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EEE

Eastern equine encephalitis (EEE) is a rare, mosquito-transmitted viral infection caused by the (EEEV), a single-stranded in the family Togaviridae. Primarily endemic to the eastern and Gulf Coast regions of the , as well as parts of and the , EEEV maintains an enzootic cycle between avian reservoir hosts such as birds and bridge vectors like Culiseta melanura mosquitoes. Humans and equines acquire the virus incidentally through bites from infected mosquitoes but typically produce insufficient to sustain transmission, rendering them dead-end hosts. Most human infections with EEEV are subclinical or result in mild, nonspecific febrile illness resembling a flu-like , but progression to neuroinvasive occurs in a subset of cases, manifesting as acute with rapid onset of headache, high fever, vomiting, and altered mental status. Severe EEE carries a case-fatality rate of approximately 30%, with death often ensuing within days of symptom onset due to , seizures, and multi-organ failure; among survivors, over half experience lasting neurological sequelae including cognitive deficits, , and . The disproportionately affects young children and older adults, underscoring vulnerabilities in immune response and neurodevelopmental stages. EEE's public health significance stems from its sporadic but explosive epizootics, often linked to environmental factors like habitats and late-summer peaks, as evidenced by multistate outbreaks in the U.S. such as the 2019 event involving cases in , , and other states. Equine cases serve as sentinels for human risk, with vaccination available for horses but no licensed human , relying instead on integrated surveillance, larval habitat elimination, and personal protective measures like repellents and netting for prevention. Diagnostic confirmation involves , , or viral culture from , emphasizing the need for early intervention with supportive care, as no specific antiviral therapy exists. Despite its low incidence—fewer than 10 human cases annually on average in the U.S.—EEE exemplifies the persistent threat of arboviral pathogens in a changing , where altered dynamics may expand foci.

Computing and Technology

Energy-Efficient Ethernet

(EEE) refers to enhancements in the Ethernet standard that reduce power consumption in network interfaces during periods of low or no data transmission. The core mechanism, known as Low Power Idle (LPI) mode, allows transceivers to enter a dormant state by signaling conditions to linked devices, thereby minimizing use in components such as serializers/deserializers and analog front-ends. This applies primarily to twisted-pair Ethernet variants including 100BASE-TX, 1000BASE-T, and 10GBASE-T, where continuous signaling of patterns in traditional Ethernet wastes significant power. The IEEE 802.3az amendment, ratified on October 7, 2010, as an update to IEEE Std 802.3-2008, formalized these changes after deliberations starting around 2006 to address escalating energy demands in networked systems. Prior proprietary implementations, such as those in early "Green Ethernet" switches, demonstrated feasibility but lacked until the standard's completion. LPI mode operates by refreshing the link periodically—typically every few microseconds—to maintain , with wake-up times under 50 microseconds for gigabit links to limit impacts. Power savings stem from eliminating steady-state idle power draw, which can constitute 50-90% of a link's total consumption depending on utilization rates below 10%. For 1000BASE-T interfaces, EEE can reduce PHY-layer power by over 1 watt per port during idle, scaling to substantial reductions in multi-port switches; system-wide savings in underutilized networks exceed 40% in some deployments. These gains arise causally from deactivating high-power analog circuits without altering data transmission protocols, though full benefits require compatibility and auto-negotiation support. Adoption has grown in enterprise and equipment from vendors like and , where EEE is configurable via management interfaces, but it is often disabled in latency-sensitive environments like due to wake-up delays. Empirical measurements confirm minimal performance degradation for typical traffic patterns, with energy proportionality improving as link speeds increase, aligning EEE with broader efficiency trends in Ethernet evolution. Overall, EEE contributes to reducing the of IP networks, which consumed approximately 18 TWh in the U.S. alone by 2008, by targeting idle inefficiencies without compromising capacity.

Asus Eee PC

The was a line of subcompact laptops introduced by AsusTek Computer Inc. in late , designed to provide affordable, portable for tasks such as web browsing, email, and light productivity. The original model, the Eee PC 701, launched on October 16, , featuring a 7-inch display, an underclocked M processor at 570 MHz, 512 MB of RAM, a 4 GB solid-state drive (SSD), and a custom Linux-based operating system optimized for low resource use. Priced under $400, it emphasized durability, instant-on boot times, and energy efficiency over high performance, targeting students and emerging markets. The Eee PC rapidly popularized the netbook category, with Asus selling approximately 350,000 units in its initial months and reaching 4.9 million units by the end of 2008, capturing around 46% of the early netbook market share. This surge prompted competitors like Acer and Hewlett-Packard to enter the segment, driving netbook shipments to under 1 million units in the sector's first year but fostering broader adoption of low-cost portable devices. Success stemmed from its balance of portability—weighing about 0.99 kg—and simplicity, though limitations like the small screen and keyboard drew criticism for usability in extended sessions. Subsequent models evolved to address these constraints, expanding to the 700 series variants with minor tweaks, then the 900 series in 2008 introducing a 8.9-inch screen, up to 16 GB SSD, and optional support, while later iterations like the 1000 series adopted processors, 10-inch displays, and up to 250 GB hard drives for improved multimedia capabilities. By 2010, the lineup included touch-enabled options and higher-resolution variants, but sales declined amid competition from smartphones, tablets, and ultrabooks offering better performance and battery life. discontinued the Eee PC series in 2012, citing shifting consumer preferences toward touch-centric devices.

Embrace, Extend, and Extinguish

"Embrace, extend, and extinguish" (EEE) describes a competitive strategy attributed to during the 1990s and early 2000s, whereby the company would adopt (embrace) emerging open standards or technologies, implement proprietary extensions to those standards, and ultimately leverage its dominant market position to marginalize or eliminate competing implementations, thereby reinforcing its ecosystem lock-in. The phrase gained prominence in the United States v. antitrust litigation (1998–2001), where the U.S. Department of Justice (DOJ) cited internal communications outlining a plan to counter the browser threat by embracing standards, extending them with Microsoft-specific features in , and extinguishing Netscape's market share through integration with Windows. This approach was not formalized as official company policy but reflected documented internal strategies to defend Windows monopoly power against cross-platform threats. A key example involved the Java programming language, licensed by Microsoft from Sun Microsystems in 1996 under terms requiring platform-neutral implementations. Microsoft embraced Java by integrating support into its developer tools and browsers but extended it with proprietary Windows-only features via Visual J++, such as modified virtual machines and APIs that optimized for Internet Explorer and tied applications to the Windows platform, violating the license agreement. This extension aimed to undermine Java's cross-platform promise, as evidenced by internal Microsoft documents acknowledging the goal of fragmenting Java to favor Windows-specific development; Sun sued Microsoft in October 1997, resulting in a 2001 settlement where Microsoft agreed to remove the extensions and pay royalties, though Java's momentum toward Windows dependency had already been disrupted. Another instance concerned the authentication protocol, an for secure network access originally developed at . Microsoft embraced Kerberos by incorporating it into for domain services but extended it with non-interoperable elements, including custom encryption types (e.g., RC4-HMAC) and realm trust mechanisms that required Microsoft-specific configurations, rendering third-party implementations incompatible without significant rework. These extensions, introduced around 1999–2000, effectively locked enterprise customers into Microsoft's ecosystem, as non-Microsoft Kerberos systems struggled with interoperability; critics, including protocol experts, argued this exemplified EEE by initially supporting the standard to gain adoption, then diverging to extinguish open alternatives. Microsoft consistently denied that EEE constituted a deliberate anti-competitive , asserting that extensions represented legitimate to meet customer needs, such as enhanced or tailored to Windows users, rather than predatory intent. However, the DOJ's case, supported by leaked "" from 1998—internal memos analyzing open-source threats like —revealed discussions of "embracing and extending" standards to co-opt competitors, contributing to the court's 2000 finding that Microsoft maintained a through exclusionary conduct. The strategy's outcomes included temporary dominance in browsers ( peaked at over 90% by 2003) and enterprise protocols but faced backlash, including the 2001 antitrust settlement mandating disclosures and browser unbundling, which facilitated later competition from and . Empirical analysis of Microsoft's responses to 12 standards from 1990–2005 shows a pattern of partial compatibility that favored lock-in over full .

Engineering and Academia

Electrical and Electronics Engineering

Electrical and electronics engineering encompasses the study, design, and application of systems that harness , , and components to enable technologies ranging from power grids to microchips. This discipline integrates principles of physics, , and to develop devices and infrastructure that generate, transmit, distribute, and control , as well as through circuits. Practitioners address challenges in , reliability, and , ensuring systems meet standards while minimizing environmental . The field traces its origins to the 19th century, spurred by breakthroughs in and practical inventions. Michael Faraday's 1831 discovery of laid foundational groundwork for electric generators and motors, while the 1882 opening of Thomas Edison's marked the first commercial direct-current power plant, serving 59 customers in . Formal education emerged soon after, with the world's first dedicated program established in 1883 at in . By the early , electronics engineering distinguished itself as a subfield, focusing on vacuum tubes and early semiconductors, evolving from electrical engineering's emphasis on macro-scale power systems. Electrical primarily deals with high-power applications such as , , and of , often involving voltages in the kilovolt range for grids and . In contrast, centers on low-power, signal-based systems, including integrated circuits, semiconductors, and digital logic for devices like smartphones and sensors, where flow at micro- and nano-scales predominates. Despite overlap—many programs combine both under a unified —the distinction influences paths: optimize large infrastructure like farms, while innovate in embedded systems and consumer gadgets. Subfields span power systems, , , , and , with professionals employing tools like circuit simulation software and finite element analysis for design validation. In the , key advancements include the proliferation of renewable integration via smart grids, which use sensors and for real-time load balancing and efficiency gains exceeding 20% in some implementations; the rise of electric vehicles, demanding high-density batteries and for rapid charging; and (IoT) ecosystems, connecting billions of devices through low-power wireless protocols. Developments in semiconductors, such as transistors, have enabled higher efficiency in power converters, reducing energy losses by up to 50% compared to silicon counterparts. These innovations address global demands for , with electrical and electronics engineers contributing to net-zero goals through optimized systems that minimize waste and enhance resilience against disruptions.

Earth and Environmental Engineering

Earth and Environmental Engineering is an interdisciplinary discipline that applies engineering methodologies to earth's physical systems and environmental challenges, integrating principles from , , , , and to manage natural resources and mitigate human impacts. This field emphasizes quantitative analysis of processes such as constituent and in natural media, alongside sustainable resource extraction and pollution remediation. Unlike narrower subfields, it incorporates earth sciences to address geospheric interactions, including subsurface flows and . The discipline traces its origins to mid-19th-century and education, with the first U.S. program established in 1864 at what became University's School of Mines, founded by Thomas Egleston to train professionals in resource extraction. Broader environmental engineering roots emerged in the 1830s through for and in expanding urban areas. By the late 1990s, programs evolved to prioritize environmental integration, as seen in 's 1996 MS in Earth Resources Engineering and 1998 ABET-accredited BS in Earth and , reflecting a shift toward amid growing concerns over and . Core methodologies involve modeling physical, chemical, and biological processes in environmental systems, such as via pump-and-treat techniques or carbon capture through adsorption and geochemical reactions. Key topics include systems, where engineers design storage solutions like advanced batteries to support renewables; water resource management, focusing on treatment and distribution to ensure potable supplies; and waste handling, encompassing solid, hazardous, and mining tailings to prevent ecosystem contamination. Climate-resilient infrastructure design addresses flood risks and through geotechnical modeling, while sustainable mining applies beneficiation to minimize land disturbance. In industry, practitioners develop processes for pollution control in sectors like energy production, where they optimize to reduce emissions by up to 95% in coal plants, and in , where they implement zero-liquid discharge systems to recycle wastewater. Policy applications include advising on regulations for groundwater protection and remediation, such as permeable reactive barriers that degrade contaminants , and contributing to mitigation strategies in high-emission industries like . Educational programs, typically offering , , and degrees, train students in these areas through coursework in , , and , preparing graduates for roles in consulting firms, agencies, and institutions. Employment in the field supports by engineering solutions to waste disposal and air quality issues, with projected growth driven by regulatory demands for .

Medicine and Biology

Eastern Equine Encephalitis

Eastern equine encephalitis (EEE) is a rare, mosquito-borne viral infection caused by the Eastern equine encephalitis (EEEV), an in the family Togaviridae. The primarily circulates in wild reservoirs and is transmitted to s and equines via the bite of infected mosquitoes, particularly like and Culiseta in endemic areas such as freshwater hardwood swamps along the Atlantic and Gulf Coasts of the . Human infections are incidental, with most cases or mild, but neuroinvasive disease occurs in approximately 5% of infections, leading to severe . Transmission is seasonal, peaking from July to October in northern regions and earlier in southern states, with rare non-mosquito routes documented, including from infected donors. Clinically, EEE progresses rapidly in severe cases, with an of 4–10 days followed by systemic symptoms such as fever, , and . Neuroinvasive manifestations include meningismus, altered mental status, focal neurologic deficits, seizures, and , often requiring intensive care. The case-fatality rate for neuroinvasive EEE exceeds 30%, reaching up to 75% in some reports, with approximately 50% of survivors experiencing permanent neurologic sequelae such as , , or . Diagnosis relies on clinical presentation combined with laboratory confirmation via (RT-PCR) or (IgM) antibodies in or serum, as imaging may show nonspecific brain or thalamic involvement. Epidemiologically, the United States reports 4–8 human cases annually on average, though outbreaks vary; for instance, experienced 12 cases with six deaths in 2019, and multiple states reported cases in 2024. Incidence is higher among individuals over 50 years and those engaging in outdoor activities in endemic foci, with no licensed human vaccine available. Equine cases, which often precede human outbreaks, have fatality rates near 100% without vaccination. No specific antiviral treatment exists; management is supportive, including , anticonvulsants, and corticosteroids in select cases, though evidence for the latter is limited. Prevention emphasizes avoidance: applying EPA-registered repellents containing , wearing protective clothing, and eliminating standing water. Community-level surveillance and larviciding are critical in high-risk areas, while annual protects horses but not humans.

EEE (psychedelic)

EEE, chemically known as 2,4,5-triethoxyamphetamine, is a synthetic classified within the family of substituted . Its molecular formula is C15H25NO3, with a structure featuring ethoxy groups at the 2, 4, and 5 positions of the ring attached to an alpha-methylphenethylamine backbone. This makes it a direct ethoxy analog of 2,4,5-trimethoxyamphetamine (TMA-2), where the methoxy substituents are replaced by longer ethoxy chains, potentially altering receptor binding due to increased steric bulk. The compound was synthesized by chemist as part of his exploration of psychedelic phenethylamines, though specific synthesis details for EEE are not extensively documented in primary literature beyond general derivatization methods involving nitropropene reduction or Leuckart reactions adapted for alkoxy-substituted anilines. Shulgin included EEE in his catalog of compounds in (Phenethylamines I Have Known and Loved), published in 1991, but reported no human trials or dosage information, noting it elicited few to no psychoactive effects. This lack of empirical data on potency, duration, or subjective experiences distinguishes EEE from more studied TMA analogs like TMA-2, which exhibits potent hallucinogenic activity at doses around 20 mg via agonism at serotonin 5-HT2A receptors. Pharmacological profiles for EEE remain largely uncharacterized, with no peer-reviewed studies on its affinities, , or available as of 2025. By structural to TMA-2, it may interact weakly with systems, but the bulkier ethoxy groups likely reduce efficacy compared to methoxy counterparts, consistent with Shulgin's observation of inactivity. derivatives generally undergo hepatic via enzymes, yielding hydroxylated and demethylated (or deethylated) metabolites, but specific pathways for EEE are undocumented. Due to its obscurity and absence of reported recreational or therapeutic use, EEE has not been implicated in clinical trials or overdose cases. In jurisdictions like the , it falls under the as a positional of Schedule I amphetamines, rendering possession or distribution prosecutable if intended for human consumption. No patents or commercial syntheses exist, underscoring its status as a research rather than a viable psychoactive agent.

and

Electronic and Electrical Equipment

Electrical and electronic equipment (EEE) encompasses devices and appliances that rely on electric currents or electromagnetic fields for operation, including household appliances, hardware, lighting, and industrial tools. This sector spans , , and servicing, with products classified into six categories under the Union's Waste Electrical and Electronic Equipment (WEEE) Directive: temperature exchange equipment (e.g., refrigerators), displays and monitors with screens greater than 100 cm², lamps, large equipment exceeding 50 cm in any dimension (e.g., washing machines), small equipment under 50 cm (e.g., toasters), and small IT or lighting equipment (e.g., smartphones, LED bulbs). From a perspective, the global electrical equipment —encompassing core EEE components like transformers, motors, and wiring—was valued at USD 1,513.22 billion in 2024, projected to expand to USD 1,660.20 billion in 2025 amid rising demand for in , electric vehicles, and smart infrastructure. Growth drivers include technological advancements in semiconductors and , with the broader electrical and sector reaching USD 3,844.55 billion in 2024, fueled by consumer demand for connected devices. Major producers face pressures from scarcity, such as rare earth elements, while intensifies in regions dominating output. Environmentally, EEE production and end-of-life disposal generate significant e-waste, estimated to contain hazardous materials like lead, mercury, cadmium, and brominated flame retardants, which leach into soil, water, and air when improperly managed, contributing to pollution and health risks including neurological damage and respiratory issues. In 2022, global e-waste from EEE exceeded 62 million metric tons, with only 22.3% formally recycled, leading to resource losses equivalent to USD 62 billion in metals like gold and copper, alongside greenhouse gas emissions from manufacturing processes reliant on energy-intensive mining and refining. Informal recycling in developing regions exacerbates impacts through open burning and acid leaching, releasing toxins such as dioxins. Regulatory frameworks address these challenges, with the EU's WEEE Directive (2012/19/) mandating producer responsibility for collection, treatment, and recovery targets—such as 85% collection rates for certain categories by 2021—while promoting design for disassembly to minimize environmental harm. Complementing this, the Directive (2011/65/) restricts hazardous substances in EEE to levels below 0.1% for most (e.g., lead, mercury), aiming to facilitate safer and reduce toxicity in waste streams, with exemptions reviewed periodically for essential uses. Compliance burdens businesses with labeling, reporting, and financing obligations, yet evidence indicates these measures have increased EU rates to 42.5% in 2020, though global enforcement gaps persist due to transboundary waste shipments.

Earthquake Environmental Effects

Earthquake environmental effects (EEEs) encompass a range of geological, hydrological, and ecological alterations triggered by seismic shaking, distinct from direct structural damage to human infrastructure. These effects arise from the dynamic stresses imposed on the and surface, leading to phenomena such as , , and fluid mobilization, which can persist long after the primary shaking ceases. Empirical observations from events like the demonstrate how EEEs reshape landscapes, with cascading impacts on soil stability, water systems, and biotic communities. Primary EEEs include earthquake-induced landslides, which occur when shaking exceeds thresholds, mobilizing vast sediment volumes—up to tens of thousands per event on steep terrains—and blocking rivers to form temporary dams. In the 1964 Great Alaska earthquake (magnitude 9.2), landslides contributed to widespread erosion and habitat disruption, altering regional by damaging vegetation and soil structures. Long-term, these failures accelerate hillslope erosion preferentially at lower elevations due to pore pressure dynamics, hindering forest regrowth and exacerbating downstream for decades. Soil liquefaction represents another critical EEE, where cyclic loading during shaking increases in saturated, cohesionless soils, reducing and causing temporary fluid-like behavior. This phenomenon, observed in the 1964 Niigata earthquake, leads to ground subsidence, lateral spreading, and secondary landslides, inverting soil profiles and releasing trapped that degrade and vegetation rooting zones. Ecologically, liquefaction disrupts aquifers and wetlands, with effects extending to microbial communities and habitats through . Tsunamis generated by undersea earthquakes amplify coastal EEEs, inundating shorelines with high-velocity waves that erode sediments, uproot mangroves and forests, and introduce saltwater into freshwater ecosystems. The 2004 tsunami (triggered by a magnitude 9.1 Sumatra-Andaman event) caused extensive vegetation loss, damage, and soil salinization across 14 countries, with inland penetration up to several kilometers fostering long-term declines in affected biomes. Similarly, the 2011 Tōhoku tsunami in devastated marine benthic communities through uplift-induced mortality of and , alongside persisting in coastal sediments. Hydrological disruptions, particularly to , involve oscillatory fluctuations and permanent level offsets from poroelastic responses to seismic stress, as documented by USGS monitoring following the . These changes can render wells turbid by dislodging or alter chemistry via dissolution, indirectly stressing riparian ecosystems through reduced or contamination. In extreme cases, such as the 1964 event, new springs emerged while others dried, reshaping local and favoring over native dependent on stable water tables. Air quality effects, including dust clouds and hazardous releases from disturbed sites, further compound ecosystem stress, as seen in the 2023 earthquakes where particulate emissions elevated levels. Overall, EEEs exhibit scaling with and local , with larger events (e.g., >M7) producing outsized environmental legacies through compounded hazards like cascading landslides and hydrological shifts. Mitigation relies on site-specific assessments of , informed by empirical models rather than generalized assumptions, to preserve resilience.

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