is a rapidly growing field harnessing the power of biological ...
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A cellular platform for the development of synthetic living machines
We report here a method for generation of in vitro biological robots from frog (Xenopus laevis) cells. These xenobots exhibit coordinated locomotion via cilia ...
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Biohybrid robotics: From the nanoscale to the macroscale - Mestre
Feb 2, 2021 · Skeletal muscle is currently the most used tissue for biohybrid engineering due to its controllability and adaptability (Ricotti et al., 2017).
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Darpa hatches plan for insect cyborgs to fly reconnaissance
Cyborg insects with embedded microelectromechanical systems (MEMS) will run remotely controlled reconnaissance missions for the military, if its '”HI-MEMS” ...
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[PDF] MEMS BASED BIOELECTRONIC NEUROMUSCULAR ...
This paper reports the first direct control of insect flight by manipulating the wing motion via microprobes and electronics introduced through the Early ...
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Backpack Turns a Beetle Into a Remote-Controlled Cyborg | WIRED
Mar 16, 2015 · Researchers can electrically stimulate tiny muscles below its wings, creating a living mini-copter that they can steer with amazing precision.
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Integration of body-mounted ultrasoft organic solar cell on cyborg ...
Sep 5, 2022 · A biofuel cell that generates power from an insect's body is a promising energy-harvesting device. To date, 333 μW is the highest output power ...
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Cyborg insect repeatable self-righting locomotion assistance using ...
May 27, 2024 · The present study introduces a bio-inspired 3D-printed artificial limb that serves to facilitate the maneuverability of cyborg insects amidst unpredictable ...
[104]
Biohybrid Behavior-Based Navigation with Obstacle Avoidance for ...
Feb 11, 2025 · Autonomous navigation incorporating feedback from a Kinect camera had been applied to control the cyborg insect to follow a predetermined path ...
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[PDF] CameraRoach: A WiFi- and Camera-Enabled Cyborg Cockroach for ...
We designed and implemented a backpack containing a WiFi equipped miniature camera and neuro-stimulation hardware that can be mounted on a cockroach. The back-.
[106]
Smart insect-computer hybrid robots empowered with enhanced ...
Jun 24, 2024 · This paper proposes a navigation algorithm with an integrated obstacle avoidance module using a monocular camera for the insect-computer hybrid robot.Missing: labs biohybrid
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Bidirectional interactions facilitate the integration of a robot into a ...
Aug 20, 2019 · These findings provide insight on the ability to form mixed societies of animals and robots and yield promising results on the degree to which ...
[108]
Portraits of self-organization in fish schools interacting with robots
In this paper, we propose an enabling computational and theoretical framework for the analysis of experimental instances of collective behavior in response ...
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Precise tactile stimulation of worker ants by a robotic manipulator ...
Nov 29, 2023 · Precise tactile stimulation of worker ants by a robotic manipulator reveals that individual responses are density- and context-dependent.
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Information theory and robotics meet to study predator-prey ...
Jul 18, 2017 · Here, we propose a robotics-based experimental paradigm to systematically control for the direction of information flow, thereby offering ...Missing: biodiversity | Show results with:biodiversity
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Animal–robot interaction—an emerging field at the intersection of ...
Feb 2, 2024 · The field of animal–robot and organism–robot interaction systems (ARIS, ORIS) is a currently rapidly emerging field in biorobotics.
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The Convergence of AI and animal-inspired robots for ecological ...
Effectiveness of robots in influencing behavior. Animal-inspired robots have been employed to guide animal groups, deter pests, and monitor endangered species, ...