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Conium maculatum

Conium maculatum, commonly known as poison hemlock, is a highly toxic biennial herbaceous flowering plant in the family Apiaceae, native to Europe, North Africa, and western Asia.^[1] It typically grows 2 to 10 feet (0.6 to 3 meters) tall, featuring smooth, hollow stems marked with distinctive purple spots and ridges, finely divided leaves resembling those of parsley or wild carrot, and clusters of small white flowers arranged in umbels during its second year of growth.^[1]^[2] All parts of the plant, particularly the seeds and roots, contain potent piperidine alkaloids such as coniine and γ-coniceine, which give it a characteristic musty, mouse-like odor and render it one of the most poisonous plants worldwide.^[2]^[3] The toxicity of C. maculatum arises from its alkaloids, which act as neurotoxins by blocking nicotinic acetylcholine receptors, leading to progressive muscle paralysis, respiratory failure, and death if ingested in sufficient quantities.^[4] Symptoms in humans and animals include nausea, vomiting, tremors, and ascending paralysis starting from the extremities, with fatalities occurring within hours in severe cases.^[2] Livestock such as cattle, horses, and goats are particularly vulnerable when grazing in infested areas, and even small amounts— as little as 0.5% of body weight—can be lethal.^[5] The plant's invasive nature in North America, where it was introduced in the 19th century, exacerbates risks in pastures, roadsides, and wetlands, prompting ongoing management efforts to control its spread.^[1]^[6] Historically, Conium maculatum has been infamous for its use in executions and as a medicinal herb, most notably in ancient Greece where it was employed to poison condemned prisoners, including the philosopher Socrates in 399 BCE.^[1] Socrates' death, described by Plato, involved drinking a hemlock infusion that caused paralysis and cessation of breathing, highlighting the plant's lethal potency long before modern toxicology.^[5] In traditional medicine, diluted extracts were used for pain relief, sedation, and treating conditions like spasms, but such applications ceased due to the narrow margin between therapeutic and toxic doses.^[1] Today, C. maculatum is recognized primarily as a noxious weed, with no safe uses, and public health warnings emphasize avoiding contact or consumption to prevent accidental poisoning.^[7]

Description and Identification

Morphology

Conium maculatum is a biennial herbaceous plant that typically grows 0.6 to 3 meters (2 to 10 feet) tall, exhibiting an erect growth habit with branching from the base and remaining glabrous throughout its structure.^[8]^[9] The stems are smooth, hollow, and distinctly marked with purple or reddish blotches, which become more prominent toward the base.^[8] Leaves are alternate, tri-pinnate, and fern-like in appearance, measuring 20 to 40 cm in length with finely divided, toothed segments; they emit a strong musty odor when crushed.^[10]^[11]^[8] The flowers are small, white, and five-petaled, arranged in compound umbels 4 to 8 cm across, which bloom from May to July.^[5]^[12] Fruits are oval schizocarps, 2 to 3 mm long, ridged with wavy margins, and each containing two seeds.^[10]^[13] The roots form a white taproot system that is branched and resembles a parsnip, though it possesses a disagreeable odor.^[14]

Similar species

Conium maculatum is frequently confused with other members of the Apiaceae family due to its fern-like leaves and white umbel inflorescences, but key morphological and ecological differences aid in identification.^[15] Primary look-alikes include wild carrot (Daucus carota), which has a solid, hairy green stem and a carrot-like odor when crushed, contrasting with the smooth, purple-spotted, hollow stem and musty mouse-like odor of C. maculatum; the white taproot of wild carrot also serves as a distinguishing root feature.^[8] Similarly, wild parsnip (Pastinaca sativa) features yellow flowers and deeply lobed leaves with toothed leaflets, along with a sap that causes phytophotodermatitis burns upon skin contact, unlike the white-flowered, finely divided leaves and non-photosensitizing sap of C. maculatum.^[15] Water hemlock (Cicuta spp.), such as Cicuta maculata, shares similar white umbels but grows in wet habitats like streams and ditches, with solid stems often chambered at the base, broader lanceolate leaves with serrated margins, and a carrot-like odor, whereas C. maculatum prefers drier disturbed sites, has hollow stems with purple splotches, finely lacy leaves, and a foul odor; water hemlock is more acutely toxic due to cicutoxin concentrated in its bulbous roots.^[16]^[17] Cow parsley (Anthriscus sylvestris), also known as wild chervil, has finer, coarser leaves with hairs, a green grooved stem lacking purple spots, and less branching, reaching heights of 18 inches to 4 feet compared to the 0.6- to 3-meter (2- to 10-foot) hairless, blotched stems of C. maculatum.^[18]^[8] Distinctive identification markers for C. maculatum include the complete absence of hairs on mature stems and leaves, prominent purple splotches or streaks on the lower stem, and a characteristic foul, mouse-urine-like odor when foliage is crushed, which differentiates it from the hairy or unscented alternatives.^[15]^[18] In North America, C. maculatum is sometimes misidentified with native hemlock trees (Tsuga spp.), such as eastern hemlock (Tsuga canadensis), but the latter is a non-toxic coniferous evergreen tree with needle-like leaves and cones, not an herbaceous biennial forb.^[17]^[19]

Taxonomy

Classification

Conium maculatum belongs to the kingdom Plantae, phylum Tracheophyta, class Magnoliopsida, order Apiales, family Apiaceae, subfamily Apioideae, tribe Selineae, genus Conium, and species C. maculatum.^[20] This placement situates it within the diverse carrot family (Apiaceae), which comprises over 3,700 species characterized by umbellate inflorescences.^[20] Phylogenetically, Conium forms a distinct monotypic clade within the early-diverging lineages of subfamily Apioideae, the largest subfamily of Apiaceae, often referred to as the umbellifer clade.^[21] A 2021 nuclear phylogenomic study using high-throughput sequencing of multiple nuclear loci confirmed the monophyly of the Conium clade, positioning it as sister to the Selineae-Coridandreae alliance in coalescent-based analyses.^[21] Close relatives include genera such as Sium (water parsnip) within the broader Apioideae, though Cicuta (water hemlock) resides in the related tribe Oenantheae.^[22]^[20] The species has several historical synonyms, including Conium divaricatum Boiss. & Orph. (described in 1872) and Conium nodosum Fisch. ex Steud. (proposed in 1821), reflecting reclassifications during the 18th and 19th centuries based on morphological variations in stem branching and fruit structure.^[20]^[23] These names were later consolidated under C. maculatum as the accepted binomial, established by Carl Linnaeus in 1753.^[20] No infraspecific taxa, such as subspecies or varieties, are currently recognized for Conium maculatum in major botanical authorities.^[20] However, studies have documented geographic variation in alkaloid content among populations, with California-sourced plants exhibiting higher levels of coniine and related piperidine alkaloids compared to those from other regions, potentially indicating ecotypic differentiation.^[24]

Names and etymology

The scientific name Conium maculatum originates from classical languages reflecting the plant's characteristics and reputation. The genus name Conium derives from the Ancient Greek word kōneion (κώνειον), an early term for hemlock poison used by the physician Dioscorides in his 1st-century AD work De Materia Medica, possibly linked to konas meaning "to whirl" in reference to the vertigo induced by its toxins.^[25]^[26] The specific epithet maculatum is Latin for "spotted" or "blotched," describing the distinctive purple splotches on the mature stems.^[25]^[1] Common names for Conium maculatum emphasize its toxicity and resemblance to edible plants, including poison hemlock (predominant in North America), spotted hemlock, deadly hemlock, and poison parsley.^[3]^[27] Other variants include poison fool's parsley and spotted parsley, highlighting risks of misidentification with wild carrot or parsnip.^[27] The plant received its formal binomial nomenclature from Carl Linnaeus in his 1753 publication Species Plantarum, marking the first description of the genus Conium.^[20] Earlier references appear in ancient Greek texts, where Dioscorides described it as a potent poison capable of causing paralysis and death, influencing its association with hemlock in classical literature.^[25]^[26] Cultural naming influences stem from historical confusions, particularly in English-speaking regions where "hemlock" originally denoted coniferous trees like Tsuga canadensis, leading to the specifier "poison" for C. maculatum to distinguish the toxic herb.^[17] In the Caucasus region, including Georgia, the plant has been cautiously incorporated into traditional spring foraging practices despite its dangers, though specific local names vary and underscore its dual role in folk botany.^[28]

Distribution and Habitat

Native range

Conium maculatum is native to Europe, North Africa, and western Asia, with its original distribution spanning from the Mediterranean region northward to Scandinavia, across North Africa from Morocco to Egypt, and into temperate Asia extending up to the Himalayas. This geographic range reflects its adaptation to temperate climates where it has established since prehistoric times. Archaeological evidence, including plant remains found in Roman sewer deposits in York, England, confirms its presence in Europe during ancient periods, indicating long-standing indigenous occurrence in the region.^[29]^[30]^[31] In its native habitats, C. maculatum thrives in moist, nitrogen-rich soils within disturbed areas such as riverbanks, ditches, waste grounds, and roadsides, where it often colonizes sites with high nutrient availability from organic matter or runoff. It tolerates partial shade and prefers fertile loamy soils, commonly occurring in low-lying wetlands, floodplains, and edges of woodlands. The plant is less frequent in mountainous regions above 1000 meters elevation, where conditions become drier or more exposed, limiting its abundance compared to lowland populations.^[3]^[32]^[11] The species favors temperate climates with mean annual temperatures between 5°C and 20°C, demonstrating frost tolerance as a biennial that can overwinter in USDA hardiness zones 4-8. It persists in environments with moderate winters and adequate moisture, supporting its post-glacial colonization across Europe following the retreat of ice sheets, as evidenced by its widespread distribution in suitable niches today. Population dynamics show it as a common pioneer in lowland disturbed sites, with densities higher in areas of frequent disturbance and nutrient enrichment.^[33]^[34]

Introduced ranges and invasiveness

Conium maculatum has been introduced to numerous regions outside its native range in Europe, western Asia, and North Africa, primarily through human activities such as ornamental planting and accidental transport. It was first brought to North America in the 1800s, likely as a garden ornamental, and has since become widespread across the continent, including the United States, Canada, and South America.^[25]^[35] The species has also established populations in southern Africa, Australia, New Zealand, and parts of Asia like China, often arriving via contaminated seed or ship ballast.^[33]^[36] In many introduced areas, C. maculatum is considered invasive, particularly in temperate climates where it thrives in disturbed habitats such as roadsides, ditches, and riparian zones. It is classified as a noxious weed in several U.S. states, including California, Ohio, and Washington in the Pacific Northwest, where it is prohibited or restricted due to its aggressive spread and displacement of native vegetation.^[14]^[37]^[38] In riparian areas, it forms dense stands that outcompete and shade out native plants, altering community composition and reducing biodiversity.^[9]^[39] The plant spreads primarily through seed dispersal, with a single mature individual capable of producing 1,500 to 39,000 seeds, approximately 80% of which are viable and can remain dormant in the soil for up to six years.^[33] Seeds typically fall near the parent plant but are secondarily dispersed by water flow in riparian zones, erosion, animals, birds, and human activities like mowing or machinery, facilitating local and regional expansion.^[40]^[41] Ecological impacts include potential allelopathic effects from root exudates and litter, which inhibit germination and growth of nearby native species, further promoting its dominance in invaded ecosystems.^[42]^[43] As of recent assessments, C. maculatum continues to expand in the U.S. Midwest, including states like Ohio and Wisconsin, where warmer temperatures associated with climate change may enhance its germination and establishment.^[14]^[44] It is monitored by the U.S. Department of Agriculture and the U.S. Geological Survey as a nonindigenous species of concern, particularly in aquatic and wetland habitats where it poses risks to native flora.^[3]^[2]

Ecology

Life cycle and growth

Conium maculatum, commonly known as poison hemlock, exhibits a biennial life cycle, completing its development over two years before dying after reproduction. While typically biennial, it can also complete its cycle as a winter annual or short-lived perennial in suitable environments. In the first year, seeds germinate to form a low-growing basal rosette of leaves, which remains vegetative through fall and winter, with rapid growth occurring in early spring under suitable conditions. During the second year, the plant bolts, producing tall, erect stems that reach heights of 6 to 10 feet, followed by flowering, seed production, and senescence.^[45]^[46]^[40] Reproduction in C. maculatum occurs primarily through sexual means via seeds, with individual plants capable of producing 1,700 to 40,000 seeds per plant. The plant is self-incompatible, necessitating outcrossing via pollinators for successful seed set, and seeds exhibit high germination rates of up to 85% under favorable conditions. Seed viability persists in the soil for 3 to 6 years, enabling persistent seed banks that contribute to the plant's invasiveness.^[45]^[46]^[40] Germination typically occurs in late summer to early fall or early spring, requiring moist soil conditions and cool temperatures ranging from 59°F to 86°F, along with approximately 14 hours of daylight; many seeds exhibit morphological dormancy, necessitating cold stratification over winter to break dormancy. Optimal growth favors moist soils with moderate fertility, such as those found in disturbed areas like roadsides, ditches, and streambanks, though established plants can tolerate semi-dry conditions and mature within two years. The plant prefers soil moisture levels supporting consistent hydration during early stages but demonstrates resilience to fluctuating moisture once rooted.^[45]^[40]^[47] Phenologically, in the northern hemisphere, bolting and flowering commence in late spring, typically from May to July, with white umbel inflorescences attracting pollinators. Seed maturation and dispersal follow in August to September, often aided by wind, water, or human activities like mowing, after which the plant dies. Adaptations such as a deep taproot system enhance drought tolerance once established, while cold stratification requirements ensure synchronized germination with seasonal cues, promoting survival in temperate climates.^[46]^[45]^[40]

Biological interactions

Conium maculatum serves as a nectar source for various insect pollinators, primarily flies and bees, which are attracted to its umbellate inflorescences typical of the Apiaceae family. The plant's hermaphroditic flowers facilitate self-fertilization but are predominantly cross-pollinated by these insects, ensuring effective seed production. The pollen contains piperidine alkaloids such as coniine, and the nectar appears less toxic.^[33]^[48]^[49] In terms of herbivory, C. maculatum acts as a larval host for specific insects adapted to its toxicity, including the defoliating moth Agonopterix alstroemeriana (Lepidoptera: Oecophoridae), whose caterpillars feed exclusively on the plant and can cause significant defoliation. Similarly, the black swallowtail butterfly Papilio polyxenes utilizes C. maculatum as a host for its larvae, which sequester alkaloids for defense against predators. Despite these specialist herbivores, the plant's high alkaloid content deters most generalist grazers, limiting broader herbivory by mammals and other insects.^[24]^[50]^[51]^[49] The plant is susceptible to several pathogens, including the rust fungus Puccinia conii, which infects leaves and stems, causing visible pustules and potentially reducing vigor in infected populations. C. maculatum also hosts multiple viruses, such as carrot thin leaf virus, celery mosaic virus, alfalfa mosaic virus, ringspot virus, and cucumber mosaic virus, which can lead to mosaic symptoms, stunting, and decreased seed viability. These pathogens have been explored in biological control trials targeting C. maculatum as an invasive weed, though their efficacy remains limited compared to insect agents.^[52]^[33]^[45] Symbiotically, C. maculatum forms associations with arbuscular mycorrhizal fungi (AMF) from the Glomeromycota phylum, which colonize its roots and enhance nutrient uptake, particularly phosphorus and other minerals, in nutrient-poor or heavy metal-contaminated soils. These mutualistic relationships improve plant establishment and growth by extending the root system's absorptive capacity through fungal hyphae, providing a competitive advantage in marginal habitats.^[53] Competitively, C. maculatum exhibits allelopathic effects through the release of water-soluble compounds from its tissues, which inhibit seed germination and root elongation of neighboring plants, including native species and crops. Leachates from fresh plant material, at concentrations as low as 10%, have demonstrated significant suppression of germination in test species such as lettuce and grasses, contributing to the plant's invasiveness by reducing biodiversity in affected areas.^[42]^[54]

Management and control

Prevention of Conium maculatum infestations focuses on minimizing soil disturbance, which facilitates seed germination, and regular monitoring of waterways and moist areas for early detection of small populations.^[55] Early intervention is critical, as the plant can rapidly spread in disturbed habitats like riverbanks and roadsides.^[56] Mechanical control methods are suitable for small infestations and include hand-pulling or digging to remove the entire taproot, ideally before the plant bolts and seeds in late spring or early summer; protective gloves should be worn to avoid skin irritation from plant sap.^[40] Repeated mowing or cutting close to the ground over multiple seasons can exhaust the root reserves and prevent seed production, though single mowings may promote resprouting.^[57]^[58] Chemical control relies on herbicides applied during the rosette stage in fall or early spring for optimal efficacy, when plants are actively growing but before bolting. Broadleaf-selective herbicides such as 2,4-D (at rates of 1.5 lb ae/A) or non-selective glyphosate (mixed to 2% solution) effectively target C. maculatum, with post-flowering applications helping to suppress seed set; these should be spot-treated to minimize impact on surrounding vegetation.^[40]^[59]^[60] Adding wetting agents can enhance herbicide uptake, and tank mixes with dicamba may improve control in certain settings.^[61] Biological control options include the poison hemlock moth (Agonopterix alstroemeriana), approved by the USDA for release against C. maculatum in the United States, where its larvae defoliate and weaken plants during the rosette and bolting stages.^[55] Rust fungi have been explored as potential agents but are not yet widely established for this weed; integrated pest management (IPM) approaches combine these with mechanical and chemical methods for sustainable long-term suppression.^[33]^[62] Recent guidelines from the USDA Forest Service emphasize early detection and integrated management, particularly in wetland and riparian zones where C. maculatum thrives as an invasive species.^[56] In states like Washington, it is classified as a Class B noxious weed, requiring control on public lands and prevention of further spread.^[57]

Phytochemistry

Alkaloids

The primary toxic alkaloids in Conium maculatum are piperidine derivatives, with coniine (C₈H₁₇N) being the most abundant and well-known, existing as a volatile, colorless liquid with a characteristic mousy odor.^[63] Other key alkaloids include γ-coniceine (C₈H₁₅N), the biosynthetic precursor to coniine, as well as N-methylconiine and conhydrine.^[63] Coniine features a 2-propylpiperidine structure with a stereocenter at the C-2 position, where the naturally occurring (S)-(+)-enantiomer predominates, while γ-coniceine is an unsaturated analog, 2-propyl-1,4,5,6-tetrahydropyridine.^[63] Alkaloid concentrations vary significantly across plant parts and developmental stages, with the highest levels in fruits and seeds, reaching up to 3% of dry weight during early fruit development (around week 3 post-fertilization), primarily as coniine and N-methylconiine.^[63] In contrast, leaves contain lower amounts, typically 0.1-0.5% dry weight, dominated by γ-coniceine in young tissues.^[64] Factors such as plant age, seasonal conditions, and environmental stress influence these levels; for instance, γ-coniceine predominates during rainy periods and peaks midday, while coniine increases under drier conditions, with diurnal fluctuations exceeding 100%.^[63] Biosynthesis of coniine begins with the condensation of butyryl-CoA and two malonyl-CoA units by a type III polyketide synthase (CPKS5), forming a triketide intermediate that is reduced by polyketide reductase (PKR) to 5-keto-octanal.^[65] Nitrogen incorporation occurs via L-alanine:5-keto-octanal aminotransferase (AAT), leading to non-enzymatic cyclization to γ-coniceine, which is then reduced by NADPH-dependent γ-coniceine reductase (CR) to yield coniine; further methylation by S-adenosyl-L-methionine:coniine methyltransferase (CSAM) produces N-methylconiine.^[65] A 2022 de novo transcriptome analysis of C. maculatum identified candidate genes for these enzymes, including two for CPKS5, two for PKR, six for AAT, seven for CR, and nine for CSAM, confirming the polyketide origin rather than a lysine-derived pathway.^[65] Quantification of these alkaloids typically employs gas chromatography-mass spectrometry (GC-MS), which separates and identifies compounds based on retention times and mass spectra, enabling precise measurement in plant extracts.^[24] This method has been widely used to profile alkaloid profiles across C. maculatum tissues, revealing four major alkaloids: coniine, γ-coniceine, conhydrinone, and an unidentified minor one.^[24]

Other compounds

Conium maculatum produces a range of non-alkaloid secondary metabolites that support plant defense against herbivores and pathogens, as well as potential bioactivities such as antioxidant effects. Flavonoids, including glycosides of quercetin and kaempferol, predominate in the leaves and exhibit antioxidant properties by scavenging free radicals and reducing oxidative stress.^[66] These compounds contribute to the plant's resilience in varying environmental conditions, though their concentrations remain relatively low compared to toxic alkaloids.^[67] Polyacetylenes, notably falcarinol and falcarindiol, are concentrated in the roots and serve as antimicrobial agents, with falcarinol known to induce skin irritation and allergic contact dermatitis upon handling the plant. Falcarinol levels average 9.0 mg/kg dry matter (ranging from 0 to 248.8 mg/kg), while falcarindiol is more abundant at 328.8 mg/kg dry matter (ranging from 0 to 1570.2 mg/kg), showing high variability across plant accessions analyzed via gas chromatography-mass spectrometry.^[68] Stress factors, such as elicitors like alginic acid or fungal extracts, elevate polyacetylene production, enhancing antifungal defenses as demonstrated in cell culture studies.^[69] The plant's essential oils, derived mainly from fruits and leaves, impart its characteristic odor and include phenylpropanoids, with minor furanocoumarins like psoralen and bergapten contributing to phototoxic and antimicrobial roles.^[70] Furanocoumarin levels in roots are comparable to those in related Apiaceae species, such as parsnip, and increase under stress via biosynthetic upregulation.^[68] Nutritionally, Conium maculatum contains low levels of vitamins C and K, primarily in aerial parts, but these are overshadowed by the dominant defensive compounds.^[67] Recent high-performance liquid chromatography analyses confirm elevated polyacetylene content in stressed specimens, underscoring environmental influences on phytochemical profiles.^[71]

Toxicity

Effects on humans

Conium maculatum exerts its toxic effects on humans primarily through its piperidine alkaloids, particularly coniine, which acts as an agonist at nicotinic acetylcholine receptors in the peripheral nervous system. This binding initially stimulates the receptors, leading to enhanced cholinergic activity, but prolonged exposure causes persistent depolarization and subsequent blockade, resulting in ascending flaccid paralysis that begins in the extremities and progresses upward. The primary exposure route is ingestion, often due to misidentification of the plant as edible species like wild parsley or parsnip during foraging activities. Dermal contact with the plant's sap can cause skin irritation, hyperpigmentation, or blisters attributed to polyacetylenes such as falcarinol, while inhalation of dust or volatile compounds from the plant is rare but can cause severe systemic toxicity, including respiratory failure and coma, as reported in a 2025 case involving exposure during mowing.^[72]^[73]^[74]^[3]^[68]^[75] Symptoms of poisoning typically manifest within 30 minutes to 3 hours after ingestion, beginning with gastrointestinal distress including nausea, vomiting, and abdominal burning, accompanied by neurological signs such as tremors, excessive salivation, dilated pupils, and muscle pain or twitching. As the toxicity progresses, victims experience increasing muscle weakness, ataxia, hypertension, rapid heartbeat, and restlessness, leading to profound paralysis of the limbs and trunk. Respiratory failure ensues as the diaphragm and intercostal muscles become paralyzed, culminating in asphyxiation and death, which can occur 2-6 hours after consuming a lethal dose if untreated. In June 2025, a man in Ohio suffered severe poisoning, including coma and respiratory failure, after inhaling poison hemlock particles while mowing an infested area, underscoring inhalation risks.^[76]^[77]^[78]^[79]^[75] The lethal dose of coniine for a 70 kg adult is estimated at 150-300 mg, roughly equivalent to the alkaloids in 6-8 fresh leaves (about 6 g of plant material) or 0.5-1 g of seeds, depending on alkaloid concentration which varies by plant part and growth stage. Historically, the most notorious case is the execution of the philosopher Socrates in 399 BCE, who was forced to drink a hemlock infusion containing coniine, leading to his death by progressive paralysis and respiratory arrest as described in Plato's Phaedo. In modern times, poisoning incidents continue to arise from foraging errors, such as a 2017 case in the United States where a couple misidentified poison hemlock as wild celery, resulting in severe symptoms including respiratory arrest in one victim, though both survived with medical intervention.^[80]^[63]^[81]^[74]

Effects on animals

Conium maculatum, commonly known as poison hemlock, poses significant toxicity risks to livestock, particularly cattle and sheep, which are highly susceptible due to their grazing habits in infested areas. Ingestion of as little as 0.2–0.5% of an animal's body weight in green plant material can prove fatal, equivalent to approximately 100–500 g for sheep (depending on size) or 1–3 kg for adult cattle.^[2]^[40] Symptoms typically manifest within 15 minutes to two hours and include excessive salivation, nervousness, tremors, muscular weakness, ataxia, and respiratory paralysis leading to death.^[82]^[83] The primary toxic agent, coniine, has a lethal dose in sheep of approximately 240 mg/kg body weight, highlighting the plant's potency even in small quantities.^[84] In addition to acute poisoning, chronic or sublethal exposure during pregnancy results in teratogenic effects, causing congenital defects such as crooked limbs, cleft palate, and skeletal malformations in offspring. These defects occur when pregnant cattle or sheep consume the plant between days 40 and 100 of gestation, with cattle showing higher sensitivity than sheep.^[85]^[63] Poison hemlock contributes to substantial economic losses in the livestock industry, estimated at over $100 million annually in the United States from poisonous plant toxicoses, including fatalities and reduced productivity.^[86] Recent reports from 2024 indicate heightened concerns in invasive regions, with university extension services documenting increased livestock poisoning cases amid expanding plant populations along roadsides and waterways.^[87] Wildlife exhibits varied responses to poison hemlock, with some species demonstrating tolerance that mitigates broader ecological impacts. Birds, such as finches, often consume the plant's seeds without apparent harm, likely due to rapid metabolism of the alkaloids, allowing them to serve as dispersers rather than victims.^[88] In contrast, certain insects, including black swallowtail caterpillars (Papilio polyxenes), feed on the foliage and sequester piperidine alkaloids like coniine for their own defense against predators, enhancing their survival in hemlock-dominated habitats.^[89]^[90] Domestic pets, including dogs and cats, face similar risks to humans from accidental ingestion, particularly in gardens or yards where poison hemlock invades. Symptoms mirror those in livestock, encompassing agitation, tremors, drooling, diarrhea, and potential respiratory failure, with poisoning often reported from curious exploratory behavior.^[91]^[92] Veterinary cases underscore the need for prompt identification and removal of the plant from pet-accessible areas to prevent these incidents.^[93]

Treatment of poisoning

Treatment of Conium maculatum poisoning primarily involves supportive care, as no specific antidote exists.^[80] Immediate decontamination is critical if ingestion is recent; for conscious patients, inducing vomiting or performing gastric lavage within one hour, followed by administration of activated charcoal (typically 1 g/kg), can help adsorb alkaloids and reduce absorption.^[80]^[94] Supportive measures address the progression of symptoms, such as respiratory muscle paralysis leading to failure, with mechanical ventilation essential for severe cases to maintain oxygenation.^[95] Atropine (0.5–1 mg IV, repeatable) may be used to manage bradycardia or nicotinic signs like salivation and tremors, though its efficacy is limited by the primarily nicotinic mechanism of the alkaloids and remains somewhat controversial in guidelines.^[96]^[97] Physostigmine has been explored in experimental settings for counteracting central nervous system effects but is not a standard treatment due to risks like seizures and lack of broad clinical validation.^[98] Patients require close monitoring in an intensive care setting for complications including rhabdomyolysis, seizures, or renal failure, with intravenous fluids and antiseizure medications (e.g., benzodiazepines) as needed.^[96]^[94] In veterinary medicine, treatment mirrors human protocols but adapts to species-specific needs. Activated charcoal (2–3 g/kg orally, multiple doses) is administered early to bind toxins, often combined with a cathartic like magnesium sulfate, while intravenous fluids support hydration and renal function.^[2]^[99] Atropine is used for bradycardia or excessive salivation in affected animals such as cattle, horses, or goats, and mechanical ventilation may be required for respiratory distress.^[100] For pregnant livestock, particularly cows exposed during early gestation, monitoring for teratogenic effects like skeletal deformities (e.g., crooked calf syndrome) is crucial, with ultrasound or veterinary follow-up recommended, though no direct reversal exists.^[2] Prevention focuses on public and agricultural education to distinguish Conium maculatum from edible plants like wild carrot. According to 2025 updates from poison control resources, rapid hospitalization is emphasized for any suspected exposure, with immediate contact to centers like the American Association of Poison Control Centers (1-800-222-1222) advised to guide decontamination and transport.^[101]^[74]

Cultural Significance

Historical uses

In ancient Greece and Rome, Conium maculatum was employed both as a medicinal agent and an execution tool. The plant served as a sedative for treating spasms and gout, as documented by the physician Pedanius Dioscorides in his 1st-century CE work De Materia Medica, where he described its use in small doses for these conditions while warning of its potent toxicity.^[102] In Athens, extracts of the plant were used to execute condemned prisoners, most famously the philosopher Socrates in 399 BCE, who consumed a hemlock-based poison as his death sentence, leading to progressive paralysis and respiratory failure.^[25] Roman physicians like Aulus Cornelius Celsus and Galen similarly recognized its dual role, prescribing controlled applications for pain relief and muscle relaxation but prohibiting its unregulated use under laws such as the Lex Cornelia de sicariis et veneficis (81 BCE), which criminalized poisonous substances.^[102] During the medieval period in Europe, Conium maculatum featured in herbal remedies derived from classical texts, often as tinctures or mixtures for respiratory and spasmodic ailments. It was applied as an antispasmodic for conditions including asthma, whooping cough, epilepsy, and angina, with preparations like the anesthetic "dwale" (combining hemlock, henbane, opium, and wine) used by surgeons to induce sleep during procedures.^[63] These uses persisted in monastic physic gardens and apothecary practices, where the plant's sedative properties were valued despite risks, and tinctures remained in European pharmacopeias for such applications until the 19th century.^[103] A mixture of hemlock and henbane was specifically recommended for aching joints, reflecting its integration into humoral medicine for balancing bodily "colds."^[104] In the 19th and 20th centuries, Conium maculatum found a niche in homeopathic medicine, where highly diluted preparations were used to treat neuralgia, vertigo, and glandular swellings. Samuel Hahnemann, founder of homeopathy, introduced it in the early 1800s for conditions like sciatic pain and nerve-related disorders, based on provings that highlighted its effects on sensory and motor functions.^[105] A 2023 study on homeopathic dilutions of Conium maculatum (6CH and 200CH) demonstrated cytotoxic effects on MCF-7 breast cancer cells via MTT and sulforhodamine B assays, reducing viability by up to approximately 80% at 100 μl concentrations.^[106] However, its association with Socrates' poisoning and documented toxicity led to bans or strict regulations in many countries, including restrictions on non-homeopathic extracts in the United States and Europe by the mid-19th century, limiting its practical applications.^[103] Recent research has explored Conium maculatum's potential anti-cancer properties, particularly through its alkaloids like coniine and analogs such as conhydrine and pseudoconhydrine. A 2023 in silico study identified these compounds as potential epidermal growth factor receptor (EGFR) inhibitors for metastatic colorectal cancer, with docking affinities ranging from -5.2 to -5.6 kcal/mol and favorable pharmacokinetics, suggesting apoptosis induction without predicted toxicity in models.^[107] Despite these findings, therapeutic approval remains elusive due to the plant's narrow therapeutic index and high risk of systemic poisoning, confining investigations to in vitro and preclinical stages.^[63]

In literature and symbolism

Conium maculatum, commonly known as poison hemlock, holds a prominent place in Greek mythology as the agent of enforced suicide, most famously depicted in Plato's Phaedo, where it is used to execute the philosopher Socrates in 399 BCE. In this dialogue, Socrates calmly drinks the hemlock potion amid philosophical discourse on the soul's immortality, portraying the plant as a symbol of stoic acceptance in the face of unjust death.^[108] In literature, poison hemlock appears as a motif of malevolence and supernatural peril, notably in William Shakespeare's Macbeth (1606), where the witches' brew includes "root of hemlock digg'd i' the dark" to conjure chaos and ambition-driven treachery.^[109] This reference draws on the plant's historical notoriety as a lethal poison, evoking themes of moral corruption and inevitable downfall. During the Victorian era, hemlock frequently symbolized betrayal and hidden danger in novels and poetry, often representing the insidious nature of deceit, as seen in its use to underscore themes of treachery in works exploring social hypocrisy.^[110] Symbolically, in the Victorian language of flowers or floriography, hemlock denotes "you will be my death," embodying toxicity, peril, and ill fortune, a meaning rooted in its deadly alkaloids and historical associations with execution.^[111] This ominous connotation extended to broader cultural views of the plant as a harbinger of bad luck and mortality, occasionally referenced in funeral contexts to evoke the finality of death, though not as a literal wreath material. In art, poison hemlock features in detailed 18th- and 19th-century botanical illustrations, such as William Curtis's engraving in Flora Londinensis (1796), which captures its umbel-inflorescences and spotted stems to educate on its hazardous beauty amid scientific curiosity.^[112] Modern artistic depictions, including watercolor studies like Marta Bowerley's Poison Hemlock (contemporary), highlight its invasive spread and ecological threat, transforming the plant into a commentary on environmental disruption and human negligence.^[113] In contemporary media, poison hemlock inspires cautionary tales of accidental poisoning from misidentification with edible plants, reinforcing its role as a symbol of nature's deceptive dangers in true-crime documentaries and environmental alerts.

References

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Exotic Species: Poison Hemlock (U.S. National Park Service)
Apr 29, 2016 · Poison hemlock is a highly toxic biennial with the musty, unpleasant odor associated with alkaloids. It grows two to ten feet tall.
[2]
Poison Hemlock (Conium maculatum) - USDA ARS
Jun 26, 2018 · Poison-hemlock has white flowers that grow in small erect clusters. Each flower develops into a green, deeply ridged fruit that contains several ...
[3]
Conium maculatum - Nonindigenous Aquatic Species - USGS.gov
It has leaves and white flowerheads resembling those of parsnips, carrots, and water hemlock. All parts of poison hemlock are poisonous. The long, fleshy, white ...
[4]
Hemlock - Guide to Poisonous Plants
Botanical Name: Conium maculatum L. ... Description Poison hemlock is a coarse, erect, 4-6 feet tall biennial or perennial plant. The smooth, branching stems are ...
[5]
Poison hemlock | Integrated Crop Management - Iowa State University
May 1, 2020 · Poison hemlock Conium maculatum L. General description: Basal rosette during first year and then erect flower stalk 6 to 8 ft tall. Leaves are ...
[6]
Poison Hemlock | USU
A forb, native to Europe, growing 5 to 10 feet tall. Stems are erect, stout, and purple-spotted with distinct ridges and extensively branched.
[7]
Poison Hemlock - Washington Invasive Species Council
Poison hemlock (Conium maculatum) is an acutely toxic plant that, if ingested, can kill humans and animals within a few hours. It is found in many areas ...<|control11|><|separator|>
[8]
Poison hemlock identification and control - King County, Washington
Poison hemlock has red/purple spotted, hollow stems, fern-like leaves with toothed edges, and a musty odor. It has a smooth, hairless stem and emerges early.Giant hogweed · Queen Anne's Lace/Wild Carrot · Rough chervil
[9]
Conium maculatum | UC Irvine
Scientific Name: Conium maculatum. Common Name: Poison Hemlock Photo: Line Drawing: Morphological Description: Grows between 1.5-2.5 meters (3-8 ft) tall
[10]
Conium maculatum (Poison Hemlock) - Minnesota Wildflowers
Leaves are alternate, 2 to 4 times compound, up to 16 inches (20 to 40 cm) long and wide, generally triangular in outline, becoming smaller as they ascend the ...
[11]
Poison Hemlock (Conium maculatum) - Illinois Wildflowers
The alternate leaves are up to 18" long and 12" across, becoming smaller as they ascend the stems. They are double or triple pinnately compound, triangular- ...<|control11|><|separator|>
[12]
Poison Hemlock | Minnesota Department of Agriculture
Leaves are pinnately compound and fernlike. A plant with fernlike leaves in front of a group of shrubs. Poison hemlock is a biennial herbaceous plant. Closeup ...Missing: size | Show results with:size
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Conium maculatum (poison-hemlock) - Go Botany - Native Plant Trust
Leaves ; Bracteole length: 1.5–3 mm ; Bracteole number (Apiaceae): 3–6 ; Bracteole shape: the bracteoles are ovate (widest below the middle, and broadly tapering ...
[14]
Conium maculatum - Nonindigenous Aquatic Species - USGS.gov
Whole upper leaves are sessile. The lower leaf blades are 15-30 cm long and are petioled. All leaves have prominent veins on the undersides. The flowers are ...
[15]
The Parsley Family Identification Guide - Ohioline
Oct 29, 2021 · Shown here are photos and key characteristics for five of the most common weeds: wild carrot (Daucus carota), poison hemlock (Conium maculatum), wild parsnip ( ...
[16]
Poison hemlock identification and control - Agriculture
Apr 20, 2023 · Root smells like carrot; 1-2 feet tall at maturity; Flowers July through September; White, delicate, “umbrella-like” flowers ...
[17]
Poison Hemlock in Alabama - Alabama Cooperative Extension System
May 17, 2024 · Stems may be solid green or purple or have purple streaking or mottling similar to poison hemlock. The leaves are notably different, with larger ...Missing: features | Show results with:features
[18]
Is it Poison Hemlock or Wild Chervil? - Penn State Extension
Apr 16, 2024 · Characteristics · Both have fern-like, glossy green, lacy leaves in the rosette stage and can be difficult to distinguish from each other.
[19]
Some poisonous plants of Tennessee - Bioimages
Poison hemlock should not be confused with the tree, eastern hemlock (Tsuga canadensis) which is relatively harmless. Eastern hemlock is a dominant tree in ...
[20]
Conium maculatum L. | Plants of the World Online | Kew Science
Classification ; Kingdom Plantae ; Phylum Streptophyta ; Class Equisetopsida ; Subclass Magnoliidae ; Order. Apiales. View Order Tree opens in a new tab.
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A higher‐level nuclear phylogenomic study of the carrot family ...
Jul 21, 2021 · In contrast, it also includes notorious toxic species such as hemlock (Conium maculatum) and giant hogweed (Heracleum mantegazzianum).
[22]
Cicuta L. | Plants of the World Online | Kew Science
Cicuta L. is a genus native to the Subarctic & Temp. Northern Hemisphere, with 4 accepted species, and belongs to the Apiaceae family.
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Conium maculatum L. - The Plant List
Synonyms: ; Conium cicuta (Crantz) Neck. Synonym, M ; Conium croaticum Waldst. & Kit. ex Willd. Synonym, M ; Conium divaricatum Boiss. & Orph. Synonym, M ; Conium ...
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Geographic Variation in Alkaloid Production in Conium maculatum ...
Jul 21, 2005 · We found a total of four alkaloids in C. maculatum foliage: coniine, γ-coniceine, conhydrinone, and an unknown alkaloid (RT 12) (Table 1). Not ...Missing: varieties | Show results with:varieties
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[PDF] Poison-Hemlock (Conium maculatum L.)1 - UC ANR Portal
All parts of C. maculatum have long been recognized as being highly poisonous; it was the plant used to kill Socrates in BC 399 (Gledhill 1985; Holm et al.
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Conium - Jepson Herbarium - University of California, Berkeley
Etymology: (Greek name used by Dioscorides) Toxicity: TOXIC: highly toxic ... Next taxon: Conium maculatum. Name Search: Please use this Google Form for ...Missing: reference | Show results with:reference
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Conium maculatum (Deadly Hemlock, Poison Fool's Parsley, Poison ...
The leaves of poison hemlock resemble parsley. The roots, leaves and stems have a foul odor when crushed. It is found growing in disturbed areas, at ...
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[PDF] Edible wild herbs and mushrooms of Tusheti (the eastern Greater ...
Nov 29, 2024 · ) Boriss., Conium maculatum L. [although a poisonous plant], Carum carvi, etc. (Bakhtadze & Koghuashvili 2009, Jikia 1967, 1991 ...
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poison hemlock (Conium maculatum L.) - EDDMapS
Flowers are produced in spring through summer in umbels 3 in (7½ cm) across. Each umbel is further divided into umbellets, each with approximately 15 flowers ...
[30]
Conium maculatum - NatureServe Explorer
Although having the common name 'poison hemlock', this plant is a member of the parsley family (Apiaceae or Umbelliferae) and not a conifer, as are the true ...
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[PDF] The Environmental Evidence from the Church Street Roman Sewer
The archaeological evidence is therefore inconclusive. Other aspects of the ... Conium maculatum L. hemlock medicine. Fragaria vesca L. strawberry food.
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Poison Hemlock | Mississippi State University Extension Service
Poison hemlock has a pungent odor that deters fresh consumption by most livestock; however, contamination of hay is a major concern (Mitich 1998; USDA 2016 ...
[33]
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Conium divaricatum Boiss. & Orph. Conium leiocarpum (Boiss.) Stapf: Conium ... similar to basal, but shortly petiolate and 1-3-pinnate. Umbels 1-8 cm in ...<|control11|><|separator|>
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Conium maculat Hemlock, Poison hemlock PFAF Plant Database
Conium maculat is a BIENNIAL growing to 2 m (6ft) by 1 m (3ft 3in). See above for USDA hardiness. It is hardy to UK zone 5 and is not frost tender.
[35]
Conium maculatum L. - idseed - Seed Identification Guide
Flowers are white, 2mm in diameter, with 5 notched petals that are arranged in umbels (CABI 2022). Vegetative Features. Erect, hollow, ribbed stems may reach ...
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Oct 16, 2017 · Introduced to North and South America, southern Africa, Australia, New Zealand and Micronesia ( USDA - ARS 2016). Duration of ...
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Poison hemlock (Conium maculatum) is a member of the carrot family. It ... throughout the United States, Canada, Australia, New Zealand, and South America
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maculatum; right, blooming umbels of C. maculatum, all images WSNWCB ... to 2.5 feet in diameter. Flattened, elliptical fruit with brown resin canals.
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Overview. Appearance: Conium maculatum, Poison-Hemlock is a biennial herbaceous plant in the carrot family (Apiaceae) that grows 3-8 ft. (0.9-2.4 m) tall.
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It can also invade native plant communities in riparian woodlands, floodplains of natural aquatic systems, and grazing areas, particularly pastures and meadows.Missing: habitat preferences
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[PDF] Poison Hemlock (Conium maculatum) - King County
Rapid growth from March to May, flowers in late spring. Up to 40,000 seeds per plant are produced. Seeds fall near the plant and are moved by erosion, animals, ...
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[PDF] Potentially Allelopathic Effects of Poison Hemlock
Bioassay results of potential allelochemical effects of C. maculatum on itself are inconclusive at this point and require further study.
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"The alleopathic potential of Conium Maculatum" by Janet Andrew
The alleopathic potential of Conium Maculatum ; Publication Date. 2001 ; Degree Type. Thesis ; Degree Name. Master of Science (MS) ; Department. Environmental ...
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[PDF] NAME OF SPECIES: Conium maculatum L. - Wisconsin DNR
3. Geographic Range: Herbarium records exist from 6 counties in Wisconsin (1). Reported mostly in 12 sites in 8 counties 4. Habitat Invaded: Moist, full sun to ...
[45]
Poison Hemlock - WVU Extension - West Virginia University
Jul 14, 2022 · All parts of the plant contain certain alkaloids, which are the toxic components, and for poison hemlock, the two principal ones are coniine and ...
[46]
Poison Hemlock: TOO LATE! - BYGL (osu.edu)
Jun 17, 2022 · Mowing after seeds are produced is a good recipe for spreading poison hemlock. The small seeds can easily hitchhike on mowing equipment, ...Missing: invasiveness | Show results with:invasiveness
[47]
[PDF] Field Guide for the Biological Control of Weeds in Eastern North ...
Poison hemlock, Conium maculatum ... Resolving cryptic species with morphology and DNA; thrips as a potential biocontrol agent of Brazilian peppertree ...
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Conium maculatum L., Hemlock - Fermanagh Species Accounts
C. maculatum originated in the Mediterranean region and W Asia, but has certainly been introduced far beyond its natural range in N Europe and many other ...
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Review Poison hemlock (Conium maculatum L.) - ScienceDirect.com
It is a very common nitrophile weed species, belonging to the Apiaceae (formerly Umbelliferae) family. It contains some piperidine alkaloids (coniine, N-methyl- ...
[50]
Laboratory Rearing of Agonopterix alstroemeriana, the Defoliating ...
Jun 1, 2006 · Conium maculatum L. (Apiaceae), or poison hemlock, is an invasive plant native to Europe that has become extensively naturalized throughout ...
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[PDF] T ni performance - ddd-UAB
little herbivory after invading a new habitat is Conium maculatum (poison hemlock), a ... Papilio polyxenes ... herbivory by Agonopterix alstroemeriana. J. Chem ...<|separator|>
[52]
Conium maculatum (poison hemlock) - ResearchGate
Aug 7, 2025 · Another widespread rust was Puccinia conii on Conium maculatum, that was known as a member of the mycoflora of this area 180 years ago. View.
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Arbuscular mycorrhizal fungi in heavy metal highly polluted soil in ...
... Conium maculatum and Juncus pallescens. Roots of herbaceous mycorrhizal plants were sampled to evaluate their mycorrhizal status. They were cleared in KOH ...
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[PDF] poison hemlock, Conium maculatum
This disease can have devastating effects on crops, and is particularly prominent in the vineyards of California (Hillman, 1997). Certain crops such as alfalfa ...
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[PDF] Field Guide for Managing Poison Hemlock in the Southwest
A selective granular herbicide for use on noncropland, rights-of-way, non-irrigation ditch banks, natural areas, and grazed areas in and around these sites.
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[PDF] Field Guide for Managing Poison Hemlock in the Southwest
Management. Early detection and management of small populations before they can expand into larger populations is extremely important for poison hemlock control ...<|separator|>
[57]
Poison Hemlock - Washington State Noxious Weed Control Board
Mechanical Control. Digging up small infestations and removing the entire taproot is effective. Mowing is ineffective as plants will re-sprout, sending up new ...
[58]
Poison hemlock | (Conium maculatum) - Wisconsin DNR
Leaf veins end at the tips of the tooth margins. Leaves are shiny, green and emit an unpleasant odor when crushed.
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Poison hemlock 2,4-D or MCPA. Rate 1.5 lb ae/A. Time Apply in seedling to rosette stage of growth. Remarks Most effective soon after plants emerge.
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[PDF] Control Options for Poison Hemlock
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Conium maculatum L. Poison-hemlock. Family: Apiaceae. Range: Throughout the contiguous U.S., including every western state.
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Poison hemlock, or Conium maculatum, contain piperdine alkaloids such as coniine that cause disruptions to the central nervous system.
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[PDF] Poison Hemlock Toxicity in Goats and Sheep
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A mixture of henbane and hemlock was applied to aching joints. Coriander was used to reduce fever. Stomach pains and sickness were treated with wormwood, mint, ...
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Conium maculatum - Wikipedia
Under the right conditions, the plant grows quite rapidly during the growing season and can reach heights of 2.4 metres (8 feet) with a long penetrating root.Coniine · Impiety · Anthriscus sylvestris · Cicuta
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CONIUM MACULATUM - HOMOEOPATHIC MATERIA MEDICA
CONIUM MACULATUM Poison Hemlock (CONIUM). An old remedy, rendered classical by Plato's graphic description of its employment in the death of Socrates. The ...Missing: neuralgia | Show results with:neuralgia
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Identification of Potential Phytochemical Inhibitors From Conium ...
Oct 30, 2023 · C. maculatum extracts have been demonstrated in many studies to exhibit anticancer activity in multiple kinds of cancer and have the potential ...
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[PDF] Anti-Cancer Activity of Conium Maculatum in MCF-7 ... - Pubtexto
Aug 23, 2023 · The present study examined the effects of Conium Maculatum in breast cancer cells by using MTT Assay, SBB Assay and cell proliferation assay ...
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Plato, Phaedo, trans. Jowett - The Center for Hellenic Studies
[57a] Were you yourself, Phaedo, in the prison with Socrates on the day when he drank the poison [pharmakon]?. Phaedo. I myself was there, Echecrates.Missing: hemlock | Show results with:hemlock
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The Poisons, Potions, and Charms of Shakespeare's Plays
Apr 5, 2016 · While some of the components are outlandish, hemlock was a poison well-known in herbals, the “digged i'th' dark” emphasizing, as Petersen ...
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There's Rue for You: A Guide to Victorian Flower Language
Apr 19, 2022 · Hemlock. Decorative Illustration from Flora Symbolica. The “I appreciate our friendship” Bundle: for those who, like the Greeks ...
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A Writers Guide to Poison Hemlock - H. R. Sinclair
May 16, 2016 · Conium (the genus name) comes from the Greek konas meaning to whirl, which references vertigo, one of the symptoms of ingesting the plant.
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Conium maculatum - PALNI Digital Collections
Herbals--18th century · Botanical illustrations. Common name, Poison hemlock. Botanical name, Conium maculatum. Personal name, Curtis, William, 1746-1799
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Poison Hemlock by Marta Bowerley | Annex Galleries Fine Prints
In this watercolor sketch she depicts a stem of poison hemlock, the dangerous, if beautiful, member of the carrot family native to Europe and North Africa.
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Sully Island: Foragers rescued after potentially eating hemlock - BBC
May 13, 2025 · A pair of experienced foragers had to be rescued from an island after potentially eating poisonous hemlock, coastguards have said.Missing: 2020s | Show results with:2020s<|control11|><|separator|>