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Tracheobronchitis

Tracheobronchitis is an acute inflammation of the trachea (windpipe) and bronchi (the major air passages leading to the lungs) in humans and animals, typically caused by viral or bacterial infections and lasting a few weeks.^[1] In animals, particularly dogs, it is known as kennel cough and is highly contagious in group settings.^[2] It is often synonymous with acute bronchitis and affects approximately 5% of adults annually, with most cases resolving without complications.^[1] The primary causes of tracheobronchitis are infectious agents, with about 95% of cases resulting from viruses such as those causing the common cold or influenza, while bacterial infections like Chlamydia pneumoniae account for roughly 5%.^[1] Noninfectious triggers include exposure to irritants such as cigarette smoke, dust, allergens, or chemical fumes, particularly in individuals with weakened immune systems or underlying respiratory conditions.^[3] In hospitalized or intubated patients, ventilator-associated tracheobronchitis can develop after 48 hours of mechanical ventilation, increasing the risk of progression to pneumonia due to bacterial colonization.^[1] Common symptoms include a persistent productive cough, sore throat, fatigue, runny nose, and mild fever, which usually peak within the first week and subside over 1–3 weeks.^[1] In more severe cases, patients may experience shortness of breath, wheezing, chest discomfort, or stridor (a high-pitched breathing sound), signaling potential airway obstruction.^[3] Diagnosis typically involves a physical examination, review of medical history, and, if needed, imaging like a chest X-ray to rule out pneumonia or other complications.^[1] Treatment focuses on symptom management and supportive care, as most viral cases resolve spontaneously without antibiotics.^[1] Over-the-counter remedies such as acetaminophen for pain and fever, increased fluid intake, rest, and humidified air can alleviate discomfort, while antibiotics are reserved for confirmed bacterial infections or secondary complications like pneumonia.^[3] In ventilator-associated cases, prompt antibiotic therapy is often necessary to prevent escalation to life-threatening pneumonia, with overall mortality rates of 20–50% in critically ill patients (as of 2021).^[4] Prevention strategies emphasize avoiding respiratory irritants and infections through measures like quitting smoking, reducing exposure to pollutants, practicing good hand hygiene, and staying up-to-date on vaccinations for influenza and other preventable respiratory viruses.^[3] Individuals at higher risk, such as those with chronic lung diseases or immunocompromised states, should consult healthcare providers for personalized preventive advice.^[1] Unlike chronic bronchitis, which involves persistent inflammation lasting at least three months per year for two consecutive years and is often linked to long-term irritant exposure, tracheobronchitis is generally self-limiting and does not lead to permanent damage in uncomplicated cases.^[3]

Definition and Overview

Definition

Tracheobronchitis is defined as the inflammation of both the trachea and the bronchi, the major conducting airways of the respiratory tract.^[5] The trachea, commonly referred to as the windpipe, is a flexible tube approximately 10-12 cm long that connects the larynx to the thoracic cavity and bifurcates at the carina into the right and left main bronchi, which then branch further to deliver air to the lungs.^[6]^[7] This inflammation typically manifests as an acute process that is self-limited, often resolving within 1 to 3 weeks with supportive care.^[8] Tracheobronchitis is typically acute and the most prevalent form, generally associated with transient episodes rather than persistent damage.^[3] Chronic forms, though less common, involve prolonged inflammation that may recur or persist over time and can overlap with chronic bronchitis. The term "tracheobronchitis" first appeared in medical literature in the mid-19th century; for instance, a 1932 study addressed it in relation to non-diphtheritic infections in children.^[9] Tracheobronchitis is distinguished from related conditions such as tracheitis, which is limited to inflammation of the trachea alone, and bronchitis, which primarily affects the bronchi without significant tracheal involvement.^[1] The condition occurs in both humans and animals; in dogs, it is known as canine infectious tracheobronchitis or kennel cough.^[10]

Pathophysiology

Tracheobronchitis involves inflammation of the trachea and bronchi, characterized by an initial irritation—often from infectious agents—that triggers a localized immune response. This leads to epithelial damage and inflammation, manifesting as mucosal edema and increased mucus production in the affected airways.^[8] These changes narrow the airway lumen and stimulate the cough reflex as a protective mechanism to expel irritants and excess secretions.^[11] In some cases, the damaged epithelium becomes susceptible to secondary bacterial invasion, potentially complicating the condition with superimposed infections, although the primary process remains driven by the initial insult.^[8] These alterations can lead to prolonged recovery if unresolved.^[11] The pathophysiology of acute tracheobronchitis is typically self-limited and reversible, with inflammation resolving within 1-3 weeks as the immune response clears the trigger and tissue repairs itself without lasting structural changes.^[8] Chronic forms, when they occur, feature persistent inflammation due to repeated insults, resulting in ongoing mucus hypersecretion and increased susceptibility to exacerbations, similar to chronic bronchitis.

Causes

Infectious Causes

Tracheobronchitis, also known as kennel cough in animals or acute bronchitis in humans, is primarily caused by infectious agents that target the upper and lower respiratory tract. In both humans and animals, viral pathogens are the most common initiators, often leading to primary infections that can predispose to secondary bacterial involvement. The condition is highly contagious and spreads efficiently in crowded or close-contact environments. In humans, common viral causes include rhinovirus, influenza viruses, parainfluenza viruses, and adenovirus, which account for the majority of acute tracheobronchitis cases, particularly during seasonal outbreaks.^[12] These viruses typically infect the epithelial lining of the trachea and bronchi, causing inflammation and excessive mucus production. Bacterial agents in humans are less frequent as primary causes but include Mycoplasma pneumoniae, which is implicated in up to 10-20% of community-acquired respiratory infections, and Bordetella pertussis, responsible for whooping cough that can manifest as tracheobronchitis.^[13] Secondary bacterial invaders, such as Streptococcus pneumoniae or Haemophilus influenzae, may complicate viral infections, exacerbating symptoms in vulnerable populations.^[11] In animals, particularly dogs, tracheobronchitis is often part of the canine infectious respiratory disease complex (CIRDC). Key viral agents include canine parainfluenza virus, canine adenovirus type 2, and canine distemper virus, which damage the respiratory mucosa and facilitate bacterial colonization.^[14] The primary bacterial pathogen is Bordetella bronchiseptica, a gram-negative bacterium that adheres to ciliated epithelial cells, causing paroxysmal coughing and present in up to 50-80% of kennel cough cases in unvaccinated dogs.^[15] Other bacterial contributors include Mycoplasma spp., such as Mycoplasma cynos, and secondary pathogens like Streptococcus spp. or Haemophilus spp., which thrive in the damaged airways post-viral infection.^[16] Transmission of these infectious agents occurs primarily through airborne droplets from coughing or sneezing, as well as direct contact with contaminated surfaces or fomites, making outbreaks common in settings like schools for humans or kennels and shelters for dogs.^[17] In canine cases, close confinement accelerates spread, with incubation periods of 3-10 days for most pathogens.^[18] Zoonotic potential is limited overall, but Bordetella bronchiseptica from infected pets can rarely transmit to immunocompromised humans, causing mild respiratory illness or, in severe cases, pneumonia.^[19] Other agents, such as canine distemper virus, pose no known risk to humans.^[14]

Non-Infectious Causes

Non-infectious causes of tracheobronchitis encompass environmental irritants, allergic responses, and mechanical or reflux-mediated factors that provoke inflammation in the trachea and bronchi without microbial involvement. These etiologies often manifest in acute exacerbations or contribute to chronic forms, particularly in susceptible individuals exposed to occupational or lifestyle risks. Environmental irritants, including cigarette smoke, air pollutants, dust, and chemical fumes, induce direct mucosal damage and inflammatory responses in the airways. For instance, tobacco smoke acts as a potent irritant, causing epithelial injury and increased mucus production that characterizes tracheobronchitis symptoms.^[11] Similarly, exposure to occupational toxins like ammonia vapors or industrial pollutants can trigger acute inflammation by irritating the respiratory epithelium, exacerbating underlying airway hypersensitivity.^[20] Air pollution from sources such as traffic emissions or biomass burning further contributes by promoting oxidative stress and bronchial edema.^[21] Allergic reactions play a significant role, particularly in individuals with hypersensitivity, where exposure to aeroallergens like pollen, dust mites, or pet dander leads to eosinophilic inflammation of the tracheobronchial mucosa. This process involves IgE-mediated mast cell degranulation, resulting in airway edema, bronchoconstriction, and cough-dominant symptoms akin to allergic bronchitis.^[22] Such reactions are more prevalent in atopic patients and can mimic infectious tracheobronchitis, often requiring differentiation through allergy testing.^[11] Other contributing factors include mechanical insults and underlying systemic conditions. Aspiration of foreign bodies, such as food particles or small objects, can obstruct and inflame the tracheobronchial tree, leading to localized irritation and secondary tracheobronchitis, especially in adults with altered swallowing.^[23] Trauma from prolonged endotracheal intubation causes mucosal injury and pseudomembrane formation, a non-infectious variant of tracheobronchitis observed in intensive care settings.^[24] Additionally, gastroesophageal reflux disease (GERD) promotes microaspiration of gastric acid into the airways, irritating the mucosa via chemical injury and vagally mediated reflexes, thereby increasing the risk of bronchitis-like inflammation.^[25] These non-infectious causes are more commonly associated with chronic tracheobronchitis or acute triggers in high-risk groups, such as smokers and those in polluted environments, accounting for a notable portion of cases beyond the predominant infectious etiologies.^[1]

Clinical Presentation

Symptoms in Humans

Tracheobronchitis in humans primarily manifests as a persistent cough, which may initially be dry and irritating before becoming productive with clear, white, yellow, or green mucus in about half of cases.^[11] This cough typically lasts 1 to 3 weeks, often intensifying at night and disrupting sleep.^[26]^[27] Associated symptoms commonly include a sore throat, low-grade fever or chills, chest discomfort or soreness from coughing, wheezing, shortness of breath, mild headache, body aches, and fatigue.^[21]^[11] These signs usually accompany an upper respiratory infection and contribute to overall malaise during the illness.^[26] The condition typically presents with acute onset following a viral upper respiratory infection, with symptoms peaking within the first 3 to 5 days before gradually subsiding over 1 to 3 weeks, resolving without scarring or permanent damage to the airways in most cases.^[11]^[21] In individuals with risk factors such as smoking or comorbidities like asthma, symptoms may be more severe, prolonged, or prone to complications, including exacerbated wheezing or secondary infections.^[11]

Symptoms in Animals

In dogs, tracheobronchitis, commonly known as kennel cough or canine infectious tracheobronchitis, primarily manifests as a harsh, dry cough often described as a "goose honk," which may be followed by retching and gagging and is easily induced by excitement, exercise, or gentle pressure on the trachea.^[28] Serous to mucopurulent nasal discharge and a mild fever are also frequent, with the condition often occurring in outbreaks among dogs in close quarters such as kennels or boarding facilities.^[29]^[30] The cough typically diminishes in severity within the first 5 days but can persist for 10 to 20 days, with few additional systemic signs in uncomplicated cases.^[29] Behavioral changes in affected dogs may include lethargy, reduced appetite, and exercise intolerance, particularly if secondary bacterial infections lead to bronchopneumonia.^[28] Small breeds, such as Chihuahuas, are more prone to prolonged symptoms due to anatomical factors like tracheal collapse, which can exacerbate airway irritation and delay recovery.^[31] In cats, tracheobronchitis is less common than in dogs and often presents with spasms of coughing that are most severe after periods of rest or at the onset of activity, accompanied by a slight fever.^[32] The acute phase typically lasts 2 to 3 days, but the cough may persist for several weeks.^[32] In horses, tracheobronchitis often occurs as part of the equine respiratory disease complex, triggered by viruses such as equine herpesvirus types 1 and 4, with symptoms including cough, serous nasal discharge, fever (up to 107°F or 41.7°C), malaise, pharyngitis, and inappetence.^[33] These signs usually appear 2 to 10 days after exposure and may progress to mucopurulent discharge if secondary bacterial infections develop.^[33]

Diagnosis

History and Physical Examination

The diagnosis of tracheobronchitis begins with a thorough history and physical examination to assess clinical features and identify potential risk factors. In humans, the history typically reveals an acute onset of cough following an upper respiratory infection, often lasting 1-3 weeks, with associated symptoms such as malaise, sore throat, and low-grade fever.^[11] Exposure history is crucial, including smoking, environmental irritants like pollution or allergens, and crowded settings that increase viral transmission risk; vaccination status, particularly for influenza, should also be evaluated as it may influence susceptibility.^[11] Physical examination in humans focuses on vital signs and respiratory assessment, revealing mild tachycardia, wheezing, or rhonchi on auscultation that may clear with coughing, alongside normal findings in other systems.^[11] Inspection may show signs of respiratory distress such as tachypnea or use of accessory muscles.^[11] Red flags include high fever exceeding 100.4°F (38°C), hemoptysis, or worsening shortness of breath, which suggest complications or alternative diagnoses requiring urgent evaluation.^[34]^[11] Differential diagnosis clues from history and examination help distinguish tracheobronchitis from pneumonia or asthma; for instance, the absence of high fever, crackles, or consolidation on exam points away from pneumonia, while a lack of atopy history or episodic triggers differentiates it from asthma.^[35] In animals, particularly dogs where tracheobronchitis is commonly known as kennel cough, the history emphasizes recent exposure to other dogs in high-risk environments like kennels, boarding facilities, or dog parks, with cough onset typically 5-10 days post-exposure.^[28] Vaccination status against key pathogens such as Bordetella bronchiseptica, canine parainfluenza virus, and distemper is essential to assess, as incomplete immunization heightens risk in group settings.^[36] Physical examination in dogs involves tracheal palpation to elicit a characteristic dry, honking cough, with auscultation often revealing normal or mildly harsh lung sounds without crackles in uncomplicated cases.^[28] Inspection may detect serous nasal discharge or mild respiratory effort, but affected animals are usually alert and active unless progression occurs.^[36] Red flags such as high fever, purulent discharge, lethargy, or productive cough signal potential secondary bacterial pneumonia needing further investigation.^[28] For differential diagnosis in animals, the paroxysmal nature of the cough induced by palpation, without systemic signs like depression or fever, helps rule out pneumonia (which features crackles and lethargy) or chronic conditions like asthma analogs, which may show more persistent wheezing without infectious exposure history.^[36]

Diagnostic Tests

Diagnosis of tracheobronchitis is typically clinical, based on history and physical examination, with laboratory and imaging studies used when needed to exclude differentials such as pneumonia if clinical findings are ambiguous or suggest complications.^[11] Chest radiography is a primary imaging modality, often revealing peribronchial thickening or increased bronchial markings without evidence of consolidation, which helps differentiate tracheobronchitis from pneumonia.^[37] In cases where pneumonia is suspected—such as in patients with high fever, tachypnea, or abnormal breath sounds—a chest X-ray is essential to rule out parenchymal involvement.^[38] Laboratory tests include complete blood count (CBC), which may demonstrate leukocytosis indicative of a bacterial component, though this is nonspecific.^[11] Polymerase chain reaction (PCR) assays on nasopharyngeal swabs or sputum detect viral or bacterial pathogens, such as Bordetella pertussis in humans or Bordetella bronchiseptica in dogs, providing etiologic confirmation.^[39] Sputum culture and Gram stain are performed in suspected bacterial cases to identify organisms and guide therapy, though routine use is limited in uncomplicated viral etiologies.^[37] In severe or persistent cases, bronchoscopy allows direct visualization of the trachea and bronchi, revealing inflammation or mucus accumulation, and facilitates sample collection for cytology or culture.^[34] For veterinary patients, particularly dogs with canine infectious tracheobronchitis, transtracheal wash or bronchoalveolar lavage yields samples for cytologic examination, revealing inflammatory cells, and subsequent PCR or culture to identify pathogens like Bordetella or canine parainfluenza virus.^[39] These tests are selected based on initial clinical history and examination findings to target suspected etiologies efficiently.^[38]

Management and Treatment

Supportive Therapy

Supportive therapy for tracheobronchitis focuses on alleviating symptoms and promoting recovery through non-pharmacological measures that maintain airway moisture, reduce irritation, and support overall comfort in both humans and animals.^[11]^[28] Adequate rest is essential, as it allows the body to direct energy toward healing inflamed airways, while encouraging sufficient fluid intake helps thin mucus secretions, facilitating easier clearance from the respiratory tract.^[38]^[40] In humans, patients are advised to drink plenty of water or clear fluids, aiming for at least 8-10 glasses daily unless contraindicated, to prevent mucus from becoming thick and obstructive.^[38] Similarly, in dogs with canine tracheobronchitis (often called kennel cough), owners should ensure access to fresh water and monitor intake to avoid dehydration, which can exacerbate coughing.^[28] Avoiding environmental irritants, such as smoke, dust, or strong odors, is crucial for both species to minimize further airway inflammation and support natural resolution of symptoms.^[38] Humidification plays a key role in soothing irritated airways by adding moisture to inspired air, which can reduce coughing and improve mucociliary clearance.^[41] In humans, steam inhalation from a hot shower or the use of a cool-mist humidifier in the bedroom helps maintain airway hydration, particularly during dry seasons or in arid climates.^[38] Nebulized saline may also be employed under medical guidance to deliver targeted humidity directly to the bronchi.^[41] For dogs, exposing the animal to steam—such as sitting in a bathroom during a hot shower for 10-15 minutes several times a day—effectively thins mucus and eases breathing without specialized equipment.^[42] These methods are particularly beneficial in mild cases, where they can shorten symptom duration by promoting expectoration of secretions.^[28] Cough management in supportive therapy emphasizes gentle, natural approaches to suppress irritation while allowing productive clearance. In humans over one year of age, a teaspoon of honey taken alone or in warm tea before bedtime can soothe the throat and reduce cough frequency, with studies showing it outperforms some over-the-counter remedies for nocturnal symptoms associated with upper respiratory infections.^[43]^[44] Honey is contraindicated for infants under one year due to the risk of botulism from bacterial spores.^[45] Environmental controls are vital for contagious forms, such as isolating affected individuals or animals to prevent spread; in veterinary settings, separating dogs with kennel cough for 1-2 weeks and disinfecting areas with bleach solutions helps contain outbreaks.^[46] These strategies complement any antimicrobial treatments by addressing symptomatic relief universally.^[11] Close monitoring is necessary to detect complications early, ensuring timely escalation of care. In humans, signs of dehydration—such as dry mouth, reduced urine output, or dizziness—warrant immediate medical attention, especially in children or those with persistent fever, as tracheobronchitis can lead to fluid loss from increased respiratory effort.^[47]^[48] For dogs, owners should watch for lethargy, refusal to eat, or sunken eyes indicating dehydration, consulting a veterinarian if symptoms worsen beyond 7-10 days or if breathing becomes labored.^[49] Regular assessment of vital signs, including respiratory rate and hydration status, helps prevent progression to secondary issues like pneumonia in vulnerable patients.^[28]

Specific Treatments

Specific treatments for tracheobronchitis target the underlying etiology, primarily infectious agents, and are selected based on clinical presentation, diagnostic findings, and patient population (human or animal). In bacterial cases, antimicrobials are employed judiciously to avoid promoting resistance, given the often self-limiting nature of the condition. For instance, in humans with suspected atypical bacterial pathogens such as Mycoplasma pneumoniae, Chlamydophila pneumoniae, or Bordetella pertussis, antibiotics like azithromycin (500 mg on day 1, followed by 250 mg daily for 4 days) or doxycycline (100 mg twice daily for 7-10 days) may be prescribed, potentially reducing cough duration by about 0.58 days on average, though evidence of significant benefit is limited.^[8] In severe bacterial tracheitis, particularly in children, initial airway management with intubation (required in 38-100% of cases) and ICU monitoring is essential to secure the airway and facilitate suctioning of purulent secretions, followed by broad-spectrum intravenous antibiotics such as ceftriaxone combined with clindamycin to cover pathogens like Staphylococcus aureus or Streptococcus, with a 10-14 day course to ensure resolution.^[34] Antivirals are rarely used outside of confirmed influenza-associated tracheobronchitis, where oseltamivir (75 mg twice daily for 5 days in adults) can shorten symptom duration by approximately 1 day if initiated within 48 hours of onset.^[11] For ventilator-associated tracheobronchitis (VAT) in intubated patients, treatment involves prompt initiation of systemic antibiotics targeting common pathogens such as Pseudomonas aeruginosa or Acinetobacter spp., typically with combinations like vancomycin plus piperacillin-tazobactam for 7-14 days, alongside continued mechanical ventilation support and surveillance cultures to prevent progression to ventilator-associated pneumonia.^[50] In veterinary medicine, particularly for canine infectious tracheobronchitis (kennel cough) involving Bordetella bronchiseptica or Mycoplasma spp., doxycycline remains the first-line antimicrobial at 5 mg/kg orally every 12 hours or 10 mg/kg every 24 hours for 7-10 days, due to its efficacy against these agents and good tolerability in dogs.^[51] Amoxicillin-clavulanate (11-22 mg/kg orally every 12 hours) serves as an alternative for secondary bacterial infections.^[51] Protocols emphasize empirical use only in cases with fever, lethargy, or mucopurulent discharge, with an initial 10-day observation period recommended for mild cases to minimize antibiotic overuse, as the condition is frequently viral and self-resolves.^[51] Bronchodilators, such as inhaled albuterol (via nebulizer or metered-dose inhaler), are indicated for patients exhibiting wheezing or airflow obstruction, providing symptomatic relief in subsets with bronchial hyperresponsiveness, though they do not shorten overall illness duration in uncomplicated cases.^[11] Anti-inflammatory agents like systemic corticosteroids (e.g., prednisone 40-60 mg daily for 5 days in adults) may be considered for severe inflammation or in patients with underlying conditions like asthma or COPD, but inhaled corticosteroids lack supporting evidence for routine use.^[8] Cough suppressants, such as dextromethorphan, are used cautiously in humans to alleviate severe, non-productive cough, but antihistamines and other antitussives offer no proven benefit and may exacerbate mucus retention.^[8] In veterinary settings, similar bronchodilators and anti-inflammatories are applied selectively for symptomatic control, complementing supportive measures like hydration.^[51]

Prevention

Measures in Humans

Preventing tracheobronchitis in humans primarily involves strategies to reduce exposure to respiratory viruses and irritants, as the condition is most often caused by viral infections such as influenza or rhinovirus.^[21] Good hygiene practices are foundational, including frequent handwashing with soap and water for at least 20 seconds, especially after contact with public surfaces or individuals showing respiratory symptoms.^[52] Additionally, covering the mouth and nose with a tissue or elbow when coughing or sneezing, and avoiding close contact with people who have colds or flu, helps limit viral transmission, particularly during peak respiratory seasons like winter.^[21] Staying home when ill further prevents spreading pathogens to others.^[52] Lifestyle modifications play a key role in lowering risk, with smoking cessation being one of the most effective measures, as tobacco smoke irritates the tracheobronchial mucosa and increases susceptibility to infections.^[11] Annual influenza vaccinations are strongly recommended for all adults, as flu viruses trigger many cases of acute tracheobronchitis; these shots can reduce infection rates by 40-60% in vaccinated populations.^[53] For broader protection, updated COVID-19 vaccines are recommended for all eligible individuals, while RSV vaccines are advised for adults aged 75 and older, adults aged 60-74 at increased risk for severe RSV, and pregnant people at 32-36 weeks gestation to protect infants, especially since these infections can mimic or lead to tracheobronchitis symptoms.^[54] Environmental controls are essential for minimizing irritants that exacerbate or precipitate the condition. Using air purifiers or HEPA filters can help reduce indoor allergens, dust, and pollutants, thereby decreasing airway inflammation in susceptible individuals.^[22] Prompt treatment of gastroesophageal reflux disease (GERD) is also important, as chronic acid reflux can irritate the throat and bronchi, heightening bronchitis risk; management with proton pump inhibitors or lifestyle changes like elevating the head during sleep is beneficial.^[21] For high-risk groups such as the elderly or immunocompromised, annual influenza vaccinations are particularly emphasized, along with pneumococcal vaccines to prevent secondary bacterial complications.^[21] These individuals should also prioritize avoiding crowded indoor spaces during outbreak seasons.^[55]

Measures in Animals

Prevention of tracheobronchitis in animals primarily relies on vaccination protocols tailored to high-risk environments such as kennels and boarding facilities. For dogs, the Bordetella bronchiseptica vaccine is a key component, available in intranasal, injectable, or oral forms, with intranasal administration preferred in shelters for its rapid onset of immunity within days.^[56]^[57] This noncore vaccine is often incorporated into the puppy vaccination series starting at 6-8 weeks of age, with boosters recommended every 6-12 months for dogs in social settings, alongside core vaccines like those for distemper, adenovirus-2, and parainfluenza virus that provide partial protection against the canine infectious respiratory disease complex (CIRDC).^[29] Quarantine and isolation are essential to curb transmission in group housing. Newly introduced dogs in boarding facilities or shelters should be quarantined for at least 14 days or until fully vaccinated to prevent introducing the pathogen, while symptomatic animals require immediate isolation in separate areas to avoid aerosol spread.^[58]^[14] Disinfection protocols involve thorough cleaning of affected areas with effective agents like diluted bleach (1:32 ratio), followed by drying, as the bacteria and viruses can persist on surfaces; facilities should maintain dedicated quarantine rooms with separate ventilation and entry points.^[59]^[46] Herd management strategies focus on minimizing stress and exposure in collective settings like kennels or farms. Avoiding overcrowding reduces direct contact and aerosol transmission, with recommendations to limit group sizes, ensure adequate space (at least 12 square feet per dog in shelters), and optimize ventilation, temperature, and humidity to bolster respiratory health.^[60]^[61] These practices, combined with routine health screening, help achieve herd immunity thresholds through widespread vaccination.^[62] In cats, tracheobronchitis often occurs as part of feline upper respiratory infections caused by viruses such as feline herpesvirus-1 (FHV-1) and feline calicivirus (FCV). Prevention centers on core vaccination with the FVRCP vaccine, which protects against FHV-1, FCV, and panleukopenia, typically administered starting at 6-8 weeks of age with boosters every 1-3 years depending on risk. Non-core vaccines for Chlamydia felis may be considered in multi-cat environments. Additional measures include quarantining new cats for 1-2 weeks, maintaining good hygiene to reduce stress and bacterial overgrowth, and avoiding overcrowding in catteries or shelters.^[63] In other species, such as horses, prevention targets related respiratory viruses causing similar upper airway inflammation. Vaccines against equine influenza virus, equine herpesvirus-1 and -4, and Streptococcus equi (strangles) are recommended, with boosters every 6 months for at-risk horses per American Association of Equine Practitioners guidelines, alongside biosecurity measures like avoiding communal water sources.^[64]^[65]

Prognosis and Complications

Tracheobronchitis is generally self-limiting with a favorable prognosis in most cases. In humans, the condition typically resolves within 1–3 weeks without specific treatment, particularly when caused by viral infections. Recovery is usually complete, with no long-term damage in uncomplicated cases. However, prognosis may be poorer in vulnerable populations, such as young children, older adults, or those with underlying conditions like chronic obstructive pulmonary disease (COPD) or immunosuppression, where symptoms may persist longer or lead to secondary issues.^[1]^[11] In animals, particularly dogs affected by infectious tracheobronchitis (commonly known as kennel cough), the prognosis is also excellent for healthy individuals, with most recovering fully within 7–14 days through supportive care. Puppies, senior dogs, or those with compromised immune systems face higher risks of prolonged illness.^[66]^[28] Complications are uncommon in otherwise healthy individuals but can occur, especially in severe or untreated cases. In humans, the most frequent complication is secondary bacterial pneumonia, which develops when the infection spreads to the lung parenchyma. This risk is elevated in ventilator-associated tracheobronchitis (VAT), where bacterial colonization can progress to ventilator-associated pneumonia (VAP), associated with mortality rates of 5–10% in intensive care settings. Rare complications include acute respiratory distress syndrome (ARDS), respiratory failure, and exacerbation of preexisting respiratory conditions. Recurrent episodes may contribute to the development of chronic bronchitis over time.^[1]^[11]^[22] In animals, complications primarily involve progression to bronchopneumonia, particularly in young or debilitated dogs, which can lead to dehydration, lethargy, and in severe cases, respiratory distress requiring hospitalization. Chronic bronchitis may develop in older or repeatedly exposed animals. Early intervention typically prevents these outcomes.^[66]^[28]

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GERD can cause various pulmonary manifestations: Chronic cough, bronchial asthma, bronchitis, pneumonia and interstitial fibrosis.
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The prominent clinical sign of kennel cough is a cough that sounds like a "goose honk" that may be followed by retching and gagging. The cough is easily induced ...
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Tracheobronchitis is a sudden or longterm inflammation of the trachea and bronchial airways; it may also extend into the lungs.
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* Coughing along with gagging or retching behavior seems to be the most con- sistent clinical sign of ITB. ' Nasal discharge is less fre- quently evident. ...
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Fever, nasal discharge, malaise, pharyngitis, and cough are key symptoms. ... tracheobronchitis. The natural reservoir of both EHV-1 and EHV-4 is the ...
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Nosocomial outbreak of serious canine infectious tracheobronchitis (kennel cough) caused by canine herpesvirus infection. J Clin Microbiol. 2010;48:1176 ...Canine Infectious... · Canine Influenza Virus · Canine Parainfluenza Virus<|control11|><|separator|>
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Evaluation for noninfectious causes of chronic cough, such as asthma (including cough-variant asthma), postnasal drip, and gastroesophageal reflux disease ...
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(Canine Infectious Tracheobronchitis) ... Kennel cough results from inflammation of the trachea. It is a mild, self-limiting disease but may progress to ...Missing: definition | Show results with:definition
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Results indicate a potential advantage of hydration with heated and humidified air over the conventional nebulization of cold saline solution after a ...
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Several studies focusing on the common cold suggest that honey may help calm coughs in adults and children over 1 year of age.
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A single dose of honey before bedtime was shown in recent studies to diminish cough and the discomfort experienced by children and their parents.
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Laryngotracheobronchitis, as the name implies, refers to inflammation of the larynx, trachea, and bronchi. Cases of laryngotracheobronchitis can be more severe ...
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Canine influenza | American Veterinary Medical Association
What are the signs of canine influenza? · Persistent cough · Thick nasal discharge · Fever (often 104-105oF) · Lethargy · Runny eyes · Reduced appetite.
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For shelters, intranasal (IN) Bordetella vaccine is recommended due to its single dose, rapid immunity, and bivalent/trivalent options. SQ requires two doses.
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• Quarantine exposed dogs for 14 days after treatment begins. • If neither isolation nor quarantine are an option, the only other humane alternative is.
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The most effective way is to prevent crowding by practicing sound population management strategies that decrease each animal's length of stay in the shelter.
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Some examples of canine diseases are parvo, infectious tracheobronchitis ... Overcrowding should be viewed as a serious shelter problem to be avoided ...
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[PDF] 2022 AAHA Canine Vaccination Guidelines
Vaccines have mitigated the impact of infectious diseases on populations through herd immunity so successfully that some dog owners may hold the perception that.
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