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Relaxer

A relaxer is a chemical treatment, typically in the form of a lotion or cream, applied to curly or coily hair to permanently straighten it by chemically breaking the disulfide bonds in the hair's keratin protein structure, thereby altering its natural curl pattern.^[1]^[2] Invented inadvertently in the early 1900s by African American inventor Garrett Augustus Morgan while experimenting with lubricants for sewing machine needles, the modern hair relaxer emerged from observations that certain chemical compounds relaxed tightly curled hair fibers.^[3]^[4] Morgan patented a version of the product, which gained popularity among Black communities seeking straighter hair textures amid cultural pressures favoring Eurocentric beauty standards, though it required careful application to avoid severe scalp burns and hair breakage due to its alkaline nature.^[5]^[6] Relaxers are classified primarily into lye-based (containing sodium hydroxide or similar strong alkalis for coarse, resistant hair) and no-lye varieties (using milder agents like guanidine hydroxide or ammonium thioglycolate for finer or sensitive scalps), with application times varying from 10 to 20 minutes depending on hair type and strength.^[7]^[8] While effective for achieving sleek, manageable styles, prolonged or frequent use has been associated with elevated health risks, including a significantly higher incidence of uterine cancer among users—particularly postmenopausal Black women—with studies showing up to a 30% increased risk for those applying relaxers more than four times per year.^[9]^[10] These findings, drawn from large-scale epidemiological data, highlight endocrine-disrupting chemicals like parabens and phthalates in many formulations as potential causal factors, prompting ongoing lawsuits and regulatory scrutiny despite industry defenses emphasizing proper use.^[11]^[12]

Overview

Definition and Chemical Mechanism

A hair relaxer is a chemical treatment formulated to permanently straighten curly, wavy, or coily hair by disrupting the structural integrity of its keratin protein chains.^[13] These products achieve this by targeting the disulfide bonds—covalent linkages between sulfur-containing cysteine amino acids in keratin—that dictate the hair's natural shape and resilience.^[14] The process involves two primary stages: reduction or hydrolysis of these bonds to soften and elongate the hair shaft, followed by neutralization to reform bonds in a straightened position under mechanical tension, such as combing or flat-ironing.^[15] This alteration is semi-permanent, persisting until new hair growth occurs, as the reformed bonds resist reversion to the original curl pattern.^[13] The chemical mechanism hinges on the biochemistry of α-keratin, which comprises approximately 14-18% cysteine residues forming up to 15-20% of the disulfide bonds responsible for hair's tensile strength and configuration.^[14] In alkaline relaxers, such as those containing sodium hydroxide (NaOH) at concentrations of 2-10%, the high pH (typically 12-14) causes the hair cuticle to swell, permitting hydroxide ions to penetrate the cortex and hydrolyze disulfide bonds (-S-S-) into l-cystine and lanthionine residues (-S-CH₂-), releasing hydrogen sulfide (H₂S) as a byproduct.^[16] This hydrolysis is irreversible, converting two disulfide bonds into one stable monosulfide bond per reaction, which locks the hair in its extended form after neutralization with an acidic agent like ammonium bisulfite or hydrogen peroxide.^[16] The reaction can be represented as: R-S-S-R + 2OH⁻ → R-S⁻ + R-S-CH₂-S-R + H₂S + H₂O, where R denotes the keratin polypeptide chain.^[16] Thio relaxers, employing thioglycolic acid derivatives like ammonium thioglycolate (ATG) at pH 8-10, operate via a reduction-oxidation cycle akin to permanent waving but inverted for straightening.^[7] The reducing agent donates electrons and hydrogen to cleave disulfide bonds into free thiol groups (-SH): R-S-S-R + 2HS-CH₂-COOH → 2R-SH + (S-CH₂-COOH)₂.^[14] Hair is then stretched straight, and an oxidizing neutralizer (e.g., hydrogen peroxide or bromate) reforms disulfide bonds in the new alignment: 2R-SH + H₂O₂ → R-S-S-R + 2H₂O.^[14] This method breaks fewer bonds (typically 20-30% versus 40-50% in alkaline types) and is less damaging to finer hair textures, though it requires precise timing to avoid over-processing.^[7] Both mechanisms exploit hair's hierarchical structure—cuticle, cortex, and medulla—but alkaline variants penetrate more aggressively due to their caustic nature, necessitating protective scalp barriers like petroleum-based pre-treatments.^[13]

Prevalence and Demographics

Hair relaxers are used predominantly by Black women in the United States, reflecting cultural preferences for straightened hair textures. A 2024 review of chemical hair relaxer safety reported that 94% of Black women under age 45 and 89% of those over age 45 in the U.S. had used relaxers.^[17] Historically, self-reported ever-use rates among adult Black women reached up to 95%, though recent data indicate a decline amid health concerns.^[18] Black women, who represent approximately 6.5% of the U.S. population, account for 60% of chemical straightener purchases.^[19] Usage often begins in childhood or adolescence. More than 50% of Black women in a large cohort study initiated relaxer use before age 10, with up to 96% reporting first application before age 19.^[20]^[21] Among adult African American women (mean age 47) in a New York-based study, 62% reported ever-use of chemical relaxers since age 20.^[22] In contrast, initiation rates before age 10 among non-Black women ranged from 1% to 17% in comparative analyses.^[23] While data on other racial groups are limited, relaxer use is far less common outside Black communities, with overall U.S. home relaxer usage trending downward—sales declined 26% from 2008 levels by the mid-2010s, comprising just 21% of Black haircare sales.^[24] Internationally, adoption is growing in African countries despite U.S. declines, driven by similar beauty standards.^[25] These patterns stem from targeted marketing and societal pressures, though self-reported surveys from health studies like the Black Women's Health Study provide the primary empirical basis, potentially subject to recall bias.^[18]

Historical Development

Origins in the Early 20th Century

The chemical hair relaxer originated from an accidental discovery by Garrett A. Morgan, an African American inventor and entrepreneur born in 1877, while he experimented with a lubricant solution for sewing machine needles in the early 1900s. Around 1905, Morgan noticed that the fluid, intended to reduce friction on wool fibers and straighten them during textile processing, had a similar effect on human hair when it contacted his skin or clothing, temporarily relaxing tightly coiled strands into a straighter form. This observation led him to refine the formula into a hair-straightening product, marking the first known chemical approach to permanently altering hair texture by disrupting disulfide bonds, unlike prior mechanical methods such as hot combs or pressing irons.^[26]^[3] Morgan formalized his invention through experimentation in his Cleveland-based repair shop, where he owned a sewing machine and shoe repair business by 1907. The resulting product, a cream-like solution applied to the scalp and hair, was designed specifically for coarse, kinky hair common among African Americans, offering a semi-permanent straightening effect that required less frequent reapplication than heat-based techniques. Although the exact chemical composition—likely involving mild alkaline agents derived from his industrial experiments—remains undocumented in patents, it represented a shift from temporary styling to structural modification, laying groundwork for later formulations. Morgan did not immediately patent the formula but incorporated it into his broader hair care innovations, including dyes and a straightening comb.^[27]^[28] In 1913, Morgan established the G.A. Morgan Hair Refining Company to commercialize the straightener, targeting Black communities seeking smoother hair textures amid cultural pressures for assimilation in urbanizing America. The company marketed the product door-to-door and through agents, achieving modest success before facing competition from emerging beauty entrepreneurs like Annie Turnbo Malone, whose 1902 serums emphasized non-damaging oils but relied more on conditioning than chemical restructuring. Morgan's relaxer, however, is widely recognized as the pioneering chemical variant, influencing subsequent industry developments despite limited scalability due to rudimentary application risks, such as scalp irritation from uneven processing. By the 1920s, refinements in similar formulas began addressing safety concerns, but early adopters reported variable efficacy, with results lasting 4-6 weeks depending on hair porosity.^[26]^[29]^[4]

Post-WWII Commercialization and Industry Growth

Following World War II, hair relaxers transitioned from primarily professional applications in barber shops—targeted at men—to more accessible consumer products suitable for at-home use by women, reflecting broader postwar economic expansion and rising demand in Black communities for hair straightening solutions.^[29] This shift was driven by innovations in formulation to reduce irritation and enable self-application, as earlier lye-based products from the 1910s onward had been harsher and salon-dependent.^[30] In 1954, George E. Johnson founded Johnson Products Company in Chicago, initially producing Ultra Wave, a pomade-based relaxer for men, before introducing Ultra Sheen in 1957 as the first commercial relaxer specifically formulated for women with a milder, lower-pH composition to minimize scalp damage during home use.^[31]^[32] This product marked a pivotal commercialization milestone, allowing broader adoption among Black women seeking straighter hair for professional and social assimilation amid postwar urbanization and workforce entry.^[33] Johnson Products' early success, starting with a $250 investment and handmade mixing, exemplified the growth of Black-owned enterprises in the ethnic hair care sector, which expanded as disposable incomes rose in the 1950s Black middle class.^[32] By the 1960s, the industry saw further innovation and market penetration, with Johnson Products launching Ultra Sheen No-Base in 1965—the first relaxer incorporating a protective cream base to shield the scalp, enhancing safety and user confidence for repeated applications.^[29] This period coincided with the proliferation of Black-owned hair care firms addressing textured hair needs unmet by mainstream brands, fueling sector growth through targeted marketing in urban areas and via beauty supply stores.^[34] The entry of stronger lye-based home kits, such as Soft Sheen's Dark & Lovely in 1971—which utilized sodium hydroxide for more potent straightening—further democratized access, transforming relaxers from niche salon treatments into a staple of the burgeoning Black beauty market valued for its reliability in achieving long-lasting results on coarse hair textures.^[35] Industry expansion accelerated into the 1970s, as non-Black conglomerates recognized the profitability of ethnic hair products; Revlon, for instance, launched its Realistic relaxer cream in 1979, the first major entry by a white-owned company into this segment, signaling mainstream validation and increased competition that boosted overall production and distribution.^[36] This commercialization wave was underpinned by postwar chemical advancements enabling stable, shelf-ready formulations, alongside cultural pressures for straightened hair in professional settings, which sustained demand despite emerging natural hair movements.^[37] By the late 1970s, the U.S. Black hair care industry had evolved into a multimillion-dollar enterprise, with relaxers comprising a core category due to their efficacy in altering protein bonds for semi-permanent straightening.^[38]

Chemical Types and Formulations

Thio Relaxers

Thio relaxers utilize ammonium thioglycolate as the principal reducing agent to straighten hair by disrupting the structural integrity of keratin. This compound, derived from thioglycolic acid, penetrates the hair shaft after application, targeting the cysteine-rich regions where disulfide bonds predominate.^[39]^[40] The core mechanism relies on reduction chemistry: the thioglycolate ion donates electrons to cleave disulfide bridges (-S-S-) into pairs of sulfhydryl groups (-SH), temporarily weakening the hair's polypeptide chains and allowing mechanical straightening via combing or pressing. Neutralization follows with an oxidizing agent, such as hydrogen peroxide at 1-2% concentration, which reoxidizes the sulfhydryl groups to reform disulfide bonds in the new, aligned configuration. This two-step redox process occurs at a pH of 9 to 9.5, sufficient to open the cuticle for diffusion without the extreme swelling induced by higher pH environments.^[13]^[40]^[13] In contrast to hydroxide relaxers, which employ alkaline hydrolysis to convert disulfide bonds into stable lanthionine linkages (-S-CH2-CH2-S-) via hydroxide ion attack, thio relaxers preserve the original bond reducibility, rendering the effect more amenable to reversal with reducing agents, though practical reversibility diminishes with fiber degradation. Protein loss from thio treatments averages 2.5 μg per gram of hair, comparable to sodium hydroxide applications, underscoring equivalent structural compromise despite the milder pH.^[41]^[41] Commercial formulations appear as viscous creams, gels, or liquids, often buffered with ammonia to maintain pH and incorporating emollients like mineral oil or proteins to offset tensile loss and elasticity reduction post-treatment. Strengths vary for hair types—mild for fine textures, regular for medium—applied for 10-20 minutes at 25-40°C to optimize efficacy while minimizing over-processing. Compatibility issues arise with prior hydroxide use, as residual alkalinity can destabilize thioglycolate, risking uneven results or breakage.^[13]^[40] Efficacy stems from targeted bond disruption, achieving 70-90% straightness retention initially, but longevity depends on neutralization thoroughness; incomplete oxidation leaves residual thiols, promoting hydrolytic weakening over time. Safety profiles indicate ammonium thioglycolate as a moderate irritant in 5-10% solutions typical for relaxers, with potential for allergic contact dermatitis in sensitized individuals, though systemic absorption via intact scalp remains low. Longitudinal data link frequent use to elevated protein degradation and tensile strength decline by up to 50% after multiple cycles, advising interval spacing of 8-12 weeks.^[41]^[42]^[41]

Alkaline Relaxers

Alkaline relaxers constitute a primary category of chemical hair straightening agents that employ hydroxide salts to permanently alter the structure of curly or kinky hair through alkali-induced hydrolysis of disulfide bonds in keratin proteins. These formulations achieve straightening by swelling the hair cuticle at high pH levels, typically 12 to 14, allowing penetration into the cortex where cystine residues are converted to lanthionine, resulting in shortened polypeptide chains and irreversible bond reconfiguration.^[43]^[44] This process contrasts with reductive mechanisms in thio relaxers, which operate at pH 9–10 using thioglycolate to cleave bonds reversibly via hydrogen addition, often requiring oxidation for neutralization; alkaline variants produce thicker creams for controlled application and yield more uniform results on coarse textures but demand precise timing to avoid over-processing.^[7]^[41] Formulations of alkaline relaxers primarily feature sodium hydroxide (lye-based) or alternatives like guanidine hydroxide, calcium hydroxide combined with guanidine carbonate, or lithium/potassium hydroxides (no-lye variants), all maintaining corrosive alkalinity with median pH values around 12.36 (interquartile range 12.10–12.62) across tested products, including those marketed for children.^[45]^[46] Lye-based options, with pH often exceeding 13, excel in efficacy on resistant hair types due to rapid hydrolysis but increase risks of scalp irritation from direct contact, while no-lye types are promoted for reduced burn potential through slower action, though empirical pH data indicates comparable corrosivity and no significant mitigation in structural damage to hair shafts, such as elevated dehydroalanine formation and side-chain dehydration observed in hydroxide exposures.^[7]^[43] Both subtypes incorporate conditioning agents like oils or proteins to offset protein loss, yet the inherent high alkalinity drives protein denaturation, with studies documenting cytotoxic effects on skin cells at concentrations mirroring product actives.^[47]^[17]

Lye-Based Relaxers

Lye-based relaxers, also known as sodium hydroxide relaxers, employ caustic soda (NaOH) as the principal active agent, typically at concentrations ranging from less than 2.5% in mild formulations to higher levels in regular and super strengths for coarser hair textures.^[7] These formulations are premixed creams containing NaOH dissolved in water, combined with emollients such as mineral oil, petrolatum, propylene glycol, lanolin, cetyl alcohol, and emulsifying waxes to facilitate application and minimize immediate scalp contact.^[48] The high alkalinity, with pH values exceeding 13, enables rapid penetration by swelling the hair cuticle and hydrolyzing disulfide bonds in the keratin cortex, converting cystine residues to cysteine and cysteic acid, which permits permanent reshaping into a straightened configuration upon neutralization.^[49] Available in three primary strengths—mild for fine, color-treated, or previously damaged hair; regular for average textures; and super for resistant, coarse, or tightly kinky hair—lye-based products differ from no-lye alternatives by offering faster processing times (often 10-20 minutes) and more complete bond breakage, resulting in straighter, longer-lasting results on challenging hair types.^[50]^[44] Unlike guanidine or calcium hydroxide formulations in no-lye relaxers, which operate at pH 11-12 and require guanidine carbonate activation for slower, less aggressive action, lye variants do not necessitate on-site mixing and achieve greater efficacy on Type 4 (kinky) hair but demand precise timing to avoid over-processing.^[51] Scientific analyses confirm NaOH as the active ingredient in approximately 63% of tested alkaline relaxers, underscoring its prevalence in ionic hydroxide-based systems.^[52]

No-Lye Relaxers

No-lye relaxers, a variant of alkaline hair relaxers, primarily employ guanidine hydroxide as the active straightening agent, formed by combining calcium hydroxide with guanidine carbonate during mixing.^[46] Alternative formulations may incorporate lithium hydroxide or potassium hydroxide instead of sodium hydroxide found in lye-based products.^[51] These ingredients are typically packaged in multi-component kits, including a base cream, activator, and neutralizer, to facilitate on-site preparation and application.^[46] The chemical mechanism parallels that of lye relaxers, involving the hydrolysis of disulfide bonds within hair keratin under highly alkaline conditions, which swells the hair shaft and permanently alters curl patterns.^[17] Operating at a pH range of 11.2 to 13.4—median approximately 12.36—these products exhibit corrosivity comparable to lye relaxers, with no statistically significant pH differences observed across types.^[46]^[51] Marketed as gentler alternatives for sensitive scalps due to reduced caustic potential from guanidine or other hydroxides, no-lye relaxers nonetheless demand longer processing times for equivalent straightening, potentially exacerbating hair fragility and breakage risks over lye variants.^[17]^[46] Despite claims of lower irritation, their high alkalinity sustains hazards like scalp burns and dermatitis, underscoring that purported safety advantages stem more from formulation perception than empirical pH mitigation.^[51]^[17]

Specialized Variants

Texturizers constitute a specialized variant of chemical hair relaxers, formulated to partially loosen tight curl patterns in coarse or kinky hair while retaining some natural wave or coil for enhanced versatility in styling. These products utilize diluted concentrations of alkaline agents, such as calcium hydroxide, or thio compounds like ammonium thioglycolate, applied for shorter durations—typically 5 to 10 minutes—to achieve a softened texture rather than complete straightening.^[53] This approach breaks fewer disulfide bonds compared to full relaxers, reducing the extent of lanthionization and associated structural weakening, though the process remains irreversible on treated sections.^[54] Texturizers are frequently recommended for transitional users or those with finer, damage-prone hair seeking manageability without full curl elimination, with effects requiring reapplication to new growth every 6 to 8 weeks, akin to standard relaxers.^[53] Mild relaxers, another specialized category, target children, sensitive scalps, or previously damaged hair through reduced active ingredient levels, often no-lye formulations like guanidine hydroxide blended with emollients such as olive oil or shea butter. For example, the ORS Olive Oil Mild Touch Relaxer employs 60% fewer chemicals than regular strength products, aiming for 70% straightening while incorporating conditioning oils to counteract dryness and breakage.^[55] These variants prioritize gentler pH levels (around 9-11) and base formulations to buffer scalp contact, but clinical reviews indicate persistent risks of hair shaft fragility and irritant dermatitis due to the underlying caustic mechanism.^[17] Products marketed for pediatric use, such as no-lye kits with extra conditioning, claim suitability from age 5 onward but have drawn scrutiny for potential endocrine disruption and toxicity from fumes, even at lowered concentrations.^[56] Additional specialized formulations include strength-graded alkaline relaxers tailored for hair resistance levels—mild for fine or color-treated strands, regular for medium-coarse textures, and super for highly resistant kinky hair—allowing customized application to minimize over-processing.^[7] Soft-curl systems, combining low-dose thio relaxers with permanent waving agents on rods, further exemplify niche variants by enlarging existing curls rather than straightening, suitable for reshaping tightly coiled hair into looser patterns.^[57] Despite these adaptations, all variants rely on protein bond disruption, necessitating strand testing and professional oversight to avert scalp burns or tensile strength loss exceeding 50% in vulnerable hair.^[17]

Usage and Application

Application Procedures

Professional application of chemical hair relaxers begins with a client consultation to assess hair texture, condition, and history of prior treatments, followed by a strand test to determine processing time and suitability.^[58] Protective measures include applying petroleum jelly or a base cream around the hairline, ears, and neck to shield skin from chemical contact, and ensuring the client wears protective clothing.^[59] Hair is not shampooed prior to application to avoid swelling the cuticle and accelerating penetration.^[60] For virgin relaxers on untreated hair, the scalp is divided into four quadrants, with subsections no larger than 1/4 inch (6.35 mm) taken using clips.^[60] The relaxer cream is applied using a brush, starting at the mid-shaft and ends, then progressing to the scalp area last, maintaining at least 1/2 inch (12.7 mm) from the scalp initially to prevent overheating.^[58]^[60] Processing time varies by hair texture—typically 10-20 minutes for fine hair and up to 25 minutes for coarse—monitored via periodic strand checks for smoothness without breakage.^[58] In retouch applications for regrowth, the relaxer is confined to new growth only, avoiding overlap onto previously relaxed hair to minimize damage, with application starting from the nape and moving upward.^[58] Alkaline relaxers (lye-based with pH around 13 or no-lye variants) process faster due to their high alkalinity, requiring precise timing to avoid over-processing, while thio relaxers (pH 8-10) process more slowly, often allowing full-head application before monitoring.^[61]^[62] Upon reaching the desired straightness, the relaxer is rinsed thoroughly with warm water to remove all residue, followed by application of a neutralizing shampoo containing hydrogen peroxide or ammonium thioglycolate indicators that change color (e.g., from blue to white) to confirm pH neutralization to 4.5-5.5.^[60] Multiple shampooings ensure complete removal, after which a protein-based conditioner or reconstructive treatment is applied to restore moisture and strength.^[59] The process concludes with styling, emphasizing that improper application risks scalp burns or hair breakage.^[58]

Maintenance and Regrowth Management

Regrowth of chemically relaxed hair occurs at an average rate of 1 centimeter per month, resulting in visible curly roots that necessitate periodic touch-ups to sustain a uniform straightened appearance.^[63] Touch-up applications are typically performed every 6 to 8 weeks, though intervals may extend to 10 weeks depending on individual hair growth rates and tolerance for demarcation lines between relaxed and new growth.^[64] During touch-ups, the relaxer chemical is applied exclusively to the unprocessed regrowth at the scalp, with careful sectioning to avoid overlap onto previously straightened hair, which can cause structural weakening, breakage, or scalp irritation due to cumulative chemical exposure.^[65] Professional application is advised for touch-ups to ensure precise control over processing time and neutralization, minimizing risks of uneven results or damage; self-application increases chances of errors such as over-processing.^[65] Post-touch-up maintenance emphasizes restoration of hair integrity through weekly deep conditioning treatments to replenish moisture and lipids stripped by alkaline or thio-based formulations, alongside monthly protein treatments to reinforce the hair shaft against tensile stress from regrowth tension.^[66] Daily moisturizing with emollient products, protective styling to reduce manipulation, and avoidance of excessive heat tools help manage scalp health and prevent traction-related weakening at the root line.^[67] Trimming split ends every 6 to 8 weeks during touch-ups removes compromised lengths, promoting overall length retention despite chemical alteration, while clarifying shampoos used monthly remove buildup from conditioners and residues that could impede regrowth penetration.^[64] Transitioning from full-head relaxations to targeted regrowth management reduces long-term damage accumulation, as evidenced by dermatological recommendations to space applications and monitor for signs of scalp sensitivity or hair fragility.^[65]^[68]

Purported Benefits

Practical and Aesthetic Advantages

Hair relaxers chemically alter the disulfide bonds in curly or coily hair shafts, resulting in permanently straightened textures that reduce tangling and knotting compared to untreated hair. This structural change minimizes the formation of knots inherent in tightly coiled patterns, allowing for easier detangling and combing with less breakage during grooming.^[69] Users of relaxers on afro-textured hair often report decreased daily manipulation needs, as the smoothed cuticle resists frizz and holds styles without frequent reapplication of heat tools.^[70] Consequently, maintenance routines require less time, with estimates of hours saved weekly on stretching, blow-drying, or pressing, particularly beneficial for individuals with demanding schedules.^[71] Aesthetically, relaxed hair achieves a uniform, sleek appearance by flattening the hair shaft and enhancing light reflection for increased shine and silkiness. This transformation enables a broader range of styling options, from ponytails to updos, that may be challenging with highly coiled textures due to volume and elasticity differences.^[72] The straightened result also demonstrates resilience to environmental factors like humidity, preserving straightness and reducing reversion to curls that can disrupt visual consistency.^[73] Industry observations note that such outcomes contribute to perceived manageability and versatility, aligning with preferences for low-fuss, polished looks in professional or social contexts.^[74]

Socioeconomic and Professional Impacts

Studies have identified workplace biases against natural Black hairstyles, such as afros, braids, or twists, where Black women presenting with these styles are rated as less professional, less competent, and less likely to receive job interview recommendations compared to those with chemically straightened hair or white women regardless of hairstyle.^[75]^[76] This effect is more evident in conservative sectors like consulting than in creative fields like advertising, where appearance norms are less stringent.^[75] Such perceptions may incentivize relaxer use to align with dominant professional standards, potentially aiding hiring and advancement for affected women, though direct causal links to earnings remain unestablished in large-scale longitudinal data. Socioeconomically, Black women expend disproportionate resources on hair care, spending approximately four times more annually than white women—around $1.7 billion collectively in the U.S.—with chemical relaxers forming a key component due to the demands of maintaining straightened textures on coarse hair.^[77]^[78] This "hair tax" burdens lower-income households particularly, as 21% of Black women allocate over 25% of their monthly budgets to hair-related expenses.^[78] The ethnic hair care market, valued at $2.51 billion, reflects this demand, with Black consumers purchasing nine times more specialized products, including relaxers, than non-Black counterparts.^[79] Usage patterns correlate with socioeconomic status, wherein lower education and income levels predict higher adult relaxer application frequency, possibly due to limited access to costlier alternatives like salon treatments or natural hair regimens requiring more time and upkeep.^[22] Despite these investments yielding perceived professional conformity, emerging health risks from relaxers introduce long-term economic costs, including potential medical expenses, though short-term benefits in labor market navigation persist for some users.^[22] The U.S. relaxer segment, peaking at $206 million in 2008 before declining 26% by recent years amid health scrutiny, illustrates shifting consumer priorities.^[24]

Health Risks and Scientific Evidence

Local Effects on Hair and Scalp

Chemical hair relaxers induce permanent straightening by hydrolyzing disulfide bonds in the cysteine-rich alpha-keratin proteins of the hair cortex, which reduces the hair's natural curl pattern but compromises its structural integrity and mechanical properties.^[43] This process elevates the hair's pH to 12-14 in lye-based formulations (containing sodium hydroxide), leading to alkali-induced swelling of the cuticle and cortex, followed by breakage of up to 70-80% of disulfide linkages, resulting in weakened tensile strength, increased porosity, and heightened susceptibility to breakage and split ends.^[17] Amino acid analysis of relaxed hair reveals significant reductions in cystine content (the oxidized form of cysteine), correlating with diminished elasticity and shorter achievable hair lengths due to cumulative fragility.^[80] Empirical studies document widespread hair damage among users, with one survey of 180 women reporting adverse effects in 95.56% of cases, including frizzy texture (67%), dandruff (61%), and hair loss or thinning (47%).^[81] Another investigation found hair loss in 61%, dryness in 45%, thinning in 30%, and dandruff in 20% of participants, attributing these to repeated chemical exposure that erodes the cuticle layer and promotes longitudinal fractures.^[82] No-lye relaxers, utilizing guanidine carbonate or lithium hydroxide (pH 9-11), cause less severe bond cleavage but still induce comparable shaft weakening and color alterations over time, as evidenced by scanning electron microscopy showing cuticle erosion in treated samples.^[43] On the scalp, relaxers provoke acute and chronic irritant contact dermatitis due to their caustic nature, with lye variants posing higher risk of chemical burns from direct alkali penetration through micro-abrasions or prolonged application.^[83] Reported local reactions include erythema, edema, desquamation, pruritus, and pain, occurring in up to 30-50% of applications if neutralizing steps fail; severe cases manifest as blistering or ulceration, potentially scarring follicles and inducing traction alopecia.^[43] Even no-lye products elicit scalp burns at rates similar to lye types in user reports, linked to guanidine hydroxide formation and inflammatory cytokine release.^[20] Chronic exposure exacerbates these via cumulative barrier disruption, fostering secondary infections or seborrheic dermatitis, though patch testing underestimates risks due to occlusive application conditions.^[17]

Systemic Health Associations

Research has identified potential systemic health associations between chemical hair relaxer use and certain reproductive conditions, primarily through epidemiological studies examining absorption of relaxer constituents via scalp lesions or burns, which may facilitate entry of endocrine-disrupting chemicals such as parabens, phthalates, and guanidine compounds into the bloodstream.^[84] These chemicals have been hypothesized to mimic or interfere with estrogen signaling, potentially influencing hormone-sensitive tissues, though direct causation remains unestablished and confounded by factors like frequency of use, product formulation, and demographics.^[85] No-lye relaxers, which rely on guanidine carbonate and calcium hydroxide, may pose unique risks due to metabolites like glycolic acid derivatives that can lead to oxalate formation and acute kidney injury upon systemic absorption, as reported in case studies of overuse or improper application.^[17]

Links to Reproductive Cancers

A 2022 prospective cohort study from the National Institute of Environmental Health Sciences (NIEHS) Sister Study, involving 33,497 U.S. women followed from 2003 to 2018, found that frequent use of chemical hair straighteners (defined as four or more applications per year) was associated with a 2.1-fold increased risk of uterine cancer (endometrial carcinoma), with the risk rising to over 30% of cases attributable to such products among users.^[86] Black women, who reported higher prevalence of relaxer use (over 80% in the cohort), exhibited disproportionate exposure, potentially explaining elevated baseline uterine cancer rates in this group, though the study emphasized observational limits and called for mechanistic research on endocrine disruption.^[87] Earlier analyses from the Black Women's Health Study linked relaxer use to uterine leiomyomata (fibroids), with women applying relaxers every one to two weeks showing a 1.64 relative risk compared to non-users, attributed to enhanced dermal absorption through application-induced scalp irritation.^[84] Associations with other reproductive cancers have been inconsistent. A 2021 analysis of the Black Women's Health Study (n=49,514, followed 1997-2017) reported a 1.45-fold increased breast cancer risk among frequent users of lye-based relaxers, potentially tied to aromatic amines or formaldehyde releasers, but no elevation for no-lye variants.^[88] Ovarian cancer links remain tentative, with some cross-sectional data suggesting modest odds ratios but lacking longitudinal confirmation.^[83] A January 2025 systematic review of U.S. epidemiological data concluded no overall increased risk for breast, ovarian, or uterine cancers attributable to relaxer use in Black women, highlighting variability across studies and potential overestimation from self-reported exposure.^[89]

Other Potential Correlations

Beyond reproductive organs, relaxer constituents may contribute to broader endocrine disruptions, including earlier menarche and altered puberty timing in adolescent users, as evidenced by detection of phthalates and parabens in products marketed to Black girls.^[90] Preclinical data indicate these compounds can bind estrogen receptors or inhibit aromatase, supporting plausible systemic effects, though human trials are absent.^[17] Rare case reports document acute systemic toxicity, such as metabolic acidosis and renal oxalate nephropathy from excessive guanidine absorption in no-lye formulations, underscoring risks in sensitive individuals.^[83] No robust evidence links relaxers to non-reproductive cancers or cardiovascular outcomes, with most studies confined to associations rather than dose-response causality.^[91]

Links to Reproductive Cancers

A 2022 study analyzing data from the Sister Study cohort of 33,497 U.S. women aged 35-74 found that those who reported using chemical hair straighteners or relaxers in the 12 months prior to enrollment had a 1.3-fold increased risk of developing uterine cancer compared to non-users, with frequent users (more than four applications per year) facing a 2.55-fold higher risk.^[86] This observational analysis identified 378 incident uterine cancer cases over an average follow-up of nearly 11 years, attributing potential risks to endocrine-disrupting chemicals such as parabens and phthalates in these products, which may be absorbed through the scalp and mimic estrogen to promote hormone-sensitive tumor growth. The association was stronger among Black women, who comprised 7.6% of the cohort and reported higher product use, though the study noted limitations including self-reported exposure data and potential confounding from unmeasured factors like overall chemical exposures or socioeconomic status.^[86] Subsequent research in the Black Women's Health Study, involving over 28,000 participants followed from 1995 to 2019, reported that moderate or heavy use of chemical hair relaxers (defined as at least four applications per year for five or more years) was linked to a higher uterine cancer risk specifically among postmenopausal women, with a hazard ratio of approximately 2.1 for long-term users, but no significant association in premenopausal women.^[10] This finding, based on 252 incident cases, suggests possible interactions with menopausal status, potentially due to varying estrogen levels influencing chemical absorption or hormonal disruption effects.^[18] Earlier cohort studies had similarly associated hair relaxer use with elevated risks of ovarian cancer, another hormone-dependent reproductive malignancy, though with smaller effect sizes (hazard ratios around 1.2-1.5 for frequent users) and less consistent evidence across populations.^[17] These associations are hypothesized to stem from ingredients like sodium hydroxide, guanidine hydroxide, and formaldehyde-releasing agents in relaxers, which exhibit estrogenic activity and have been detected in high concentrations in product formulations marketed to women of color.^[17] However, causation remains unestablished, as randomized trials are infeasible, and critiques highlight challenges in isolating relaxer effects from co-exposures such as dyes or environmental endocrine disruptors, alongside recall bias in retrospective designs.^[92] No direct links to cervical or other reproductive cancers have been robustly demonstrated in peer-reviewed literature to date.^[93]

Other Potential Correlations

Studies have identified associations between frequent chemical hair relaxer use and increased risk of uterine fibroids (leiomyomata), with one analysis of Black women showing that straightener use was linked to higher prevalence of young-onset fibroids (diagnosed before age 36) and incident fibroids during follow-up.^[94] This connection is attributed to endocrine-disrupting chemicals such as phthalates and parabens in relaxers, which may promote estrogen-sensitive growths like fibroids through hormonal imbalance.^[17] However, confounding factors including socioeconomic status, diet, and genetic predispositions common in studied populations warrant caution in inferring direct causality.^[91] Potential links to endometriosis have been hypothesized due to the endocrine-disrupting properties of relaxer ingredients, which could exacerbate hormone-dependent conditions by mimicking or interfering with estrogen signaling.^[93] Yet, a systematic review of hair product use and gynecological disorders concluded that current evidence is insufficient to establish a definitive positive association with endometriosis, highlighting the need for larger prospective studies to disentangle correlations from other environmental exposures.^[93] Beyond gynecological issues, relaxers containing obesogenic endocrine disruptors have been implicated in metabolic disruptions, including potential contributions to obesity, chronic inflammation, and impaired glucose metabolism, though direct epidemiological links remain preliminary and require further validation beyond chemical content analyses.^[95] These effects stem from systemic absorption of compounds like bisphenol A analogs during scalp application, but population-level data controlling for lifestyle variables are limited.^[96]

Empirical Critiques and Confounding Factors

Studies associating hair relaxer use with systemic health risks, particularly uterine cancer, are predominantly observational and prospective, such as the Sister Study cohort of 33,947 women followed from 2003 to 2018, which reported a hazard ratio of 2.55 (95% CI: 1.27-5.12) for uterine cancer among frequent users (more than four times per year in the past year).^[86] However, these analyses often derive elevated risk estimates from small case numbers; for example, subgroup hazard ratios exceeding 2.0 were based on as few as 14 events, resulting in wide confidence intervals and heightened vulnerability to statistical instability or chance findings.^[97] Self-reported exposure data in such studies introduces measurement error, including potential inaccuracies in recall of frequency, duration, or specific products, despite the prospective design reducing differential bias relative to case-control approaches.^[98] ^[99] Inconsistencies across the literature further undermine causal inferences; a 2025 systematic review of eight U.S.-based studies among Black women found no overall increased risk of breast, ovarian, or uterine cancer linked to relaxer use, attributing mixed results to uncharacterized chemical compositions in products and failure to consistently demonstrate elevated incidence.^[89] Confounding factors complicate interpretation, as relaxer users often differ systematically from non-users in socioeconomic status, occupational exposures, physical activity levels, chronic stress, and co-use of other personal care products containing endocrine disruptors, residuals of which may persist after model adjustments for variables like BMI, smoking, education, and income.^[92] ^[98] Multiple environmental sources of similar chemicals (e.g., via diet or household products) obscure isolated effects, while historical shifts in formulations—from lye-based (sodium hydroxide) to no-lye variants with guanidine carbonate—render long-term exposure assessments imprecise and non-comparable.^[92] Causation remains unestablished absent randomized or mechanistic evidence, with critiques emphasizing that not all relaxer ingredients (e.g., sodium hydroxide) are carcinogenic and that systemic absorption levels may insufficiently elevate exposure for oncogenesis, particularly given rinsing protocols.^[98] Rising rates of non-endometrioid uterine cancers, which are less hormone-sensitive, challenge endocrine disruption hypotheses tied to relaxers, suggesting alternative drivers like obesity or genetic predispositions prevalent in studied demographics.^[98] Absolute risks, even in associated subgroups, remain low (e.g., projected lifetime incidence rising from 1.64% in never-users to approximately 4% in frequent users by age 70), underscoring the need for replication beyond initial associations.^[100]

Legal and Regulatory Landscape

Product Liability Litigation

In October 2022, following a National Institutes of Health study published in the Journal of the National Cancer Institute associating frequent use of chemical hair straighteners with a 1.8-fold increased risk of uterine cancer among postmenopausal women, a surge of product liability lawsuits emerged against manufacturers of relaxer products.^[101] These suits, primarily filed by Black women alleging diagnoses of uterine, ovarian, or breast cancers, claim that endocrine-disrupting chemicals such as parabens, bisphenol A, and formaldehyde in the products caused their injuries through absorption via the scalp, with defendants failing to warn of risks or design safer formulations.^[102] By October 2025, the multidistrict litigation (MDL No. 3060) in the U.S. District Court for the Northern District of Illinois had consolidated over 10,500 claims, marking it as one of the largest active MDLs.^[102] Major defendants include L'Oréal USA (brands like Dark & Lovely and SoftSheen-Carson), Strength of Nature (Olive Oil Relaxer), and Godrej (curl creme products), with allegations centering on strict liability for defective products, negligence in marketing, and breach of warranties.^[103] ^[104] Procter & Gamble has faced fewer direct claims but is implicated in broader scrutiny over industry practices.^[105] Plaintiffs, such as Jenny Mitchell who filed in 2022 alleging uterine cancer after decades of use, assert that companies knew or should have known of the dangers based on prior studies dating to the 1990s linking relaxers to scalp burns and chemical absorption.^[106] Defendants counter that the NIH study's observational design shows association, not causation, and that individual factors like genetics confound claims; however, in November 2023, U.S. District Judge Mary Rowland denied motions to dismiss, preserving failure-to-warn and design-defect counts while dismissing fraud allegations for lack of specificity.^[107] ^[101] No class-wide settlements have been reached as of October 2025, with discovery ongoing and bellwether trials scheduled to test case viability; estimates for individual settlements, drawn from analogous toxic exposure litigations like talc cases, range from $100,000 to $2 million per plaintiff, depending on injury severity, usage duration, and evidence of exposure.^[108] ^[109] The Georgia Supreme Court in 2024 upheld a lower court's reversal, allowing a suit against L'Oréal and Strength of Nature to proceed despite statute-of-limitations challenges.^[110] Amid the litigation, the FDA announced in 2023 plans to propose restrictions or a ban on certain relaxer ingredients, citing absorption risks, though no recalls have occurred.^[111] Law firm-driven filings dominate, raising questions about claim inflation, but the volume reflects widespread use among Black women, with over 300 initial suits by late 2022 escalating rapidly.^[112]

FDA Warnings and Industry Responses

In October 2023, the U.S. Food and Drug Administration (FDA) proposed a rule to prohibit formaldehyde and formaldehyde-releasing chemicals, such as methylene glycol, in hair smoothing and straightening products, citing the chemical's classification as a known human carcinogen by agencies including the National Toxicology Program and its association with adverse effects like respiratory irritation, skin burns, eye damage, and increased cancer risk upon scalp absorption and inhalation during application.^[113]^[114] The proposal targeted products heated to release formaldehyde gas, which can exceed safe exposure limits in salon settings, building on prior FDA actions including warning letters to manufacturers like GIB, LLC (Brazilian Blowout) in 2011 and Van Tibolli Beauty Corp. in 2019 for misbranding and safety violations related to undeclared formaldehyde levels.^[114] The FDA has also issued general consumer advisories on hair relaxers and dyes, emphasizing risks such as chemical burns, scalp irritation, hair breakage, and allergic reactions, while urging users to perform patch tests and report adverse events through MedWatch, as the agency monitors post-market safety but lacks pre-market approval authority for most cosmetics under the Federal Food, Drug, and Cosmetic Act.^[115] Implementation of the formaldehyde ban faced repeated delays, missing an initial April 2024 target and remaining in limbo as of October 2025 following a January 2025 executive order pausing new federal regulations under the Trump administration, amid critiques from lawmakers and advocates for insufficient progress despite evidence from occupational exposure studies and voluntary industry reporting.^[116]^[117]^[118] Hair relaxer manufacturers, including L'Oréal USA (producer of brands like Dark & Lovely and SoftSheen-Carson), have responded to FDA scrutiny and related litigation by asserting product safety when used as directed, denying causal links to cancers like uterine fibroids or malignancies based on observational data, and arguing that epidemiological studies fail to isolate product chemicals from confounding variables such as frequency of use or socioeconomic factors.^[119]^[102] In defense filings, companies have relied on expert testimony challenging causation, while some have reformulated offerings to eliminate formaldehyde—such as introducing no-lye or alternative straighteners—though traditional relaxers relying on sodium hydroxide or guanidine compounds continue sales with labeling warnings for burns and irritation, without broader concessions to regulatory bans.^[120] Industry groups have expressed uncertainty over prolonged FDA timelines but anticipate partial restrictions, prompting voluntary shifts toward lower-risk ingredients amid ongoing multidistrict litigation where plaintiffs allege failure to warn despite known endocrine-disrupting potentials in relaxer formulations.^[121]^[102]

Relaxation Practices in Black Communities

Chemical hair relaxers, which use alkaline agents like lye to permanently straighten curly or kinky hair textures common in individuals of African descent, have been a prevalent grooming practice in Black communities in the United States since the early 20th century.^[122] Invented by Garrett Augustus Morgan around 1909 as a chemical treatment for hair straightening, relaxers gained widespread adoption in the 1950s with lye-based formulations that provided longer-lasting results compared to earlier heat or pressing methods.^[5] This practice emerged amid broader cultural pressures to conform to Eurocentric beauty standards, where straighter hair was often associated with professionalism, social acceptance, and perceived manageability, particularly in educational and occupational settings.^[123] In Black communities, relaxer use has historically served practical and social functions, including easing daily styling routines for women with demanding schedules and facilitating styles aligned with workplace norms that favor less textured hair.^[124] Studies indicate high lifetime exposure rates: up to 95% of adult Black women in the U.S. reported ever using relaxers in earlier surveys, with 94% of those under 45 and 89% over 45 confirming use in more recent data from 2024.^[18]^[83] Application often begins early, with over 50% of Black women in one cohort initiating use before age 10, frequently under familial guidance to establish grooming habits.^[20] Community salons and at-home kits have reinforced this as a rite of passage, though motivations vary from maternal preferences for "manageable" hair to peer influences promoting straighter textures as a marker of neatness.^[22]^[124] Despite these entrenched patterns, relaxer practices have faced critique within Black communities for perpetuating internalized preferences for non-African hair phenotypes, a dynamic traced to post-slavery assimilation efforts and reinforced by media portrayals.^[125] The Black Power Movement of the 1960s-1970s countered this by advocating natural afros as symbols of cultural pride, temporarily reducing chemical straightening.^[126] However, relaxers resurged in subsequent decades for their convenience over alternatives like pressing combs, which require frequent reapplication.^[122] In the 2020s, awareness of potential health risks—such as associations with uterine cancer from longitudinal studies like the Black Women's Health Study—has prompted a shift toward natural hair retention or non-chemical methods in many U.S. Black communities.^[9]^[127] This "big chop" trend, amplified by social media and the CROWN Act legislation in multiple states since 2019 prohibiting hair-based discrimination, reflects growing prioritization of hair health over straightening, though usage persists for reasons of habit or limited access to alternatives.^[128] Surveys show declining reliance on relaxers among younger Black women, with natural styles now comprising a majority in urban styling preferences, signaling evolving community norms toward texture acceptance.^[129]

Debates on Natural Hair Versus Chemical Straightening

The natural hair movement, which gained prominence in the 2000s and 2010s among Black women, emphasizes embracing textured hair textures as a form of cultural affirmation and health prioritization, contrasting with the long-standing practice of chemical straightening via relaxers. Advocates argue that forgoing relaxers reduces exposure to potentially harmful chemicals like parabens and phthalates, which have been associated with endocrine disruption and elevated risks of uterine and ovarian cancers in epidemiological studies. For instance, a 2022 study in the Journal of the National Cancer Institute found that frequent use of hair straighteners was linked to a 1.64% lifetime risk of uterine cancer among users compared to 1.64% for non-users, though absolute risks remain low and confounding factors like socioeconomic status warrant further scrutiny. This movement posits that natural hair fosters self-acceptance, challenging historical pressures rooted in assimilation to Eurocentric beauty standards dating back to post-slavery eras.^[22] Opponents of chemical straightening, including public health researchers, highlight persistent high usage rates—89% of Black women over age 45 and 94% under 45 reported ever using relaxers in U.S. surveys—as evidence of entrenched cultural and practical barriers to transition.^[83] Personal testimonies and qualitative analyses indicate that natural hair requires more maintenance time and styling expertise, leading some women to revert to relaxers for convenience in daily routines or professional settings. A 2021 analysis noted a subset of women abandoning the natural hair trend due to challenges in managing coils and curls, particularly in humid climates or high-demand jobs. Market data further underscores this tension, with the global hair relaxer industry projected to grow from $717 million in 2024 to $839 million by 2029, suggesting sustained demand despite health warnings.^[130]^[131] Counterarguments in favor of chemical straightening emphasize individual autonomy and functionality over ideological narratives of empowerment. Sociological examinations reveal that Black women often cite practical benefits—such as easier combing, reduced breakage from heat styling alternatives, and perceived professionalism—rather than internalized self-hatred as primary motivations.^[123] In workplace contexts, surveys indicate that 52% of Black women perceive their natural hair as hindering career advancement, with textured styles rated 2.5 times more likely to be deemed unprofessional by evaluators in controlled experiments. This has fueled legislative responses like the CROWN Act, enacted in 10 states by 2023 and reintroduced federally in 2025, which explicitly prohibits discrimination based on natural hairstyles associated with race; proponents cite anecdotal cases of school suspensions and job rejections, though empirical evidence of widespread bias remains largely perceptual and contested under existing Title VII protections.^[132]^[133] Critics of such laws argue they may overpathologize grooming choices, ignoring data that voluntary hair alteration correlates with economic mobility in diverse fields.^[134] These debates extend to broader causal questions of agency versus systemic influence, with some analyses attributing relaxer persistence to generational norms and media portrayals rather than coercion alone. Longitudinal usage patterns show childhood initiation rates of 9% escalating to frequent adult application, underscoring habituation over acute discrimination.^[135] While natural hair proponents frame reversion as capitulation to bias, empirical critiques highlight confounding variables like product accessibility and personal aesthetics, advocating for informed choice informed by transparent risk disclosures rather than prescriptive cultural shifts.^[136]

Alternatives and Future Directions

Non-Chemical Straightening Methods

Non-chemical straightening methods encompass thermal and mechanical techniques that temporarily reshape curly or coiled hair by disrupting hydrogen bonds or applying physical tension, without inducing permanent structural changes to the hair's keratin proteins. These approaches contrast with chemical relaxers by preserving the hair's natural biochemistry, though they demand consistent reapplication and protective practices to mitigate cumulative damage. Empirical assessments indicate that such methods achieve variable straightness based on hair type, porosity, and environmental humidity, with tightly coiled (type 4) hair often yielding less durable results compared to looser waves.^[137] Thermal methods, primarily involving flat irons and blow dryers, apply direct heat—typically 300–450°F (149–232°C)—to elongate hair shafts by temporarily breaking disulfide and hydrogen bonds, allowing realignment upon cooling. Flat ironing sections of pre-conditioned hair under tension produces sleek results lasting 1–7 days, depending on aftercare; studies on heat-exposed hair fibers show reduced tensile strength after repeated passes exceeding 350°F without protectants, risking cortical protein degradation and increased breakage susceptibility. Blow drying with a round brush or tension comb, often concluding with cool air to set the style, similarly straightens via airflow and manual pulling, but scanning electron microscopy reveals cuticle lifting at high velocities or temperatures above 180°C. Heat protectants containing silicones or natural oils (e.g., argan) form barriers that lower effective temperatures by 20–50°C, per tensile testing data, thereby extending hair viability.^[138]^[139]^[137] Mechanical techniques avoid heat entirely, relying on stretching and drying under constraint to minimize curl rebound. Hair wrapping entails combing damp, conditioned hair straight, securing it around the head with pins or bands, and air-drying overnight, which elongates strands via sustained tension and reduces frizz by 30–50% in wavy-to-curly hair per stylist evaluations, though efficacy diminishes in high humidity. Banding or threading involves sectioning wet hair and applying elastic bands or threads at intervals to pull curls taut during drying, preserving length and pattern memory temporarily without thermal stress; pediatric guidelines note this suits children, avoiding burn risks while achieving modest straightening in textured hair. Plastic rollers on towel-dried hair, followed by diffuse drying, offer similar low-impact elongation, with user-reported durability of 2–5 days in low-humidity conditions. Limitations include incomplete straightening for kinky textures and potential tangling if tension exceeds hair elasticity, as measured in mechanical pull tests showing 15–25% strain tolerance before snapping.^[140]^[141]^[140] Overall, these methods prioritize safety by eliminating endocrine-disrupting chemicals like parabens or formaldehyde found in relaxers, with longitudinal hair health data favoring intermittent use over daily chemical exposure; however, overuse of thermal tools correlates with 20–40% reduced elasticity after 6 months, underscoring the need for moisture replenishment and style breaks to maintain follicle integrity.^[142]^[137]

Research into Safer Formulations

Efforts to develop safer hair relaxer formulations have primarily focused on reducing alkalinity and minimizing exposure to caustic agents like sodium hydroxide, which dominates traditional lye-based products with pH levels exceeding 13. In response, no-lye relaxers emerged in the late 1970s and 1980s, utilizing guanidine carbonate combined with calcium hydroxide or similar compounds to generate guanidine hydroxide in situ, marketed for lower scalp irritation compared to lye variants.^[17]^[143] These formulations aimed to achieve comparable straightening efficacy at slightly lower pH values (typically 11-13), though independent testing has confirmed persistent corrosivity to skin and hair follicles, with all tested products, including those for children, exceeding safe dermal thresholds.^[144] Recent peer-reviewed research has explored alternative active ingredients and reduced concentrations to mitigate damage. A 2024 study evaluated eight experimental straightening formulations on type 2 wavy hair, incorporating ammonium thioglycolate, amino methyl propanol thioglycolate, sodium cysteamine, and their combinations at varying strengths (1-13.3%), with pH ranges from 7.5-13.0. Lower-concentration variants (e.g., 4-7.9%) demonstrated reduced hair breakage, preserved mechanical resistance, and improved shine without compromising straightening, suggesting potential for tailored, less damaging applications, though efficacy on coarser, tightly coiled hair types remains unassessed in this work.^[145] Independent innovations include biochemist Marc Baum's patented acidic-pH (below 7) relaxer prototype, developed around 2023 at Oak Crest Institute, which employs amino acids, keratin proteins, and radish root-derived peptides to bypass alkaline hydrolysis and endocrine-disrupting additives like parabens and phthalates. While preclinical tests indicate reduced toxicity, the formulation awaits commercialization and lacks large-scale clinical validation for long-term safety or efficacy.^[146] Regulatory pressures have indirectly spurred formulation reforms by targeting specific hazards. The U.S. FDA's 2024 prohibition on formaldehyde and its releasers in hair straighteners addresses emissions of volatile carcinogens during application, prompting industry shifts away from such compounds in relaxer blends. Similarly, California's 2025 ban on formaldehyde, parabens, and phthalates in straightening products incentivizes hypoallergenic redesigns, though compliance data and post-reform health outcome studies are pending. Despite these advances, empirical evidence for substantially safer chemical relaxers remains preliminary, with no formulations yet demonstrating elimination of associated risks like shaft fragility or systemic absorption of irritants.^[146]^[113]

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The median pH of all relaxers (calcium hydroxide, lithium hydroxide and sodium hydroxide) was 12.36 (interquartile range 12.10 -12.62). The active ingredient ...
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The Difference Between Hair Texturizers and Relaxers - Byrdie
May 16, 2022 · Texturizers are applied when you don't want all of the curl removed from the hair. Instead, they loosen the natural curl pattern and can give the strands a ...
[54]
Relaxer vs Texturizer | Which Chemical Straightener Is Best For You?
Oct 27, 2024 · Unlike a relaxer, texturizers maintain some of your natural curls and kinks. Therefore, they are a great option for you if you love your curls ...
[55]
https://orshaircare.com/products/ors-olive-oil-mild-touch-relaxer
[56]
The Truth about Kiddie Relaxers and Textured Hair Damage
Strong hair relaxers aren't just bad for hair. Inhaling the product is toxic and unhealthy. Some relaxers can lead to endocrine disruption, irritation, and ...
[57]
MILADY Standard Barbering Chapter 17 Chemical Texture Services
A soft-curl permanent; combination of a thio relaxer and thio permanent, whereby the hair is wrapped on perm rods; used to make existing curl larger and looser.
[58]
[PDF] Relaxer Safety Tips - Milady
Caution! Sodium hydroxide and thio relaxers are chemically incompatible and can cause severe damage— even hair loss—when mixed or overlaid on the hair.Missing: efficacy | Show results with:efficacy
[59]
[PDF] Procedures for Chemical Hair Relaxing - FCT EMIS
o Apply petroleum jelly or a protective cream around the hairline, ears, and neck to prevent the relaxer from coming into contact with the skin. o Wear ...
[60]
Relaxer System Procedure on Virgin Hair - CHI Education
Use ¼” (6.35 mm) subsections and apply the relaxer thoroughly on both sides by using an application brush staying ½” away from scalp. DO NOT apply directly to ...
[61]
Type of Relaxers - AskMags.com
Hydroxide and Thio are the most common types of hair relaxers. Hydroxide relaxer types include sodium hydroxide, potassium hydroxide, lithium hydroxide and ...
[62]
Mechanism of No Lye vs Thio relaxers : r/relaxedhair - Reddit
Sep 2, 2025 · Both have a high ph to make hair swell up, both break open the cuticle, both breaks disulfide bonds and breaks keratin, both increase porosity - ...Missing: composition | Show results with:composition
[63]
Hair Cosmetics: An Overview - PMC - NIH
The roots need to be touch-up after 15–30 days and the product must be applied ... Chemical hair relaxers have adverse effects a myth or reality. Int J ...
[64]
How To Care For Relaxed Hair - Style Domination
Feb 7, 2019 · Relaxing requires hard work. Relax new growth every 8-10 weeks, trim dead ends, wash regularly, deep condition weekly, and moisturize daily.
[65]
Caring for Afro-textured hair - British Association of Dermatologists
Hair relaxers should be applied by a trained and experienced professional, who takes the special precautions detailed below. For touch-ups, relaxer should ...
[66]
Relaxed Hair Health: How to Care for Relaxed Hair All Year Round
2. Deep Conditioning ... Once a month, good. Once a week, even better! Maintain relaxed hair health by deep conditioning especially on your relaxer touch-up days.
[67]
Useful tips to grow and maintain your Relaxed Hair | Dark and Lovely
Stay hydrated, use neutralizing shampoo, deep condition, limit heat, use protective styling, and sleep with silk to maintain relaxed hair.<|separator|>
[68]
[PDF] An Examination of Food Terms in the Hair Industry and the Adverse ...
Apr 23, 2012 · Valerie Callender (2004:173) suggests, for black women with CCCA who chemically relax their hair, to decrease the frequency of touch-ups, have a ...
[69]
The Benefits and Challenges of Natural and Relaxed Hair
Apr 24, 2018 · 1) Relaxed hair is less prone to knotting and tangling on itself because the relaxing process removes majority of the kinks and bends in natural ...
[70]
5 Benefits of Relaxing Your Hair - PR at Partners
Relaxer removes the kinks and bends from natural hair that are responsible for tangles and knots. Your hair's new smoother texture means easier combing and less ...
[71]
Hair Relaxing- What Is It and What Are the Benefits - Martino Cartier
Jan 15, 2022 · Relaxing your hair saves time with daily straightening, stretching, and detangling. This means that it will shave hours off of your beauty ...
[72]
Relaxers 101: Everything You Need to Know About Hair Relaxers
Types of Hair Relaxers. There are two main types of hair relaxers: lye and no-lye relaxers. Each has its own benefits and considerations: Lye Relaxers.
[73]
Top Benefits Of Relaxing Curly Hair - Von Anthony Salon
Nov 27, 2022 · Relaxed hair stays straight and smooth despite high humidity or rainy weather. Faster, Easier Styling- No more hours of flat ironing every time you wash your ...<|separator|>
[74]
4 Benefits of Hair Relaxing Explained - Anna's Salon Elite
Feb 15, 2022 · Less Frizz Because of the smoothed cuticle and altered texture of relaxed hair, frizz will be nearly a thing of the past. With less frizz, you ...
[75]
Research Suggests Bias Against Natural Hair Limits Job ...
Aug 12, 2020 · Black women with natural hairstyles were perceived as less professional, less likely to get interviews. August 12, 2020.Missing: relaxed | Show results with:relaxed
[76]
https://journals.sagepub.com/doi/full/10.1177/1948550620937937
[77]
Black Hair Industry Statistics: Facts and Trends [2025] - Jobera
Jul 22, 2024 · Black women collectively spend around $1.7 billion annually on hair care items. 85% of African Americans use hair care products specifically ...
[78]
The Afro tax: African American women spend four times more on ...
Apr 13, 2023 · African American women spend the most on hair care each month, with 21 percent spending more than 25 percent of their monthly budget on hair ...
[79]
Minority hair tax: pricing bias in haircare products - PubMed Central
Black haircare is an estimated $2.51-billion-dollar industry. Black women spend 9 times more on ethnic hair products than non-Black consumers.
[80]
'Relaxers' damage hair: Evidence from amino acid analysis
A recent study reported relaxed hair lengths much shorter than expected, suggesting increased fragility; the potential for scalp inflammation and scarring ...<|separator|>
[81]
Chemical Hair Relaxers Have Adverse Effects a Myth or Reality - PMC
It has been stated that long term use of such products can be harmful as it is believed to enter the scalp through scalp lesions and burns.[6] A case report ...Missing: efficacy | Show results with:efficacy
[82]
[PDF] Chemical relaxers and curlers: Hidden danger
The commonest adverse events associated with the use of chemical hair relaxers were hair loss (61%), dry hair (45%), dandruff (20%), thinning of hair (30%), ...
[83]
Safety of chemical hair relaxers: A review article
Sep 10, 2024 · No-lye relaxers contain calcium, guanidine, or lithium hydroxide, which also break disulfide bonds but cause less scalp irritation. ...
[84]
Hair Relaxer Use and Risk of Uterine Leiomyomata in African ...
Jan 10, 2012 · The frequency of hair relaxer use ranged from as low as 8.6% for 1–2 times per year to as high as 32.6% for ≥7 times per year.
[85]
Frequent use of chemical hair straighteners and relaxers is ...
Sep 15, 2023 · These hair products contain a number of chemicals that may act as carcinogens or endocrine disruptors and thus may be important for cancer risk.
[86]
Use of Straighteners and Other Hair Products and Incident Uterine ...
Oct 17, 2022 · Previous studies have found hair product use to be associated with a higher risk of hormone-sensitive cancers including breast and ovarian ...
[87]
Hair Straightening Chemicals Associated With Higher Uterine ...
Women who used chemical hair straightening products were at higher risk for uterine cancer compared to women who did not report using these products.
[88]
Study: Hair Relaxers Linked To Breast Cancer Risk
Aug 6, 2021 · Evidence from animal and other experimental studies support a possible link between chemicals included in hair relaxers and cancer development.<|separator|>
[89]
Systematic Review of the Epidemiology of Hair Relaxer Use and ...
Jan 19, 2025 · Hair relaxers are predominantly used by Black women in the United States. It has been recently suggested that exposure to potential ...
[90]
Uncovering the dangers of hair products marketed to Black women ...
Jun 15, 2024 · “At some point you have evidence enough to start making recommendations that people reduce their use of these products or don't use them at all.
[91]
Systematic Review of the Epidemiology of Hair Relaxer Use and ...
Jan 19, 2025 · One study found a statistically significant association between hair relaxer use and uterine leiomyomata, but there were no other studies ...
[92]
[PDF] Evidence Scan: Hair relaxers and cancer | ACT Center
A few high-quality studies have demonstrated associations between hair relaxer use and ovarian and uterine cancers. However, research to date has produced ...
[93]
A systematic review of association between use of hair products and ...
Chang et al. reported strong association between uterine cancer risk and hair relaxer use (HR 1.8, 95 % CI: 1.12–2.88), with no observed association with hair ...<|separator|>
[94]
Hair Straightener Use in Relation to Prevalent and Incident Fibroids ...
Jan 14, 2025 · We examined the association between straightener use and prevalent young-onset uterine fibroids (diagnosed before age 36 y), as well as incident fibroids.
[95]
Use of Hair Straighteners/Chemical Relaxers and Incidence of Non ...
Sep 30, 2025 · Use of hair straighteners and chemical relaxers has been associated with increased incidence of breast, uterine, and ovarian cancers.
[96]
Measurement of endocrine disrupting and asthma-associated ...
This preliminary study investigates the endocrine disrupting and asthma-associated chemical content of hair products used by US Black women.
[97]
Use of straighteners and other hair products and incident uterine ...
First, the adjusted hazard ratio for the risk of uterine cancer was stated as 2.78 (95% confidence interval = 1.39 to 5.55), which was based on 14 cases (see ...Missing: relaxer | Show results with:relaxer
[98]
Studies Link Hair Relaxers To Cancer. Many Doctors Question The ...
Jul 8, 2024 · Postmenopausal uterine cancer women who used relaxers more than twice a year or for more than five years had more than a 50% increase in risk of uterine cancer.
[99]
Hair dye and chemical straightener use and breast cancer risk in a ...
Many hair products contain endocrine disrupting compounds and carcinogens potentially relevant to breast cancer. Products used predominately by black women ...<|control11|><|separator|>
[100]
Study: Women Using Hair Relaxers Face 2x Cancer Risk
Nov 1, 2022 · Of the women who were studied, 1.64 percent who never used hair straightening products eventually developed uterine cancer by age 70. However, ...
[101]
Thousands of Black women claim hair relaxers gave them cancer
Nov 4, 2023 · Bush filed a lawsuit against cosmetic companies after a study showed an association between hair relaxers and uterine cancer risk.<|separator|>
[102]
Hair Relaxer Lawsuit Settlement | October 2025 Update
Oct 2, 2025 · Plaintiffs will present their experts in the morning, laying out the research that links chemical hair relaxers to uterine cancer, fibroids, and ...
[103]
L'Oreal Dark & Lovely Lawsuit
Feb 5, 2025 · These lawsuits allege that L'Oréal's popular hair relaxer product, Dark & Lovely, caused uterine cancer and other injuries.
[104]
Olive Oil Relaxer Lawsuit | Product Risks - Motley Rice
ORS Olive Oil hair relaxer may come with dangerous health risks. These products are alleged to contain toxic chemicals, including EDCs, which can block hormone ...
[105]
The Truth About Hair Relaxers: In the US, Lawsuits Over Cancer. In ...
Apr 10, 2024 · Last year, Procter and Gamble bought Mielle Organics, a black-owned natural haircare company. ... Nearly 60 Hair Relaxer Lawsuits Against L ...<|separator|>
[106]
L'Oréal Uterine Cancer Lawsuit - Meirowitz & Wasserberg, LLP
Plaintiff Jenny Mitchell filed a lawsuit against L'Oréal and other hair care companies, arguing that their hair relaxer products caused her to develop uterine ...<|separator|>
[107]
Federal Judge Rejects Motion to Dismiss from Defendants in ...
Nov 16, 2023 · The court ruling resulted in the rejection of plaintiffs' fraud charges and the dismissal of two international defendants, it preserved the bulk of the ...Missing: Procter | Show results with:Procter
[108]
Hair Relaxer Uterine Cancer Settlement Amounts - Oberheiden P.C.
However, current estimates put most potential hair relaxer uterine cancer lawsuit settlements somewhere in the range of $100,000 and $2 million.
[109]
HAIR RELAXER LAWSUIT | October 2025 Update - Miller & Zois
If the evidence linking chemical hair relaxers to uterine cancer holds up, we believe the average settlement for a strong case could be in the $300,000 range.
[110]
Hair Relaxer Lawsuit & Settlement | October 2025 Update
The Georgia Supreme Court is allowing a hair relaxer lawsuit involving Strength of Nature and L'Oréal to move forward. This overturns a ruling by a lower court ...
[111]
Hair Relaxers and Uterine Cancer - Lieff Cabraser
Aug 29, 2025 · The FDA is planning to propose a ban on hair relaxer products that have been linked in scientific studies to ovarian and uterine cancer in long-term users.
[112]
Hair Relaxer Class Action Suits: the next round of Monsanto-style ...
Sep 2, 2025 · These suits allege that the hair relaxer products contain toxic chemicals which have increased the risk of health problems such as ovarian and/ ...
[113]
Proposed Rule - View Rule
This proposed rule would ban formaldehyde (FA) and other FA-releasing chemicals (e.g., methylene glycol) as an ingredient in hair smoothing or hair ...
[114]
Hair Smoothing Products That Release Formaldehyde When Heated
Oct 15, 2024 · OSHA issued a Hazard Alert to hair salon owners and workers about potential formaldehyde exposure from working with these hair smoothing ...Missing: lawsuits | Show results with:lawsuits
[115]
Hair Dye and Hair Relaxers - FDA
Jun 27, 2022 · FDA does monitor the safety of hair dyes and relaxers. Tell FDA if you have itchy or raw skin, scabs, hair loss or other problems after using ...
[116]
Federal regulations paused, halting FDA's proposed ban on ...
Jan 22, 2025 · A proposal to ban formaldehyde in hair straightening products is now in limbo after President Donald Trump signed an executive order pausing all federal ...
[117]
FDA's plan to propose ban on formaldehyde in hair-straightening ...
Feb 11, 2025 · FDA's plan to propose ban on formaldehyde in hair-straightening products remains in limbo under Trump administration. Chemicals in certain hair ...
[118]
[PDF] April 9, 2025 The Honorable Marty Makary Commissioner U.S. Food ...
Apr 9, 2025 · We write to inquire about the status of the proposed ban on formaldehyde in hair products, which was issued in. October 2023 due to alarming ...
[119]
L'Oreal Statement in Response to Hair Straightening Product ...
Nov 17, 2023 · We are confident in the safety of SoftSheen-Carson's products and believe the allegations made in these lawsuits have neither legal nor scientific merit.
[120]
FDA Move to Ban Hair Relaxer Chemical Called Too Little, Too Late
Feb 7, 2024 · California and Maryland will ban formaldehyde from all personal-care products starting next year. And manufacturers already have curtailed their ...
[121]
FDA's delayed action on formaldehyde ban in hair relaxers sparks ...
Sep 11, 2024 · While the timeline remains uncertain, Stevenson expects that the FDA will eventually regulate formaldehyde in hair relaxers, though the extent ...<|separator|>
[122]
[PDF] A Historical Review of Hair in US White-Black Race Relations and ...
1950s –Chemical lye-based hair treatments were introduced to conveniently offer longer-lasting straightening of curly hair types. Civil Rights Era- Afros ...
[123]
Hair Alteration Practices Amongst Black Women and the Assumption ...
Black women alter their naturally 'kinky' or 'nappy' hair because they want to distance themselves from an African heritage to appear White.
[124]
https://journals.sagepub.com/doi/10.1177/00957984231191849
[125]
It's More Than “Just” Hair: Revitalization of Black Identity
Nov 7, 2022 · With the growing popularity of these straightened styles, definitions for what was deemed “good Black hair” and “bad Black hair” emerged. “ ...
[126]
The Person Beneath the Hair: Hair Discrimination, Health, and Well ...
Aug 2, 2023 · The Black Power Movement discouraged its followers against hair straightening and encouraged Afrocentric styles.
[127]
First Large Study of Hair Relaxers Among Black Women Finds ...
Oct 11, 2023 · Our study suggests that moderate and heavy use of chemical hair relaxers may be associated with higher risk of uterine cancer among postmenopausal Black women.
[128]
Black women seek alternatives to chemical hair relaxers | 10tv.com
Mar 12, 2025 · Concerns about health risks, including links to gynecological tumors and uterine cancer, are driving a shift in Black hair care away from chemical relaxers.
[129]
While many Black women in US abandon hair relaxers linked to ...
Apr 10, 2024 · While many Black women in US abandon hair relaxers linked to cancer, sales climb in African countries ... “People still use hair relaxers as much ...Missing: race | Show results with:race
[130]
Why Some Black Women Are Going Back to Relaxers - Allure
Jul 21, 2021 · Although recent data has shown relaxer purchases are still on a steep decline, there is a cohort of women who are bucking the natural hair trend ...
[131]
Exploring the Growing Use of Hair Relaxers Amid Health Concerns
Jun 30, 2024 · The hair relaxer market, valued at $717.06 million today, is projected to grow to $839.1 million by 2029. For context, its value in 2013 was $152 million.
[132]
How Hair Discrimination Affects Black Women at Work
May 10, 2023 · Black women's hair was two-and-a-half times more likely to be perceived as unprofessional. More than half of the Black women surveyed felt like ...
[133]
Booker, Collins Reintroduce Bipartisan CROWN Act to Ban Hair ...
Feb 26, 2025 · The CROWN Act provides explicit protection against racial discrimination based on natural and protective hairstyles associated with African ...
[134]
Hair Discrimination FAQ - Legal Defense Fund
The study determined that Black women with natural hairstyles are less likely to land job interviews than white women or Black women with straightened hair.
[135]
Hair Maintenance and Chemical Hair Product Usage as Barriers to ...
Dec 10, 2020 · In adulthood, ≥twice/year chemical relaxer users (30%) were less likely (PR = 0.90 [95% CI: 0.79–1.02]) and ≥once/week leave-in conditioner ...
[136]
Why some Black women won't or can't quit hair relaxers
Dec 13, 2022 · Studies show the products may double the risk of uterine cancer, but tradition, societal pressure and personal taste create obstacles to change.
[137]
Straight to the Point: What Do We Know So Far on Hair Straightening?
Mar 30, 2021 · Their mechanism of action is similar to other acid straighteners: besides the already known formation of cross-links involving 2 or more ...
[138]
https://www.ewg.org/hair-straighteners/our-report/how-to-get-straight-hair-whats-the-best-option/
[139]
The Safest, Non-Toxic Options to Straighten Textured Hair
Dec 27, 2023 · Heat styling is the only guaranteed non-toxic approach to straightening that has no potential for long-term damage to your hair. Even gentler ...
[140]
How to Straighten Hair: 7 Heat-Free Tips for Straight Hair - Healthline
May 22, 2018 · Tips for getting straight hair without using heat · 1. Blow dry with cold air · 2. Wrap your hair · 3. Roll with plastic rollers · 4. Use products ...
[141]
Straightening Textured Hair: Considerations for Children & Teens
Jun 13, 2024 · How to straighten hair: 3 basics techniques · 1. Stretching hair with ribbons, threads, braids & twists · 2. Heating hair with styling tools · 3.Missing: non- evidence-
[142]
Safe alternatives for hair straightening without chemicals | 11alive.com
Apr 8, 2025 · Consumer Reports looked into some chemical-free alternatives that may help achieve similar results without the health risks.
[143]
Gentle Treatment No-Lye Relaxers vs. - Samuel's Science
Dec 27, 2024 · No-lye relaxers use calcium hydroxide and guanidine carbonate instead of sodium hydroxide (lye). This formulation reduces scalp irritation while effectively ...
[144]
Hair relaxers tested by UCT lab found to be corrosive to skin
Mar 9, 2020 · Relaxing hair over time can leave the hair follicles completely damaged because the compounds used cause inflammation of the scalp. Continuous ...
[145]
Comparative Assessments of New Hair-Straightening Cosmetic ...
In this research, we compared eight hair-straightening formulations with different active ingredients and/or concentrations to develop new, safer and more ...
[146]
Hair Straighteners and Relaxers May Be Harmful to Health. Here's ...
Nov 14, 2023 · The scalp burns and unpleasant smells of lye-based hair relaxers, along with growing evidence of cancer risks, have led stylists and ...

Relaxer

Overview

Definition and Chemical Mechanism

Prevalence and Demographics

Historical Development

Origins in the Early 20th Century

Post-WWII Commercialization and Industry Growth

Chemical Types and Formulations

Thio Relaxers

Alkaline Relaxers

Lye-Based Relaxers

No-Lye Relaxers

Specialized Variants

Usage and Application

Application Procedures

Maintenance and Regrowth Management

Purported Benefits

Practical and Aesthetic Advantages

Socioeconomic and Professional Impacts

Health Risks and Scientific Evidence

Local Effects on Hair and Scalp

Systemic Health Associations

Links to Reproductive Cancers

Other Potential Correlations

Links to Reproductive Cancers

Other Potential Correlations

Empirical Critiques and Confounding Factors

Legal and Regulatory Landscape

Product Liability Litigation

FDA Warnings and Industry Responses

Cultural and Social Dimensions

Relaxation Practices in Black Communities

Debates on Natural Hair Versus Chemical Straightening

Alternatives and Future Directions

Non-Chemical Straightening Methods

Research into Safer Formulations

References