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Mexiletine

Mexiletine is a class IB antiarrhythmic medication that functions as a voltage-gated sodium channel blocker, primarily indicated for the suppression of life-threatening ventricular arrhythmias, such as premature ventricular contractions (PVCs) and ventricular tachycardia.^[1] Structurally analogous to lidocaine—a local anesthetic with similar electrophysiologic properties—it is administered orally in capsule form, typically at doses of 150 to 200 mg two to three times daily, and exhibits use-dependent blockade that preferentially affects rapidly firing cardiac tissues.^[1]^[2] Its mechanism of action involves inhibiting the rapid inward sodium current during phase 0 of the cardiac action potential, thereby shortening the action potential duration and refractory period in ventricular myocytes, which helps restore normal heart rhythm without significantly impacting conduction velocity in healthy tissue.^[1] This selective action makes it particularly useful in ischemic or depolarized myocardium, where it reduces automaticity and excitability to prevent recurrent arrhythmias.^[2] Mexiletine is extensively metabolized in the liver via CYP1A2 and CYP2D6 enzymes, with a half-life of approximately 9 to 12 hours, and is excreted primarily through urine; therapeutic drug monitoring is occasionally recommended due to variability in plasma levels influenced by genetic polymorphisms and drug interactions.^[1]^[3] Beyond its core antiarrhythmic role, mexiletine has off-label applications in treating skeletal muscle channelopathies, including myotonia in myotonic dystrophy, where it alleviates stiffness and pain by stabilizing sodium channels in muscle fibers.^[1] It also shows efficacy in managing certain neuropathic pain conditions and peripheral neuropathies, though its use is limited by gastrointestinal side effects like nausea and dizziness.^[1] In specific genetic arrhythmias, such as long QT syndrome type 3, it is recommended as a first-line therapy to shorten the QT interval and prevent torsades de pointes, often in combination with beta-blockers.^[1]^[4] Originally developed in the late 1960s as a lidocaine analog for oral use, mexiletine received FDA approval in 1985 under the brand name Mexitil for documented ventricular arrhythmias refractory to other treatments.^[5]^[6] While its role in suppressing PVCs has diminished in favor of catheter ablation due to comparable or superior efficacy and lower risks, it remains a valuable option in resource-limited settings or for patients intolerant to alternatives, with ongoing research exploring derivatives like meta-hydroxymexiletine for improved safety profiles.^[7]^[8]

Medical Applications

Human Uses

Mexiletine is primarily indicated for the treatment of documented ventricular arrhythmias, including sustained ventricular tachycardia and frequent premature ventricular contractions (PVCs), especially in patients who have not responded adequately to other antiarrhythmic agents.^[9] This use stems from its role as a class IB antiarrhythmic drug that suppresses abnormal ventricular rhythms without significantly affecting normal cardiac conduction.^[10] Off-label applications of mexiletine include the management of myotonia in nondystrophic myotonias, such as myotonia congenita, where it reduces muscle stiffness and improves mobility.^[11] It has also shown efficacy in suppressing arrhythmias associated with long QT syndrome type 3 (LQT3) by shortening the QT interval and reducing life-threatening arrhythmic events.^[12] Additionally, mexiletine has been explored for painful diabetic neuropathy, particularly for stabbing, burning pain, or formication, with evidence of rapid symptom relief in responsive patients.^[13] Clinical evidence for mexiletine's efficacy in ventricular arrhythmias includes the International Mexiletine and Placebo Antiarrhythmic Coronary Trial (IMPACT) from the 1980s, which demonstrated its effectiveness in preventing frequent or complex post-myocardial infarction arrhythmias comparable to other agents, without the increased mortality risks seen in subsets of the Cardiac Arrhythmia Suppression Trial (CAST) for class IC drugs.^[14] For nondystrophic myotonias, a 2012 randomized trial reported significant improvements in patient-reported stiffness over placebo. A 2024 randomized trial found lamotrigine non-inferior to mexiletine in reducing myotonia symptoms, offering an alternative option.^[15]^[16] In LQT3, a 2016 multicenter study found mexiletine reduced arrhythmic events by over 60% alongside QTc shortening.^[17] For diabetic neuropathy, a 1997 double-blind trial showed significant pain reduction at 675 mg daily, with a large effect size versus placebo, though benefits were more pronounced in specific pain subtypes.^[13] Dosing typically begins at 200 mg orally every 8 hours, with titration up to 400 mg every 8 hours based on electrocardiographic monitoring and plasma concentrations, aiming for a therapeutic range of 0.5 to 2.0 mcg/mL to optimize efficacy while minimizing risks.^[18] Due to potential proarrhythmic effects from its sodium channel blockade, therapy requires careful ECG oversight, particularly in arrhythmia patients.^[10]

Veterinary Uses

Mexiletine is primarily used in veterinary medicine to treat ventricular arrhythmias in dogs and cats, often secondary to conditions such as dilated cardiomyopathy or toxin exposure.^[19]^[20] In dogs, it is commonly prescribed off-label for chronic management of premature ventricular complexes (PVCs) and ventricular tachycardia, particularly when responsive to lidocaine during acute episodes.^[20] For cats, its use is less frequent but includes similar indications for ventricular arrhythmias, with evidence supporting its safety even at higher experimental doses.^[21] Standard dosing protocols in dogs involve 4-8 mg/kg orally every 8-12 hours, typically administered with food to minimize gastrointestinal upset, and often in combination with beta-blockers like atenolol for enhanced efficacy.^[22]^[23] In cats, dosing is generally 5-10 mg/kg orally every 12 hours, with adjustments for renal impairment, and fixed doses of 6.25-12.5 mg per cat every 12 hours are also reported based on pharmacokinetic data favoring twice-daily administration.^[24]^[21] Monitoring typically includes serial Holter electrocardiography (ECG) to assess arrhythmia control and guide dose adjustments.^[23] Efficacy studies in dogs demonstrate significant suppression of ventricular arrhythmias, with one multicenter retrospective analysis showing an 80% response rate and a median reduction in ventricular premature complexes from 3,562 to 350 per 24 hours (approximately 90% decrease) following oral administration at around 7 mg/kg every 8-12 hours.^[23] In canine models of dilated cardiomyopathy, mexiletine has achieved 60-80% reductions in PVC frequency when used adjunctively.^[25] Limited data in cats indicate no adverse electrophysiological changes and mild heart rate reductions without inducing bradycardia, supporting its role in arrhythmia management despite rarer clinical application.^[21] Veterinary formulations of mexiletine are adapted from human capsules (e.g., 150 mg or 200 mg), with compounded oral suspensions or flavored liquids available for precise dosing in smaller animals like cats and toy-breed dogs to improve compliance.^[20] These off-label extensions leverage its sodium channel-blocking mechanism, akin to that in human arrhythmia therapy, but tailored to species-specific cardiac physiology.^[19]

Safety Profile

Adverse Effects

Mexiletine is associated with a broad range of adverse effects that can limit its clinical utility, primarily affecting the gastrointestinal, neurological, and cardiovascular systems.^[1] In controlled clinical trials, gastrointestinal disturbances such as nausea, vomiting, and heartburn were the most frequently reported, occurring in approximately 39% of patients, while neurological effects like dizziness and tremor affected 19-26% and 13%, respectively.^[10] Cardiovascular events, including bradycardia and hypotension, were less common, with incidences below 5%.^[26] Serious adverse effects include proarrhythmic reactions, which can worsen existing arrhythmias or induce new ones, reported in 3.8% of patients in controlled trials and up to 8-29% in broader literature reviews.^[26] Rare but severe risks encompass rare instances of hepatotoxicity, including acute liver injury or hepatic necrosis, and hematologic abnormalities like agranulocytosis or thrombocytopenia (0.06-0.16%).^[10] Rare but severe hypersensitivity reactions, including Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS), Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN), have been reported.^[27] Mexiletine carries a black box warning for increased mortality risk in patients post-myocardial infarction, based on findings from the Cardiac Arrhythmia Suppression Trial (CAST) demonstrating excess cardiac arrest and death with similar class I antiarrhythmics.^[9] Incidence data from post-marketing surveillance and clinical studies highlight gastrointestinal effects as the leading cause of discontinuation, with rates ranging from 16-40% across trials involving hundreds of patients.^[10] For instance, in three-month controlled trials comparing mexiletine to other antiarrhythmics (n=430), upper gastrointestinal distress led to withdrawal in about 20% of cases, underscoring its dose-dependent nature.^[26] Management strategies emphasize dose reduction or titration for mild gastrointestinal or neurological effects, with regular electrocardiographic monitoring to detect proarrhythmia early, particularly in patients with heart failure.^[1] Severe cases, such as seizures or significant hypotension, require immediate discontinuation and supportive care, including hemodialysis if necessary for toxin removal.^[10] In renal impairment, accumulation may exacerbate effects, necessitating adjusted dosing.^[26]

Contraindications and Drug Interactions

Mexiletine is contraindicated in patients with known hypersensitivity to the drug or to other amide-type local anesthetics, as severe allergic reactions may occur.^[28] It is also absolutely contraindicated in cases of cardiogenic shock, due to the risk of further hemodynamic deterioration, and in patients with pre-existing second- or third-degree atrioventricular (AV) block in the absence of a pacemaker, as it may exacerbate conduction abnormalities.^[10] Relative contraindications include severe heart failure (New York Heart Association class III or IV), where cautious use is advised due to potential worsening of cardiac function, and hepatic impairment, which necessitates dose reduction to approximately 25-30% of the normal dose to prevent accumulation and toxicity.^[29] In pregnancy, mexiletine is classified as category C by the FDA, with limited human data indicating no clear evidence of teratogenicity in animal studies but potential risks to the fetus warranting use only if benefits outweigh hazards.^[30] Major drug interactions involve cytochrome P450 (CYP) enzymes, primarily CYP1A2 and CYP2D6, through which mexiletine is metabolized. Inhibitors such as fluvoxamine (reducing clearance by 38%) or fluoxetine can increase mexiletine plasma levels by 30-50%, heightening the risk of toxicity including proarrhythmic effects and neurological adverse events.^[10] Amiodarone potentiates the risk of bradycardia and hypotension when co-administered with mexiletine, while bidirectional alterations occur with theophylline, where mexiletine increases theophylline levels by up to 72% (potentially causing toxicity) and theophylline may slightly decrease mexiletine exposure.^[10] Combination with other class I antiarrhythmics should be avoided due to additive effects on cardiac conduction.^[29] Monitoring recommendations include regular plasma level assessments (target 0.5-2 mcg/mL) when initiating or adjusting therapy with CYP inhibitors or inducers, such as rifampin which decreases mexiletine levels, to ensure efficacy and safety; additionally, ECG monitoring for conduction changes is essential in at-risk patients.^[10] These interactions may exacerbate certain adverse effects, such as those tied to its pharmacokinetics involving hepatic metabolism.^[28]

Pharmacology

Mechanism of Action

Mexiletine is classified as a class Ib antiarrhythmic agent that primarily exerts its therapeutic effects through use-dependent blockade of voltage-gated sodium channels, particularly the cardiac isoform Nav1.5, in ventricular myocytes. This blockade inhibits the inward sodium current responsible for the rapid depolarization phase (phase 0) of the cardiac action potential, resulting in a reduction in the maximum rate of depolarization (V_max). By preferentially binding to the open and inactivated states of the channel during repetitive depolarizations, mexiletine shortens the action potential duration (APD) and the effective refractory period (ERP), while increasing the ERP/APD ratio, which helps suppress ventricular arrhythmias without significantly prolonging repolarization.^[28]^[31]^[32] Electrophysiologically, mexiletine reduces the velocity of phase 0 depolarization with minimal impact on overall conduction velocity in cardiac tissue. In Purkinje fibers, it effectively suppresses early afterdepolarizations (EADs), which are implicated in the initiation of torsades de pointes and other arrhythmias, by stabilizing the membrane potential and preventing abnormal depolarizations triggered by sodium channel dysfunction. These effects are particularly pronounced in conditions involving enhanced late sodium current, where mexiletine restores normal repolarization dynamics.^[33]^[34] In addition to its primary sodium channel blockade, mexiletine exhibits weak inhibition of the rapid delayed rectifier potassium current (I_Kr) mediated by hERG channels, with an IC50 of approximately 3.7 μM, contributing to subtle modulation of repolarization under certain conditions. It also shares membrane-stabilizing properties with lidocaine, enhancing its local anesthetic-like effects on excitable tissues. In skeletal muscle, mexiletine exerts antimyotonic effects through blockade of voltage-gated sodium channels, reducing repetitive muscle discharges and improving relaxation in non-dystrophic myotonic disorders.^[35]^[36] The binding kinetics of mexiletine to sodium channels are characterized by fast association and dissociation rates, with a time constant for offset around 110 ms, allowing for rapid recovery from block at normal heart rates and use-dependent efficacy during tachyarrhythmias. This state-dependent preference for inactivated channels underlies its selectivity for ischemic or rapidly firing myocardium.^[37]^[32]

Pharmacokinetics

Mexiletine exhibits rapid oral absorption, achieving a bioavailability of approximately 88%. Peak plasma concentrations occur 2 to 4 hours post-administration, though food can delay this time to peak without substantially altering the total extent of absorption.^[38]^[39] The drug distributes widely throughout the body, with a volume of distribution of 5 to 7 L/kg. It is about 70% bound to plasma proteins, predominantly alpha-1-acid glycoprotein, and readily crosses the blood-brain barrier, contributing to observed central nervous system effects.^[40]^[41] Metabolism occurs primarily in the liver through cytochrome P450 enzymes, with CYP1A2 as the major contributor and CYP2D6 playing a minor role; key pathways include oxidation to form metabolites such as the active but minor p-hydroxymexiletine. The elimination half-life averages 10 to 12 hours but extends in hepatic impairment, potentially reaching 25 hours.^[42]^[27]^[1] Excretion involves minimal renal elimination, with only 10 to 15% of the dose recovered unchanged in urine; however, renal clearance increases under acidic urinary conditions and decreases with alkalinization. Steady-state conditions are generally reached within 2 to 3 days of consistent dosing. Plasma concentrations in the therapeutic range of 0.5 to 2 mcg/mL correlate with effective sodium channel blockade.^[27]^[43]

Chemistry

Chemical Structure and Properties

Mexiletine, chemically known as 1-(2,6-dimethylphenoxy)propan-2-amine, is a primary amine with the molecular formula C₁₁H₁₇NO and a molecular weight of 179.26 g/mol.^[44]^[28] Its structure features an ether linkage connecting a 2,6-dimethylphenyl ring to a propan-2-amine chain, distinguishing it as an orally active analog of lidocaine, which instead contains an amide bond.^[44] The compound appears as a white to off-white crystalline powder with a slightly bitter taste.^[10] It has a melting point of 203–205 °C for the free base, while the hydrochloride salt melts at approximately 200–205 °C.^[28]^[45] Mexiletine hydrochloride exhibits a pK_a of 9.2, indicating basic character, and a logP value of 2.15, reflecting moderate lipophilicity that contributes to its membrane permeability.^[28]^[10] It is freely soluble in water (approximately 8.25 mg/mL for the base, higher for the salt) and in ethanol (50 mg/mL for the salt).^[28]^[45]^[10] Mexiletine hydrochloride is the form used in pharmaceutical formulations, primarily as oral capsules in strengths of 150 mg, 200 mg, and 250 mg.^[10] The compound is stable under neutral conditions and recommended storage at room temperature (20–25 °C), protected from light, moisture, and heat to maintain integrity.^[10]^[46]

Synthesis

Mexiletine is synthesized primarily through a multi-step process starting from 2,6-dimethylphenol, which is reacted with propylene oxide in the presence of a base catalyst such as sodium hydroxide to form the intermediate 1-(2,6-dimethylphenoxy)propan-2-ol via ring-opening of the epoxide. This alcohol is then converted to the chloride using thionyl chloride, followed by nucleophilic substitution with ammonia to yield the free base of mexiletine, with an overall yield of approximately 70%.^[47] The process is scalable for industrial production and typically employs racemic mixtures, as the clinically used form is the racemate.^[47] Alternative synthetic routes include reductive amination of the ketone intermediate 1-(2,6-dimethylphenoxy)propan-2-one, prepared from 2,6-dimethylphenol and chloroacetone under basic conditions, using ammonia and a reducing agent like sodium cyanoborohydride or catalytic hydrogenation, offering good yields and milder conditions compared to chlorination steps.^[48] Mannich reaction variants from 2,6-dimethylphenol with formaldehyde and ammonia or ammonium salts can also generate beta-amino ketone intermediates, which are subsequently reduced to the target amine.^[49] The original synthesis was patented in 1968 by Boehringer Ingelheim, marking the initial laboratory development of the compound, with subsequent optimizations focusing on scalable processes.^[47] Although racemic mexiletine is standard, enantiopure forms can be prepared via chiral resolution techniques such as diastereomeric salt formation or preparative chromatography if required for specific applications.^[49] In synthesis, impurities such as unreacted epoxide or chlorination byproducts are controlled through purification steps including distillation or column chromatography, followed by formation of the hydrochloride salt via treatment with anhydrous hydrogen chloride in ethanol for isolation as white crystalline material with high purity (>99%).^[47]

History and Society

Development and Regulatory Approval

Mexiletine was developed in the late 1960s by Boehringer Ingelheim as an oral analog of lidocaine intended for antiarrhythmic use, with initial preclinical testing demonstrating its potential to suppress ventricular arrhythmias through sodium channel blockade.^[7] The compound received a patent in 1968, marking the start of focused research into its pharmacological properties during the early 1970s.^[7] The first clinical results from human trials emerged in 1973, confirming mexiletine's efficacy in reducing arrhythmias in patients with acute myocardial infarction, which paved the way for broader evaluation.^[7] Regulatory milestones followed, with first approval in several European countries in 1976 for treating ventricular arrhythmias under the trade name Mexitil, reflecting its established safety profile in European studies.^[43] In the United States, the Food and Drug Administration granted approval in December 1985 for documented ventricular arrhythmias that did not respond to other therapies, based on extensive phase III trials showing suppression of premature ventricular contractions.^[28] Post-approval developments in the 1990s were shaped by the Cardiac Arrhythmia Suppression Trial (CAST), which highlighted increased mortality risks with certain class I antiarrhythmics in post-myocardial infarction patients, leading to revised guidelines that limited mexiletine's routine use for asymptomatic ventricular ectopy despite its class Ib profile suggesting lower proarrhythmic potential.^[50] This era emphasized selective application, focusing early research on high-risk post-infarction arrhythmias while addressing gaps in long-term safety data. In the 2020s, regulatory expansions addressed unmet needs in rare conditions, including orphan drug designation by the FDA in 2010 for nondystrophic myotonia, followed by European Commission approval in 2018 for myotonic disorders under the brand Namuscla, supported by trials demonstrating reduced muscle stiffness.^[51]^[52] Recent studies from 2020 to 2025 have explored mexiletine's role in genetic arrhythmias, particularly SCN5A mutations associated with overlap syndromes like long QT type 3 and Brugada syndrome, showing benefits in correcting sodium channel dysfunction and shortening QT intervals in patient-derived models.^[53]^[31] These investigations highlight a shift toward precision applications in inherited channelopathies.

Society and Culture

Mexiletine is marketed under several brand names globally, with Mexitil serving as the primary historical brand, though it was discontinued in the United States in 2020 while generic versions remain available.^[54]^[55] In Europe, it is approved as Namuscla specifically for non-dystrophic myotonia, an orphan indication granted marketing authorization by the European Medicines Agency in 2018.^[28]^[52] Other international brands include Mexitilen and variants like Mexilen, with generic mexiletine hydrochloride capsules introduced in the 2000s following patent expiration.^[56]^[9] The drug is approved and available in numerous countries worldwide, including the United States, United Kingdom, and European Union member states, as well as others such as Australia, Canada, and parts of Asia and Latin America, reflecting its broad post-approval distribution since the late 1970s.^[57] In the US, periodic shortages occurred during the 2010s, particularly affecting 150 mg capsules starting around 2009-2010 due to manufacturing exits and delays in active pharmaceutical ingredient supply, prompting the use of compounding pharmacies to meet demand.^[58]^[59] Generic mexiletine remains affordable, with monthly costs typically ranging from $30 to $100 for standard doses, depending on dosage strength and pharmacy.^[60]^[61] Mexiletine is not classified as a controlled substance under any DEA schedule in the United States, allowing standard prescription access without additional regulatory restrictions.^[10] Ethical considerations arise from its off-label use in rare diseases like non-dystrophic myotonia and myotonic dystrophy type 1, where patient advocacy groups, such as the Myotonic Dystrophy Foundation, have promoted its adoption based on clinical evidence of symptom relief despite lacking initial FDA approval for these indications.^[11]^[62] The US FDA granted orphan drug designation for mexiletine in treating non-dystrophic myotonia in 2010, and supply chain challenges for these orphan uses persisted into 2023, including restricted access in some regions due to orphan exclusivity and manufacturing issues, exacerbating availability concerns for affected patients.^[51]^[63]^[64] Cultural references to mexiletine are limited outside medical contexts, though it is noted in major cardiology guidelines as a potential therapy for ventricular arrhythmias. The 2017 AHA/ACC/HRS Guideline for Management of Patients With Ventricular Arrhythmias recommends mexiletine as a Class IIa option for reducing arrhythmic events in long QT syndrome type 3 patients.^[65] The 2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure positions it as a Class IB antiarrhythmic that may be considered cautiously for refractory ventricular arrhythmias in heart failure patients, but without routine endorsement due to limited evidence.^[66] It is also used veterinarily in some countries for animal arrhythmias, contributing to its global accessibility.^[19]

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Mexiletine - an overview | ScienceDirect Topics
Class Ib (Sodium Channel Blockers with Rapid Association/Dissociation Kinetics) ... mexiletine, an antiarrhythmic drug that acts by blocking sodium channels.
[49]
A Practical and Efficient Route for the Highly Enantioselective ...
A practical and efficient procedure for the enantioselective synthesis of mexiletine analogues with use of 10% of spiroborate ester 6 as chirality transfer ...
[50]
Antiarrhythmic Mexiletine: A Review on Synthetic Routes to Racemic ...
This review presents a detailed report on the different synthetic routes to racemic and homochiral mexiletine developed in the last decades.
[51]
Effect of the Antiarrhythmic Agent Moricizine on Survival after ...
Jul 23, 1992 · Studies of mexiletine were inconclusive, but they showed a trend toward worsening mortality. Disopyramide did not improve survival after a ...
[52]
Search Orphan Drug Designations and Approvals - FDA
Generic Name: mexiletine. Date Designated: 09/02/2010. Orphan Designation: Treatment of nondystrophic myotonia. Orphan Designation Status: Designated.
[53]
Namuscla | European Medicines Agency (EMA)
Other information about Namuscla. Namuscla received a marketing authorisation valid throughout the EU on 18 December 2018.
[54]
Beneficial effects of chronic mexiletine treatment in a human model ...
Jun 27, 2023 · These findings demonstrate for the first time the therapeutic benefit of mexiletine in a human cardiomyocyte model of SCN5A overlap syndrome.
[55]
https://www.rxlist.com/mexitil-drug.htm
[56]
Mexitil (Mexiletine HCl): Side Effects, Uses, Dosage ... - RxList
MEXITIL (mexiletine hcl) did not impair fertility in the rat. Pregnancy. Teratogenic Effects. Pregnancy Category C. Reproduction studies performed with MEXITIL ...
[57]
Mexiletine | Drug Lookup | Pediatric Care Online - AAP Publications
In adult patients with hepatic impairment or hepatic congestion secondary to heart failure, dose adjustment may be required. Dosing: Altered Kidney Function ...<|control11|><|separator|>
[58]
Mexiletine | New England Journal of Medicine
Jan 1, 1987 · It has local anesthetic, anticonvulsant, and antiarrhythmic properties.5. Pharmacokinetics. Mexiletine is almost completely absorbed from the ...
[59]
Mexiletine - Wikipedia
Mexiletine is a medication used to treat abnormal heart rhythms, chronic pain, and some causes of muscle stiffness. Common side effects include abdominal ...
[60]
Mexiletine hydrochloride is back in 150-mg capsules - News - VIN
Apr 9, 2010 · That exodus from the market created a shortage that came to light last fall and particularly affected the availability of 150-mg capsules, the ...Missing: details | Show results with:details
[61]
Drug Shortage Detail: Mexiletine Hydrochloride Capsules - ASHP
Lannett did not provide a reason for the shortage. Teva had mexiletine capsules on shortage due to a delay in obtaining active pharmaceutical ingredient.Missing: 2010s compounding
[62]
https://www.myotonic.org/mexiletine-myotonia-new-use-old-heart-drug
[63]
Mexiletine Coupons 2025: Up to 80% Discount - SingleCare
The average counter price for Mexiletine is $228.36 per 90, 150mg capsules, but you can pay just $33.51 for 90, 150mg capsules with the SingleCare savings card.
[64]
Mexiletine for Myotonia: A New Use for an Old Heart Drug?
Oct 23, 2012 · The drug is not approved for treating either NDM or DM, but doctors can prescribe it “off label.” However, as with any drug, there are risks ...
[65]
Mexiletine's Path to Treating Myotonic Dystrophy - Business Wire
Jul 28, 2023 · The report forecasts the sales of mexiletine for Myotonic Dystrophy up to 2032. Additionally, it offers a comprehensive overview of late-stage ...
[66]
Continuedmisuse of orphan drug legislation: A life-threatening risk ...
Sep 13, 2025 · (Postema et al., 2020) . Newer anti-arrhythmic drugs have largely replaced mexiletine, but a small group of patients have no alternative. ...Missing: supply chain
[67]
2017 AHA/ACC/HRS Guideline for Management of Patients With ...
Systematic review for the 2017 AHA/ACC/HRS guideline for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: a ...
[68]
2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure
Apr 1, 2022 · The 2022 guideline is intended to provide patient-centric recommendations for clinicians to prevent, diagnose, and manage patients with heart failure.