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Chamomile

Chamomile refers to several species of flowering plants in the Asteraceae family, primarily the annual German chamomile (Matricaria recutita, syn. Matricaria chamomilla) and the perennial Roman chamomile (Chamaemelum nobile).^[1]^[2] German chamomile is an erect, heavily branched herbaceous annual native to southern and eastern Europe, western Asia, and northern Africa, typically growing 10–80 cm tall with thin, spindle-shaped roots, bi- to tripinnate feathery leaves, and solitary terminal flower heads 10–30 mm wide featuring white ray florets surrounding a hollow, dome-shaped yellow disc of tubular florets.^[2]^[3] Roman chamomile, in contrast, is a low-growing perennial forb/herb native to western Europe and naturalized in parts of North America, reaching 10–30 cm in height with finely divided, aromatic leaves and daisy-like flowers of white petals around yellow centers, blooming from June to August in dry fields, lawns, and roadsides.^[4] Both species have been valued for millennia in traditional medicine and herbal practices, with records of their use dating back to ancient Egypt, Greece, Rome, and China for treating ailments such as digestive issues, inflammation, and insomnia.^[1]^[5] German chamomile, in particular, was one of the nine sacred herbs among the Anglo-Saxons and has been included in the pharmacopoeias of 26 countries, while Roman chamomile was similarly employed in European folk medicine for its calming properties.^[2] Introduced to the Americas during colonial times, chamomile was adopted by early settlers and Native Americans for similar therapeutic purposes, gaining popularity in the Middle Ages and Victorian era for both medicinal and aromatic applications.^[5] In modern contexts, chamomile is widely cultivated globally— with Hungary as a primary producer for German chamomile—and used primarily for its dried flowers in herbal teas, tinctures, and extracts, as well as in cosmetics, perfumes, and potpourri due to its apple-like aroma.^[2]^[3] It is promoted for relieving anxiety, indigestion, colic, and skin irritations, with preliminary scientific evidence supporting mild benefits for generalized anxiety disorder, wound healing, and as a mouth rinse for oral mucositis in cancer patients, attributed to bioactive compounds like the essential oil components chamazulene and α-bisabolol, which confer anti-inflammatory, antispasmodic, and antimicrobial effects.^[1]^[2] German chamomile is generally recognized as safe (GRAS) for use in foods and teas, though it may cause allergic reactions in individuals sensitive to ragweed or related plants and is toxic to pets like dogs and cats.^[1]^[5] Cultivation is straightforward in well-drained soils and full sun, with the plant self-seeding readily and attracting pollinators like bees and butterflies.^[3]^[5]

Taxonomy and nomenclature

Etymology

The term "chamomile" originates from the Ancient Greek word chamaimēlon (χαμαίμηλον), a compound of chamai (χαμαί, meaning "on the ground" or "earth") and mēlon (μῆλον, meaning "apple").^[6]^[7] This etymology reflects the plant's low, ground-hugging growth habit and its distinctive apple-like aroma, as noted in classical botanical descriptions.^[8]^[9] The name evolved through Late Latin chamomilla or camomilla, directly adapted from the Greek, which influenced Old French camomille or camemile.^[10] By the 13th century, it entered Middle English as camomille, first attested around 1265, and later standardized as "chamomile" in modern English.^[11] In Old English, the plant was referred to as mæġþe or maythe, a term possibly linked to its meadow-dwelling nature and used for species like chamomile or the related mayweed (Anthemis cotula).^[12]^[13] Common names distinguish between the two primary species: Matricaria chamomilla, known as German chamomile, and Chamaemelum nobile, called Roman chamomile.^[14]^[15] Historical linguistic variations persist across languages, such as French camomille (for both species, with qualifiers like camomille allemande for the German variety) and German Kamille (with echte Kamille for M. chamomilla and römische Kamille for C. nobile).^[7]^[16]^[17]

Species and varieties

Chamomile primarily refers to two species in the Asteraceae family: Matricaria chamomilla L., commonly known as German chamomile, and Chamaemelum nobile (L.) All., known as Roman chamomile. Matricaria chamomilla, an annual herb, belongs to the genus Matricaria in the tribe Anthemideae and subfamily Asteroideae; it is diploid with 2n=18 chromosomes and exhibits allogamous reproduction.^[18] Its synonym Matricaria recutita L. is widely used in botanical nomenclature.^[19] In contrast, Chamaemelum nobile, a perennial herb native to western Europe, is classified in the genus Chamaemelum within the same family and tribe.^[3] A key taxonomic distinction between these species lies in their flower head structure: M. chamomilla features a hollow receptacle in its daisy-like capitula, while C. nobile has a solid receptacle.^[18] Leaf morphology also differs, with M. chamomilla bearing alternate, double-pinnate, thread-like leaves up to 3 inches long, and C. nobile displaying more fern-like, finely divided foliage on shorter, creeping stems.^[3] Several related species in the Asteraceae family bear the name "chamomile" but are not true chamomiles, as they belong to different genera and lack the characteristic essential oil profiles or medicinal attributes. For instance, Anthemis arvensis L., known as corn chamomile or field chamomile, is an annual in the genus Anthemis and is often confused with true chamomiles due to superficially similar daisy-like flowers, but it produces no apple-like aroma and has a different chemical composition. Similarly, Tripleurospermum inodorum (L.) Sch. Bip., or scentless chamomile, belongs to the genus Tripleurospermum and is distinguished by its lack of fragrance when crushed, unlike the aromatic true chamomiles in Matricaria; its seeds are also ridged and dark brown.^[20] Cultivated varieties of German chamomile include both diploid and tetraploid (2n=36) forms, with tetraploids developed through colchicine treatment to enhance agronomic traits. These tetraploid varieties, such as those derived from induced polyploidy, exhibit larger flower heads and increased biomass, leading to higher essential oil yields per plant compared to diploids, though oil percentage remains similar.^[21] Notable tetraploid cultivars include selections like "Bona" and "Kosice-II," selected for improved oil content and uniformity.^[18]

Botanical characteristics

Morphology

Chamomile plants, primarily represented by the annual German chamomile (Matricaria chamomilla) and the perennial Roman chamomile (Chamaemelum nobile), exhibit distinct morphological features adapted to their growth habits. German chamomile grows as an erect annual herb reaching 15–60 cm in height, with a heavily branched, smooth stem that supports a bushy form.^[22] In contrast, Roman chamomile forms a low-growing, mat-like perennial, typically 15–30 cm tall but spreading up to 30 cm wide via creeping, rooting stems that are slightly hairy.^[8]^[23] The root systems differ markedly between the species, reflecting their life cycles. German chamomile develops a shallow, fibrous root system with thin, spindle-shaped roots that penetrate only flatly into the soil, aiding quick establishment in disturbed areas.^[22] Roman chamomile, being perennial, possesses a fibrous, rhizomatous root system that is relatively shallow and enables vegetative spread through clonal offsets.^[23] Leaves are alternate on both species, with a feathery, dissected appearance that enhances their aromatic profile. In German chamomile, the long, narrow leaves are bipinnate to tripinnate, glabrous, and measure up to 7.5 cm in length, arranged sparsely along the stems.^[22]^[3] Roman chamomile leaves are similarly finely divided and fern-like, bipinnate or tripinnate, but slightly hairy on the undersides and up to 5 cm long, contributing to the plant's evergreen mat formation.^[8] The flowers are daisy-like capitula characteristic of the Asteraceae family, featuring white ray florets surrounding a central cluster of yellow disc florets. German chamomile produces numerous pedunculate flower heads, 10–30 mm in diameter, borne in panicled corymbs; each head has 10–25 white ray florets, 6–11 mm long, around a conical, hollow receptacle of tubular disc florets.^[22]^[3] Roman chamomile bears solitary flower heads, up to 25 mm across, rising above the foliage on short stems; these have 10–20 white ray florets encircling a solid, hemispherical disc of yellow florets.^[23] Species variations include greater stem branching and higher flower density in the upright German chamomile compared to the more prostrate, sparsely flowered Roman form.^[22]^[8]

Habitat and distribution

German chamomile (Matricaria chamomilla), also known as wild chamomile, is native to a broad region encompassing Macaronesia, North Africa, and temperate Eurasia extending to Indo-China, including countries such as Afghanistan, Algeria, China, Finland, Iran, Italy, Morocco, and Türkiye.^[24] It has been introduced and naturalized in various parts of North America, such as Alabama, Alberta, Arizona, British Columbia, California, and Texas, as well as in New Zealand and parts of South America including Bolivia, Colombia, Ecuador, Peru, and Uruguay.^[24] This annual herb thrives primarily in the temperate biome and is often found in disturbed habitats.^[24] Roman chamomile (Chamaemelum nobile), a perennial species, is native to the Azores, western Europe, and northwestern Africa, with particular prevalence in temperate areas of the United Kingdom and France.^[25] It favors temperate climates and has been introduced and naturalized in North America, primarily in urban settings, as well as in Australia and southern South America.^[23]^[26] Like its German counterpart, it grows in the temperate biome and is adapted to open, disturbed environments.^[25] Both species prefer well-drained sandy or loamy soils in full sun, with a soil pH range of 5.6 to 7.5, and they tolerate drought but are sensitive to waterlogging.^[2] German chamomile additionally withstands saline-alkaline conditions up to pH 9.2 and cold temperatures from 2°C to 20°C, while Roman chamomile thrives in moist to mesic loam or sandy loam.^[2]^[23] Ecologically, chamomiles are common in grasslands, roadsides, railroads, and waste areas, where they act as opportunists in disturbed sites and can exhibit invasive potential in non-native regions like North America and Australia.^[27]^[26] Current global distribution reflects ongoing cultivation expansion, with significant production in Australia and South America alongside traditional European strongholds like Hungary and Germany, driven by demand for herbal and medicinal uses.^[2]^[26]

History and cultivation

Historical descriptions

Chamomile has been referenced in ancient medical texts for its therapeutic potential. The Greek physician Hippocrates, around 400 BCE, mentioned chamomile once in his writings, prescribing it for the treatment of fevers among other ailments.^[9] In the 1st century CE, Pedanius Dioscorides detailed its applications in De Materia Medica, highlighting its use for digestive complaints including stomachache, gas, colic, and jaundice, as well as for liver issues and as a general warming and thinning agent to reduce bodily excesses.^[9] Roman physicians, influenced by these Greek sources, incorporated chamomile into treatments for brain disorders, stomach problems, and as a component in baths and incenses.^[28] During the medieval period, chamomile found a place in European monastic gardens, where monks cultivated it as part of infirmary herb collections for healing purposes, reflecting its continuity in traditional medicine.^[29] In the Renaissance, the Swiss physician and alchemist Paracelsus (1493–1541) included Roman chamomile (Anthemis nobilis) in his herbal compendium, praising its versatility in medicinal preparations derived from its flowers.^[30] English herbalist Nicholas Culpeper, in his Complete Herbal of 1653, described chamomile's oil as effective against hard swellings, pains, cramps, and joint issues, and noted its role in dissolving knots, allaying swellings, and drying moist ulcers when boiled with other herbs, positioning it as a supportive agent in wound care.^[31] By the 18th and 19th centuries, chamomile's prominence grew in formal herbal compendia, with its first listing in the Pharmacopoeia of Württemberg in 1741 as a carminative, painkiller, diuretic, and digestive aid.^[32] This period marked a shift from primarily wild foraging to more organized cultivation, particularly in Europe, where garden-scale production expanded by the late 1800s to meet rising demand for medicinal and aromatic uses, laying the groundwork for commercial interest.^[33] In the 20th century, it remained a staple in German herbal traditions, known as Kamillentee, underscoring its enduring role in everyday remedies.^[34]

Agricultural practices

Chamomile, primarily German chamomile (Matricaria chamomilla), is typically planted via direct seeding in spring or autumn, depending on the region, to align with cooler temperatures that favor germination. Seeds are sown at a rate of 2–2.5 kg per hectare for direct field planting, often mixed with sand for even distribution at a depth of about 2 cm, while row spacing ranges from 20–30 cm and plant spacing from 10–30 cm to optimize airflow and yield. Transplanting from nurseries is also common in areas like North India, where seedlings raised post-monsoon are ready in 4–5 weeks and planted in October for better establishment in well-drained, sandy loam soils with a pH of 5.6–7.5.^[35]^[2]^[36] The growth cycle for German chamomile lasts 90–120 days from sowing to first harvest, with flowering occurring 60–70 days after planting under optimal conditions of 18–25°C daytime temperatures. In temperate regions, sowing in September–October leads to harvesting from March–May, allowing for 4–5 successive flushes of blooms if managed properly. Roman chamomile (Chamaemelum nobile), a perennial variety, has a longer cycle, enabling multiple harvests over 2–3 years from a single planting, typically established by seed or division in spring with similar spacing but requiring protection from winter cold in non-native areas.^[35]^[2]^[3] Harvesting occurs at full bloom to maximize essential oil content, primarily through manual picking for German chamomile, which is labor-intensive and accounts for a significant portion of production costs, though mechanical cutting is increasingly used in large-scale operations. Flowers are cut just below the head and dried in the shade or at low temperatures around 40°C for 3–4 days to preserve volatile oils like chamazulene, yielding 500–800 kg of dried flowers per hectare on average, with up to 1–1.5 tons possible under optimal conditions. For Roman chamomile, harvesting involves clipping flower heads multiple times per season, with drying methods similar to those for the German variety.^[35]^[2]^[36] Common pests include aphids, thrips, and the bug Nysius minor, while diseases such as powdery mildew and white rust can reduce yields if unchecked. Management in conventional systems involves targeted applications of approved fungicides like triazoles (e.g., tebuconazole) for mildew or insecticides like malathion (0.2%) for aphids, applied during early infestation stages. Organic approaches favor biological controls, such as neem-based sprays or beneficial insects, and crop rotation to minimize chemical residues that may compromise oil quality, with studies showing organic methods yielding comparable results in low-input systems.^[35]^[2]^[36] Global production of German chamomile is led by countries like Hungary, Egypt, Germany, and India, with Hungary as the largest producer at approximately 8,000 tons of dried flowers annually as of 2021 and global output exceeding 10,000 tons. Average yields range from 500–800 kg of dried flowers per hectare in conventional farming, higher in irrigated or saline-tolerant systems reaching 1.5 tons per hectare. Roman chamomile production is smaller and more localized to Europe and North America, focused on niche markets.^[2]^[37]^[35] Sustainability challenges include moderate water requirements, with 4–6 irrigations needed during dry periods to avoid stress that reduces flower quality, particularly in arid production areas like Egypt. Pesticide residues from conventional practices can persist in oils, prompting a shift toward organic certification to meet export standards and reduce environmental impact. Climate change exacerbates yield variability through increased drought and temperature fluctuations, with research indicating that abiotic stresses like cold can boost oil content but overall diminish harvests by 20–30% without adaptive measures such as proline supplementation.^[35]^[2]^[36]

Common uses

Culinary applications

Chamomile is most commonly employed in culinary contexts as an herbal tea, prepared by steeping dried flowers of Matricaria recutita (German chamomile) in hot water for 5 to 10 minutes to yield a mild infusion with an apple-like flavor and subtle herbaceous notes.^[38]^[39] The flowers are typically harvested in the morning after dew has evaporated but before midday heat, rinsed gently in cool water, and dried in a single layer in a shaded, airy space to preserve their delicate aroma; once dried, they can be stored in airtight containers for up to a year.^[39] In Germany, Kamillentee blends often incorporate these flowers as a base, sometimes combined with other herbs like peppermint for added complexity in beverages.^[40] Beyond teas, chamomile infusions feature in various desserts and confections, where the flowers are steeped in milk, cream, or sugar syrups to impart their floral essence to items such as panna cotta, ice creams, jams, and candies.^[41] For instance, the flowers can be added to crème anglaise bases for custards or used to flavor liqueurs, including vermouth-style infusions and Spanish manzanilla sherry, enhancing their bittersweet profiles without overpowering other ingredients.^[42] In modern applications, fresh chamomile petals serve as garnishes in salads or smoothies, providing a bright, tangy contrast, while infused oils or vinegars add nuance to dressings and marinades.^[38] These uses emphasize chamomile's role as a versatile flavor enhancer rather than a dominant element. Nutritionally, brewed chamomile tea is low in calories, with approximately 2 calories per 8-ounce cup, negligible fat and protein, and minimal carbohydrates at about 0.47 grams, making it suitable for flavoring without significant caloric contribution. It contains trace amounts of vitamins A and C, though these are not substantial enough to serve as a primary nutritional source, positioning chamomile primarily as a gastronomic accent.^[44] Varietal differences influence culinary selections: German chamomile yields a stronger, slightly bitter infusion ideal for robust teas and extracts, while Roman chamomile (Chamaemelum nobile) offers a milder, sweeter profile better suited for delicate garnishes in salads or lighter desserts.^[15]^[45]

Medicinal and therapeutic uses

Chamomile has been employed in traditional medicine for centuries as a digestive aid, particularly to alleviate indigestion and intestinal spasms. Herbalists have long recommended it to soothe upset stomachs and promote gentle relief from colic and bloating in folk practices across Europe and Asia.^[34]^[46] Its anti-inflammatory properties have also made it a staple remedy for external applications, such as treating skin irritations, minor wounds, and rashes through poultices or baths in various indigenous healing traditions.^[34]^[47] In traditional formulations, chamomile is commonly prepared as teas, tinctures, or ointments to harness its therapeutic potential. For instance, cooled chamomile infusions have been used as eye washes in European folk medicine to ease conjunctivitis and soothe inflamed eyes, often applied with a clean cloth for gentle relief.^[48]^[49] Tinctures, made by steeping the flowers in alcohol, and ointments, blended with bases like beeswax, have been applied topically for skin conditions or ingested in small doses for internal complaints.^[49] Across cultures, chamomile holds specific roles in herbal lore. In Ayurvedic tradition, known as "babune ka phool," it is valued for its calming effects on the mind and body, often incorporated into herbal blends to reduce agitation and support emotional balance.^[50] Native American communities have traditionally used chamomile infusions to address cold symptoms, such as sore throats and congestion, by drinking the tea or inhaling steam from the preparation.^[51] In aromatherapy practices rooted in herbal traditions, chamomile essential oil is inhaled to promote relaxation and ease anxiety, typically diffused or added to a warm bath for a soothing atmosphere. Massage blends incorporating diluted chamomile oil have been applied to tense areas to encourage muscle relaxation and alleviate discomfort from daily stresses.^[52]^[53] Herbal traditions suggest a daily dosage of 1 to 4 grams of dried chamomile flowers, often divided into multiple infusions or capsules, though this is not a substitute for professional medical advice.^[46]^[54]

Cosmetic and other uses

Chamomile extracts and oils are widely incorporated into cosmetic formulations for their soothing properties on sensitive and irritated skin. In products such as lotions, creams, and shampoos, chamomile serves as a skin-conditioning agent, helping to alleviate conditions like eczema and minor irritations through its anti-inflammatory flavonoids.^[55] The Cosmetic Ingredient Review Expert Panel has assessed chamomile-derived ingredients, including Matricaria recutita flower extract, as safe for use in cosmetics when formulated to be nonsensitizing, with reported concentrations up to 0.5% in leave-on products and up to 1% in rinse-off products.^[56] Additionally, chamomile's apigenin content contributes to subtle hair lightening effects, particularly when used in rinses or shampoos for blonde or light brown hair, by gradually brightening tones upon sun exposure without penetrating the hair shaft.^[57] Chamomile essential oils, primarily extracted from the flowers of German (Matricaria recutita) and Roman (Chamaemelum nobile) varieties via steam distillation, yield between 0.2% and 1.7% depending on the species, with German chamomile typically at the lower end.^[58] These oils are valued in perfumery for their sweet, herbaceous notes and in soaps and detergents for their mild, calming aroma that enhances product appeal.^[59] The oils' antioxidant and antimicrobial attributes further support their inclusion in cosmetic blends, promoting formulation stability.^[59] Beyond personal care, chamomile finds application as a natural insect repellent in garden settings, where its essential oils demonstrate repellency against mosquitoes and ticks.^[60] The dried flowers of Matricaria recutita can also be used to produce yellow-brown dyes for fabrics like wool and cotton, employing alum mordants to achieve warm, subtle shades in ecological dyeing processes.^[3] In veterinary contexts, chamomile is employed as a mild sedative for pets, particularly dogs, to promote relaxation and reduce anxiety, though it can be toxic to cats and in high doses for dogs, administered via teas or supplements at safe dosages under veterinary guidance.^[61] Industrially, chamomile volatile oils flavor tobacco products, imparting a subtle herbaceous note in cigarette blends as documented in ingredient disclosures.^[62] In pharmaceuticals, chamomile extracts function as excipients in formulations, aiding in product stability and sensory attributes, with essential oils certified for use in oral care and topical preparations.^[63] The demand for chamomile in natural beauty products has driven market expansion, with the global chamomile extracts sector projected to grow from USD 1.2 billion in 2025 to USD 3.9 billion by 2035, fueled by consumer preference for organic ingredients in skincare and haircare.^[64] This trend aligns with broader shifts toward plant-based cosmetics, where chamomile's versatile applications contribute to sustainable product innovation.^[65]

Scientific research

Phytochemical composition

Chamomile, particularly Matricaria recutita (German chamomile) and Chamaemelum nobile (Roman chamomile), contains a diverse array of phytochemicals responsible for its therapeutic properties. The primary constituents include essential oils, flavonoids, coumarins, terpenoids, and polysaccharides, with variations influenced by species, growing conditions, and extraction techniques.^[14]^[66] Essential oils constitute 0.4–2% of the dry flower weight, comprising over 100 volatile compounds such as sesquiterpenes and monoterpenes. Key components include α-bisabolol (up to 50% in some varieties) and chamazulene (1–15%), both noted for anti-inflammatory effects, along with β-farnesene and bisabolol oxides. German chamomile is richer in chamazulene, contributing to its deep blue oil color, while Roman chamomile features higher levels of esters like angelic and tiglic acid derivatives. Terpenoids, including these sesquiterpenes, make up 35% of the oil in German chamomile compared to 3% in Roman, with monoterpenes at 1–5% across species.^[14]^[67]^[66] Flavonoids, primarily antioxidants, are abundant in the flowers, totaling 0.16–0.82% dry weight, among which the major components include apigenin (up to ~68% of flavonoids, or 0.3–0.5% dry weight), luteolin (1.9–2.2 mg/g dry weight), with quercetin and patuletin comprising smaller proportions of the flavonoid fraction (e.g., ~10% and ~7%, respectively) as major glycosides and aglycones. Coumarins such as herniarin, umbelliferone, and 7-methoxycoumarin occur at around 0.1%, often in methanolic extracts. Polysaccharides, comprising 1.29–3.25% of the biomass, include arabinose, galactose, xylose, and uronic acids, forming polyphenolic conjugates. German chamomile generally exhibits higher flavonoid and terpenoid levels than Roman chamomile.^[14]^[67]^[66] Extraction methods vary to target specific compounds: steam distillation or hydrodistillation isolates essential oils, while solvent extraction (e.g., Soxhlet with methanol) recovers polar flavonoids and coumarins effectively. Supercritical CO₂ extraction, often at 90–200 atm and 40°C, yields 4.4 times more essential oil than steam distillation in 30 minutes and 71.4% recovery of apigenin compared to solvent methods, though it requires modifiers like 5% methanol for polar compounds; this technique preserves heat-sensitive terpenoids without solvent residues. Analytical techniques such as gas chromatography-mass spectrometry (GC-MS) profile essential oils, revealing regional variability (e.g., higher chamazulene in Moroccan samples at 26.11%), while high-performance liquid chromatography (HPLC) or ultra-performance liquid chromatography (UPLC-UV) quantifies flavonoids.^[68]^[69]^[66] Supplements are standardized to ensure potency, such as ≥0.25% apigenin-7-glucoside per European Pharmacopoeia or ≥1.2% apigenin in some formulations. Recent 2020s studies highlight composition variability due to ecological factors, drying methods, and genotypes; for instance, soil and climate influence terpenoid yields, with Egyptian samples showing altered flavonoid profiles post-drying.^[14]^[66]

Evidence for health benefits

Scientific research on chamomile's health benefits has primarily focused on its potential therapeutic effects through randomized controlled trials (RCTs) and systematic reviews, often attributing efficacy to compounds like apigenin and chamazulene. While preclinical studies suggest mechanisms such as antispasmodic and anti-inflammatory actions, human evidence remains mixed, with many trials showing mild benefits but calling for more robust investigations.^[14]^[70] For digestive health, a 2015 RCT involving 45 patients with irritable bowel syndrome (IBS) found that chamomile extract significantly reduced symptoms, including abdominal pain and bloating, over four weeks compared to placebo, likely due to its antispasmodic properties. A 2022 comprehensive review supported these findings, noting chamomile's role in alleviating IBS-related inflammation through inhibition of pro-inflammatory cytokines in vitro, though it highlighted the need for larger clinical trials to confirm efficacy. Meta-analyses on herbal interventions for IBS have included chamomile, indicating mild symptom relief but not superiority over standard treatments.^[71]^[14]^[72] In the realm of sleep and anxiety, multiple RCTs from 2020 to 2024 have demonstrated chamomile's mild sedative effects, linked to apigenin's binding to GABA receptors in the brain. A 2019 meta-analysis of RCTs reported significant improvements in sleep quality (standardized mean difference = -0.73) and reduced generalized anxiety disorder symptoms after chamomile administration, with no major adverse effects. A 2024 systematic review of clinical trials further confirmed reductions in anxiety scores among patients with diagnosed disorders, though effects were modest and comparable to placebo in some cases.^[70]^[73] Chamomile exhibits anti-inflammatory properties in vitro, particularly through chamazulene, which inhibits leukotriene synthesis and promotes wound healing by modulating cytokine release. Human trials are limited; a double-blind study showed faster wound closure with chamomile extracts compared to controls, but results were inconsistent across sites. For dermatitis, small RCTs on atopic eczema found topical chamomile reduced inflammation and itching, though evidence remains preliminary due to small sample sizes. A 2025 meta-analysis of anti-inflammatory trials confirmed benefits for oral mucositis but noted limitations in broader applications.^[34]^[74]^[75] Other potential benefits include glycemic control and oral health support. A small 2022 RCT in patients with type 2 diabetes reported improved fasting blood glucose and HbA1c levels after eight weeks of chamomile tea consumption, corroborated by a 2023 meta-analysis showing favorable effects on glycemic markers. For oral health, chamomile rinses have been tested in RCTs for chemotherapy-induced mucositis, with a 2025 meta-analysis indicating significant reductions in severity and pain scores versus placebo.^[76]^[77]^[75] Despite these findings, gaps persist in the evidence base, including the need for larger, long-term RCTs to establish causality and optimal dosing. Chamomile holds FDA Generally Recognized as Safe (GRAS) status for food use, but it is not approved as a treatment for any specific disease, underscoring the reliance on further high-quality research.^[78]

Drug interactions

Chamomile may exhibit additive sedative effects when combined with central nervous system depressants such as benzodiazepines, barbiturates, and alcohol, potentially increasing the risk of drowsiness, dizziness, and impaired coordination.^[79]^[80] This interaction is attributed to chamomile's flavonoid apigenin, which binds to benzodiazepine receptors and modulates GABA activity, enhancing hypnotic effects.^[81] Additionally, chamomile inhibits cytochrome P450 enzymes, including CYP3A4, which may alter the metabolism of sedative drugs metabolized by these pathways, leading to elevated drug levels and intensified effects.^[82] Chamomile contains natural coumarins that can potentiate the anticoagulant effects of warfarin and other vitamin K antagonists, increasing the international normalized ratio (INR) and risk of bleeding.^[83] Case reports have documented severe internal hemorrhaging in patients consuming chamomile tea or using chamomile lotion while on warfarin therapy, with one instance involving a 70-year-old woman who required hospitalization after gastrointestinal bleeding.^[84]^[85] This pharmacodynamic interaction arises from chamomile's mild anticoagulant properties, which may synergize with warfarin to impair blood clotting.^[86] Beyond sedatives and anticoagulants, chamomile's phytoestrogenic compounds may interfere with hormone therapies, including tamoxifen, hormone replacement therapy, and estrogen-containing oral contraceptives, potentially altering their efficacy by competing for estrogen receptors.^[79] Individuals with allergies to plants in the Asteraceae family, such as ragweed, should avoid chamomile due to cross-reactivity, which can trigger symptoms like contact dermatitis, hay fever, or anaphylaxis.^[87]^[88] Healthcare providers recommend consulting a physician before using chamomile alongside medications, particularly for patients on CYP3A4 substrates like certain statins, immunosuppressants, or antiretrovirals, where high doses may lead to reduced drug clearance and toxicity.^[82]^[80] Monitoring is advised for those on multiple interacting drugs to mitigate risks.^[89]

Safety during pregnancy and breastfeeding

The safety of chamomile use during pregnancy remains uncertain due to limited human data, with authoritative sources recommending caution or avoidance. The National Center for Complementary and Integrative Health (NCCIH) indicates that little is known about its effects on pregnant individuals or fetuses, and animal studies suggest potential uterine stimulant properties that could lead to contractions or increased abortion risk at higher doses. For instance, research on isolated uterine tissue from animals has demonstrated spasmogenic effects of chamomile extract, supporting concerns for its abortifacient potential in large amounts. Consequently, high doses are advised against to minimize risks of preterm labor or other complications. Observational studies and case reports have linked chamomile consumption, particularly in the third trimester, to adverse outcomes such as increased odds of preterm birth, shorter newborn length, and low birth weight. One cohort analysis reported a higher incidence of preterm delivery among users (P < .002), while a case report described premature constriction of the fetal ductus arteriosus following maternal chamomile tea intake. Professional guidelines, including those from the Mayo Clinic, classify herbal teas like chamomile as potentially unsafe during pregnancy due to insufficient evidence on fetal impacts, aligning with recommendations to avoid non-caffeinated herbal products unless approved by a healthcare provider. A 2025 systematic review of peripartum chamomile use across cohort studies found no major adverse events at low doses (less than 1 g/day), though evidence remains limited.^[90] During breastfeeding, chamomile is generally considered safe in moderate amounts, though data are limited. The NIH's LactMed database notes no specific evidence of harm to nursing mothers or infants from typical use, but rare allergic sensitization is possible, especially in those with daisy family allergies. Possible sedative components may transfer into breast milk, potentially causing mild drowsiness in infants, and monitoring for such effects is advised. Allergic risks are heightened for sensitive individuals, as chamomile can trigger reactions similar to those from ragweed or daisies, manifesting as skin rashes or gastrointestinal upset; affected users should discontinue use and seek medical advice. Overall, pregnant and lactating individuals are encouraged to consult healthcare professionals before incorporating chamomile, prioritizing evidence-based alternatives.

Cultural and symbolic significance

In folklore and literature

In European folklore, chamomile held a prominent place among the Anglo-Saxons as one of the nine sacred herbs bestowed by the god Woden (Odin) to humanity for protection and healing, known as "maythen" in Old English texts like the Nine Herbs Charm from the 10th or 11th century.^[91] It was also incorporated into charms for prosperity, with traditions suggesting that carrying chamomile or washing hands with its infusion could attract good fortune.^[92] Chamomile appears in English literature as a symbol of resilience, notably in William Shakespeare's The Winter's Tale (Act 4, Scene 4), where Perdita describes the plant as thriving under adversity: "the camomile, the more it is trodden on, the faster it grows."^[93] Similarly, in Beatrix Potter's The Tale of Peter Rabbit (1902), Mrs. Rabbit administers chamomile tea to soothe her ailing son, reflecting its folkloric role as a gentle remedy for discomfort and illness.^[94] Symbolically, chamomile represented patience in Victorian flower language, often gifted to convey endurance in hardship, drawing from its unassuming growth amid trampling.^[95] In Celtic traditions, it embodied healing and spiritual harmony, with ancient practitioners using tinctures to mend wounds, ease pain, and restore balance to the body and spirit.^[96] Across global cultures, chamomile was linked to solar divinity in ancient Egypt, where its golden flowers were dedicated to the sun god Ra as a sacred emblem of renewal and protection against misfortune.^[97] In Chinese medicinal folklore, it was valued for calming the spirit and alleviating restlessness, integrated into traditional preparations to promote tranquility and emotional equilibrium.^[67] Medieval herbals featured detailed illustrations of chamomile, portraying it as a versatile remedy for ailments such as snake bites.^[98]

Modern cultural references

In contemporary film and television, chamomile often symbolizes relaxation and emotional healing. The 1992 BBC miniseries The Camomile Lawn, adapted from Mary Wesley's novel, features the herb as a recurring motif in scenes of wartime respite and personal reflection, highlighting its soothing cultural role. In animated media, chamomile tea appears in Disney's Tinker Bell and the Lost Treasure (2009), where characters brew it with honey for calming moments during adventures.^[99] Short films like Chamomile (2022), directed by an independent filmmaker, use the herb metaphorically in dreamlike narratives exploring inner emotions through surreal tea party imagery.^[100] Chamomile has inspired numerous songs in the 2020s indie music scene, evoking themes of comfort and introspection. Victoria Canal's "Chamomile" (2024) blends folk-pop with lyrics on gentle solace, while Field Medic's track of the same name (2021) draws on the herb's sweetness to reflect emotional vulnerability.^[101]^[102] Other examples include Ruth B.'s "Sweet Chamomile" (2021), a piano-driven ballad about tender relationships, and Runnner's upbeat "Chamomile" (2025), noted for its sweeping chorus and innovative production.^[103]^[104] In modern art, chamomile features prominently in botanical illustrations and watercolor paintings, such as minimalist still lifes by contemporary artists that emphasize its delicate petals for themes of serenity and natural beauty.^[105]^[106] Commercially, chamomile is a staple in branding for wellness products, particularly by tea companies like Celestial Seasonings, which markets its pure chamomile herbal tea as a caffeine-free aid for unwinding and stress relief, emphasizing its floral aroma and golden hue in packaging and campaigns.^[107] On social media platforms like TikTok, chamomile has fueled trends around sleep-enhancing "hacks," such as chamomile mocktails mixed with honey or lavender, promoted for their relaxing effects and shared in viral videos reaching millions of views.^[108] In events and practices, chamomile holds symbolic value in yoga and mindfulness communities, where its essential oil is diffused during sessions to promote calm, or its tea is sipped post-practice to enhance relaxation, as recommended in wellness guides.^[109]^[110] In Germany, chamomile appears in cultural harvest events like the SEKEM Festival, which celebrates organic farming and includes chamomile cultivation demonstrations tied to sustainable traditions.^[111] By 2025, chamomile has seen a surge in eco-friendly product integrations, with brands adopting compostable packaging for teas and extracts to align with sustainability narratives, driving market growth in organic segments.^[112]^[113]

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vellugtende kamille, Danish. echte kamille, Dutch. kamamil, Dutch. wild chamomile ... camomille allemande, French. camomille commune, French. camomille ordinaire ...
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French. Camomille Commune, Camomille D'Allemagne, Camomille Sauvage, Camomille Vraie, Matricaire Fausse Camomille, Matricaire Tronquée ; German. Echte Kamille.
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recutita LJ or German chamomile, native to most of Europe and known also as sweet or false chamomile, it is an annual species used for the sweet chamomile tea ...Missing: traits | Show results with:traits<|control11|><|separator|>
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Feb 12, 2023 · After the amazing SEKEM-Festival in Germany last year, we are thrilled to share more exiciting news with you: the second SEKEM-Festival will ...
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Sep 11, 2025 · Functional foods and beverages with botanicals like chamomile and lavender are emerging as popular natural sleep solutions. ... social media myths.