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Interoception

Interoception is the process by which the nervous system senses, interprets, and integrates signals originating from within the body, including visceral, cardiovascular, respiratory, and gastrointestinal states, to provide a moment-by-moment representation of the body's internal environment.^[1] This sensory modality encompasses both conscious awareness, such as feeling hunger or a racing heartbeat, and unconscious processing that supports homeostasis and emotional regulation.^[2] Originally coined by physiologist Charles Sherrington in 1906 to describe afferent information from internal organs, the concept was revitalized in the early 2000s through neuroscientific frameworks emphasizing its role in integrating bodily signals with cognition and affect.^[1] At its core, interoception involves multiple components: sensing through specialized interoceptors that detect biochemical, mechanical, and thermal changes in organs and tissues; integration in brainstem and cortical regions; interpretation linking these signals to subjective feelings; and regulation via descending neural pathways that modulate bodily responses.^[2] Key neural structures include the nucleus of the solitary tract in the brainstem, which relays afferent signals, and the insula cortex, particularly its posterior-to-anterior gradient, which processes and represents interoceptive information for higher-order functions like decision-making and self-awareness.^[1] These pathways operate across conscious and non-conscious levels, with vagal and spinal afferents conveying information from the viscera to central brain areas such as the amygdala and anterior cingulate cortex, facilitating the brain's bidirectional communication with the body.^[2] Interoception plays a pivotal role in physical and mental health by underpinning homeostasis, emotional experience, and adaptive behavior, with disruptions implicated in various psychopathologies.^[3] For instance, altered interoceptive processing is associated with anxiety disorders, where heightened sensitivity to cardiac signals may exacerbate panic; depression, involving blunted awareness of bodily states; and conditions like autism spectrum disorder, characterized by deficits in integrating internal cues with social emotions.^[1] In clinical contexts, it influences empathy, pain perception, and responses to stress through interactions with the autonomic nervous system and gut-brain axis, highlighting its broader implications for wellbeing and therapeutic interventions such as mindfulness-based practices.^[3] Ongoing research employs techniques like heartbeat detection tasks and functional neuroimaging to quantify interoceptive accuracy, sensibility, and awareness, advancing models of its metacognitive dimensions.^[2]

Fundamentals

Definition and Etymology

Interoception refers to the perception of the internal physiological condition of the body, encompassing signals arising from organs, tissues, metabolic processes, and other visceral activities that contribute to the sense of bodily state.^[4] This sensory modality provides information about homeostatic regulation, such as feelings of hunger, thirst, or the rhythm of the heartbeat, enabling the organism to maintain internal balance.^[4] Unlike exteroception, which involves the detection of external environmental stimuli through senses like vision and hearing, or proprioception, which monitors body position and movement via muscles and joints, interoception is primarily concerned with internal bodily signals that may or may not reach conscious awareness.^[5]^[4] The term "interoceptive" was first introduced by the British neurophysiologist Charles Sherrington in 1906 in his seminal work The Integrative Action of the Nervous System, where he used it to describe sensations originating from the internal surfaces of the body, particularly the viscera, in contrast to exteroceptive sensations from the external surface.^[5] Sherrington derived the adjective from "interior receptor," combining the Latin prefix inter- (meaning internal) with receptor (a sensory receiver), reflecting the focus on afferent signals from within the body.^[5] The noun form "interoception" emerged later in the scientific literature during the 1940s, evolving to encompass a broader construct of internal bodily perception as a product of central nervous system integration.^[5] Interoception involves both conscious and unconscious processing of signals critical for survival and emotional experience, with unconscious aspects primarily supporting autonomic regulation while conscious facets allow subjective feelings of bodily states.^[4] It is often characterized by three interrelated dimensions: interoceptive accuracy, which measures the objective ability to detect internal signals (e.g., via heartbeat counting tasks); interoceptive sensibility, reflecting subjective self-reported awareness and attention to these signals; and interoceptive awareness, a metacognitive component assessing the alignment between one's confidence in detection and actual performance.^[6] These facets highlight interoception's role not just in basic physiological monitoring but also in higher-order self-perception and emotional processing.

Historical Development

The concept of interoception emerged in the early 20th century as part of broader efforts to classify sensory systems. In 1906, Charles Sherrington introduced the term "interoceptive" in his seminal work The Integrative Action of the Nervous System, defining it as the sensing of internal bodily states, particularly visceral sensations, in contrast to exteroceptive perceptions of the external environment.^[7] This distinction built on physiological observations of reflex arcs and nervous integration, marking the first formal recognition of internal sensory processes as a distinct category.^[8] Sherrington's framework emphasized how interoceptive signals contribute to coordinated bodily responses, laying the groundwork for understanding autonomic regulation. Shortly thereafter, in 1907–1908, Henry Head, collaborating with W.H.R. Rivers and others, advanced this area through studies on sensory recovery after nerve injury, proposing the protopathic-epicritic distinction. Protopathic sensibility referred to diffuse, poorly localized sensations often associated with internal or painful stimuli, while epicritic sensibility involved precise, discriminative touch more typical of external senses. This work highlighted the dual nature of somatosensory pathways, with protopathic fibers linked to interoceptive-like visceral afferents, influencing later debates on the qualitative differences between internal and external sensing.^[9] In the late 19th and early 20th centuries, psychological perspectives began integrating interoceptive signals with emotion and homeostasis. William James, in his 1890 Principles of Psychology, argued that emotions consist primarily of the perception of bodily changes, such as visceral arousal, suggesting that feelings arise from awareness of internal physiological states.^[10] This James-Lange theory positioned interoception as central to affective experience, influencing subsequent research on how bodily feedback shapes consciousness. Complementing this, Walter Cannon's 1927 critique of the James-Lange theory introduced the concept of homeostasis, portraying interoceptive signals as essential for monitoring and maintaining internal equilibrium through autonomic nervous system feedback. Cannon's framework emphasized the brain's role in integrating these signals for adaptive regulation, bridging physiology and behavior. From the mid-20th century through the 1990s, research shifted toward neural mechanisms and behavioral measures. Precursors to modern models appeared in 1970s studies of the spinothalamic tract, which identified pathways conveying visceral information to the brain, setting the stage for detailed mapping of interoceptive afferents. A key psychophysiological tool emerged with heartbeat detection tasks in the 1970s, pioneered by researchers like J. Brener and J.M. Jones, enabling quantification of individual differences in cardiac interoceptive sensitivity through self-reported perception of heartbeats.^[11] These methods revealed variability in bodily awareness and its links to anxiety and autonomic control. Culminating this era, A.D. Craig's 2002 synthesis described the lamina I spinothalamic pathway as a dedicated interoceptive conduit from viscera to the insular cortex, unifying disparate findings into a coherent neuroanatomical model. The 2000s marked the rise of neuroimaging techniques, particularly fMRI, which illuminated central processing of interoceptive signals. Early studies, such as those by Hugo Critchley in 2004, demonstrated that anterior insula activation correlates with heartbeat detection accuracy, establishing the insula as a hub for interoceptive awareness. This period saw integration with affective neuroscience, especially post-2009 through collaborations like those of Critchley and Sarah Garfinkel, who explored how interoceptive processing modulates emotional intensity and vulnerability in disorders like anxiety.^[12] These advances shifted focus from peripheral sensing to brain-body interactions in emotion regulation. Key milestones in the 2010s refined conceptual boundaries. In 2015, Sarah N. Garfinkel and colleagues proposed a multidimensional framework for interoception, distinguishing sensory accuracy, subjective awareness, and their metacognitive aspects, facilitating standardized measurement across studies.^[6] Entering the 2020s, research emphasized predictive processing models, where the brain anticipates interoceptive signals to optimize homeostasis, amid heightened interest spurred by COVID-19 studies on altered bodily awareness in survivors. These investigations linked disrupted interoception to persistent symptoms like fatigue and anxiety, underscoring its role in post-viral recovery.^[13] In 2025, a major $14.2 million initiative was launched to map the brain's interoceptive pathways, aiming to deepen understanding of brain-body communication.^[14]

Physiological Systems

Cardiovascular and Respiratory Systems

Interoception in the cardiovascular system primarily involves the detection of blood pressure fluctuations and cardiac rhythm through specialized mechanoreceptors. High-pressure baroreceptors, located in the carotid sinus and aortic arch, sense stretch induced by changes in arterial blood pressure, providing critical feedback for maintaining hemodynamic stability.^[15] These baroreceptors generate pulsatile signals synchronized with the cardiac cycle, which are transmitted as afferent impulses to the central nervous system.^[16] Additionally, heartbeat signals are conveyed via vagal afferents from cardiac mechanoreceptors, enabling the perception of cardiac timing and intensity.^[17] In orthostatic responses, baroreceptors play a pivotal role in the baroreflex, where a sudden drop in blood pressure upon standing triggers rapid adjustments in heart rate and vascular tone to prevent hypotension and syncope.^[15] This reflex arc helps preserve cerebral perfusion during postural changes, highlighting the interoceptive system's contribution to immediate homeostatic corrections.^[18] Respiratory interoception encompasses the sensing of gas levels and mechanical aspects of breathing through distinct receptor populations. Peripheral chemoreceptors in the carotid bodies detect alterations in blood oxygen (O₂), carbon dioxide (CO₂), and pH, initiating ventilatory adjustments to correct hypoxemia or hypercapnia.^[19] Central chemoreceptors, concentrated in the retrotrapezoid nucleus of the medulla oblongata, respond primarily to brain interstitial CO₂ and pH changes, driving increases in respiratory rate and depth during acidosis.^[20] Lung stretch receptors, including slowly adapting pulmonary stretch receptors, monitor lung inflation and contribute to the regulation of breathing rhythm via the Hering-Breuer reflex, which inhibits inspiration upon excessive lung expansion.^[21] These respiratory signals integrate to form the perception of dyspnea, the subjective sensation of breathing discomfort, which arises from mismatched afferent inputs during conditions like hypoxia or airway obstruction.^[22] Dyspnea serves as an interoceptive alarm, prompting behavioral adaptations such as increased respiratory effort.^[22] Signal transduction for both cardiovascular and respiratory interoception relies on cranial nerves that relay sensory data to the brainstem. The vagus nerve (cranial nerve X) carries pulsatile cardiac signals and pulmonary stretch information from the aortic arch, heart, and lungs, while the glossopharyngeal nerve (cranial nerve IX) transmits baroreceptive and chemosensory inputs from the carotid sinus and bodies.^[23] These afferents converge in the nucleus tractus solitarius (NTS) of the medulla, where initial processing occurs before ascending pathways distribute the signals.^[16] In homeostatic functions, these interoceptive signals regulate autonomic balance by modulating sympathetic and parasympathetic outflows, ensuring coordinated cardiovascular and respiratory adjustments to maintain internal equilibrium.^[15] Heart rate variability (HRV), quantified as fluctuations in inter-beat intervals, serves as a key metric of interoceptive signaling integrity, with higher HRV reflecting enhanced vagal tone and better autonomic flexibility.^[24] For instance, individuals with greater HRV demonstrate superior accuracy in detecting their own heartbeats, underscoring HRV's role in interoceptive precision.^[24]

Gastrointestinal, Genitourinary, and Other Systems

Interoceptive signals from the gastrointestinal tract arise primarily from mechanoreceptors and chemoreceptors embedded in the gut wall, which detect mechanical distension associated with fullness and chemical changes linked to nausea or nutrient composition.^[16] These receptors, including low-threshold mechanosensitive endings in the muscular layers, respond to stretch during gastric filling and transmit signals via vagal afferents to convey satiety and digestive status.^[25] Spinal afferents, originating from dorsal root ganglia, complement vagal pathways by relaying similar signals from the lower gut, contributing to the perception of postprandial fullness and aversion to overeating.^[16] In the genitourinary system, bladder distension is sensed by mechanosensitive afferents in the detrusor muscle, which activate as volume increases to signal the urge to void.^[26] These low-threshold stretch receptors, innervated by pelvic and hypogastric nerves, provide graded feedback proportional to filling pressure, enabling conscious awareness of bladder fullness.^[27] Renal osmoreceptors, located in the kidney's juxtaglomerular apparatus and renal nerves, monitor extracellular fluid osmolarity to detect dehydration and hydration status, influencing fluid balance regulation through afferent signaling.^[28] Other interoceptive systems include visceral thermoreceptors that monitor core body temperature deviations, with warm-sensitive neurons in the abdominal viscera responding to hyperthermia and cold-sensitive ones to hypothermia.^[29] Visceral nociceptors, specialized free nerve endings in organ walls, detect inflammatory or ischemic conditions to signal pain, often referred diffusely due to convergent spinal pathways.^[30] Endocrine-related signals, such as glucose levels, are sensed by specialized afferents in the portal vein wall, where vagal nerve endings respond to postprandial glucose excursions to regulate hepatic glucose uptake and appetite.^[31] These signals integrate with central processing to drive motivational states, such as thirst, which is primarily triggered by central osmoreceptor activation in the hypothalamus in response to hyperosmolarity, prompting fluid-seeking behavior to restore homeostasis.^[32] Immune-related inflammation signals, conveyed via cytokine-sensitive visceral afferents, contribute to sickness responses by modulating motivational drive and aversion to maintain energy conservation during infection.^[33]

Sensory and Neural Pathways

Peripheral Sensory Mechanisms

Interoceptive signals originate from specialized peripheral receptors embedded in visceral tissues, which detect internal physiological changes and initiate transmission to the central nervous system. These receptors primarily include free nerve endings, mechanoreceptors, and chemoreceptors located in organs such as the heart, lungs, gastrointestinal tract, and bladder. Free nerve endings, often polymodal nociceptors, respond to multiple stimuli including mechanical distortion, chemical irritants, temperature variations, and itch, thereby integrating diverse sensory information from bodily tissues.^[2] Mechanoreceptors sense stretch or pressure in organ walls, while chemoreceptors monitor biochemical shifts like pH or ion concentrations.^[34] The transmission of these signals occurs via visceral afferent fibers, which differ from somatic afferents in their composition and conduction properties. The majority (over 90%) of vagal visceral afferents are unmyelinated C-fibers, responsible for slow, diffuse transmission of non-painful sensations such as satiety or nausea, whereas the remaining include thinly myelinated Aδ-fibers for faster conduction of sharper signals like acute visceral discomfort.^[35] This predominance of unmyelinated fibers in visceral pathways contrasts with the more myelinated somatic system, enabling a nuanced representation of internal states over precise localization. Polymodal nociceptors within these fibers further contribute by encoding integrated threat signals, such as inflammation-induced pain combined with thermal changes, crucial for protective responses.^[34] At the periphery, these sensory inputs undergo initial integration through local reflex arcs and feedback mechanisms that support homeostasis without immediate central involvement. For instance, the enteric nervous system in the gut processes nutrient and microbial signals via local circuits, facilitating the gut-brain axis through vagal afferents to modulate digestion and feeding behaviors.^[2] Efferent feedback loops, involving parasympathetic and sympathetic outflows, reciprocally adjust organ function in response to afferent inputs, maintaining physiological balance such as blood pressure or gastrointestinal motility. These peripheral processes briefly interface with broader homeostatic regulation by fine-tuning autonomic responses.^[36] Evolutionarily, the core peripheral mechanisms of interoception are highly conserved across mammals, reflecting their fundamental role in survival through monitoring vital functions like cardiorespiratory status. This conservation is evident in shared receptor types and afferent fiber profiles from rodents to primates. In humans, vagal tone—manifested in heart rate variability—supports advanced social and emotional regulation, building on these ancient pathways.^[37]

Ascending Neural Pathways

The ascending neural pathways for interoception primarily convey signals from peripheral visceral and somatic sensors through the spinal cord and brainstem to thalamic relay nuclei, enabling the central nervous system to monitor and regulate internal bodily states. These pathways integrate multimodal information, including nociceptive, thermal, and autonomic signals, distinguishing them from exteroceptive routes by their focus on homeostatic maintenance rather than external environmental cues. Key routes include the spinothalamic tract and vagal projections, which differ in their anatomical trajectories and functional emphases.^[38] The lamina I spinothalamic tract originates from projection neurons in the superficial dorsal horn (lamina I) of the spinal cord, where Aδ and unmyelinated C fibers from visceral and somatic afferents synapse, carrying signals related to pain, temperature, and certain visceral sensations directly to the thalamus. This pathway is crucial for transmitting multimodal interoceptive information, such as thermal and nociceptive inputs from internal organs, via the anterolateral funiculus of the spinal cord. Studies highlight its role in relaying these signals to posterior thalamic nuclei, supporting basic sensory discrimination of internal states.^[38] Visceroceptive pathways, particularly those mediated by vagal afferents, provide a parallel route for interoceptive signaling from thoracic and abdominal viscera. Vagal sensory neurons in the nodose ganglion project to the nucleus tractus solitarius (NTS) in the medulla, where they relay information on gastrointestinal, cardiovascular, and respiratory states using glutamatergic transmission. From the NTS, second-order neurons ascend to the parabrachial nucleus in the pons, which serves as a critical relay for visceral afferents before projecting to the thalamus and other brainstem targets, facilitating rapid homeostatic adjustments.^[38] Somatosensory contributions to interoception occur via secondary pathways, such as the dorsal column-medial lemniscus system, which carries some overlapping cutaneous and visceral signals from low-threshold mechanoreceptors. Although primarily associated with touch and proprioception, certain visceral afferents, including those from splanchnic nerves, project to the dorsal column nuclei, providing subtle integration of superficial and deep sensory inputs for comprehensive bodily awareness. This route is less dominant for pure interoception but supports boundary perceptions between skin and internal states.^[39]^[40] These pathways exhibit specificity along homeostatic and affective dimensions, where homeostatic signals—such as those from baroreceptors or osmoreceptors—prioritize physiological regulation through NTS and parabrachial routes, while affective dimensions involve nociceptive and emotional salience conveyed via spinothalamic projections to limbic-associated thalamic areas. Recent 2020s research has updated understanding of lamina V projections, revealing their role in autonomic integration; neurons in lamina V of the spinal cord receive convergent visceral and somatic inputs, enabling local reflex arcs to the intermediolateral cell column for sympathetic outflow and ascending projections via the spinothalamic tract for broader interoceptive processing.^[41]^[39]^[40] Thalamic nuclei, such as the posterior and ventroposterior lateral regions, act as final relays for these ascending signals before cortical dissemination.^[38]

Central Processing

Thalamic and Insular Processing

Interoceptive signals from peripheral afferents, primarily via the spinothalamic tract, are relayed through specific thalamic nuclei to initiate central processing.^[42] The ventral medial posterior (VMpo) and ventral medial basal (VMb) nuclei of the thalamus function as key relays for visceral inputs, contributing to the initial subcortical integration of interoceptive information en route to cortical regions, distinct from the ventral posterolateral (VPL) nucleus's primary role in somatosensory processing.^[42] Additionally, intralaminar thalamic nuclei, including posterior groups, contribute to arousal and broad integration of autonomic signals in homeostatic regulation.^[42] The parvocellular part of the ventral posteromedial nucleus (VPMpc), within the ventral medial complex, specializes in processing certain visceral and gustatory afferents, providing a dedicated pathway for interoceptive representation.^[43] These thalamic structures project primarily to the insular cortex, where interoceptive signals undergo hierarchical processing. The granular posterior insula acts as the primary sensory mapping region, receiving direct thalamic inputs to form a topographic representation of bodily states such as cardiorespiratory and gastrointestinal sensations.^[44] This area encodes raw interoceptive data in a manner analogous to primary sensory cortices for exteroception.^[45] Moving anteriorly, the dysgranular mid-insula integrates these primary signals with contextual information, enabling the synthesis of multisensory interoceptive experiences.^[46] The insular cortex exhibits a distinct cytoarchitectonic progression that underlies its functional specialization in interoception. Posterior regions are predominantly granular, characterized by well-defined layer IV and dense cellular packing suited for sensory relay.^[47] This transitions to the dysgranular mid-insula, with reduced granularity and increased connectivity for associative processing, and further to the agranular anterior insula, which lacks a prominent layer IV and supports higher-order executive functions.^[47] This gradient reflects an evolutionary adaptation for escalating complexity in interoceptive handling, from basic sensation to predictive regulation.^[48] Functional neuroimaging studies from the 2010s have established the insula as a central hub for interoceptive processing, with robust connectivity to autonomic centers such as the brainstem and hypothalamus.^[49] Functional MRI evidence demonstrates that posterior insular activation correlates with direct interoceptive stimuli, while mid- and anterior regions show graded involvement in integrating these signals for predictive coding.^[50] The insula's role extends to generating allostatic predictions, where anterior portions anticipate bodily needs and adjust autonomic responses preemptively, minimizing prediction errors in homeostatic maintenance.^[51] This predictive function underscores the insula's position as an integrative nexus, linking thalamic relays to broader neural networks for adaptive interoception.^[52]

Cingulate and Somatosensory Integration

The anterior cingulate cortex (ACC) plays a pivotal role in integrating interoceptive signals with cognitive processes, particularly through its midcingulate region, which facilitates conflict monitoring and error detection in contexts involving bodily states.^[2] This function allows the midcingulate cortex to evaluate discrepancies between expected and actual internal physiological conditions, such as autonomic fluctuations during demanding tasks, thereby supporting adaptive behavioral adjustments.^[53] For instance, during tasks requiring sustained attention, heightened interoceptive awareness in the midcingulate contributes to error detection and performance optimization by signaling bodily discomfort or arousal mismatches.^[54] In contrast, the subgenual region of the ACC is primarily involved in affective valuation, where it processes interoceptive inputs to appraise emotional significance and regulate responses to internal states.^[55] This area modulates the hedonic tone of bodily sensations, influencing how visceral signals contribute to mood and motivational states, as evidenced by its hyperactivity in response to stress-related interoceptive perturbations that alter cortisol dynamics and emotional reactivity.^[56] Such valuation mechanisms enable the subgenual ACC to weigh the affective costs and benefits of internal signals, bridging physiological homeostasis with subjective emotional experience. The somatosensory cortices, including primary (S1) and secondary (S2) areas, extend into the parietal operculum to integrate interoceptive signals with body schema representation, facilitating a unified perception of internal bodily states.^[57] This integration occurs through cross-modal interactions with exteroceptive inputs, where parietal opercular regions process tactile and visceral afferents to refine spatial and temporal aspects of the body schema, as demonstrated in illusions that combine cardiac signals with visual cues to modulate somatosensory activity.^[58] These extensions ensure that interoceptive information, such as from mechanoreceptors in viscera, is calibrated against external sensory data for coherent self-perception. Network dynamics between the cingulate and somatosensory regions reveal overlaps with the default mode network (DMN), where the pregenual ACC and insula contribute to internally directed interoceptive processing during rest or self-referential thought.^[2] Recent diffusion tensor imaging studies from the 2020s have highlighted enhanced white matter tract integrity linking the insula to the ACC, supporting efficient propagation of interoceptive signals across these associative networks and underscoring their role in cognitive flexibility.^[59] These integrative processes underpin adaptive functions in decision-making under bodily uncertainty, where interoceptive cues, often termed "gut feelings," inform risk assessment by providing intuitive signals of physiological mismatch.^[60] For example, individuals with superior interoceptive accuracy exhibit better performance in high-stakes financial trading, leveraging subtle visceral signals to navigate ambiguous risks without explicit reasoning.^[60] This mechanism enhances survival-oriented choices by incorporating bodily uncertainty into probabilistic evaluations, as seen in scenarios requiring rapid judgments amid internal variability.^[61]

Interoception in Emotion and Awareness

Role in Emotional Experience

Interoceptive signals play a central role in the generation of emotions by providing bodily feedback that constitutes the subjective experience of feeling states. The James-Lange theory, originally proposed in the late 19th century, posits that emotions arise from the perception of physiological changes, such as accelerated heartbeat during fear, rather than preceding them.^[62] This perspective has experienced a revival in contemporary interoception research, where bodily sensations are viewed as integral to emotional constitution, integrating peripheral signals to form the core of affective experience.^[63] For instance, the perception of visceral arousal, like increased heart rate, is interpreted as the emotion itself, emphasizing how interoception bridges physiological responses and emotional phenomenology.^[64] Building on this, Antonio Damasio's somatic marker hypothesis (1994) further elucidates interoception's influence on emotion by proposing that bodily states associated with past emotional experiences serve as "somatic markers" to guide value-based decision-making. These markers, derived from interoceptive cues such as gut feelings or autonomic shifts, bias choices toward advantageous outcomes by evoking emotional valence without full conscious deliberation.^[65] In this framework, emotions are not mere byproducts but active regulators, with interoceptive signals from the body reinforcing or inhibiting behavioral responses in complex social and decision contexts.^[66] At the neural level, the anterior insula and anterior cingulate cortex (ACC) form a critical circuit for binding interoceptive inputs to emotional processing, with the amygdala providing modulation for affective intensity. The anterior insula integrates visceral signals to generate emotional awareness, relaying them to the ACC for cognitive evaluation and response selection.^[67] Amygdala inputs to this circuit enhance the salience of interoceptive signals during threat or reward, facilitating rapid emotional binding that underlies adaptive behaviors.^[68] This network's activity overlaps during interoceptive tasks and emotional elicitation, underscoring its role in translating bodily states into felt emotions.^[69] Empirical evidence from biofeedback studies demonstrates that manipulating heartbeat perception can alter emotional experiences, supporting interoception's regulatory function. For example, training individuals to enhance cardiac awareness via biofeedback leads to improved control over autonomic responses during emotional provocation, reducing intensity in negative states like anger.^[70] Similarly, greater heartbeat perception accuracy correlates with heightened emotional intensity, indicating that precise interoceptive processing amplifies affective outcomes.^[71] Cultural variations further highlight this role, as studies have reported differences in interoceptive accuracy for cardiac signals between East Asian and Western individuals, with mixed findings across populations; for instance, one study found higher accuracy in Japanese compared to Belgian participants.^[72] These differences suggest that sociocultural norms shape the interoceptive-emotional link, with implications for cross-cultural emotional regulation.^[73]

Interoceptive Awareness and Subjectivity

Interoceptive sensibility refers to the subjective perception and self-reported intensity of interoceptive signals, distinct from objective measures of accuracy. This dimension captures how individuals attend to and interpret their internal bodily states, often assessed through validated questionnaires that emphasize metacognitive aspects such as noticing, trusting, and emotional response to sensations. A prominent tool for this evaluation is the Multidimensional Assessment of Interoceptive Awareness (MAIA), a 32-item scale developed in 2012 that measures eight facets of interoceptive awareness, including noticing bodily sensations, not distracting attention from them, and emotional awareness of discomfort. The MAIA has demonstrated strong psychometric properties, with high internal consistency (Cronbach's α ranging from 0.64 to 0.86 across scales) and test-retest reliability, making it widely used in research to quantify individual differences in subjective interoception.^[74] A key distinction in interoceptive research lies between accuracy and awareness, highlighting a potential dissociation where self-perceived sensitivity does not always align with objective performance. Interoceptive accuracy is typically measured through behavioral tasks, such as the heartbeat counting paradigm, where participants estimate the number of their heartbeats over a fixed interval without external cues, yielding scores based on deviation from actual counts (e.g., mean absolute error). In contrast, interoceptive awareness encompasses metacognitive elements like confidence in one's judgments or subjective ratings of signal intensity, often showing weak or no correlation with accuracy scores (r ≈ 0.10-0.20). This dissociation is evident in studies where high-confidence errors occur, suggesting that awareness reflects attentional biases or beliefs rather than perceptual fidelity, as demonstrated in experiments comparing heartbeat tracking performance with post-task confidence ratings. Individual differences in interoceptive awareness are influenced by demographic and experiential factors. Sex differences reveal that women generally report higher interoceptive sensibility, with elevated scores on scales like the MAIA (effect size d ≈ 0.3-0.5), potentially linked to greater attention to bodily signals in emotional contexts, though accuracy on objective tasks shows mixed results with no consistent female advantage. Aging is associated with declines in interoceptive accuracy, particularly in heartbeat detection tasks, where performance worsens progressively from young adulthood (correlation r = -0.35 with age), attributed to reduced neural sensitivity in afferent pathways rather than motivational changes. Mindfulness training, conversely, enhances both sensibility and awareness; brief interventions (e.g., 5-day programs) increase MAIA scores across multiple subscales (e.g., +0.5-1.0 standard deviations in noticing and non-distressing), fostering greater attentional allocation to interoceptive cues without altering physiological baselines.^[75]^[76] Philosophically, interoceptive awareness ties into phenomenological accounts of embodiment, where subjective bodily sensations ground the lived experience of selfhood and agency in first-person perspective. In phenomenology, interoception contributes to the pre-reflective sense of embodiment, enabling a felt unity of body and mind that underpins intentionality and emotional qualia, as explored in frameworks emphasizing the lived body (Leib) over objectified anatomy. Recent 2020s research extends this to conditions like aphantasia, characterized by absent voluntary mental imagery, which correlates with reduced interoceptive sensibility and bodily imagery vividness (e.g., lower MAIA emotional awareness scores, d ≈ 0.8), suggesting impaired integration of internal signals into self-referential representations.^[77]^[78]

Clinical and Health Implications

Associations with Mental Disorders

Interoception plays a significant role in the pathophysiology of various mental disorders, with alterations in interoceptive processing contributing to symptom maintenance and emotional dysregulation across psychiatric conditions. Dysfunctions in sensing and interpreting internal bodily signals, such as heartbeat or gastrointestinal sensations, have been linked to heightened vulnerability in anxiety, mood, eating, and neurodevelopmental disorders, often involving imbalances in neural regions like the insula and anterior cingulate cortex (ACC). In anxiety disorders, including generalized anxiety disorder (GAD) and panic disorder, individuals often exhibit heightened interoceptive sensibility, characterized by increased attention to and amplification of benign bodily signals. For instance, in panic disorder, catastrophic misinterpretation of cardiac sensations as threats can trigger acute anxiety episodes, perpetuating a cycle of fear and avoidance.^[79] A meta-analysis of 71 studies found a moderate positive association between self-reported interoceptive awareness and anxiety symptoms, suggesting that subjective hypersensitivity to internal cues exacerbates worry and autonomic arousal in GAD.^[80] This heightened processing is supported by neuroimaging evidence of insula hyperactivity during interoceptive tasks in anxiety patients.^[81] Mood disorders, such as major depressive disorder (MDD) and posttraumatic stress disorder (PTSD), are associated with blunted interoceptive accuracy, impairing the ability to accurately detect internal states like heart rate. In MDD, a systematic review of 6 studies demonstrated significantly reduced cardiac interoceptive accuracy compared to healthy controls, with moderate effect sizes (Cohen's d ≈ 0.5–1.3) that correlate with the intensity of positive affect.^[82] For PTSD, ACC hyperactivity during emotional processing reflects dysregulated integration of interoceptive signals with trauma-related cues, contributing to hypervigilance and re-experiencing symptoms.^[83] These alterations may underlie emotional numbing and avoidance in mood disorders. Eating disorders, particularly anorexia nervosa (AN), involve impaired interoceptive accuracy and sensitivity, with difficulties perceiving internal signals such as hunger or satiety, contributing to the suppression of intake and reinforcement of restrictive behaviors through attenuated awareness and maladaptive reliance on exteroceptive cues.^[84] Functional MRI meta-analyses reveal altered insula activation in AN during interoceptive tasks, linking this over-attunement to body image distortions and weight preoccupation.^[85] In neurodevelopmental disorders like autism spectrum disorder (ASD), reduced interoceptive awareness is common, often tied to insula hypoactivation and difficulties in integrating bodily signals with social-emotional cues. Reviews indicate that individuals with ASD exhibit lower accuracy in heartbeat detection tasks, correlating with alexithymia and challenges in emotional self-regulation.^[86] This hypoactivation in the insula disrupts the subjective experience of internal states, contributing to sensory processing differences.^[87] Meta-analyses highlight interoception as a transdiagnostic factor across DSM-5 categories. A 2019 systematic review by Eggart et al. synthesized evidence of impaired interoceptive accuracy in MDD, while broader transdiagnostic work, including a 2024 review, confirms consistent alterations in anxiety, depression, and psychosis, with effect sizes ranging from small to moderate.^[82] Recent 2023-2025 updates on obsessive-compulsive disorder (OCD) emphasize heightened interoceptive sensibility in compulsions, where sensory phenomena like discomfort from incomplete actions drive repetitive behaviors, supported by systematic reviews linking insula dysfunction to OCD symptom severity.^[88]^[89] These findings underscore interoception's role in unifying mechanisms across disorders.

Links to Physical and Neurological Conditions

Interoceptive dysfunction plays a significant role in chronic pain conditions such as fibromyalgia, where amplified nociceptive signals arise through central sensitization mechanisms. In fibromyalgia syndrome (FMS), patients exhibit heightened interoceptive processing, leading to increased sensitivity to internal bodily signals that exacerbate pain perception.^[90] Central sensitization in FMS involves enhanced neural responsiveness in the central nervous system, amplifying interoceptive inputs from nociceptors and contributing to widespread pain and fatigue.^[91] This altered interoception correlates with emotional factors, where predictive interoceptive models link pain intensity to distorted awareness of bodily states.^[92] Neurological disorders further illustrate interoceptive impairments through specific brain lesions and dysregulations. Stroke-induced lesions in the insula can result in pain asymbolia, a condition where patients detect painful stimuli but lack the appropriate emotional or affective response, disrupting the integration of sensory and interoceptive signals.^[93] In Parkinson's disease, autonomic dysregulation manifests as impaired interoceptive processing of visceral signals, contributing to symptoms like orthostatic hypotension and gastrointestinal issues due to disrupted neural pathways in the brainstem and insula.^[94] These deficits highlight the insula's critical role in modulating interoceptive awareness of autonomic functions.^[95] Beyond these, aphantasia involves impaired mental simulation of bodily states, linked to reduced interoceptive precision and weakened integration of physiological signals with cognitive imagery. Individuals with aphantasia show diminished insula-anterior cingulate cortex connectivity, which hampers the simulation of internal sensations and affects embodied cognition.^[96] In post-COVID long-haul syndrome, persistent respiratory symptoms such as dyspnea persist despite normal pulmonary function, suggesting altered interoceptive perception that heightens symptom awareness through dysregulated signaling in cardiorespiratory networks.^[97] Recent evidence from 2022 studies on multiple sclerosis (MS) demonstrates interoceptive alterations contributing to fatigue and balance issues, with randomized trials showing that interoceptive training improves postural stability by enhancing awareness of bodily signals.^[98] Biomechanical models of altered interoceptive signaling, particularly in chronic pain, incorporate computational frameworks to explain how disrupted afferent pathways lead to maladaptive predictions of internal states, perpetuating symptom cycles.^[99] These models emphasize hierarchical inference processes where imprecise interoceptive signals amplify perceived discrepancies in bodily homeostasis.^[100]

Theoretical Frameworks

Predictive Processing Models

Predictive processing models conceptualize interoception as a form of active Bayesian inference, where the brain generates top-down predictions about internal bodily states to minimize prediction errors arising from sensory inputs. These models, rooted in the free energy principle, posit that interoceptive signals are not passive representations but hypotheses shaped by prior expectations, enabling the brain to reduce uncertainty and surprise in maintaining allostasis—the proactive regulation of physiological stability. Seminal frameworks emphasize hierarchical generative models in which descending predictions from higher cortical regions interact with ascending interoceptive afferents, particularly via the insula, to refine internal models of the body's state.^[101] A key contribution is the Embodied Predictive Interoception Coding (EPIC) model, which integrates anatomical corticocortical connectivity with Bayesian active inference to describe how agranular visceromotor cortices, such as the anterior insula and anterior cingulate cortex, issue predictions about visceral states that are updated by prediction errors from granular sensory cortices.^[102] In this framework, interoceptive experiences emerge from minimizing surprise through iterative adjustment of predictions or autonomic actions, rather than direct readout of bodily signals. Complementing this, Seth and Friston's active interoceptive inference model extends the free energy principle to allostasis, where interoception serves to bound uncertainty in energy regulation by treating bodily states as probabilistic inferences. Here, the brain minimizes variational free energy as a proxy for surprise, with prediction errors computed as the discrepancy between sensory input s and model-based predictions \mu, formalized as:

\delta = s - \mu

This error signal drives perceptual updating or behavioral interventions to align the body with predictions.^[101]^[103] Empirical support for these models comes from active inference simulations of multisensory illusions, such as the interoceptive rubber-hand illusion, where synchronous cardio-visual feedback induces ownership of a virtual hand by resolving prediction errors between exteroceptive and interoceptive signals, mirroring how the brain integrates bodily predictions. Functional MRI studies further implicate the insula as a central hub for predictive interoception, showing its strong connectivity with the anterior cingulate in modeling internal states during rest, consistent with hierarchical error minimization across the allostatic-interoceptive system.^[104]^[52] Critiques of predictive processing models highlight an overemphasis on top-down predictions at the expense of bottom-up sensory drives, as evidenced by fMRI dissociations where thalamic networks support stimulus-dependent interoceptive processing, while amygdalar pathways modulate model-dependent aspects.^[105] Recent extensions in 2024 address this by incorporating multisensory integration, demonstrating how synchronous visuo-tactile and interoceptive feedback in virtual environments enhances bodily self-consciousness through refined predictive coding that balances top-down and bottom-up signals in the rubber-hand paradigm.^[106]

Embodied and Integrative Theories

Embodied cognition theories posit that higher-level mental processes, including abstract thought, are grounded in perceptual, motor, and interoceptive simulations derived from bodily states. In this framework, interoception serves as a critical mechanism for anchoring conceptual representations in the internal milieu, allowing bodily signals such as heartbeat or visceral sensations to inform and shape cognitive operations. For instance, Lawrence Barsalou's perceptual symbols theory emphasizes that concepts are not amodal but arise from multimodal simulations, including interoceptive experiences that integrate internal physiological states with external perceptions to facilitate understanding of abstract ideas like emotions or values.^[107] This grounding role of interoception underscores how bodily awareness contributes to the simulation of situated actions, enabling cognition to be inherently tied to the organism's physical and internal dynamics rather than isolated symbolic processing.^[108] Ecological approaches extend James J. Gibson's affordance theory—originally focused on environmental opportunities for action—to the internal bodily domain, framing interoception as the perception of "internal affordances" that guide adaptive responses to physiological needs within the body's milieu. These perspectives view interoceptive signals not merely as passive inputs but as active invitations for organism-environment interactions, where bodily states offer possibilities for regulation and homeostasis akin to external action opportunities. Recent ecological models of interoception propose an affective spectrum of embodied experiences, integrating interoceptive awareness with the broader ecological context of being-in-the-world, thereby emphasizing how internal sensations dynamically shape self-perception and environmental engagement.^[109]^[77] Integrative theories within the 4E cognition paradigm—encompassing embodied, embedded, enactive, and extended dimensions—apply these principles to interoception by highlighting its role in whole-body integration and social processes. Interoception is seen as foundational to embodied selfhood, where internal signals enact cognitive processes through dynamic interactions with the environment and others, extending beyond individual physiology to influence extended social cognition. In particular, social interoception facilitates empathy by enabling the sharing and simulation of others' bodily states, allowing individuals to attune to interpersonal cues and co-regulate affective experiences.^[110] For example, heightened interoceptive awareness enhances neural responses in empathy-related networks, supporting perspective-taking and emotional resonance in social interactions.^[111] Recent developments in integrative theories include the concept of social allostasis, which posits that interpersonal interactions regulate bodily predictions and energy balance through shared interoceptive mechanisms, linking social cues to internal predictive adjustments for collective homeostasis. This model builds on earlier somatovisceral afference frameworks by emphasizing how touch and social touch, in particular, mediate allostatic processes via interoceptive pathways, fostering emotional construction and social bonding.^[112] Such approaches unify interoception within broader 4E frameworks, illustrating its enactive role in social dynamics and adaptive integration across individual and collective levels.

Assessment and Interventions

Measurement Methods

Interoceptive accuracy, which refers to the objective ability to perceive internal bodily signals, is commonly assessed through behavioral tasks such as the heartbeat detection paradigm developed by Schandry. In this method, participants silently count their heartbeats over intervals of varying lengths (typically 25, 35, 45, or 100 seconds) without external cues, and accuracy is calculated as the proportion of correctly estimated heartbeats compared to the actual number recorded via electrocardiography (ECG). The standard formula for interoceptive accuracy (IAcc) across n trials is IAcc = (1/n) ∑ [1 - (|n_i - r_i| / n_i)], where n_i is the actual number of heartbeats in trial i and r_i is the participant's reported count; scores range from 0 (no accuracy) to 1 (perfect accuracy), with typical healthy adult means around 0.65–0.80. This task distinguishes interoceptive accuracy from sensibility (subjective perception) and has been widely adopted due to its simplicity and reliability, though it primarily targets cardiac signals.^[113]^[114] Subjective measures of interoceptive sensibility and awareness, which capture self-reported perceptions of bodily states, rely on validated questionnaires. The Body Perception Questionnaire (BPQ), developed by Porges, assesses awareness of bodily sensations, autonomic reactivity, stress responses, and related health attitudes through 122 items rated on a 5-point Likert scale, yielding subscale scores for dimensions like respiratory and cardiac awareness. Complementing this, the Interoceptive Accuracy Scale (IAS) evaluates metacognitive beliefs about one's ability to accurately detect interoceptive signals (e.g., hunger, heartbeat) independently of attention focus, using 21 items on a 5-point scale; higher scores indicate greater perceived accuracy, with good internal consistency (α ≈ 0.80) and discriminant validity from related constructs like alexithymia. These tools provide insights into trait-like differences in interoceptive processing, often correlating moderately with objective tasks (r ≈ 0.20–0.40).^[115]^[116] Neuroimaging techniques offer objective neural correlates of interoception by examining brain activation during tasks. Functional magnetic resonance imaging (fMRI) frequently reveals activation in the insula, particularly the posterior and mid-insula, during heartbeat detection or respiratory tracking, reflecting the integration of visceral signals; for instance, higher interoceptive accuracy associates with greater insula BOLD signal in response to cardiac cues. Electroencephalography (EEG) measures evoked potentials, such as heartbeat-evoked potentials (HEPs) or respiratory-related evoked potentials (RREPs), to assess sensory gating; reduced RREP amplitude in the second of paired stimuli indicates effective neural filtering of respiratory signals, linking to interoceptive precision in anxiety contexts. These methods highlight the insula's role as a hub but require controlling for confounds like motion artifacts.^[117]^[118] Recent advances include virtual reality (VR) paradigms that simulate multisystem interoceptive experiences, such as integrating cardiac, respiratory, and gastrointestinal cues in immersive environments to enhance ecological validity over traditional tasks. A 2023 VR protocol, for example, uses guided attention to bodily signals in virtual scenarios to probe awareness across modalities, showing improved engagement and sensitivity detection compared to static methods. However, validity challenges persist, including demand characteristics where participants may guess or conform to expected heartbeat patterns, inflating scores via top-down expectations rather than true perception; studies recommend signal detection adaptations to mitigate this.^[119]^[120]

Therapeutic and Research Applications

Interventions targeting interoception have shown promise in enhancing bodily awareness and managing stress-related conditions. Mindfulness-Based Stress Reduction (MBSR) programs, which emphasize non-judgmental attention to internal sensations, have been found to improve interoceptive awareness, particularly when supplemented with tools like smartwatches for real-time monitoring of physiological signals.^[121] Adapted versions of MBSR, such as those focused on blood pressure reduction, further bolster interoceptive sensibility and adherence to healthy behaviors in clinical populations.^[122] Similarly, heart rate variability (HRV) biofeedback training enables individuals to voluntarily regulate autonomic responses, thereby reducing anxiety symptoms by refining interoceptive processing and promoting cardiac coherence.^[123] This approach has demonstrated efficacy in lowering trait anxiety through repeated sessions that enhance awareness of internal bodily states.^[124] Clinical trials have increasingly incorporated interoceptive elements into established therapies for anxiety and mood disorders. Interoceptive exposure therapy, a core component of cognitive-behavioral therapy for panic disorder, involves deliberate induction of bodily sensations to reduce fear responses, with meta-analyses indicating it as a key predictor of symptom reduction across various CBT formats.^[125] For instance, successful exposure-based interventions have been shown to decrease defensive reactivity to interoceptive threats in patients with panic disorder.^[126] In depression treatment, transcutaneous auricular vagus nerve stimulation (taVNS) devices modulate interoceptive sensitivity by influencing vagal pathways, leading to rapid improvements in mood through enhanced awareness of internal signals.^[127] Such neuromodulation techniques provide a non-invasive means to target interoceptive deficits associated with affective disorders.^[128] Ongoing research frontiers explore computational and developmental aspects of interoception to inform future interventions. Artificial intelligence models, inspired by biological systems, simulate interoceptive networks to predict internal state dynamics, offering tools for personalized therapeutic simulations in mental health.^[129] Machine learning approaches have also classified interoceptive traits from training data, aiding in the differentiation of sensibility levels for targeted interventions.^[130] Longitudinal studies post-2020 have revealed age-related declines in cardiac interoceptive sensitivity, particularly under perturbation, highlighting the need for interventions to mitigate sensory processing changes in older adults.^[131] Recent investigations into psychedelics, such as psilocybin, indicate they induce altered interoceptive states by enhancing subjective awareness of bodily signals and autonomic balance, potentially reopening therapeutic windows for conditions involving disrupted interoception.^[132] These findings underscore emerging directions in integrating neuroplasticity and predictive modeling to address interoceptive gaps in aging and psychiatric care.

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(PDF) Allostasis, interoception, and the free energy principle
Nov 26, 2019 · Allostasis describes how the organism remains stable in the face of change, via regulatory mechanisms that ensure the independence of the ...
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https://www.researchgate.net/publication/320677836_Allostasis_interoception_and_the_free_energy_principle_Feeling_our_way_forward
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Interplay between top-down and bottom-up processing - PubMed
Bottom-up processing is stimulus-dependent, while top-down is model-dependent. A left thalamus network is linked to bottom-up, and a left amygdala network to ...
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Enhancing bodily self-consciousness in the virtual world with ...
Suzuki et al. Multisensory integration across exteroceptive and interoceptive domains modulates self-experience in the rubber-hand illusion. Neuropsychologia.
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Grounded cognition - PubMed
Grounded cognition rejects traditional views that cognition is computation on amodal symbols in a modular system, independent of the brain's modal systems ...
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Embodied cognition and beyond: Acting and sensing the body
As Barsalou (2008) states, “Grounded cognition reflects the assumption that cognition ... interoceptive, metacognitive, social, and linguistic experience.
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[PDF] J.J. Gibson – Affordances - Brown CS
The affordances of the environment are what it offers the animal, what it provides or furnishes, either for good or ill. The verb to afford is found in the ...Missing: inference internal
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An Embodied Cognition Perspective on the Role of Interoception in ...
Oct 11, 2021 · In this perspective, we extend the embodiment account of interoceptive inference to explain the development of the minimal self in humans.
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Interoception and Empathy Impact Perspective Taking - PMC
Jan 18, 2021 · Recent work suggests that interoceptive signals not only contribute to own-body perception and self-consciousness, but also to empathy.
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Social Interoception and Social Allostasis through Touch: Legacy of ...
Here we compare how the SAME and the more recent Theory of Constructed Emotion (TCE) view the role of interoceptive signals in creating emotional experiences.
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Heart beat perception and emotional experience - PubMed
Heart beat perception and emotional experience. Psychophysiology. 1981 Jul;18(4):483-8. doi: 10.1111/j.1469-8986.1981.tb02486.x. Author. R Schandry. PMID ...Missing: method detection paper
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Methodological Recommendations for a Heartbeat Detection-Based ...
Heartbeat detection tasks are often used to measure cardiac interoceptive sensitivity: the ability to detect sensations from one's heart.
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Body Perception Questionnaire (c)1993
The BODY PERCEPTION QUESTIONNARIE has five sub-tests: 1) Awareness, 2) Stress Response, 3) Autonomic Nervous System Reactivity, 4) Stress Style, and 5) Health ...
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Interoceptive Accuracy Scale
The Interoceptive Accuracy Scale (IAS) is a self-report assessing the independence of perceived interoceptive accuracy and attention, relating to bodily ...
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Keeping the body in mind: Insula functional organization and ...
A map of how interoceptive, exteroceptive, and emotional awareness are integrated within the insular cortex.
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Respiratory sensory gating measured by respiratory-related evoked ...
The respiratory-related evoked potential (RREP) is a useful non-invasive electrophysiological method for studying the effects of anxiety on respiratory ...
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Inward VR: Toward a Qualitative Method for Investigating ...
May 1, 2023 · We report results from a first exploratory study (n=21) applying this method to understand the interoceptive experiences of users in a VR environment.Missing: paradigms multisystem
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Expectation predicts performance in the mental heartbeat tracking task
The mental heartbeat tracking task by Schandry is sensitive to non-interoceptive (top-down) influences, e.g., estimation of heart rate and expectation.
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Mindfulness-based stress reduction training supplemented with ...
The results suggest that supplementing MBSR with monitoring interoceptive signals by a smartwatch enhances mindfulness, and maintains the effect of stress and ...
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Adapted Mindfulness Training for Interoception and Adherence to ...
Nov 2, 2023 · Overall, the findings of this phase 2 RCT showed that the MB-BP program improved interoceptive awareness compared with an enhanced usual care ...
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The Utility of Heartrate and Heartrate Variability Biofeedback ... - MDPI
We propose a three-stage model by which HR(V)-BF may improve interoception which draws upon principles of interoceptive inference and predictive coding.<|separator|>
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Effects of Heart Rate Variability Biofeedback Training on Anxiety ...
Jun 18, 2024 · This study examined the anxiety-reducing effects of HRVBF training and related brain activity changes by randomly assigning participants, employing an active ...
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Remote cognitive behavioral therapy for panic disorder: A meta ...
A recent meta-analysis comparing each of the key CBT components in treating PD found that interoceptive exposure was an important predictor of symptom ...
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Decreased defensive reactivity to interoceptive threat after ... - Nature
Mar 17, 2021 · Decreased defensive reactivity to interoceptive threat after successful exposure-based psychotherapy in patients with panic disorder.Results · Heart Rate And Skin... · Defensive Reflex...
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Non-invasive vagus nerve stimulation conditions increased ...
Sep 29, 2023 · Therefore, alterations in interoception that have been recently linked to depression might provide a mechanism for taVNS to rapidly improve ...
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Vagus Nerve Stimulation as a Gateway to Interoception - Frontiers
Jul 28, 2020 · We review a range of cognitive, affective and clinical research using Vagus Nerve Stimulation, showing that it can be applied to the study of interoception.Introduction · Preconscious Impacts on... · Psychological Dimensions... · Discussion
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[2309.05999] Life-inspired Interoceptive Artificial Intelligence ... - arXiv
Sep 12, 2023 · This paper focuses on interoception, monitoring internal environments, to build autonomous and adaptive AI agents, inspired by living organisms.
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A machine learning approach towards the differentiation between ...
We used machine learning to classify interoceptive sensibility by contrasting using data from a randomized control trial of interoceptive training.
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How Aging Shapes Interoception: A Multimodal, Multidimensional ...
Apr 10, 2025 · Our results revealed that older age was associated with reduced cardiac interoceptive sensitivity during perturbation, while respiratory ...
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Psychedelics and the Autonomic Nervous System: A Perspective on ...
Feb 18, 2025 · Emerging research suggests that psychedelics may enhance vagal tone, as reflected in increased HRV during and after psychedelic experiences.Psychedelics and the... · Psychedelics and... · Rebalancing the ANS...<|control11|><|separator|>