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Cone snail

Cone snails are venomous predatory marine gastropods belonging to the family Conidae, renowned for their distinctive cone-shaped shells and sophisticated venom delivery systems.^[1] These snails, primarily in the genus Conus, comprise approximately 850 extant species that inhabit tropical and subtropical ocean waters worldwide, often in shallow coastal environments such as coral reefs, sandy flats, and seagrass beds, though some dwell at depths up to several hundred meters.^[2]^[3]^[4] As active hunters, cone snails employ a extendable proboscis to deploy a harpoon-like radular tooth that injects a complex venom cocktail known as conotoxins, which are disulfide-rich peptides targeting ion channels, receptors, and transporters to paralyze prey.^[5] Their diet varies by species and evolutionary lineage: vermivorous types primarily consume polychaete worms, molluscivorous ones prey on other gastropods, and piscivorous species hunt fish, with the latter often possessing the most potent venoms.^[4] This specialized predation has driven remarkable venom diversity, with each species producing hundreds of unique conotoxins tailored to their ecological niche.^[1] While most encounters with humans are harmless, stings from certain piscivorous cone snails can cause severe envenomation, including paralysis and, in rare cases, death, due to the neurotoxic effects of their venom.^[3] Conversely, the pharmacological potential of conotoxins has led to significant biomedical applications; for instance, ziconotide, derived from the venom of Conus magus, is an FDA-approved analgesic for chronic pain.^[1] Conservation efforts highlight threats from habitat loss and shell collection, underscoring the need to protect this biodiverse group.^[6]

Description and anatomy

Shell

The shells of cone snails exhibit an elongated, conical shape, typically forming an inverted cone with a narrow anterior end, a long and slender aperture, and a short siphonal canal.^[5] These dimensions allow for efficient retraction of the soft body while maintaining a streamlined profile. Shell lengths vary widely among species, generally ranging from 10 to 230 mm.^[3] Surface features of cone snail shells include axial ribs, nodules, and spiral ridges that contribute to structural reinforcement and visual distinction.^[7] Intricate color patterns, often featuring bands, spots, or mottling in shades of brown, yellow, and white, provide camouflage against sandy or coral substrates and assist in species identification.^[8] The shell's material composition consists primarily of calcium carbonate in the aragonite polymorph, arranged in a crossed-lamellar microstructure of rod-shaped crystals that enhances toughness and fracture resistance.^[9] An outer periostracum layer, composed of organic proteins, covers the shell and offers initial protection against environmental abrasion.^[10] These shells serve adaptive roles in predator protection, with their robust, layered structure deterring crushing by larger marine animals such as octopuses or fish.^[11] Additionally, the shell provides structural support, anchoring muscles that enable the projection of the radula during feeding.^[12] Variations in shell morphology occur across species, with some displaying smooth surfaces and others featuring pronounced sculpturing like ribs or tubercles.^[7] Color morphs are more vibrant and diverse in tropical species, aiding camouflage in coral reefs, while temperate species tend toward subdued patterns better suited to cooler, sediment-rich environments.^[13] Shell morphology also plays a crucial role in taxonomic classification, as differences in shape, ornamentation, and patterning help delineate species boundaries.^[14]

Radula and harpoon

In cone snails, the radula has undergone significant modification compared to the typical gastropod structure, which consists of a flexible membrane bearing multiple rows of chitinous teeth arranged in transverse series for scraping or cutting food. Instead, the Conus radula is reduced to a single tooth per row, forming a specialized, hollow, harpoon-like structure that serves as the primary tool for prey capture. This single tooth, known as the radular harpoon, is barbed to anchor into the prey and features a central canal that allows for envenomation upon deployment.^[15] The harpoon tooth exhibits a distinct tripartite morphology consisting of a bulbous base, a narrow shaft, and a bladed tip equipped with backward-facing barbs. The bulbous base attaches to the proboscis for loading and propulsion, the hollow shaft provides structural support and serves as a conduit for venom delivery, and the bladed tip facilitates penetration and securement of the prey. This design enables the harpoon to function like a hypodermic needle, piercing tissues to inject venom directly. The harpoon integrates with the venom apparatus by drawing fluid from the venom bulb through its hollow core during projection.^[16]^[17] Projection of the harpoon occurs via a hydrostatic mechanism, where pressurized fluid from the venom bulb builds within the extended proboscis, engaging a cellular latch at the harpoon base until release. Upon prey contact, the latch disengages, propelling the harpoon forward at peak velocities averaging 19.3 m/s and exceeding 25 m/s in fish-hunting species, with average peak accelerations exceeding 280,000 m/s² (approximately 28,600 g) and maximal accelerations over 400,000 m/s² (about 40,800 g). This rapid deployment represents an evolutionary adaptation for overcoming the escape responses of mobile prey like fish.^[18]^[15] Evolutionarily, the Conus radula's specialization as a disposable, single-use harpoon reflects adaptations from ancestral worm-hunting forms, with piscivorous lineages independently evolving enhanced barbs and speed for tethering larger prey. Each harpoon is expended after use—often regurgitated shortly thereafter—and the radular sac continuously produces replacements, regenerating a new tooth within days to maintain readiness for subsequent hunts. This disposable nature contrasts sharply with the multi-tooth, reusable radulae of other gastropods, underscoring the Conidae's shift toward venom-mediated predation.^[15]^[19]

Venom apparatus

The venom apparatus of cone snails comprises an unpaired venom gland, a venom duct, and a muscular bulb. The venom gland is a long, highly convoluted structure extending from the posterior end of the animal, lined with glandular epithelium responsible for toxin synthesis, and connected to the pharynx via the duct. The duct facilitates the transport of venom components, while the muscular bulb at the proximal end of the gland serves for venom storage and generates hydrostatic pressure to propel the venom during injection.^[20] Cone snail venom consists of a complex mixture of 50 to 200 conotoxins per species, primarily small disulfide-rich peptides known as conopeptides that target specific neuronal components. These include alpha-conotoxins, which antagonize nicotinic acetylcholine receptors; omega-conotoxins, which block N-type voltage-gated calcium channels; and mu-conotoxins, which inhibit voltage-gated sodium channels, among other families.^[20]^[21]^[22] Conotoxins are produced through the synthesis of precursor proteins in the glandular epithelium of the venom gland, where they undergo post-translational processing, including disulfide bond formation and proteolytic cleavage. Genetic diversity arises from hypermutation in conotoxin-encoding genes, enabling rapid evolution and species-specific variations in peptide sequences and structures.^[23]^[20] Venom composition exhibits significant variability across cone snail species, tailored to their dietary preferences: approximately 70% of species are vermivores with venoms optimized for immobilizing polychaete worms, 15% are molluscivores targeting other gastropods, and 15% are piscivores adapted for capturing fish. This prey-specific adaptation ensures efficient envenomation strategies distinct from those in other clades.^[20] The evolutionary refinement of conotoxins over millions of years has positioned them as valuable models for drug discovery, owing to their precise targeting of ion channels and receptors honed by natural selection for prey capture.^[23]

Habitat and ecology

Distribution

Cone snails are predominantly distributed in tropical and subtropical marine waters worldwide, exhibiting their highest species diversity in the Indo-Pacific region, where the majority of the over 850 described species occur.^[24] This region accounts for approximately 60% of known cone snail diversity, spanning vast coral reef systems from the Red Sea in the west to French Polynesia in the east.^[25] In contrast, species richness is considerably lower in the Atlantic Ocean and eastern Pacific, with around 98 species documented in the eastern Atlantic and even fewer in the western Atlantic and eastern Pacific regions.^[26] These gastropods occupy a wide bathymetric range, from shallow intertidal zones to depths exceeding 700 meters, though most species prefer shallow waters less than 50 meters deep. Deep-water species, particularly those in genera such as Profundiconus, extend this range further, with records from collections reaching up to 1,260 meters in areas like New Caledonia's Exclusive Economic Zone.^[27]^[28] Endemism is a prominent feature of cone snail distribution, with numerous species confined to specific islands or archipelagos due to biogeographic isolation. For instance, the Cape Verde Islands host 55 species, 52 of which are endemic (noting one recent extinction as of 2025), highlighting hotspots of localized diversity in the eastern Atlantic.^[29] Similarly, many Indo-Pacific islands support unique assemblages, contributing to the overall pattern of restricted ranges observed in about 37.5% of species with areas of occupancy under 100 km².^[25]^[27] Limited larval dispersal plays a key role in shaping these distribution patterns, as most cone snails produce planktotrophic larvae that, despite enabling some oceanic transport, often result in gene flow constrained by oceanographic barriers and developmental constraints. This contributes to low migration rates across major biogeographic divides, such as those separating the Indo-Pacific from the Atlantic and eastern Pacific.^[30]

Preferred environments

Cone snails, genus Conus, predominantly occupy tropical and subtropical marine habitats, with a strong preference for coral reefs where they achieve the highest species diversity and abundance. They also inhabit sandy or muddy bottoms, seagrass beds, and mangrove fringes, often in shallow coastal waters from the intertidal zone to depths of around 50 meters. These environments provide the structural complexity and prey availability essential for their predatory lifestyle.^[31]^[27]^[13] Within these habitats, cone snails exploit diverse microhabitats, such as burrowing partially or fully into loose sediment on reef flats or lagoon floors to remain concealed during daylight hours, or attaching to rocks, coral rubble, and sponges for stability. Many species are nocturnal, emerging at night to forage while retreating to protective crevices, algal mats, or under overhangs during the day to avoid predators and desiccation in intertidal areas. For instance, species like Conus geographus frequently burrow in sand near reefs, enhancing their ambush capabilities.^[31]^[32]^[33] Cone snails exhibit environmental tolerances suited to stable tropical conditions, typically thriving in seawater salinities of 30–35 ppt and temperatures ranging from 20–30°C, though some species can endure broader fluctuations such as salinities from 5–40 ppt under optimal temperatures around 20°C. Certain deep-water or sediment-dwelling species show adaptations to lower oxygen levels, such as in hypoxic burrow environments or deeper reef slopes. These tolerances reflect their reliance on consistent Indo-Pacific and Atlantic coastal ecosystems.^[34]^[35]^[27] Adaptations to these environments include intricate shell coloration and patterning that provide camouflage against sandy, rubbly, or coral backgrounds, allowing the snails to blend seamlessly with their surroundings for predatory ambushes. Burrowing behaviors, facilitated by a muscular foot, enable them to create temporary shelters in sediment while maintaining sensory awareness through extended siphons. Such traits are particularly evident in reef-associated species, where shell patterns mimic surrounding algae or rubble.^[8]^[13]^[36] Habitat change poses acute risks to cone snails, particularly those reliant on coral reefs, where bleaching events driven by rising sea temperatures and ocean acidification degrade structural habitats and reduce microhabitat availability. For example, widespread coral mortality has led to population declines in reef-dependent species across the Indo-Pacific, disrupting their preferred niches.^[27]^[35]

Feeding behavior

Cone snails are classified into three primary dietary guilds based on their prey preferences: piscivorous species that primarily hunt fish, molluscivorous species that target other mollusks such as other snails, and vermivorous species that feed on polychaete worms and similar invertebrates.^[37] This specialization influences their venom composition and hunting efficiency, with piscivorous species generally exhibiting the most potent and rapid-acting toxins to subdue fast-moving fish.^[23] For instance, species like Conus geographus and Conus textile are piscivorous and rely on fish as their main prey.^[38] Hunting strategies among cone snails emphasize stealth and precision, often involving ambush predation where the snail remains camouflaged on the substrate until prey approaches within striking distance.^[39] Piscivorous species frequently employ a lightning strike technique, rapidly everting the proboscis—up to 20 times their body length in milliseconds—to impale the prey with a harpoon-like radular tooth.^[40] Alternatively, some utilize a "net-hunting" or "cabling" strategy, extending the proboscis in a lasso-like manner to ensnare and tether fish before envenomation, as observed in species like Conus catus.^[41] Vermivorous and molluscivorous species tend toward slower, more deliberate approaches, such as probing sediments or luring prey with protrusible structures mimicking food or mates.^[42] The envenomation process is initiated by the harpoon strike, which injects a complex mixture of conotoxins through the venom apparatus, leading to near-instantaneous paralysis—often within 2-5 seconds for fish prey—by disrupting neuromuscular transmission and ion channels.^[43] Following immobilization, external digestive enzymes are sometimes released to begin liquefying the prey's tissues externally, facilitating consumption.^[44] The entire prey is then engulfed whole via the highly extensible proboscis and mouth, with ongoing toxin effects preventing any post-capture resistance; indigestible remnants, such as shells or exoskeletons, are expelled hours later.^[45] Behavioral variations in feeding reflect ecological adaptations, with many species exhibiting nocturnal foraging to exploit crepuscular prey activity, though some temperate piscivores like Conus californicus hunt diurnally in response to fish availability.^[44] Active foraging involves siphon-mediated prey detection and pursuit over short distances, contrasting with passive ambush tactics where snails position themselves in high-traffic prey areas and wait.^[46] These patterns can shift ontogenetically, as seen in Conus magus, where juveniles are strictly vermivorous with cautious probing behaviors before transitioning to piscivory in adulthood via bolder strikes.^[47]

Evolutionary history

Paleontology

The fossil record of cone snails (genus Conus) dates back to the early Eocene epoch, approximately 55 million years ago, when primitive Conus-like forms first appeared in shallow marine deposits across what is now Europe. These earliest known fossils, including species such as Eoconus edwardsi (Hampshire Basin) and E. deperditus (Paris Basin), have been recovered from Lower Eocene sediments in the Paris Basin of France and the Hampshire Basin of southern England, indicating an origin in temperate to subtropical shelf environments during a period of global warming following the Paleocene-Eocene Thermal Maximum.^[27]^[48] Fossil diversity expanded significantly through the Cenozoic, with over 1,000 described extinct species documented to date, though many may represent synonyms due to similarities in shell morphology. Diversity peaked during the Miocene epoch (23–5 million years ago), a time of rapid speciation and geographic radiation coinciding with the expansion of tropical shallow-water habitats and the closure of the Tethys Sea, which facilitated dispersal into the Indo-Pacific and Atlantic regions. Key fossil assemblages from this period include those from Neogene coral reef deposits in the Dominican Republic, where well-preserved shells reveal insights into coloration patterns and ecological roles, and Miocene chalk and limestone formations in Europe, such as those in Crete and the Mediterranean Basin.^[49]^[50]^[4] Morphological evolution in the fossil record reflects adaptations to predatory lifestyles, with shell coiling transitioning from loosely coiled, more globose forms in Eocene ancestors to the tightly coiled, elongated conical shapes characteristic of later species, enhancing mobility and camouflage in reef environments. Concurrently, the radula underwent specialization, evolving from a multi-tooth configuration typical of ancestral vermivorous neogastropods to the single, hypodermic harpoon-like tooth seen in modern molluscivorous and piscivorous Conus, enabling precise venom delivery for prey capture. These changes are evident in comparative analyses of radular remnants and shell microstructures from Miocene and Pliocene sites.^[51] Significant extinctions occurred during the Pleistocene epoch (2.6 million–11,700 years ago), driven by repeated glacio-eustatic sea-level fluctuations that contracted shallow tropical habitats, particularly affecting island-endemic and reef-associated species in the western Atlantic and Caribbean. Fossil evidence from Plio-Pleistocene deposits shows a decline in species richness and average body size among surviving lineages, with approximately 70% of regional Conus diversity lost in the western Atlantic due to habitat fragmentation and reduced nutrient availability.^[52]

Phylogenetic relationships

Cone snails, belonging to the family Conidae, are placed within the superfamily Conoidea of the order Neogastropoda, formerly grouped under the toxoglossan gastropods.^[53] This positioning reflects their shared characteristics with other venomous marine gastropods, including a harpoon-like radula for prey envenomation.^[54] Within Conoidea, molecular phylogenies indicate that Conidae is monophyletic and forms a distinct lineage, with some analyses suggesting a close relationship to Terebridae (auger snails) as part of a broader diversification of toxiferous families.^[55] The family underwent significant diversification approximately 50 million years ago during the Eocene, coinciding with the radiation of Neogastropoda and the evolution of complex venom systems.^[56] Large-scale molecular studies, incorporating mitochondrial DNA (e.g., COI gene) and nuclear markers (e.g., 28S rRNA and histone H3), reveal a rapid radiation of Conidae primarily in the Indo-Pacific region, the ancestral cradle of the group.^[57] This phylogeny, based on over 300 species, identifies four major highly divergent clades (Clades A–D), with limited subsequent dispersal to other oceans, underscoring the Indo-Pacific's role in driving speciation through ecological opportunities like diverse prey availability.^[58] Phylogenetic analyses further delineate key clades by dietary specialization, separating piscivorous (fish-hunting) lineages from non-piscivorous ones (e.g., vermivorous or molluscivorous). Piscivory has arisen independently at least three times, in distinct subclades such as those including Conus geographus and Conus tulipa, highlighting convergent evolution in venom composition and hunting strategies.^[59] Non-piscivorous clades, often basal, retain ancestral worm- or mollusk-hunting behaviors, with transitions to fish predation linked to innovations in conotoxin diversity.^[60] The monophyly of Conus sensu lato has been challenged by these molecular data, which demonstrate paraphyly within the traditional genus, prompting a 2014 reclassification that recognizes multiple genera across the four clades to better reflect evolutionary relationships.^[61] This shift emphasizes the polyphyletic nature of shell-based taxonomy and advocates for integrating genetic evidence in Conidae systematics.

Life history

Reproduction

Cone snails are gonochoristic, possessing separate sexes with distinct males and females.^[62] Internal fertilization occurs during copulation, in which the male mounts the female using its foot and inserts a ribbon-like verge—analogous to a penis—into the female's mantle cavity opening to transfer sperm.^[33] Mating is facilitated by chemical cues, as individuals secrete pheromones to attract potential partners; the male then approaches the female, and copulation may last several hours depending on the species.^[31] Following fertilization, females deposit eggs in gelatinous capsules attached to hard substrates such as rocks or coral, often in clusters to protect against environmental hazards. Each capsule typically contains dozens to hundreds of eggs, with species like Conus geographus producing about 40 eggs per capsule in masses of multiple capsules, while others may yield up to 1,000 eggs per capsule across 20–50 capsules per mass.^[33] Within these capsules, embryos develop either into free-swimming veliger larvae, which hatch and enter the plankton, or directly into juvenile snails via intracapsular metamorphosis, depending on the species' life history strategy. Cone snails exhibit no parental care after egg deposition; females abandon the capsules, relying on high fecundity—often thousands of eggs per reproductive event—to offset high rates of predation and mortality in early life stages.^[31] Sexual dimorphism is minimal across the genus, with males and females generally similar in shell shape, color, and size, though some species show slight differences in maximum adult size, such as females growing marginally larger in certain vermivorous taxa.^[31]

Development and growth

Cone snails display two primary larval developmental modes: planktotrophic veligers, which are free-swimming larvae that actively feed on plankton to fuel their growth, and lecithotrophic larvae, which are non-feeding and depend on internal yolk reserves for energy during their brief pelagic phase.^[63] Most species in the genus Conus employ planktotrophic development, allowing larvae to sustain longer planktonic periods, whereas lecithotrophic development occurs in select species, such as those endemic to the Cape Verde archipelago, where larvae derive nourishment from an egg sac without external feeding.^[64] In planktotrophic species, veliger larvae can disperse for 10 to 50 days—or up to several weeks to months in natural conditions—via ocean currents, facilitating the wide geographic distribution observed across tropical and subtropical marine environments.^[65] This pelagic phase ends with settlement onto appropriate substrates, such as sandy or coralline bottoms, triggering metamorphosis; during this process, the velum (a larval swimming organ) regresses, the operculum forms, and the protoconch transitions into the adult teleoconch shell, marking the onset of benthic life.^[66] Following metamorphosis, juvenile cone snails exhibit steady shell growth, typically at rates of 1 to 2 mm per month in shallow-water species like Conus pennaceus, though variability exists across taxa due to environmental factors such as temperature and food availability.^[67] Sexual maturity is generally attained within 1 to 3 years, with smaller species reaching reproductive size sooner (e.g., 6 to 12 months in Conus geographus) compared to larger forms.^[33] Lifespans range from 5 to 20 years, influenced by habitat; deep-water species often display slower growth rates and extended longevity owing to lower metabolic demands in cooler, stable environments.^[20]

Taxonomy and classification

Current taxonomy

The family Conidae comprises over 1,000 extant species of cone snails, classified into 8 accepted genera and numerous subgenera following updates to the 2015 taxonomic revision.^[68] This revision, building on a comprehensive molecular phylogeny, restructured the traditional broad genus Conus sensu lato to reflect evolutionary relationships more accurately.^[69] The current system, as endorsed by the World Register of Marine Species (WoRMS) as of 2025, recognizes the family Conidae with 8 genera: Californiconus, Conasprella, Conus, Kenyonia, Lilliconus, Profundiconus, Pseudolilliconus, and Pygmaeconus, along with many subgenera.^[68] For instance, Conus includes well-known subgroups like the textile cones (Conus textile and relatives), while Conasprella, Profundiconus, and others represent distinct lineages adapted to varied habitats, such as deep-water environments in the latter.^[69] This framework has evolved from the 803 valid species recognized in 2015, with subsequent additions and reclassifications bringing the total over 1,000.^[69] The classification criteria integrate molecular data from mitochondrial genes, including cytochrome c oxidase subunit I (COI), 16S rRNA, and 12S rRNA, analyzed across 329 species, with supporting morphological evidence from shell morphology and radular dentition.^[57] These approaches revealed four major divergent clades initially, but subsequent studies have justified further separations into additional genera.^[57] Post-2015 updates have included descriptions of new deep-water species and taxonomic adjustments, such as the 2023 review of New Caledonian fauna that described one new species (Conus samadiae) but preserved the overall structure while noting ongoing refinements.^[28] As of November 2025, the system continues to evolve, with WoRMS reflecting the latest accepted genera.^[68]

Historical developments

The genus Conus was established by Carl Linnaeus in his Systema Naturae (10th edition) in 1758, initially encompassing all known cone snails within a single genus, with approximately 30 species described based on shell characteristics from global collections.^[70] This Linnaean framework treated the diverse morphologies of cone snails as variations within one taxon, reflecting the limited understanding of their biology at the time. Throughout the 19th and early 20th centuries, taxonomists expanded the classification by introducing subgenera primarily based on shell shape, sculpture, and coloration, as anatomical details like the venom apparatus were not yet central to systematics. A key contribution came from William J. Clench in 1942, who proposed subgenera such as Dauciconus and Jaspidiconus for western Atlantic species, emphasizing regional shell variations to organize the growing number of described taxa. By the 1990s, around 500 species were recognized within Conus, highlighting the genus's remarkable diversity but also the challenges in delineating boundaries solely on morphological grounds. In 1993, John D. Taylor and colleagues provided the first detailed anatomical classification of the superfamily Conoidea, analyzing foregut structures and feeding mechanisms across families, which suggested the polyphyly of Conus by revealing deep divergences unsupported by traditional shell-based groupings.^[71] This work marked a shift toward integrating internal anatomy, laying groundwork for questioning the monophyly of the genus. Building on emerging molecular data, John K. Tucker and Manuel J. Tenorio proposed a major revision in 2009, elevating many subgenera to full genera and recognizing 82 genera within three families for over 600 living cone snail species, based on combined morphological and preliminary genetic evidence.^[72] In 2011, Philippe Bouchet and coauthors refined this framework in a new operational classification of the Conoidea, incorporating molecular phylogenies to validate 82 taxa and underscore the need for further splits in Conus sensu lato, paving the way for contemporary taxonomy.

Diversity and genera

Cone snails, belonging to the family Conidae, exhibit remarkable diversity, with over 1,000 valid species worldwide. This family is classified into 8 principal genera—Californiconus, Conasprella, Conus, Kenyonia, Lilliconus, Profundiconus, Pseudolilliconus, and Pygmaeconus—encompassing numerous subgenera, based on molecular phylogenetic analyses and updates to the 2015 framework.^[68]^[69] The genus Conus dominates with over 700 species, primarily inhabiting shallow tropical waters, while Conasprella includes around 160 species specialized as worm-hunters. Deep-sea adapted groups, such as Profundiconus with approximately 30 species, occupy colder, abyssal environments.^[73]^[74] Diversity is highest in the Indo-West Pacific region, which hosts over 60% of all known species, exceeding 600 taxa.^[24] Regional hotspots include the Philippines, with more than 150 species recorded, and Australia, supporting around 150 species, reflecting the family's concentration in coral reef and subtropical habitats.^[27]^[75] Species delineation in cone snails faces significant challenges due to cryptic species—morphologically similar but genetically distinct forms—and evidence of hybridization, complicating traditional taxonomy. Molecular studies suggest that up to 20% of the actual diversity remains undescribed, particularly in understudied deep-water and remote reef populations.^[57] Recent assessments confirm one extinction (Conus lugubris, 2025 IUCN update).^[29] Conservation assessments by the IUCN indicate that approximately 10-15% of evaluated cone snail species are threatened or near-threatened, primarily due to their rarity, limited distributions, and pressures from habitat loss and collection.^[27]

Human relevance

Risks to humans

Cone snails pose risks to humans primarily through accidental envenomation via their harpoon-like radular tooth, which can penetrate skin during handling of live specimens, often by shell collectors or divers.^[3] The venom, composed of conotoxins, includes peptides such as δ-conotoxins that block or modulate voltage-gated sodium channels, leading to intense localized pain by disrupting nerve signaling.^[3] Envenomations are rare globally, with fewer than 200 documented cases historically, most occurring among individuals handling the snails in tropical marine environments.^[76] Symptoms of a cone snail sting typically begin with sharp, burning pain at the site, followed by swelling, numbness, and tingling that may radiate proximally.^[3] In severe cases, particularly from piscivorous species like Conus geographus (known as the "cigarette snail" due to the time victims have to smoke one last cigarette before death), systemic effects can include muscle paralysis, respiratory failure, and coma, progressing within hours if untreated.^[38] Approximately 30 to 36 fatalities have been recorded worldwide, predominantly before 2000 and attributed to C. geographus, with no confirmed deaths reported in recent years owing to increased awareness and prompt medical intervention.^[76] There is no specific antivenom available for cone snail envenomations, so first aid focuses on symptom management and rapid transport to a medical facility.^[3] Immediate measures include immobilizing the affected limb to slow venom spread, immersing the sting site in hot water (as tolerable, up to 45–50°C) for 30–90 minutes to denature heat-labile toxins and alleviate pain, and monitoring for respiratory distress.^[3] Supportive care in a hospital setting, such as mechanical ventilation if needed, is critical for severe cases.^[3]

Biomedical applications

Cone snail venoms contain conotoxins, a diverse array of disulfide-rich peptides with high specificity for ion channels and receptors, making them valuable for biomedical research and drug development. The most prominent example is ziconotide (Prialt), an ω-conotoxin MVIIA derived from Conus magus, approved by the FDA in 2004 for intrathecal treatment of severe chronic pain in patients unresponsive to other therapies. By selectively antagonizing N-type voltage-gated calcium channels (Ca_v2.2), ziconotide inhibits glutamate and substance P release in the spinal cord, providing non-opioid analgesia without respiratory depression or addiction risk.^[77]^[78]^[79] Ongoing research explores conotoxins for additional therapeutic applications, particularly in neurology. Mu-conotoxins, such as μ-conotoxin CnIIIC, block skeletal muscle voltage-gated sodium channels (Na_v1.4), offering potential for treating muscle disorders like myotonia congenita by reducing hyperexcitability without affecting cardiac or neuronal channels. Alpha-conotoxins, including α-conotoxin Vc1.1, target nicotinic acetylcholine receptors (nAChRs) and are under investigation for epilepsy, where nAChR dysregulation contributes to seizures, as well as neuropathic pain and inflammatory conditions. Several conotoxin analogs, such as contulakin-G and χ-conotoxin MrIA, have advanced to phase I/II clinical trials for pain and hypertension, though challenges like delivery and immunogenicity persist; as of 2024, at least five compounds remain in early-stage development.^[80]^[81]^[82] Drug development from conotoxins involves solid-phase peptide synthesis to produce these complex, 10-40 amino acid sequences with multiple disulfide bonds, followed by oxidative folding to achieve native structure. A key hurdle is their poor pharmacokinetic profile, including rapid enzymatic degradation and limited oral bioavailability; this is addressed through backbone cyclization, which links the N- and C-termini via amide bonds, enhancing serum stability by up to 100-fold while preserving activity, as demonstrated in cyclic analogs of α-conotoxin RgIA and Vc1.1.^[83]^[84] Beyond neurology, conotoxins show promise in other areas. Chi-conotoxins, like χ-conotoxin MrIA, inhibit norepinephrine transporters and have insecticidal potential by disrupting insect neurotransmitter systems, with recombinant forms exhibiting lethality against agricultural pests in preclinical assays. Certain conotoxins, such as those targeting voltage-gated potassium channels, display anti-cancer effects by inducing apoptosis in tumor cells, with studies on Conus textile venom showing cytotoxicity against ovarian and leukemia cell lines via ion channel modulation. Biotech firms have driven this field, with historical examples like Cognetix patenting over 100 conotoxins.^[85]^[86]^[87]^[88]

Collecting and trade

Cone snails have long been prized by collectors for their ornate shells, with interest dating back to the 17th and 18th centuries when they featured prominently in European cabinets of curiosities due to their aesthetic appeal and exotic origins.^[8] During this period, a frenzy of shell collecting swept through Europe, fueled by trade routes such as those of the Dutch East India Company, which supplied rare specimens from tropical waters.^[89] Collecting peaked in the 1970s and 1980s, particularly in the Philippines, where the shell industry became a major export earner, with cone shells among the highly sought-after items traded internationally.^[90] Today, the trade in cone snail shells persists primarily for ornamental purposes, with specimens sold to collectors and jewelers; rare species can fetch prices ranging from $10 to over $500 per shell, depending on size, condition, and scarcity.^[91] While exact global volumes are difficult to quantify, the ornamental shell trade, including cones, involves tens of thousands of specimens annually, sourced mainly from Indo-Pacific regions.^[92] Collection methods remain labor-intensive, typically involving hand-gathering by free-diving or snorkeling in shallow tropical waters, often using tongs or nets to safely extract live snails without direct contact, as their venomous harpoon can pose risks to handlers.^[93]^[94] Efforts to establish aquaculture for cone snails have been limited and largely unsuccessful outside research settings, due to challenges in replicating their complex dietary and environmental needs, with most attempts focused on venom extraction rather than commercial shell production.^[95] Overharvesting has significantly impacted endemic species, such as Conus gloriamaris (the glory-of-the-sea cone), once among the rarest shells known, with only a few specimens documented until the 1960s; intensified collecting in the Solomon Islands subsequently flooded the market but depleted local populations.^[96]^[97] Habitat loss from coastal development, pollution, and destructive fishing exacerbates these pressures, particularly in biodiversity hotspots like the Indo-Pacific. In October 2025, the IUCN Red List confirmed the extinction of Conus lugubris, an endemic species from Cape Verde, underscoring the severity of these threats. According to the IUCN Red List, as of 2013 approximately 6.5% of assessed cone snail species (out of 632) are threatened with extinction globally, with higher rates—up to 45% as of 2016—in isolated regions like Cape Verde, where endemism amplifies vulnerability.^[27]^[64]^[29] Regulatory measures aim to curb these threats, though cone snails are not currently listed under CITES appendices.^[20] In Australia, collection of marine snails, including cones, is strictly regulated under state fisheries laws, with bans on taking live specimens in many areas to protect native biodiversity and prevent biosecurity risks.^[98] The Philippines, a major sourcing hub, has implemented fishing quotas and marine protected areas to limit cone snail harvesting, with ongoing enforcement as of 2025 to sustain populations amid trade demands.^[8]

References

[1]
Cone Snails: A Big Store of Conotoxins for Novel Drug Discovery - NIH
Dec 7, 2017 · Cone snails, a group of more than 700 species, have always been one of the focuses for new drug discovery. These venomous snails capture prey ...
[2]
Cone Snail Toxicity - StatPearls - NCBI Bookshelf - NIH
Cone snail envenomation is a rare but potentially lethal condition caused by venomous marine snails from the Conus genus, commonly found in tropical seas.Missing: characteristics | Show results with:characteristics
[3]
Research: Paleobiology of the Killer Cone Snails
Jun 1, 2015 · These animals are highly specialized predators and usually focus on one type of prey. Most cone snails eat worms, members of one subgroup eat ...
[4]
Cone Snails - Central and South Florida Gastropod Seashell ...
Jan 3, 2025 · Habitat: These snails prefer to live on sandy bottoms in shallow water. They are often found around shallow reefs. Diet: The cones are active ...
[5]
[PDF] Conus: First Comprehensive Conservation Red List Assessment of a ...
Dec 23, 2013 · All cone snails use venom to immobilize their prey. The diversity of venoms employed by a particular species in the capture of prey is a.
[6]
Different Cone Shells From Sanibel Florida | I Love Shelling
Sep 11, 2015 · Dusky cones have spiral ribs, while Alphabet and Florida cones are mostly smooth. Jaspers and Stearns are not found in the area.<|control11|><|separator|>
[7]
Cone Shells (Conidae) - Masters of Camouflage and Poison
Their name is because of their characteristic cone-shaped shells, some of which have smooth, others slightly ribbed surfaces and are often vividly coloured ...
[8]
Crystallographic relationships in the crossed lamellar microstructure ...
The crossed lamellar microstructure of mollusk shells shows a very complex hierarchical architecture constituted of long rod-shaped aragonite crystals.Missing: composition | Show results with:composition
[9]
Cone Shells, Family Conidae
Oct 16, 2025 · Each species' soft-parts has a distinct color pattern allowing experienced divers to identify it even if the shell is totally encrusted with ...
[10]
How Do 'Killer Snails' Kill Their Victims? - Science Friday
Jul 31, 2018 · Like a nose, the siphon sniffs out prey. Like protective armor, its tough calcium carbonate shell safeguards it from larger, hungry predators.
[11]
Predatory and Defensive Strategies in Cone Snails - ResearchGate
Feb 3, 2024 · actually have a stronger evolutionary role than anticipated, possibly more than predation. in some cases [30]. Toxins 2024, 16, x FOR PEER REVI ...<|control11|><|separator|>
[12]
Cone shells - The Australian Museum
Cone shells have a cone or cylindrical-shaped shell with a muscular foot and come in a wide range of colours and patterns.
[13]
Integrative taxonomy with shell, DNA and venomic data reveals ...
An integrative approach reveals a new species of cone snail. Shell morphology, DNA sequences, mRNA and amino acid sequences of toxins are analyzed.<|control11|><|separator|>
[14]
Prey-capture Strategies of Fish-hunting Cone Snails - PubMed Central
Sep 24, 2015 · Typically the gastropod radula is a flexible membrane with multiple chitinous plates (or teeth), arranged in transverse rows. However, in cone ...
[15]
(PDF) CONE SNAIL RADULA: A REVIEW OF THE MORPHOLOGY ...
Jun 13, 2023 · Cone snails utilize a hollow radular tooth to inject their target prey. The modification of this apparatus allows the predatory and venomous ...Missing: zones | Show results with:zones
[16]
Cone Snail Ballistics - Bailey-Matthews National Shell Museum
Sep 6, 2019 · Radular teeth of cone snails resemble harpoons, with the hollow shaft acting as a conduit to deliver venom to the prey (see enclosed scanning ...
[17]
The high speed radular prey strike of a fish-hunting cone snail
Aug 19, 2019 · During this priming step, the base of the radular harpoon engages a latch mechanism. Cone snails utilize a unique cellular latch composed of ...
[18]
First ultrastructural study of the formation of the hypodermic radula ...
Mar 29, 2019 · The teeth are formed by odontoblasts in the terminal part of the radular sac, appearing first as thin undifferentiated semi-enrolled plates, ...<|separator|>
[19]
[PDF] CONE SNAIL BIOLOGY, BIOPROSPECTING AND CONSERVATION
The venom apparatus of cone snails. This panel illustrates the dissected ... Mass spectrometry has become the method of choice to study the complexity of venoms.Missing: review | Show results with:review
[20]
Curses or Cures: A Review of the Numerous Benefits Versus the ...
Conotoxins form a diverse group of peptide toxins found in the venom of predatory marine cone snails. Decades of conotoxin research have provided numerous ...<|separator|>
[21]
Conotoxin Gene Superfamilies - PMC - PubMed Central - NIH
Currently, these peptides are classified in one of three ways: gene superfamily, cysteine framework or pharmacological family. Historically, conotoxins were ...
[22]
CONUS VENOM PEPTIDES: Reflections from the Biology of Clades ...
The fact that the life history of cone snails involves an enormous number of offspring means that mechanisms for the hypermutation of venom peptides could ...<|separator|>
[23]
[PDF] Molecular phylogeny and evolution of the cone snails ... - Archimer
Based on the tree, most species occur in the Indo-Pacific (IP), which may be the ancestral source of the Conidae (frequency of occurrence of Indo-Pacific region ...
[24]
[PDF] CONE SNAILS A SIGNIFICANT BIOMEDICAL RESOURCE AT RISK
Hotspots of endemism, particularly along the Eastern Atlantic found 42.9% of 98 species there at risk. This includes Cape Verde where 53 of 56 species are ...
[25]
Conus: First Comprehensive Conservation Red List Assessment of a ...
Dec 23, 2013 · We assessed the status of all 632 valid species of the tropical marine gastropod mollusc, Conus (cone snails), using Red List standards and procedures.
[26]
Revision of the deep-water cone snail fauna from New Caledonia ...
Oct 3, 2023 · A total of 76 different species of cone snails were identified among the collected material. ... (range: 1 April – 30 June 2025). Average ...
[27]
The role of the Sunda shelf biogeographic barrier in the cryptic ...
Jul 14, 2023 · The type of larval development has a significant impact on the dispersal abilities of these venomous marine snails (Cunha et al., 2005).
[28]
Conus | INFORMATION - Animal Diversity Web
Conidae. Genus, Conus. By Triston Childs. Diversity. Conus is one of the most diverse and species rich genera of marine animals (with over 500 extant species) ...
[29]
Cone snail species off the Brazilian coast and their venoms
The so-called cone snails are distributed throughout the globe, predominantly in tropical waters. These animals usually dwell near reefs, burying in the sand ...
[30]
Conus geographus (geography cone snail) - Animal Diversity Web
Their surrounding habitat includes living or fragmented coral reefs, and sandy regions within tidal zones. They are less commonly found in deeper waters.
[31]
Microhabitats within Venomous Cone Snails Contain Diverse ... - NIH
Typically, the water temperature in Cebu ranges between 26°C and 29°C. The three different snails, C. pulicarius, C. tribblei, and C. rolani, were ...
[32]
(PDF) Investigating the Future: Simulating Cone Snail's Response to ...
Mar 10, 2024 · ... range of salinities (5–40 ppt) at 20°C, but the salinity tolerance range narrowed as the temperature decreased or increased. Additionally ...
[33]
(PDF) The Ecology of Conus in Hawaii - ResearchGate
Aug 5, 2025 · The Ecology of Conus in Hawaii. Wiley. Ecological Monographs ... The genus Conus contains about 700 species of marine snails that are ...
[34]
Dietary breadth is positively correlated with venom complexity in ...
May 26, 2016 · Our results corroborate the key role of diet in influencing patterns of venom evolution in cone snails and other venomous radiations.Missing: review | Show results with:review<|control11|><|separator|>
[35]
to fish-hunting in a venomous cone snail | Nature Communications
Jun 13, 2023 · The venom apparatus of marine cone snails (Gastropoda: Conidae) is an example of evolutionary innovation that evolved through morphological ...
[36]
Predatory and Defensive Strategies in Cone Snails - PMC
... role than anticipated, possibly more than predation in some cases [30]. Figure 5. Figure 5 · Open in a new tab. Natural predators of cone snails. ... structure ...
[37]
The strategy used by some piscivorous cone snails to capture their ...
All of them used a `hook and line' strategy which consists of immobilizing the prey rapidly before engulfing it.Missing: review | Show results with:review
[38]
Strategy for rapid immobilization of prey by a fish-hunting marine snail
The purple cone, Conus purpurascens, uses two parallel physiological mechanisms requiring multiple neurotoxins to immobilize fish rapidly: neuromuscular ...
[39]
Cone Snails Use Sexual Enticements to Lure Prey Out of Hiding
Mar 30, 2021 · Cone snails use a harpoon-like tooth at the end of their proboscis to inject venom into prey, instantly paralyzing them. Then, they slowly reel ...
[40]
Somatostatin venom analogs evolved by fish-hunting cone snails
Mar 23, 2022 · We show that predator-prey evolution has generated a diverse set of SS analogs, each optimized to elicit specific systemic physiological effects in prey.
[41]
Piscivorous Behavior of a Temperate Cone Snail, Conus californicus
Conus californicus Hinds, 1844, is unusual in that it is endemic to the North American Pacific coast and preys on a large variety of benthic organisms, ...
[42]
Piscivorous behavior of a temperate cone snail, Conus californicus
During the course of the study, snails became aroused by the presence of live fish more quickly, as evidenced by more rapid initiation of hunting behavior.Missing: scientific | Show results with:scientific
[43]
[PDF] Description of the feeding rhythm of cone snails in French Polynesia
May 20, 2024 · In this study, we investigated diet through hunger and satiety experiments of eight species of cones that occur in French Polynesia and that ...
[44]
Eocene gastropods of the New Forest, UK - Wiley Online Library
Jan 24, 2025 · The marine Eocene sediments of the Hampshire Basin in southern England are particularly well-known for their abundant fossils, especially ...
[45]
[PDF] Species-level phylogeography and evolutionary history of the ...
Nov 19, 2004 · The fossil record also demonstrates that Conus radi- ated rapidly throughout its distribution during the Mio- cene (Table 1; Kohn, 1990).
[46]
Diversity and preserved shell coloration patterns of Miocene ...
May 24, 2018 · Cone snails have a fossil record that extends back to the early Eocene (Kohn, 1990; Röckel et al., Reference Röckel, Korn and Kohn1995; ...
[47]
(PDF) Evolution of the Radular Apparatus in Conoidea (Gastropoda
Aug 7, 2025 · The anatomy and evolution of the radular apparatus in predatory marine gastropods of the superfamily Conoidea is reconstructed on the basis of a ...
[48]
Body-size evolution in gastropods across the Plio-Pleistocene ...
Dec 13, 2024 · This extinction was associated with declining nutrient conditions and has been presumed to be associated with a decrease in molluscan body size.
[49]
The Terebridae and teretoxins: Combining phylogeny and anatomy ...
Sep 17, 2010 · The Conoidea superfamily, comprised of cone snails, terebrids, and turrids, is an exceptionally promising group for the discovery of natural peptide toxins.
[50]
A short sequence with high signal elucidates cone snail phylogeny
The present framework for understanding Conus evolution is based on both the fossil record and molecular phylogenetics. The fossil record suggests two major ...Missing: challenged | Show results with:challenged
[51]
[PDF] Molecular phylogeny and evolution of the cone snails (Gastropoda ...
Jun 2, 2014 · tive of the diversity of the group, or largely unresolved. 70. The gastropod family Conidae, commonly known as cone snails,. 71 includes the ...<|control11|><|separator|>
[52]
Biomedical Potential of the Neglected Molluscivorous and ...
Jan 27, 2022 · It is generally believed that more than 700 Conus species have evolved during the last 50 million years [1,2]. With the highest species ...
[53]
Molecular phylogeny and evolution of the cone snails (Gastropoda ...
We present a large-scale molecular phylogeny that includes 320 of the 761 recognized valid species of the cone snails (Conus), one of the most diverse groups ...
[54]
Molecular phylogeny and evolution of the cone snails (Gastropoda ...
The gastropod family Conidae, commonly known as cone snails, includes the widely distributed, mainly tropical genus Conus, a relatively young genus (appearance ...
[55]
Prey Shifts Drive Venom Evolution in Cone Snails - Oxford Academic
Venoms are mixtures of bioactive compounds that are used by many organisms to incapacitate prey or defend against predators. Venom systems have independently ...
[56]
Insights into the origins of fish hunting in venomous cone snails from ...
Apr 6, 2015 · The combination of results from molecular neuroscience, phylogenetic analysis, and chemical biology demonstrates that an ancestral cone snail ...
[57]
(PDF) One, four or 100 genera? A new classification of the cone snails
We present a new classification for the genus Conus sensu lato (family Conidae), based on molecular phylogenetic analyses of 329 species.
[58]
https://pmc.ncbi.nlm.nih.gov/articles/PMC5556946/
[59]
[PDF] Larval Growth and Metamorphosis of Conus (Castropoda: Toxoglossa)
Dec 22, 1980 · Larval shell growth and dry weight increase was monitored by ... veliger larva ready for metamorphosis. Size and developmental state of the velum.Missing: cone snail
[60]
The cone snails of Cape Verde: Marine endemism at a terrestrial scale
Number of Conus species occurring on each Cape Verde island by category of threat. ... Larval growth and metamorphosis of Conus (Castropoda: Toxoglossa) in Hawaii.<|control11|><|separator|>
[61]
Effects of microalgal prey, biofilm, and reduced salinity - J-Stage
Sep 5, 2025 · In the starved group, larval survival declined steadily from three days after hatching, and all larvae had died by day 12 (Fig. 2A). In the ...
[62]
Metamorphic Remodeling of a Planktotrophic Larva to Produce the ...
I used histological sections and 3D reconstruc- tions to document development through metamorphosis of the foregut and proboscis in the conoidean neogastropod.<|control11|><|separator|>
[63]
Growth, Fecundity, and Mortality of Conus Pennaceus in Hawaii
Although growth rates of Conus pennaceus show considerable variability, a highly significant size-spe- cific component of growth is observed when growth rate is ...Missing: maturity | Show results with:maturity
[64]
One, four or 100 genera? A new classification of the cone snails
Sep 5, 2014 · We present a new classification for the genus Conus sensu lato (family Conidae), based on molecular phylogenetic analyses of 329 species. This ...
[65]
World Register of Marine Species - Conidae J. Fleming, 1822
Pictoconus, new genus from South Africa and Profundiconinae, new subfamily (Gastropoda: Conidae). ... A new classification of the cone snails. Journal of ...
[66]
World Register of Marine Species - Conus Linnaeus, 1758 - WoRMS
Species Conus aliceae (Petuch & Berschauer, 2025); Species Conus ... Alphabetical revision of the (sub)species in recent Conidae. Basteria. 1 ...
[67]
Foregut anatomy, feeding mechanisms, relationships and ...
Feb 14, 2020 · The Conoidea are considered to be monophyletic, because the families share the common apomorphy of a venom apparatus con-sisting of the venom ...
[68]
https://www.marinespecies.org/aphia.php?p=taxdetails&id=14107
[69]
Recognition of Conus species using a combined approach of ...
Dec 9, 2024 · Cone snails are venomous marine gastropods comprising more than 950 species widely distributed across different habitats.
[70]
Unveiling the enigmatic cone snails along the coastal environments ...
Oct 2, 2024 · To understand the vertical distribution of Conids, the intertidal area was divided into three zones, high-, mid- and low- waterline zones.
[71]
The deadly, life-saving cone shells - Taxonomy Australia
Mar 26, 2019 · Around 150 species are known from Australia. Shallow-water species are relatively well-known, but many new species are still being discovered ...
[72]
Human injuries and fatalities due to venomous marine snails of the ...
Death occurred in 36 cases, 57 cases presented with serious symptoms but recovered completely, and in 44 cases victims were only minimally affected. A few cases ...
[73]
Conus Envenomation of Humans: In Fact and Fiction - MDPI
Dec 27, 2018 · 2.7. While cone snails have killed more than 30 people and injured more than a hundred others, many conotoxins are under intensive study for ...
[74]
Drug Approval Package: Prialt (Ziconotide Intrathecal Infusion) NDA ...
Prialt (Ziconotide Intrathecal Infusion) Company: Elan Pharmaceuticals Application No.: 021060 Approval Date: 12/28/2004 Date created: April 222005Missing: cone snail
[75]
Ziconotide: Uses, Interactions, Mechanism of Action | DrugBank Online
Ziconotide belongs to the ω-conotoxin class of neurotoxic peptides derived from the cone snail Conus magus which are capable of inhibiting N-type VGCCs.
[76]
Pain Therapeutics from Cone Snail Venoms: From Ziconotide to ...
May 16, 2018 · Ziconotide, Contulakin-G, Vc1.1 and MrIA were novel drug leads for pain and simultaneously revealed new pathways of pain signaling. These ...
[77]
Voltage-Gated Sodium Channel Inhibition by µ-Conotoxins - MDPI
µ-Conotoxins are small, potent pore-blocker inhibitors of voltage-gated sodium (NaV) channels, which have been identified as pharmacological probes and ...Missing: trials | Show results with:trials
[78]
Conotoxins Targeting Nicotinic Acetylcholine Receptors: An Overview
This review aims to give an overview of the knowledge we have today on the molecular pharmacology of conotoxins specifically interacting with nAChRs.
[79]
[PDF] Characterizing new conotoxin interactions with G protein-coupled ...
Aug 21, 2025 · Some conotoxins have reached phase I or II of clinical trials, such as ACV1 for neuropathic pain or ω-CVID for chronic pain, but have been ...
[80]
Backbone cyclization of analgesic conotoxin GeXIVA facilitates ...
Overall, this study highlights the value of backbone cyclization in directing folding, improving yields, and stabilizing conotoxins with therapeutic potential.
[81]
Cyclization of conotoxins to improve their biopharmaceutical ...
One strategy for improving the stability of conotoxins, which we have adopted, is backbone cyclization (Armishaw et al., 2010, Clark et al., 2005, Clark et al., ...
[82]
Recombinant conotoxin, TxVIA, produced in yeast has insecticidal ...
This paper reports the production of a conotoxin, TxVIA from Conus textile, as a biologically active recombinant protein, using the yeast Pichia pastoris as ...
[83]
Screening and Validation of Highly-Efficient Insecticidal Conotoxins ...
In our current study, six conotoxins with potential insecticidal activity were screened out from our conotoxin library by homologous search with a reported ...
[84]
Anti-Ovarian Cancer Conotoxins Identified from Conus Venom - PMC
Oct 5, 2022 · This work highlights the role of conotoxin libraries in subsequent drug discovery for ovarian cancer treatment.
[85]
The snail companies. Neurex Corporation & Cognetix Inc - PubMed
Technology, Pharmaceutical*; omega-Conotoxins*. Substances. Calcium Channel Blockers; Mollusk Venoms; Neuroprotective Agents; Peptides; omega-Conotoxins ...
[86]
8 things we've discovered about the story of shells, artists and ...
Sep 7, 2022 · The 18th century was to see a shell-collecting frenzy take hold of European collectors. The Dutch East India Company played a major role in this ...
[87]
[PDF] The Philippine Shell Industry with Special Focus on Mactan, Cebu
The shell industry became a significant dollar earner for the country for several decades during the. 1970's and 1980's. In 1988, export of shells and ...<|separator|>
[88]
Conus shells for collectors | Conidae
SEASHELL Conus Milneedwardsi clytospira Excellent HUGE 162mm !!! Rare size !!! Current Price: $350. Buy it Now.Missing: trade annual
[89]
[PDF] International Trade Ornamental Shells - IUCN Portal
100 tonnes of 'green snail shell' ( Turbo marmoratus) were exported annually to Japan, Singapore, South Korea, and other countries. Smaller quantities (an.
[90]
Collecting Cone Shells: Special Handling Required - The Right Blue
If you find shells -- including Cone Shells -- while diving, it's convenient to carry them in a small mesh bag that you can clip to a D-ring on the outside of ...Missing: methods aquaculture
[91]
Killer snails: Working with deadly sea creatures - JCU Australia
“We use tongs, so when we see them we snorkel down and we get our net and we get our tongs and we gently pick them up and pop them in a net. We also have ...Missing: methods | Show results with:methods
[92]
Farming killer cone snails for research is a risky affair
Nov 28, 2004 · Farming killer cone snails for research is a risky affair ... Out of four tries that day, only one milking was successful. Bingham ...Missing: aquaculture attempts
[93]
Glory of the Sea: C. gloriamaris
For two hundred years, Conus gloriamaris, the "Glory of the Sea," was the rarest shell in the world, with only a dozen or so examples known to exist.
[94]
https://www.jcu.edu.au/this-is-uni/natural-and-built-environments/articles/killer-snails-working-with-deadly-sea-creatures
[95]
Bringing or mailing goods to Australia - DAFF
Apr 9, 2025 · You must declare if you are carrying certain food, plant material or animal products. You can take these declared goods with you to the clearance point.Sending or ordering goods... · Khapra beetle urgent actions · Unique or exotic petsMissing: cone | Show results with:cone