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Phenomics

Phenomics is the systematic study of phenotypes—the observable physical, biochemical, and behavioral traits of organisms—on a genome-wide scale, integrating high-throughput technologies to comprehensively characterize and analyze these traits in relation to genetic, environmental, and developmental factors.^[1] This field emerged as a transdisciplinary approach following the completion of the Human Genome Project, addressing the need to bridge the gap between genomic data and phenotypic outcomes by developing standardized methods for large-scale phenotyping.^[2] The term "phenome" refers to the entire set of phenotypes expressed by an organism, analogous to the genome, and phenomics seeks to map this phenome to uncover complex genotype-phenotype interactions.^[2] The foundational proposal for phenomics came in 2003 with the "Human Phenome Project," advocated by Nelson Freimer and Chiara Sabatti, which called for an international initiative to build comprehensive phenotypic databases and analytical tools to support genome-wide association studies and personalized medicine.^[2] This vision highlighted the limitations of traditional, low-throughput phenotyping methods, which could not keep pace with rapid advances in genotyping technologies like single-nucleotide polymorphism arrays.^[1] Key principles of phenomics include the use of informatics for data integration, transdisciplinary collaboration across genetics, neuroscience, and engineering, and a focus on quantitative trait analysis to account for environmental influences and genetic complexity.^[1] In practice, phenomics employs advanced imaging techniques such as hyperspectral imaging, fluorescence microscopy, and tomography to enable non-destructive, high-throughput assessment of traits like plant growth, root architecture, or human cognitive functions.^[3] Applications span biomedical research, where it aids in studying neuropsychiatric disorders by linking genetic variants to behavioral phenotypes, and agriculture, where facilities like the Australian Plant Phenomics Network (APPN) support crop breeding for traits such as drought tolerance and yield efficiency amid climate challenges; as of 2025, the APPN has expanded with new nodes to enhance these efforts.^[1]^[3]^[4] Recent initiatives, such as the Human Phenotype Project, continue to advance deep phenotyping for personalized medicine.^[5] By facilitating precise genotype-environment interactions, phenomics drives innovations in precision agriculture, drug discovery, and evolutionary biology, underscoring its role in translating genomic knowledge into actionable insights.^[3]

Definition and Fundamentals

Core Concepts

Phenomics is defined as the acquisition of high-dimensional phenotypic data on an organism-wide scale, enabling the systematic study of phenotypes through high-throughput methods that capture physical, biochemical, and behavioral traits across populations or varying environments.^[6] This approach emphasizes scalability, moving beyond traditional low-throughput analyses of individual traits to comprehensive datasets that reveal complex interactions within biological systems.^[7] The phenotype refers to the observable characteristics of an organism, encompassing a broad continuum of traits that arise from the interplay between genotype and environment, often mediated by epigenetic processes.^[7] Unlike the discrete nature of genotypic data, phenotypes occupy a continuous "P space" of high dimensionality, where even subtle environmental changes can produce significant variation.^[7] Central to phenomics is the concept of the phenome, analogous to the genome, representing the complete set of an individual's phenotypes, which requires extensive measurement to fully map genotype-phenotype relationships.^[6] Key principles in phenomics include phenotypic plasticity, which describes the capacity of a single genotype to generate diverse phenotypes in response to environmental cues, highlighting the dynamic nature of trait expression.^[6] Trait heritability quantifies the proportion of phenotypic variation attributable to genetic differences among individuals, typically estimated through additive genetic variance, and is crucial for understanding evolutionary potential and breeding outcomes.^[7] These concepts underscore the need for phenomics to integrate genetic and environmental factors at scale, providing insights into how traits evolve and adapt. Phenotyping approaches in phenomics are distinguished by their focus on qualitative versus quantitative traits, with qualitative methods assessing categorical features such as color patterns or morphological categories, often through visual or descriptive scoring, while quantitative methods measure continuous variables like growth rates or biomass accumulation using precise instrumentation. This distinction allows for targeted analyses, where qualitative traits inform discrete classifications and quantitative traits enable statistical modeling of variation and correlations across the phenome.^[6]

Relation to Other Omics Disciplines

Phenomics distinguishes itself from other omics disciplines by focusing on the comprehensive measurement and analysis of phenotypes—the observable characteristics and traits of organisms—rather than upstream molecular components. Genomics examines the structure and function of genomes, including DNA sequences and variations, while transcriptomics studies gene expression through RNA profiles, proteomics investigates protein structures and interactions, and metabolomics analyzes small-molecule metabolites. In contrast, phenomics integrates these layers to capture the holistic, downstream outcomes of genetic, environmental, and interactive influences on organismal form, function, and behavior, enabling a bridge from molecular data to real-world traits.^[1]^[8] A core aspect of phenomics lies in its role within multi-omics integration, where it acts as the essential readout for mapping genotypes to phenotypes (G2P). This integration combines data from genomics, transcriptomics, proteomics, and metabolomics to elucidate how genetic variations translate into observable traits, often through approaches like quantitative trait loci (QTL) analysis, which identifies genomic regions associated with complex, quantitative phenotypes such as plant height or disease susceptibility. For instance, high-throughput phenotyping platforms in phenomics facilitate QTL mapping by providing dense phenotypic data that reveal dynamic genetic architectures underlying trait development, enhancing the precision of G2P predictions in crops and model organisms.^[9]^[10]^[11] In systems biology, phenomics provides critical functional validation for discoveries in other omics fields, particularly by revealing how environmental factors modify genetic effects on phenotypes. It supports the construction of holistic models that account for gene-environment interactions, such as how stressors alter trait expression in response to genomic variants, thereby uncovering mechanisms of phenotypic plasticity and robustness. This validation is vital for understanding complex biological networks, where phenomics data confirm or refine hypotheses from genomic studies, for example, in identifying modifier influences on disease traits or adaptive responses in populations.^[12]^[13]^[14] Despite these synergies, integrating phenomics with other omics faces significant challenges in data harmonization, stemming from heterogeneous data types, scales, and formats across layers. Phenotypic data, often high-dimensional and context-dependent, require standardized representations to align with molecular omics, leading to issues like incomplete annotations or incompatible scales that hinder cross-layer analyses. Unified ontologies, such as the Unified Phenotype Ontology (uPheno), address these by providing frameworks for consistent encoding of phenotypes across species and experiments, facilitating interoperability and reducing biases in multi-omics pipelines.^[15]^[16]^[17]

Historical Development

Origins in Genomics Era

The completion of the Human Genome Project in 2003 marked a transformative milestone in biology, concluding the initial phase of large-scale genome sequencing and redirecting research efforts toward deciphering how genetic variations manifest in observable traits and functions. This post-genomic shift emphasized the limitations of genomic data alone in explaining biological complexity, prompting the development of phenotype-centric approaches to integrate genotypic information with phenotypic outcomes. As a result, phenomics emerged in the early 2000s as a discipline aimed at systematically studying phenotypes on a scale comparable to genomics, addressing the need to interpret vast genetic datasets through comprehensive trait analysis.^[18] Key conceptual foundations for phenomics were laid by researchers advancing systems biology, notably Leroy Hood, who co-founded the Institute for Systems Biology in 2000 and championed an integrative framework that combined genomic, proteomic, and phenotypic data to model whole biological systems. Hood drew an explicit analogy between the Human Genome Project and a prospective "phenome project," arguing that just as genome sequencing revolutionized genetics, high-throughput phenotyping would be essential for predictive, personalized, and preventive medicine by capturing dynamic trait responses to genetic and environmental factors. This vision positioned phenomics as a critical extension of systems biology, highlighting the necessity of phenotype measurement to uncover emergent properties in complex organisms.^[19]^[20] Early practical applications of phenomic principles focused on model organisms whose genomes had been sequenced shortly before, such as Arabidopsis thaliana and Drosophila melanogaster in 2000, where researchers recognized that genotypic data insufficiently accounted for trait diversity without detailed phenotypic characterization. In these systems, initial efforts involved developing automated imaging and screening methods to quantify morphological and physiological variations across mutants, enabling the mapping of gene functions to specific traits and revealing the multifaceted influences of genetics on development. For instance, in Drosophila, high-dimensional phenotyping of wing shape and size variations demonstrated the polygenic basis of traits, underscoring the value of phenomics in evolutionary studies. Similarly, Arabidopsis served as a platform for screening environmental responses in root and leaf growth, bridging genomic annotations to phenotypic plasticity.^[21]^[22] A seminal publication advancing these ideas was the 2010 paper by Houle et al., which formalized "phenomics" in the context of quantitative genetics as the acquisition and analysis of high-dimensional phenotypic data across entire organisms, analogous to genomics but focused on bridging the genotype-phenotype gap. This work emphasized the challenges and promises of scaling phenotypic measurements to match genomic throughput, advocating for phenomics as an independent discipline to enhance understanding of variation, fitness, and disease. By prioritizing comprehensive trait screening over targeted assays, the paper established phenomics as a high-impact approach for post-genomic biology, influencing subsequent methodological developments in model systems.^[23]

Key Milestones and Advancements

In the 2010s, phenomics advanced significantly through the development of automated high-throughput imaging platforms, enabling scalable phenotypic data collection. Companies like LemnaTec pioneered systems such as the Scanalyzer3D, which integrated multispectral imaging, 3D reconstruction, and environmental controls to quantify plant growth traits non-destructively, with installations worldwide by the early 2010s supporting crop improvement research.^[24] Concurrently, the launch of large-scale facilities marked institutional commitment to phenomics; the UK National Phenome Centre, established in 2012 by the Medical Research Council and National Institute for Health Research, introduced advanced metabolic phenotyping capabilities, analyzing thousands of human samples annually to link genotypes to disease phenotypes.^[25] The integration of artificial intelligence and machine learning further transformed trait extraction from phenotypic data during this decade. In 2015, the release of open-source tools like PlantCV, a Python-based image analysis platform, facilitated automated processing of high-throughput images for traits such as leaf area and biomass, accelerating phenomics workflows in plant research.^[26] This paved the way for the rise of deep learning models, particularly convolutional neural networks, which by the late 2010s improved accuracy in segmenting complex structures like roots and fruits from images, reducing manual annotation needs and enhancing throughput in both plant and animal phenomics studies.^[27] Global collaborative efforts solidified phenomics as a unified field, with the International Plant Phenotyping Network (IPPN) founded in 2015 to coordinate standards and resource sharing among over 30 centers worldwide, fostering interoperability in plant phenotyping protocols.^[28] In human phenomics, expansions via biobanks advanced the field; the UK Biobank initiated its imaging study in 2014, collecting MRI, DXA, and ultrasound data from 100,000 participants to enable phenome-wide association studies linking imaging phenotypes to genetic and environmental factors.^[29] As of 2025, recent milestones include CRISPR-phenomics approaches that systematically link gene edits to observable phenotypes, exemplified by studies using CRISPR-Cas9 to modify gibberellin pathways in tomatoes, followed by deep learning-based volumetric phenotyping to quantify growth variations under controlled conditions.^[30] The COVID-19 pandemic accelerated digital phenotyping in health research, with smartphone and wearable-derived data capturing behavioral shifts like mobility reductions during lockdowns, demonstrating the feasibility of real-time phenomics for monitoring population-level health responses and informing post-pandemic surveillance strategies.^[31]

Technologies and Methods

Phenotyping Techniques and Instrumentation

High-throughput phenotyping techniques enable the systematic capture of phenotypic data across large populations, facilitating the measurement of traits such as growth, morphology, and physiology in a non-destructive manner. These methods rely on advanced instrumentation to generate quantitative data at scale, often integrating multiple sensors for comprehensive trait assessment.^[32] Imaging techniques form the cornerstone of modern phenotyping, with RGB imaging providing visible-spectrum data for basic morphological traits like leaf area and plant height. RGB cameras mounted on automated systems can estimate morphological traits through pixel-based segmentation. Hyperspectral imaging extends this capability by capturing data across hundreds of narrow spectral bands, allowing non-destructive evaluation of biochemical traits like water content and nutrient status. In barley studies, hyperspectral sensors have quantified chlorophyll distribution with high precision, correlating spectral reflectance to photosynthetic efficiency. 3D imaging, utilizing stereoscopic cameras or structured light projectors, reconstructs plant architecture to measure biomass and volume; stereoscopic setups, for example, have been applied to wheat for volumetric biomass estimation, reducing destructive sampling needs by over 90%.^[32]^[33]^[34] Sensor-based methods complement imaging by targeting specific physiological parameters, particularly through spectroscopy for biochemical phenotyping. Near-infrared spectroscopy detects traits like chlorophyll content via indices such as the Normalized Difference Vegetation Index (NDVI), defined as \text{NDVI} = \frac{\text{NIR} - \text{Red}}{\text{NIR} + \text{Red}}, where NIR and Red represent reflectance in near-infrared and red wavelengths, respectively; this index has been widely used in rice fields to monitor stress-induced chlorophyll decline. Environmental sensors, including soil moisture probes and temperature loggers, enable controlled simulations of abiotic stresses like drought in phenotyping setups.^[32]^[35] Phenotyping platforms vary by environment to balance control and realism. Greenhouse-based systems, such as conveyor-driven setups, transport plants past fixed imaging stations for repeated, non-invasive measurements under uniform conditions; the Scanalyzer platform, for example, processes up to 2,400 plants daily with integrated RGB and hyperspectral sensors for trait tracking in controlled experiments. In contrast, field-based platforms employ mobile technologies like drones equipped with LiDAR for large-scale monitoring; LiDAR-enabled UAVs have mapped crop height and biomass in sorghum fields, covering hectares in minutes while accounting for terrain variability.^[34]^[36] Effective experimental design is essential to mitigate phenotypic variability and ensure reliable data. Replication involves multiple instances of each genotype or treatment to estimate error variance, with studies recommending at least three to seven replicates for traits with moderate heritability to achieve statistical power. Randomization assigns treatments to experimental units without bias, preventing systematic errors from environmental gradients. Multi-environment trials further enhance robustness by testing phenotypes across diverse conditions, such as varying soils or climates, to capture genotype-by-environment interactions; for instance, trials across three sites have improved prediction accuracy for yield-related traits by 20-30%.^[37]^[38]

Data Standards and Computational Tools

Standardization efforts in phenomics rely on ontologies to ensure consistent annotation of traits and phenotypes across diverse studies and species. The Plant Ontology (PO) provides a controlled vocabulary for describing plant structures, growth stages, and morphological entities, facilitating the integration of phenotypic data with genomic and environmental information.^[39] Similarly, the Phenotype and Trait Ontology (PATO) defines qualities and attributes of phenotypes, such as size, shape, and color, enabling precise and interoperable descriptions that bridge entity-based annotations from the PO.^[40] Together, PO and PATO form the basis for standardized data representation in resources like the Planteome database, which supports cross-species comparisons by mapping traits to shared terminologies.^[41] These ontologies address the heterogeneity of phenomic datasets by promoting semantic interoperability, as demonstrated in workflows for curating phenotypes from model and crop plants.^[42] Computational pipelines in phenomics automate the processing of high-dimensional data, particularly from imaging modalities, to extract quantifiable traits. Tools such as fully-automated root image analysis (faRIA) employ convolutional neural networks (CNNs) for segmenting root structures in images, enabling precise measurement of length, volume, and branching angles with minimal human intervention.^[43] These pipelines typically involve preprocessing steps like noise reduction and segmentation, followed by feature extraction using machine learning models trained on annotated datasets to identify phenotypic variations.^[44] For instance, CNN-based approaches in root phenotyping achieve high segmentation accuracies, such as Dice coefficients of 0.87 on maize root images in complex soil backgrounds.^[43] Such software integrates with broader analysis frameworks to handle time-series data from automated imaging platforms. Handling the scale of phenomic big data requires specialized workflows and databases for storage, querying, and integration. The Galaxy platform supports reproducible phenomics pipelines through modular workflows that combine image processing, statistical analysis, and data visualization, allowing users to manage terabyte-scale datasets without extensive programming.^[45] PhenomeNET, a cross-species database, aggregates phenotype annotations using ontology mappings to compute similarity networks, aiding in gene prioritization and trait comparison across organisms like plants, mice, and humans.^[46] This resource employs semantic similarity metrics based on PATO-integrated ontologies to link disparate phenomic datasets, supporting queries for shared traits like growth defects or stress responses.^[47] Quality control in phenomics pipelines incorporates metrics to validate automated outputs against manual benchmarks and decompose phenotypic variance. Automated phenotyping tools reduce observer bias compared to manual measurements, though inter-tool variability can occur for complex geometries.^[44] Statistical models like analysis of variance (ANOVA) are applied to partition variance into genotype (G), environment (E), and GxE interaction components, with GxE representing a significant portion of total variation in field trials, guiding data filtering thresholds.^[48] These metrics ensure dataset reliability by flagging outliers and calibrating models, as seen in pipelines where reproducibility scores above 0.9 are targeted for longitudinal trait tracking.^[32]

Applications

Agriculture and Plant Breeding

Phenomics plays a pivotal role in agriculture by enabling precision breeding programs to select for complex traits that enhance crop resilience and productivity, particularly in the face of climate variability. High-throughput phenotyping platforms allow breeders to screen large populations for phenotypic variations under controlled or field conditions, accelerating the identification of superior genotypes without exhaustive manual assessments. This approach is especially valuable for traits like drought tolerance, where traditional methods are labor-intensive and time-consuming.^[49] In precision breeding, phenomics facilitates the high-throughput screening of root architectures to identify drought-tolerant varieties in crops such as wheat and maize. For instance, automated imaging systems using RGB, hyperspectral, and X-ray computed tomography have been employed to noninvasively phenotype hundreds of maize genotypes, revealing genetic loci associated with root traits that confer drought resistance, such as deeper rooting and reduced surface density. Similarly, in wheat, integrated high-throughput phenotyping with genome-wide association studies has identified image-based traits linked to drought tolerance, enabling the selection of varieties with improved yield stability under water-limited conditions. These techniques allow for the rapid evaluation of root system architecture, which is critical for water uptake efficiency in arid environments.^[50]^[51]^[52] Phenomics data further integrates with genomic selection models to refine genomic estimated breeding values (GEBVs) for key agronomic traits, such as yield under climate stress. By incorporating secondary phenotypic traits like canopy temperature and vegetation indices derived from high-throughput imaging, prediction accuracies for grain yield in wheat have improved by 56-70% in multi-trait models, allowing breeders to prioritize genotypes resilient to drought and heat. This synergy enhances the precision of GEBVs, reducing the reliance on costly field trials and enabling earlier selection in breeding pipelines.^[49]^[53] Notable case studies illustrate phenomics' practical impact in plant breeding. The Maize Genomes to Fields (G2F) initiative, launched in the 2010s, has evaluated over 180,000 field plots of maize hybrids across diverse North American environments, using high-throughput imaging and environmental sensors to predict field traits like grain yield and plant height through genotype-by-environment modeling. This effort has generated publicly available datasets that inform predictive phenomics for breeding climate-adaptive varieties. In rice, high-throughput phenotyping via drone-based hyperspectral imaging and automated platforms has supported screening for submergence tolerance, assessing traits such as underwater photosynthesis and post-flood regrowth to identify landraces with the SUB1A allele, which confers quiescence during flooding. These applications have accelerated the development of flood-resilient rice cultivars for flood-prone regions.^[54]^[55]^[56] Economically, phenomics contributes to substantial efficiencies in breeding programs by shortening development timelines and increasing genetic gains. Automated phenotyping platforms have reduced traditional breeding cycles, which often exceed 10 years, to under 5 years in some cereal crops by enabling rapid, non-destructive trait evaluation and higher selection intensities. This acceleration lowers costs associated with phenotyping—historically one of the largest expenses in breeding—and boosts overall crop productivity, supporting sustainable agriculture amid growing food demands.^[57]^[58]^[59] Recent advancements as of 2025 integrate phenomics with machine learning to transform plant breeding, enabling dynamic predictive modeling for sustainable crop improvement.^[60]

Biomedical and Human Health Research

In biomedical research, phenomics plays a pivotal role in characterizing complex human traits and diseases through high-throughput phenotyping in large-scale cohorts. The UK Biobank, encompassing over 500,000 participants, exemplifies this approach by integrating multimodal phenotyping data, including magnetic resonance imaging (MRI) for assessing body composition and cardiovascular structures, to identify risk factors for conditions like cardiovascular disease. For instance, precision MRI phenotyping has enabled the detection of subtle longitudinal changes in body composition among subsets of participants, linking these variations to metabolic and cardiovascular risks.^[61] Additionally, wearable sensors, such as accelerometers deployed in approximately 100,000 UK Biobank participants, capture physical activity patterns that correlate with reduced cardiovascular disease incidence, enhancing predictive models for health outcomes.^[62] In the context of rare diseases, phenomics leverages artificial intelligence (AI) for automated facial phenotyping to aid diagnosis, particularly for dysmorphic syndromes. The GestaltMatcher tool, a deep learning-based encoder, analyzes facial morphology from photographs to match patients with similar rare disorders, facilitating the recognition of ultra-rare conditions that affect fewer than 1 in 1,000,000 individuals. By integrating phenotypic descriptors with genetic data, GestaltMatcher has demonstrated high accuracy in clustering cases with shared variants, accelerating clinical diagnosis and enabling genotype-phenotype correlations in dysmorphology.^[63] This AI-driven approach outperforms traditional manual assessments, reducing diagnostic delays for syndromes like Cornelia de Lange or Noonan syndrome.^[64] Computational phenotyping from electronic health records (EHRs) further advances phenomics by extracting standardized phenotypes to uncover genotype-phenotype associations, particularly in pharmacogenomics. Algorithms applied to EHR data enable the identification of drug response traits, such as adverse reactions to medications like warfarin, by linking billing codes, laboratory results, and clinical notes to genetic variants.^[65] For example, phenome-wide association studies (PheWAS) using EHR-derived phenotypes have replicated and discovered novel associations between genes like HLA-B*57:01 and hypersensitivity to abacavir, informing personalized dosing strategies.^[66] This integration supports large-scale genomic analyses, with tools like EHR-Phenolyzer prioritizing candidate genes based on phenotypic profiles to enhance precision medicine applications. Advances in digital phenotyping utilize smartphone apps to passively collect real-time data on behavioral and physiological traits, offering insights into mental health conditions like depression. These apps track metrics such as mood variability, sleep duration, and physical activity via sensors, revealing patterns like reduced mobility and irregular circadian rhythms in depressive episodes.^[67] In studies of patients with major depressive disorder, multimodal digital phenotyping from smartphone interactions has predicted symptom severity with accuracies exceeding 80%, enabling early intervention through ecological momentary assessments.^[68] For bipolar disorder, app-based monitoring of activity and mood has identified distinct phenotypic clusters, distinguishing manic from depressive states and supporting longitudinal tracking in outpatient settings.^[69] As of 2025, digital phenotyping has expanded to provide comprehensive clinical benefits through real-time health monitoring via smart devices, further advancing precision medicine in mental health.^[70]

Ecology and Evolutionary Studies

Phenomics plays a pivotal role in ecology and evolutionary biology by enabling the high-throughput quantification of phenotypic variation in wild populations, which helps elucidate mechanisms of adaptation, speciation, and biodiversity maintenance. Through advanced field-based techniques, researchers can capture complex traits across individuals and populations, linking phenotypic data to environmental pressures and genetic underpinnings. This approach has transformed studies of natural systems, revealing how phenotypes respond to selective forces in real-time ecological contexts. In evolutionary studies, field phenomics has been instrumental in tracking adaptive traits, such as beak morphology in Darwin's finches (Geospiza spp.), where 3D imaging reveals how shape variations correlate with dietary shifts and environmental changes. High-resolution micro-computed tomography (µCT) scans of upper beaks from 15 finch species demonstrate that geometric parameters like curvature and sharpening rate define a morphospace tied to mechanical function, with seed-crushing species exhibiting higher curvature for enhanced leverage.^[71] These scans, combined with developmental models, show how growth zone dynamics generate shape diversity, facilitating rapid adaptation during events like droughts that alter food availability.^[71] Similarly, molecular analyses identify two independent developmental modules—the prenasal cartilage regulated by Bmp4 and CaM, and the premaxillary bone by TGFβIIr, β-catenin, and Dkk3—that decouple beak depth from width, promoting evolutionary flexibility in response to island-specific selective pressures. For biodiversity monitoring, phenomics leverages unmanned aerial vehicles (UAVs) to phenotype forest canopies at scale, identifying species and assessing ecosystem health without invasive sampling. In tropical and temperate forests, drone-mounted LiDAR and multispectral sensors quantify canopy structure, arthropod diversity, and parasitic infestations like mistletoe (Viscum album), enabling non-destructive surveys of understory and crown layers.^[72] Hyperspectral imaging from UAVs has mapped species richness in wetlands and mangroves, correlating canopy traits with overall diversity metrics. These tools support community-scale assessments, where photogrammetric point clouds reveal dead wood distribution and functional trait variations, informing conservation strategies for habitat recovery. Phenomics also informs phenotypic plasticity in response to climate change, particularly through high-throughput assays of thermal tolerance in insects, which capture variation in critical thermal limits across populations. Automated motion-tracking software on video recordings measures critical thermal maximum (CTmax) and knockdown time in species like Drosophila melanogaster and D. subobscura, validating acclimation effects while scaling to hundreds of individuals daily.^[73] Such assays reveal genotype-environment interactions, with adults of pests like the fall armyworm (Spodoptera frugiperda) showing lower cold tolerance than larvae, highlighting vulnerabilities to shifting temperatures.^[74] These methods extend to broader arthropods, including ants and isopods, to predict adaptation limits under warming scenarios. Large-scale ecological phenomes emerge from integrating phenomics with environmental DNA (eDNA) metabarcoding and remote sensing, as seen in initiatives like the Earth BioGenome Project (EBP), which sequences eukaryotic genomes while incorporating phenotypic and eDNA data to model biodiversity dynamics. EBP's framework links genomic variation to phenotypic traits, using eDNA from hotspots to monitor unseen diversity and inform climate impacts on speciation. Coupling eDNA surveys with satellite-derived variables like normalized difference vegetation index (NDVI) and elevation explains up to 35% of community turnover in California ecosystems, generating high-resolution maps of beta diversity across forests and shrublands.^[75] This synergy advances essential biodiversity variables, enabling predictive models of ecosystem responses to global change.^[75] As of 2025, phenomics is advancing morphological evolution studies by integrating high-throughput 3D imaging and computational tools to analyze phenotypic changes over time in natural populations.^[76]

Challenges and Future Directions

Current Limitations and Ethical Considerations

One major technical limitation in phenomics is the high cost of advanced instrumentation required for high-throughput phenotyping, with high-end automated platforms often exceeding €3 million (approximately $3.3 million USD), restricting adoption primarily to well-resourced facilities.^[77] These expenses encompass not only initial acquisition but also ongoing maintenance, estimated at 5-10% of the purchase price annually, further compounded by the need for specialized sensors and software integration.^[77] Additionally, the massive data volumes generated—often in the range of hundreds of megabytes to terabytes for larger experiments from imaging and sensor arrays—overwhelm conventional storage and processing infrastructure, necessitating advanced computational resources that escalate operational costs.^[78]^[79] Logistical challenges further impede phenomics progress, particularly the lack of standardization across laboratories, which contributes to irreproducibility in phenotypic measurements and analyses.^[80] Variations in protocols, software, and calibration methods hinder data comparability, as proprietary systems limit sensor interoperability and require site-specific adjustments that undermine validation at scale.^[81] Environmental variability also confounds results, with factors such as diurnal light fluctuations causing over 20% deviations in trait estimates like plant size, and controlled setups failing to replicate field conditions, such as limited root volumes in small pots that alter growth responses.^[77] These issues amplify noise in datasets, complicating accurate phenotyping across diverse experimental contexts.^[82] Ethical considerations in phenomics are pronounced, especially regarding privacy in human applications, where compliance with regulations like the EU's General Data Protection Regulation (GDPR) poses significant barriers for biobank-based research.^[83] GDPR treats pseudonymized health and genetic data as personal information, restricting secondary uses without specific consent, which is often infeasible for large-scale phenomic studies involving longitudinal or cross-border data sharing.^[83] Equity concerns arise from unequal access to phenomics technologies, as high costs favor well-funded institutions in developed regions, leaving national agricultural and biomedical research systems in developing countries underserved and exacerbating global disparities in research capacity.^[57] Furthermore, biases in AI-driven phenotyping stem from underrepresentation of diverse populations in training datasets, leading to models that perform poorly for underrepresented groups by race, ethnicity, or socioeconomic status, thereby perpetuating health inequities.^[84]

Emerging Trends and Technological Prospects

Recent advancements in artificial intelligence (AI) and automation are revolutionizing phenomics by enabling real-time phenotyping through edge computing on unmanned aerial vehicles (UAVs) or drones, allowing for instant analysis of plant traits in field conditions. Deep learning models, such as convolutional neural networks (CNNs) like enhanced Faster R-CNN and lightweight architectures like MobileNet, facilitate on-device processing of multispectral imagery to detect traits like yield and stress with high accuracy, achieving up to 99.53% in maize seedling identification.^[85] These systems address current limitations in data latency and computational demands by performing inference directly on drones, enhancing scalability for large-scale crop monitoring.^[85] Portable and low-cost sensors are democratizing phenomics access, particularly in developing regions where high-end equipment is prohibitive. Smartphone attachments, such as 3D-printed diffraction gratings costing around $130, convert standard cameras into visible-range hyperspectral imagers for trait assessment, while multispectral sensors like the Unispectral Monarch II ($1,000) enable deployment on mobile devices for vegetation indices.^[57] These innovations support national agricultural research systems in resource-limited areas by reducing costs from tens of thousands to under $3,000 per setup, fostering genetic gain in crops like cassava through shared regional hubs.^[57] The fusion of multi-omics data with phenomics using graph neural networks (GNNs) holds promise for predictive modeling of complex traits, integrating genomics, transcriptomics, and phenotypic data to uncover genotype-environment interactions. Methods like COGCN employ GCNs and cross-omics tensors to extract features via principal component analysis and model omics interactions, achieving Pearson correlation coefficients of 0.591 for maize yield prediction, outperforming baselines by 0.8–13.1%.^[86] Similarly, AI frameworks incorporating GNNs, such as GEARS, enable multi-scale predictions across species by leveraging knowledge graphs for phenotype forecasting.^[87] Prospects for synthetic phenomics include designing targeted phenotypes via optogenetics in model organisms, allowing precise spatiotemporal control of gene expression to engineer developmental traits. Optogenetic tools, like light-inducible systems, enable direct manipulation of cellular processes in organisms such as Drosophila and Arabidopsis, establishing cause-effect links between genetic activities and phenotypes for evolvability studies.^[88] In plants, predictive synthetic circuits reprogram traits like growth patterns with high fidelity, offering tools for rapid engineering.^[89] By 2030, initiatives like the International Human Phenome Project aim to compile global phenome atlases through platforms such as PhenoBank, creating comprehensive databases of human traits from macro to micro levels to support precision medicine and biodiversity research.^[90]^[91]

Research Coordination and Communities

Major Organizations and Networks

The International Plant Phenotyping Network (IPPN), established in 2015, serves as a global association of major plant phenotyping centers, currently linking nearly 30 facilities to promote research, standardize methodologies, and enhance the visibility of plant phenotyping efforts.^[28] Coordinated by leading institutions, the IPPN facilitates the exchange of information on phenotyping technologies and best practices through working groups and a web-based platform, addressing key challenges in data integration and interoperability across diverse research environments.^[92] As of 2025, the IPPN is planning the 9th International Plant Phenotyping Symposium (IPPS9) for 2026, potentially co-hosted in Africa to expand global participation.^[93] In the realm of human phenomics, the NIH-funded PhenX Toolkit, launched in 2007, functions as a central resource for standardized measurement protocols of phenotypes and exposures, enabling consistent data collection across biomedical studies.^[94] Developed by RTI International under the National Human Genome Research Institute, the toolkit catalogs high-priority protocols for complex traits, supporting reproducibility in genetic and epidemiological research by promoting consensus measures that align with broader data standards.^[95] The European Infrastructure for Multi-Scale Plant Phenotyping and Simulation for Food Security in a Changing Climate (EMPHASIS) represents a pan-European effort to integrate phenotyping capabilities, providing researchers access to advanced facilities for analyzing genotype performance under varying environmental conditions.^[96] As an ESFRI-listed project, EMPHASIS overcomes technological barriers in phenotyping by offering multi-scale resources and services, fostering collaboration among European institutions to advance sustainable agriculture.^[97] In the United States, the National Science Foundation (NSF) supports phenomics through joint initiatives and grants, such as collaborative programs with the USDA that fund high-throughput phenotyping technologies for crops and livestock.^[98] These efforts back specialized centers, including the NSF-funded Arkansas Center for Plant Powered Production, which develops phenomics tools to bridge genomic and phenotypic data for agricultural innovation.^[99] Funding bodies play a pivotal role in sustaining phenomics infrastructure worldwide. The European Union's Horizon Europe program allocates resources to projects like EMPHASIS-GO, which operationalizes pan-European phenotyping networks to enhance research integration and food security.^[100] Similarly, the USDA's Agricultural Genome to Phenome Initiative (AG2PI), administered by the National Institute of Food and Agriculture, provides competitive grants for multidisciplinary research linking genomes to phenomes in agriculturally significant species, supporting infrastructure development and collaborative science. As of July 2025, AG2PI continues to fund new projects focused on open data access and interdisciplinary approaches.^[101]

Collaborative Initiatives and Databases

The Image Data Resource (IDR) functions as a public repository for high-quality bio-image datasets, particularly from microscopy studies, allowing researchers to access, search, and reanalyze phenotypic data from published experiments.^[102] IDR promotes the reuse of image-based phenomes by linking datasets to genes and cellular phenotypes, enhancing interdisciplinary investigations in cellular and organismal phenomics.^[103] In the 2020s, collaborative initiatives like the International Plant Phenotyping Network (IPPN) have advanced cross-continental data harmonization in plant phenomics by connecting major phenotyping centers worldwide to standardize methodologies and share resources.^[104] IPPN fosters global cooperation through events, working groups, and knowledge exchange, aiming to accelerate research in high-throughput phenotyping technologies.^[28] Open-access repositories, such as the Plant Genomics and Phenomics Research Data Repository (PGP), further support these efforts by providing infrastructure for publishing and archiving plant research data in compliance with international standards. Crowdsourcing platforms like Zooniverse enable citizen science contributions to phenotyping tasks, where volunteers assist in analyzing images for traits such as bacterial resistance, improving the scale and accuracy of large datasets. For instance, the "Infection Inspection" project on Zooniverse uses image classification to phenotype antibiotic resistance in Escherichia coli, bridging gaps in expert-limited analyses.^[105] The implementation of FAIR principles—Findable, Accessible, Interoperable, and Reusable—guides these platforms and repositories, ensuring phenomic data can be effectively discovered, integrated, and reused across studies, as demonstrated in plant phenotypic management systems. Multi-institution projects, such as the 1000 Fungal Genomes initiative, incorporate phenomics to annotate traits like biomass degradation potential across diverse fungal strains, combining genomic sequencing with large-scale phenotypic assays.^[106] This effort, involving international collaborations, has phenotyped over 1,000 strains to link genetic variations to functional traits, advancing trait annotation in fungal ecology and biotechnology.^[107]

References

[1]
Phenomics: The systematic study of phenotypes on a genome-wide ...
Phenomics is an emerging transdiscipline dedicated to the systematic study of phenotypes on a genome-wide scale. New methods for high-throughput genotyping ...
[2]
The Human Phenome Project - Nature Genetics
### Summary of Key Concepts from "The Human Phenome Project" (Nature Genetics)
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Phenomics - an overview | ScienceDirect Topics
Phenomics is defined as the study of plant growth, performance, and composition, utilizing various phenotyping tools to evaluate and dissect valuable traits in ...Lidar: An Important Tool For... · 1 Introduction · 1.2 Literature Review Of...
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Phenomics: the next challenge | Nature Reviews Genetics
... articles; article. Phenomics: the next challenge. Download PDF. Review Article; Published: 18 November 2010. Phenomics: the next challenge. David Houle, ...Missing: text | Show results with:text
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Numbering the hairs on our heads: The shared challenge ... - PNAS
Phenomics, the comprehensive study of phenotypes, is therefore essential to understanding biology. For all of the advances in knowledge that a genomic ...Missing: core | Show results with:core
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Extending the landscape of omics technologies by pathomics - PMC
Aug 7, 2023 · 1). Another overarching term in omics is phenomics (Fig. 1), which describes the comprehensive analysis of phenotypes characterized by multiple ...
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Integration of multi-omics technologies for crop improvement - NIH
When integrating the multi-omics datasets, “phenotype to genotype” and “genotype to phenotype” as well as the genotype and environment interaction should be ...
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High-Throughput Phenotyping and QTL Mapping Reveals the ...
Combining high-throughput phenotyping and large-scale QTL mapping dissects the dynamic genetic architecture of maize development by using a RIL population.
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Converging phenomics and genomics to study natural variation in ...
Quantitative trait locus (QTL): In genetic mapping, a QTL represents a genomic region that is genetically linked to functional genomic variation and ...
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Transforming the study of organisms: Phenomic data models and ...
Nov 24, 2020 · Thus, phenomics is the study of the phenome and how it is determined, especially in relation to genes and environmental influences. Integrated ...Results · Semantic Phenotypes Encoded... · Fig 4. Darwin Core Star...
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Yeast Phenomics: An Experimental Approach for Modeling Gene ...
Feb 6, 2015 · It is increasingly recognized that the phenotypic effects of environmental or genetic perturbation depend upon the functional/allelic status of ...
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Systems models, phenomics and genomics: three pillars for ... - NIH
Phenomics can support collection of architectural, physiological, biochemical and molecular parameters in a high-throughput manner, which can be used to support ...
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The Phenotyping Dilemma—The Challenges of a Diversified ... - NIH
Jan 30, 2019 · While one aspect of this challenge is the non-uniform data structures and lack of comparable standards across platforms, the more critical part ...
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Ten quick tips for avoiding pitfalls in multi-omics data integration ...
Jul 6, 2023 · Standardization and harmonization of data and metadata are key steps in multi-omics data integration because they help to ensure that data ...
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The Unified Phenotype Ontology (uPheno): A framework for cross ...
Sep 22, 2024 · Phenotypic data are critical for understanding biological mechanisms and consequences of genomic variation, and are pivotal for clinical use ...Missing: challenges | Show results with:challenges
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Human Genome Project Fact Sheet
Jun 13, 2024 · The Human Genome Project was a large, well-organized, and highly collaborative international effort that generated the first sequence of the human genome.
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Systems Biology and P4 Medicine: Past, Present, and Future - PMC
Apr 30, 2013 · Leroy Hood, M.D., Ph.D. 1President, Institute for Systems Biology, Seattle, WA, USA. Find articles by Leroy Hood.Missing: phenome | Show results with:phenome
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The Phenomics Revolution - Scientific American
Dec 7, 2022 · The current state of scientific wellness is analogous to the Human Genome Project in the 1990s, says Hood. Although it had a big price tag, it ...
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2000: Drosophila and Arabidopsis genomes sequenced
Jul 29, 2013 · Arabidopsis thaliana is the first plant to have its genome sequenced. This plant from the mustard family has become the plant biologists' ...
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THE DIMENSIONALITY OF GENETIC VARIATION FOR WING ...
David Houle. David Houle. Department of Biological Science, Florida State ... 09 August 2004. Accepted: 03 February 2005. Published: 01 May 2005. PDF.
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Phenomics: the next challenge - PubMed - NIH
A key goal of biology is to understand phenotypic characteristics, such as health, disease and evolutionary fitness. Phenotypic variation is produced ...Missing: seminal paper definition
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Crop Phenomics and High-Throughput Phenotyping: Past Decades ...
Feb 3, 2020 · In 2010, Houle et al. (2010) defined phenomics as the acquisition of high-dimensional phenotypic data on an organism-wide scale. In the field of ...<|separator|>
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History - National Phenome Centre
Founded in 2012 to deliver access to a world-class capability in metabolic phenotyping, to benefit the whole UK translational medicine community.
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A Versatile Phenotyping System and Analytics Platform Reveals ...
Oct 5, 2015 · However, we chose to develop a new trait extraction software platform for daily high-throughput image analysis, Plant Computer Vision (PlantCV).
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Deep Learning in Image-Based Plant Phenotyping - PubMed
Here, we review the basics of deep learning, assessments of deep learning success, examples of applications of deep learning in plant phenomics, best practices, ...
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International Plant Phenotyping Network (IPPN)
IPPN is an association representing the major plant phenotyping centers. IPPN was founded by the IBG2 in 2015 and links currently nearly 30 phenotyping ...
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The UK Biobank imaging enhancement of 100000 participants
May 26, 2020 · In 2014, UK Biobank started the world's largest multi-modal imaging ... The UK Biobank resource with deep phenotyping and genomic data.Missing: phenomics | Show results with:phenomics
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Volumetric Deep Learning-Based Precision Phenotyping of Gene ...
In this study, we utilized the CRISPR-Cas9 system to develop a new tomato cultivar optimized for vertical farming by editing the Gibberellin 20-oxidase ( ...
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Digital phenotyping and the COVID-19 pandemic - PubMed
Nov 19, 2020 · The data provides a proof of principle that digital phenotyping tools can identify changes in human behavior incited by a common external environmental factor.Missing: phenomics | Show results with:phenomics
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A Comprehensive Review of High Throughput Phenotyping ... - NIH
In this article, we review state-of-the-art image-based HTP methods with discussion on different imaging platforms, imaging techniques, and spectral indices ...
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Imaging technologies for plant high-throughput phenotyping: a review
This paper considers imaging technologies developed in recent years for high-throughput phenotyping, reviews applications of these technologies.
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High-Throughput Plant Phenotyping Platform (HT3P) as a Novel ...
Jan 12, 2021 · This review aims to provide ideas, thoughts, and insights for the optimal selection, exploitation, and utilization of HT3Ps.
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Utilization of Spectral Indices for High-Throughput Phenotyping - MDPI
Among them, RGB and hyperspectral imaging tools are widely used to evaluate the quantitative and qualitative attributes of plants. In most cases, raw image data ...<|control11|><|separator|>
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A Review of High-Throughput Field Phenotyping Systems
Jun 17, 2022 · The main goal of this paper is to review the state-of-the-art of high-throughput field phenotyping systems with a focus on autonomous ground robotic systems.
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(PDF) Experimental Designs for Next Generation Phenotyping
This chapter will discuss several experimental designs that can potentially be used for phenotyping under variable conditions, describing their various ...
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Experimental Design for Plant Improvement | SpringerLink
Jun 3, 2022 · Robust experimental designs respect fundamental principles including replication, randomization and blocking, and avoid bias and pseudo-replication.
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The Planteome database: an integrated resource for reference ...
Nov 23, 2017 · Plant Ontology. The PO was developed in response to the need for a standardized terminology to describe plant anatomy and developmental stages ...
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Phenotype and Trait Ontology (PATO) - OBO Foundry
PATO is used by the Human Phenotype Ontology (HPO) for logical definitions of phenotypes that facilitate cross-species integration. Type: annotation; Examples ...
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Planteome 2024 Update: Reference Ontologies and ...
Dec 6, 2023 · Here, we report on updates to the Planteome reference ontologies, namely, the Plant Ontology (PO), Trait Ontology (TO), the Plant Experimental ...
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An ontology approach to comparative phenomics in plants
Feb 25, 2015 · We developed a workflow to curate and standardize existing phenotype datasets for six plant species, encompassing both model species and crop plants with ...
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Fully-automated root image analysis (faRIA) | Scientific Reports
Aug 6, 2021 · We present a GUI-based tool for fully automated quantitative analysis of root images using a pre-trained CNN model, which relies on an extension of the U-Net ...
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Review Phenotypic Image Analysis Software Tools for Exploring and ...
Jun 27, 2018 · For live-cell imaging, software solutions include the ADAPT plugin for ImageJ (Barry et al., 2015) and NeuriteTracker (Fusco et al., 2016).
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Phenotype Association Tools in Galaxy
Running the workflow. The workflow is in the center panel; for its input we select the same results from Part 1 that we used for the join with the PolyPhen-2 ...
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PhenomeNET: a whole-phenome approach to disease gene discovery
Jul 6, 2011 · Our method implements a whole-phenome approach toward disease gene discovery and can be applied to prioritize genes for rare and orphan diseases.
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Integrating phenotype ontologies with PhenomeNET
Dec 19, 2017 · PhenomeNET consists of an ontology integrating species-specific phenotype ontologies based on the PATO ontology [4] and relations between ...
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Integrating High-Throughput Phenotyping and Statistical Genomic ...
In this review, we outline the current analytical approaches in quantitative genetics that are applied to longitudinal traits in crops throughout development.
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Prospectus of Genomic Selection and Phenomics in Cereal ...
Plant breeders and scientists are under pressure to develop new varieties and crops having higher yield, higher nutritional value, climate resilience, and ...
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Using high-throughput multiple optical phenotyping to decipher the ...
Jun 24, 2021 · Here we develop a high-throughput multiple optical phenotyping system to noninvasively phenotype 368 maize genotypes with or without drought stress over a ...
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Integrating high‐throughput phenotyping and genome‐wide ...
Jul 11, 2024 · Integrating high-throughput phenotyping and genome-wide association studies for enhanced drought resistance and yield prediction in wheat
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Root Phenotyping for Drought Tolerance: A Review - MDPI
Wheat genotypes with deeper roots, higher root density at depth, and less root density at the surface have higher yield under rain-fed conditions [76].
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Phenomic and genomic prediction of yield on multiple locations in ...
May 9, 2023 · Genomic selection, which allows prediction of performance based on large genome-wide marker datasets, has been applied in wheat breeding for ...Missing: GEBVs climate
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The Genomes To Fields Initiative - Home
A publicly initiated and led research initiative to catalyze and coordinate research linking genomics and predictive phenomics to achieve advances.Resources · Publications · About · Project Overview & Scope
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Leveraging data from the Genomes-to-Fields Initiative to investigate ...
Oct 30, 2023 · The Genomes-to-Fields (G2F) Initiative has tested maize hybrids in more than 130 year-locations in North America since 2014. Here, we curate and ...Missing: phenomics | Show results with:phenomics
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Discerning Genes to Deliver Varieties: Enhancing Vegetative
High-throughput phenotyping can be used ... The submergence tolerance regulator SUB1A mediates crosstalk between submergence and drought tolerance in rice.Qtls For Flooding Tolerance · Breeding Strategies · Proposed Strategy
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Affordable phenomics: Expanding access to enhancing genetic gain ...
Aug 6, 2025 · Affordable phenomics approaches are emerging to address the needs of plant breeders and researchers. Internet of things, 3D printing, ...ENGINEERING CUSTOM... · OPEN-SOURCE SOFTWARE... · CASE STUDIES IN...
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Phenomic Selection for Hybrid Rapeseed Breeding | Plant Phenomics
Jul 24, 2024 · We found that phenomic selection within the hybrid generation outperformed genomic selection for seed yield and plant height.Missing: paper | Show results with:paper
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Crop Phenomics: Current Status and Perspectives - Frontiers
Jun 2, 2019 · We provide an overview of crop phenomics research, focusing on two parts, from phenotypic data collection through various sensors to phenomics analysis.
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Precision MRI phenotyping enables detection of small changes in ...
Here we investigate changes in body composition in 3088 free-living participants, part of the UK Biobank in-depth imaging study.Missing: phenomics wearable sensors
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Association of wearable device-measured vigorous intermittent ...
Dec 8, 2022 · Here, we examined the association of VILPA with all-cause, cardiovascular disease (CVD) and cancer mortality in 25,241 nonexercisers (mean age ...
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GestaltMatcher facilitates rare disease matching using facial ...
To improve recognition of ultra-rare disorders, we developed GestaltMatcher, an encoder for portraits that is based on a deep convolutional neural network.Missing: dysmorphology | Show results with:dysmorphology
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Overcoming the limits of rare disease matching using facial ... - NIH
Therefore, in concert with mutation data, GestaltMatcher could accelerate the clinical diagnosis of patients with ultra-rare disorders and facial dysmorphism, ...
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Using Electronic Health Records to Generate Phenotypes for ...
Jan 1, 2020 · We describe here common and emerging electronic phenotyping approaches applied to electronic health records as well as current limitations of both the ...
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Extracting research-quality phenotypes from electronic health ...
Apr 30, 2015 · Robust replication of genotype-phenotype associations across multiple diseases in an electronic medical record. Am J Hum Genet. 2010;86:560 ...
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Digital Phenotyping for Monitoring Mental Disorders - NIH
Digital phenotyping is a new approach that uses measures extracted from spontaneous interactions with smartphones (eg, screen touches or movements) or other ...
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Multimodal Digital Phenotyping Study in Patients With Major ...
Feb 21, 2025 · This multimodal digital phenotyping study focused on different types of patients who were receiving treatment for major depressive episodes, ...
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Classifying and clustering mood disorder patients using smartphone ...
Dec 21, 2023 · Results support the potential for digital phenotyping methods to cluster depression, bipolar disorder, and healthy controls.
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https://pmc.ncbi.nlm.nih.gov/articles/PMC10753422/
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https://mental.jmir.org/2025/1/e63622/
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https://www.nature.com/articles/s41746-023-00977-7
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High-Throughput Assays of Critical Thermal Limits in Insects
Jun 4, 2025 · ... thermal adaptation, acclimation capacity and climate change ... environment interactions shape nutritionally mediated changes in cold tolerance.<|separator|>
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https://doi.org/10.1073/pnas.2105957118
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Pitfalls and potential of high-throughput plant phenotyping platforms
Aug 22, 2023 · Compared to traditional experiments, the use of high-throughput phenotyping systems often introduces additional constraints, that can impact the ...
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Unlocking the potential of plant phenotyping data through ...
Imaging methodologies used in plant phenotyping generate huge amounts of complex data. · The major challenge is data management: metadata collection and data ...
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Current challenges and future of agricultural genomes to phenomes ...
Jan 3, 2024 · Failing to advance methodologies could lead to inefficient land uses, shortages of agricultural products resulting in food insecurities, and ...
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Why does human phenomics matter today? - PMC - NIH
Sep 28, 2020 · Human phenomics responds to an urgent need in the medical research community, and that is the one of reproducibility, ensuring that published ...
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Opportunities and limits of controlled-environment plant phenotyping ...
This review outlines the opportunities and challenges of phenotyping approaches under controlled environments complementary to conventional field trials.
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Disruptive and avoidable: GDPR challenges to secondary research ...
Mar 2, 2020 · In this article, we describe challenges that GDPR has posed for biobanks and databanks and for researchers who use those banked resources for secondary ...Missing: phenomics | Show results with:phenomics
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Considerations for addressing bias in artificial intelligence for health ...
Sep 12, 2023 · Bias in any part of the healthcare process can lead to differential impacts on different groups, and historically has resulted in poorer health ...
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Application of Deep Learning Technology in Monitoring Plant ... - MDPI
In digital plant phenomics, deep learning has become a key technology for addressing the high dimensionality, complexity, and heterogeneity of phenotypic data.
[80]
COGCN: A multi-omics phenotype prediction method for maize ...
Aug 25, 2025 · The method combines omics-specific learning and cross-omics interactive learning to achieve better maize phenotype prediction performance. First ...
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AI-driven multi-omics integration for multi-scale predictive modeling ...
This framework will integrate multi-omics data across biological levels, organism hierarchies, and species to predict genotype-environment-phenotype ...
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Principles and applications of optogenetics in developmental biology
Oct 22, 2019 · Optogenetics allows us to establish very direct cause-effect relationships between gene activities and developmental phenotypes and to decode ...
[83]
Predictive genetic circuit design for phenotype reprogramming in ...
Jan 16, 2025 · Our study achieves predictable design and application of synthetic circuits in plants, offering valuable tools for the rapid engineering of plant traits.
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Human Phenomics: The next generation atlas to address global ...
The International Human Phenome Project aims to measure the human body in a precise and systematical manner, from macro to micro levels, from the start to the ...Missing: 2030 | Show results with:2030
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Report on the 4th Board Meeting of the International Human ... - PMC
May 26, 2024 · PhenoBank aims to create a global public platform for a comprehensive human phenome database and processing system following international ...Missing: 2030 | Show results with:2030
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About_IPPN - International Plant Phenotyping Network
The purpose of the IPPN is to promote science and research in the field of plant phenotyping, focusing particularly on these goals.
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The PhenX Toolkit: Recommended Measurement Protocols for ...
Mar 5, 2024 · Since 2007, PhenX has been funded by the National Human Genome Research Institute with co-funding from other National Institutes of Health (NIH) ...The Phenx Toolkit · Strategic Planning · Sdoh Working Group ProcessMissing: trait | Show results with:trait
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About - PhenX Toolkit
The PhenX Toolkit (consensus measures for Phenotypes and eXposures) provides recommended standard data collection protocols for conducting biomedical research.Missing: trait | Show results with:trait
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European Infrastructure for Multi-Scale Plant Phenotyping And ...
EMPHASIS (European Infrastructure for Multi-Scale Plant Phenotyping And Simulation for Food Security in a Changing Climate) is an infrastructure initiative ...
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EMPHASIS - ESFRI Roadmap 2021
EMPHASIS addresses the technological and organizational limits of European phenotyping, for a full exploitation of genetic and genomic resources available for ...
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NSF-USDA Joint Funding Opportunity - Early Concept Grants for ...
Mar 10, 2016 · A joint funding opportunity to support the development of transformative plant and animal phenomics, and microbiome technologies.
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Phenomics at the Arkansas Center for Plant Powered Production
Mar 7, 2022 · Recognizing this need the Arkansas Center for Plant Powered Production (P3; www.plantpoweredproduction.com) funded by the US National Science ...
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Bringing EMPHASIS to operation: European Infrastructure for multi ...
Mar 10, 2023 · The EU-funded EMPHASIS-GO project will bring the pan-European research infrastructure into operation, based on the achievements of the preparatory project ...Missing: Genotyping | Show results with:Genotyping
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Agricultural Genome to Phenome Initiative - USDA NIFA
Jul 23, 2025 · The National Institute of Food and Agriculture's Agricultural Genome to Phenome Initiative (AG2PI) focuses on collaborative science engagement.Missing: equity | Show results with:equity
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PhenomicDB: a multi-species genotype/phenotype database for ...
PhenomicDB is thought as a first step towards comparative phenomics and will improve our understanding of gene function by combining the knowledge about ...Missing: PhenomeNET | Show results with:PhenomeNET
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PhenomicDB: a multi-species genotype/phenotype database for ...
PhenomicDB is a multi-species genotype/phenotype database that allows scientists to compare and browse phenotypes for genes from different organisms.Missing: PhenomicsDB | Show results with:PhenomicsDB
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a bioimage data integration and publication platform | Nature Methods
Jun 19, 2017 · IDR provides an online resource and a software infrastructure that promotes and extends publication and reanalysis of scientific image data.
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Image Data Resource: IDR
IDR is a public repository of image datasets from published scientific studies, where the community can submit, search and access high-quality bio-image data.Cell - IDR · Data download · About · Resources
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International Plant Phenotyping Network
IPPN aims to provide all relevant information about plant phenotyping. The goal is to increase the visibility and impact of plant phenotyping.Affordable Phenotyping · Root Phenotyping · Applications of AI in Plant... · CareerMissing: 2015 | Show results with:2015
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Infection Inspection: using the power of citizen science for image ...
Aug 22, 2024 · This study uses citizen science and image feature analysis to profile the cellular features associated with antibiotic resistance in Escherichia coli.
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Large-scale phenotyping of 1,000 fungal strains for the degradation ...
Jul 15, 2021 · The global analysis presented herein above highlighted that most of the best-performing strains display a main phenotype, although minor “ ...
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MycoCosm portal: gearing up for 1000 fungal genomes - PMC
The MycoCosm portal enables in-depth multidimensional analysis of individual genomes and efficient comparative genomics of fungi, which may be applied to ...