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Lychee

The lychee (Litchi chinensis), also spelled litchi, is a subtropical tree in the soapberry family , native to southern , where it has been cultivated for over 2,000 years. The tree typically reaches 30–50 feet (9–15 m) in height with a dense, round canopy of glossy, dark green, pinnate leaves that emerge bronze-red before maturing to 5–8 inches (12–20 cm) long. Its fruit is a small, round to heart-shaped , about 1–1.5 inches (2.5–4 cm) in diameter, featuring a rough, brittle, strawberry-red rind that encases translucent, juicy white flesh with a sweet, floral flavor and a single large, dark brown seed. Originating from the Guangdong and Fujian provinces of , lychee has spread widely through cultivation to tropical and subtropical regions worldwide, including , , , , , , and parts of the , thriving in USDA zones 10A–11 with full sun, deep well-drained soils, and annual rainfall of 60–140 inches (150–350 cm). The tree flowers in spring with small, fragrant greenish-white panicles, producing fruit 3–5 months later in late spring to summer, though bearing can be irregular due to environmental factors like temperature fluctuations. Wild populations persist in southern and Hainan Island, but commercial production is dominated by , which accounted for about 84% of global output as of 2023, followed by and . Lychee is propagated primarily by air-layering and grown for its ornamental value as a shade or specimen , as well as for fresh consumption, with popular cultivars including 'Brewster', '', 'Groff', and 'Kwai Mi' selected for flavor, size, and yield. The is non-climacteric, harvested when fully ripe, and valued for its delicate taste in desserts, beverages, and canned products, though it has a short post-harvest. Economically, it supports a multibillion-dollar , with challenges including susceptibility to pests like lychee erineose and diseases such as anthracnose. Nutritionally, fresh lychee is low in calories and sodium, providing about 72 mg of (80% daily value) per 100 g serving, along with , , and , contributing to its role in traditional Asian for ailments like coughs and digestive issues using leaves, seeds, and pericarp. Despite its appeal, raw lychee consumption has been linked to hypoglycemic risks in undernourished children due to hypoglycin A in the seeds, prompting health advisories in some regions.

Taxonomy

Classification

The lychee belongs to the monotypic genus Sonn., which contains only a single species and is placed within the soapberry family Juss. This family is part of the order Juss. ex Bercht. & J.Presl, which falls under the subclass Takht., class Magnoliopsida Bartl., and kingdom Plantae Haeckel. The genus Litchi is characterized by its trees bearing small, fleshy fruits with a rough, pink-red exterior, distinguishing it from other Sapindaceae members like the related (Dimocarpus longan). The sole species, Litchi chinensis Sonn., was formally described by the French naturalist Pierre Sonnerat in his 1782 publication Voyage aux Indes Orientales et à la Chine, marking the first detailed botanical account of the plant. This tropical evergreen tree is native to southern China and surrounding regions, with its classification reflecting its position among angiosperms in the eudicots clade. Three subspecies are currently accepted within L. chinensis: L. chinensis subsp. chinensis (Sonn.), the primary cultivated form originating and grown extensively in South China; L. chinensis subsp. philippinensis (Radlk.) Leenh., which occurs wild in the Philippines and southeastern New Guinea; and L. chinensis subsp. javensis Leenh., found wild in Indonesia (Java), and known in cultivation in Malaysia. These subspecies differ subtly in fruit morphology, leaf characteristics, and geographic distribution, with subsp. chinensis being the most commercially significant.

Etymology

The English word "lychee" derives from the Classical Chinese term 荔枝 (lìzhī), the standard name for the fruit in Mandarin pronunciation, which entered European languages in the late 16th century via forms such as "lechia" or "lichea". The characters' etymology is uncertain, with first attestation in the late 3rd century BCE, but a common interpretation associates an alternative form 离枝 with "leaving the branch," referring to the fruit's tendency to detach easily from the stem during harvest. Recent linguistic studies, however, propose that 荔枝 is a disyllabic borrowing from a Kra-Dai language during the Late Old Chinese period, discounting earlier folk etymologies. According to the American Heritage Dictionary, the term traces to Middle Chinese *lɛ̀aX dzr̩ (lychee + branch), possibly alluding to the fruit's clustered growth on leafy twigs. The modern scientific binomial Litchi chinensis was established by French naturalist Pierre Sonnerat in his 1782 travelogue Voyage aux Indes Orientales et à la Chine, based on observations from his journeys to and , where he provided the first detailed Western description of the tree and fruit. This French-influenced spelling "litchi" became prevalent in and influenced subsequent English variants. Alternative English spellings include "litchi," "lichee," and "leechee," reflecting phonetic adaptations from the Cantonese pronunciation "lai6 zi1" (lahy-chee). In , where the fruit is widely cultivated, regional names include "lichi" in and "litchu" in Oriya, among other vernacular forms.

Description

Tree

The lychee (Litchi chinensis) is a long-lived typically growing to 10–15 meters in height, although mature specimens can reach up to 30 meters. It possesses a short, stocky up to 50 cm in diameter, often buttressed at the base, with smooth to gray bark. The forms a dense, rounded, and symmetrical canopy that extends nearly to the ground, providing effective shade. The leaves are pinnate and , 12.5–20 long, consisting of 4–8 alternate elliptic to lanceolate leaflets. These leaflets are glossy and dark green above when mature, glabrous on both surfaces, with immature leaves displaying a reddish or coloration before fully developing. The overall growth habit is slow to moderate, with trees often attaining around 9 meters in height after 30 years.

Flowers

The flowers of the lychee (Litchi chinensis) are borne on erect terminal panicles, which typically measure 30–65 cm in length and contain hundreds to thousands of tiny blooms. These inflorescences emerge in dense clusters at the ends of branches, with the panicles exhibiting a branched, thyrsoid structure that supports the sequential development of flowers. The individual flowers are small, measuring 2–3 mm in length, and range in color from white to yellowish-green; they lack petals but feature a cup-shaped with pubescent surfaces. Lychee flowers are morphologically hermaphroditic but functionally or , with three main types distinguished by their reproductive roles: staminate (purely ), and hermaphroditic forms that act as either or . Each flower possesses 6–10 stamens arranged in two whorls, with filaments that are often hairy and vary in length depending on the functional type—longer in staminate and early hermaphroditic flowers for better dispersal. The superior is bicarpellate, containing one to two ovules, and is topped by a simple with a two-lobed ; in female-functioning flowers, the anthers are non-dehiscent staminodes, while in types, the pistil is vestigial or non-functional. Flower is determined early in development and follows a typical sequence within dichasial units on the : initial (M1), followed by , and then secondary (M2), promoting . Pollination in lychee is primarily entomophilous, with insects such as bees (Apis spp.) serving as the main vectors, though flies and other insects may contribute. The species exhibits self-incompatibility at the pollen-pistil level, often resulting in low self-fruitfulness and necessitating cross-pollination from compatible cultivars for effective fruit set, despite some pollen viability in self-pollen. This reproductive strategy enhances genetic diversity but can limit yields in monoculture orchards without polliniser trees.

Fruit

The lychee is a fleshy, indehiscent borne in loose, pendulous panicles on the , typically measuring 3 to 5 in length and exhibiting an to round, sometimes heart-shaped morphology. Its outer rind is pink-red, rough-textured, and adorned with small, scale-like tubercles that provide a distinctive bumpy appearance, darkening to purple-brown tones as the fruit fully ripens. Enclosed within the rind is the edible aril, a translucent white, gelatinous pulp that surrounds a single large, shiny brown measuring 1 to 3.3 cm in length; the aril offers a sweet taste with floral notes, while the is inedible and toxic owing to the presence of and related compounds. Fruit development progresses from post-pollination enlargement to full maturity over approximately 3 months, during which the pericarp (rind) differentiates into epicarp, mesocarp, and endocarp layers while the aril expands rapidly in the final stages. The fruit's high perishability stems from its susceptibility to rapid post-harvest, resulting in pericarp browning and quality deterioration within days at ambient temperatures.

History

Domestication

The lychee (Litchi chinensis) is native to the subtropical regions of southern , particularly the provinces of , , , , and , where wild populations continue to exist in habitats. These wild trees thrive in humid, lowland and hilly areas, contributing to the species' that underpins modern cultivars. Human of the lychee began over 2,000 years ago in southern , with the earliest historical records appearing during the (206 BCE–220 CE). In 111 BCE, ordered the planting of lychee trees in the imperial gardens near the capital, marking one of the first documented attempts to cultivate the fruit outside its native range, though the effort failed due to cold weather. By the (618–907 CE), lychees had become a luxurious tribute item for the imperial court, with elaborate relay systems established to transport fresh fruits from southern orchards to the emperor in , highlighting their status as a symbol of prestige. A seminal on lychee , varieties, and uses was authored by scholar Ts'ai Hsiang in 1059 CE during the , representing the earliest comprehensive treatise on the fruit. Genomic analyses have revealed that lychee underwent two independent events from distinct wild populations, leading to the divergence of early- and late-maturing groups. One event traces to wild ancestors in , while the other occurred from wild populations in , both approximately 1,700 to 2,000 years ago, coinciding with intensified human selection during the late and subsequent dynasties. traces back ~2,200 years to the second century BCE, with wild populations having diverged ~18,000 years ago. These events involved genetic adaptations for fruit traits and flowering times, as evidenced by divergence in the highly heterozygous lychee genome.

Introduction to other regions

The lychee, originally domesticated in southern China over two millennia ago, began its spread beyond its native range in the 17th and 18th centuries through trade routes and colonial networks. It first reached Burma (modern-day Myanmar) by the end of the 17th century and was introduced to India via this route in the 18th century, initially taking root in the northeastern and eastern regions where the subtropical climate proved suitable. By the early 20th century, systematic efforts had established more reliable propagation methods in India, transforming it from an exotic import to a cornerstone of local horticulture and positioning the country as one of the world's leading producers alongside China. European colonial expansion facilitated lychee's introduction to other tropical and subtropical locales in the late . botanists, including Joseph François Charpentier de Cossigny de Palma, brought the fruit to Réunion Island in 1764 and to nearby shortly thereafter, where it adapted well to the island ecosystems and became integrated into agricultural practices. In the Americas, lychee arrived in the , including , around 1775 via British and earlier Spanish trade influences, with the fruit associating closely with immigrant communities. It reached in the United States before 1880, introduced through botanical exchanges from and the , marking the beginning of its cultivation in the . The 19th and 20th centuries saw further dissemination driven by Chinese diaspora and international horticultural initiatives, extending lychee cultivation across , , and . In countries like and , it spread organically through regional trade by the mid-19th century, becoming a commercial staple in diverse agroecological zones. Similarly, plantings emerged in around 1870, via 19th-century settlers, and over a century ago by migrants seeking familiar crops in new frontiers. Today, lychee is cultivated in more than 20 countries worldwide, reflecting its successful adaptation to varied subtropical environments through these historical pathways.

Cultivation

Growing conditions

Lychee (Litchi chinensis) thrives in subtropical to tropical climates characterized by high , with optimal growth occurring in regions featuring warm, wet springs and summers followed by cool, dry falls and winters. The tree prefers average temperatures between 20°C and 30°C (68°F–86°F) during the , but it requires a period of cooler winter temperatures around 10–15°C (50–59°F) to induce flowering. Lychee is frost-sensitive, with young trees suffering damage at temperatures as high as −2°C to 0°C (28–32°F) and mature trees tolerating down to −4°C (25°F) only briefly before experiencing leaf drop, dieback, or death. For water needs, lychee cultivation demands annual rainfall of 1,300–2,000 mm (50–80 inches), distributed primarily during the spring and summer for vegetative growth and fruit development, supplemented by in drier periods. A distinct dry winter period, ideally lasting 3–5 months without excessive moisture, is essential to promote flower induction and mitigate bearing tendencies, where heavy cropping one year alternates with light yields the next. Soil conditions must be well-drained and slightly acidic, with a range of 5.0–7.5 and ample to support health and uptake. The tree adapts to various textures from sandy loams to clays but performs best in those preventing waterlogging, and it requires full sun exposure for vigorous growth and fruit production. Elevations up to 600 m (2,000 ft) are suitable, though higher altitudes may enhance fruit quality in some subtropical areas.

Propagation and care

Lychee trees are primarily propagated vegetatively to preserve desirable traits and ensure uniformity, as seedlings exhibit high genetic variability and do not produce true-to-type , often taking over a decade to bear fruit. Air layering, the most widely used method, involves a , applying rooting , and wrapping it with moist sphagnum moss enclosed in plastic to encourage root development, typically yielding rooted in 2–3 months that can fruit within 3–5 years. Grafting onto rootstocks like 'Hak Ip' or 'Tai So' using techniques such as modified top-wedge is also common for faster establishment and disease resistance, though seeds are occasionally used for rootstock production despite their limitations. Upon transplanting air-layered or grafted , spacing of 6–10 meters (20–30 feet) between trees is recommended to allow for canopy development and air circulation, with young hardened off in partial shade before full sun exposure. begins in the first two years to promote a balanced structure, such as an open-center or central-leader form, and continues post-harvest by removing 6–12 inches of branches to maintain tree height at 3–6 meters, enhance penetration, and stimulate new fruiting wood. Fertilization employs balanced NPK formulas, like 12-5-14 with micronutrients, applied in split doses—higher nitrogen for young trees every 8 weeks, reduced before flowering to avoid excessive vegetative growth—with mature trees receiving 2–3 kg annually adjusted by soil tests. Irrigation is essential during and dry periods, providing regular to young trees while withholding it in fall or winter (6–8 weeks before anticipated flowering) to induce blooms in suitable subtropical climates. For fruit set management, chemical or thinners are applied to heavy panicles to improve size and quality, often combined with post-bloom or restriction. Harvest occurs when the fruit rind shifts from green to red or pink, typically from May to July in the , with clusters clipped several inches from the branch using poles over 3–4 weeks to minimize damage.

Cultivars

Lychee (Litchi chinensis) exhibits extensive , with hundreds of cultivars described worldwide, though only about 15 are commercially significant on a global scale. These varieties are primarily classified by time—early (May–June), mid-season (June–July), and late (July–August)—as well as qualities such as , profile, flesh recovery percentage, and . Early cultivars often prioritize rapid maturation and export potential, while late ones emphasize extended harvest periods and disease resistance; hybrids like 'Salathiel' have been developed for improved resilience to pests. In , the origin of domestication, prominent cultivars include 'Feizixiao' (also known as Fay Zee Siu), an early-maturing variety with fruits weighing 24–32 grams, featuring sweet, high-quality pulp and 77–82% flesh recovery, making it ideal for fresh markets. 'Kwai May' (or Kwai Mi) produces early-season fruits with green-red skin, crisp texture, and a balanced sweet-tart , often noted for its high proportion of small, aborted "chicken tongue" seeds that enhance edibility. Mid-season options like 'Haak Yip' yield 20–22 gram fruits with sweet, juicy flesh and 68–76% recovery, while late varieties such as 'No Mai Tsze' offer 21–28 gram fruits that are fragrant and sweet, with excellent shelf life due to 75–85% flesh content. 'Wai Chee', another late Chinese cultivar, produces smaller 16–18 gram fruits that are juicy and sweet but have lower 63–73% flesh recovery, limiting its use to local consumption. Indian cultivars reflect regional adaptations for heat tolerance and flavor preferences. 'Shahi' (or Shahijan) is an early variety with 20–25 gram fruits known for their juicy, pulp and crunchy , yielding 100–150 per and favored for its thin and blunt . 'Bedana' features round, thick-skinned fruits with small seeds and variants across early, mid, and late seasons, providing versatility in harvest timing. The 'China' cultivar, despite its name, is late-maturing in India with oblong, thick-skinned fruits containing bold seeds and soft, pulp, showing pinkish flushes tolerant to hot winds. Australian and South African selections emphasize large fruit size and export quality. 'Brewster', a mid-season Australian cultivar, produces 19-gram elliptical fruits with purplish-red skin, sweet flavor, and 72% flesh recovery, widely grown for its juicy interior. 'Kwai May Pink', adapted from Chinese stock, yields 18–22 gram mid-season fruits with firm, sweet pulp and 67–77% recovery, prized for its rough, pinkish skin and variable seed size. In South Africa and Florida, 'Mauritius' stands out as a popular mid-to-late variety with pink-skinned, floral-scented fruits of moderate size, offering reliable production and cross-pollination benefits when paired with others like 'Emperor'. 'Emperor', favored in Florida for its unusually large fruits and good taste despite a sizable seed, features distinctly bumpy skin and suits subtropical climates. Hawaiian cultivars highlight adaptations for Pacific island conditions, including early and late options for staggered harvests. '', an early (May–June ripening), produces large 24-gram heart-shaped fruits with smooth dark red skin, 19% total soluble solids for sweetness, and up to 33% shriveled seeds, enhancing overall quality. Mid-season 'Hak Ip' offers 17-gram egg-shaped fruits with dull red skin and 20% soluble solids, while late 'Groff' yields small 11-gram broad fruits with high 71% flesh and orange-red hue. 'Tai So', early-to-mid, provides 24-gram bright red elliptical fruits with 74% flesh recovery and a sweet-acid balance. These varieties often require air-layering to maintain true-to-type traits, differing from seed-grown plants.

Pests and diseases

Lychee trees (Litchi chinensis) are susceptible to several pests that can damage leaves, shoots, and fruits, leading to reduced yields in major producing regions such as and . The lychee erinose (Aceria litchii), an invasive eriophyid , is one of the most significant pests, causing erineum —hairy, abnormal growths on the undersides of leaves that distort foliage and impair . As of 2025, the lychee erinose remains a growing threat to production in subtropical regions such as . This spreads via wind, insects, or infested plant material and has been reported to severely impact young trees in subtropical areas. Fruit borers, particularly Conopomorpha sinensis (: Gracillariidae), tunnel into developing fruits, shoots, and leaves, causing larval feeding damage that leads to fruit drop and malformation. These borers are a major threat in and have implications for international trade. Other common pests include , which suck sap from tender shoots and transmit viruses, and scale insects such as green scale (Coccus viridis) and plumose scale (Morganella longispina), which infest stems and leaves, potentially causing dieback and . Diseases pose additional challenges, with fungal pathogens being predominant. Anthracnose, caused by gloeosporioides, is the primary disease affecting lychee fruits, manifesting as dark brown spots that enlarge and cause rot, particularly during wet conditions; susceptible cultivars like may experience total crop loss in severe outbreaks. , primarily from species such as P. palmivora, affects the root system in poorly drained soils, leading to tree decline, wilting, and death, and is rated as a moderate threat in regions like , . Viral diseases, including lychee ringspot virus, can cause leaf spotting and ring-like symptoms, though they are less commonly documented and often managed through . Effective management relies on (IPM) approaches to minimize chemical use and sustain production. For the erinose mite, cultural practices like defoliation of infested leaves, sanitation, and destruction of affected parts are essential, supplemented by miticides such as pyridaben and biological controls including predatory mites. borers are controlled through timely applications targeting eggs and larvae, combined with and removal of infested fruits. and scales respond to horticultural oils, insect growth regulators like , and natural enemies such as lady beetles. Anthracnose management involves preventive foliar sprays of copper-based fungicides, especially on vulnerable cultivars, while prevention emphasizes improved drainage, , and fungicides. measures, including inspections and treatments, are critical for preventing and spread in . In regions like , these strategies have helped mitigate yield losses, which can exceed 50% without intervention.

Uses

Culinary

Lychees are primarily consumed fresh, prized for their sweet, juicy, floral flavor and translucent white aril, which is typically peeled and eaten out of hand as a snack or added to fruit salads. In processed forms, lychees are canned in syrup for year-round availability and used in desserts or as a topping, while the dried fruit—known as "lychee nuts"—serves as a chewy snack similar to raisins, often enjoyed on its own or as a natural sweetener in teas. Culinary applications extend to a variety of desserts, such as sorbets and ice creams that highlight the fruit's aromatic profile, and beverages including cocktails like the lychee martini, which combines lychee syrup or purée with and . In , lychees feature in savory-sweet dishes, such as fresh salads with herbs and proteins or desserts incorporating for texture contrast. Post-harvest handling is crucial for maintaining quality in global trade; rapid cooling to 5°C immediately after harvest can extend to up to three weeks.

Medicinal and other

In , the fruit of the lychee (Litchi chinensis) has been used for centuries to relieve coughs, soothe sore throats through decoctions of the , , and , and to cool internal heat. The and seeds are employed to treat and related gastrointestinal issues. Beyond medicinal applications, lychee seed extracts are incorporated into for their anti-aging benefits, primarily due to and properties that help reduce wrinkles and protect against . The wood from lychee trees is valued for crafting furniture, carvings, and tool handles, while residues are commonly used as due to their high content and low production. The rind, or pericarp, serves as a source of natural dyes for textiles, yielding earthy tones through eco-friendly extraction processes. Emerging research highlights lychee's potential in nutraceuticals, attributed to its rich profile from phytochemicals like and phenolics, though it lacks FDA approval for therapeutic treatments.

Nutrition

Composition

The lychee fruit, specifically the edible of the raw fruit, is characterized by a high and moderate levels, contributing to its juicy texture and sweet flavor. Per 100 grams of fresh , it provides approximately 66 kcal of energy, primarily from , with 81.8 g of , 0.83 g of protein, 0.44 g of total , and 16.5 g of , of which 15.2 g are sugars and 1.3 g are . In terms of vitamins, lychee is particularly rich in , offering 71.5 mg per 100 g (about 79-95% of the daily value, depending on age and gender), along with smaller amounts of at 0.1 mg (6% ) and at 14 µg (4% ). These water-soluble vitamins support various metabolic functions when incorporated into a balanced . The mineral profile includes notable levels of at 171 mg (4% ), at 0.148 mg (16% ), and at 31 mg (4% ) per 100 g, while it is low in sodium (1 mg, 0% ) and iron (0.31 mg, 2% ). This composition positions lychee as a hydrating, low-sodium option suitable for diverse dietary needs.
NutrientAmount per 100 g% Daily Value*
Energy66 kcal3%
Water81.8 g-
Protein0.83 g2%
Total Fat0.44 g1%
Carbohydrates16.5 g6%
Sugars15.2 g-
Fiber1.3 g5%
Vitamin C71.5 mg79%
Vitamin B60.1 mg6%
Folate14 µg4%
Potassium171 mg4%
Copper0.148 mg16%
Phosphorus31 mg4%
Sodium1 mg0%
Iron0.31 mg2%
*Percent Daily Values are based on a 2,000-calorie diet for adults; values may vary. Data sourced from USDA FoodData Central for raw litchis (aril).

Phytochemicals

Lychee (Litchi chinensis) fruit is particularly rich in , including procyanidins A and B, epicatechin, , and , with the highest concentrations found in unripe fruit and the pericarp (rind). The pericarp also contains significant levels of anthocyanins, such as cyanidin-3-glucoside, which contribute to the fruit's characteristic red coloration. A low-molecular-weight known as oligonol, derived from oligomerized proanthocyanidins in the pericarp, has been identified and commercialized for its enhanced . In addition to these, the fruit features other throughout its tissues, while the seeds contain and fatty acids, such as those comprising up to 42% of seed . The total phenolic content in lychee pulp typically ranges from 200 to 500 mg equivalents (GAE) per 100 g fresh weight, varying by and maturity.

Health effects

Benefits

Lychees are a rich source of , providing approximately 71.5 mg per 100 grams, which meets about 95% of the daily recommended intake for adult females. This high content supports immune function by enhancing production and activity, aids synthesis for skin and tissue health, and acts as an to neutralize free radicals, potentially reducing the risk of chronic diseases such as heart disease and cancer. The polyphenols in lychees, including epicatechin and proanthocyanidins, exhibit anti-inflammatory effects by suppressing proinflammatory cytokines like IL-6 and production, as demonstrated in both studies and a with athletes undergoing intense . These compounds also offer cardioprotective benefits by reducing and improving vascular function, contributing to lower risks of cardiovascular conditions. further indicate that lychee-derived polyphenols, such as oligonol, improve blood sugar control in diabetic models by enhancing insulin sensitivity and protecting pancreatic beta cells. Additionally, in mouse models of , lychee pulp phenolic extracts provide hepatoprotection by alleviating oxidative damage and . Lychees contribute to due to their high of about 82% and support digestive health through their , which totals 1.3 grams per 100 grams and promotes regular bowel movements while fostering a balanced gut environment. in lychee , such as those in the and pericarp, show potential anticancer properties in laboratory studies by inhibiting tumor and inducing in models of breast, , and liver cancers, although human clinical trials remain limited.

Adverse effects

Lychees contain the toxins and methylenecyclopropylglycine (MCPG), the latter of which metabolizes to methylenecyclopropylacetic acid (), primarily in the edible and to a greater extent in the seeds, with concentrations notably higher in unripe fruit. These compounds act as competitive inhibitors of enzymes involved in β-oxidation, disrupting and leading to severe, potentially fatal , particularly when stores are depleted. Consumption of unripe lychees on an empty stomach has been linked to outbreaks of acute among undernourished children, manifesting as seizures, , and high mortality rates without prompt glucose treatment. In , , recurrent outbreaks occurred from 2014 to 2019, affecting over 100 children annually during the lychee season, with a notable 2014 event reporting 390 cases and 122 deaths. Similar hypoglycin-related outbreaks were documented in between 2004 and 2009, coinciding with lychee harvests and involving pediatric cases of acute syndrome. Public health authorities, including the CDC, recommend that at-risk groups such as undernourished children avoid consuming lychees—especially unripe ones—on an empty and ensure regular evening meals to maintain blood glucose levels, alongside seeking immediate medical care for symptoms like or altered . In adults and well-nourished individuals, adverse effects are rare but may include from overconsumption or allergic reactions such as in sensitized persons. Lychee seeds are highly toxic if ingested due to elevated levels and should be discarded.

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