Fact-checked by Grok 2 weeks ago

Locoweed

Locoweed refers to about 20-25 species of perennial herbaceous plants primarily in the genera Astragalus and Oxytropis within the Fabaceae family, characterized by pinnately compound leaves, pea-like flowers in shades of purple, blue, white, or yellow, and growth in tufts or clumps typically 4 to 24 inches tall.^[1]^[2] These plants are native to arid, semiarid, and mountainous regions across the western United States, including states like Colorado, Utah, New Mexico, and Arizona, where they thrive in diverse soils from clay and sand to selenium-rich areas, often associated with sagebrush, pinyon-juniper woodlands, or cheatgrass communities.^[3]^[1]^[2] Notable for their toxicity, locoweeds contain the indolizidine alkaloid swainsonine—produced by endophytic fungi—which inhibits enzymes essential for glycoprotein processing, leading to a condition known as locoism or locoweed poisoning in grazing livestock such as cattle, sheep, horses, and goats.^[2] Symptoms of locoism typically emerge after 2 to 3 weeks of continuous ingestion and include neurological disorders like depression, ataxia, irregular gait, aggression, and "crazy" behavior—hence the name derived from the Spanish word loco meaning mad—along with emaciation, reproductive failures such as abortions and birth defects, and in severe cases, congestive heart failure or death.^[1]^[3]^[2] All plant parts are toxic year-round, though palatability is highest in spring, fall, and winter, and toxicity may slightly decrease after seed dispersal in summer; no effective treatments exist, making prevention through grazing management and herbicides like clopyralid or picloram critical for ranchers.^[1]^[3] Despite their dangers, some locoweed species play ecological roles, such as nitrogen fixation in soils, and certain non-toxic milkvetches (e.g., Astragalus cicer) are cultivated as forage, highlighting the need to distinguish between poisonous and beneficial relatives in rangeland management.^[3] Seeds of locoweed can remain viable in the soil for over 50 years, contributing to their persistence in infested areas across their wide distribution from southwestern South Dakota to Texas and from British Columbia to Mexico.^[1]

Background

History and Etymology

The term "locoweed" originates from the Spanish word "loco," meaning "crazy" or "insane," which describes the erratic and abnormal behavior exhibited by livestock poisoned by these plants.^[1] Early observations of this condition, known as locoism, were reported during Spanish colonial explorations in the southwestern United States in the 16th century, where explorers noted similar symptoms in their horses.^[4] As European settlers expanded westward in the 19th century, reports of locoism in cattle and sheep became more frequent, highlighting the plant's impact on rangeland grazing.^[5] The first technical account of locoism in English was published in 1873 in the Year Book of Agriculture, marking a formal recognition of the poisoning syndrome in the United States and prompting further investigations into its causes.^[6] For over a century, the exact toxin responsible remained unidentified, with early studies attributing symptoms to various factors before focusing on plant alkaloids. Between 1979 and 1982, researchers including Ralph Molyneux and Lynn F. James identified swainsonine, an indolizidine alkaloid, as the primary toxin in North American locoweeds, confirming its role in inducing locoism through biochemical analysis of species like Astragalus lentiginosus.^[7] This discovery built on prior isolation of swainsonine from Australian plants and established the foundation for understanding the toxin's effects on lysosomal enzymes. Swainsonine remains the key alkaloid associated with locoweed toxicity. In 2000, a significant outbreak of locoism was reported in Patagonia, Argentina, where Astragalus pehuenches caused the deaths of 220 out of 300 Merino sheep (73% mortality) over two months, with clinical signs including ataxia, blindness, and recumbency; this event represented one of the earliest documented cases of swainsonine-related poisoning in South America.^[8]

Taxonomy

Locoweed collectively refers to certain perennial herbaceous plants in the family Fabaceae that produce the indolizidine alkaloid swainsonine, which defines their inclusion in this toxic group and distinguishes them from non-toxic or differently toxic relatives. The primary genera are Astragalus (milkvetches) and Oxytropis (crazyweeds), both within the subfamily Faboideae. In North America, approximately 13 species of Astragalus (representing 48 taxa) and 4 species of Oxytropis (representing 5 taxa) have been confirmed to contain swainsonine, totaling 17 species (53 taxa) associated with locoism.^[5]^[9] Surveys continue to refine these numbers; a 2016 mass spectrometry analysis confirmed swainsonine in these taxa.^[5] Among the key North American species, Oxytropis sericea (white locoweed) is a silvery-haired perennial native to the Rocky Mountains and Great Plains, noted for its dense white hairs and swainsonine content up to 0.3% dry weight in some populations. Astragalus lentiginosus (freckled or spotted milkvetch) occurs in arid regions of the southwestern United States, with variegated pods and confirmed swainsonine production in multiple varieties. Astragalus mollissimus (woolly locoweed) is a low-growing plant with woolly stems and leaves, prevalent in Colorado and Utah, where it has been linked to significant livestock poisoning due to its high swainsonine levels. These species exemplify the toxic subset within their genera, as not all Astragalus or Oxytropis produce the alkaloid.^[2]^[10] Outside North America, swainsonine production occurs in other genera, such as Swainsona in Australia, where species like Swainsona galegifolia (smooth darling pea) contain the toxin and cause similar neurological effects in grazing animals. In South America, certain Ipomoea species in the Convolvulaceae family, including Ipomoea carnea, mimic locoweed toxicity through swainsonine synthesized by fungal endosymbionts, though they are not true legumes. These non-Fabaceae producers highlight the broader distribution of swainsonine but are often distinguished from classic locoweeds by their floral and growth characteristics.^[11]^[12]^[13] Swainsonine in locoweeds is frequently produced by vertically transmitted fungal endophytes rather than the plants themselves, including species like Embellisia spp. (now classified under Undifilum) in Astragalus and Oxytropis, which colonize seeds and tissues without causing disease. Additionally, Rhizoctonia leguminicola in certain legumes serves as an alternative source of swainsonine, though it is more commonly associated with other toxins. These symbiotic fungi underscore that "locoweed" taxonomy emphasizes swainsonine presence over strict botanical lineage.^[14]^[15]^[16] True locoweeds must be differentiated from similarly named but non-swainsonine plants, such as selenium-accumulating Astragalus species (e.g., A. bisulcatus), which cause selenosis through mineral hyperaccumulation rather than alkaloid toxicity, or Datura spp. (jimsonweed) in the Solanaceae family, which produce tropane alkaloids leading to anticholinergic poisoning. This distinction is critical for accurate identification in rangeland management, as only swainsonine producers induce the specific locoism syndrome.^[9]^[2]

Ecology and Distribution

Habitat and Growth

Locoweed species, primarily within the genera Astragalus and Oxytropis, exhibit a strong preference for open prairies, foothills, semiarid deserts, and well-drained soils such as sandy, gravelly, or decomposing granite substrates across the western United States.^[9]^[10] These plants are commonly found in diverse rangeland communities, including shortgrass prairies, desert shrublands, sagebrush steppes, pinyon-juniper woodlands, and mountain grasslands, often at elevations ranging from 1,600 to 11,000 feet.^[17]^[10] Approximately 21 species are associated with locoism due to their production of the toxin swainsonine, with concentrations highest in intermountain and southwestern rangelands.^[9] Most locoweeds display a perennial or short-lived perennial growth habit, characterized by a persistent root crown and taproot system that enables survival in harsh environments.^[9] Growth typically initiates in late fall, winter, or early spring, with vegetative development and flowering peaking during spring and fall seasons when soil moisture is available following precipitation events.^[17] Population dynamics are closely linked to climatic cycles, with outbreaks occurring in wet years that promote germination from persistent seed banks, while prolonged droughts lead to die-offs of annual and biennial forms.^[9] Long-lived perennials, such as white locoweed (Oxytropis sericea), can persist for many years in rocky or gravelly sites, producing seeds annually to replenish soil reserves.^[17] These plants are well-adapted to arid conditions through several key traits, including deep taproots that can extend up to 2-3 feet (0.6-0.9 meters) to access groundwater, silvery or woolly pubescence on leaves that minimizes transpiration and water loss, and symbiotic nitrogen fixation with rhizobial bacteria as members of the Fabaceae family.^[18]^[19]^[9] Such adaptations allow locoweeds to thrive in nutrient-poor, drought-prone soils where other vegetation struggles. During early growth stages in spring and fall, locoweeds offer higher nutritional value and palatability compared to dormant mature grasses, prompting selective grazing by livestock and exacerbating their problematic status in rangelands.^[10]^[20]

Geographic Range

Locoweed species, primarily within the genera Astragalus and Oxytropis, are predominantly native to western North America, spanning from southwestern South Dakota southward to Texas and New Mexico, and extending westward through the Rocky Mountains, encompassing mountainous terrain, foothills, and plains.^[1] These plants pose significant risks to livestock grazing in these regions due to their prevalence in rangelands.^[9] Within the United States, hotspots for locoweed occurrence include the Intermountain West, such as Utah, Colorado, and Wyoming, where species like Oxytropis sericea are common; the southwestern deserts of Arizona and New Mexico; and the edges of the Great Plains.^[9]^[1] These areas represent native distributions where locoweeds thrive and contribute to agricultural challenges through forage contamination.^[10] Globally, extensions of locoweed-like toxicity occur beyond North America, with Oxytropis species native to the Old World, including temperate and subarctic regions of Asia (such as China, Mongolia, and Russia) and Europe.^[21]^[22] In South America, Astragalus pehuenches is native to the Patagonian steppes of Argentina, where it caused a notable outbreak in 2000, resulting in the deaths of 220 out of 300 Merino sheep in a flock.^[8] Additionally, Swainsona species, which produce similar toxins, are endemic to Australian rangelands across all mainland states and territories.^[11] Introduced or analogous toxic plants include Ipomoea species, such as I. carnea, which mimic locoism symptoms through swainsonine production and occur in Africa and South America, often expanding in overgrazed tropical and subtropical areas without widespread invasiveness elsewhere.^[23]^[24] Locoweeds generally thrive in temperate to arid climatic zones characterized by cold winters and dry summers, with distribution limited by excessive moisture or shading.^[1]^[9]

Toxins and Biochemistry

Swainsonine Production

Swainsonine, the primary toxin responsible for locoism in livestock, is predominantly synthesized by fungal endophytes rather than directly by locoweed plants themselves. In species of Oxytropis, the endophyte Undifilum oxytropis produces swainsonine through a piperidine alkaloid biosynthetic pathway derived from lysine, involving key enzymes such as saccharopine dehydrogenase, saccharopine oxidase, and piperideine-6-carboxylate reductases, as identified in genomic analyses of the fungus. Similarly, in Astragalus species, endophytes from the Alternaria section Undifilum (e.g., Alternaria oxytropis) carry homologous gene clusters (e.g., swn genes) that facilitate swainsonine production via the same pathway, with vertical transmission ensuring high infection rates of 90-100% in toxic populations. Other fungi, such as Alternaria gansuense (synonym Embellisia astragali), have been associated with swainsonine production in certain Astragalus species like A. adsurgens, though these are less widespread than Undifilum symbionts. Swainsonine concentrations vary significantly within locoweed plants, typically ranging from 0.001% to 0.37% dry weight, with the highest levels (up to 0.3-0.5% in some Astragalus varieties like A. wootonii) found in seeds, flowers, and young vegetative growth. These levels are influenced by environmental factors, including plant stress such as drought or nutrient deficiency, which can elevate toxin production; seasonal patterns, with peaks during active growth in spring and fall when locoweeds are green and preferred by grazing animals; and endophyte load, where higher fungal colonization correlates directly with increased swainsonine output. For instance, cool-season locoweeds exhibit elevated concentrations during early spring regrowth and autumn resumption after summer dormancy. The symbiosis between locoweed plants and swainsonine-producing endophytes is often characterized as a defensive mutualism, where the alkaloid deters herbivory by insects and vertebrates, providing indirect benefits to the host plant in arid environments, though the resulting toxicity to livestock is an incidental consequence rather than an adaptive trait for the plant-fungus interaction. Quantification of swainsonine in plant material is commonly achieved through high-performance liquid chromatography (HPLC) coupled with evaporative light-scattering detection (ELSD) or mass spectrometry, or enzyme-linked immunosorbent assay (ELISA) for rapid screening, enabling detection limits as low as 0.001% dry weight.

Mechanism of Action

Swainsonine, the primary toxin in locoweed, exerts its toxic effects by acting as a potent inhibitor of α-mannosidase enzymes, specifically lysosomal α-mannosidase and Golgi α-mannosidase II. These enzymes are crucial for the catabolism of mannose-rich oligosaccharides and the processing of N-linked glycoproteins in cellular metabolism. By acting as a competitive inhibitor that binds to the active sites of these enzymes, swainsonine mimics the structure of mannose, thereby blocking the trimming of mannose residues from oligosaccharide chains during glycoprotein maturation and lysosomal degradation.^[9]^[25] This inhibition leads to the accumulation of hybrid mannose-rich oligosaccharides, such as Man₅GlcNAc₂, within lysosomes and the Golgi apparatus, resulting in a lysosomal storage disease characterized by cellular vacuolation and dysfunction across multiple tissues.^[26]^[27] The biochemical disruption caused by swainsonine extends to glycoprotein-dependent processes, impairing the synthesis and function of hormones, enzymes, receptors, and structural proteins essential for cellular integrity and signaling. In neurological tissues, this manifests as vacuolar degeneration in neurons, particularly in the central nervous system and retina, which compromises neurotransmitter processing and synaptic function due to altered glycan structures on neural glycoproteins. Reproductive effects arise from vacuolation in gonadal tissues, disrupting oogenesis and spermatogenesis by interfering with glycoprotein-mediated hormone signaling and gamete maturation; for instance, exposure leads to reduced fertility and embryonic development issues through malformed fetal membranes. Cardiac impacts are evident in myocardial cells, where vacuolation contributes to right ventricular hypertrophy and dilatation, especially exacerbated in cattle at high altitudes (above 3000 m), where swainsonine synergizes with hypoxic stress to induce congestive heart failure, known as high mountain disease or brisket disease.^[9]^[26]^[28] Toxicity develops primarily through chronic exposure, as acute high doses are limited by the unpalatability of locoweed, which deters excessive intake. In ruminants, lesions appear after ingestion of approximately 0.2 mg swainsonine/kg body weight/day over 21-45 days, with cumulative damage from low-level consumption (0.8-1.5 mg/kg/day in sheep and cattle) leading to progressive multi-organ vacuolation. Goats require higher doses (around 8 mg/kg/day) for symptoms within 9 days, while horses exhibit strong aversion to locoweed but remain vulnerable to chronic grazing, showing pronounced neurological effects at similar low doses. Ruminants such as cattle, sheep, and goats are most susceptible due to their ruminal fermentation aiding toxin absorption, whereas wildlife like deer display resistance, requiring prolonged high-dose exposure for significant impacts.^[9]^[29]^[28]

Health Effects

Pathology

Locoism, the toxic syndrome induced by chronic ingestion of swainsonine-containing locoweeds, manifests as a lysosomal storage disease characterized by the accumulation of mannose-rich oligosaccharides within lysosomes, leading to cellular vacuolation across multiple tissues. This vacuolation primarily affects neurons, macrophages in organs such as the liver, spleen, and lungs, hepatocytes, and renal tubular cells, resulting from the inhibition of lysosomal alpha-mannosidase enzymes. The buildup disrupts normal cellular function, causing progressive structural damage that is evident histopathologically after prolonged exposure.^[9]^[30] Neurological pathology is a hallmark of locoism, with degeneration concentrated in the brain, particularly the cerebellum and brainstem, where neuronal vacuolation and swelling lead to impaired coordination and potential ataxia. These changes arise from oligosaccharide accumulation in neuronal lysosomes, causing cytoplasmic enlargement and eventual cell death, which can become irreversible after extended toxin exposure exceeding several weeks. In livestock such as sheep and cattle, lesions in these brain regions appear after approximately 30 days of ingestion at doses around 1.8 mg swainsonine/kg body weight/day, contributing to persistent neurological deficits even if exposure ceases.^[9]^[30]^[31] Reproductive effects stem from the toxin's interference with gametogenesis and embryonic development, resulting in fetal resorption, abortion, and reduced fertility in affected livestock. In females, swainsonine disrupts ovarian function and prolongs estrous cycles, leading to embryonic lethality and autolysis in species like sheep and goats, with live birth rates dropping significantly. Males experience declined semen quality, including abnormal spermatozoa and inhibited spermatogenesis, further impairing breeding success in cattle and rams.^[25]^[9] Cardiac and pulmonary complications are prominent in cattle grazing locoweed at high altitudes above 8,000 feet, where the toxin exacerbates hypoxic conditions, inducing congestive heart failure through myocardial vacuolation and right ventricular hypertrophy. Microscopic examination reveals vacuolated cardiomyocytes and medial hypertrophy in pulmonary arteries, increasing vascular resistance and leading to pulmonary hypertension. This altitude-specific pathology results in gross lesions such as ventricular dilatation and edema, observed in calves fed locoweed at elevations of 2,100-3,000 meters.^[32]^[9] Emaciation occurs despite adequate feed intake, driven by malabsorption in vacuolated gastrointestinal and hepatic cells, coupled with heightened metabolic demands from dysfunctional, oligosaccharide-laden tissues. This leads to inefficient nutrient utilization and progressive weight loss in livestock, with economic losses estimated at $75-282 per affected stocker cattle head. The incubation period for pathological changes typically spans 2-4 weeks of chronic ingestion before tissue-level damage becomes evident, with clinical recovery possible within 2 weeks of removal from exposure if initiated early; however, neurological lesions often persist, preventing full reversal.^[9]^[30]

Clinical Signs in Livestock

Locoweed poisoning, known as locoism, manifests in livestock through a range of observable behavioral and physiological symptoms primarily resulting from chronic ingestion of the plant's toxin swainsonine.^[1] Affected animals initially show subtle changes that progress to severe debilitation, with signs appearing after 2-3 weeks of continuous exposure.^[33] Neurological signs are hallmark features of locoism across species, including ataxia characterized by staggering, irregular gait, and loss of muscular control; aimless wandering; depression and lethargy; head pressing; circling; hyperexcitability or extreme nervousness when stressed; and occasional convulsions.^[2]^[34] In horses, these may include overreaction to stimuli, such as head shyness or rearing, alongside incoordination and exaggerated high-stepping gait.^[34] Cattle and sheep exhibit similar symptoms, often with excessive salivation, apparent blindness, and tremors visible during movement.^[2]^[33] Emaciation and weakness develop as prominent physiological changes, leading to a starved appearance despite an initially normal appetite; animals become reluctant to move, exhibit progressive weight loss, and show increased susceptibility to predators due to diminished mobility and unthriftiness.^[1]^[35] Dull hair coats and glassy eyes in cattle further highlight this wasting state.^[9] Reproductive issues are common, encompassing abortion, stillbirths, infertility, and birth defects such as skeletal malformations in offspring; males experience libido loss and cessation of spermatogenesis, while females show delayed estrus, lengthened cycles, and reduced placental development.^[1]^[33] Offspring from affected pregnancies are often small, weak, and prone to high neonatal mortality.^[33] Species-specific variations include pronounced weight loss and occasional convulsions in sheep and goats, alongside general locoism; horses develop a conditioned aversion to the plant but still suffer abortions and permanent neurological deficits with poor prognosis; cattle may exhibit additional signs like water belly (hydrops), high-altitude heart failure with labored respiration and jugular pulse, and severe emaciation leading to death from starvation or secondary infections.^[1]^[2]^[34] The condition progresses from an acute phase within 1-2 weeks, featuring mild incoordination and subtle tremors, to a chronic phase over months, resulting in severe debilitation, persistent neurological damage, and eventual death if exposure continues.^[33]^[34] Recovery is possible within weeks if animals are removed from infested areas, though some neurological signs may recur unpredictably.^[1] In wildlife, similar signs appear in mule deer, elk, and antelope, including emaciation, ataxia, and behavioral changes that can mimic chronic wasting disease, potentially leading to misdiagnosis in locoweed-heavy areas.^[1]^[36]

Diagnosis and Treatment

Diagnostic Methods

Diagnosis of locoweed poisoning, or locoism, begins with a thorough history of animal exposure, particularly assessing whether livestock have grazed in areas known to harbor locoweed species such as Astragalus or Oxytropis during peak toxicity periods in spring (March to May) or fall when green growth is prominent and alternative forages are limited.^[9]^[4] Veterinary evaluation includes clinical neurologic examination for signs like ataxia, supplemented by laboratory confirmation through detection of swainsonine in serum using methods such as high-performance liquid chromatography (HPLC) or other chromatographic methods, where detectable levels confirm exposure and intoxication.^[37]^[38] Biochemical tests further support diagnosis by measuring reduced serum alpha-mannosidase activity, often below 20% of normal levels due to swainsonine's inhibitory effect on this lysosomal enzyme, and analyzing urine for elevated mannose-rich oligosaccharides characteristic of the resulting storage disorder.^[39] In cases of suspected fatal poisoning, post-mortem examination reveals histologic vacuolation in neuronal and epithelial cells of the brain, liver, and kidneys, along with identifiable locoweed plant residues in the rumen content. Histopathology is often considered the most reliable confirmatory method, revealing characteristic vacuolar degeneration in affected tissues.^[40]^[2]^[41] Differential diagnosis is essential to distinguish locoism from conditions presenting similar neurologic deficits, such as chronic selenium toxicity (which may involve hair loss and elevated serum selenium levels), polioencephalomalacia due to thiamine deficiency (confirmed by brain histopathology showing cortical necrosis), or chronic wasting disease (CWD) in cervids (ruled out via polymerase chain reaction [PCR] testing for prions in brain or lymphoid tissues).^[4]^[42]

Treatment Approaches

Treatment for locoweed poisoning, known as locoism, primarily involves immediate removal of affected livestock from contaminated pastures to halt further toxin exposure, as no specific antidote exists to reverse the effects of swainsonine, the primary alkaloid responsible.^[2]^[1] Early intervention, ideally within the first few weeks of symptom onset, can facilitate partial recovery by allowing the body to resume normal glycoprotein processing, though lysosomal storage lesions in neurons and other tissues often persist.^[34] Supportive care focuses on nutritional supplementation with high-quality, energy-dense feeds to address emaciation and weight loss common in poisoned animals, alongside intravenous fluids if dehydration is present.^[2] Symptom management is symptomatic and supportive, with anti-inflammatory drugs sometimes used to reduce neurologic swelling and discomfort, particularly in horses exhibiting ataxia or depression.^[43] Veterinary monitoring is essential to detect and treat secondary infections, such as pneumonia or abortions, with antibiotics administered as needed; however, these measures do not address the underlying lysosomal dysfunction.^[33] For reproductive complications like infertility, hormone therapies have been explored but show limited success, often leading to economic decisions to cull severely affected animals due to persistent breeding issues.^[34] Experimental approaches, including potential mannose-based supplements to compete with swainsonine or enzyme replacement therapies, remain unproven and inconclusive based on pre-2025 research trials, with no widely adopted antidotes identified.^[9] Prognosis varies by exposure duration and severity: mild cases with prompt removal may achieve partial neurologic and physical recovery, while chronic intoxication frequently results in irreversible damage, rendering animals unsafe or unproductive.^[2]^[4] In horses, locoism is often considered permanent, with behavioral alterations persisting despite intervention.^[34]

Prevention and Management

Strategies for Avoidance

Effective strategies for avoiding locoweed poisoning in livestock emphasize proactive grazing practices to minimize exposure during periods of high palatability. Grazing management techniques include delaying livestock turnout until mid-summer, when locoweed becomes less palatable due to its seasonal growth cycle, and providing supplemental feed to reduce selective grazing on the plant.^[44] These approaches ensure adequate nutritious forage availability, preventing animals from seeking out locoweed when other vegetation is scarce.^[9] Reducing stocking rates in infested areas further decreases grazing pressure, allowing desirable plants to thrive and outcompete locoweed.^[45] Range rotation systems, such as rest-rotation grazing, promote uniform forage utilization and help avoid overgrazed patches where locoweed dominates.^[9] By periodically resting pastures, these methods maintain plant diversity and limit livestock access to concentrated locoweed stands. Herding practices can also steer animals away from known infestations, enhancing overall distribution across rangelands.^[46] Chemical controls target young locoweed plants in spring for optimal efficacy, with herbicides like picloram or 2,4-D applied foliarly achieving up to 85% control when combined.^[47] These treatments are most effective on vegetative to early-bloom stages, reducing plant density for several years.^[48] Biological approaches, such as targeted pre-bloom grazing by sheep, are under evaluation to suppress locoweed without broad environmental impacts, showing potential in short-term vegetation studies. Aversion training conditions livestock to avoid locoweed using lithium chloride as an emetic agent, administered after controlled plant consumption. In horses, this method has demonstrated success in approximately 83% of cases, with treated animals consuming significantly less locoweed in subsequent tests compared to controls.^[50] Such conditioning can persist, reducing voluntary ingestion in field settings.^[9] Monitoring locoweed populations through GIS mapping allows ranchers to identify and track infested stands, informing targeted avoidance and control efforts.^[51] Seasonal risk education for producers highlights peak vulnerability periods, integrating observations with management plans to preempt exposure.^[10] Integrated pest management combines these tactics with soil enhancements, such as fertilization and reseeding competitive grasses, to favor desirable vegetation over locoweed in the long term.^[9] This holistic approach minimizes reliance on any single method while sustaining rangeland health.^[46]

Economic Impact

Locoweed poisoning imposes significant direct economic losses on ranchers, primarily through reduced profitability and impacts on livestock productivity. Affected operations in the western United States experience profit reductions of 30-40%, driven largely by reproductive failures such as abortions and infertility that can affect up to 20% of the herd.^[52]^[9] These issues necessitate higher replacement rates for heifers and contribute to overall herd inefficiency. Additionally, mortality rates in severe outbreaks range from 2-3% on average, with higher incidences like 5-10% possible in heavily infested areas, leading to culling and lost production. Weaned calves from poisoned dams are often lighter by 66 pounds, reducing sale values by approximately $50-100 per head based on market weights.^[9]^[9]^[52] Historical data underscores the scale of these losses, with U.S. ranchers reporting $8 million in annual damages from locoweed in 2004, affecting 4% of cow-calf operations and 25% of stocker operations, particularly in states like New Mexico and Arizona.^[53] These impacts persist in western rangelands, where locoweed contributes to broader poisonous plant losses exceeding $250 million yearly across the livestock sector.^[54] Locoweed remains a persistent threat, with estimates of $100 million in annual U.S. losses as of 2009 (Cook et al., 2009).^[55] Control measures add further costs, including herbicide applications and aversion training programs. Lost grazing productivity compounds these expenses, as infested pastures require delayed or reduced stocking rates.^[33] Broader economic effects include elevated veterinary costs for diagnosis and treatment, as well as increased demand for replacement animals due to fertility impairments in both males and females. Wildlife populations, such as deer and elk, also suffer from locoweed toxicity, potentially reducing hunting success and associated revenues in affected regions.^[9]^[33] Improved management practices, including integrated control and monitoring, have helped reduce losses in monitored rangelands. Climate change may exacerbate impacts by expanding locoweed habitats northward and to higher elevations, with ongoing USDA research focusing on adaptive strategies as of 2025.^[55]^[56]

References

[1]
Locoweed (Astragalus and Oxytropis spp.) - USDA ARS
Jun 26, 2018 · Locoweed is found on foothills and semiarid regions. It grows in tufts or clumps, 4 - 24 inches high. Locoweed gets its name from the Spanish word loco (crazy).Missing: scientific | Show results with:scientific
[2]
Locoweed - Guide to Poisonous Plants
Description Perennial herbaceous plants with long tap root. Leaves are grouped basally, 8-12 inches long, odd-pinnate compound and covered with silvery hairs.Missing: scientific | Show results with:scientific
[3]
Locoweed | USU
Scientific Name: Astragalus L. Scientific Name Synonyms: ASTRA. Symbol ... Signs of poisoning appear after 2 to 3 weeks of continuous grazing on the plant.
[4]
[PDF] Locoweed Poisoning in Livestock - University of Arizona Journal
Locoism was first recognized in horses by De Soto and other Spanish explorers in the Southwestern United States. In the 1800s as settlers and stockmen moved ...Missing: history etymology 1873 origin<|control11|><|separator|>
[5]
A swainsonine survey of North American Astragalus and Oxytropis ...
Locoism was first noted by De Soto and other Spanish explorers in the Southwestern United States in their horses. As the American frontier was settled ...
[6]
[PDF] Locoweed on High Mountain Range - University of Arizona Journal
The first pub- lished account of locoweed poisoning appeared in the Year. Book of Agriculture in 1873. In 1906 Marsh (1909) conclu- sively demonstrated that ...
[7]
indolizidine alkaloids of spotted locoweed (Astragalus lentiginosus)
Loco intoxication: indolizidine alkaloids of spotted locoweed (Astragalus lentiginosus). Science. 1982 Apr 9;216(4542):190-1. doi: 10.1126/science.6801763.Missing: discovery 1979
[8]
(PDF) Intoxicación por Astragalus pehuenches (locoismo) en ovinos ...
Aug 6, 2025 · Two hundred and twenty (73%) out of 300 sheep died during the outbreak which lasted for more than two months. The clinical course ranged from 8 ...
[9]
[PDF] Locoweed Toxicity, Ecology, Control, and Management - USDA ARS
Some species of Astragalus and Oxytropis contain the indolizidine alkaloid swainsonine that causes the poisoning syndrome known as locoism. Swainsonine is ...Missing: 1873 | Show results with:1873
[10]
A Guide to the Common Locoweeds and Milkvetches of New Mexico
Plants growing in conspicuous clumps and with a distinct pungent smell of selenium, hairs basifixed, flowers bluish to whitish, pods strongly two-grooved.
[11]
A survey of swainsonine content in Swainsona species
Swainsonine was detected in 9 of the 41 Swainsona species, eight of which had not been determined to contain swainsonine previously using modern instrumentation ...
[12]
Phylogenetic Patterns of Swainsonine Presence in Morning Glories
The indolizidine alkaloid swainsonine is produced by heritable fungi that occurs in diverse plant families, such as locoweeds (Fabaceae) and morning glories ( ...
[13]
Production of the Alkaloid Swainsonine by a Fungal Endophyte in ...
Plants belonging to the genera Astragalus, Oxytropis, Ipomoea, Sida, and Swainsona often contain the toxin swainsonine (SW), which causes a neurological ...
[14]
Production of swainsonine by fungal endophytes of locoweed
Endophyte-infected locoweed populations produced swainsonine, and the swainsonine level of endophyte strains in vitro was highly correlated with the swainsonine ...Missing: Rhizoctonia | Show results with:Rhizoctonia
[15]
Swainsonine-producing fungal endophytes from major locoweed ...
The presence of swainsonine in locoweeds was also reported to be probable as the result that the plant is contaminated with Rhizoctonia leguminicola or a ...
[16]
white locoweed toxicity is facilitated by a fungal endophyte and ...
Livestock poisoning is attributed to the alkaloid swainsonine, which is synthesized inside the plant by the fungal endophyte Embellisia sp. In this study, the ...Missing: Rhizoctonia | Show results with:Rhizoctonia
[17]
[PDF] Locoweed Population Cycles - USDA ARS
3) Long-lived perennial plants grow where moisture is more abundant and more regularly available. The plants flower and produce seed for many years following ...
[18]
Oxytropis sericea - Forest Service - USDA
White locoweed fixes atmospheric nitrogen. It has potential to add significant amounts of nitrogen to forest sites in the Inland Northwest because of its ...
[19]
Poisonous Plants on Rangelands: Locoweed and Crazyweed
Oct 24, 2022 · Locoweeds get their name from the Spanish word “loco,” which means crazy. Both locoweeds and crazyweeds cause a condition called locoism or loco ...
[20]
Oxytropis DC. | Plants of the World Online | Kew Science
Native to: Afghanistan, Alaska, Albania, Alberta, Altay, Amur, Arizona, Austria, Baltic States, Belarus, British Columbia, Bulgaria, Buryatiya, California, ...<|separator|>
[21]
Predicted Distribution of Locoweed Oxytropis glabra in China under ...
May 29, 2024 · Oxytropis glabra DC, a member of the Fabaceae family, is native to China and various regions in Asia and Europe, such as Mongolia, Pakistan, and ...
[22]
Production of the alkaloid swainsonine by a fungal endosymbiont of ...
Apr 24, 2013 · These convolvulaceous species including Ipomoea carnea contain the indolizidine alkaloid swainsonine, an inhibitor of α-mannosidase and ...
[23]
Poisonous Plant Research: Logan, UT - Publication : USDA ARS
Apr 2, 2013 · These convolvulaceous species including Ipomoea carnea contain the the glycosidase inhibitors swainsonine and the calystegines. Swainsonine has ...
[24]
Reproductive Toxicities Caused by Swainsonine from Locoweed in ...
Swainsonine is the primary toxin in locoweeds. It causes intention tremors, reproductive dysfunction, emaciation, and death. The objective of the present ...
[25]
Pathogenesis and preventive treatment for animal disease due to ...
[55], ingestion of locoweeds by cattle, sheep and horses can cause the neurological condition called locoism. Apart from that, the swainsonine toxicity may also ...
[26]
The Toxicology Mechanism of Endophytic Fungus and Swainsonine ...
The toxic component in locoweed has been identified as swainsonine, an indolizidine alkaloid. Swainsonine inhibits lysosomal a-mannosidase and mannosidase II, ...
[27]
Swainsonine-induced High Mountain Disease in Calves - PubMed
Swainsonine, an indolizidine alkaloid in the locoweeds (certain species of the Astragalus and Oxytropis genera), was fed to young Holstein bull calves in ...Missing: cardiac | Show results with:cardiac
[28]
Metabolomic analysis of swainsonine poisoning in renal tubular ...
May 20, 2024 · Swainsonine (SW) is an indolizidine alkaloid, which is the main toxic component of locoweed (9–11). SW-induced toxicity is primarily ...
[29]
The Lesions of Locoweed (Astragalus mollissimus), Swainsonine ...
To better characterize and compare the toxicity of and lesions produced by locoweed (Astragalus mollissimus) with those of swainsonine and a related ...
[30]
Swainsonine as a lysosomal toxin affects dopaminergic neurons
When chronically ingested by livestock and wildlife, symptoms include severe neuronal disturbance. Toxicity to the central and peripheral nervous system is ...
[31]
Locoweed (Oxytropis sericea) poisoning and congestive heart ...
SUMMARY. Locoweed (Oxytropis sericea),when fed to calves at high elevations, increased the prevalence and sever ity of congestive heart failure.Missing: swainsonine | Show results with:swainsonine
[32]
A Guide to Locoweed: Poisoning and Management
Botanical Description. Densely leafy plants growing typically in the Santa Catalina mountains; plants perennial; stems a foot long or longer, very numerous ...
[33]
Locoweed Poisoning of Horses | New Mexico State University
Locoweed has been reported to be the most widespread poisonous plant problem in the Western United States. It has a substantial economic impact and may be ...
[34]
Range Plants of Temperate North America - Toxicology
death · chronic illness and debilitation · decreased weight gain · abortion · birth defects · increased parturition interval · photosensitization.
[35]
Locoweed (Oxytropis sericea)-induced lesions in mule deer ...
The purpose of this study was to induce and describe chronic locoweed poisoning in deer and compare it with the lesions of CWD.
[36]
Effects of locoweed on serum swainsonine and selected ... - PubMed
A study was conducted to evaluate the effects of acute and subacute locoweed exposure on serum swainsonine concentrations and selected serum constituents in ...Missing: ELISA | Show results with:ELISA
[37]
LOCOWEED MANAGEMENT: INTEGRATED MANAGEMENT ...
Using an HPLC system coupled to a Refractive Index detector and a Radioisotope detector to successfully separated and detected the precursor of swainsonine, 14C ...
[38]
Alpha-Mannosidase-II Deficiency Results in Dyserythropoiesis and ...
Ingestion by vertebrates produces a disease known as “locoism,” biochemically similar to α-mannosidosis and associated with aberrant behavior, male sterility, ...
[39]
The Pathogenesis and Toxicokinetics of Locoweed (Astragalus and ...
The purpose of this review is to present recent research on swainsonine toxicokinetics and locoweed-induced clinical and histologic lesions. Swainsonine ...Missing: discovery 1979 1982<|control11|><|separator|>
[40]
[PDF] Neuropathology and diagnostics in food animals - CORE
Diagnosis of polioencephalomalacia requires examination of the brain and elimination of the other two conditions. Selenium toxicity in pigs can cause necrosis ...
[41]
[PDF] Neurotoxic Plants that Poison Livestock - ScienceDirect.com
Chemical detection of serum and tissue swainsonine concentrations can also be used to identify animals currently ingesting locoweeds. However, these assays have ...
[42]
Locoism in Horses: Signs, Treatment & Prevention - HorseDVM
Therapies ; Remove horses from the locoweed source, This may alleviate some of the associated clinical signs, however in most cases the behavioral changes are ...<|separator|>
[43]
Locoweed grazing - PubMed
Many locoweeds are the first plants to begin growth in the spring and regrow in the fall. Livestock generally prefer the green-growing locoweeds to other ...
[44]
[PDF] Integrated Toxic Plant Management Handbook - Val Verde County
In areas infested with toxic plants, decrease grazing pressure by reducing the number of animals per area of land. This allows the animals to selectively graze ...
[45]
Locoweed Poisoning in Livestock - BioOne Complete
Feb 1, 2009 · 1. Restrict Access · 2. Do Not Overstock Locoweed-Infested Areas · 3. Sort Out Animals That Graze Locoweeds · 4. Herbicide Controls · 5. Train ...
[46]
Herbicidal control of locoweed. | Request PDF - ResearchGate
Control of White Locoweed (Oxytropis sericea) with Aminopyralid + 2 ... herbicide application ... picloram + 2,4-D: 85%; control: 76%). View. Show ...
[47]
Herbicide Control of Locoweeds: A Review | Weed Technology
Jun 12, 2017 · This paper presents a historical review of control methods to reduce locoweed plant density. Hand grubbing, the most common method of control ...
[48]
Targeted Grazing of White Locoweed: Short-Term Effects of ...
Mar 8, 2021 · Targeted Grazing of White Locoweed: Short-Term Effects of Herbivory Regime on Vegetation and Sheep ; dc.publisher, Society for Range Management.<|control11|><|separator|>
[49]
Conditioning taste aversions to locoweed (Oxytropis sericea) in horses
Pen tests indicated that most horses (5/6) were completely averted from locoweed. Treated horses ate 34 g of fresh locoweed compared to 135 g for controls (P < ...Missing: training success rate
[50]
Ranch Mapping & GIS - Paladin Ranch Resources
GIS provides a visual framework for conceptualizing and understanding your ranch. An updated GIS database will greatly improve the efficiency of all other ...Missing: stands | Show results with:stands<|control11|><|separator|>
[51]
"Locoweed Poisoning in Cattle: An Overview of the Economic ...
Ranchers interviewed in this study estimated their losses due to locoweed poisoning to be from 30 to 40 percent reduction in profit. Although profit margins ...
[52]
Locoweed Poisoning in New Mexico and Western US Solutions
Locoweeds contain the toxic alkaloid swainsonine. Swainsonine concentrations differ between locoweed species. Levels of swainsonine are generally greater in ...Missing: seasonal | Show results with:seasonal
[53]
[PDF] Plants Poisonous to Livestock in the Western States - USDA ARS
Poisonous plants are a major cause of economic loss to the livestock industry. Each year these plants ad- versely affect 3 to 5 percent of the cattle, sheep, ...
[54]
[PDF] Poisonous Plants on Rangelands - Cooperative Extension
Locoweed poisoning alone is estimated to cause $100 million in losses annually (Cook et al., 2009). The economic impact of poisonous plants of livestock can ...