Fact-checked by Grok 2 weeks ago

Positron emission

Positron emission, also known as β⁺ decay or beta-plus decay, is a type of in which a proton in the of an unstable, proton-rich is converted into a , accompanied by the emission of a (the antimatter counterpart of an ) and an . This process reduces the of the daughter by one while maintaining the , effectively transforming one into another with a lower . The occurs in isotopes with an excess of protons relative to neutrons, which are unstable due to the imbalance in nuclear forces, leading to a spontaneous reconfiguration for greater stability. The emitted , having the same mass as an but opposite charge, travels a short distance (typically millimeters to centimeters in biological tissue) before interacting with an orbital , resulting in that converts their combined mass into energy in the form of two oppositely directed photons, each with precisely 511 keV of energy. This annihilation signature is key to detecting and tracing the . Positron emission plays a critical role in , particularly in positron emission tomography (PET) imaging, where short-lived positron-emitting isotopes such as are incorporated into radiotracers to map metabolic and biochemical functions in the body, enabling early detection of conditions like cancer, neurological disorders, and cardiovascular diseases. These applications leverage the precise localization of annihilation gamma rays to reconstruct three-dimensional images of physiological processes with high sensitivity.

Fundamentals

Definition and Basics

Positron emission, also known as β⁺ decay, is a type of radioactive decay in which a proton within an unstable atomic nucleus transforms into a neutron, emitting a positron (e⁺) and an electron neutrino (ν_e) in the process. This decay mode occurs in neutron-deficient nuclei and serves to adjust the proton-to-neutron ratio toward stability, distinguishing it from other forms of radioactivity such as alpha decay (helium nucleus emission), beta-minus decay (electron and antineutrino emission), and gamma decay (photon emission). The is the counterpart of the , having an identical rest of 9.109 × 10⁻³¹ but carrying a positive of +1 (where ≈ 1.602 × 10⁻¹⁹ ). This transformation is governed by the weak , one of the four interactions, which facilitates the change in particle from to within the proton. The decay results in a daughter nucleus with the same A (total nucleons) but an Z reduced by 1, effectively transmuting the parent into the previous in the periodic table. The process can be represented by the nuclear equation: ^{A}_{Z}\mathrm{X} \to ^{A}_{Z-1}\mathrm{Y} + \mathrm{e}^{+} + \nu_e where X is the parent nucleus and Y is the daughter nucleus. In contrast to , another proton-to-neutron conversion process that absorbs an inner-shell without positron emission, positron emission requires sufficient energy to create the positron-neutrino pair.

Occurrence and Prevalence

Positron emission primarily occurs in proton-rich atomic nuclei located beyond the line of stability on the nuclide chart, where the proton-to- ratio exceeds that of stable isotopes, prompting the transformation of a proton into a to achieve greater stability. These unstable isotopes are typically found in lighter elements with atomic numbers Z < 60, though the process can extend to heavier nuclei under specific conditions. In natural settings, such emitters arise from interactions involving cosmic rays, which produce short-lived proton-rich species in the upper atmosphere, or from transient unstable nuclides generated during primordial nucleosynthesis processes in the early universe via weak interactions. In astrophysical environments, positron emission plays a notable role during stellar nucleosynthesis, particularly in explosive events like core-collapse supernovae and classical novae, where proton-rich nuclei are synthesized in high-temperature conditions and subsequently decay, releasing positrons that contribute to observed gamma-ray emissions. For instance, the decay of isotopes such as ^{56}Co and ^{44}Ti in supernova ejecta generates positrons that annihilate with electrons, producing characteristic 511 keV gamma rays detectable from Earth. Cosmic ray interactions further amplify this by creating positron-emitting isotopes throughout the galaxy, influencing the observed excess of positrons in cosmic ray spectra. Compared to beta minus decay, which dominates in neutron-rich nuclei and accounts for the majority of radioactive decays, positron emission is less prevalent overall due to the energetic disadvantages of producing and expelling a positively charged particle from the nucleus. It represents a minority pathway among unstable nuclides, occurring in proton-deficient cases alongside . On Earth, natural positron emitters are exceedingly rare in the crust, with providing a rare natural example through a minuscule branching ratio of about 0.001% of its decays. making laboratory production via accelerators or reactors the primary means of observation. Over 150 positron-emitting isotopes have been identified, spanning elements from to heavier metals, with many produced artificially for applications like medical imaging. This reflects ongoing discoveries in nuclear physics, though the prevalence remains limited relative to the thousands of beta minus emitters, underscoring positron emission's niche role in radioactivity.

Historical Development

Discovery

The theoretical foundation for positron emission was laid in 1928 by British physicist Paul Dirac, who developed a relativistic quantum mechanical equation to describe the behavior of electrons. Known as the , it combines quantum mechanics with special relativity and yields solutions for both positive and negative energy states, including particles with the mass of an electron but positive charge—later identified as positrons (antielectrons). The equation is given by (i \hbar \gamma^\mu \partial_\mu - m c) \psi = 0, where \psi is the wave function, \gamma^\mu are the Dirac matrices, m is the electron mass, c is the speed of light, and \hbar is the reduced Planck's constant. The experimental discovery of the positron occurred in 1932, when American physicist Carl David Anderson, working at the California Institute of Technology, observed tracks in a cloud chamber exposed to cosmic rays. These tracks, produced by particles passing through a lead plate, curved in the opposite direction to those of electrons under the influence of a magnetic field, indicating a positive charge with electron-like mass. Anderson's analysis confirmed the particles as positrons, providing the first evidence of antimatter and validating Dirac's prediction. In 1934, French physicists Irène Curie and Frédéric Joliot extended this work by demonstrating artificial positron emission. By bombarding with alpha particles from , they produced the unstable isotope , which decayed by emitting positrons to form . This marked the first controlled production of a positron-emitting radionuclide, opening the path to induced . Their discovery of artificial , including positron emission, earned them the 1935 Nobel Prize in Chemistry. Early supporting evidence included the characteristic 511 keV annihilation radiation observed when positrons combined with electrons, corresponding to twice the electron rest mass energy. Anderson's groundbreaking observation earned him the 1936 Nobel Prize in Physics, shared with Victor Hess for related cosmic ray research, recognizing the positron as a fundamental particle in the emerging quantum field theory.

Key Experiments and Milestones

In the late 1940s and 1950s, key experiments focused on verifying foundational aspects of the weak interaction underlying positron emission. Wolfgang Pauli proposed the neutrino hypothesis in 1930 to explain the continuous energy spectrum in beta decay, including positron-emitting processes, postulating an uncharged particle to conserve energy and momentum. This idea gained experimental support through the 1956 Cowan-Reines experiment, which detected antineutrinos from beta-minus decay but confirmed the neutrino's role in the inverse beta-plus process, thereby validating the particle's involvement in positron emission. Complementing this, Chien-Shiung Wu's 1956-1957 experiment on cobalt-60 beta decay demonstrated parity violation in the weak interaction by observing asymmetric electron emission from polarized nuclei at near-absolute zero temperatures, a result directly applicable to positron emission due to the shared weak force mediation. These findings established non-conservation of parity in weak decays, reshaping theoretical models for positron-emitting processes. During the 1960s and 1970s, precision measurements advanced understanding through detailed spectral analysis. Experiments using magnetic spectrometers, such as those on yttrium-90 and yttrium-91 beta decays, provided high-resolution shape measurements of beta spectra, revealing deviations from simple Fermi theory and supporting refinements in weak interaction couplings. These studies confirmed the vector-axial vector (V-A) structure of the weak interaction, originally proposed by Feynman and Gell-Mann, through correlations in positron emission angles and energies that matched V-A predictions over scalar or tensor alternatives. Cyclotrons and early linear accelerators played a crucial role in producing short-lived positron emitters like fluorine-18, enabling systematic spectral investigations that quantified branching ratios and endpoint energies with percent-level accuracy. In the 2000s, accelerator-based experiments expanded verification to high energies. The Large Electron-Positron (LEP) Collider at CERN, operational until 2000, collided positrons with electrons at up to 209 GeV, producing Z and W bosons to probe electroweak unification, with results confirming weak interaction parameters relevant to low-energy positron emission. Linear accelerators further supported precision studies by generating controlled positron beams for decay rate measurements in exotic nuclei. Recent advancements in the 2020s have leveraged computational simulations for decay predictions. Lattice quantum chromodynamics (QCD) calculations have computed hadronic matrix elements for beta decay processes, improving accuracy in positron emission rates for multi-nucleon systems and aiding beyond-Standard-Model searches. Ab initio nuclear theory, informed by QCD, has yielded precise beta decay calculations, such as for proton-to-neutron transitions emitting positrons, with uncertainties reduced to below 1%. Neutrino oscillation experiments like NOvA and T2K provided 2025 updates on mixing parameters, indirectly validating weak interaction models by testing CP violation asymmetries that influence early-universe positron emission scenarios. Ongoing cyclotron facilities continue systematic studies, producing isotopes for endpoint spectrum analyses that benchmark these simulations.

Physical Mechanism

Decay Process

Positron emission, or β⁺ decay, is a radioactive decay process in which a proton in the atomic nucleus transforms into a neutron, emitting a positron (e⁺) and an electron neutrino (ν_e). This occurs in proton-rich nuclei seeking greater stability by increasing their neutron-to-proton ratio. The fundamental nuclear reaction can be represented as
p \to n + e^+ + \nu_e,
where the Q-value of the decay, determined by the mass difference between parent and daughter atoms adjusted for the creation of the positron-electron pair, sets the maximum total kinetic energy available to the emitted particles.
At the quark level, the process is initiated by the charged-current weak interaction, in which an up quark (u) within a proton converts to a down quark (d) by emitting a virtual W⁺ boson: u \to d + W^+. The W⁺ boson then decays into the positron and electron neutrino: W^+ \to e^+ + \nu_e. This quark transformation effectively changes the proton (uud) to a neutron (udd). Only certain nuclear transitions are allowed under the weak interaction's selection rules for low-energy (allowed) β⁺ decays. These require a change in total angular momentum ΔJ = 0 or 1 (no parity change) and a change in isospin ΔI = 0 or ±1, with the prohibition of 0⁺ → 0⁺ transitions. Fermi transitions (ΔI = 0, no spin flip) arise from the vector part of the weak current, while Gamow-Teller transitions (ΔI = ±1, spin flip up to 1) arise from the axial-vector part. The emitted positrons exhibit a continuous kinetic energy spectrum from approximately 0 up to the Q-value (neglecting nuclear recoil), because the available energy is shared unpredictably among the three outgoing particles—the positron, neutrino, and daughter nucleus—in this three-body decay kinematics. After emission, the daughter nucleus is often left in an excited state due to the sudden change in nuclear structure, prompting de-excitation via to reach the ground state. The resulting daughter atom also experiences atomic rearrangement, forming a singly negatively charged ion, as the nuclear charge decreases by unity while the surrounding electron cloud initially retains its original Z electrons.

Particle Interactions

Following emission from the nucleus, the positron propagates through surrounding matter, primarily losing kinetic energy through ionization and atomic excitation processes. These energy losses occur via Coulomb interactions with atomic electrons, described by for positrons, which differs from for electrons due to the opposite charge of the positron. This positive charge leads to repulsive interactions with atomic nuclei and attractive ones with electrons, resulting in slightly lower stopping power compared to electrons of the same energy, with the minimum stopping power for positrons in silicon reaching approximately 1.46 MeV cm²/g at a Lorentz factor \gamma \approx 3.7. The positron's range in matter is thus typically on the order of millimeters for MeV-scale emission energies, allowing it to thermalize to non-relativistic speeds before further interactions. As the positron slows to thermal energies (around 10 eV or less), it undergoes annihilation with an atomic electron, a process governed by quantum electrodynamics. In the center-of-mass frame at rest, the annihilation produces two back-to-back gamma rays, each with an energy of 511 keV, corresponding to the rest mass energy of the electron-positron pair (m_e c^2 = 511 keV). The reaction is: e^+ + e^- \rightarrow 2\gamma where each \gamma photon carries 511 keV. If the positron and electron have relative motion at annihilation, momentum conservation requires a three-photon decay (e^+ + e^- \rightarrow 3\gamma), with a total energy of 1.022 MeV distributed among photons of lower individual energies (typically 0.2–0.8 MeV), occurring with a probability of about 1.99% relative to the two-photon channel. The direct annihilation cross-section in matter is small, on the order of $10^{-25} cm² per electron at thermal energies, leading to an average positron lifetime of approximately $10^{-10} s in typical condensed media. Environmental factors in the medium significantly influence the annihilation dynamics. At low energies, the positron can capture an electron to form , a short-lived exotic atom bound state analogous to the hydrogen atom but with reduced binding energy (6.8 eV for the ground state). Positronium formation competes with direct free annihilation and is more probable in dilute gases or low-density solids (up to 50–80% yield in some insulators), where the positron has a higher chance to avoid rapid capture by the medium's electron cloud; in denser metals, formation yields are suppressed below 10% due to enhanced electron density and screening effects. (singlet spin state) decays primarily to two 511 keV photons with a lifetime of 0.125 ns, while (triplet state) favors three-photon decay with a longer lifetime of 142 ns, though quenching by nearby electrons can shorten this in matter. These processes modulate the overall annihilation rate and photon spectrum. The characteristic 511 keV gamma-ray line serves as the primary detection signature of positron emission in spectroscopic analyses, arising from both direct two-photon annihilation and para-positronium decay. This narrow line, often observed with a full width at half maximum of a few keV due to Doppler broadening from residual motion, distinguishes positron processes from other gamma emissions and enables identification in nuclear decay studies. The three-photon continuum contributes a broader low-energy tail below 511 keV, further confirming the positron origin when resolved.

Energetics and Kinematics

Energy Conservation

In positron emission, also known as beta-plus decay, energy conservation is governed by the mass-energy equivalence principle articulated by Einstein, where the rest energy of a particle is given by E = mc^2, with m as the rest mass and c as the speed of light. This relation underpins the energetics of nuclear decays, converting differences in atomic rest masses into kinetic energies of decay products. The total energy released, or Q-value, in positron emission is derived from the difference in rest masses of the parent and daughter atoms, accounting for the creation of the positron-electron pair. For a parent nucleus decaying as ^{A}_{Z}X \rightarrow ^{A}_{Z-1}Y + e^{+} + \nu_e, the Q-value is calculated using atomic masses m(^{A}_{Z}X) and m(^{A}_{Z-1}Y) to incorporate the electron shells properly, yielding: Q = \left[ m(^{A}_{Z}X) - m(^{A}_{Z-1}Y) - 2m_e \right] c^2, where m_e is the electron rest mass (0.511 MeV/c^2). This formula arises because the parent atom has Z electrons, while the daughter has Z-1 electrons plus the emitted positron (equivalent to an additional electron mass), necessitating the subtraction of $2m_e c^2 to balance the electron accounting; atomic binding energies are typically neglected as they are small compared to nuclear scales. The derivation starts with the total rest energy of the parent atom, subtracts the rest energies of the daughter atom and the positron-electron pair (since the neutrino is massless), and equates the difference to the total kinetic energy available to the products, ensuring energy conservation in the rest frame. For positron emission to be energetically feasible, the atomic mass-energy difference [m(^{A}_{Z}X) - m(^{A}_{Z-1}Y)] c^2 must exceed 1.022 MeV (twice the electron rest energy), which corresponds to Q > 0. If the atomic mass-energy difference is between 0 and 1.022 MeV, becomes the competing process, as it avoids creating an additional particle pair and thus requires less energy threshold. In the decay, the Q-value is partitioned among the kinetic energies of the , , and daughter nucleus in this process. The maximum kinetic energy is approximately Q, achieved when the carries zero energy and the is minimal; however, due to the continuous spectrum from sharing, the average kinetic energy is approximately Q/3. The nuclear energy is negligible for heavy nuclei but follows from , typically on the order of keV or less. To illustrate, consider a generic parent atom with atomic mass excess leading to Q = 3 MeV; the maximum positron energy is then approximately 3 MeV, with the average around 1 MeV, demonstrating how the formula quantifies energy availability without specific isotopic data.

Momentum and Thresholds

In positron emission, also known as β⁺ decay, momentum conservation requires that the vector sum of the momenta of the emitted positron (\vec{p}_e), the antineutrino (\vec{p}_\nu), and the recoiling daughter nucleus (\vec{p}_r) equals zero: \vec{p}_e + \vec{p}_\nu + \vec{p}_r = 0. This three-body decay process ensures that the total linear momentum of the system remains balanced, with the nucleus absorbing the opposite momentum to the lepton pair. Since the antineutrino's direction is uncorrelated with that of the positron and unobserved in typical experiments, the positron momentum exhibits a continuous distribution rather than discrete values, contributing to the characteristic broad spectrum observed in β⁺ decays. The recoil momentum of the daughter nucleus is given by \vec{p}_r = -(\vec{p}_e + \vec{p}_\nu), which depends on the combined momenta of the positron and antineutrino. For heavy nuclei, where the atomic mass is typically on the order of GeV/c² or more, this recoil momentum is negligible compared to the lepton momenta (often in the MeV/c range), allowing approximations that ignore nuclear motion in kinematic calculations. However, precise measurements, such as those in trapped ion experiments, can detect this recoil to infer antineutrino properties indirectly. The minimum energy threshold for β⁺ decay arises from the need to create the positron while conserving energy and accounting for atomic electron rearrangements; the parent-daughter mass difference must exceed 1.022 MeV, equivalent to twice the electron rest mass energy (2 × 0.511 MeV). Below this threshold, positron emission is kinematically forbidden, favoring alternative decay modes like . For decays with higher available energy (Q-value ≫ 0 MeV), relativistic effects become significant for the positron, which can achieve velocities approaching the (β ≈ 1). The positron's total energy is then E = \gamma m_e c^2, where \gamma = 1 / \sqrt{1 - \beta^2} is the , and its momentum follows p = \beta \gamma m_e c. These relativistic ensure proper energy-momentum balance in the three-body system. Additionally, the Coulomb interaction between the low-energy positron and the positively charged daughter nucleus introduces a repulsive barrier, distorting the positron wave function and altering the decay probability. This effect is quantified by the Fermi function F(Z, W), a relativistic correction factor that modifies the phase space integral in the β⁺ decay rate formula. For positrons, the repulsion reduces the emission probability at low energies (small momentum p) compared to the non-interacting case, shifting the spectrum toward higher momenta; this correction is particularly important for nuclei with high atomic number Z.

Examples and Isotopes

Common Positron-Emitting Nuclides

Positron-emitting nuclides are predominantly artificially produced isotopes utilized in , particularly (), due to their suitable half-lives and characteristics that allow for effective detection. These nuclides by emitting a (β⁺), which subsequently annihilates with an to produce two 511 keV gamma rays detectable by PET scanners. While natural positron emission is exceedingly rare, occurring in trace branches of long-lived isotopes, the majority of practical applications rely on short- to medium-lived artificial isotopes. A rare example of natural positron emission is (⁴⁰K), which has a of 1.252 × 10⁹ years and undergoes β⁺ decay to argon-40 (⁴⁰Ar) with a branching ratio of only 0.0010%, alongside dominant β⁻ and branches. This minor pathway contributes negligibly to environmental positron sources but exemplifies how proton-rich nuclei in isotopes can decay via emission. The following table summarizes key properties of common positron-emitting nuclides, focusing on those widely used in imaging. Properties include , β⁺ branching ratio, maximum (E_max), and stable daughter product. Data are drawn from evaluated decay databases and reflect standard values for these isotopes.
NuclideHalf-Lifeβ⁺ Branching Ratio (%)E_max (keV)Daughter Product
¹¹C20.4 min99.8960¹¹B
¹³N9.97 min99.81199¹³C
¹⁵O2.04 min99.91732¹⁵N
¹⁸F109.8 min96.7634¹⁸O
⁶⁸Ga67.8 min89.11899⁶⁸Zn
⁶⁴Cu12.7 h17.5653⁶⁴Ni
⁸²Rb1.27 min95.43378⁸²Kr
⁸⁹Zr78.4 h22.7897⁸⁹Y
Among these, carbon-11 (¹¹C), (¹³N), oxygen-15 (¹⁵O), and (¹⁸F) form a foundational set for due to their high β⁺ branching ratios and energies that balance short range in with sufficient detection ; for instance, ¹⁸F's 97% β⁺ branch and 634 keV E_max make it ideal for labeling biomolecules like FDG for glucose . Gallium-68 (⁶⁸Ga) is notable for its availability and 89% β⁺ branch, enabling on-site production for targeted diagnostics. (⁸²Rb), with its ultrashort , supports rapid cardiac studies via systems. Short-lived nuclides often participate in decay chains that facilitate sequential imaging or studies of dynamic processes. For example, oxygen-15 (¹⁵O) decays to stable nitrogen-15 (¹⁵N), but in practice, it can be part of transient chains involving carbon-15 (¹⁵C, half-life 2.45 s, 100% β⁺ to ¹⁵N), allowing for rapid positron-based measurements in studies. Emerging nuclides like (⁶⁴Cu), with its 12.7-hour and dual β⁺/β⁻ emissions, are gaining traction in 2025 for theranostic applications, combining (17.5% β⁺ branch, 653 keV E_max) with potential via its beta-minus decay to stable nickel-64 (⁶⁴Ni). Similarly, zirconium-89 (⁸⁹Zr) supports longer-term antibody-based due to its 78.4-hour and 22.7% β⁺ branch to stable yttrium-89 (⁸⁹Y). Cobalt-55 (⁵⁵Co), with a 17.5 h , 77% β⁺ branch, and 1500 keV E_max decaying to stable (⁵⁵Fe), is emerging for applications in as of 2025. These properties enable extended biodistribution tracking without excessive radiation dose from high-energy positrons.

Production Methods

Positron-emitting isotopes are predominantly produced using charged-particle accelerators, with cyclotrons serving as the primary method for generating short-lived radionuclides suitable for (). In this process, protons are accelerated to energies of 10-20 MeV and bombarded onto enriched materials to induce (p,n) or similar reactions, resulting in neutron-deficient nuclei that decay via positron emission. A representative example is the production of through the ^{18}O(p,n)^{18}F reaction, where a proton beam irradiates ^{18}O-enriched (typically >95% enrichment) in a small-volume , yielding up to several curies per irradiation with beam currents of 50-100 μA. The efficiency of cyclotron production hinges on nuclear reaction cross-sections, which vary with beam energy and target composition; for ^{18}O(p,n)^{18}F, the cross-section peaks at approximately 50-60 mbarn near 10 MeV, optimizing yields while minimizing competing reactions. Target materials are selected for high isotopic purity to enhance the desired isotope and reduce impurities, such as using gaseous ^{18}O for certain setups or solid metal foils for others like copper-64 via ^{64}Ni(p,n)^{64}Cu. Post-irradiation, chemical purification is essential, often employing distillation for volatile products or ion-exchange chromatography to isolate carrier-free isotopes, ensuring radiochemical purity exceeding 99% for clinical applications. Reactor-based methods, involving thermal followed by subsequent decays, are less common for positron emitters due to the neutron-rich nature of reactor products, but they are viable for specific cases like produced via the ^{63}Cu(n,γ)^{64}Cu reaction in high-flux s. These approaches typically require longer times and yield lower specific activities compared to accelerators, limiting their use to longer-lived isotopes. Alternative accelerator techniques include linear accelerators (linacs), which generate isotopes via photoneutron (γ,n) reactions from produced by beams on high-Z targets, offering advantages in beam handling for isotopes like ^{18}F without proton-induced impurities. For exotic positron emitters, heavy-ion reactions at facilities such as GSI Helmholtz Centre employ accelerated ions like ^{36}Ar on calcium targets to produce rare nuclides beyond routine needs, with yields guided by fusion-evaporation models. Modern production occurs at specialized facilities worldwide, including biomedical cyclotrons at national laboratories like Brookhaven and for high-volume PET isotopes, and research sites like CERN's ISOLDE for exotic variants using and fragmentation. As of 2025, advancements in compact cyclotrons, such as self-shielded models with energies up to 18 MeV, have proliferated in clinical settings, enabling decentralized, on-demand synthesis with improved automation and reduced operational costs.

Applications and Detection

Medical Uses

Positron emission tomography (PET) is a key technique that leverages the of positrons emitted from radioactive tracers to produce pairs of coincident 511 keV gamma rays, enabling three-dimensional of metabolic processes within the body. This coincidence detection by a ring of detectors allows for precise localization of annihilation events along lines of response, achieving a typical of 4-6 mm in clinical systems. The method's high sensitivity to tracer distribution makes it invaluable for visualizing physiological functions at the molecular level, far surpassing anatomical imaging modalities like CT or MRI in detecting early metabolic changes. In a standard PET procedure, a receives an intravenous injection of a positron-emitting radiotracer, followed by a 30-60 minute uptake period to allow distribution to target tissues. Scanning then occurs in a cylindrical equipped with detectors that capture the back-to-back gamma rays; data are acquired in mode to reject scattered events, forming sinograms that undergo image reconstruction using algorithms such as filtered back-projection or iterative methods like ordered subset expectation maximization (OSEM). Modern PET systems are often integrated with for correction and anatomical correlation, enhancing diagnostic accuracy without significantly extending scan times, which typically last 10-30 minutes. Common radiotracers include ¹⁸F-fluorodeoxyglucose (FDG), which accumulates in tissues with high glucose metabolism, such as malignant cells overexpressing glucose transporters. FDG-PET is widely used for cancer detection and staging, where hypermetabolic tumors appear as focal uptake hotspots. For neurodegenerative diseases, amyloid-binding tracers like ¹⁸F-florbetapir target beta-amyloid plaques in , aiding early diagnosis by quantifying plaque burden in brain regions like the and frontal cortex. Clinically, PET excels in for tumor staging, restaging, and assessing treatment response; for instance, FDG-PET/ demonstrates up to 96% accuracy in staging compared to 80% for alone. In , it evaluates myocardial viability by detecting FDG uptake in hibernating but viable , guiding decisions. Neurologically, PET supports dopamine transporter imaging with tracers like ¹⁸F-FDOPA for and metabolic profiling for focus localization. These applications reflect its broad adoption across these fields. Safety profiles are favorable due to the low administered doses (typically 5-10 mSv effective dose for PET alone) and short half-lives of isotopes like ¹⁸F (110 minutes), which limit and allow rapid clearance. Combined PET/CT scans may increase the total dose to around 15-20 mSv, comparable to a few years of natural , with risks minimized through optimized protocols and shielding.

Scientific and Industrial Applications

Positron emission particle tracking (PEPT), an adaptation of principles, enables non-invasive imaging of internal dynamics in opaque materials, facilitating defect detection in metals and . In , PEPT tracks radiolabeled inclusions in molten aluminum alloys, revealing their motion and distribution to assess material homogeneity and identify voids or impurities that compromise structural integrity. For research, PEPT visualizes particle mixing in lithium-ion slurries during production, optimizing uniformity and detecting aggregation defects that affect charge and cycle life. These applications leverage short-lived positron emitters like ^{18}F to label tracers, allowing high-resolution of defect propagation without disrupting the sample. In fundamental physics, positron emission from β⁺ supports precision measurements of angular correlations, testing the model's V-A interaction structure. Experiments on nuclei such as ^{21} quantify the β-ν through momentum spectra, achieving uncertainties below 1% to probe symmetries. At facilities like J-PARC, the JSNS² experiment utilizes signals from inverse β (ν̄_e + p → e⁺ + n) to detect sterile neutrinos, with correlated backgrounds from β⁺ s of isotopes like ^{16}N analyzed to refine limits. sources from β⁺ emitters also enable studies; in CERN's ALPHA experiment, s from ^{22} are accumulated in Penning traps and combined with antiprotons to form , allowing spectroscopic comparisons with for tests. Industrial applications employ positron-emitting tracers for flow visualization in complex systems. In pipelines, PEPT tracks single labeled particles through turbulent fluids, mapping velocity profiles and mixing efficiency in opaque conduits up to 150 diameter. For oil reservoirs, (PET) images ^{11}C-labeled CO₂ migration in fractured samples under reservoir conditions (up to 10 MPa), quantifying effective diffusion coefficients (2.2 × 10^{-8} m²/s) and preferential flow paths to optimize and . These techniques provide real-time, quantitative data on multiphase flows, improving process control in operations. Laboratory simulations of astrophysical phenomena use high-intensity lasers to replicate production in gamma-ray bursts (GRBs). At , petawatt lasers irradiate foils, generating relativistic electron- pair s, producing billions of positrons per shot to mimic GRB dynamics and test pair instability models. Such experiments validate observations from telescopes like Fermi, elucidating lines in GRB spectra. Emerging applications integrate positron annihilation spectroscopy (PAS) for defect analysis in quantum computing materials, such as silicon carbide. PAS probes vacancy-type defects by measuring positron lifetime shifts, identifying coherence-limiting traps at atomic resolution to guide material purification. In superconducting films for quantum processors, PAS detects oxygen vacancies influencing flux noise, enabling targeted annealing to extend qubit coherence times beyond 100 μs. This non-destructive method supports scalable quantum hardware development by prioritizing defect-free substrates.

References

  1. [1]
    11.4: Positron Emission - Chemistry LibreTexts
    Sep 23, 2022 · Positrons are formed when a proton sheds its positive charge and becomes a neutron, as shown below: ⁢ Again, in the nuclear equation for ...
  2. [2]
    DOE Explains...Beta Decay - Department of Energy
    In this form, the nucleus emits a neutrino and a positron (the antimatter form of an electron). This process changes a proton in the nucleus into a neutron.
  3. [3]
    Radioactive decay types article - Khan Academy
    In positron emission, a proton in a radionuclide nucleus is converted into a neutron. This process releases a positron and an electron neutrino. A positron is a ...<|control11|><|separator|>
  4. [4]
    Other types of radioactive decay - ARPANSA
    Positrons are emitted from some unstable isotopes that have too few neutrons to be stable. Positron emission is equivalent to the capture of an electron in ...Spontaneous fission · Neutron emission · Positron or beta plus (β+...
  5. [5]
    Electron-positron annihilation | Radiology Reference Article
    Sep 12, 2024 · Where e− is the electron, e+ is the positron and γ are gamma rays emitted. 511 keV is the approximate amount of energy created when an electron ...
  6. [6]
    Annihilation Gamma Ray - an overview | ScienceDirect Topics
    Annihilation gamma rays are emitted when a positron and electron annihilate, converting their mass into energy, producing two gamma rays of ~511 keV.
  7. [7]
    Positron emission tomography scan - Mayo Clinic
    Apr 16, 2025 · A positron emission tomography (PET) scan is an imaging test that can help reveal the metabolic or biochemical function of the body's tissues and organs.
  8. [8]
    Positron Emission Tomography (PET) | Johns Hopkins Medicine
    Positron emission tomography (PET) is a type of nuclear medicine procedure that measures metabolic activity of the cells of body tissues.
  9. [9]
    Positron emission tomography: An overview - PMC - NIH
    Molecular imaging using PET could provide quantitative estimation of biological and physiological processes in very early stages of disease progression. The ...
  10. [10]
    Nuclear Decay Pathways - Chemistry LibreTexts
    Jan 29, 2023 · The first type (here referred to as beta decay) is also called Negatron Emission because a negatively charged beta particle is emitted, whereas ...
  11. [11]
  12. [12]
    [PDF] Basic Health Physics - 01 - Introduction to Radioactivity and Radiation.
    Jan 18, 2011 · A positron is an antimatter electron “born” in the nucleus. It has the same mass as an electron but it has a positive charge. • Positron ...
  13. [13]
    What Is the Weak Force? | Live Science
    Dec 23, 2014 · In beta plusdecay, sometimes annotated as β+ decay, a proton decays into a neutron, a positron and a neutrino. One element can change into ...
  14. [14]
    [PDF] Weak Interactions
    The weak interaction is also responsible for the B-decay of atomic nuclei, which involves the transformation of a proton to a neutron (or vice versa). Examples.
  15. [15]
    Beta Decay
    Aug 9, 2000 · In all three processes, the number A of nucleons remains the same, while both proton number, Z, and neutron number, N, increase or decrease by 1 ...
  16. [16]
    Further Modes of Decay - Positron Emission and Electron Capture
    Jul 28, 2023 · Positron emission is common among isotopes having a low neutron-to-proton ratio. The second new method of decay is called electron capture. The ...
  17. [17]
  18. [18]
    Positively Perplexing Positrons | Los Alamos National Laboratory
    Jan 1, 2020 · Ten years ago, scientists observed something unexpected: an excess of positrons among cosmic rays. Where they're coming from is a galactic ...
  19. [19]
    Nuclear weak interaction rates in primordial nucleosynthesis - arXiv
    Sep 1, 2010 · We also compute the rates of positron and electron neutrino capture on 6He. We calculate beta and positron decay transitions where appropriate.
  20. [20]
  21. [21]
    [PDF] Physics, Chapter 45: Natural Radioactivity - UNL Digital Commons
    We may visualize the processes of positron emission and electron capture as being incidental to the transformation of a proton in the nucleus into a neutron.
  22. [22]
    [PDF] POSITRON-EMITTING RADIONUCLIDES - OSTI.GOV
    helium-3, and helium-4 to compatable energies. To date only 27 positron emitting radionuclides have been subjected to radiopharmaceutical consideration, whereas ...
  23. [23]
    The quantum theory of the electron - Journals
    Husain N (2025) Quantum Milestones, 1928: The Dirac Equation Unifies Quantum Mechanics and Special Relativity, Physics, 10.1103/Physics.18.20, 18. Shah R ...
  24. [24]
    The Positive Electron | Phys. Rev. - Physical Review Link Manager
    C. D. Anderson, Science 76, 238 (1932); C. D. Anderson, Phys. Rev. 43, 381A (1933). Outline Information. Citing Articles (459); Abstract; See Also; References.
  25. [25]
    Carl D. Anderson – Facts - NobelPrize.org
    By studying the tracks of cosmic ray particles in a cloud chamber, in 1932 Carl Anderson discovered a positively-charged particle with a mass seemingly equal to ...Missing: paper | Show results with:paper<|separator|>
  26. [26]
    The Neutrino Hypothesis - radioactivity.eu.com
    In 1930, the physicist Wolfgang Pauli solved the problem of the missing energy of beta decays by postulating the existence of a new particle.
  27. [27]
    [PDF] Detecting the Neutrino - UF Physics
    Beta decay following fission produces an electron antineutrino and this, interacting weakly with a proton, yields a positron and a neutron. Solar energy ...
  28. [28]
    A 'Forever' Stamp and a Discovery That Changed Physics Forever
    Mar 10, 2021 · They published a paper suggesting ways of testing for parity violation. Lee mentioned these ideas to Wu, his fellow professor at Columbia, ...
  29. [29]
    [PDF] The Discovery of Parity Violation
    PARITY | PARITY ... Expert in Beta Decay Spectroscopy. Collaborated with Lee & Yang to design an experiment: Tested the direction properties of Co-60 decay. Chien ...
  30. [30]
    Precise Shape Measurements of Beta Spectra of and | Phys. Rev.
    Precise measurements of the detailed shapes of the beta spectra of Y 9 1 and Y 9 0 were made in order to determine better to what extent the theory of beta ...Missing: 1970s | Show results with:1970s
  31. [31]
    [PDF] Ten Years of the Universal V-A Weak Interaction Theory and Some ...
    Most of the weak processes involve strongly interacting particles; hence the comparison of the experimental results with the predictions of the V-A theory ...Missing: positron | Show results with:positron
  32. [32]
    [PDF] Cyclotron Produced Radionuclides: Principles and Practice
    Many of these cyclotrons are dedicated to the production of isotopes for positron emission tomography (PET), more specifically, 18F for the production of ...
  33. [33]
    The Large Electron-Positron Collider - CERN
    The collider's energy eventually topped 209 GeV in 2000. During 11 years of research, LEP's experiments provided a detailed study of the electroweak interaction ...
  34. [34]
    Cyclotrons and positron emission tomography radiopharmaceuticals ...
    Positron-emitting radionuclides are commonly produced in charged particle accelerators, eg, linear accelerators or cyclotrons. The most widely available ...
  35. [35]
    New Precise Calculation of Nuclear Beta Decays Paves the Way to ...
    Mar 26, 2025 · In nuclear beta decay an up quark 'u' in a proton converts into an up down quark 'd,' turning the proton into a neutron and emitting a positron ...
  36. [36]
    US and Japan join forces to present some of the most precise ...
    Oct 22, 2025 · To study neutrino oscillation, the researchers produce neutrinos or antineutrinos of a specific flavor at the source of the experiments and then ...
  37. [37]
    State of the Art in Cyclotrons for Radionuclide Production in ...
    Jan 11, 2023 · This critical review presents the main manufacturers and briefly discusses the characteristics of the models they currently offer on the market.
  38. [38]
    Nuclear Experiment - Galileo
    The electron has a continuous energy spectrum because of the kinematics of a three body decay. A related process is the emission of a positron: p --> n + e+ + ν ...
  39. [39]
    [PDF] 2/4/09 - Chem 481 Lecture Material
    Feb 4, 2009 · Thus, positron decay is only possible if the decay energy exceeds 1.022 MeV. Note that 1.820 MeV + 1.022. MeV = 2.842 MeV, the decay energy ...
  40. [40]
    8.1 W and Z bosons - Particle physics - The Open University
    Figure 9 A beta-plus decay process involves the creation and disappearance of a W+ boson. An up quark decays into a W+ boson and a down quark. The W+ boson ...
  41. [41]
    [PDF] 22.101 Applied Nuclear Physics (Fall 2006) Lecture 22 (1
    Dec 4, 2006 · These two orientations will be called Fermi and Gamow-Teller respectively in what follows. In applying the conservation conditions, the goal ...
  42. [42]
    A.45 Fermi theory - FAMU-FSU College of Engineering
    Besides the spin and parity rules already mentioned, Fermi decays must satisfy the approximate selection rule that the magnitude of isospin must be unchanged.
  43. [43]
    CH103 - CHAPTER 3: Radioactivity and Nuclear Chemistry
    gamma (γ) decay which is characterized by the emission of ionizing radiation and does not contain mass or charge. positron (β+) emission which is a positron ...Missing: post- | Show results with:post-
  44. [44]
    [PDF] 34. Passage of Particles Through Matter
    Jun 1, 2020 · Electron (positron) scattering is considered as ionization when the energy loss per collision is below 0.255 MeV, and as Møller (Bhabha) ...
  45. [45]
    Positron physics
    The positron is stable in vacuum (average lifetime 1021 years), whereas in condensed matter it typically remains only a short time (10-10 sec) before ...Missing: s | Show results with:s
  46. [46]
    The 511 keV emission from positron annihilation in the Galaxy - arXiv
    Sep 23, 2010 · The first gamma-ray line originating from outside the solar system that was ever detected is the 511 keV emission from positron annihilation in the Galaxy.Missing: radiation evidence 1930s
  47. [47]
    [PDF] A Health Warning: Here are some summary notes to cover the nuclear
    In terms of atomic masses, the Q values of these three processes, for a parent x and daughter y, are given by: Qβ− = mx − my. 7. Page 8. Qβ+ = mx − my ...
  48. [48]
    Radioactivity | McGraw Hill's AccessScience
    For positron decay to occur, the total decay energy must exceed 1.022 MeV (twice the rest energy of the electron). The total decay energy for β+ decay is then E ...<|control11|><|separator|>
  49. [49]
    [PDF] Response to reviewers - GChron
    However, positron decay can only compete with the electron capture if the Q value of the electron capture decay itself is greater than the threshold 1022 MeV ...
  50. [50]
    [PDF] Positron Emission Tomography
    to a characteristic maximum, or endpoint, energy,. Emax; the associated average positron energy, E៮, is approximately one-third of its endpoint energy,. E ...
  51. [51]
    Q-Value Calculator (QCalc) - National Nuclear Data Center
    QCalc calculates Q-values for nuclear reactions or decay. It uses mass values from the 2020 Atomic Mass Evaluation by M. Wang et al.Missing: positron | Show results with:positron
  52. [52]
    β-decay angular correlations with neutral atom traps - IOPscience
    Oct 14, 2014 · Coincidences between the beta (β) and recoiling nucleus allow the determination of the neutrino (ν) momentum more directly than previously ...
  53. [53]
    [PDF] Basic Physics of Radionuclide Imaging - Stanford Medicine
    Unlike the other forms of beta decay, this reaction requires an external beam of neutrinos and thus is not relevant to medical nuclear emission imaging. In ...Missing: prevalence | Show results with:prevalence
  54. [54]
    [PDF] Review of formulas for relativistic motion
    Key formulas include β = v/c, γ = 1/√(1-β), Etotal = Erest + T, Etotal = γm0c², and p = γm0v = γm0βc.
  55. [55]
    [PDF] Beta decay
    Feb 28, 2011 · The positron spectra as a function of momentum for distorted waves are shifted to higher momenta by Coulomb repulsion. NUCS 342 (Lecture 16).
  56. [56]
    [PDF] Positron range estimations with PeneloPET - e-Archivo
    Table 1. Decay mode, half-life, maximum and mean kinetic energies (Emax and Emean respectively), and intensity of the annihilation photons emitted by the ...
  57. [57]
    The Branching Ratio of Potassium 40 | Phys. Rev.
    The branching ratio of potassium 40 has been measured by determining the argon and potassium content of potassium feldspars of accurately known ages.Missing: positron | Show results with:positron
  58. [58]
    [PDF] Production of Long Lived Parent Radionuclides for Generators
    Using a generator system, it is possible to obtain a radiochemically pure daughter radionuclide by adapting a suitable and efficient separation technique. The ...
  59. [59]
    An Imaging Comparison of 64Cu-ATSM and 60Cu-ATSM in Cancer ...
    With a half-life of 12.7 h, 64Cu is ideally suited for PET studies ... Moreover, because 64Cu has a maximum positron energy of 0.66 MeV, similar to ...
  60. [60]
    89 Zr-PET imaging in humans: a systematic review
    Sep 4, 2021 · The relatively low-energy of 89Zr-positrons (Eβ+,max = 897 keV; Eβ+,ave = 396.9 keV) leads to a maximum positron-range in water of 3.6 mm ...
  61. [61]
    Recent Advances in Zirconium-89 Chelator Development - PMC - NIH
    This review focuses on recent advances in zirconium-89 chelation chemistry and will highlight the rapidly expanding ligand classes that are under investigation ...
  62. [62]
    [18F]fluoride From a Small Cyclotron for the Routine Synthesis of ...
    [18F]Fluoride was produced via the 18O (p, n) 18F reaction using a low volume stainless steel 18O-water target in a small cyclotron.
  63. [63]
    [PDF] PET Radionuclides Production Cyclotron Selection and ... - AAPM
    18O(p,n)18F Cross Section. 400. 500 arn. ) 1 mbarn = 10-27 cm2. 0. 100. 200. 300. 0 ... * Typical production yields using >95% enriched 18O-Water. Ernest ...
  64. [64]
    Cyclotron produced F-18 radionuclide: O-18 enriched water ...
    The raw materials (enriched water) used in F-18 production would be required to be of certain specifications with an acceptable range of enrichment.
  65. [65]
    Positron-emitting isotopes produced on biomedical cyclotrons
    This review will discuss the production and applications of positron-emitting radionuclides for use in Positron Emission Tomography (PET)
  66. [66]
    [PDF] Copper-64 radiopharmaceuticals : production, quality control and ...
    Reactor production. Copper‑64 is producible in a nuclear reactor by thermal neutron capture,. 63Cu(n, γ)64Cu, or by fast neutron capture, 64Zn(n, p)64Cu [2–5].
  67. [67]
    Fast and easy reactor-based production of copper-64 with high ...
    This enables efficient 64Cu recovery through liquid–liquid extraction after neutron capture. The automatable process allows reuse of the target material and ...
  68. [68]
    Production Review of Accelerator-Based Medical Isotopes - PMC
    This paper reviews alternative production methods in the form of cyclotrons, linear accelerators and neutron generators.
  69. [69]
    Cross-sections for 43Sc, 44mSc, and 44gSc from two heavy ion ...
    Two different heavy ion reactions were used to produce 43Sc (t 1 2 = 3.891 h), 44 g Sc (t 1 2 = 4.042 h), and 44 m Sc (t 1 2 = 58.61 h) among other stable ...
  70. [70]
    Radioisotopes in Medicine - World Nuclear Association
    Jan 10, 2025 · The most common radioisotope used in diagnosis is technetium-99 (Tc-99m) accounting for about 80% of all nuclear medicine procedures and 85% of ...Missing: prevalence | Show results with:prevalence
  71. [71]
    Fighting Cancer on Earth and in Space Using High-Energy Protons
    Oct 25, 2022 · The Brookhaven Linac Isotope Producer, a linear proton accelerator for making medical isotopes at Brookhaven National Laboratory. This story ...<|control11|><|separator|>
  72. [72]
  73. [73]
    Positron Emission Tomography (PET)
    The spatial resolution of the PET images is typically ~4-5 mm, and the CT images is ~ 1 mm. This combined PET/CT scanner is a powerful tool for assessing ...
  74. [74]
    Clinical Applications of PET and PET-CT - PMC - PubMed Central
    PET scan detects the disease at the metabolic level while anatomical imaging techniques like CT or MRI detect the disease at the structural level. PET Tracers.Missing: principles | Show results with:principles
  75. [75]
    Brain PET in the Diagnosis of Alzheimer's Disease - PMC - NIH
    FDG-PET has been proven to be a promising modality for detecting functional brain changes in AD, identifying changes in early AD, and helping to differentiate ...
  76. [76]
    Positron Emission Tomography Scan Market Size, Share [2032]
    The global positron emission tomography scan market size is projected to grow from $19.31 billion in 2025 to $27.40 billion by 2032, exhibiting a CAGR of ...<|separator|>
  77. [77]
    EFFECTIVE RADIATION DOSE OF 18F-FDG PET/CT - PubMed
    Dec 31, 2019 · The results showed that an average radiation dose of 8.19 ± 0.83 mSv and 13.44 ± 5.14 mSv for the PET and CT components, respectively, ...
  78. [78]
    Cumulative radiation doses from recurrent PET–CT examinations
    The estimated mean effective dose for whole-body PET–CT amounted to 17.6 ± 8.7 mSv, in comparison to 3.6 ± 1.4 mSv for PET/MRI, resulting in a potential dose ...
  79. [79]
    A positron emission particle tracking (PEPT) study of inclusions in ...
    A model of inclusion behaviour in a flowing liquid Al alloy was also developed, and the Positron Imaging system described was used to validate this model.Missing: defect batteries
  80. [80]
    Use of Positron Emission Particle Tracking to Assess Mixing of a ...
    Positron emission particle tracking (PEPT) is a noninvasive technique capable of imaging the three-dimensional dynamics of a wide variety of powders ...
  81. [81]
  82. [82]
    Positrons - ALPHA Experiment - CERN
    The first ingredient that is needed to create antihydrogen are positrons. The Positron (= positive electron), e+, is the antimatter counterpart of the electron.Missing: research | Show results with:research
  83. [83]
    Integrated positron emission particle tracking (PEPT) and X-ray ...
    Aug 5, 2024 · A combined positron emission particle tracking (PEPT) and X-ray computed tomography (CT) technique is presented, and its utility is demonstrated through ...Missing: batteries | Show results with:batteries
  84. [84]
    Flow visualization of CO2 in tight shale formations at reservoir ...
    Aug 29, 2015 · Positron emission tomography successfully used to explicitly image CO2 flow in shale; Diffusion coefficient derived exclusively from PET ...
  85. [85]
    Illuminating the science of black holes and gamma-ray bursts using ...
    Feb 28, 2023 · High-power lasers now create record-high numbers of electron-positron pairs, opening exciting opportunities to study extreme astrophysical processes.
  86. [86]