Fact-checked by Grok 2 weeks ago

Causal analysis

Causal analysis, also known as causal inference, is the scientific process of identifying and quantifying cause-and-effect relationships between variables, distinguishing it from mere statistical associations by focusing on the effects of interventions or actions on outcomes.^[1] Unlike correlational analysis, which infers probabilities under stable conditions from joint distributions, causal analysis addresses dynamic scenarios where conditions change, such as through treatments or policies, requiring explicit causal assumptions that cannot be tested solely from observational data.^[2] This field integrates principles from statistics, philosophy, and computer science to answer questions like "What would happen if we intervened?" using tools such as counterfactual reasoning and structural models.^[3] The foundations of causal analysis trace back to early 20th-century developments, including Sewall Wright's path analysis in the 1920s and Jerzy Neyman's work on potential outcomes in 1923, which formalized randomization in experiments.^[3] Modern frameworks, notably Judea Pearl's structural causal models introduced in the 1990s, unify graphical models, potential outcomes, and structural equations to represent causal mechanisms explicitly, enabling identification of effects even in non-experimental settings.^[3] These models use directed acyclic graphs to visualize relationships and criteria like the back-door adjustment to control for confounders, allowing researchers to estimate causal effects from observational data when randomized controlled trials (RCTs) are impractical.^[2] Key methods in causal analysis include RCTs as the gold standard for establishing causality through randomization, which balances covariates and minimizes bias, alongside observational techniques such as instrumental variable analysis, mediation analysis, and difference-in-differences for real-world applications.^[1] Applications span diverse fields, including epidemiology for assessing treatment efficacy, economics for policy evaluation, and machine learning for decision-making systems, where causal insights inform interventions like public health campaigns or algorithmic optimizations.^[2] Despite advances, challenges persist in validating assumptions, handling unmeasured confounding, and scaling methods to high-dimensional data, underscoring the need for robust causal assumptions in empirical research.^[3]

Overview and Fundamentals

Definition and Scope

Causal analysis refers to the systematic process of identifying, modeling, and validating cause-and-effect relationships in various systems, going beyond mere associations or correlations to infer aspects of the underlying data generation process.^[4] Unlike correlation, which describes statistical dependencies observable in data distributions, causal analysis emphasizes how outcomes would change under specific interventions, such as altering an antecedent condition while holding other factors constant.^[4] This distinction is crucial because distributions alone cannot reveal responses to external changes or manipulations.^[4] At its core, causal analysis involves key components: antecedent conditions that precede and trigger effects, intermediary mechanisms through which causes operate, and resultant outcomes, all framed by directionality (e.g., from cause to effect) and the potential for intervention to test or establish these links.^[4] For instance, in a classic example, cigarette smoking serves as an antecedent condition that, through biological mechanisms like DNA damage and inflammation, leads to the outcome of lung cancer, with epidemiological evidence establishing this causal link rather than mere correlation.^[5] Approximately 80-90% of lung cancer cases are attributable to smoking, underscoring the directionality from exposure to disease.^[6] The scope of causal analysis is inherently interdisciplinary, spanning philosophy, where it traces roots to Aristotle's four causes (material, formal, efficient, and final); statistics and economics, through structural equation models and potential outcomes frameworks; physics, via conserved quantities and event relations in fundamental laws; social sciences, including epidemiology and sociology for policy impacts; and artificial intelligence, where causal inference enhances model robustness and fairness.^[7]^[4]^[8]^[9]^[10] Its evolution began with Aristotle's foundational typology in the 4th century BCE, progressed through Newtonian mechanics and 19th-century statistical innovations by figures like Galton and Pearson, and reached modern causal inference in the late 20th century with graphical models and do-calculus pioneered by Judea Pearl.^[7] This broad applicability enables causal analysis to address real-world questions, from scientific experimentation to AI decision-making, while requiring explicit assumptions about interventions.^[10]

Historical Context

The concept of causality has roots in ancient philosophy, particularly in the work of Aristotle, who articulated a theory of the four causes in his treatises Physics and Metaphysics. These causes—material (the substance from which something is made), formal (its defining structure or essence), efficient (the agent or process that brings it about), and final (its purpose or end goal)—provided a comprehensive framework for explaining change and existence in the natural world.^[11] This doctrine profoundly shaped Western thought, influencing medieval scholasticism and early modern science by emphasizing teleological and explanatory principles over mere description.^[11] During the Enlightenment, David Hume challenged metaphysical accounts of causation in his 1748 An Enquiry Concerning Human Understanding, positing that causal relations arise from the constant conjunction of events observed through empirical experience rather than inherent necessity or power.^[12] Hume's skepticism shifted focus toward inductive reasoning and habit-based inference, laying groundwork for empiricist approaches in philosophy and science while critiquing prior reliance on unobservable essences.^[12] In the 19th and 20th centuries, causal analysis evolved toward statistical and econometric methods amid growing data availability. Clive Granger introduced Granger causality in 1969, a test assessing whether one time series can predict another, marking a key advancement in econometrics for detecting temporal precedence in economic data.^[13] Donald Rubin formalized the potential outcomes framework in 1974, defining causal effects as contrasts between hypothetical outcomes under different treatments, enabling rigorous inference in both randomized experiments and observational studies.^[14] Building on probabilistic foundations from the 1980s, Judea Pearl developed do-calculus in 1995 as part of structural causal models, providing graphical rules to identify interventions from observational data without experiments.^[15] Since 2000, causal analysis has increasingly integrated with machine learning, particularly through causal discovery algorithms that automatically infer directed acyclic graphs representing causal structures from observational data. Seminal post-2000 contributions include score-based methods like the NOTEARS algorithm (2018), which optimize continuous penalties to learn causal relations, and hybrid approaches combining constraint and score techniques for scalability in high-dimensional settings.^[16] These advancements have enabled applications in fields like genomics and economics, bridging statistical inference with computational efficiency.^[16]

Philosophical and Theoretical Foundations

Causality in Philosophy

In philosophy, ontological perspectives on causality diverge sharply between realism and nominalism. Realists posit causality as a fundamental relation inherent in the structure of reality, independent of human perception or language, often viewing it as an objective feature that underpins the world's order. This view traces back to ancient thinkers who treated causal connections as essential to explaining change and existence. In contrast, nominalists regard causality not as a real entity or necessary connection but as an illusion or convenient linguistic construct derived from observed patterns, denying it any independent ontological status.^[17] Immanuel Kant, in his Critique of Pure Reason (1781), reconciled these tensions by arguing that causality is a synthetic a priori category of the human mind, imposing necessary structure on sensory experience to make coherent knowledge possible, thus neither purely objective nor subjective. Epistemological challenges to causality center on how we can know or justify causal claims, with David Hume's problem of induction representing a cornerstone critique. In An Enquiry Concerning Human Understanding (1748), Hume contended that our belief in causality stems from habitual association of constant conjunctions—observing event A followed by B repeatedly leads us to expect it again—rather than any rational insight into necessary connections, rendering induction unreliable for future predictions.^[18] This skepticism fueled regularity theories of causation, which define causes as instances of general laws or patterns without invoking hidden powers. J.L. Mackie advanced this in his 1965 paper "Causes and Conditions," proposing INUS conditions: an insufficient but non-redundant part of an unnecessary but sufficient condition for the effect, capturing how everyday causal ascriptions pick out salient factors within complex regularities.^[19] Philosophers distinguish between singular (or token) causation, which pertains to specific, particular events—such as this match igniting this fire—and general (or type) causation, which involves laws or patterns across kinds of events, like friction generally causing ignition.^[20] This distinction highlights that while singular causes explain unique occurrences without requiring universal laws, general causation supports predictive science by linking property types. These philosophical debates profoundly influence scientific realism and determinism, providing the conceptual groundwork for viewing natural laws as causal necessities that determine outcomes, thereby justifying empirical inquiry into an ordered universe.^[21]

Counterfactual and Possible Worlds Approaches

Counterfactual theories of causality analyze causation in terms of hypothetical scenarios where causes are absent or altered, emphasizing dependence between actual and potential outcomes. At the core of this approach is the idea that event C causes event E if E counterfactually depends on C, meaning that if C had not occurred, E would not have occurred. This "what if" reasoning captures the intuitive notion of causation as a contrast between what happened and what would have happened under different conditions, providing a framework for understanding necessary connections without relying solely on observed regularities.^[22] David Lewis formalized this perspective in his 1973 book Counterfactuals, employing possible worlds semantics to define the truth conditions of counterfactual statements. According to Lewis, a counterfactual "If A were the case, then B would be the case" holds true if, in the closest possible world to the actual world where A is true, B is also true. Closeness is determined by a similarity relation among possible worlds, which prioritizes minimal deviation from the actual world—first in spatiotemporal details, then in particular facts, and finally in laws of nature. Lewis also introduced the centering condition, stipulating that the actual world is always the closest to itself, ensuring that true antecedents in the actual world yield true consequents without introducing spurious dependencies. This structure extends to causation, where causal dependence between events is analyzed via chains of such counterfactuals, forming the basis for a reductive account of causality in terms of logical and modal relations.^[22] Subsequent refinements addressed limitations in Lewis's framework, particularly regarding its application to events and integration with empirical practices. Jonathan Bennett, in Events and Their Names (1988), critiqued Lewis's treatment of counterfactual dependence for events, arguing that it inadequately distinguishes between causal relations and mere correlations by over-relying on propositional semantics; he proposed revisions emphasizing the ontology of events to better align counterfactual analysis with ordinary language and thought about actions and occurrences. James Woodward, in Making Things Happen (2003), further developed the approach by linking counterfactuals to interventionist accounts, where causation is defined by patterns of counterfactual variation under hypothetical manipulations, thus grounding possible worlds in testable, manipulable relationships rather than purely metaphysical similarity. These refinements preserve the core possible worlds machinery while enhancing its applicability to concrete explanatory contexts.^[23]^[24] Counterfactual and possible worlds approaches have significant applications in legal liability and decision theory. In law, the "but-for" test employs counterfactual reasoning to establish factual causation, asking whether the plaintiff's injury would have occurred absent the defendant's conduct, thereby determining responsibility in tort and criminal cases. In decision theory, Lewis's framework underpins causal decision theory, where rational agents evaluate choices by considering counterfactual outcomes in possible worlds, distinguishing genuine causal influences from evidential correlations to guide actions under uncertainty.^[25]^[22]

Scientific and Operational Frameworks

Causality in Physics and Natural Sciences

In classical mechanics, causality manifests through the deterministic structure of Newton's laws of motion, which dictate that the future state of a physical system is uniquely determined by its initial conditions and the forces acting upon it. Newton's third law, stating that every action has an equal and opposite reaction, establishes a reciprocal causal relationship between interacting bodies, ensuring that forces propagate instantaneously in the Newtonian framework. This determinism implies perfect predictability, as exemplified by Pierre-Simon Laplace's 1814 thought experiment of a "demon" that, possessing complete knowledge of all particle positions and velocities at a single moment, could compute the entire past and future of the universe. Albert Einstein's theory of special relativity, published in 1905, reframes causality within a four-dimensional spacetime where the speed of light serves as an absolute limit, preventing influences from propagating faster than light. The light cone structure arising from this theory defines causal connectability: an event can causally affect only those within its future light cone, while events in the spacelike region outside remain causally disconnected, thereby preserving the temporal order of cause preceding effect across all inertial frames. This formulation eliminates the instantaneous action at a distance of classical mechanics, replacing it with a relativistic causal horizon that aligns with experimental observations of light propagation.^[26] Quantum mechanics shifts causation toward a probabilistic paradigm, where the Schrödinger equation governs wave function evolution deterministically, but measurement outcomes introduce inherent randomness, undermining classical predictability. John Bell's 1964 theorem reveals that quantum correlations cannot be explained by local hidden variables preserving both realism and locality, as they violate Bell inequalities derived from such assumptions, thus challenging the notion of local causal influences in entangled systems. Interpretations like Bohmian mechanics, proposed by David Bohm in 1952, seek to restore determinism through non-local hidden variables that guide particle trajectories via the quantum potential, allowing superluminal influences while reproducing quantum predictions.^[27]^[28] In general relativity, operational causality is enforced through conditions that prohibit spacetime geometries permitting closed timelike curves, which would enable causal loops and backward time travel. Stephen Hawking and George Ellis, in their 1973 analysis, defined hierarchical causality conditions—such as global hyperbolicity and stable causality—to ensure spacetimes remain free of such violations, requiring that no non-spacelike curve intersects itself and that small metric perturbations preserve causal structure. These conditions underpin the physical viability of cosmological models, excluding solutions like those in rotating universes that might otherwise allow acausal paradoxes.^[29]

Statistical and Probabilistic Definitions

In statistical and probabilistic frameworks, causality is often defined through improvements in prediction or conditional probabilities rather than deterministic mechanisms. One foundational approach is probabilistic causation, as formalized by Patrick Suppes, where an event A is considered a prima facie cause of a subsequent event B if A temporally precedes B and the probability of B given A exceeds the probability of B in the absence of A. This condition is expressed mathematically as P(B \mid A) > P(B \mid \neg A), establishing a basic asymmetry in probabilistic dependence that suggests causation but does not rule out spurious associations arising from common causes. Suppes further distinguishes spurious causation, where the apparent probabilistic link between A and B is explained by a third variable influencing both, requiring additional tests to confirm genuine causal influence. A related concept in time-series analysis is Granger causality, introduced by Clive Granger to assess whether one variable provides statistically significant information about future values of another beyond what is already contained in the latter's own past. Specifically, a variable X is said to Granger-cause Y if the conditional distribution of Y_t given the past of Y is altered by including the past of X, or more operationally, if the mean squared prediction error of Y decreases when forecasts incorporate past values of X alongside those of Y. This is formalized as the variance of the prediction error being lower under the augmented model: if \sigma^2(Y_t \mid \{Y_{t-1}, Y_{t-2}, \dots\}) > \sigma^2(Y_t \mid \{Y_{t-1}, Y_{t-2}, \dots, X_{t-1}, X_{t-2}, \dots\}), then X Granger-causes Y, testable via F-statistics in autoregressive models. Granger causality emphasizes predictive utility in stochastic processes but does not imply mechanistic causation, as it can be confounded by non-stationarities or omitted variables.^[13] Judea Pearl's do-calculus provides a rigorous probabilistic framework for identifying causal effects from observational data by distinguishing interventions from mere conditioning. The do-operator, denoted P(Y \mid do(X = x)), represents the distribution of Y under an intervention that sets X to x, severing incoming arrows to X in a causal graph to model hypothetical manipulations. This interventional probability quantifies the causal effect of X on Y, contrasting with the observational P(Y \mid X = x), which may include confounding biases. The backdoor criterion offers a key identification rule: if a set Z blocks all backdoor paths from X to Y (non-directed paths into X), the causal effect is identifiable via adjustment as P(Y \mid do(X = x)) = \sum_z P(Y \mid X = x, Z = z) P(Z = z), stratifying over Z to eliminate confounding. Do-calculus comprises three inference rules enabling reduction of interventional queries to observational ones under conditional independence assumptions, facilitating causal inference without experiments. Confounding and mediation further refine probabilistic causal definitions by decomposing effects along pathways. Confounding occurs when a common cause distorts the apparent effect of X on Y, resolvable by adjustment sets as in the backdoor formula above. In mediation analysis, the total causal effect of X on Y, P(Y \mid do(X)), partitions into direct effects (not mediated by intermediates) and indirect effects (transmitted through mediators like M). Path analysis, originating with Sewall Wright, quantifies these by tracing correlations through directed paths: the total effect sums direct path coefficients plus indirect ones via mediators, with the indirect effect computed as the product of path coefficients along mediating routes (e.g., X → M → Y). Pearl extended this to non-linear settings, defining the pure direct effect as \sum_m P(Y \mid X = x', M = m, do(X = x)) P(M = m \mid do(X = x)), holding the mediator at natural levels under intervention, while the indirect effect captures mediation-specific transmission. These decompositions highlight how probabilistic dependencies can isolate causal pathways amid confounding.^[30]^[31]

Methods of Causal Inference

Experimental Designs

Experimental designs represent a cornerstone of causal analysis, enabling researchers to establish causal relationships through controlled interventions that minimize confounding influences. Unlike observational methods, these designs actively manipulate the treatment or exposure variable to observe its effects, providing the strongest evidence for causality by approximating the ideal of comparing what would happen under different conditions for the same units. The primary goal is to achieve balance between treatment and control groups, ensuring that observed differences in outcomes can be attributed to the intervention rather than pre-existing differences.^[32] Randomized controlled trials (RCTs) are widely regarded as the gold standard for causal inference due to their ability to eliminate selection bias and other sources of confounding through random assignment of participants to treatment and control groups. In an RCT, eligible subjects are randomly allocated to either receive the intervention (treatment group) or a placebo or standard care (control group), which ensures that, on average, the groups are comparable in both observed and unobserved characteristics at baseline. This randomization process balances potential outcomes across groups, allowing the average treatment effect to be estimated as the difference in means between the groups. For instance, in clinical settings, RCTs have been pivotal in evaluating drug efficacy, such as the 1948 streptomycin trial for tuberculosis, which demonstrated the causal impact of the antibiotic on survival rates.^[32]^[33]^[34] Key principles underlying RCTs include achieving counterfactual balance through randomization, which aligns with the potential outcomes framework by making the distribution of untreated outcomes similar across groups in expectation. Intention-to-treat (ITT) analysis is another fundamental principle, wherein all randomized participants are analyzed according to their original group assignment, regardless of compliance or dropout, to preserve randomization and provide an unbiased estimate of the effect of assigning the treatment. This approach mitigates biases from non-compliance but may dilute the estimated effect if adherence is low. Additionally, power calculations are essential for determining adequate sample size to detect a meaningful effect with sufficient statistical power, typically set at 80% (β = 0.20) and a significance level of α = 0.05. The standard formula for the sample size per group in a two-arm RCT assuming equal variances and a two-sided test is:

n = \frac{(Z_{1-\alpha/2} + Z_{1-\beta})^2 \cdot 2\sigma^2}{\delta^2}

where Z_{1-\alpha/2} is the Z-score for the desired confidence level, Z_{1-\beta} is the Z-score for power, \sigma is the standard deviation of the outcome, and \delta is the minimum detectable effect size; this formula ensures the study is neither underpowered nor excessively costly.^[34]^[35]^[36] When full randomization is infeasible—due to ethical, logistical, or practical constraints—quasi-experimental designs offer robust alternatives for causal inference by exploiting natural or policy-induced variations. Interrupted time series (ITS) designs analyze repeated measures of an outcome before and after an intervention to detect changes in level or trend, assuming that any abrupt shift attributable to the intervention distinguishes it from secular trends. For example, ITS has been used to evaluate public health policies like smoking bans by comparing pre- and post-implementation rates of hospital admissions for respiratory issues, controlling for autocorrelation and seasonality through segmented regression models. Similarly, regression discontinuity designs (RDD) leverage a cutoff score or threshold that determines treatment eligibility, estimating causal effects by comparing outcomes just above and below the cutoff, where units are otherwise similar. This local randomization around the threshold mimics an RCT, as seen in studies of scholarship programs where eligibility based on test scores creates a sharp discontinuity in outcomes like college enrollment. Both designs strengthen causal claims when combined with covariates to address potential threats like maturation or instrumentation effects.^[37]^[38]^[37] Ethical considerations are paramount in experimental designs involving human subjects, with the Declaration of Helsinki (1964) establishing foundational principles such as informed consent, risk minimization, and equitable subject selection to protect participants while advancing scientific knowledge. This declaration, adopted by the World Medical Association, mandates that the well-being of individuals supersede scientific interests and requires independent ethical review, influencing global standards for RCTs and quasi-experiments.^[39]

Observational Data Techniques

Observational data techniques enable causal inference in settings where randomized experiments are infeasible, relying on statistical adjustments to mitigate confounding from non-random treatment assignment. These methods assume no unmeasured confounders or employ strategies to isolate exogenous variation, drawing on pre-existing data from surveys, administrative records, or registries. Unlike experimental designs that manipulate treatments, these approaches analyze naturally occurring variations while invoking assumptions like ignorability or parallel trends to approximate causal effects.^[40] Instrumental variables (IV) estimation identifies causal effects by leveraging exogenous sources of variation in treatment assignment that do not directly affect outcomes except through the treatment. An instrument must satisfy two validity conditions: relevance, meaning it strongly predicts treatment receipt, and exclusion, ensuring it influences the outcome solely via the treatment. For linear models, two-stage least squares (2SLS) implements IV by first regressing the endogenous treatment on the instrument and covariates to obtain predicted values, then regressing the outcome on these predictions and covariates; the coefficient on the predicted treatment estimates the local average treatment effect (LATE) for compliers—those whose treatment status changes with the instrument. This approach, formalized in the principal strata framework, has been widely applied in econometrics to address endogeneity, such as using distance to college for estimating returns to education.^[41] Propensity score matching constructs comparable treated and control groups by balancing observed covariates, approximating randomization within strata defined by the probability of treatment. The propensity score is defined as the conditional probability of treatment given covariates, modeled via logistic regression:

\text{logit}(P(T=1 \mid X)) = \beta X,

where T is the treatment indicator and X are covariates; the score e(X) = P(T=1 \mid X) summarizes covariate information into a scalar. Matching pairs units with similar scores, often using caliper restrictions to limit distance (e.g., nearest-neighbor matching within 0.2 standard deviations of the score's logit) to reduce bias from covariate imbalance. This method reduces dimensionality in high-dimensional settings and estimates average treatment effects on the treated (ATT) under conditional independence, assuming no unmeasured confounding.^[40] Difference-in-differences (DiD) exploits temporal changes in outcomes between treated and control groups before and after an intervention, assuming parallel trends in the absence of treatment. The causal effect is estimated as the difference in post-treatment outcomes between groups minus the pre-treatment difference:

(\bar{Y}_{\text{post, treat}} - \bar{Y}_{\text{post, control}}) - (\bar{Y}_{\text{pre, treat}} - \bar{Y}_{\text{pre, control}}),

where \bar{Y} denotes group-time means; this isolates the treatment effect under the assumption that unconfounded trends are common across groups. Seminal applications, like evaluating New Jersey's 1992 minimum wage increase using Pennsylvania as a control, found no employment reduction, challenging traditional models. However, serial correlation in panel data can inflate standard errors, requiring clustered inference or wild bootstrap adjustments for validity.^[42]^[43] Sensitivity analyses assess robustness to unmeasured confounding by bounding how much hidden bias could alter conclusions from primary estimates. For matched observational studies, Rosenbaum bounds quantify the departure from randomization needed to nullify significance, parameterizing bias via odds ratios of differential treatment assignment due to an unobserved confounder. For a binary outcome and matched pairs, the bound on the treatment effect's p-value widens as the sensitivity parameter \Gamma (maximum odds ratio) increases; inferences robust to \Gamma > 2 indicate low sensitivity. These bounds, derived from permutation tests adjusted for bias, aid in evaluating the plausibility of unmeasured confounders without specifying their form.^[44]

Graphical and Structural Models

Graphical and structural models provide formal frameworks for representing and analyzing causal relationships, enabling the visualization of dependencies and the identification of causal effects from observational data. These models typically employ directed acyclic graphs (DAGs) to depict variables as nodes and causal influences as directed edges, ensuring no cycles to reflect the acyclic nature of causation. In a DAG, the absence of directed paths from one node to another implies potential conditional independencies, which are rigorously captured by the concept of d-separation: two sets of variables are d-separated given a third set if every path between them is blocked by conditioning on the third set, implying conditional independence under the graph's Markov assumptions. This graphical criterion allows researchers to read off independencies directly from the structure without exhaustive statistical testing.^[45] Structural causal models (SCMs) extend DAGs by assigning deterministic functions to each endogenous variable, incorporating exogenous noise terms to model probabilistic behavior. Formally, an SCM consists of a DAG together with equations of the form Y = f_Y(\mathbf{PA}_Y, U_Y), where \mathbf{PA}_Y are the parents of Y in the DAG, and U_Y is an exogenous noise variable independent of all other exogenous variables. These models distinguish between observational and interventional distributions; the do-operator, denoted do(X = x), simulates interventions by setting X = x and truncating incoming edges to X, yielding P(Y | do(X = x)) = \sum_u P(Y | X = x, \mathbf{PA}_X = \mathbf{pa}_X, u) P(u | \mathbf{PA}_X = \mathbf{pa}_X), which identifies causal effects when back-door paths are absent or adjustable. SCMs thus facilitate both identification of effects and reasoning about counterfactuals by solving the model under modified conditions.^[3] Causal discovery algorithms aim to infer the DAG structure from data, assuming faithfulness (independencies in data reflect those in the graph) and no hidden confounders in basic cases. The PC algorithm, introduced by Spirtes, Glymour, and Scheines, is a seminal constraint-based method that first constructs an undirected skeleton by testing conditional independencies of increasing order, then orients edges using v-structures (colliders) and acyclicity constraints to yield a completed partially directed acyclic graph (CPDAG). It operates in phases: starting with a complete graph, it removes edges for unconditional independencies, then conditions on subsets to prune further, and finally applies orientation rules to avoid new v-structures or cycles. Constraint-based methods like PC rely on independence tests (e.g., partial correlations for Gaussian data) to enforce graphical constraints, making them efficient for high-dimensional settings but sensitive to test errors.^[46] In contrast, score-based methods evaluate candidate DAGs by maximizing a scoring function that balances fit to data (e.g., BIC or AIC penalizing complexity) and structural simplicity, often using greedy search or optimization over equivalence classes. These approaches, such as the greedy equivalence search (GES), handle latent variables better and avoid multiple testing issues inherent in constraint-based tests, though they require specifying priors or scores tailored to the data-generating process. Hybrid methods combine both paradigms, using constraints to narrow the search space before score optimization, improving robustness in practice. While constraint-based methods excel in sparse graphs with clear independencies, score-based ones perform well in dense or noisy settings, with choice depending on assumptions about the underlying causal structure.^[47] Within these models, interventions and counterfactuals are analyzed via identification criteria like the front-door criterion, which applies when a mediator set Z intercepts all paths from treatment X to outcome Y, no back-door paths from X to Z, and all back-door paths from Z to Y are blocked by X. The causal effect is then identifiable as:

P(Y | do(X = x)) = \sum_z P(Z = z | X = x) \sum_{x'} P(Y | X = x', Z = z) P(X = x')

This formula recovers the interventional distribution from observational data by first estimating the effect of X on Z, then the effect of Z on Y stratified by X, providing a pathway to causation when direct adjustment fails due to unmeasured confounding. The criterion leverages the graph's structure to bypass unobservable variables, a key strength of graphical and structural approaches.^[3]

Applications Across Disciplines

In Epidemiology and Medicine

In epidemiology and medicine, causal analysis is essential for identifying disease etiologies, evaluating interventions, and informing public health policies. It bridges observed associations between exposures and health outcomes to establish causal relationships, often using frameworks that integrate biological plausibility with statistical evidence. This approach has transformed clinical practice by enabling the differentiation of correlation from causation, particularly in studying chronic diseases and infectious agents.^[48] A foundational tool for causal inference in observational data is the Bradford Hill criteria, outlined in 1965 by epidemiologist Austin Bradford Hill. These nine viewpoints guide the assessment of whether an observed association likely reflects a causal link: strength measures the magnitude of the association; consistency evaluates replication across studies; specificity assesses if the exposure leads to a particular outcome; temporality requires the cause to precede the effect; biological gradient examines dose-response patterns; plausibility considers biological feasibility; coherence ensures alignment with known facts; experiment incorporates evidence from interventions; and analogy draws parallels from similar exposures. While not a checklist for definitive proof, these criteria have been widely applied to strengthen causal claims in medical research.^[48] Observational studies, such as case-control and cohort designs, play a central role in causal analysis by estimating measures like odds ratios and relative risks. In case-control studies, which retrospectively compare individuals with (cases) and without (controls) the outcome, the odds ratio approximates the relative risk when the outcome is rare, quantifying the association between exposure and disease.^[49] Cohort studies, which prospectively follow exposed and unexposed groups, directly compute relative risks as the ratio of outcome incidence in the exposed group to the unexposed group, providing stronger temporal evidence for causality.^[50] The Framingham Heart Study, initiated in 1948, exemplifies cohort-based causal inference; it tracked over 5,000 participants biennially, establishing relative risks for cardiovascular disease linked to factors like hypertension (e.g., elevated blood pressure increasing risk by 2-3 times), smoking, and high cholesterol, thereby identifying modifiable causes and influencing global prevention strategies.^[51] Randomized controlled trials further refine causal estimates in medicine through survival analysis, where hazard ratios compare the instantaneous risk of events (e.g., disease progression) between treatment arms over time. For infectious disease interventions, vaccine efficacy is calculated as the attributable reduction in incidence:

\text{VE} = 1 - \frac{I_v}{I_u}

where I_v is the incidence rate in the vaccinated group and I_u in the unvaccinated group, often derived from trial data to demonstrate protective effects.^[52] Causal evidence from such analyses has driven major policy changes, as seen in tobacco control. The 1964 U.S. Surgeon General's Report concluded that cigarette smoking causes lung cancer (with smokers facing 9-10 times the risk of non-smokers), chronic bronchitis, emphysema, and coronary heart disease, based on epidemiological data establishing temporality and dose-response. This report catalyzed regulations, including warning labels and advertising bans, reducing U.S. smoking prevalence from 42% in 1964 to 18% by 2014 and further to 11.5% as of 2023, averting millions of deaths.^[53]^[54] Recent applications include causal inference in evaluating COVID-19 interventions, such as vaccine efficacy and lockdown effects using difference-in-differences, highlighting the field's role in real-time public health decision-making.^[55] In social sciences and economics, causal analysis is pivotal for evaluating policy interventions and understanding behavioral mechanisms that influence outcomes such as employment, education, and decision-making. Econometric methods, particularly natural experiments, allow researchers to approximate randomized controlled trials by exploiting exogenous variations in policy implementation. A landmark example is the study of the 1992 New Jersey minimum wage increase from $4.25 to $5.05 per hour, which used a difference-in-differences (DiD) approach comparing fast-food employment in New Jersey to neighboring Pennsylvania, where no such increase occurred. This analysis found no significant employment loss and even suggested a slight increase in jobs, challenging traditional predictions from competitive labor market models.^[56] In education research, lotteries for oversubscribed schools provide quasi-random assignment, enabling causal estimates of school quality on student achievement. For instance, lotteries in Boston's charter schools have been used to assess the impact of enrollment on test scores, revealing substantial gains in math and reading for lottery winners who attended compared to those who did not, with effects equivalent to 0.2 to 0.4 standard deviations per year. These findings highlight how charter school structures, such as extended instructional time and high-stakes accountability, drive causal improvements in educational outcomes. Mediation analysis extends causal inference by decomposing effects into direct and indirect pathways, particularly useful in social programs like job training. In evaluations of the Job Corps program, a federal initiative providing vocational training to disadvantaged youth, mediation techniques with instrumental variables have quantified how training affects earnings through intermediate channels such as hours worked. Results indicate that the program's positive earnings impact operates primarily through increased labor force attachment (hours worked), with little direct effect via enhanced human capital.^[57] Policy evaluation often employs instrumental variables (IV) to address endogeneity, yielding the local average treatment effect (LATE), which estimates impacts for subpopulations affected by the instrument. In heterogeneous settings, such as estimating the returns to education using draft lotteries as instruments, LATE reveals effects specific to "compliers"—those whose behavior changes due to the instrument—typically showing earnings increases of about 7% per additional year of schooling for this group.^[58] This approach is widely adopted in economics for policies like subsidies or regulations, where full population effects are unidentifiable due to selection biases. In behavioral economics, nudge theory posits that subtle changes in choice architecture can guide decisions without restricting options, with causal evidence from default settings demonstrating their potency. Thaler and Sunstein's framework, applied to defaults like automatic enrollment in retirement savings plans, has been tested empirically; for example, switching from opt-in to opt-out defaults increased participation rates from around 20% to over 90% in 401(k plans, illustrating how inertia and status quo bias causally boost savings behavior. Such interventions have informed policies worldwide, emphasizing low-cost ways to align individual choices with long-term welfare.

Challenges and Limitations

Identification Problems

In causal inference, the fundamental problem arises from the inherent impossibility of directly observing both potential outcomes for the same unit under different treatments, making it challenging to estimate causal effects without additional assumptions. This issue, articulated by Holland, stems from the fact that a unit can receive only one treatment at a time, preventing simultaneous observation of the counterfactual outcome that would have occurred under the alternative treatment.^[59] As a result, causal effects must be inferred indirectly from group-level comparisons, often relying on randomization or other identification strategies to approximate the missing counterfactuals.^[59] Confounding represents a key identification barrier where extraneous variables distort the observed association between treatment and outcome, leading to biased estimates of causal effects. It occurs when a confounder influences both the treatment assignment and the outcome, violating the principle of exchangeability, which requires that treated and untreated groups have identical distributions of potential outcomes conditional on observed covariates.^[60] Confounders can be measured, allowing for potential adjustment through stratification or modeling, or unmeasured, which introduces untestable assumptions and persistent bias if overlooked.^[60] For instance, unmeasured confounding implies that even after conditioning on all observed variables, the potential outcomes remain non-exchangeable across treatment groups.^[60] Endogeneity complicates identification when the explanatory variable correlates with the error term in a regression model, often due to simultaneous causation or reverse causality, where the outcome influences the treatment rather than solely vice versa. In cases of simultaneity, treatment and outcome mutually determine each other, such as in supply-demand equilibria, rendering ordinary least squares estimates inconsistent.^[61] Reverse causality similarly induces correlation between the treatment and unobserved factors affecting the outcome, biasing causal inferences.^[61] Addressing these requires assumptions like temporal ordering, where treatment precedes the outcome, enabling the use of lagged variables to isolate directional effects.^[61] Selection bias emerges as another identification challenge when the study sample is not representative of the target population, particularly through collider stratification, where conditioning on a common effect of treatment and outcome induces spurious associations. This bias distorts the treatment-outcome relationship by creating dependencies that did not exist marginally in the population.^[62] A classic example is Berkson's paradox in epidemiology, where hospital admission serves as a collider influenced by both an exposure (e.g., diabetes) and a disease (e.g., cholecystitis); stratifying on hospitalized patients induces a negative association between these independent conditions.^[62] Graphical models can help detect such colliders, though detailed strategies for mitigation lie beyond this discussion.^[60]

Ethical and Practical Issues

Causal analysis, particularly through randomized controlled trials (RCTs), raises significant ethical concerns regarding participant welfare and the potential for harm. Random assignment to treatment arms can expose individuals to suboptimal interventions, especially when one arm is known to be inferior, as seen in high-stakes trials like those for glioblastoma where control group mortality reached 97% compared to 88% in the treatment group.^[63] Informed consent processes must address therapeutic misconception, where participants overestimate personal benefits, and ensure comprehension of risks, drawing from historical abuses like the Tuskegee syphilis study that underscored the need for voluntary participation.^[64] The use of placebos introduces deception and potential harm if effective treatments exist, though it is ethically permissible under the Declaration of Helsinki when no proven intervention is available and no serious risks arise.^[64] Equipoise, or genuine professional uncertainty about treatment superiority, is essential to justify randomization, but challenges arise in defining whose judgment matters—individual physicians, communities, or ethical boards—and in maintaining it as trial data emerges.^[64] In observational causal inference, ethical issues extend to fairness and bias, particularly when modeling immutable social categories like race or gender as causal factors, which can perpetuate discrimination by overlooking historical confounders such as educational disparities.^[65] Post-treatment conditioning, such as adjusting for interview scores in hiring analyses, may mask upstream biases, leading to unfair policy recommendations that disadvantage marginalized groups.^[65] Privacy concerns also emerge in using sensitive data for causal discovery, requiring robust protections to prevent re-identification while enabling inference.^[66] Practical challenges in causal analysis often stem from untestable assumptions and data limitations, especially in observational studies where unobserved confounding can bias estimates, necessitating triangulation across multiple designs to bolster credibility.^[67] For instance, emulating RCTs with observational data demands careful alignment on eligibility, treatment strategies, and follow-up, but risks like immortal time bias or reverse causation undermine temporality.^[67] In causal machine learning, transparency is a key hurdle; black-box models like causal forests provide heterogeneous treatment effects but lack global interpretability, complicating accountability in policy evaluations such as education interventions.^[68] Scalability and computational complexity further impede practical implementation, as algorithms for causal discovery in high-dimensional data are often NP-complete, limiting their use in real-world systems with interference or temporal dynamics.^[66] Model misspecification, including errors in directed acyclic graphs, can propagate significant biases, while sensitivity analyses are essential yet underutilized for robustness.^[66] Generalizing causal effects across populations remains challenging due to covariate shifts, requiring new identification strategies like proximal inference with negative controls to handle complex, non-experimental settings.^[1]

References

[1]
The Importance of Being Causal - Harvard Data Science Review
Jul 30, 2020 · Causal inference is the study of how actions, interventions, or treatments affect outcomes of interest.
[2]
An Introduction to Causal Inference - PMC - PubMed Central
Causal analysis goes one step further; its aim is to infer probabilities under conditions that are changing, for example, changes induced by treatments or ...
[3]
[PDF] Causal inference in statistics: An overview - UCLA
Abstract: This review presents empirical researchers with recent advances in causal inference, and stresses the paradigmatic shifts that must be un-.
[4]
[PDF] Causal Inference in Statistics: A Gentle Introduction - UCLA
Causal analysis goes one step further; its aim is to infer aspects of the data generation process. With the help of such aspects, one can deduce not only ...<|control11|><|separator|>
[5]
Lung Cancer Risk Factors | Smoking & Lung Cancer
Smoking is by far the leading risk factor for lung cancer. About 80% of lung cancer deaths are thought to result from smoking.Tobacco Smoke · Exposure To Other... · Smoking Marijuana
[6]
Smoking and Lung Cancer: The Role of Inflammation - PMC - NIH
It is estimated that cigarette smoking explains almost 90% of lung cancer risk in men and 70 to 80% in women. Clinically evident lung cancers have multiple ...
[7]
[PDF] An Outline of the History of Methods of Discovering Causality
Aristotle's writings on scientific method contain essentially nothing about experiments in the modern sense and how to conduct them. It is no surprise that ...
[8]
Causation in Physics - Stanford Encyclopedia of Philosophy
Aug 24, 2020 · Causal relations are relations among spatio-temporally localized events, yet fundamental physical laws relate entire global time-slices. Call ...Different Philosophical Projects · Conserved Quantity Accounts...
[9]
Causal Inference in the Social Sciences - Annual Reviews
Apr 22, 2024 · Knowledge of causal effects is of great importance to decision makers in a wide variety of settings. In many cases, however, these causal ...
[10]
Implications of causality in artificial intelligence - Frontiers
Aug 20, 2024 · Causal AI emphasizes identifying cause-and-effect relationships and plays a crucial role in creating more robust and reliable systems.
[11]
Aristotle on Causality - Stanford Encyclopedia of Philosophy
Jan 11, 2006 · Aristotle developed a theory of causality which is commonly known as the doctrine of the four causes.The Four Causes · The Four Causes and the... · The Explanatory Priority of...
[12]
David Hume - Stanford Encyclopedia of Philosophy
Feb 26, 2001 · Hume's method dictates his strategy in the causation debate. In the critical phase, he argues that his predecessors were wrong: our causal ...
[13]
Investigating Causal Relations by Econometric Models and Cross ...
3 (July, 1969) ... ' A discussion of the interpretation of phase diagrams in terms of time lags may be found in Granger and Hatanaka [4, Chapter 5].
[14]
Estimating causal effects of treatments in randomized ... - APA PsycNet
Citation. Rubin, D. B. (1974). Estimating causal effects of treatments in randomized and nonrandomized studies. Journal of Educational Psychology, 66(5), 688– ...Missing: URL | Show results with:URL
[15]
[PDF] The Do-Calculus Revisited Judea Pearl Keynote Lecture, August 17 ...
Aug 17, 2012 · The do-calculus was developed in 1995 to facilitate the identification of causal effects in non-parametric mod-.
[16]
[PDF] A Survey on Causal Discovery: Theory and Practice - arXiv
Aug 26, 2025 · In this paper, we explore recent advancements in causal discovery in a unified manner, provide a consis- tent overview of existing algorithms ...
[17]
[PDF] Hume's Considered View on Causality - PhilSci-Archive
Abstract. Hume presents two definitions of cause in his Enquiry which correspond to his two definitions in his Treatise. The first of the definitions is ...<|control11|><|separator|>
[18]
An Enquiry Concerning Human Understanding - Project Gutenberg
Enquiries concerning the human understanding, and concerning the principles of morals, by David Hume.IV. Sceptical Doubts... · Sceptical Solution of these... · VIII. Of Liberty and Necessity
[19]
[PDF] Causes and Conditions - Joel Velasco
Causes and Conditions. Author(s): J. L. Mackie. Source: American Philosophical Quarterly, Vol. 2, No. 4 (Oct., 1965), pp. 245-264. Published by: University of ...Missing: primary | Show results with:primary
[20]
[PDF] Hitchcock - Singular vs General Causation
For example, I disagree with Sober (1985), who maintains that probabilistic theories provide the best account of general causation, while something like the ...
[21]
[PDF] Causal, Experimental, and Structural Realisms - OpenScholar
This account of scientific realism and scientific empiricism in terms of the discovery of causal factors via experimental isolation requires us to say something ...
[22]
Counterfactuals - David K. Lewis - PhilPapers
Counterfactuals is David Lewis' forceful presentation of and sustained argument for a particular view about propositions which express contrary to fact ...Missing: pdf | Show results with:pdf
[23]
Jonathan Bennett, Events and their Names - PhilPapers
In this study of events and their places in our language and thought, Bennett propounds and defends views about what kind of item an event is.
[24]
Making things happen: a theory of causal explanation - PhilPapers
Woodward's long awaited book is an attempt to construct a comprehensive account of causation explanation that applies to a wide variety of causal and ...
[25]
Causation in the Law - Stanford Encyclopedia of Philosophy
Oct 3, 2019 · Such a test asks a counterfactual question: “but for the defendant's action, would the victim have been harmed as she was?” This test is also ...
[26]
Zur Elektrodynamik bewegter Körper - Einstein - Wiley Online Library
Zur Elektrodynamik bewegter Körper - Einstein - 1905 - Annalen der Physik - Wiley Online Library.
[27]
[PDF] ON THE EINSTEIN PODOLSKY ROSEN PARADOX*
THE paradox of Einstein, Podolsky and Rosen [1] was advanced as an argument that quantum mechanics could not be a complete theory but should be supplemented ...
[28]
A Suggested Interpretation of the Quantum Theory in Terms of ...
The usual quantum theory uses wave functions for probable results. This paper suggests hidden variables determine precise behavior, averaged in measurements.Missing: original | Show results with:original
[29]
The Large Scale Structure of Space-Time
Einstein's General Theory of Relativity leads to two remarkable predictions: first, that the ultimate destiny of many massive stars is to undergo ...
[30]
The Method of Path Coefficients - Project Euclid
The Method of Path Coefficients. Sewall Wright. DOWNLOAD PDF + SAVE TO MY LIBRARY. Ann. Math. Statist. 5(3): 161-215 (September, 1934).
[31]
Direct and indirect effects - ACM Digital Library
This paper presents a new way of defining the effect transmitted through a restricted set of paths, without controlling variables on the remaining paths.Missing: original | Show results with:original
[32]
Randomised controlled trials—the gold standard for effectiveness ...
Dec 1, 2018 · RCTs are the gold-standard for studying causal relationships as randomization eliminates much of the bias inherent with other study designs.
[33]
Randomization in clinical studies - PMC - NIH
Randomization eliminates accidental bias, including selection bias, and provides a base for allowing the use of probability theory.
[34]
Squeezing observational data for better causal inference
Randomised controlled trials (RCTs) are typically viewed as the gold standard for causal inference. This is because effects of interest can be identified ...
[35]
Intent-to-Treat vs. Non-Intent-to-Treat Analyses under Treatment ...
Intent-to-treat analysis aims to estimate the effect of treatment as offered, or as assigned. This analysis entails comparisons of randomized groups and include ...
[36]
Principles of sample size calculation - PMC - NIH
Few Solved Examples · (A) Sample size for one mean, normal distribution. n = Z α + Z β 2 × σ 2 d 2 · (B) Sample size for two means, quantitative data. n = Z α + Z ...
[37]
Quasi-Experimental Designs for Causal Inference - PMC
This article discusses four of the strongest quasi-experimental designs for identifying causal effects: regression discontinuity design, instrumental variable ...
[38]
Use of Interrupted Time Series Analysis in Evaluating Health Care ...
ITS is best understood as a simple but powerful tool used for evaluating the impact of a policy change or quality improvement program on the rate of an outcome.
[39]
WMA Declaration of Helsinki – Ethical Principles for Medical ...
Medical research involving human participants must be conducted only by individuals with the appropriate ethics and scientific education, training and ...
[40]
The Central Role of the Propensity Score in Observational Studies ...
The central role of the propensity score in observational studies for causal ... (Cochran, 1965; Rubin, 1983), namely, matched sampling, subclassification, and.Missing: pdf | Show results with:pdf
[41]
Identification of Causal Effects Using Instrumental Variables - jstor
We outline a framework for causal inference in settings where assignment to a binary treatment is ignorable, but compliance with.
[42]
[PDF] Working Paper No. 4509 - National Bureau of Economic Research
On April 1, 1992 New Jersey's minimum wage increased from $4.25to $5.05 per hour. To evaluate the impact of the law we surveyed 410 fast food restaurants in New ...Missing: 1994 | Show results with:1994
[43]
How Much Should We Trust Differences-in-Differences Estimates?
Current Population Survey. For each law, we use OLS to compute the DD estimate of its "effect" as well as the standard error of this estimate. These.
[44]
Sensitivity analysis for certain permutation inferences in matched ...
A sensitivity analysis in an observational study is an attempt to display and clarify the extent to which inferences about a treatment effect vary over a range ...
[45]
d-SEPARATION WITHOUT TEARS (At the request of many readers)
d-separation is a criterion for deciding, from a given a causal graph, whether a set X of variables is independent of another set Y, given a third set Z.
[46]
Causation, Prediction, and Search - SpringerLink
This book is intended for anyone, regardless of discipline, who is interested in the use of statistical methods to help obtain scientific explanations.Missing: PC | Show results with:PC
[47]
[PDF] Constraint-Based, Score-based or Hybrid Algorithms?
Constraint-based algorithms use conditional independence tests, score-based use goodness-of-fit scores, and hybrid algorithms combine both approaches.
[48]
The Environment and Disease: Association or Causation? - PMC - NIH
Austin Bradford Hill ... This article has been reprinted. See "The environment and disease: association or causation?" in Bull World Health Organ, volume 83 on ...
[49]
[PDF] Case-Control Studies - UNC Gillings School of Public Health
In these case-control studies, the odds ratio provides a valid estimate of the risk ratio without assuming that the disease is rare in the source population.
[50]
Relative Risk - StatPearls - NCBI Bookshelf - NIH
Mar 27, 2023 · Relative risk is a ratio of the probability of an event occurring in the exposed group versus the probability of the event occurring in the non-exposed group.Introduction · Function · Issues of Concern
[51]
History | Framingham Heart Study
The objective of the Framingham Heart Study was to identify the common factors or characteristics that contribute to CVD by following its development over a ...Framingham: Past & Present · Epidemiological Background · Tribute to Dr. DawberMissing: causal inference
[52]
Vaccine Efficacy - an overview | ScienceDirect Topics
Vaccine efficacy is calculated according to the following formula: VE = I u − I v I u × 100 % = 1 − I v I u × 100 % = ( 1 − RR ) × 100 % where: Iu = ...
[53]
The 1964 Report on Smoking and Health - Profiles in Science - NIH
The report estimated that average smokers had a nine- to ten-fold risk of developing lung cancer compared to non-smokers: heavy smokers had at least a twenty- ...
[54]
[PDF] Minimum Wages and Employment: A Case Study of the Fast-Food ...
On April 1, 1992, New Jersey's minimum wage rose from $4.25 to $5.05 per hour. To evaluate the impact of the law we surveyed 410 fast-food restaurants in.
[55]
[PDF] Causal Chains and Mediation Analysis with Instrumental Variables
We use randomization into Job. Corps as instrument for first year program participation (treatment) to disentangle the earnings effect among female compliers in ...
[56]
[PDF] Identification of Causal Effects Using Instrumental Variables
Angrist, Imbens, and Rubin (AIR) apply the method of instrumental variables (IV) to estimate the local average treatment effect (LATE) of Imbens and Angrist ( ...
[57]
[PDF] Statistics and Causal Inference Author(s): Paul W. Holland Source
Problems involving causal inference have dogged at the heels of statistics since its earliest days. Correlation does not imply causation, and yet causal.
[58]
Confounding and Collapsibility in Causal Inference - Project Euclid
Special attention is given to definitions of confounding, problems in control of confound- ing, the relation of confounding to exchangeability and ...
[59]
[PDF] Causal Inference in Observational Studies - Claire Palandri
The OLS estimator will be biased. Sources of endogeneity. • reverse causality or simultaneity: If Y also affects D, that's captured by e, making e correlated ...
[60]
Berkson's bias, selection bias, and missing data - PMC - NIH
Collider bias (or collider-stratification bias, or collider-conditioning bias) is bias resulting from conditioning on a common effect of at least two causes.
[61]
None
### Summary of Ethical Issues in RCTs from the Paper
[62]
The ethics of clinical trials - PMC - PubMed Central - NIH
Jan 16, 2014 · The main ethical issues surrounding RCTs · Participation and informed consent · Use of placebo and deception · Randomisation and blinding, and ...
[63]
https://www.pnas.org/doi/pdf/10.1073/pnas.2008740118
[64]
https://pmc.ncbi.nlm.nih.gov/articles/PMC3894239/
[65]
Causal Inference and Effects of Interventions From Observational ...
May 9, 2024 · We suggest a framework for observational studies that aim to provide evidence about the causal effects of interventions based on 6 core questions.
[66]
https://arxiv.org/pdf/2508.17099.pdf