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Calcium alginate

Calcium alginate is the calcium salt of alginic acid, a naturally occurring anionic polysaccharide composed of β-(1,4)-linked D-mannuronic acid and α-(1,4)-linked L-guluronic acid residues, primarily extracted from the cell walls of brown seaweeds such as Laminaria hyperborea and Macrocystis pyrifera.^[1]^[2]^[3] It forms a water-insoluble, hydrophilic gel through ionic cross-linking when sodium alginate solutions react with calcium ions (e.g., from calcium chloride), creating an "egg-box" structure where Ca²⁺ ions bind guluronic acid blocks for enhanced stability.^[1]^[2] This gelation process results in a nearly odorless, white to yellowish fibrous or granular powder that is insoluble in water, acids, and alkaline solutions but swells upon hydration, with molecular weights typically ranging from 60,000 to 700,000 Daltons and gel strengths varying based on the mannuronic/guluronic ratio.^[1]^[2]^[3] As a versatile biopolymer, calcium alginate exhibits biocompatibility, biodegradability, and pH sensitivity, making it suitable for diverse applications.^[2] In the food industry, it serves as a thickener, stabilizer, emulsifier, and gelling agent (E404), used in products like sauces, ice cream, restructured foods, and edible coatings to enhance texture, prevent syneresis, and extend shelf life.^[1]^[2]^[3] In biomedical contexts, its excellent water absorption, hemostatic properties, and ability to maintain a moist wound environment position it as a key component in dressings for managing exuding wounds, promoting healing, and delivering antimicrobials.^[4]^[2] Additionally, it finds use in drug delivery systems, tissue engineering scaffolds, wastewater treatment, and industrial texturizers due to its tunable mechanical properties and non-toxicity.^[2] As of 2023, global alginate production is estimated at around 55,000 tonnes annually, primarily from brown seaweeds.^[5]

Structure and Properties

Chemical Structure

Calcium alginate is the calcium salt of alginic acid, a naturally occurring linear polysaccharide that serves as a copolymer of β-D-mannuronic acid (M) and α-L-guluronic acid (G) residues, linked via 1→4 glycosidic bonds.^[6]^[7] This polymeric structure arises primarily from brown algae, where alginic acid forms the backbone, and the incorporation of calcium ions replaces sodium or other counterions to yield the insoluble calcium variant.^[8] The molecular arrangement features distinct block sequences, including homopolymeric MM blocks, GG blocks, and heteropolymeric MG segments, which contribute to the polymer's heterogeneous composition.^[9] The GG blocks, in particular, play a key role in enabling cooperative interactions that underpin the material's functional attributes.^[8] The typical molecular weight of calcium alginate spans 10,000–600,000 Da, a range that directly impacts its solution viscosity and gel strength.^[10] Variations in the M/G ratio, commonly ranging from 0.4 to 2.5 based on the source algae such as Laminaria or Sargassum, modulate the polymer's conformational flexibility and interaction potential.^[2] For instance, higher M content tends to yield more flexible chains, while elevated G proportions enhance rigidity.^[11] The defining feature of calcium alginate's structure is its ionic crosslinking, where divalent Ca²⁺ ions coordinate with carboxylate groups on adjacent G-blocks from multiple polymer chains, forming a junction zone analogous to the "egg-box" model.^[8] In this model, the planar arrangement of guluronate residues creates stable, cooperative binding sites that mimic the compartments of an egg carton, with each Ca²⁺ ion typically associating with up to four oxygen atoms from two G-blocks.^[12] This crosslinking mechanism ensures the gel-like integrity characteristic of calcium alginate.^[13]

Physical Properties

Calcium alginate appears as a nearly odorless, white to pale yellow fibrous or granular powder. Upon hydration, it forms elastic, transparent gels that are gelatinous and cream-colored.^[1] It is practically insoluble in water, acids, alkaline solutions, and organic solvents such as chloroform, ethanol, and ether, though it swells in water to form a gel matrix. Solubility can be achieved through ion exchange in dilute solutions of sodium bicarbonate or chelating agents like EDTA, which remove calcium ions and revert the polymer to a soluble form.^[1]^[14]^[15] The strength and elasticity of calcium alginate gels depend on the calcium ion (Ca²⁺) concentration and the mannuronic acid to guluronic acid (M/G) ratio of the parent alginate. Higher Ca²⁺ concentrations enhance gel firmness, while alginates with high guluronic acid content (low M/G ratio) produce stronger, more brittle gels compared to those with high mannuronic acid content, which yield more elastic structures; this arises from the "egg-box" binding of Ca²⁺ ions to guluronate blocks.^[2]^[16] The dry powder has a bulk density of approximately 1.6 g/cm³. Calcium alginate demonstrates thermal stability up to 200°C, with initial dehydration occurring below this temperature and polymer degradation starting around 250°C.^[17] Calcium alginate gels exhibit viscoelastic rheological properties, with shear-thinning (pseudoplastic) behavior under applied stress. In precursor alginate solutions (1–5% concentration), viscosity increases with polymer concentration and molecular weight, typically ranging from 100 to 10,000 cP for medium- to high-molecular-weight grades.^[18]^[19]

Chemical Properties

Calcium alginate exhibits ionotropic gelation through the coordination of divalent cations, particularly Ca²⁺, with the guluronic acid (G) blocks of alginate chains, forming stable "egg-box" structures that enhance gel integrity.^[20] This process favors Ca²⁺ over other divalent cations like Mg²⁺ due to its optimal binding affinity and resulting gel stability, while Sr²⁺, though capable of similar crosslinking, yields less biocompatible gels in physiological contexts.^[20] The selectivity arises from the ionic radius and coordination chemistry of Ca²⁺, which promotes efficient cross-linking without excessive rigidity.^[2] The material demonstrates pH-dependent stability, remaining intact across neutral ranges from pH 4 to 10, where the carboxyl groups on alginate maintain their ionized state for structural support.^[2] Below pH 3, exposure to strong acids protonates these groups, leading to degradation and release of alginic acid through hydrolysis of glycosidic bonds.^[21] In highly alkaline conditions above pH 11, alkaline hydrolysis disrupts the polymer backbone, causing gel dissolution.^[22] Calcium alginate possesses chelation capabilities, primarily via its carboxyl and hydroxyl groups, which form coordination complexes with heavy metal ions such as Pb²⁺ and Cd²⁺, facilitating their sequestration.^[23] This binding exhibits selectivity, with Pb²⁺ showing higher affinity than Cd²⁺, enabling effective ion exchange even in competitive environments.^[24] Thermal degradation of calcium alginate initiates via pyrolysis above 200°C, producing a char residue through dehydration and depolymerization.^[25] This process involves the breakdown of polysaccharide chains, yielding volatile products like water, CO₂, and hydrocarbons.^[26] In physiological conditions, calcium alginate displays high biocompatibility, characterized by non-toxicity and minimal immunogenicity, as purified forms elicit negligible immune responses in vivo.^[27] Its lack of adverse interactions with biological systems stems from the inert nature of the crosslinked network.^[28]

Preparation

Extraction of Alginates

Alginate is primarily sourced from brown algae of the class Phaeophyceae, particularly species such as Laminaria, Macrocystis, and Ascophyllum, which are harvested from coastal waters worldwide.^[29] These macroalgae naturally contain alginate as a structural component in their cell walls, making them the dominant raw material for commercial production.^[30] Commercial extraction of alginates began in the late 1920s, with industrial-scale production starting in 1929, initially for applications like boiler additives and food stabilizers.^[29] As of 2023, global production is estimated at approximately 55,000 metric tons per year, reflecting steady growth driven by demand in food, pharmaceutical, and industrial sectors.^[31] The extraction process begins with pretreatment of dried algae, including grinding and washing to remove impurities like salts and proteins. Alkaline extraction follows, typically using a 1–2% sodium carbonate (Na₂CO₃) solution at 40–60°C for 1–2 hours to solubilize the alginate as sodium alginate.^[32] The resulting viscous slurry is then filtered to separate insoluble residues, often with the aid of filter presses or centrifugation.^[33] Precipitation occurs by acidifying the filtrate with hydrochloric acid (HCl) to pH 3, forming insoluble alginic acid, which is collected and purified through washing and neutralization with Na₂CO₃ to yield sodium alginate.^[32] Alginate yields vary significantly, typically ranging from 10–40% of the algae's dry weight, influenced by factors such as algal species, seasonal growth conditions, and harvesting timing. For instance, Sargassum filipendula yields 15.1–17.2% alginate depending on the season, with higher contents often observed in mature plants during cooler months.^[2] Environmental sustainability poses challenges, as wild harvesting can disrupt coastal ecosystems; recent efforts have shifted toward farmed kelp cultivation to mitigate overexploitation and ensure consistent supply.^[29]

Conversion to Calcium Alginate

Calcium alginate is primarily produced in laboratory settings through the ionotropic gelation method, where a solution of soluble alginate salts, such as sodium alginate at concentrations of 1–3% (w/v), is added dropwise to a bath of calcium chloride (CaCl₂) at 0.5–2 M. This process induces rapid ionic crosslinking as calcium ions (Ca²⁺) bind to the guluronate blocks of the alginate chains, forming insoluble, gelatinous spherical beads or fibers. The resulting structures typically range in size from 50 to 5000 μm, depending on the method of addition, with smaller particles achieved through techniques like emulsification or microfluidics.^[2]^[34]^[35] Key parameters influencing the production include the alginate concentration, which affects gel viscosity and crosslinking density; the Ca²⁺ dosage, where higher levels promote faster gelation but may lead to brittle structures; and stirring speed in the CaCl₂ bath, which controls bead uniformity and size by preventing aggregation. For instance, increased stirring reduces particle diameter by enhancing dispersion, while lower alginate concentrations yield more homogeneous gels with improved mechanical strength. This gelation mechanism relies on Ca²⁺ ions bridging adjacent alginate chains, as detailed in the chemical properties section. Alternative routes include direct precipitation of alginic acid with calcium hydroxide (Ca(OH)₂) to form the calcium salt, or dialysis of sodium alginate solutions against calcium-containing media to gradually diffuse ions and form gels without harsh precipitants.^[34]^[36]^[1]^[37] On an industrial scale, continuous production employs extrusion of sodium alginate solution through nozzles or spinnerets into a CaCl₂ bath, enabling high-throughput formation of beads, films, or fibers, followed by washing to remove excess salts and drying at 40–60°C to preserve structure and prevent degradation. This method supports large-scale output, with annual global production exceeding 55,000 metric tons of alginate derivatives as of 2023.^[33]^[31] Purity standards distinguish applications: food-grade calcium alginate (E404) must meet EU regulations with limits such as <3 ppm arsenic and <5 ppm lead, while pharmaceutical-grade requires >90% alginate content and compliance with USP monographs for biocompatibility and low endotoxin levels.^[3]^[38]

Applications

Food and Beverage Industry

Calcium alginate, designated as food additive E404 in the European Union, functions primarily as a gelling agent, thickener, and stabilizer in various food products.^[39] It is commonly incorporated into ice cream to prevent ice crystal formation and improve mouthfeel, into sauces for enhanced viscosity and emulsion stability, and into bakery fillings to maintain texture during processing and storage.^[39] These properties arise from its ability to form gels through ionic crosslinking with calcium ions, creating networks that trap water and other components without requiring heat.^[40] In specific applications, calcium alginate is utilized for the encapsulation of flavors and oils into spherical beads, enabling controlled release during consumption to preserve sensory attributes and extend shelf life.^[41] For instance, essential oils and liquid smoke flavors have been successfully microencapsulated in calcium alginate matrices, protecting them from oxidation and allowing gradual diffusion in products like beverages and processed meats.^[42] Additionally, it serves as a vegan alternative to animal-derived gelatin in desserts, forming clear, firm gels suitable for jellies, pectins, and molecular gastronomy techniques such as spherification.^[43] The U.S. Food and Drug Administration (FDA) recognizes calcium alginate as generally recognized as safe (GRAS) under 21 CFR 184.1187, permitting its use in food at levels consistent with good manufacturing practices. In the European Union, as E404, it is approved at quantum satis (as needed for functionality) in most categories such as dairy desserts, confectionery, and fine bakery wares, with maximum levels of 5000 mg/kg (0.5%) in specific products like chewing gum, ensuring safety and functionality without exceeding acceptable daily intakes.^[39]^[44] Key advantages include the formation of heat-stable gels that withstand temperatures up to 100°C, making it ideal for pasteurized or cooked foods, and shear-thinning behavior in solutions, which facilitates easy pouring and pumping during production.^[40] These characteristics contribute to consistent product quality under varying processing conditions.^[45] As of 2024, recent innovations include its incorporation into plant-based meat analogs, where calcium alginate composite gels with proteins like potato enhance fibrous texture and juiciness, mimicking animal meat structures.^[46] It is also employed in low-calorie, syneresis-free jellies, leveraging its high water-holding capacity to minimize liquid separation and support reduced-sugar formulations.^[47]

Biomedical and Pharmaceutical Uses

Calcium alginate is widely utilized in biomedical applications due to its biocompatibility, gel-forming properties, and ability to interact with biological tissues. In wound care, it serves as a key component in absorbent dressings, such as calcium-sodium alginate fibers or gels like Kaltostat, which conform to the wound bed and manage exudate effectively.^[48]^[49] These dressings maintain a physiologically moist environment that promotes autolytic debridement and epithelialization while minimizing bacterial penetration.^[50]^[51] Additionally, the release of calcium ions (Ca²⁺) from the matrix facilitates hemostasis by activating the coagulation cascade, making it suitable for wounds with minor bleeding.^[48]^[52] The material biodegrades gradually, typically over 7 to 14 days in uncontaminated wounds, allowing for natural absorption without frequent changes.^[53] In pharmaceutical applications, calcium alginate microspheres enable sustained drug delivery, particularly for antibiotics and proteins, by encapsulating active agents within a crosslinked gel network. Encapsulation efficiencies often exceed 80%, as demonstrated with epidermal growth factor (EGF) at 93.8%, ensuring high payload retention during preparation.^[54] Release kinetics are controlled by the diffusion of Ca²⁺ ions, which destabilizes the gel in response to environmental pH changes, such as in the colon for oral delivery systems, providing targeted and prolonged therapeutic effects.^[54] This approach enhances bioavailability compared to free drugs and has been applied to agents like catechin for antimicrobial purposes.^[55]^[56] For tissue engineering, calcium alginate acts as a biocompatible scaffold for cell immobilization, particularly supporting chondrocyte proliferation and extracellular matrix production in cartilage regeneration. Constructs formed by suspending chondrocytes in alginate solutions and crosslinking with CaCl₂ allow for de novo cartilage formation, with viable tissue observed at cell densities as low as 1.0 × 10⁶ cells/mL after 12 weeks in vivo.^[57] The material's mild gelling conditions preserve cell viability, and its mechanical properties mimic native cartilage, facilitating applications in articular repair.^[57]^[58] The first commercial calcium alginate dressings emerged in the early 1980s, marking a milestone in modern wound management by shifting from traditional gauze to advanced biomaterials.^[59] Recent advancements, as of 2024, include antimicrobial-loaded hydrogels incorporating silver nanoparticles or cationic peptides into calcium alginate matrices, enhancing infection control in chronic wounds like diabetic ulcers while promoting faster tissue regeneration.^[60]^[61] Clinical studies, including meta-analyses of randomized controlled trials, demonstrate the efficacy of calcium alginate dressings in chronic wounds, significantly reducing healing time by an average of 11.4 days compared to conventional treatments across 860 patients.^[62] This corresponds to improvements of 20–30% in healing rates for conditions like pressure ulcers and leg ulcers, alongside decreased pain and fewer dressing changes.^[62]

Industrial and Other Applications

Calcium alginate finds extensive use in industrial applications beyond food and biomedical fields, particularly in textile manufacturing where it is processed into fibers via wet-spinning or microfluidic techniques to produce flame-retardant fabrics with high water absorption properties. These fibers, derived from sodium alginate solutions cross-linked with calcium ions, exhibit inherent non-flammability due to the formation of a protective char layer during combustion, making them suitable for protective clothing and upholstery. For instance, blends of calcium alginate with natural fibers like wool or cashmere enhance moisture management and limit of oxygen index (LOI) values up to 40%, reducing smoldering risks compared to untreated cotton.^[63]^[64]^[65] In agriculture, calcium alginate serves as a soil conditioner by forming hydrogel networks that improve water retention in arid soils, thereby enhancing nutrient availability and crop yields. Its biocompatibility and slow-release properties allow it to encapsulate fertilizers or amendments, mitigating rapid nutrient leaching and supporting sustainable farming practices. Additionally, calcium alginate is employed in seed coatings, where seeds are encapsulated in alginate matrices cross-linked with calcium chloride to control germination rates, protect against environmental stressors, and promote uniform emergence in crops like wheat and vegetables. This encapsulation technique, involving immersion in sodium alginate followed by calcium gelation, has demonstrated improved seedling vigor and reduced seed loss during handling.^[66]^[67]^[68] A key industrial application of calcium alginate is in water treatment as a biosorbent for heavy metal removal, leveraging its chelation properties to bind ions like Cu²⁺ through ion-exchange and complexation mechanisms. Studies have shown that calcium alginate beads achieve up to 90% adsorption efficiency for Cu²⁺ at pH 5, with capacities exceeding 100 mg/g under optimized conditions, making it effective for treating industrial effluents from mining and electroplating. The beads can be regenerated using dilute acid washes, such as 0.1 M HCl, restoring over 80% of their adsorption capacity for multiple cycles without significant degradation.^[69]^[70]^[71] In cosmetics, calcium alginate acts as a natural thickener and stabilizer, providing viscosity control in formulations like creams and gels due to its gel-forming ability upon hydration. Its mild, non-irritating nature supports use in skincare products for texture enhancement and moisture retention. Emerging applications include porous calcium alginate structures in solar evaporators for desalination, where 2025 advancements in hydrogel designs have achieved evaporation efficiencies over 90% under 1 kW/m² solar irradiation by reducing water's latent heat through capillary action and photothermal effects. These evaporators, often incorporating centrosymmetric geometries, enable high-rate seawater purification while resisting salt fouling.^[6]^[72]^[73] The global calcium alginate market is experiencing robust growth, projected to reach approximately $404 million by 2030, driven by demand in textiles, water remediation, and emerging sustainable technologies.^[74]

Safety and Environmental Considerations

Toxicity and Regulatory Status

Calcium alginate exhibits low acute toxicity, with an oral LD50 estimated to exceed 5,000 mg/kg in rats based on assessments of the compound and related alginate formulations.^[75] It is also non-irritant to skin and eyes, consistent with standard evaluations for alginates under guidelines similar to OECD protocols for irritation testing.^[76] Allergic reactions to calcium alginate are rare but have been reported, attributed to sensitivity to alginate derived from brown algae.^[77] Regulatory approval for calcium alginate is widespread, including designation as generally recognized as safe (GRAS) by the U.S. Food and Drug Administration under 21 CFR 184.1187 for use as a stabilizer and thickener in food.^[78] In the European Union, it is authorized as food additive E404 without a numerical acceptable daily intake, indicating no safety concern at typical use levels.^[39]^[79] It is also included in the United States Pharmacopeia (USP) and European Pharmacopoeia (EP) monographs for alginic acid salts, permitting its use in pharmaceutical and medical device applications such as wound dressings. No specific permissible exposure limit (PEL) has been established by the Occupational Safety and Health Administration (OSHA) for calcium alginate; however, as a nuisance dust, general limits apply at 15 mg/m³ for total dust and 5 mg/m³ for the respirable fraction over an 8-hour time-weighted average.^[80] Long-term studies on alginates, including calcium variants, show no evidence of carcinogenicity, and the compound is not classified by the International Agency for Research on Cancer (IARC) due to insufficient data for evaluation (Group 3).^[81] It is considered safe for oral and topical use, with no adverse effects reported at typical exposure levels in food and pharmaceutical contexts.^[39] This aligns with its biocompatibility in gel forms for biomedical applications.^[82]

Biodegradability and Environmental Impact

Calcium alginate exhibits high biodegradability due to its natural polysaccharide structure derived from brown algae, which is susceptible to enzymatic breakdown by environmental microorganisms. Calcium alginate is highly biodegradable in both soil and marine environments through enzymatic degradation by bacteria such as Pseudomonas, Pseudoalteromonas, and Vibrio species, which produce alginate lyases to break down the polymer into simpler compounds, leading to mineralization. Degradation rates depend on environmental conditions like temperature, pH, and microbial activity.^[83]^[84] These processes result in mineralization to carbon dioxide, water, and biomass.^[85] The life cycle of calcium alginate begins with renewable sourcing from macroalgae, which sequester CO₂ through photosynthesis at high rates, potentially up to 50-60 tonnes per hectare annually in productive cultivation systems, contributing to carbon mitigation during production.^[86] However, unsustainable harvesting practices can disrupt marine habitats, leading to reduced biodiversity in kelp forests that serve as critical ecosystems for fish and invertebrates, with experimental studies showing increased herbivory and slower recovery in overharvested subtidal areas.^[87] To address this, sustainable cultivation methods, such as integrated multi-trophic aquaculture, are recommended to minimize ecological impacts while maintaining supply.^[88] In waste management, calcium alginate is compostable under industrial conditions, achieving significant breakdown in over three months, making it suitable for organic waste streams without persistent residues.^[83] Recent studies from 2024 highlight its role as a microplastic-free alternative to synthetic gels in applications like seed coatings and food packaging, where it degrades naturally without contributing to marine pollution, unlike petroleum-based polymers that persist for centuries.^[89] Environmentally, calcium alginate offers benefits over synthetic polymers by reducing eutrophication risks, as its algal-derived nature avoids the nutrient leaching associated with petrochemical production and supports soil enrichment upon degradation.^[90] Its carbon footprint is relatively low, estimated at 0.3-1.37 kg CO₂eq per kg in optimized production scenarios using bioenergy integration, compared to 2-4 kg CO₂eq per kg for conventional plastics like PET.^[91] Recent studies as of 2025 have explored alginate-based materials for phosphate adsorption in wastewater treatment, further emphasizing their environmental benefits.^[92] Challenges include overharvesting of wild algae stocks, which has prompted regulatory responses such as the EU's Farm to Fork Strategy since 2020, mandating sustainable sourcing to prevent habitat degradation and ensure traceability in hydrocolloid supply chains.^[93] Industry codes of conduct further enforce limits on extraction rates to promote long-term ecological balance.^[94]

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Aug 5, 2014 · Viscous solutions of alginate exhibit shear-thinning properties caused by parallel arrangement of the linear molecule chains. Alginate ...
[45]
Innovative method for producing plant-based meat analogs: Acid ...
In this study, we investigated the potential of using potato protein/calcium alginate composite gels to formulate plant-based meat analogs.
[46]
Current Review: Alginate in the Food Applications - MDPI
Aug 5, 2024 · Alginate has three different types of blocks: G, M, and MG. The average pKa value of alginate is 3.5, which explains that as the pH value ...<|control11|><|separator|>
[47]
Kaltostat Calcium-Sodium Alginate Wound Dressings - Medline
Dressing provides a moist environment, helping to create optimal wound healing conditions ... Also designed to promote hemostasis, providing a matrix to ...
[48]
KALTOSTAT® Calcium Sodium Alginate Dressing - Wound - Convatec
KALTOSTAT ® Calcium Sodium Alginate dressing is indicated for moderately to highly exuding chronic and acute wounds, and for wounds with minor bleeding.Missing: properties hemostasis moist environment
[49]
Alginate in Wound Dressings - PMC - NIH
They enhance wound healing process, permeability to water vapor, carbon dioxide and oxygen, protect the wound from bacterial infections, and their mechanical ...Missing: definition | Show results with:definition<|control11|><|separator|>
[50]
Alginate Dressing - an overview | ScienceDirect Topics
Thus, alginate dressings may help to maintain a moist microenvironment conducive to healing, whilst limiting wound secretions and minimising bacterial ...
[51]
[PDF] Alginates as haemostatic agents: worth revisiting? - Wounds UK
Alginate dressings are now well- established, being used for their conformability, absorbency and ability to provide a moist wound healing environment (Thomas, ...
[52]
Alginate Dressings Continuously for 14 Days on Uncontaminated ...
Jul 5, 2023 · Calcium alginate dressings are commonly used on split-thickness skin donor sites, where they are typically removed after 14 days.
[53]
Oral alginate microspheres for the efficient site-specific delivery of ...
Aug 15, 2024 · The encapsulation efficiency of EGF was reaching to 93.8 % ± 1.6 %. In vitro release experiments showed that MS-EGF presented the good pH ...
[54]
Calcium-alginate microparticles for sustained release of catechin ...
Oct 31, 2016 · These results suggest that catechin encapsulation within Ca-alginate particles by emulsion gelation method can be an effective delivery system ...<|separator|>
[55]
Current Status of Alginate in Drug Delivery - Hariyadi - 2020
Aug 6, 2020 · Several studies showed that the bioavailability of drugs encapsulated in alginate hydrogels is greater than that of the free drug applied ...Abstract · Introduction · Application of Alginates in... · Various Techniques to...
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De Novo Cartilage Generation Using Calcium Alginate-Chondrocyte ...
These studies investigated the utility of calcium alginate as a biocompatible polymer matrix within which large numbers of chondrocytes could be held ...
[57]
Calcium/Cobalt Alginate Beads as Functional Scaffolds for Cartilage ...
The field of tissue engineering currently offers some of the most promising strategies for cartilage restoration, in which assorted biomaterials and cell-based ...
[58]
Alginate Dressings: Part 1: Historical Aspects - ScienceDirect
The birth of the modem use of alginates occurred in the early 1980s which quickly led to the production of various products. Their common characteristics and ...
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Antibacterial Hydrogels for Wound Dressing Applications - MDPI
Jul 26, 2024 · The hydrogels with a lower HS loading amount (0.5 and 1 mg/mL) exhibited an excellent biocompatibility (more than 96% after 72 h). Therefore, it ...
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Alginate Dressings in Wound Care: A Systematic Review and Meta-An
The results of this study suggest that the use of alginate dressings may shorten wound healing time, relieve wound pain, and reduce the number of dressing ...
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Fabrication, Property and Application of Calcium Alginate Fiber - NIH
Aug 8, 2022 · Calcium alginate fiber as a common alginate-based material exhibited excellent intrinsic flame retardant properties due to the presence of ...
[63]
Flame retardancy and combustion performance of polysaccharide ...
Calcium alginate fabric has no after-flame, longer smoldering, and lower fire hazards than cotton, producing a protective char barrier.
[64]
Cashmere Blended with Calcium Alginate Fibers: Eco-Friendly ...
Blending cashmere with calcium alginate fibers improves flame retardancy and maintains hygroscopicity, reaching a LOI of 40.2 without smoldering.
[65]
Alginate-based composites as novel soil conditioners for ... - NIH
The application of alginate-based composites can efficaciously alleviate the rapid release of urea or nutrients and improve soil water-holding capacity. It can ...
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Alginate-based composites as novel soil conditioners for ...
Dec 15, 2023 · This paper systematically reviews the current literature on the preparation, characterization, and agricultural applications of various alginate-based ...
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(PDF) Seeds encapsulation in calcium alginate pellets - ResearchGate
Aug 10, 2025 · Seeds of wheat, cabbage, basil and radish were successfully encapsulated in calcium alginate according to a protocol allowing the gelation of the polymer from ...
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Effective removal of Cu2+ ions from aqueous medium using alginate ...
This study indicates that calcium alginate beads could be used as an efficient biosorbing material for the treatment of high Cu 2+ bearing water streams.
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Copper adsorption on calcium alginate beads: Equilibrium pH ...
Aug 6, 2025 · In the present work, a study of adsorption of copper(II) ions onto calcium alginate beads has been carried out.
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The Fabrication of Calcium Alginate Beads as a Green Sorbent for ...
May 17, 2019 · The adsorption experiments demonstrated that the CA beads exhibited a high removal efficiency for the selective adsorption of Cu(II) from the ...
[71]
The Role of Calcium Alginate in Cosmetic Formulations
Its natural thickening and gelling properties, similar to its uses of calcium alginate in food, allow formulators to achieve desired viscosities and textures in ...
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Preparation of Calcium Alginate-Based Hydrogels with Precisely ...
Jan 15, 2025 · Hydrogels are popular materials for desalination and can significantly reduce the vaporization enthalpy of water; however, there are few ...
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Calcium Alginate Market worth $403.58 million by 2030, growing
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[PDF] Safety Data Sheet SECTION 1 - 3M
Alginic acid, calcium salt. 9005-35-0 ... LD50 estimated to be > 5,000 mg/kg. Sodium alginate. Ingestion. Rat. LD50 > 5,000 mg/kg. ATE = acute toxicity estimate.<|separator|>
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[PDF] Safety Data Sheet (SDS) - KIMICA Corporation
Sep 21, 2004 · Acute toxicity-oral. Not classified. Acute toxicity-dermal. Classification not possible. Skin corrosion/irritation. Classification not possible.
[76]
(PDF) Anaphylaxis caused by alginate dressing - ResearchGate
A study published in Contact Dermatitis suggests that alginates may trigger an allergic reaction in some individuals (McCarthy et al., 2018) .
[77]
21 CFR 184.1187 -- Calcium alginate. - eCFR
Calcium alginate (CAS Reg. No. 9005-35-0) is the calcium salt of alginic acid, a natural polyuronide constituent of certain brown algae.
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E 404 Calcium alginate - EU specification - CyberColloids
E 404 Calcium alginate – EU specification. COMMISSION REGULATION (EU) No 231/2012 of 9 March 2012. Synonyms. Calcium salt of alginate.
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Agents Classified by the IARC Monographs, Volumes 1–139
Jun 27, 2025 · Agents Classified by the IARC Monographs, Volumes 1–139. Group 1, Carcinogenic to humans, 135 agents. Group 2A, Probably carcinogenic to humans ...List of Classifications · Preamble · PublicationsMissing: calcium alginate long-<|control11|><|separator|>
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Alginate: Current Use and Future Perspectives in Pharmaceutical ...
Dec 28, 2016 · The focus of the paper is to describe biological and pharmacological activity of alginates and to discuss the present use and future possibilities of alginates.
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Marine-derived biopolymers as potential bioplastics, an eco-friendly ...
Apr 21, 2023 · Industrial compostability within more than 3 months and in seawater within 1-6 months at 30 °C. ... Degrade within 4-6 weeks in a soil environment ...
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Degradation and Utilization of Alginate by Marine Pseudoalteromonas
Alginate is degraded by alginate lyases, which are synthesized by marine algae (9), marine mollusks (10), and a wide range of microorganisms, including marine ...
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A review of biodegradation and formation of biodegradable ...
Dec 21, 2024 · At pH 7 in well water, PHB exhibited the highest degradation rate of 92.8% within six weeks [110]. The degradation of alginate is pH-dependent, ...
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[PDF] mCDR and carbon sequestration in various macroalgae products
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Effects of harvesting on subtidal kelp forests (Lessonia trabeculata ...
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Integrated techno-economic and life cycle assessment of a novel ...
This study evaluates a novel biomimetic coating primarily consisting of a hydrogel seeded with microalgae biomass printed on a polyethylene substrate.Missing: habitat disruption
[88]
Transitioning to Microplastic-Free Seed Coatings - PubMed Central
This review addresses the issue of replacing manufactured microplastics in seed coatings used in agriculture.
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Macroalgal-Derived Alginate Soil Amendments for Water Retention ...
Aug 29, 2022 · Alginate is a natural carbohydrate that can be used to produce biodegradable hydrogels, and in contrast to synthetic polymers, enriches the soil ...
[90]
The environmental impact and economic feasibility assessment of ...
Jun 12, 2023 · This study presents a new process on the production of biodegradable calcium alginate (Ca(Alg) 2 ) composite bioplastic, and evaluates its economic feasibility ...
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Towards a Strong and Sustainable EU Algae Sector - EUR-Lex
Nov 15, 2022 · The EU aims to harness algae as a renewable resource, contribute to the Green Deal, and develop a strong, sustainable sector for food, feed, ...Missing: alginate overharvesting
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Entering the European market for seaweed hydrocolloids - CBI
Dec 7, 2023 · As an exporter of seaweed hydrocolloids from a developing country, you must ensure the safety of your products for use in the European market.