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References
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Continuous Flow ManufacturingThis is the opposite of batch production. Synonyms include: continuous manufacturing, continuous processing, continuous production, and continuous flow process.
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None### Summary of Continuous Production Systems
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[PDF] Q13 Continuous Manufacturing of Drug Substances and Drug ... - FDAFigure 1 illustrates a drug substance manufacturing process containing both continuous and batch operations. It is not intended to represent a regulatory ...
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Review: Continuous Manufacturing of Small Molecule Solid Oral ...Aug 22, 2021 · Continuous manufacturing (CM) is defined as a process in which the input material(s) are continuously fed into and transformed, and the ...
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[PDF] Control Systems Engineering in Continuous Pharmaceutical ... - MITSteady-State and Dynamics in Continuous Manufacturing In the chemical engineering field, steady state refers to oper- ations in which none of the variables in ...Missing: interruptions | Show results with:interruptions
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[PDF] Primary Metal ProductionBlast furnaces are operated continuously without shutdown for ten years or more. If the furnace were allowed to cool, thermal stresses can cause damage to the ...
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[PDF] EPA Pollution Effects of Abnormal Operations in Iron and Steel MakingThe blast furnace usually operates continuously for 3 to 5 years, after which it is shut down for relining with refractory and for effecting major repairs.
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[PDF] CLASSIFICATION OF PRODUCTION SYSTEMSContinuous Production is characterized by. 1. Dedicated plant and equipment with zero flexibility. 2. Material handling is fully automated. 3. Process follows a ...
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Batch, flow, continuous and custom production processesJul 12, 2024 · Features of continuous production · Has the highest level of capacity utilization · Low unit costs due to a high volume of production · Used in ...<|separator|>
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OEE (Overall Equipment Effectiveness) - Lean ManufacturingOEE (Overall Equipment Effectiveness) is a “best practices” metric that identifies the percentage of planned production time that is truly productive.
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5 reasons to adopt continuous processing in pharmaceutical ... - WSPJun 23, 2025 · Five benefits of continuous processing · 1. It reduces energy use and carbon · 2. It creates an agile manufacturing line · 3. It provides greater ...
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[PDF] AN INTRODUCTION TO PETROLEUM REFINING AND THE ...Oct 24, 2011 · Petroleum refineries are large, capital-intensive, continuous-flow manufacturing facilities. They transform crude oils into finished ...
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[PDF] 5.1 Petroleum Refining1 - EPAThe petroleum refining industry converts crude oil into more than 2500 refined products, including liquefied petroleum gas, gasoline, kerosene, ...
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Blast Furnace ProcessA blast furnace is a steel cylinder lined with refractory. It operates continuously until the lining wears out, which takes many years to occur.
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Paper Machine - an overview | ScienceDirect TopicsA paper machine continuously forms, dewaters, presses, and dries a web of pulp fibers, using a dilute suspension applied to a wire screen.
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Real-Time Process Monitoring - an overview | ScienceDirect TopicsReal-time process monitoring refers to the continuous observation and assessment of a bioprocess using sensors that provide immediate information about the ...
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A framework for managing transitions in chemical plantsA desirable grade transition during polymer production ensures safety and stability of the process while minimizing off-spec production and reducing the time ...
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Understanding Unplanned Downtime Costs in the Chemical IndustryRating 4.5 (301) Feb 13, 2019 · In other situations, it can be sold as off-quality, but at less than premium product. The delta between what premium and off-spec product ...Missing: steel | Show results with:steel
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Continuous Production System Guide | Global Electronic ServicesSome of the benefits of continuous manufacturing include: Standardization: Continuous production is a carefully monitored, consistent process that uses ...
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A Semi-Continuous Operations Model For Solid-Dose ManufacturingNov 1, 2017 · In a semi-continuous process, the material is simultaneously charged and discharged from the process, but for a discrete time period (e.g., ...
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Parallel autonomous guided vehicle assembly line for a semi ...Purpose This paper aims to propose a parallel automated assembly line system to produce multiple products in a semi-continuous system.Missing: packaging | Show results with:packaging
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Continuous vs. Batch Process: What Are the Differences?Continuous processes are designed to produce products constantly without interruption.For example, manufacturing chemicals in a refinery is a continuous process ...Missing: blast furnaces
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[PDF] 2. The British Industrial Revolution, 1760-1860Arkwright's first 'water-frames' were driven by horses, and spun four threads at once. By. 1771 a water powered mill was established. In 1774, after the ...Missing: origins | Show results with:origins
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[PDF] Derwent Valley (United Kingdom) No 1030Jun 26, 2000 · However, it was not until Richard Arkwright constructed a water-powered spinning mill at Cromford in 1771, and a second, larger mill in 1776–77 ...
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History & Development - Derwent Valley MillsIt was Richard Arkwright's Cromford Mill which provided the true blueprint for factory production. ... The factory production of cotton yarn also led to cotton ...
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[PDF] National Historic Landmark Nomination - NPGalleryBy 1787 Evans had fully automated the flour-milling process, the first instance in history of a completely automated production facility." John J. McCusker ...
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Ahead of the Curve - September 7, 2016 - TAPPI.orgNov 1, 2017 · The Fourdrinier machine was the first to produce a continuous roll of paper by using a woven plastic or wire mesh conveyor belt, a principle ...
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The Steel Story - worldsteel.orgThen in 1709, Abraham Darby perfected the use of coke in a blast furnace to produce pig iron for pots and kettles. This new technique helped boost production, ...
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The Haber-Bosch Reaction: An Early Chemical Impact On ... - C&ENAug 18, 2008 · Ammonia production via the Haber-Bosch process ramped up in the 1910s just before and during World War I and quickly became a key player in ...Missing: continuous | Show results with:continuous
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Assembly Line Revolution | Articles - Ford Motor CompanySep 3, 2020 · Discover the 1913 breakthrough: Ford's assembly line reduces costs, increases wages and puts cars in reach of the masses.Missing: continuous | Show results with:continuous
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The refining and petrochemical industries: 170 years of innovationOct 5, 2020 · The 1940s saw an acceleration in petrochemical and refining technologies and the scaling of their operations, largely driven by these industries ...
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Taking a Look Back at Control: Part 2 - The Chemical EngineerOct 26, 2023 · The first process control computers were supervisory. That is, they adjusted setpoints on pneumatic or electric controllers. Thus, the plant ...
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Top tech: 75 years of automation milestonesComputer-based process control systems before the TDC 2000 were mainly data collection and alarm systems with control done by pneumatic loop controllers and ...<|separator|>
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[PDF] The Evolution of Commodity Markets Over the Past CenturyMay 11, 2022 · The first half of the 20th century featured electrification and mass production of steel, automobiles, telecommunications, chemicals, and ...
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[PDF] THE CONTINUOUS PROCESSOR FROM READCO KURIMOTO, LLCThe co-rotating shafts and close clearances between paddles and between the paddles and barrel walls provide efficient uniform mixing in less time than batch ...
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Readco offers continuous mixers for viscous materials | 2021-01-29Jan 29, 2021 · The proprietary design features twin, co-rotating screws within a closed barrel. The Continuous Processors can be custom engineered to ...Missing: paddle | Show results with:paddle
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Impacts of Rotor Design, Screw Design, and Processing Parameters ...Higher rotor speeds increased mixer melt temperature, whereas higher feed rates and smaller orifice openings produced lower mixer melt temperature. Overall ...
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(PDF) Effect of Continuous Mixer Design and Parameters on the ...Jun 4, 2025 · The feed rate was held constant at 20 kg/h and the extruder speed was fixed at 40 rpm. Although feed rate affects the fill level in the mixer ...
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In the Mix: Continuous Compounding Using Twin-Screw ExtrudersAn important type of plastics processing machinery known as a twin-screw extruder is used to mix fillers and additives with the polymer in a continuous ...
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Continuous processor | Food EngineeringApr 9, 2003 · Readco's Continuous Processor is a twin shaft, co-rotating mixer that can be used for everything from candy bars to cookie dough, cereal to chewing gum and ...
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Industrial Continuous Mixers | High-Performance Mixing Technologythe Continuous Processor can also be used for ...Missing: rotating paddle
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[PDF] Evaluation of Saltstone Mixer Paddle Configuration for Improved ...Sep 12, 2012 · Continuous co-rotating twin-screw mixers are beneficial for a variety of processes because scaling can be done from a small mixer to a larger ...<|control11|><|separator|>
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Flow Rate Calculation and Equations Q=VA - LMNO EngineeringFlow rate equation: Q = VA. If circular, then A = π D 2 / 4. The flow rate calculation does not check for unreasonable inputs such as negative values.Missing: throughput continuous rho
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[PDF] PID Theory Explained - Experimentation LabMar 29, 2011 · PID control is a common algorithm using proportional, integral, and derivative responses to compute output, based on sensor readings.
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Evolution of Modern DCS systems: A history and timelineIn the 1970s, the first DCS systems revolutionized industrial control by replacing analog control panels with digital interfaces, allowing operators to manage ...
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[PDF] History of Control History of PLC and DCSJun 15, 2012 · The largest part of the cost of analog control systems were the analog devices themselves, meaning that the cost of adding a control loop ...
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Distributed Control Systems – An Evolution - MMR ConsultingMay 24, 2020 · In DCS 1.0 designs, a module contains the scaling and digitizing electronics to convert 8 or 16 channels of analog readings into digitally ...
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(PDF) Control of an industrial process using PID control blocks in ...Many continuous industrial processes can be controlled using programmable automation controllers for digital implementation of classical PID control.
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Automation on the Job | American ScientistAutomatic control first took hold in continuous-process industries such as oil refining. A closed-loop control mechanism could regulate the temperature of a ...
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1910.119 App C - OSHAWhen the process is shut down in order to make a change, then the operating procedures must be updated before startup of the process. Training in how to handle ...
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[PDF] Safety Digest:Process unit startups and shutdowns are significantly more hazardous than normal oil refinery or chemical facility operations. A startup is a planned series ...Missing: continuous | Show results with:continuous
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[PDF] Current FDA Perspective for Continuous Manufacturing– Production time period; amount of material processed; production variation (e.g. ... • Process understanding is key to identifying product quality risks ...Missing: characteristics | Show results with:characteristics
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HSV valve locking systems | Increase plant safetyValve interlock systems provide a fail-safe system for the controlled opening and closing of valves. They are used whenever a specific opening and closing ...
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Emergency PLC Shut Down Systems: What You Need to KnowDec 7, 2022 · An emergency shutdown system (ESD) is an automatic safety mechanism designed to shut down a plant or facility when it enters a potentially ...
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Conducting HAZOPs in continuous chemical processes: Part I ...The aim of the present paper is to provide new tools and criteria for conducting HAZOPs in continuous chemical processes (eg, petroleum-refining processes).
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What is Predictive Maintenance? - IBMPredictive maintenance uses time series historical and failure data to predict the future potential health of equipment and so anticipate problems in advance.<|separator|>
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Predictive Maintenance in Manufacturing | CoreTigoOct 2, 2023 · Predictive maintenance in manufacturing is a transformative approach that leads to substantial cost savings, improved efficiency, and enhanced safety.
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10 Ways to Control Corrosion in Process Plants - SealxpertMay 2, 2017 · Corrosion is controlled by application of a biocide and a chemical treatment to control scaling and corrosion.
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Predictive Maintenance Solutions | Deloitte USPredictive maintenance aims to empower companies to maximize the useful life of their assets while avoiding unplanned downtime and minimizing planned downtime ...
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Detecting and Preventing Spills and Leaks - Chemical EngineeringMay 1, 2022 · This article covers prevention and detection measures for overfill and leak events, as well as instrumentation-specific requirements to accomplish these tasks.
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Safety Risks and Mitigation Strategies in Large-Scale Chemical ...Aug 24, 2025 · Impact: Leakage of toxic or flammable materials, leading to fires or explosions. Mitigation Strategies: Implement preventive maintenance ...
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Hazard and Operability Study (HAZOP) - SAFEChE: Process SafetyA HAZOP study is a structured analysis in process design to identify potential process safety incidents that a facility is vulnerable to.
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Continuous Manufacturing of Recombinant Drugs - PubMed Central... continuous manufacturing [146]. The economic analysis includes payback periods of 3–5 years for greenfield implementations and 4–7 years for retrofits, net ...
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Converting batch production to continuous processing - FeaturesMar 30, 2023 · COMPLEX chemicals are mostly produced in batch while energy and other costs could be halved by moving to continuous production. This unique ...Missing: multiple | Show results with:multiple
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Continuous drug manufacturing offers speed, lower costs | MIT NewsMar 12, 2012 · “Once you go to continuous, you begin to have continuous monitoring, so it's much easier to control the quality,” says Jensen, the Warren K.
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Batch Processing vs. Continuous Processing | Learning CenterJan 9, 2023 · Enhanced quality control: Continuous manufacturing allows for more consistent and accurate measurement of ingredients and finished products.Advantages Of Batch... · Batch Vs. Continuous... · Benefits Of Continuous...
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Ethylene Production and Its Role in Shaping the Modern Worldthe primary industrial process of producing ethylene and other valuable chemicals — involves breaking down larger hydrocarbon molecules (2, 3, ...
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Oil and Petroleum Products Explained: Refining Crude Oil - EIAFeb 22, 2023 · Petroleum refineries convert (refine) crude oil into petroleum products for use as fuels for transportation, heating, paving roads, and generating electricity.Missing: continuous utilization
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A-ConCrystal™continuous-process MCC technologyANDRITZ has developed continuous process technology for wood pulping for several decades, and now this technology has been adapted for MCC manufacturing. It ...
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Engineering improved ethylene production: Leveraging systems ...Ethylene is a small hydrocarbon gas widely used in the chemical industry. Annual worldwide production currently exceeds 150 million tons, producing ...
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[PDF] Manufacturing Ethylene: Facts, Impacts, and Pathways - ACEEEThe estimated global market flow of ethylene which shows the five main intermediate chemical products derived from ethylene. Data sources available upon ...
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[PDF] Ethylene Production - Emerson GlobalThe first step in the production of ethylene is to take the feedstock and crack it into ethylene and other various products in a furnace. This process is called ...
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The steel industry in 2050 - SMS group GmbHMar 6, 2024 · In 2022, 71% (1,347 million tons) of steel was produced using the traditional blast furnace and BOF (Basic Oxygen Furnace) route. This ...
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The Blast Furnace: 800 Years of Technology ImprovementFeb 23, 2023 · By 1950 the average blast furnace in the US was producing 265,000 tons of iron a year, at which point the US was producing more than half the ...<|separator|>
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Pulp digester overviewNov 25, 2023 · Continuous Digesters: Features: The continuous digester can achieve continuous production and is suitable for large-scale pulp production lines ...Continuous Digesters · Pulp Digesters · Role In Pulp Production Line
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AF&PA Details U.S. Paper Production and Capacity TrendsMay 16, 2025 · In 2024, U.S. paper production increased 3.2%, but capacity declined 2.0% to 78.1 million tons. The operating rate was 87.5%. Containerboard ...
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[PDF] UNECE/FAO Data Brief 2023 Pulp, paper and paperboardNov 21, 2023 · The total paper and paperboard production in North. America fell by 0.3% in 2022 to 76.5 million tonnes caused by market-related and unplanned ...
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Refined Petroleum Products Market Size, Growth Report, 2033Oct 13, 2025 · In 2023, over 4.5 billion metric tons of crude oil were processed globally, producing refined products such as gasoline, diesel, jet fuel, ...
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Refinery Utilization 101: The Other Half of the Capacity StoryJul 8, 2022 · Refinery utilization, measures how much crude oil refineries are processing or “running” as a percentage of their maximum capacity.Missing: continuous | Show results with:continuous
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[PDF] 5.1 Petroleum Refining - U.S. Environmental Protection AgencyA refinery's processing flow scheme is largely determined by the composition of the crude oil feedstock and the chosen slate of petroleum products. The example ...
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Potential Cost Savings as US Manufacturers Spend Billions on ...Jun 24, 2021 · Manufacturers have reported significant savings as a result of investing in improved maintenance, including 35% to 45% reductions in downtime and 65% to 95% ...
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Applied Materials Unveils Next-Gen Chipmaking Products toOct 7, 2025 · 07, 2025 (GLOBE NEWSWIRE) -- Applied Materials, Inc. today introduced new semiconductor manufacturing systems that boost the performance of ...
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A Pathway Towards Net-Zero Emissions in Oil Refineries - FrontiersFeb 10, 2022 · An increase in the CO2 capture rate of the CCS plant generally goes in hand with an increase in overall (absolute) energy consumption and thus ...<|control11|><|separator|>
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Continuous process design of the microwave chemical recycling of ...Sep 20, 2024 · Waste plastics can be used as feedstock to production new plastics by diverting them from landfills or oceans to appropriate industries.
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Development of novel filament production setup of continuous fiber ...Sep 26, 2025 · Additive Manufacturing particularly FDM has become prominent for producing complex, lightweight structures due to its design flexibility, ...
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Typical Cases of Continuous Flow Chemistry in Pharmaceutical ...Mar 2, 2025 · In this brief review, the synthetic processes of 14 drugs were intensified by continuous flow chemistry from 2023 to 2024.
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