Fact-checked by Grok 2 weeks ago

Haemaccel

Haemaccel is a synthetic colloid plasma volume substitute consisting of 3.5% polygeline (a modified gelatin derived from bovine collagen) dissolved in an electrolyte solution containing sodium chloride, potassium chloride, and calcium chloride, designed for intravenous infusion to restore and maintain blood volume in cases of acute hypovolaemia.^[1] Developed as an alternative to natural plasma or crystalloid solutions, Haemaccel has a mean molecular weight of approximately 30-35 kDa, providing oncotic pressure similar to human plasma albumin but with a shorter intravascular half-life of about 3-5 hours and no oxygen-carrying capacity.^[2]^[1] It is primarily indicated for the initial management of hypovolaemic shock due to haemorrhage (overt or concealed), burns, peritonitis, pancreatitis, or crush injuries, as well as for fluid replacement during plasma exchange procedures, extra-corporeal circulation in cardiac surgery, and isolated organ perfusion.^[1] In clinical use, Haemaccel is administered intravenously, with initial doses of 500-1,000 ml for adults in shock, potentially replacing up to 1,500 ml of blood loss entirely or combining with blood products for larger volumes (1,500-4,000 ml); for burns, the dosage is calculated as 1 ml per kg body weight per percentage of body surface area burned over 24 hours.^[1] The solution must be used cautiously in patients with heart failure, hypertension, or renal impairment due to risks of fluid overload and electrolyte imbalances, and it is contraindicated in those with hypersensitivity to its components or a history of severe anaphylactoid reactions to colloids.^[1] Common side effects include mild hypersensitivity reactions such as urticaria or hypotension, while rare but serious risks involve anaphylaxis or circulatory overload, necessitating immediate treatment with antihistamines, corticosteroids, or adrenaline.^[1] Originally authorised in the UK on 12 January 2005 and last revised in 2019, Haemaccel remains a key component in emergency and perioperative fluid therapy, though its use has evolved with ongoing debates about the comparative safety and efficacy of synthetic colloids versus crystalloids in resuscitation protocols.^[1]^[3]

Medical Uses

Hypovolemic Shock Treatment

Hypovolemic shock is a life-threatening condition characterized by a significant reduction in intravascular blood volume, leading to inadequate tissue perfusion and oxygenation despite compensatory mechanisms such as tachycardia and vasoconstriction.^[4] Common causes include acute hemorrhage from trauma or surgery, severe burns, peritonitis, pancreatitis, crush injuries, and substantial fluid losses from prolonged vomiting or diarrhea.^[4] In these scenarios, rapid restoration of circulating volume is essential to prevent organ failure and mortality. Haemaccel, a polygeline-based colloid solution, serves as an effective plasma volume expander in the initial management of hypovolemic shock by increasing oncotic pressure and maintaining intravascular volume.^[1] Clinical guidelines recommend infusing 500–1,000 ml intravenously as an initial bolus to stabilize hemodynamics.^[5] For blood losses up to 1,500 ml, Haemaccel can replace the entire volume without immediate need for blood products; for losses between 1,500 ml and 4,000 ml, replacement should use equal volumes of Haemaccel and whole blood to optimize volume expansion while addressing oxygen-carrying capacity.^[5] Evidence from clinical studies supports Haemaccel's efficacy in hypovolemic shock, particularly in trauma settings. A prospective observational study of 60 adult patients with trauma-induced hypovolemia demonstrated that Haemaccel infusion significantly improved hemodynamic parameters, including mean arterial pressure and heart rate, achieving stability without major adverse events.^[6] Prospective studies in accidental trauma cases further confirmed its safety and effectiveness in restoring circulatory volume post-injury.^[7] Compared to crystalloids like Ringer's solution, Haemaccel requires less volume for equivalent resuscitation while providing superior circulatory filling and longer duration of action due to its colloidal properties, as shown in postoperative fluid therapy trials.^[3]^[8] In emergency settings, such as postoperative care or acute fluid resuscitation during trauma, Haemaccel plays a critical role in bridging the gap until blood products are available, with its mean half-life of about 5 hours allowing sustained volume support.^[1] This makes it particularly valuable in resource-limited environments where rapid infusion is needed to mitigate shock progression.^[8]

Supportive Therapy in Ascites

Ascites refers to the pathological accumulation of fluid in the peritoneal cavity, most commonly associated with advanced liver cirrhosis due to portal hypertension and hypoalbuminemia.^[9] Large-volume paracentesis, the therapeutic removal of more than 5 liters of ascitic fluid, is a standard procedure to alleviate symptoms such as abdominal distension and discomfort in patients with tense or refractory ascites.^[9] However, this intervention carries a risk of post-paracentesis circulatory dysfunction (PPCD), characterized by a rapid decrease in systemic vascular resistance, leading to hypotension, accelerated ascites reaccumulation, dilutional hyponatremia, and potential renal impairment if not prophylactically managed.^[9] Although not a licensed indication, Haemaccel has been used off-label as a cost-effective alternative to human albumin solution (HAS) for plasma volume expansion following large-volume paracentesis in cirrhotic patients with ascites. Clinical guidelines recommend human albumin (8 g per liter of ascites removed) as the preferred expander to prevent PPCD; Haemaccel serves as a lower-cost alternative in settings where albumin is unavailable.^[10] It helps maintain effective circulating volume and prevent PPCD by providing oncotic pressure similar to albumin, with typical protocols recommending approximately 4-8 g of polygeline per liter of ascitic fluid removed (e.g., 125-150 mL of 3.5% Haemaccel solution per liter, equivalent to 4.4-5.3 g).^[11]^[12] Its electrolyte composition, including sodium and chloride, also supports salt replacement during fluid shifts.^[13] Clinical studies demonstrate that Haemaccel reduces the incidence of hyponatremia and renal impairment compared to no colloid infusion after paracentesis. A randomized trial comparing Haemaccel to albumin in 54 cirrhotic patients with refractory ascites found no significant differences in complications, including renal function markers, indicating Haemaccel's efficacy in preventing PPCD-equivalent outcomes.^[13] Another study in patients with tense ascites showed that 125 mL/L Haemaccel infusion resulted in only minor, insignificant declines in serum sodium (from 134.9 ± 6.5 to 134.2 ± 4.3 mmol/L) and stable or slightly improved glomerular filtration rates (from 75.5 ± 15.8 to 77.9 ± 2.4 mL/min), comparable to albumin and superior to scenarios without volume expansion.^[11] Broader evidence from a Cochrane review of plasma expanders, including polygeline, confirms that colloids lower PPCD risk (RR 0.32, 95% CI 0.12-0.84) and associated hyponatremia and renal issues relative to no expander, though certainty is low due to study limitations.^[12] In resource-limited settings, Haemaccel offers advantages over synthetic starch solutions like hydroxyethyl starch due to its greater availability, lower cost (approximately one-tenth that of albumin), and established safety profile without increased risks of renal impairment or hyponatremia in short-term use.^[11]^[12]

Composition and Pharmacology

Chemical Composition

Haemaccel is formulated as a 3.5% w/v solution of polygeline, the active ingredient, which is a succinylated gelatin derived from bovine collagen with a mean molecular weight of 30–35 kDa. This colloid provides oncotic pressure similar to plasma without contributing to oxygen transport, as it lacks hemoglobin or other oxygen-carrying components.^[1]^[14] The electrolyte profile per liter consists of sodium chloride supplying 145 mmol/L of Na⁺, potassium chloride providing 5.1 mmol/L of K⁺, and calcium chloride contributing 6.25 mmol/L of Ca²⁺, for a total chloride content of 145 mmol/L to maintain ionic balance compatible with plasma.^[15]^[16] With an osmolality of approximately 300 mOsm/L, the solution is iso-osmotic to human plasma, and its pH is maintained at 7.3 ± 0.3 to ensure stability and physiological tolerability.^[16] Haemaccel is supplied as a sterile, pyrogen-free solution in 500 ml plastic bottles designed for intravenous infusion.^[1]

Pharmacokinetics and Mechanism

Haemaccel, a polygeline-based colloid solution, functions primarily as a plasma volume expander by exerting oncotic pressure comparable to that of plasma, which draws fluid from the extravascular space into the intravascular compartment to restore circulating volume in hypovolemia.^[1] This iso-oncotic property, derived from its mean molecular weight of 30,000 Daltons, enables it to remain predominantly within the vascular space without contributing to oxygen transport, distinguishing it from oxygen-carrying blood products.^[1] Unlike crystalloid solutions, which achieve only about 25% of the infused volume as effective plasma expansion due to rapid distribution into interstitial spaces, Haemaccel provides approximately 80% initial intravascular volume expansion relative to the infused amount, owing to its larger molecular size that limits leakage across capillary walls.^[17] Upon intravenous administration, Haemaccel is rapidly distributed within the plasma compartment, achieving immediate volume expansion effects that peak shortly after infusion.^[1] Its pharmacokinetic profile includes a mean half-life of about 5 hours in individuals with normal renal function, during which it maintains hemodynamic stability for 4-6 hours, necessitating clinical monitoring for potential re-dosing to sustain volume support.^[1] In patients with renal impairment, this half-life can extend up to 16 hours due to reduced excretion capacity.^[18] The solution undergoes metabolism via proteolysis by endogenous enzymes, breaking down into smaller peptides and amino acids, while a significant portion is excreted unchanged through the kidneys, with approximately 74% eliminated within four days post-administration.^[1] This dual pathway of elimination—metabolic degradation and renal clearance—contributes to its relatively short duration of action compared to other colloids, reducing the overall fluid volume required for resuscitation while minimizing prolonged accumulation in the body.^[1]

Administration and Dosage

Dosage Recommendations

Haemaccel is typically administered intravenously to adults in hypovolemic shock at an initial dose of 500-1,000 ml, infused rapidly and titrated based on clinical response, such as normalization of blood pressure and heart rate.^[1] For blood losses up to 1,500 ml, Haemaccel can replace the volume on a 1:1 basis; losses between 1,500 ml and 4,000 ml require equal volumes of Haemaccel and blood products, administered separately; for losses exceeding 4,000 ml, a 2:1 ratio of blood to Haemaccel is recommended, while maintaining hematocrit above 25%.^[1] Although the safety and efficacy in children has not been established per the UK SmPC, studies in pediatric septic shock suggest an initial bolus of 20 ml/kg, with further boluses as needed up to hemodynamic stability, and close monitoring.^[19] For plasma exchange procedures, up to 2 litres may be used alone or in combination with other fluids.^[1] Use in burns is addressed in the Medical Uses section. In patients with renal or hepatic impairment, use is restricted, particularly in renal and post-renal anuria, with special precautions required; no specific dose reductions are recommended.^[5]^[1] Dosing should be guided by monitoring parameters such as central venous pressure, urine output (target >0.5 ml/kg/hour), and overall clinical response to prevent over- or under-resuscitation.^[1] Re-dosing intervals may consider the solution's plasma half-life of approximately 5 hours in normal renal function.^[1]

Administration Procedures

Haemaccel is administered solely by intravenous infusion, utilizing either a peripheral or central venous access line to ensure proper delivery into the bloodstream. Administration via intramuscular or subcutaneous routes is contraindicated, as it may lead to local tissue irritation, necrosis, or ineffective plasma volume expansion.^[1] Before infusion, the solution must be visually inspected for particulate matter, discoloration, or cloudiness, and the integrity of the container seal should be confirmed; discard if any abnormalities are present or if the solution has gelled due to exposure to low temperatures. To prepare, disinfect the bottle's rubber stopper, remove the protective seal, and firmly insert the spike of a sterile infusion set; if necessary, warm the solution to body temperature (approximately 37°C) using a water bath or approved warmer to enhance patient comfort and reduce viscosity, though in urgent situations, room-temperature infusion is acceptable. Water-soluble medications compatible with Haemaccel, such as insulin, may be added directly to the bottle through a designated injection port while strictly adhering to aseptic techniques to prevent contamination. Haemaccel can be co-administered with whole blood or blood components using a Y-type infusion set, allowing separate lines to merge at the patient end, but direct mixing in the same container should be avoided to prevent potential interactions.^[1] Infusion rates are tailored to the patient's clinical status, with a standard rate of 500 ml over at least 60 minutes (approximately 8–10 ml/min) for most adults to minimize risks such as fluid overload. In cases of acute hypovolemia or shock requiring rapid volume expansion, faster rates are permissible, guided by hemodynamic monitoring to achieve prompt stabilization. For elderly patients or those with underlying cardiac conditions, a reduced rate of around 10 ml/min or slower is advised to mitigate the potential for pulmonary edema or exacerbated heart failure, with close observation of vital signs during administration.^[1] Haemaccel demonstrates good compatibility with common intravenous fluids including 0.9% sodium chloride, 5% dextrose, and Ringer's lactate, as well as heparinized blood, facilitating combined use in resuscitation protocols. It is incompatible with citrated blood products owing to the presence of calcium ions, which can induce clotting; in such scenarios, the infusion line must be flushed between administrations. While stable with many IV medications—such as penicillins, corticosteroids, and insulin—specific incompatibilities exist, including precipitation with vancomycin and heightened nephrotoxicity risk when combined with gentamicin; always consult compatibility data before co-infusion.^[1]^[20] Unopened containers of Haemaccel should be stored with no special precautions required. The shelf life is 2 years from the date of manufacture; once opened, the solution must be used immediately, and any remaining volume discarded to avoid bacterial contamination. Always verify the expiration date and discard if outdated or showing signs of compromise.^[1]

Adverse Effects and Safety

Common Reactions

Haemaccel, a polygeline-based colloid solution, is associated with an incidence of adverse reactions of 0.78% as reported in a 1983 multicentre prospective study, with the majority being mild and transient in nature.^[21] Severe hypersensitivity reactions are rare.^[1] These reactions are primarily histamine-mediated and include cutaneous manifestations such as urticaria (wheals), rash, and pruritus, as well as cardiovascular effects like hypotension, tachycardia, or bradycardia.^[1]^[5] Gastrointestinal symptoms, including nausea and vomiting, are also commonly reported.^[1] Other frequent effects encompass flushing, pyrexia, and chills, while bronchospasm and angioedema occur less commonly but remain notable among mild reactions.^[6]^[2] These anaphylactoid reactions stem from the gelatin component of polygeline, which can trigger histamine release.^[22] Patients with a history of atopy or prior exposure to gelatin products face an increased likelihood of experiencing these reactions.^[23] For management of mild cases, reducing the infusion rate or administering antihistamines, such as an H1 antagonist like chlorpheniramine (10-20 mg intravenously), is recommended to alleviate symptoms.^[1]^[16]

Contraindications and Precautions

Haemaccel is contraindicated in patients with known hypersensitivity to any of its constituents, including polygeline or the electrolytes sodium chloride, potassium chloride, and calcium chloride. It is also absolutely contraindicated in individuals with a history of severe anaphylactoid reactions to gelatin-based colloids, as these can recur upon re-exposure.^[1]^[5] Relative precautions are advised in several patient populations due to the risk of exacerbating underlying conditions. Use is restricted in cases of congestive heart failure, hypertension, oesophageal varices, pulmonary oedema, haemorrhagic diathesis, and renal or post-renal anuria, where volume expansion may lead to circulatory overload or impaired excretion. In patients with renal impairment, monitoring for polygeline accumulation is essential, as reduced clearance can prolong effects and heighten toxicity risks. Caution is recommended in hypercalcaemia or when administering cardiac glycosides, owing to Haemaccel's calcium content (approximately 0.102 g calcium chloride dihydrate per 500 ml), which may potentiate digitalis toxicity. Additionally, rapid infusion should be avoided to prevent the release of vasoactive substances and histamine, particularly in allergic individuals or those recently exposed to histamine-liberating drugs; prophylactic administration of H1 and H2 receptor antagonists may be considered in high-risk cases. The solution's electrolyte profile—containing 145 mmol/L sodium and 5 mmol/L potassium—necessitates monitoring in patients on sodium- or potassium-controlled diets to avoid imbalances.^[1]^[5]^[16] Drug interactions with Haemaccel primarily involve its electrolyte components and volume-expanding properties. Additive effects may occur when combined with other plasma volume expanders, increasing the risk of hypervolaemia. It should not be mixed directly with citrated blood products due to potential clotting from calcium ions neutralizing the citrate anticoagulant; if sequential administration is required, the infusion set must be flushed. Haemaccel is compatible with saline, dextrose solutions, Ringer's lactate, heparinized blood, and water-soluble drugs such as insulin or streptokinase. No specific interactions with ACE inhibitors have been documented for Haemaccel, though general caution with hypotensive agents applies in volume-depleted states.^[1]^[5] Regarding pregnancy and lactation, official product information states it may be used for plasma volume replacement during pregnancy or childbirth when blood is unavailable, with no apparent ill effects on mother or fetus reported in clinical use. Limited data are available for lactation, but excretion into breast milk is unlikely due to its large molecular size; use only if benefits outweigh risks.^[1]^[5]^[24] Overdosage with Haemaccel primarily manifests as fluid overload, potentially leading to pulmonary oedema, especially in patients with compromised cardiac or renal function. Symptoms include dyspnoea, elevated central venous pressure, and electrolyte disturbances; management involves discontinuing infusion, administering diuretics, and supportive care to restore fluid balance. No specific antidote exists.^[1]^[25]

History and Manufacturing

Development and Introduction

Haemaccel, a modified gelatin-based plasma substitute, was developed in the 1960s and 1970s by Hoechst AG in Germany to serve as an alternative to whole blood in situations of volume depletion, particularly to mitigate shortages of natural blood products during surgical and trauma care. The product was formulated as a urea-cross-linked polygeline solution to provide effective volume expansion with a favorable safety profile for emergency use. This development occurred amid growing demand for synthetic colloids following advancements in polymer chemistry and the need for stable, storable substitutes in medical settings.^[26] First marketed in Europe during the 1970s, Haemaccel was introduced primarily for volume replacement in hypovolemic states associated with surgery and trauma. Initial clinical trials emphasized its role in restoring circulatory volume rapidly without the risks of blood transfusions, such as incompatibility or transmission of infections. These early evaluations highlighted its utility in acute care environments, where it was administered intravenously to stabilize patients experiencing blood loss. By the mid-1970s, it had gained traction in European hospitals as a reliable option for perioperative fluid management. Haemaccel was withdrawn from the Australian market in 2004.^[27]^[28] Early studies in the 1970s and 1980s demonstrated Haemaccel's safety and efficacy in treating hypovolemia, with research focusing on its hemodynamic effects and duration of action. For instance, clinical investigations confirmed its ability to expand plasma volume effectively, with a reported half-life of approximately 4-5 hours, allowing for sustained support in critical conditions. Key publications from this period also examined potential adverse events, including anaphylactoid reactions, reporting an incidence of about 0.05% in large patient cohorts, which informed guidelines for monitoring during administration. These findings established Haemaccel as a viable colloid for short-term volume resuscitation.^[29]^[30] Regulatory approvals for Haemaccel as a medicinal product were obtained in the European Union during the 1970s, with approval in the United Kingdom granted on 12 January 2005. By the 1980s, it had achieved widespread global adoption, particularly in regions with limited access to blood banking infrastructure, solidifying its role in emergency medicine worldwide.^[23]^[1]

Ownership Changes

Haemaccel was originally produced by the German pharmaceutical company Hoechst AG, which developed and marketed the product following its introduction in the 1970s. Hoechst retained ownership until its merger with France's Rhône-Poulenc S.A. in 1999, forming Aventis, a global life sciences firm that continued production and distribution. In 2004, the subsequent entity Sanofi-Aventis—resulting from Aventis's merger with Sanofi-Synthélabo—sold Haemaccel's rights in 76 countries, along with its manufacturing facility in Marburg, Germany, to PlasmaSelect AG, a German biopharmaceutical company.^[31]^[32] In 2008, Piramal Healthcare, an Indian pharmaceutical firm, acquired the global Haemaccel brands from PlasmaSelect AG for €7.7 million, securing worldwide marketing rights, regulatory dossiers, and know-how while excluding the Marburg facility; PlasmaSelect handled manufacturing during the transition period. Separately, Piramal had entered the Indian market earlier by purchasing Haemaccel-related business and a Mumbai manufacturing facility from Sanofi-Aventis in 1998. This acquisition positioned Piramal as a leader in polygeline-based plasma expanders, with combined annual revenues from Haemaccel and associated brands reaching €9.1 million at the time.^[32]^[33] Today, Haemaccel is manufactured by Piramal Critical Care Ltd., a subsidiary of Piramal Enterprises, with production shifted to a dedicated facility in Baddi, India; this plant, established post-2008 acquisition, complies with European Directorate for the Quality of Medicines (EDQM) and UK Medicines and Healthcare products Regulatory Agency (UKMHRA) standards, boasting an initial capacity of 4.2 million units annually. The product is marketed under the Haemaccel brand in over 38 countries and as Haemageline in 17 others, with regional variations including Emagel in Italy, Solucel in Venezuela, and Polygeline in China; in certain markets, it is available as generic polygeline.^[32]^[34]^[35] A notable controversy arose between 1998 and 2000, when reports of adverse reactions, particularly anaphylactoid events, increased markedly compared to prior years; investigations attributed this to a change in the manufacturing process implemented around that time. The issue was resolved through process adjustments, including reversion to earlier methods, which restored reaction rates to pre-1998 levels without further incidents linked to production.^[22]

References

[1]
Haemaccel - Summary of Product Characteristics (SmPC) - (emc)
As a plasma volume substitute in the initial treatment of hypovolaemic shock due to: a) Haemorrhage (visible or concealed) b) Burns, peritonitis, pancreatitis, ...
[2]
Haemaccel - an overview | ScienceDirect Topics
Haemaccel is defined as a modified gelatin solution with a molecular weight between 30 and 35 kDa, possessing no oxygen-carrying ability, a half-life of 3 hours ...
[3]
Fluid therapy with Ringer's solution versus Haemaccel ... - PubMed
We conclude that volume therapy with Haemaccel following heart surgery requires less volume and achieves better filling of the circulation compared to Ringer's ...
[4]
Hypovolemia and Hypovolemic Shock - StatPearls - NCBI Bookshelf
Jun 1, 2025 · Hypovolemic shock is a life-threatening condition caused by a significant reduction in blood volume, which prevents the heart from pumping enough blood to meet ...
[5]
HAEMACCEL - Drugs.com
Haemaccel contains sodium chloride and potassium chloride: Haemaccel contains 4.25g sodium chloride & 0.20g potassium chloride per 500ml. This medicinal product ...
[6]
Effectiveness and Safety of Polygeline in Patients with Hypovolemia ...
Polygeline can be safely administered to patients with traumatic injury to improve hemodynamic parameters and achieve stability.
[7]
[PDF] Polygeline in patients with hypovolemia caused by accidental trauma
Mar 7, 2018 · Conclusions: Polygeline was found to be safe and effective in improving hemodynamic stability in patients with hypovolemia due to accidental ...
[8]
Polygeline: a comprehensive review of its role as a plasma volume ...
Jun 27, 2025 · Plasma volume expansion with Haemaccel does not impair haemostasis during reduction mammaplasty. S Afr J Surg. 1998;36(1):22-5. Place of ...
[9]
Paracentesis-Induced Circulatory Dysfunction: A Primer for the ... - NIH
Paracentesis-induced circulatory dysfunction is a complication of large volume paracentesis that leads to faster reaccumulation of ascites, hyponatremia, ...
[10]
[PDF] Hemaccel as a Cheaper Alternative to Human Albumin for Plasma ...
Hemaccel is as effective as albumin in preventing hemodynamic disturbances following large volume paracentesis in patients with cirrhosis and tense ascites, ...
[11]
Randomized comparative study of hemaccel vs. albumin infusion ...
These results indicate that hemaccel infusion may safely replace albumin infusion after total paracentesis for cirrhotic patients with refractory ascites.
[12]
Plasma expanders for people with cirrhosis and large ascites treated ...
Plasma volume expanders are used in connection to paracentesis in people with cirrhosis to prevent reduction of effective plasma volume.
[13]
Polygeline - an overview | ScienceDirect Topics
Polygeline is a plasma volume expander used as a 3.5% solution with electrolytes in the management of hypovolemic shock.Missing: specifications | Show results with:specifications
[14]
Are All Colloids Same? How to Select the Right Colloid?
Polygeline is supplied as a 3.5% solution with electrolytes (Na + 145, K + 5.1, Ca ++ 6.25 & Cl − 145 mmol/l). As polygeline contains calcium ions it can ...
[15]
[PDF] Haemaccel 3.5% w/v solution for infusion - HPRA
Up to 1,500 ml blood loss can be replaced entirely by Haemaccel. For between 1,500 ml and 4,000 ml blood loss, fluid replacement should be with equal volumes of ...
[16]
Plasma volume changes after infusion of various plasma expanders
The plasma volume expansion after infusion of dextran 70 (Macrodex), hydroxyethylstarch (Volex), polygelatin (Haemaccel), albumin and saline was found to be ...Missing: multiple | Show results with:multiple
[17]
Polygeline - PubMed
This half life increases in patients with impaired renal function to about 16 hours. Polygeline is used in the initial management of hypovolaemia where its dose ...
[18]
Haemaccel generic. Price of haemaccel. Uses, Dosage, Side effects
Oct 30, 2015 · Haemaccel dosage. Adult Shock prophylaxis 500-1,500 mL, approx 20 mL/kg/day. Vol-deficiency shock Max: 2,000 mL. In emergencies Vol as ...
[19]
Indian Pediatrics - Editorial
Intervention: Resuscitation with normal saline or polymer from degraded gelatin (Haemaccel®) in the boluses rate of 20 mL/kg till hemodynamic stabilization or ...
[20]
[PDF] Compatibility and stability of polygeline (Haemaccel) with different ...
Plasma substitutes play a key role in fluid therapy in hypovolemia particularly and effectively in intensive care patients and also in emergency (Beards et al.<|control11|><|separator|>
[21]
[Haemaccel 35: adverse reactions in a multicentric, prospective study]
8 patients showed mainly cutaneous reactions (redness and itchy swelling) and only one an increase of ventilating pressure during anaesthesia (0.78%).
[22]
Haemaccel (Polygeline) Reactions: Anaphylaxis or Anaphylactoid?
' Haemaccel is indicated for the prevention and treatment of shock related to the loss of blood, plasma, or water and electrolytes and as a plasma substitute.
[23]
Haemaccel (Polygeline) Reactions: Anaphylaxis or Anaphylactoid?
Aug 10, 2025 · Haemaccel (polygeline) is frequently used as a plasma expander in the critical care setting. Allergic reactions to polygeline occur ...
[24]
https://www.medplusmart.com/product/haemaccel-500ml-iv-inj_haem0002
[25]
Haemaccel : Uses, Side Effects, Interactions, Dosage / Pillintrip
Dosage adjustments for other medications may be necessary depending on your condition and response to Haemaccel infusion. For example, with significant ...
[26]
Are All Colloids Same? How to Select the Right Colloid? - PMC
Polygeline is supplied as a 3.5% solution with electrolytes (Na+ 145, K+ 5.1, Ca++ 6.25 & Cl − 145 mmol/l). As polygeline contains calcium ions it can be ...
[27]
A Clinical Study on Haemaccel - Korean Journal of Anesthesiology
To determine the effects of Haemaccel upon liver, kidney, serum electrolytos and hemostatic functions, 500 ml. of 3.5% Haemaccel solution was administered ...
[28]
Histamine release in human subjects by modified gelatin ... - PubMed
Nine instances of allergic and anaphylactoid reactions to plasma substitutes have been reported, seven after Haemaccel infusion, and two after dextran ...Missing: slow | Show results with:slow
[29]
Cardiac Arrest following Haemaccel - Sage Journals
It it generally believed that the anaphylactoid reactions associated with. Haemaccel are solely due to histamine release and do not have any immunological ...
[30]
Hoechst Aktiengesellschaft | Chemical production, Pharmaceuticals ...
Aventis, former French pharmaceutical company founded in 1999 through the merger of the German firm Hoechst and the French company Rhône-Poulenc.Missing: ownership Deltex Piramal
[31]
[PDF] Piramal Healthcare Acquires Haemaccel Brands Group of ...
Jul 2, 2008 · In 1998, Piramal Healthcare bought Haemaccel-related business in the Indian market along with the manufacturing facility in Mumbai from sanofi- ...Missing: ownership history Hoechst Deltex
[32]
Piramal Health to buy German PlasmaSelect's brands - Reuters
Jul 2, 2008 · The cash deal gives Piramal, formerly called Nicholas Piramal India Ltd, worldwide rights to the products sold under the brand names 'Haemaccel ...Missing: Deltex Group
[33]
Piramal Healthcare buys German co?s brand - The Financial Express
Jul 3, 2008 · Piramal Healthcare has completed a definitive agreement with Plasma, Germany to acquire PlasmaSelect?s polygeline based blood plasma products ...Missing: Deltex | Show results with:Deltex
[34]
NPIL to start commercial production of Haemaccel in Himachal ...
Feb 5, 2013 · Overall, the Baddi facility will see an investment to the tune of Rs 160-170 crore including this facility, he added. The company expects that ...