Fact-checked by Grok 2 weeks ago

Offspring

In , offspring are the progeny or young produced by living through , serving as the means for continuation and genetic transmission across generations. Offspring result from either , involving genetic contributions from two parents to create genetically diverse individuals, or , where a single parent produces genetically identical clones. This process ensures inheritance of traits, enabling and , and encompasses a wide range of forms across animals, , and other .

Etymology and Definition

Etymology

The term "offspring" originates from ofspring, denoting "children or young collectively, descendants," literally referring to "those who spring off (someone)," formed from of meaning "away, away from" and springan "to spring." This first appears around , emphasizing the idea of emergence or derivation from a source. Through , the word evolved as ofspring or oxspring, retaining its core sense of progeny while entering broader usage by the late . In , it encompasses biological descendants and has developed synonyms such as progeny—from Latin progenies "descendants," via progenie, meaning "kin or offspring" since the early , from issue "a way out," extended to "children" by the late in legal contexts denoting lineal descendants, and scion, from cion "descendant or shoot," used figuratively for heirs since around 1300. Comparatively, in Latin, proles signifies "offspring or progeny," derived from prolēre "to produce new life," combining pro- "forth" and a base related to nourishment or growth, as seen in classical texts for descendants or generation. In , genos (γένος) conveys "race, family, or offspring," from the root of gignomai "to be born," denoting , , or progeny in contexts like or kind. By the , "" began shifting from strictly literal biological descent to metaphorical applications in , denoting products or results, such as intellectual or creative yields, with the figurative sense "that which is produced by something" firmly established by around 1600.

Definition

In , offspring refers to the immediate product of in living organisms, consisting of the young individuals produced through either sexual or processes. This encompasses new organisms that inherit genetic material from one or more parents, ensuring the continuation of . The term distinguishes between contexts: biologically, offspring are genetic descendants carrying parental traits; legally, they denote heirs or issue in inheritance matters; and metaphorically, they represent creations, products, or followers arising from an original source. Key related terms include the F1 generation in , which describes the first filial generation of hybrid offspring from a cross between two distinct parents; brood, referring to a group of young animals, particularly or , hatched or born simultaneously; and progeny, a formal for descendants or collective offspring in scientific and legal discourse. The concept applies broadly to all forms of life, from multicellular animals and to unicellular microbes such as , where offspring arise via processes like , but it excludes replication in non-living entities like viruses or machines. The word derives from ofspring, literally meaning "those who spring off" from a .

Biological Reproduction

Sexual Reproduction

Sexual reproduction is a in which two parent organisms contribute genetic material to produce , typically through the fusion of specialized haploid gametes—a cell from one parent and an from the other—resulting in a diploid that develops into a new individual. This fusion restores the diploid chromosome number, combining half the genetic material from each parent to create genetically unique . A key mechanism driving in occurs during , the cell division process that produces haploid s. In I of , homologous chromosomes pair and undergo crossing over, where segments of DNA are exchanged between nonsister chromatids, shuffling alleles and generating recombinant chromosomes that differ from those in the parents. This recombination, along with the independent assortment of chromosomes during I, ensures that each gamete carries a unique combination of genetic traits, promoting diversity among offspring. In animals, sexual reproduction commonly involves internal or external fertilization, where and unite to form a ; for instance, in mammals, fertilization occurs in the female reproductive tract, leading to embryonic development. In , particularly angiosperms, the process begins with , the transfer of grains containing male gametes to the of the female flower, followed by in the : one fuses with the to form the , while the second fuses with polar nuclei to form the triploid , which nourishes the developing . This double event is unique to flowering and ensures coordinated development of the and its nutrient supply. The primary advantage of sexual reproduction lies in the genetic diversity it generates, which enhances a species' adaptability to environmental changes, such as evolving pathogens or shifting climates, by providing a broader pool of traits for to act upon. For example, this variation can improve resistance to diseases through novel combinations. Additionally, sex determination in many , including humans and other mammals, is governed by : females typically have two X chromosomes (XX), while males have one X and one Y (XY), with the Y chromosome's Sry triggering male development during embryogenesis. This chromosomal contributes to the binary observed in many , further diversifying reproductive strategies.

Asexual Reproduction

Asexual reproduction involves the production of offspring from a , resulting in genetically identical progeny known as clones. This process occurs without the fusion of gametes or , allowing for efficient propagation in various taxa from prokaryotes to eukaryotes. Common mechanisms include binary fission, , fragmentation, and , each adapted to the of specific organisms. In binary fission, prevalent among and , the parent cell duplicates its single circular and divides symmetrically into two daughter cells that are exact genetic copies. , a mechanism employed by unicellular fungi such as (), involves the formation of a protuberance on the parent cell that grows, receives a copy of the , and eventually separates as a smaller but genetically identical offspring. Fragmentation is observed in certain like ( spp.), where the body can break into segments due to injury or environmental stress, with each viable fragment regenerating the missing parts to form a complete, clonal individual. , found in some reptiles including whiptail lizards (Aspidoscelis spp.) and mourning geckos (), entails the development of an unfertilized egg—either haploid or diploid—into a fully formed without male contribution. The clonal nature of asexual offspring means they possess the same as the , leading to uniform phenotypic traits and no introduction of novel genetic combinations. This lack of recombination preserves advantageous adaptations but heightens population vulnerability to environmental perturbations, such as pathogens or climatic shifts, since a deleterious mutation or stressor can impact the entire group uniformly. For instance, ( family) utilize to produce live female young rapidly, enabling exponential population surges in stable, resource-rich habitats without the energy costs of mate-searching. Similarly, bacterial binary fission supports short replication cycles, often 20-30 minutes in species like under ideal conditions, facilitating swift adaptation through mutation accumulation rather than recombination. Evolutionarily, asexual reproduction excels in promoting rapid population expansion in predictable environments, where maintaining proven genotypes outweighs the benefits of from sexual processes. This strategy supports quick colonization of niches and high reproductive output, though it contrasts with sexual reproduction's role in generating variability to buffer against changing conditions.

Offspring in Animals

Vertebrates

Vertebrates exhibit a diverse array of reproductive modes for producing offspring, primarily categorized into oviparity, ovoviviparity, and viviparity. In oviparity, common among birds, most reptiles, and many fish, females lay eggs that develop externally, with the embryo nourished by yolk reserves until hatching. Ovoviviparity occurs in certain fish, such as some sharks and reptiles like vipers, where eggs develop internally within the mother's body, hatching just before or after birth without direct nutrient transfer from the parent. Viviparity, prevalent in mammals and some reptiles and fish, involves live birth where the embryo develops inside the mother, often supported by a placenta that facilitates nutrient and gas exchange. Embryonic development in amniotes—encompassing reptiles, birds, and mammals—relies on specialized extraembryonic membranes that protect and sustain the offspring. The provides initial nourishment from the egg yolk, absorbing nutrients for the in oviparous species, while in viviparous forms it may contribute to early vascular connections before development. The , formed from maternal and fetal tissues, becomes the primary interface in viviparous vertebrates, enabling prolonged internal and higher offspring survival rates compared to external development. These structures allow amniotes to reproduce in terrestrial environments by preventing and supporting complex . Parental care in vertebrates varies widely, enhancing offspring survival through protection, feeding, and . Marsupials, such as , exemplify specialized care where underdeveloped young crawl into a maternal pouch upon birth, and developing further in a secure for months. In , offspring are classified as altricial, like songbirds that hatch helpless and require intensive feeding, or precocial, such as that are mobile and forage soon after hatching but still receive guidance. This spectrum reflects trade-offs in energy investment, with altricial young allowing for more offspring but demanding prolonged care. Offspring adaptations in vertebrates focus on survival strategies tailored to environmental pressures. In fish, newly hatched fry often form schools to confuse predators, diluting individual risk and improving foraging efficiency in open waters. Such behaviors, combined with modes like viviparity in sharks, increase post-hatching viability by shielding vulnerable young during critical early stages.

Invertebrates

Invertebrates exhibit a remarkable diversity in offspring production strategies, adapted to their varied habitats and life histories, ranging from broadcast spawning in aquatic environments to complex in terrestrial . Unlike vertebrates, many rely on high-volume to compensate for high mortality rates in early stages, often producing vast numbers of with minimal individual investment. This approach contrasts with the more resource-intensive care seen in some social groups, highlighting the evolutionary trade-offs in invertebrate reproduction. Sexual reproduction in invertebrates includes both external and internal fertilization. External fertilization is prevalent among marine species, such as sea urchins (Strongylocentrotus purpuratus), where females release large numbers of eggs into the water column, and males simultaneously broadcast sperm for random encounters, ensuring species-specific gamete interactions through molecular recognition mechanisms like bindin proteins on sperm. In contrast, internal fertilization dominates in terrestrial and some aquatic insects, where sperm is transferred directly to the female's reproductive tract during mating, allowing controlled fertilization as eggs pass through the oviducts; this method enhances offspring survival by protecting gametes from environmental hazards. Many insects, including butterflies (Lepidoptera), undergo complete metamorphosis, with offspring progressing through distinct larval stages—such as the caterpillar, which feeds voraciously—before pupation and emergence as winged adults, enabling ecological specialization across life phases. Brood sizes vary widely, reflecting reproductive strategies tied to offspring vulnerability. Marine invertebrates with planktonic larvae, like sea urchins, demonstrate high , with females producing 100,000 to 2,000,000 eggs per spawning event to overcome predation and dispersal losses in open water. In social insects such as (Formicidae), queens produce fewer offspring per clutch—typically hundreds rather than millions—supported by worker castes that provide collective care, allowing for higher per-offspring investment and colony-level success despite lower individual . Protective mechanisms further diversify invertebrate parental strategies. Spiders (Araneae) encase their eggs in egg sacs, which shield developing embryos from , predators, and pathogens; these sacs, often flask-shaped and containing up to 250 eggs, may be guarded or hidden in webs. Octopuses (Octopoda), particularly deep-sea species like Graneledone boreopacifica, employ brooding, where females continuously ventilate and clean egg clusters in dens, defending them from threats for extended periods—up to 4.5 years in some cases—often at the cost of forgoing food. Environmental cues strongly influence timing and success of offspring production. Corals (), for instance, synchronize mass spawning events seasonally during warmer months, triggered by lunar cycles; spawning typically occurs 3–5 nights after the , with gametes released en masse in a brief window to maximize fertilization rates under and conditions. Some also employ , such as fragmentation in like planarians, where body fragments regenerate into complete individuals, supplementing sexual output in stable environments.

Offspring in Plants

Angiosperms

Angiosperms, commonly known as flowering plants, generate offspring via seeds that develop within protective fruits, a process that integrates pollination, fertilization, and dispersal to ensure reproductive success. This seed-based reproduction distinguishes angiosperms from other plants and supports their dominance in diverse ecosystems. Pollination in angiosperms relies on biotic and abiotic vectors to transfer pollen from the anthers of one flower to the stigma of another. Insect vectors, such as bees and butterflies, are attracted to colorful, scented flowers, while wind serves as a vector for inconspicuous, petal-less flowers that produce abundant lightweight pollen. Birds and bats pollinate tubular or musky-scented flowers, respectively. Self-pollination, where pollen transfers within the same flower or plant, can occur in perfect flowers containing both stamens and carpels, but many species employ barriers to favor cross-pollination from genetically distinct plants, which fosters hybrid vigor and increased offspring adaptability. Upon successful , a grows from the grain through the to deliver two cells to the ovule's embryo sac, initiating —a defining feature of angiosperm . One fuses with the haploid to form a diploid , which divides to develop into the , the future offspring plant. Simultaneously, the second unites with the two polar nuclei in the central to produce a triploid , a nutrient-rich that sustains the during development and early growth. This dual fertilization event ensures efficient resource allocation for the offspring. Mature seeds, enclosed in fruits derived from the , facilitate dispersal to new locations, minimizing with the parent. Wind dispersal is common in lightweight seeds equipped with plumes or wings, as seen in dandelions, where parachute-like pappus structures allow airborne transport. Animal-mediated dispersal involves fleshy fruits like berries, which are ingested, with viable seeds later deposited in feces far from the source. Water dispersal occurs in buoyant fruits such as coconuts, enabling long-distance oceanic travel. These mechanisms enhance survival by promoting spatial separation. Seed marks the transition from to active , triggered by suitable environmental cues like and temperature. The process commences with , where the dry absorbs water, often equivalent to 30–50% of its dry weight or more, activating enzymes that break down stored reserves in the and cotyledons into usable sugars and . This swelling ruptures the seed coat, allowing the , or embryonic , to emerge and anchor the while absorbing water and minerals. Next, the elongates via the epicotyl, pushing through the ; in (e.g., beans), cotyledons rise above ground to photosynthesize briefly, whereas in hypogeal types (e.g., peas), they remain below. Establishment concludes as true leaves expand, roots branch, and the achieves photosynthetic independence, utilizing cotyledon nutrients until then.

Gymnosperms and Non-Vascular Plants

Gymnosperms, a group of seed-producing plants that includes such as pines, reproduce through the formation of naked seeds exposed on the scales of cones rather than being enclosed within fruits. These seeds develop from on female cones, where megaspores are produced via in megasporangia and develop into female gametophytes that contain egg cells. , formed in on male cones, mature into pollen grains that serve as the male gametophytes, containing sperm cells. occurs primarily through wind dispersal, with pollen grains carried by air currents to the female cones, where a pollination drop captures them near the . Fertilization follows, often delayed for months or years, leading to development within the seed coat, which provides protection without an enclosing . In non-vascular plants, such as mosses (bryophytes), reproduction relies on spores rather than seeds, with a life cycle dominated by the haploid gametophyte generation that produces gametes through mitosis. The diploid sporophyte generation is dependent on the gametophyte and develops from the fertilized egg, producing haploid spores via meiosis in a capsule atop a seta. This alternation of generations features a prominent, photosynthetic gametophyte that forms the main plant body, while the sporophyte is short-lived and nutritionally reliant on it. Ferns, though vascular and seedless, share spore-based reproduction with a similar alternation but exhibit a dominant sporophyte generation, with the small, independent gametophyte (prothallus) producing gametes in archegonia and antheridia. Seed dispersal in gymnosperms like often involves winged structures attached to the seeds, enabling and extended flight on currents to promote wider distribution away from the parent . In contrast, non-vascular such as bryophytes release spores in massive quantities as lightweight clouds carried by , facilitating long-distance dispersal despite the ' small size and lack of . These reproductive strategies confer adaptations for resilience in harsh environments; seeds maintain and protect embryos from , allowing survival in dry or cold conditions for extended periods. spores exhibit high , remaining viable after for years or even decades before germinating upon rehydration, enabling colonization of exposed, water-limited habitats. Asexual vegetative propagation, such as gemma production in mosses, supplements by enabling rapid local spread without spores or seeds.

Human Offspring

Biological Development

Human biological development begins with fertilization, the union of a and during , forming a that contains the complete set of genetic material. The prenatal period encompasses three main stages: germinal, embryonic, and fetal. The germinal stage lasts from fertilization to implantation in the uterine wall, approximately one week, during which the divides rapidly into a . The embryonic stage spans weeks 1 through 8 post-fertilization, marked by —the formation of major organs and structures such as the , heart, and limbs—making this period highly sensitive to teratogens that can lead to congenital anomalies. By the end of week 8, the measures about 3 cm and has distinct human features. The fetal stage, from week 9 until birth, involves rapid growth and maturation of , with the fetus becoming viable outside the womb around 24 weeks, though survival rates improve significantly after 28 weeks due to and development. Key milestones include the formation of viable systems by the second and fat accumulation for in the third . The average period is 40 weeks from the last menstrual period, or 38 weeks post-fertilization. Birth occurs through labor, divided into three stages: the first stage involves cervical dilation from 0 to 10 cm, lasting 8-18 hours for first-time mothers; the second stage entails fetal descent and , typically 30 minutes to 2 hours; and the third stage is placental expulsion within 30 minutes. Multiples, such as twins, can arise from fraternal (dizygotic) pregnancies, where two eggs are fertilized separately, or identical (monozygotic) ones, from a single fertilized egg splitting, affecting placental sharing and potential complications like . Postnatally, infancy features rapid spurts, with newborns tripling by 12 months through accelerated and nutrient uptake. Developmental milestones include independent walking around 12 months, supported by maturation and practice. onset typically occurs between ages 10 and 14, triggered by hypothalamic-pituitary-gonadal axis activation, leading to secondary and a spurt of 8-10 cm annually. Health factors significantly influence ; adequate maternal and , including , supports optimal by providing essential fatty acids and antibodies, reducing risks of stunting and . , defined as under 2.5 kg, increases risks of neonatal mortality by 20 times and long-term issues like developmental delays and chronic diseases.

Social and Cultural Roles

In human societies, offspring play central roles within family structures, contributing to both nuclear and extended family dynamics. In nuclear families, typically consisting of parents and their dependent children, offspring are primary recipients of , emotional support, and economic provision, while also fostering parental bonds through caregiving responsibilities as they mature. Extended families, which incorporate grandparents, aunts, uncles, and cousins alongside the nuclear core, often assign offspring additional duties such as intergenerational caregiving and cultural transmission, enhancing family resilience in diverse socioeconomic contexts. Sibling relationships further shape these dynamics, serving as early models for , , and emotional intimacy; in interdependent cultures, such as many Asian and Latin American societies, siblings exhibit closer, more supportive ties compared to individualistic contexts, influencing lifelong . Through these interactions, offspring inherit and perpetuate family traditions, including values, rituals, and knowledge, which are transmitted vertically from parents and horizontally among siblings, ensuring cultural continuity across generations. Cultural practices surrounding human offspring vary widely, reflecting diverse beliefs about , integration, and maturation. Naming ceremonies, held shortly after birth in many traditions, formally introduce the to the and , often involving communal blessings or sacrifices to affirm the infant's place within the cultural lineage; for instance, the Hindu Namakaran ritual on the twelfth day includes priestly chants and family gatherings to bestow a name symbolizing virtues or ancestry. In Jewish communities, a Simchat Bat or may serve this purpose for girls and boys, respectively, emphasizing spiritual inclusion. Rites of passage mark the transition from childhood to adulthood, reinforcing social roles; the Bar Mitzvah for Jewish boys at age 13, involving and communal celebration, signifies religious responsibility and maturity, paralleling the Bat Mitzvah for girls at 12. Similar ceremonies, like the in Latin American cultures at age 15, highlight gender-specific expectations and ties, adapting to modern contexts while preserving core symbolic elements. Offspring significantly influence demographic trends, driving or decline based on patterns. The global stood at approximately 2.3 children per woman in 2023 and 2.2 in 2024, with projections indicating further declines; as of 2024, more than half of countries (approximately 55%) exhibit rates below the replacement level of 2.1, leading to slower and accelerated aging in societies like and much of , where shrinking youth cohorts strain pension systems and labor markets. In low-fertility contexts, fewer offspring exacerbate intergenerational imbalances, prompting policy responses such as family support incentives to sustain societal vitality. Contemporary issues highlight evolving ethical considerations in forming and protecting family ties with offspring. practices emphasize the child's best interests, with international frameworks like the 1993 mandating safeguards against trafficking and ensuring cultural continuity in intercountry cases, though ethical challenges persist in addressing birth and adoptee . raises concerns over exploitation, particularly when commercial arrangements commodify women's bodies or obscure parental clarity; reports warn that such practices can violate child by risking loss or sale-like transactions, advocating for to prioritize over profit. The 1989 on the Rights of the Child (UNCRC) underpins these protections, affirming parental responsibilities (Article 18), safeguards (Article 21), and defenses against exploitation (Articles 19, 32, 34), ratified by nearly all nations to uphold offspring's in familial and societal contexts.

Genetic Inheritance

Mendelian Principles

In the 1860s, Gregor Mendel conducted pioneering experiments on pea plants (Pisum sativum) to investigate the inheritance of traits in offspring. By cross-pollinating true-breeding plants that differed in specific characteristics—such as seed color (yellow vs. green), seed shape (round vs. wrinkled), or plant height (tall vs. short)—Mendel observed consistent patterns in the resulting hybrid offspring. In the first filial generation (F1), hybrids typically displayed a single dominant trait, masking the recessive one; for instance, crossing yellow-seeded plants with green-seeded ones produced all yellow-seeded F1 offspring. Mendel's analysis of the second filial generation (), obtained by self-pollinating F1 hybrids, revealed a 3:1 phenotypic ratio of dominant to recessive , indicating that do not blend but are inherited as units. These experiments demonstrated two fundamental laws of . The Law of Segregation states that each individual possesses two for a given , which separate during formation so that each carries only one ; then combines these randomly in . The Law of Independent Assortment further posits that for different segregate independently during formation, provided the genes are on separate chromosomes, leading to new combinations in ./16:_Inheritance_and_Biotechnology/16.02:_Mendels_Experiments_and_Laws_of_Inheritance) To predict offspring genotypes and phenotypes under these principles, the —a diagrammatic tool developed by in —visualizes combinations from parental gametes. For a between two heterozygous parents (e.g., Rr × Rr, where R is dominant for round seeds and r is recessive for wrinkled), the square yields a 1:2:1 genotypic (RR:Rr:rr) and a 3:1 phenotypic (round:wrinkled)./03:_Genetics/3.06:_Punnett_Squares)
Rr
RRRRr
rRrrr
In a (e.g., RrYy × RrYy, tracking shape and color), the expands to a 4×4 grid, predicting a 9:3:3:1 phenotypic ratio among offspring (round yellow : round green : wrinkled yellow : wrinkled green), illustrating independent assortment. These Mendelian principles enable breeders and geneticists to forecast offspring traits in simple inheritance scenarios, such as agriculture or selective breeding programs, by applying the laws and tools to controlled crosses.

Molecular Mechanisms

The molecular basis of inheritance in offspring begins with deoxyribonucleic acid (DNA), which serves as the primary carrier of genetic information. DNA is structured as a double helix composed of two antiparallel strands of nucleotides linked by phosphodiester bonds, with the strands held together by hydrogen bonds between complementary base pairs: adenine (A) with thymine (T), and guanine (G) with cytosine (C). Genes, the functional units of heredity, consist of specific nucleotide sequences within this DNA that encode instructions for synthesizing proteins through the central dogma of molecular biology, where genetic information flows from DNA to messenger RNA (mRNA) via transcription, and then to proteins via translation. This process ensures that traits are passed from parents to offspring by replicating the double helix during cell division, with each daughter cell receiving an identical copy of the parental DNA. A key mechanism generating in offspring is , a specialized that produces haploid s from diploid parent cells. consists of two divisions, but the reduction to haploid occurs primarily during meiosis I, where homologous chromosomes pair and exchange genetic material. In I, the longest phase, chromosomes condense, the breaks down, and homologous chromosomes align to form synaptonemal complexes, facilitating crossing over—reciprocal exchanges of DNA segments between non-sister chromatids at chiasmata. This crossing over, mediated by double-strand breaks and repair proteins like Spo11, introduces recombination that shuffles alleles, ensuring each carries a unique combination of parental genes. Subsequent phases— I, I, and I—separate homologs, while II mirrors to yield four haploid s, each with half the number. Beyond the DNA sequence itself, modulates by altering without changing the code, thereby influencing phenotypes. , such as —the addition of groups to bases in CpG dinucleotides—typically repress transcription by recruiting repressive proteins that compact and block access to promoters. These marks can be heritable across generations if they evade reprogramming in the , allowing environmental exposures in parents to affect traits, such as responses or metabolic adaptations. For instance, patterns established in sperm or eggs persist in the , guiding developmental activation and contributing to phenotypic variation independent of sequence changes. Mutations introduce permanent alterations in DNA that drive evolutionary variation and can be inherited if occurring in gametes. Point mutations involve the substitution of a single nucleotide, which may be silent (no amino acid change), missense (altered amino acid), or nonsense (premature stop codon); a classic example is the missense mutation in the HBB gene causing sickle cell anemia, where adenine replaces thymine, substituting valine for glutamic acid in hemoglobin and conferring malaria resistance in heterozygotes. Insertion mutations add one or more nucleotides, often causing frameshifts that disrupt the reading frame and lead to nonfunctional proteins, while deletions remove nucleotides with similar disruptive effects. These mutation types, arising from errors in replication or environmental damage, provide the raw material for natural selection, with beneficial variants increasing diversity in offspring populations.

Advanced Reproduction Techniques

Cloning

Cloning represents an artificial method to produce genetically identical offspring, primarily through laboratory techniques that replicate the genetic material of a donor without . This process creates clones that are exact copies at the DNA level, offering potential applications in , , and , though it remains controversial due to technical challenges and ethical implications. As an artificial analog to natural observed in certain and , bypasses fusion to generate offspring from cells. Reproductive cloning seeks to produce a complete, viable organism genetically identical to the donor, while therapeutic cloning focuses on generating embryonic stem cells or tissues for medical treatments, such as organ repair, without developing a full organism. The landmark achievement in reproductive cloning was the birth of Dolly the sheep in 1996, the first mammal cloned from an adult somatic cell using nuclear transfer from a mammary gland cell of a six-year-old Finn-Dorset ewe. Dolly's creation demonstrated that differentiated adult cells could be reprogrammed to support full-term development, challenging prior assumptions about cellular irreversibility. Therapeutic cloning, in contrast, has advanced stem cell research but does not aim for live births. The primary technique for cloning is (SCNT), which involves several key steps to reprogram a donor . First, the is removed from an unfertilized () through enucleation, creating a cytoplast. Next, the from a (body) cell of the donor organism is isolated and inserted into the enucleated , often via or electrofusion. The reconstructed egg is then activated—typically with electrical or chemical stimuli—to initiate embryonic development, allowing it to divide into a stage . Finally, the is implanted into a mother's , where it develops into a and, if successful, a cloned offspring. This process, as used in Dolly's case, requires precise control to overcome epigenetic barriers that prevent proper in the donor . As of 2025, SCNT efficiencies have reached ~30% full-term development in select mammals using combined epigenetic treatments. Ethical concerns surrounding center on and broader ecological impacts. In reproductive cloning, low success rates—often below 5% in mammals—result in high numbers of failed embryos, premature births, and abnormalities like large offspring syndrome, causing significant suffering to surrogate animals and clones. For instance, developed arthritis at age 5 and was euthanized at 6.5 years due to progressive lung disease; while she had shortened telomeres, no direct link to her cloning was established, and her cloned 'siblings' have shown normal health. Additionally, widespread use of cloning in or could reduce by favoring identical copies over natural variation, exacerbating vulnerability to diseases and environmental changes, thus contributing to . Human reproductive faces global opposition, with the adopting a non-binding Declaration on Human Cloning in that prohibits all forms incompatible with human dignity, passed by a vote of 84 in favor, 34 against, and 37 abstentions. Many countries, including the and members of the , have enacted legal bans on , reflecting concerns over psychological harm to clones, , and violations of reproductive . By 2025, advances in SCNT have notably improved efficiency in mammals, though challenges persist. Epigenetic reprogramming strategies, such as injecting Kdm4d mRNA to reduce barriers, have boosted formation rates to over 40% in and increased live birth rates in species like pigs and . Robotic-assisted enucleation has achieved 95% success in removing nuclei while minimizing cytoplasmic damage, doubling cleavage rates compared to manual methods. Treatments like (TSA) and chaetocin have enhanced and , leading to higher rates in bovine and porcine . Despite these improvements, no confirmed cases of reproductive have occurred, with technical inefficiencies, ethical prohibitions, and international bans preventing its realization.

Assisted Reproductive Technologies

Assisted reproductive technologies () encompass a range of medical procedures designed to address and facilitate the and birth of offspring through interventions that support or replace natural fertilization processes. These technologies primarily aid couples or individuals facing challenges such as ovulatory disorders, low count, or blocked fallopian tubes, enhancing the likelihood of successful while preserving from parental gametes. By 2025, ART has become a cornerstone of modern , with ongoing advancements in and improving outcomes. As of 2025, AI tools for embryo selection have further improved ART outcomes. In vitro fertilization (IVF) represents the most widely utilized method, involving several key stages to achieve outside the body before transferring the resulting to the . The process begins with ovarian stimulation, where hormones are administered to produce multiple , followed by egg retrieval via ultrasound-guided from the ovaries. Retrieved eggs are then fertilized with in a setting—either through conventional or intracytoplasmic sperm injection (ICSI), where a single is injected directly into an —allowing embryos to develop for 3-5 days. Selected embryos are subsequently transferred to the , with any surplus often cryopreserved for future use. Success rates for IVF vary by age and clinic, averaging around 30% live per cycle for women under 35 in 2023 data, though rates decline to about 10% for those over 40 due to factors like egg quality. Beyond IVF, other ART modalities include intrauterine insemination (IUI), where specially prepared is placed directly into the uterus to increase fertilization chances during timed , often combined with ovarian stimulation for higher efficacy and used as a less invasive first-line option with success rates of 10-20% per cycle. involves a gestational carrier bearing the for intended parents, utilizing embryos created via IVF from the couple's or donors' , and is particularly relevant for those with uterine issues or same-sex couples. and further expand access, providing gametes from screened donors to recipients with gamete deficiencies, ensuring genetic continuity where possible while adhering to protocols in many jurisdictions. These methods collectively address diverse etiologies, with IUI and donation often preceding or complementing IVF. Preimplantation genetic testing (PGT) integrates seamlessly into IVF workflows to screen embryos for chromosomal abnormalities or specific genetic disorders before transfer, thereby reducing the risk of or inherited conditions. PGT-A (for ) analyzes embryo chromosomes to select euploid ones, improving implantation rates by up to 15-20% in cases, while PGT-M targets monogenic diseases like . This technology, refined through next-generation sequencing, exemplifies how incorporates to optimize offspring health without altering the . Adoption of PGT has surged, with over 50% of U.S. IVF cycles incorporating it by 2023. Globally, has resulted in over 15 million babies born by 2025, with cumulative IVF births exceeding 13 million by 2023, based on estimates. Regulations vary significantly; for instance, many European countries impose age limits (typically 40-50 for women) and caps (one or two per cycle) to mitigate multiple risks, as outlined in the EU Tissues and Cells Directive (2004/23/EC). In contrast, the U.S. features clinic-specific guidelines without federal mandates, fostering innovation but also disparities in affordability and equity. These frameworks underscore ART's ethical balancing of accessibility, safety, and societal impact.

References

  1. [1]
    Offspring: The Kids Are Alright - Rolling Stone
    Sep 22, 1994 · The Offspring went on to release a homemade EP and an album on the independent Nemesis Records. It sold 2,000 copies. Epitaph Records, an indie ...Missing: achievements | Show results with:achievements
  2. [2]
    The Offspring - Music Publishing - Concord
    The Offspring have performed over 1100 shows across the globe and sold more than 40 million albums worldwide. Their 1994 release Smash remains the highest- ...
  3. [3]
    A Guide on the Musical Journey of Offspring Band Members - GigWise
    Sep 22, 2024 · As of 2021, The Offspring's lineup consists of founding members Dexter Holland (lead vocals, guitar) and Kevin “Noodles” Wasserman (lead guitar) ...
  4. [4]
    THE OFFSPRING TAPPED FOR SUPPORT FOR THE WHO'S FINAL ...
    Sep 16, 2025 · The band's lineup consists of lead vocalist and rhythm guitarist Dexter Holland, lead guitarist Noodles, bassist Todd Morse, drummer Brandon ...
  5. [5]
    The Offspring's 'Smash': The Little Punk LP That Defeated the Majors
    Apr 8, 2014 · Both parties, however, went on to experience further success – the Offspring have had a run of successful albums, most recently 2012's Days Go ...Missing: achievements | Show results with:achievements
  6. [6]
    The Offspring Have Two New Platinum Singles - Loudwire
    Sep 23, 2021 · The Offspring have just seen two more of their singles reach platinum status, as certified by the RIAA, with “The Kids Aren’t Alright” and “You’re Gonna Go Far ...
  7. [7]
    The Offspring Still Fly as 'Days Go By' Rises on Rock Charts - Billboard
    May 21, 2012 · The band has notched 16 top 10s on the Alternative chart since then, including three No. 1s, the most recent being “You're Gonna Go Far, Kid,” ...
  8. [8]
    The Offspring hometown, lineup, biography - Last.fm
    Mar 31, 2025 · They have sold over 34 million albums worldwide, making them one of the best-selling punk rock acts of all time. Each album since the release of ...
  9. [9]
    Offspring Interview: Dexter Holland on New Album - Billboard
    Apr 16, 2021 · With 17 top 10s on alternative radio and 15 on mainstream rock, the band isn't slowing down yet: its first album on Concord Records, Let the Bad ...
  10. [10]
    The Offspring Announce Massive Supercharged Worldwide In '25 ...
    Mar 3, 2025 · They have sold over 40 million records worldwide, making them one of the best-selling rock bands in history.
  11. [11]
    Offspring - Etymology, Origin & Meaning
    Old English ofspring "children or young collectively, descendants," literally "those who spring off (someone)," from of "away, away from" (see off (prep.)) + ...
  12. [12]
    Progeny - Etymology, Origin & Meaning
    Originating from Latin progenies, meaning descendants or lineage, early 14c. "early" relates to offspring, family, and ancestry, reflecting its root in ...
  13. [13]
    Issue - Etymology, Origin & Meaning
    Issue originates from Old French "issue," meaning "a way out," derived from Latin "exire" (to go out). It means to flow out, exit, or supply.
  14. [14]
    Scion - Etymology, Origin & Meaning
    Originating c.1300 from Old French "sion, cion" meaning "descendant, shoot, twig," scion refers to a shoot for grafting or figurative offspring.
  15. [15]
    Proles - Etymology, Origin & Meaning
    proles (n.) "offspring," a dictionary word, 1670s, from Latin proles "offspring, progeny" (see prolific).
  16. [16]
  17. [17]
    OFFSPRING Definition & Meaning - Merriam-Webster
    The meaning of OFFSPRING is the product of the reproductive processes of a person, animal, or plant : young, progeny. How to use offspring in a sentence.<|control11|><|separator|>
  18. [18]
    Offspring - Oxford Reference
    New individual organisms that result from the process of sexual or asexual reproduction. See also F1; F2. From: offspring in A Dictionary of Biology ».
  19. [19]
    Offspring Definition and Examples - Biology Online Dictionary
    Jan 29, 2020 · Reproductive mature adults should be producing viable offspring in order to continue the existence of the species and pass on genetic information from ...
  20. [20]
    OFFSPRING - The Law Dictionary
    Find the legal definition of OFFSPRING from Black's Law Dictionary, 2nd Edition. This term is synonymous with "issue." See Barber v.
  21. [21]
    BROOD Definition & Meaning - Merriam-Webster
    The meaning of BROOD is the young of an animal or a family of young; especially : the young (as of a bird or insect) hatched or cared for at one time.
  22. [22]
    PROGENY Definition & Meaning - Merriam-Webster
    1. a : descendants, children b : offspring of animals or plants 2. outcome, product 3. a body of followers, disciples, or successors.
  23. [23]
    Binary Fission and other Forms of Reproduction in Bacteria | CALS
    Some other bacterial lineages reproduce by budding. Still others form internal offspring that develop within the cytoplasm of a larger "mother cell". The ...
  24. [24]
    Sexual Reproduction - OpenEd CUNY
    Fusion of the gametes gives rise to a fertilized egg cell, or zygote. The zygote will undergo multiple rounds of mitosis to produce a multicellular offspring. ...
  25. [25]
    Meoisis – Introduction to Living Systems
    Sexual reproduction is the production of haploid cells and the fusion of a haploid cell from each genetic parent to form a single, unique diploid cell, called a ...
  26. [26]
    Biology 2e, Genetics, Meiosis and Sexual Reproduction, The ...
    To summarize, meiosis I creates genetically diverse gametes in two ways. First, during prophase I, crossover events between the nonsister chromatids of each ...
  27. [27]
    [PDF] CHAPTER 13 MEIOSIS AND SEXUAL LIFE CYCLES
    Crossing over, by combining DNA inherited from two parents into a single chromosome, is an important source of genetic variation. • At metaphase II, ...
  28. [28]
    Meiosis & Sex at the Cellular Level - csbsju
    Nov 5, 2004 · In animals, sexual reproduction involves the production of sex cells (gametes) during meiosis followed by their subsequent fusion ( ...Missing: diversity | Show results with:diversity
  29. [29]
    Plant Reproduction | Organismal Biology
    The phenomenon of double fertilization, or two fertilization events, is unique to angiosperms and does not occur in any other type of plant or other organism.
  30. [30]
    Biology 2e, Plant Structure and Function, Plant ... - OpenEd CUNY
    A pollen grain adheres to the stigma In angiosperms, one sperm fertilizes the egg to form the 2n zygote, and the other sperm fertilizes the central cell to form ...
  31. [31]
    Reproduction Methods - OpenEd CUNY
    The genetic diversity of sexually produced offspring is thought to give species a better chance of surviving in an unpredictable or changing environment.
  32. [32]
    SUE - Mixing the Gene Pool
    asexual. The advantage of sexual reproduction is that mixing the gene pool produces diversity, thereby thwarting parasites and predators who can not adapt ...
  33. [33]
    [PDF] Sex determination - e-Publications@Marquette
    Apr 24, 2012 · The mammalian Y chromosome contains the dominant male determinant sex-determining region on Y (Sry), a transcriptional regulator that ...
  34. [34]
    What is sex? | The Biology of Sex and Death (Bio 1220)
    Mammalian sex determination is determined genetically by the presence of X and Y chromosomes. Individuals who are homozygous for X (XX) are female and ...
  35. [35]
    Reproduction without sex (Asexual Reproduction)
    Bacteria and Archaea reproduce asexually, by simply dividing a parent cell into two new cells in a process called binary fission.
  36. [36]
    Sexual vs. Asexual Reproduction - Learn Genetics Utah
    Asexual reproduction generates offspring that are genetically identical to a single parent. In sexual reproduction, two parents contribute genetic information.Missing: adaptation | Show results with:adaptation
  37. [37]
    Reproduction, Heredity, and Variation
    Asexual reproduction is adaptive when environmental conditions are stable; it is a highly effective way for a genotype or lineage to 'out reproduce' other ...<|control11|><|separator|>
  38. [38]
    Aphids | MU Extension
    Aphid females are born pregnant and produce more females in a process called parthenogenesis. When the weather cools, aphids produce males and females that ...
  39. [39]
    [PDF] Fishery Science – Biology & Ecology - NET
    The most common reproductive strategy in marine ecosystems is oviparity. Approximately 90% of bony and 43% of cartilaginous fish are oviparous (See Types of ...
  40. [40]
    [PDF] Reproductive Evolution of Chondrichthyans
    Yolk-sac viviparity involves retention of fertilized eggs throughout development within the uterus with no additional maternal nutritional input beyond the yolk ...<|control11|><|separator|>
  41. [41]
    Understanding the evolution of viviparity using intraspecific variation ...
    Apr 14, 2025 · One of the most fundamental aspects of animal reproduction is parity mode: whether females lay eggs (oviparity) or give birth to live young ( ...
  42. [42]
    Animal Development II: Gastrulation & Organogenesis
    The eggs of amniotes also contain four additional extra-embryonic tissues: the amnion, chorion, allantois, and yolk sac, shown below. Extra-embryonic ...
  43. [43]
    Embryonic specializations for vertebrate placentation - PMC - NIH
    Oct 17, 2022 · The yolk sac is the classical extraembryonic membrane available for placentation in anamniotes and forms the embryonic portion of the placenta ...
  44. [44]
    Mother–Young Bonding: Neurobiological Aspects and Maternal ...
    Marsupials are another important example of altricial species since the young are born in an embryonic state and require to be carried by their mothers at all ...Missing: vertebrates | Show results with:vertebrates
  45. [45]
    Precocial
    "Precocial" and "altricial," two words describing the degree of development in young birds at hatching, are good examples of useful scientific jargon. They save ...Missing: vertebrates | Show results with:vertebrates
  46. [46]
    Fisheries-induced selection against schooling behaviour in marine ...
    Sep 30, 2020 · Here, we use an individual-based model to explore the evolution of fish schooling behaviour in a range of environments, including natural and ...Missing: vertebrates | Show results with:vertebrates
  47. [47]
    Parental Care Patterns of Fishes
    To increase the likelihood of paternity for offspring in which they invest parental care, males should attempt to deny rivals access to their mate(s). This is ...
  48. [48]
    Species-Specific Gamete Interaction during Sea Urchin Fertilization
    Sep 24, 2022 · In sea urchins, the sequence of the cellular and molecular events characterizing the fertilization process has been intensively studied.
  49. [49]
    43.2A: External and Internal Fertilization - Biology LibreTexts
    Nov 22, 2024 · Internal fertilization protects the fertilized egg or embryo from predation and harsh environments, which results in higher survival rates than ...
  50. [50]
    Butterfly Metamorphosis | American Museum Of Natural History
    The butterfly begins life as an egg, emerges as a caterpillar, and then undergoes a complete change in body form during development.
  51. [51]
    Red Sea Urchin (Mesocentrotus franciscanus) Printer Friendly
    Urchins are broadcast spawners with external fertilization and aggregate during spawning. Female urchins may produce 100,000 to 2,000,000 eggs into the sea ...Missing: strategies | Show results with:strategies
  52. [52]
    An Organismal Perspective on the Evolution of Insect Societies
    Social influence on age and reproduction: reduced lifespan and fecundity in multi−queen ant colonies. ... The relationship between adult size and brooding in ...
  53. [53]
    Egg sacs, spiderlings and dispersal - The Australian Museum
    The eggs of many spiders are glutinous and stick together allowing them to be laid in a continuous stream into the partly built silk egg sac. They vary in ...
  54. [54]
    Deep-Sea Octopus (Graneledone boreopacifica) Conducts the ...
    Jul 30, 2014 · In shallow-water species the eggs are often clustered within a den, where they are guarded and ventilated by the female. In pelagic species, ...
  55. [55]
    Moonrise timing is key for synchronized spawning in coral ... - PNAS
    Aug 9, 2021 · Synchronized mass coral spawning typically occurs several days after a full moon once a year. It is expected that spawning day is determined by ...
  56. [56]
    Section 2: Asexual Reproduction in Invertebrates - EdTech Books
    Fragmentation (L. fragmentum, “a piece”). Fragmentation occurs when an organism splits into multiple parts, each of which can regenerate into a complete ...
  57. [57]
    The Life Cycle of an Angiosperm - OpenEd CUNY
    A double fertilization event then occurs. One sperm and the egg combine, forming a diploid zygote—the future embryo. The other sperm fuses with the polar nuclei ...
  58. [58]
    [PDF] Angiosperms.pdf
    Double fertilization: In angiosperms, pollination results both in the fertilization of the egg to form a zygote, and also of the central cell to form a primary ...
  59. [59]
    [PDF] Seeds and Fruits - PLB Lab Websites
    14.2 GERMINATION​​ Germination, the first step in the growth of the embryo, begins with the uptake or imbibition, of water. This is a critical step because seeds ...
  60. [60]
    Seed Plants: Gymnosperms – Introductory Biology
    Gymnosperm characteristics include naked seeds, separate female and male gametes, pollination ... naked seeds (seeds exposed on modified leaves or in cones).
  61. [61]
    Lecture 26: Biology 102 - Portland State University
    Mar 9, 1998 · Gymnosperms (and flowering plants as well) produce pollen as a package for the dispersal of sperm. Gymnosperms disperse pollen on wind currents.
  62. [62]
    26.2 Gymnosperms – General Biology - UCF Pressbooks
    Characteristics of the gymnosperms include naked seeds, separate female and male gametes, pollination by wind, and tracheids (which transport water and solutes ...
  63. [63]
    Lab 8 - Primitive Plants - Bryophytes, Ferns and Fern Allies
    First, all plants undergo an alternation of generations, between a haploid gametophyte stage and a diploid sporophyte stage. In the most primitive plants, like ...
  64. [64]
    biological diversity: nonvascular plants and nonseed vascular plants
    Plants have an alternation of generations: the diploid spore ... Ferns reproduce by spores from which the free-living bisexual gametophyte generation develops.
  65. [65]
    Lab 9 - Gymnosperms and Angiosperms - Tulane University
    The wind pollinated gymnosperms needed large contiguous populations for effective pollination.<|separator|>
  66. [66]
    [PDF] How Bryophytes Impact Ecosystem Processes and Their Use in ...
    Jun 16, 2021 · Unlike vascular plants, bryophytes reproduce by spores rather than seeds which allows for greater dispersal ability (Gignac 2001, Patiño & ...
  67. [67]
    [PDF] Reproduction and Dispersal of Biological Soil Crust Organisms
    Oct 4, 2019 · Bryophyte spores are capable of surviving in the desiccated state for decades. Comparisons of spore desiccation tolerance and frost resistance ...
  68. [68]
    Embryology, Week 1 - StatPearls - NCBI Bookshelf
    Apr 17, 2023 · Week 1 is a major part of the germinal stage of development, a period of time that continues from fertilization through uterine implantation.
  69. [69]
    Embryology, Weeks 6-8 - StatPearls - NCBI Bookshelf
    Oct 10, 2022 · Introduction. In human embryology, weeks 6 through 8 are characterized by the growth and differentiation of tissues into organs.
  70. [70]
    Fetal development: MedlinePlus Medical Encyclopedia
    Aug 23, 2023 · Your baby's brain, spinal cord, and heart begin to develop. Your baby's gastrointestinal tract starts to form.
  71. [71]
    Human Growth and Development - StatPearls - NCBI Bookshelf
    Mar 8, 2023 · Stages in Human Growth and Development. Fetal stage: Fetal health issues can have detrimental effects on postnatal growth. One-third of ...
  72. [72]
    How Your Fetus Grows During Pregnancy - ACOG
    What happens during weeks 1 to 8 of pregnancy? The brain and spine begin to form. Cardiac tissue starts to develop. Muscles of the eyes, nose, and mouth form.
  73. [73]
    Definition of Term Pregnancy - ACOG
    Early term: 37 0/7 weeks through 38 6/7 weeks · Full term: 39 0/7 weeks through 40 6/7 weeks · Late term: 41 0/7 weeks through 41 6/7 weeks · Postterm: 42 0/7 ...
  74. [74]
    First and Second Stage Labor Management - ACOG
    The second stage of labor commences at 10 cm cervical dilation and ends on delivery of the neonate. The third stage of labor is the period between delivery of ...
  75. [75]
    Twin Study Design - PMC - PubMed Central - NIH
    Identical (i.e., monozygotic, or MZ) twins share 100 percent of their genes, whereas fraternal (i.e., dizygotic, or DZ) twins generally share only 50 percent ...
  76. [76]
    [PDF] Milestone Moments Booklet 2021 - CDC
    Milestones Matter!​​ Look inside for milestones to watch for in your child and tips for how you can help your child learn and grow from birth to age 5.Missing: human puberty
  77. [77]
    [PDF] Young Teens (12-14 years of age) - Growing Healthy Minds
    Hormones change as puberty begins. Most boys grow facial and pubic hair and their voices deepen. Most girls grow pubic hair and breasts, and start their period.Missing: infancy | Show results with:infancy
  78. [78]
    The importance of infant and young child feeding and recommended ...
    1.1.​​ Adequate nutrition during infancy and early childhood is essential to ensure the growth, health, and development of children to their full potential.Growth, health and development · The Global Strategy for infant...
  79. [79]
    Low birth weight - World Health Organization (WHO)
    Low birth weight infants are about 20 times more likely to die than heavier infants. Low birth weight is more common in developing than developed countries.
  80. [80]
    Nuclear Family Functions In Sociology - Simply Psychology
    Feb 15, 2024 · The nuclear family's functions include socialization, economic stability, reproduction, and regulating sexual behavior, and primary ...Key Takeaways · Economic · Alternative Family...
  81. [81]
    The Family in Cross-Cultural and Historical Perspectives
    Extended families, for example, which consist of parents, their children, and other relatives, have a nuclear family at their core and were quite common in the ...
  82. [82]
    Cultural variations in sibling relationships. - APA PsycNet
    This chapter focuses on what is known about children's and adolescents' sibling relationships in different cultural (ethnic and racial) contexts.Missing: significance | Show results with:significance
  83. [83]
    The Effects of Family Culture on Family Foundations
    Both in direct and subtle ways, children are molded by the family culture into which they are born.Missing: offspring | Show results with:offspring
  84. [84]
    Baby Naming Customs - Kybele
    Jan 1, 2013 · The namakaran ceremony is a Hindu tradition done usually on the twelfth day of a baby's life, if at all possible. It involves a gathering of ...Missing: practices | Show results with:practices
  85. [85]
    Bar and Bat Mitzvah 101 - My Jewish Learning
    At the bar/bat mitzvah, the child will generally get an aliyah and usually chant the haftarah (prophetic reading) as well. Many children also chant all or some ...Missing: naming | Show results with:naming
  86. [86]
    13 Amazing Coming of Age Traditions From Around the World
    Jul 21, 2016 · Coming of age traditions include Jewish Bar/Bat Mitzvahs, Sateré-Mawé bullet ant initiation, Amish Rumspringa, and the Japanese Seijin-no-Hi ...Missing: naming | Show results with:naming
  87. [87]
    Fertility Rate - Our World in Data
    Globally, the total fertility rate was 2.3 children per woman in 2023. This is much lower than in the past; in the 1950s, it was more than twice as high: 4.9.Replacement-level fertility rate · Why the total fertility rate... · Wanted fertility rateMissing: 2.1 | Show results with:2.1
  88. [88]
    Confronting the consequences of a new demographic reality
    Jan 15, 2025 · Two-thirds of humanity lives in countries with fertility below the replacement rate of 2.1 children per family. By 2100, populations in some ...
  89. [89]
    5 facts about global fertility trends | Pew Research Center
    Aug 15, 2025 · Globally, this is estimated to be around 2.1 births per woman, although this varies according to mortality rates. In Oceania, the fertility rate ...Missing: growth aging
  90. [90]
    [PDF] A/HRC/34/55 General Assembly - the United Nations
    Dec 22, 2016 · The 1993 Hague Convention on Protection of Children and Cooperation in Respect of Intercountry Adoption develops the principles set out in the ...
  91. [91]
    [PDF] A/HRC/37/60 General Assembly
    Feb 26, 2018 · The present study therefore examines when surrogacy arrangements constitute the sale of children under international human rights law and as ...
  92. [92]
    Convention on the Rights of the Child
    ### Summary of Key Articles on Child Rights (Family, Adoption, Protection from Exploitation)
  93. [93]
    [PDF] Mendel, Gregor. 1866. Versuche über Plflanzenhybriden. Verhand
    If two plants which differ constantly in one or several characters be crossed, numerous experiments have demonstrated that the common characters are transmitted ...
  94. [94]
  95. [95]
    "Experiments in Plant Hybridization" (1866), by Johann Gregor Mendel
    Sep 4, 2013 · Mendel used pea plants that, within a lineage, displayed only one physical characteristic, like a specific pod color or a specific seed shape, ...<|control11|><|separator|>
  96. [96]
    Monohybrid and Dihybrid Crosses | Texas Gateway
    A Punnett square makes working out the probabilities of inheritance easier. It is a boxed grid that lets you separate the versions of a trait, or alleles, from ...
  97. [97]
    Dihybrid cross and the law of independent assortment (video)
    Nov 9, 2021 · The probabilities of different offspring genotypes and phenotypes can be determined using a Punnett square. A dihybrid cross results in a roughly 9:3:3:1 ...
  98. [98]
    A Structure for Deoxyribose Nucleic Acid - Nature
    Molecular Structure of Nucleic Acids: A Structure for Deoxyribose Nucleic Acid. J. D. WATSON &; F. H. C. CRICK. Nature volume 171, pages 737–738 ( ...
  99. [99]
    Central Dogma of Molecular Biology - Nature
    Aug 8, 1970 · The central dogma of molecular biology deals with the detailed residue-by-residue transfer of sequential information.
  100. [100]
    Control of Meiotic Crossovers: From Double-Strand Break Formation ...
    In this review, we discuss the proteins involved in crossover formation, the process of their formation and designation, and the rules governing crossovers.Missing: paper | Show results with:paper
  101. [101]
    Epigenetic inheritance of acquired traits through DNA methylation
    Dec 17, 2021 · DNA methylation, a controversial epigenetic inheritance, involves adding a methyl group to Cytosine. It can be intergenerational (F0-F1) or ...
  102. [102]
  103. [103]
    Mutation, Repair and Recombination - Genomes - NCBI Bookshelf
    Many mutations are point mutations that replace one nucleotide with another; others involve insertion or deletion of one or a few nucleotides. Mutations result ...