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Motor system

The motor system, also known as the somatic motor system, is the integrated network of neural structures within the central and peripheral nervous systems that enables the planning, coordination, and execution of voluntary movements by activating skeletal muscles.^[1] It transforms sensory inputs, cognitive intentions, and environmental demands into precise motor outputs, ensuring adaptive behaviors such as locomotion, manipulation of objects, and communication through gestures.^[2] This system operates hierarchically to refine control from high-level goal-setting to low-level muscle activation, distinguishing it from the autonomic motor system, which governs involuntary functions like heart rate and digestion.^[3]^[1] At its core, the motor system comprises four main hierarchical levels: the spinal cord, which handles reflexive and basic locomotor patterns via motor neurons and interneurons; the brainstem, which integrates postural control and automatic adjustments; the motor cortex in the frontal lobe, responsible for initiating and sequencing voluntary actions; and the association cortex, which incorporates higher cognitive planning and decision-making.^[2] Parallel loops involving the basal ganglia and cerebellum, connected through the thalamus, provide essential feedback for motor learning, timing, and error correction, preventing unwanted movements and fine-tuning coordination.^[3] The peripheral component includes alpha motor neurons in the spinal cord's ventral horn, which serve as the "final common pathway" to directly innervate skeletal muscle fibers, along with sensory receptors like muscle spindles (detecting length and velocity) and Golgi tendon organs (monitoring force) that supply proprioceptive feedback for ongoing adjustments.^[2]^[1] Functionally, the motor system supports volitional control by processing multisensory information to generate smooth, efficient movements while maintaining balance and posture, often unconsciously adapting to changes in body mechanics or external loads.^[2] Disruptions at any level—such as upper motor neuron damage in the cortex or brainstem leading to spasticity, or lower motor neuron lesions causing flaccid paralysis—highlight its vulnerability and underscore its role in daily function and rehabilitation strategies.^[4] Through this intricate interplay, the motor system not only executes physical actions but also facilitates learning and skill acquisition, forming the foundation of human motor behavior.^[3]

Overview

Definition and Scope

The motor system comprises the central and peripheral neural structures responsible for generating and executing motor behaviors, encompassing the control of skeletal muscles, posture maintenance, and locomotion. This includes neural circuits that translate intentions into coordinated actions, from simple reflexes to complex voluntary movements.^[5] Recent neuroscience reviews emphasize the motor system's reliance on integrated sensorimotor loops, where sensory feedback continuously refines motor output to ensure precision and adaptability in dynamic environments.^[6] The scope of the motor system extends to both voluntary and involuntary components, distinguishing the pyramidal pathways for direct, fine-tuned control of skilled movements from the extrapyramidal pathways that handle automatic adjustments, balance, and coordination. This division arose in 19th-century neuroanatomy, with early classifications by Jean-Martin Charcot and contemporaries like Ludwig Türck mapping descending motor tracts and differentiating pyramidal from non-pyramidal influences on movement.^[7] At its core, the motor system features two key neural divisions: upper motor neurons (UMNs) originating in the central nervous system to initiate and modulate commands; and lower motor neurons (LMNs) situated in the spinal cord and brainstem that directly innervate muscles. These elements form a hierarchical organization, with UMNs providing supraspinal oversight and LMNs serving as the final output pathway to the effector skeletal muscles that produce force and motion.^[8]

Functions and Integration

The motor system plays a central role in initiating voluntary movements by generating neural signals that activate skeletal muscles, enabling purposeful actions such as reaching or walking.^[9] It also maintains posture and balance through continuous adjustments to gravitational and environmental forces, ensuring stability during static and dynamic activities.^[4] Furthermore, the system coordinates fine motor skills, like precise finger manipulations in writing, and gross motor skills, such as running, by integrating timing and force across muscle groups.^[10] Additionally, it modulates muscle tone to prevent excessive rigidity or flaccidity, supporting efficient force generation and relaxation.^[11] The motor system integrates closely with sensory systems, particularly proprioception from muscle spindles and joint receptors, to provide real-time feedback on body position and movement, allowing for adaptive corrections during tasks.^[10] This sensory-motor interplay is essential for skilled actions, as disruptions in proprioceptive input impair coordination.^[12] Integration with the autonomic nervous system facilitates circulatory adjustments, such as increased heart rate and blood flow to muscles during exertion, optimizing energy delivery for sustained movement.^[13] Cognitively, the motor system collaborates with prefrontal cortex regions for planning complex sequences, incorporating decision-making to align movements with goals like tool manipulation.^[14] From an evolutionary standpoint, the motor system evolved to support survival behaviors, including predation through agile pursuit and escape via rapid evasion, enhancing reproductive success in ancestral environments.^[15] In modern humans, this foundational system extends to skilled actions, such as tool use, reflecting adaptations for environmental interaction and cultural transmission.^[16] The pyramidal system primarily contributes to voluntary control, while the extrapyramidal system handles automatic aspects, illustrating a division that optimizes both deliberate and reflexive responses.^[4]

Anatomy

Central Components

The primary motor cortex (M1), located in the precentral gyrus of the frontal lobe (Brodmann area 4), serves as the main output region for voluntary movements, executing motor commands through descending pathways.^[17] It exhibits a somatotopic organization, often depicted as a motor homunculus, where body parts are represented in a distorted map proportional to their cortical control rather than physical size, with disproportionately large areas devoted to the hands, fingers, and face due to their fine motor demands.^[18]^[19] This organization allows precise, fractionated control of skilled movements, such as grasping or speaking.^[18] Adjacent to M1, the premotor cortex (PMC) and supplementary motor area (SMA) contribute to higher-order aspects of motor function, particularly planning and sequencing complex actions. The lateral PMC selects and prepares movements based on external sensory cues, such as visual or auditory stimuli, facilitating goal-directed behaviors like reaching for an object.^[20] In contrast, the medial SMA, located on the dorsal surface of the frontal lobe, is involved in internally generated movements, bimanual coordination, and the temporal organization of action sequences, activating earlier in the planning phase before movement onset.^[21]^[22] These areas integrate sensory information and prior experiences to refine motor programs, sending projections to M1 and brainstem structures.^[20] In the brainstem, nuclei such as the red nucleus and vestibular nuclei act as key integration hubs, modulating motor output by combining descending cortical signals with sensory feedback for posture and balance. The red nucleus, situated in the midbrain tegmentum, relays cerebellar influences to spinal motor circuits, aiding in limb coordination and flexor tone.^[23] The vestibular nuclei, spanning the pontomedullary junction, process balance and head position data to maintain equilibrium and stabilize gaze during movement.^[24]^[25] At the spinal level, anterior horn cells in the ventral horn house lower motor neurons that directly innervate skeletal muscles, integrating upper motor neuron inputs from the cortex and brainstem to generate precise force and timing in motor responses.^[9]^[26] These cells form the final common pathway for voluntary and reflexive actions.^[9] The cerebellum and basal ganglia serve as subcortical modulatory centers, fine-tuning motor performance without directly initiating movements. The cerebellum coordinates timing, error correction, and smooth execution by predicting sensory consequences of actions and adjusting ongoing motor commands.^[27] The basal ganglia, comprising structures like the striatum, globus pallidus, and subthalamic nucleus, regulate voluntary movement initiation and suppression through loops that gate cortical outputs, preventing unwanted actions and supporting habit formation.^[28]^[29] Together, these regions provide essential feedback to upper motor neurons in descending pathways, ensuring adaptive and efficient motor control.^[28]

Peripheral Components

The peripheral components of the motor system encompass the neural and muscular structures outside the central nervous system that transmit and execute motor commands to produce movement. These elements include lower motor neurons (LMNs), peripheral nerves, neuromuscular junctions, and skeletal muscles, which collectively convert neural signals into mechanical force. Alpha motor neurons, located in the ventral horn of the spinal cord and brainstem nuclei, innervate extrafusal muscle fibers to directly generate force for skeletal muscle contraction.^[9] These neurons form the final common pathway for motor output, receiving inputs from upper motor neurons and interneurons to drive precise and graded muscle activation.^[2] Gamma motor neurons, also situated in the ventral horn and cranial motor nuclei, innervate intrafusal muscle fibers within muscle spindles to regulate muscle tone and sensitivity to stretch.^[9] By contracting the ends of intrafusal fibers, gamma motor neurons maintain spindle sensitivity during muscle lengthening or shortening, ensuring continuous proprioceptive feedback without disrupting overall force production.^[3] Both alpha and gamma motor neurons extend axons via spinal nerves or cranial nerves, forming motor units that allow for coordinated control of muscle activity.^[30] Peripheral nerves serve as the conduits for motor signals from the spinal cord and brainstem to effector organs. For head and neck movements, cranial nerves III (oculomotor), IV (trochlear), VI (abducens), VII (facial), and XII (hypoglossal) provide motor innervation to extraocular, facial, and tongue muscles, enabling precise control of eye, facial expression, and swallowing actions.^[31] Spinal nerves, emerging from the spinal cord as 31 pairs, innervate limb and trunk muscles through mixed sensory-motor branches organized into plexuses such as the brachial and lumbosacral, facilitating locomotion and postural adjustments.^[32] At the neuromuscular junction, the axon terminal of a motor neuron synapses with the muscle fiber, where arrival of an action potential triggers calcium influx and exocytosis of synaptic vesicles containing acetylcholine (ACh).^[33] This ACh release binds to nicotinic receptors on the postsynaptic membrane, depolarizing the muscle fiber and initiating contraction via propagation of the end-plate potential.^[33] Skeletal muscles, the primary effectors of the motor system, consist of multinucleated fibers organized into motor units, where one alpha motor neuron innervates a group of fibers to produce graded force through recruitment and rate coding.^[34] Muscle fibers are classified into slow-twitch (Type I) and fast-twitch (Type II) types based on contractile speed, fatigue resistance, and metabolic properties; slow-twitch fibers rely on oxidative metabolism for sustained, low-force contractions, as seen in postural muscles like the soleus.^[34] Fast-twitch fibers, subdivided into oxidative-glycolytic (Type IIA) and glycolytic (Type IIB/X), generate rapid, high-force outputs for activities like sprinting but fatigue more quickly due to anaerobic energy reliance.^[35] Motor unit organization allows fine control: small, slow-twitch units activate first for precise movements, while larger, fast-twitch units recruit for greater power, enabling a wide range of force gradation.^[34] Autonomic influences modulate motor endurance by regulating blood flow and energy supply to skeletal muscles during prolonged activity. Sympathetic activation induces vasoconstriction in skeletal muscle vessels primarily via alpha-adrenergic receptors, but during exercise, functional sympatholysis—where local metabolic factors attenuate this vasoconstrictor tone—promotes vasodilation to enhance oxygen delivery and delay fatigue.^[36] This functional sympatholysis, where local metabolic factors attenuate sympathetic vasoconstrictor tone, ensures sustained perfusion, as evidenced during dynamic exercise where muscle blood flow increases up to 20-fold.^[37] Such autonomic adjustments are critical for maintaining motor performance in endurance tasks, integrating with somatic motor control without altering primary force generation.^[36]

Pyramidal System

Corticospinal Tract

The corticospinal tract serves as the principal descending pathway for voluntary motor control, particularly facilitating skilled and fractionated movements of the limbs and trunk.^[38] Originating primarily from the upper motor neurons in layer V of the primary motor cortex, it conveys signals that enable precise, independent control of distal musculature, distinguishing it from coarser motor pathways.^[39] The foundational understanding of this tract's cortical origins traces back to 1870, when Gustav Fritsch and Eduard Hitzig demonstrated through electrical stimulation of the dog cerebral cortex that specific regions elicit contralateral body movements, establishing the motor cortex's excitability and topographic organization.^[40] This discovery laid the groundwork for recognizing the pyramidal cells' role in descending motor commands, later linked directly to the corticospinal pathway.^[40] The tract's fibers arise from large pyramidal neurons, including the prominent Betz cells in the primary motor cortex (Brodmann area 4), with additional contributions from premotor and somatosensory areas.^[39] These axons bundle into the corona radiata, then descend through the posterior limb of the internal capsule, the cerebral peduncles of the midbrain, the basilar pons, and finally converge into the medullary pyramids, forming the visible ventral bulges on the brainstem's anterior surface.^[41] At the caudal medulla, the pyramidal decussation occurs, where approximately 90% of the fibers cross the midline to form the lateral corticospinal tract in the contralateral spinal cord's lateral funiculus, while the remaining 10% descend ipsilaterally as the anterior corticospinal tract in the ventral funiculus.^[42] The lateral tract predominates in influencing limb movements, whereas the anterior tract primarily modulates axial and proximal musculature.^[43] Throughout its descent, the tract exhibits somatotopic organization, with fibers destined for cervical spinal levels (controlling upper limbs) comprising about 55% of the total, followed by 25% for lumbosacral levels (lower limbs) and 20% for thoracic segments.^[44] This medial-to-lateral and rostral-to-caudal arrangement—with cervical fibers positioned more medially than lumbosacral fibers—supports the tract's capacity for independent control of individual digits and fine motor skills in the distal extremities.^[45] Upon reaching the spinal cord, the fibers from both tracts synapse primarily with interneurons in the dorsal and intermediate gray matter, which in turn connect to lower motor neurons in the anterior horn; however, direct monosynaptic projections to lower motor neurons also occur, particularly to those innervating distal limb muscles for precise control.^[46] This indirect and direct termination allows for integration and refinement of motor commands, essential for coordinated voluntary actions.^[46] The corticospinal tract's direct cortical-spinal linkage underpins fractionated movements, such as finger opposition, enabling humans' advanced manual dexterity compared to other primates. Its activity is further modulated by extrapyramidal inputs from the basal ganglia and cerebellum, which adjust tone and posture without overriding voluntary intent.^[47]

Corticobulbar Tract

The corticobulbar tract constitutes a major descending motor pathway within the pyramidal system, originating from upper motor neurons in the cerebral cortex to provide voluntary control over cranial nerve-innervated muscles of the head and neck.^[48] Unlike the corticospinal tract, which extends to the spinal cord for limb and trunk movements, the corticobulbar tract terminates in the brainstem, synapsing with lower motor neurons in the motor nuclei of cranial nerves.^[48] This pathway enables precise, cortically driven actions essential for functions such as facial expression, mastication, swallowing, and articulation in speech.^[48] Fibers of the corticobulbar tract primarily arise from pyramidal cells in the primary motor cortex (Brodmann area 4) within the precentral gyrus, with additional contributions from premotor (area 6) and supplementary motor regions.^[48] These axons descend through the corona radiata, converge into a compact bundle in the genu of the internal capsule—occupying the middle third of the cerebral peduncles—and continue through the basis pontis and medullary pyramids before dispersing into the pontine and medullary tegmentum.^[48] From there, they project to specific brainstem nuclei, either directly or via short interneurons, without a prominent decussation like that seen in the corticospinal tract.^[48] The tract innervates the motor nuclei of several cranial nerves, including the trigeminal (CN V) for jaw muscles involved in mastication, the facial (CN VII) for mimetic facial muscles, the ambiguus nucleus of the glossopharyngeal (CN IX) and vagus (CN X) for pharyngeal and laryngeal muscles in swallowing and phonation, the accessory (CN XI) for sternocleidomastoid and trapezius, and the hypoglossal (CN XII) for tongue protrusion and manipulation.^[48] A distinctive feature is its pattern of bilateral cortical innervation to most of these nuclei, allowing input from both cerebral hemispheres and providing functional redundancy; for instance, the upper division of the facial nucleus receives bilateral projections, enabling both sides of the cortex to control forehead and eye closure muscles.^[48] In contrast, the lower facial nucleus and portions of the hypoglossal nucleus receive predominantly contralateral input, resulting in lateralized control for lower lip and mouth movements as well as certain tongue actions.^[48] This mixed innervation scheme—bilateral for upper cranial structures and more unilateral for lower ones—underlies the characteristic patterns of impairment in bilateral upper motor neuron lesions, such as pseudobulbar palsy, where preserved bilateral pathways spare certain functions while others are disproportionately affected.^[48] Through its connections, the corticobulbar tract facilitates the voluntary modulation of speech and facial gestures, coordinating the rapid, fine adjustments needed for articulation, emotional expression, and nonverbal communication.^[48] The relatively shorter trajectory to brainstem targets, compared to the longer descent of the corticospinal tract, supports efficient signaling for these proximal motor demands.^[49] Overall, this tract exemplifies the pyramidal system's role in direct cortico-nuclear control, distinct from the extrapyramidal influences on modulation and posture.^[48]

Extrapyramidal System

Basal Ganglia Circuits

The basal ganglia form a group of interconnected subcortical nuclei that play a crucial role in modulating motor initiation and suppression through parallel circuits. Key structures include the striatum, comprising the caudate nucleus and putamen, which receives major cortical inputs; the globus pallidus, divided into the external (GPe) and internal (GPi) segments; the subthalamic nucleus (STN); and the substantia nigra, consisting of the pars compacta (SNc) for dopaminergic projections and the pars reticulata (SNr) as an output nucleus.^[50] These components integrate excitatory glutamatergic inputs from the cortex and thalamus, processing them via inhibitory GABAergic and excitatory glutamatergic connections to influence thalamocortical motor loops.^[51] The direct pathway facilitates movement selection by disinhibiting thalamic projections to the motor cortex. This circuit begins with glutamatergic projections from the cortex exciting medium spiny neurons (MSNs) in the striatum that express D1 dopamine receptors, which in turn provide GABAergic inhibition to the GPi and SNr. The resulting suppression of tonic inhibitory output from GPi/SNr allows the thalamus to excite the cortex, promoting voluntary motor actions.^[50] This pathway operates in parallel with cortical inputs to selectively enhance desired movements while maintaining balance with suppressive mechanisms.^[51] In contrast, the indirect pathway inhibits unwanted movements by enhancing basal ganglia output to the thalamus. Cortical glutamatergic inputs excite striatal MSNs expressing D2 dopamine receptors, which inhibit the GPe via GABA. This disinhibits the STN, leading to glutamatergic excitation of the GPi/SNr, thereby increasing their inhibitory GABAergic projections to the thalamus and suppressing cortical motor activity.^[50] The interplay between direct and indirect pathways enables fine-tuned action selection, with the indirect route preventing interference from competing motor programs.^[51] Dopamine released from the SNc modulates these pathways differentially: it excites the direct pathway through D1 receptor activation on striatal MSNs, enhancing their excitability and synaptic strengthening, while inhibiting the indirect pathway via D2 receptors, reducing MSN activity and promoting synaptic weakening.^[52] This balanced modulation supports smooth motor control; however, dopamine depletion in the SNc, as seen in Parkinson's disease, disrupts the equilibrium by underactivating the direct pathway and overactivating the indirect pathway, leading to excessive thalamic inhibition and hypokinetic symptoms.^[51]

Cerebellar Pathways

The cerebellar pathways form a critical component of the extrapyramidal motor system, facilitating coordination, timing, and adaptation of movements through bidirectional connections with sensory and motor regions. These pathways process afferent signals to generate precise efferent outputs, enabling the cerebellum to refine motor commands without directly innervating spinal motoneurons. The cerebellum's influence on motor control arises from its integration of sensory feedback and predictive modeling, distinct from the action selection roles of other structures. The cerebellum is functionally divided into three main regions, each contributing uniquely to motor functions. The vestibulocerebellum, comprising the flocculonodular lobe, primarily regulates balance, posture, and eye movements by integrating vestibular inputs for equilibrium maintenance.^[53] The spinocerebellum, located in the vermis and intermediate zones, focuses on limb and trunk coordination, adjusting proximal and distal muscle synergies based on proprioceptive feedback from the body.^[53] The cerebrocerebellum, encompassing the lateral hemispheres, supports motor planning and execution of skilled, voluntary movements, such as those involved in fine manipulation or speech articulation.^[53] These divisions ensure specialized processing while allowing holistic motor integration.^[27] Afferent inputs to the cerebellum arrive primarily via two pathways: mossy fibers and climbing fibers. Mossy fibers originate from diverse sources, including the spinal cord, brainstem nuclei, and pontine projections from the cerebral cortex, synapsing onto granule cells in the cerebellar cortex to convey broad sensory and motor context for ongoing movements.^[54] Climbing fibers, arising exclusively from the inferior olivary nucleus in the brainstem, provide high-fidelity error signals by strongly activating individual Purkinje cells, highlighting discrepancies between intended and actual motor outcomes.^[54] This dual input system allows the cerebellum to monitor and correct movement errors in real time.^[27] Within the cerebellar cortex, granule cells excite Purkinje cells via parallel fibers, while Purkinje cells—the principal output neurons—inhibit deep cerebellar nuclei through GABAergic projections. The deep nuclei (dentate, interpositus, and fastigial) integrate cortical inhibition with direct excitatory inputs from mossy and climbing fibers, generating the cerebellum's final efferent signals. These nuclei relay outputs primarily via the superior cerebellar peduncle to the contralateral ventrolateral thalamus and red nucleus, which in turn project to the motor and premotor cortices, modulating descending motor commands.^[54] Specifically, the dentate nucleus influences skilled limb movements by targeting motor cortical areas, while the interpositus nucleus contributes to proximal limb coordination and eyeblink responses through thalamic and rubral pathways.^[55] Cerebellar pathways operate through feedforward and feedback loops to predict and refine movement trajectories. In feedforward control, internal models in the cerebrocerebellum anticipate sensory consequences of actions, allowing proactive adjustments for smooth execution, such as grip force modulation during object handling.^[27] Feedback mechanisms, driven by climbing fiber error signals, enable corrective adaptations via synaptic plasticity, particularly long-term depression (LTD) at parallel fiber-Purkinje cell synapses, where coincident activation weakens erroneous connections to refine future movements.^[56] This LTD process, involving calcium influx and AMPA receptor internalization, underpins motor learning and error minimization.^[56] By relaying precise signals from the dentate and interpositus nuclei to the motor cortex, cerebellar pathways prevent ataxia, ensuring coordinated, tremor-free movements and compensating for perturbations like muscle fatigue or external forces.^[27] These pathways integrate with basal ganglia circuits to promote smooth motor execution, though their primary role emphasizes timing and error correction over action selection.^[27]

Motor Control

Reflex Mechanisms

Reflex mechanisms in the motor system encompass innate, rapid responses mediated by spinal cord circuits that enable automatic adjustments to sensory stimuli, serving as foundational elements for posture and basic movement without requiring higher brain involvement. These reflexes operate through well-defined neural pathways, ensuring quick protective or stabilizing actions. They are primarily spinal in origin, involving sensory afferents, interneurons, and motor neurons, and form the basis for more complex motor behaviors. The monosynaptic stretch reflex, also known as the myotatic or deep tendon reflex, is the simplest spinal reflex arc, consisting of a direct connection between sensory and motor neurons without intervening interneurons. It is initiated by muscle spindles, which detect changes in muscle length and velocity; when a muscle is stretched, Ia afferent fibers from the spindle transmit signals monosynaptically to alpha motor neurons in the spinal cord, eliciting contraction of the same muscle to resist the stretch. A classic example is the knee-jerk reflex, elicited by tapping the patellar tendon, which activates the quadriceps via spinal segments L3 and L4, producing a brief leg extension. This reflex helps maintain muscle tone and posture by compensating for unexpected perturbations. In contrast, polysynaptic reflexes involve one or more interneurons, allowing for more coordinated responses across multiple muscles. The withdrawal reflex, or flexor reflex, is a protective polysynaptic pathway triggered by nociceptors detecting painful stimuli on the skin or mucosa; sensory afferents synapse onto interneurons in the spinal cord, which then activate flexor motor neurons to withdraw the limb from harm while simultaneously inhibiting antagonist extensor muscles via reciprocal inhibition. This results in a rapid flexion of the affected limb, typically with a latency of around 100-150 milliseconds, to minimize injury.^[57] The pathway is multisegmental, enabling widespread muscle coordination for effective escape. The crossed extensor reflex complements the withdrawal reflex by providing postural stability during unilateral limb flexion, particularly in weight-bearing contexts like locomotion. When one limb withdraws, interneurons in the spinal cord transmit signals contralaterally via commissural pathways, exciting extensor motor neurons in the opposite limb to support body weight and prevent falling. This bilateral coordination ensures balance, as the extension counters the flexion on the stimulated side. Descending inputs from the pyramidal system can modulate the gain of these spinal reflexes to adapt them to ongoing motor demands. Central pattern generators (CPGs) represent specialized spinal circuits capable of producing rhythmic motor patterns independently of sensory or descending inputs, underlying innate behaviors such as locomotion. These neuronal networks, located in the lumbar spinal cord for hindlimb movements, consist of interconnected excitatory and inhibitory interneurons that generate alternating flexor-extensor bursts, as demonstrated in decerebrate animal models. In mammals, CPGs coordinate stepping during walking by timing muscle activations across limbs, with sensory feedback fine-tuning the rhythm but not essential for its initiation. Seminal studies in cats have shown that spinalized preparations can sustain locomotion-like activity when pharmacologically activated, highlighting the CPG's role in rhythmic motor control.

Hierarchical Organization

The motor system exhibits a hierarchical organization that coordinates complex movements through layered neural control, integrating planning, modulation, and execution across multiple levels of the central nervous system. At the highest level, the cerebral cortex, particularly the primary motor cortex and premotor areas, is responsible for planning and initiating voluntary movements, generating commands based on sensory inputs and cognitive goals to select appropriate motor actions.^[58] Subcortical structures, including the basal ganglia and cerebellum, provide essential modulation: the basal ganglia facilitate action selection and suppression of unwanted movements to support goal-directed behaviors, while the cerebellum refines timing, coordination, and error correction through predictive adjustments.^[58] The brainstem serves as an intermediate layer for maintaining posture and balance, integrating subcortical signals with sensory feedback to stabilize the body during locomotion and orienting responses.^[58] Finally, spinal cord circuits handle direct execution, where lower motor neurons (LMNs) innervate skeletal muscles to produce force and movement patterns.^[58] Descending pathways from upper motor neurons (UMNs) in higher centers exert facilitatory and inhibitory influences on LMNs via a network of interneurons, enabling precise control over motor output. Excitatory UMNs, primarily using glutamate as the neurotransmitter, directly or indirectly activate LMNs to promote muscle contraction, while inhibitory interneurons release gamma-aminobutyric acid (GABA) to suppress extraneous activity and prevent overactivation. This balance allows for smooth transitions between muscle groups, as seen in the pyramidal tracts that convey cortical commands to spinal levels.^[58] Sensory-motor loops further refine this hierarchy by incorporating real-time proprioceptive feedback, which informs ongoing adjustments to ensure accuracy and adaptability. Proprioceptive afferents from muscle spindles and Golgi tendon organs travel via the dorsal columns to reach higher centers, enabling the cortex and cerebellum to correct deviations in limb position and force during movement.^[59] For instance, this feedback stabilizes locomotion by modulating spinal reflexes in response to terrain changes, integrating seamlessly with descending commands.^[60] Central to this organization is the concept of motor programs, which are pre-wired neural sequences stored primarily in subcortical and spinal circuits that can be flexibly adapted by higher centers for efficient execution of repetitive or stereotyped actions. These programs, such as central pattern generators in the spinal cord for rhythmic movements like walking, allow for rapid, automatic behaviors while permitting cortical overrides for novel contexts.^[61] Basal ganglia circuits play a key role in selecting and initiating these programs, ensuring their alignment with behavioral goals.^[62]

Development and Plasticity

Embryonic Formation

The motor system originates during early embryonic development from the neural tube, which forms through primary neurulation between the third and fourth weeks of gestation.^[63] As the neural plate folds and closes, the tube differentiates into dorsal and ventral regions separated by the sulcus limitans. The ventral basal plate generates motor neurons responsible for efferent pathways, while the dorsal alar plate produces sensory neurons for afferent functions.^[64] This dorsoventral patterning establishes the foundational organization of the central nervous system's motor and sensory components by the end of the fourth gestational week.^[65] Motor neurons in the cerebral cortex arise from progenitor cells in the ventricular zone and undergo radial migration to their final positions in the cortical plate, a process that begins around the eighth week of gestation and continues through the second trimester.^[66] Corticospinal tract axons, originating from layer V pyramidal neurons in the motor cortex, initiate growth toward the spinal cord by the third month of gestation, with the tract becoming identifiable in the brainstem and internal capsule around 13 weeks.^[67] These axons progressively elongate caudally, reaching the pyramidal decussation in the medulla by approximately the fifth month, where a majority cross the midline to form the lateral corticospinal tract.^[68] The segmental organization of the motor system is influenced by interactions between the developing neural tube and adjacent somites, blocks of paraxial mesoderm that form along the embryonic axis starting in the third week. Somites provide inductive signals that guide the outgrowth and patterning of spinal nerves, ensuring proper alignment of motor axons with target muscles in the periphery.^[69] Hox genes, a family of homeobox transcription factors expressed in collinear patterns along the rostrocaudal axis, play a critical role in specifying motor neuron identities and their innervation targets, particularly for limb-innervating pools in the brachial and lumbar enlargements.^[70] For instance, combinations of Hox proteins such as Hox6 and Hox10 define columnar subtypes of motor neurons that project to specific muscle groups, establishing topographic connectivity during the fourth to eighth weeks of gestation.^[71] Synapse formation in the motor system, including neuromuscular junctions and central connections, begins prenatally, with neuromuscular junctions establishing around 7-8 weeks gestation and maturing perinatally, while central synaptic connections in the cortex continue developing postnatally, reaching peak density around 2-3 years of age as axons contact target cells.^[72] This phase represents a critical window of vulnerability, where exposure to teratogens such as alcohol can disrupt neuronal migration, axon guidance, and synaptic maturation, leading to long-term motor deficits as seen in fetal alcohol spectrum disorders.^[73] These developmental processes lay the groundwork for motor circuitry, with postnatal plasticity allowing further refinements in connectivity.^[66]

Adaptive Changes

The motor system exhibits remarkable adaptive changes through experience-dependent plasticity, enabling modifications in neural circuits to support skill acquisition, recovery from injury, and compensation for age-related declines. These adaptations primarily occur postnatally, contrasting with the fixed developmental wiring established during embryogenesis, and involve both structural and functional reorganizations that enhance motor performance over time. Recent studies as of 2024 have challenged assumptions about motor learning rates across ages, showing young adults may learn certain skills faster than children, while 2025 advancements in portable technologies enable earlier detection of motor delays.^[74]^[75]^[76] Synaptic plasticity in the motor cortex plays a central role in skill learning, with long-term potentiation (LTP) facilitating strengthened connections between neurons involved in coordinated movements. LTP, induced by repetitive activation of motor pathways, underlies the consolidation of learned motor behaviors, such as reaching or grasping, by enhancing synaptic efficacy in primary motor areas.^[77] This process aligns with Hebbian principles, where co-active neurons—“cells that fire together wire together”—form enduring associations that support procedural memory and fine-tune motor output during practice.^[78] Following injury, such as stroke, the motor system undergoes cortical remapping, where undamaged adjacent cortical regions assume functions of the affected areas through mechanisms like axonal sprouting and synaptic reorganization. In peri-infarct zones, surviving neurons extend new projections to reinnervate denervated targets, promoting recovery of voluntary movement as observed in longitudinal imaging studies of stroke patients.^[79] This remapping is activity-dependent and can be enhanced by targeted interventions, illustrating the system's capacity for repair.^[80] Mirror neurons, identified in premotor and parietal cortices, contribute to observational motor learning by activating both during action execution and perception of similar actions in others, thereby facilitating imitation and skill transfer without direct practice. This vicarious activation supports social learning contexts, such as acquiring tool use through demonstration.^[81] Neurorehabilitation techniques like constraint-induced movement therapy (CIMT) leverage these adaptive mechanisms by restricting unaffected limb use, forcing intensive practice of the impaired side to drive cortical reorganization and improve upper extremity function in chronic stroke survivors.^[82] Age-related changes in motor plasticity include a progressive decline after age 60, characterized by reduced LTP induction and slower remapping, which contributes to diminished motor learning efficiency and increased vulnerability to functional loss. However, regular aerobic and resistance exercise can mitigate this decline by preserving synaptic integrity and enhancing cortical excitability, thereby maintaining adaptive capacity into later life.^[83] Complementary processes, such as long-term depression in cerebellar circuits, support error-based refinements that integrate with cortical adaptations for overall motor improvement.^[84]

Clinical Aspects

Associated Disorders

Disorders of the motor system encompass a range of pathologies affecting upper motor neurons (UMNs), lower motor neurons (LMNs), extrapyramidal structures, and cerebellar pathways, each manifesting distinct clinical features tied to the disrupted neural components.^[4] Upper motor neuron disorders, such as those resulting from stroke, involve lesions in the corticospinal tract, leading to spastic paralysis characterized by increased muscle tone, hyperreflexia, and weakness, typically contralateral to the lesion site due to interruption of descending inhibitory and facilitatory signals from the motor cortex.^[85] In stroke, particularly ischemic events in the middle cerebral artery territory, this results in hemiparesis with spasticity emerging subacutely as upper motor neuron pathways are compromised, impairing voluntary movement control.^[4] Amyotrophic lateral sclerosis (ALS) represents a progressive upper and lower motor neuron degeneration, where UMNs in the cortex and LMNs in the spinal cord anterior horn degenerate, causing a mixed picture of spasticity, fasciculations, and muscle atrophy that spreads from focal onset to generalized weakness.^[86] Lower motor neuron disorders directly impair the final common pathway to skeletal muscles, resulting in flaccid weakness, hypotonia, hyporeflexia, and atrophy without the spasticity seen in UMN lesions.^[87] Peripheral neuropathy, often due to axonal damage in motor nerves from causes like diabetes or toxins, presents with distal flaccid weakness and sensory loss, reflecting denervation of muscle fibers and disrupted neuromuscular transmission.^[88] Poliomyelitis exemplifies acute LMN destruction, where poliovirus selectively targets anterior horn cells in the spinal cord, causing irreversible flaccid paralysis and muscle wasting in affected limbs due to the loss of alpha motor neurons.^[89] Extrapyramidal disorders arise from dysfunction in basal ganglia circuits, disrupting smooth modulation of movement initiation and execution. Parkinson's disease involves progressive loss of dopaminergic neurons in the substantia nigra pars compacta, depleting dopamine in the striatum and leading to bradykinesia, resting tremor, rigidity, and postural instability as the direct and indirect pathways become imbalanced.^[90] Huntington's disease, a genetic disorder caused by CAG repeat expansions in the HTT gene, results in striatal atrophy, particularly of medium spiny neurons in the caudate and putamen, manifesting as chorea—involuntary, irregular movements—along with progressive motor decline due to disrupted extrapyramidal output to the thalamus.^[91] Cerebellar disorders impair coordination and fine motor control through degeneration of Purkinje cells or afferent/efferent pathways, leading to ataxia and intention tremor. Spinocerebellar ataxias (SCAs), a group of autosomal dominant disorders, cause progressive cerebellar degeneration with intention tremor that worsens during goal-directed movements, dysmetria, and gait instability due to faulty error correction in motor planning.^[92] These manifestations highlight the cerebellum's role in predictive control, where lesions disrupt the dentato-thalamo-cortical loop essential for precise timing and amplitude of movements.^[93]

Assessment and Treatment

Assessment of motor system impairments begins with clinical examinations that evaluate muscle tone, strength, reflexes, and coordination to differentiate upper motor neuron (UMN) from lower motor neuron (LMN) lesions. For instance, the Babinski sign, elicited by stroking the sole of the foot, results in dorsiflexion of the big toe and fanning of the other toes in UMN lesions, indicating corticospinal tract disruption, whereas a normal flexor response occurs in healthy adults.^[94] These exams are foundational, often supplemented by neuroimaging and electrophysiological tests for confirmation.^[95] Neuroimaging techniques, such as magnetic resonance imaging (MRI) with diffusion tensor imaging (DTI), assess the integrity of motor tracts like the corticospinal tract by measuring white matter fractional anisotropy, which decreases in degenerative conditions.^[96]^[97] For Parkinson's disease, dopamine transporter (DaT) scans using iodine-123 ioflupane SPECT imaging detect reduced striatal dopamine uptake, aiding differentiation from essential tremor with high sensitivity (up to 95%) and specificity (up to 100%).^[98]^[99] Electrophysiological studies, including electromyography (EMG) and nerve conduction studies (NCS), are essential for LMN disorders, revealing denervation potentials like fibrillation and fasciculations on EMG, alongside reduced compound muscle action potentials on NCS in conditions such as amyotrophic lateral sclerosis (ALS).^[100]^[101] These tests quantify nerve and muscle dysfunction, guiding localization of lesions within the motor system. Pharmacological treatments target specific impairments; levodopa, combined with carbidopa, replenishes dopamine in Parkinson's disease, improving motor symptoms like bradykinesia by 50-70% in early stages, though long-term use may lead to dyskinesias.^[102] Botulinum toxin type A injections reduce spasticity in UMN disorders by inhibiting acetylcholine release at neuromuscular junctions, decreasing muscle tone for 3-6 months and enhancing function in 70-80% of patients.^[103]^[104] Surgical interventions, such as deep brain stimulation (DBS) of the subthalamic nucleus or globus pallidus interna in basal ganglia disorders like Parkinson's, modulates aberrant neural circuits, reducing levodopa-resistant symptoms by 40-60% and improving quality of life.^[105]^[106] DBS involves implanting electrodes connected to a pulse generator, with adjustable parameters to optimize outcomes. Rehabilitative approaches, including physical therapy, promote motor recovery through task-specific exercises that leverage neuroplasticity, such as constraint-induced movement therapy, which enhances cortical reorganization and improves upper limb function post-stroke.^[107] These interventions, when intensive, can increase motor unit recruitment and synaptic strength, supporting long-term gains. Emerging therapies include stem cell transplantation for ALS, where mesenchymal stem cells aim to replace lost motor neurons and modulate inflammation; phase II trials post-2020 have shown modest slowing of disease progression in 20-30% of participants, though safety remains a concern.^[108]^[109] For spinal muscular atrophy (SMA), onasemnogene abeparvovec (Zolgensma) gene therapy delivers functional SMN1 via AAV9 vector, achieving motor milestones in over 90% of treated infants in post-2020 follow-ups, with sustained benefits up to 5 years.^[110]^[111] Prognosis in motor system disorders improves with early intervention, as heightened neuroplasticity in initial stages allows greater adaptive reorganization; for example, timely physical therapy post-injury can enhance functional recovery by 20-50% through synaptic strengthening and axonal sprouting.^[112]^[113] Factors like intervention timing and intensity are critical, with delays reducing potential gains due to diminished plasticity windows.

References

[1]
Neural Systems - Neuroscience - NCBI Bookshelf - NIH
The motor portion of the peripheral nervous system consists of two components. Motor axons that connect the brain and spinal cord to skeletal muscles make up ...
[2]
Motor Units and Muscle Receptors (Section 3, Chapter 1 ...
The motor system hierarchy consists of 4 levels (Figure 1.2): the spinal cord, the brain stem, the motor cortex, and the association cortex.
[3]
Spinal Motor Control and Proprioception
The motor system refers to the nerve cells that are used to control our body. The key roles of the motor system are to plan, control, and execute voluntary ...
[4]
Disorders of the Motor System (Section 3, Chapter 6) Neuroscience ...
Motor system disorders result from damage at any level, including lower motor neuron syndrome (damage to alpha motor neurons) and upper motor neuron syndrome ( ...
[5]
Neuroscience - NCBI Bookshelf - NIH
Whether judged in molecular, cellular, systemic, behavioral, or cognitive terms, the human nervous system is a stupendous piece of biological machinery.
[6]
Targeting Sensory and Motor Integration for Recovery of Movement ...
Jan 21, 2022 · Stimulation methods have been developed to directly recruit the sensorimotor system and modulate neural networks to restore movement after CNS injury.
[7]
The pyramidal syndrome and the pyramidal tract: a brief historical note
Oct 27, 2011 · The discovery of the pyramidal syndrome and tract is briefly reviewed with emphasis on a few key historical aspects.
[8]
Motor neurons and the generation of spinal motor neurons diversity
There are two main types of MNs, (i) upper MNs that originate from the cerebral cortex and (ii) lower MNs that are located in the brainstem and spinal cord.Abstract · Introduction · Motor Neuron Classification · Generation of Spinal Motor...
[9]
Neuroanatomy, Motor Neuron - StatPearls - NCBI Bookshelf
Jul 24, 2023 · Motor neurons (or motoneurons) comprise various tightly controlled, complex circuits throughout the body that allows for both voluntary and involuntary ...Introduction · Structure and Function · Surgical Considerations
[10]
Targeting Sensory and Motor Integration for Recovery of Movement ...
The central nervous system (CNS) integrates sensory and motor information to acquire skilled movements, known as sensory-motor integration (SMI).
[11]
Sensorimotor Function - an overview | ScienceDirect Topics
Definition of topic Sensorimotor function refers to the integration of sensory input and motor responses, which is essential for controlling movements and is ...
[12]
Sensorimotor Integration - Physiopedia
This process involves complex interactions among sensory receptors, neural pathways, and motor systems, facilitating motor control, learning and environmental ...
[13]
The Autonomic Nervous System Differentiates between Levels of ...
While attempting to bridge motor control and cognitive science, the nascent field of embodied cognition has primarily addressed intended, goal-oriented actions.
[14]
The motor system – Introduction to Biological Psychology
Motor and sensory systems work together to generate effective movement. The forebrain and initiation of movement. In the frontal lobes of the brain, specific ...12 The Motor System · Organisation Of The Motor... · The Forebrain And Initiation...
[15]
Cortical control of behavior and attention from an evolutionary ...
Oct 6, 2021 · For animals to survive, they must interact with their environment, taking in sensory information and making appropriate motor responses.
[16]
Concepts, Goals and the Control of Survival-Related Behaviors - PMC
We then consider evidence from the neuroscience of motor control that motor actions are assembled by neural populations, not triggered by simple circuits. We ...
[17]
Primary Motor Cortex - an overview | ScienceDirect Topics
The primary motor cortex (area 4) contains the motor homunculus and gives rise to the corticospinal tract, the main effector of skilled voluntary movement.
[18]
Neurosurgery, Sensory Homunculus - StatPearls - NCBI Bookshelf
The motor homunculus is a topographic representation of the body parts and its correspondents along the precentral gyrus of the frontal lobe.
[19]
The lower motor neuron homunculus - PMC - NIH
Penfield's motor homunculus displayed pictorially the shape and size of somatic regions in proportion to their cortical representation. The key concept captured ...
[20]
The Premotor Cortex - Neuroscience - NCBI Bookshelf - NIH
The premotor cortex influences motor behavior, selecting movements based on external cues (lateral) or internal cues (medial), both involved in movement ...
[21]
Supplementary Motor Area - an overview | ScienceDirect Topics
The SMA plays a pivotal role in motor planning, execution, and sequence processing. Electrophysiological recordings and neuroimaging studies demonstrate that ...Introduction to the... · Anatomical and Functional... · Role of the Supplementary...
[22]
Premotor Cortex - an overview | ScienceDirect Topics
The supplementary motor area plays a major role in planning and generating movements, motor learning, and adaptation, including learning new sensorimotor skills ...
[23]
Red nucleus structure and function: from anatomy to clinical ...
The red nucleus (RN) is a large subcortical structure located in the ventral midbrain. Although it originated as a primitive relay between the cerebellum and ...
[24]
Upper Motor Neurons That Maintain Balance and Posture - NCBI - NIH
Both the vestibular nuclei and the reticular formation provide information to the spinal cord that maintains posture in response to environmental (or self- ...
[25]
Neuroanatomy, Brainstem - StatPearls - NCBI Bookshelf
Jul 4, 2023 · The vestibular nuclei are composed of four different nuclei (superior, inferior, lateral, and medial.) These nuclei send tracts to three ...
[26]
Lower Motor Neuron - an overview | ScienceDirect Topics
Lower motor neurons (LMNs) are motor neurons with cell bodies located in the anterior horns of the spinal cord and in the motor nuclei of the brainstem, which ...
[27]
Consensus Paper: Roles of the Cerebellum in Motor Control—The ...
These concepts suggest that the cerebellum contributes to timing and sensory acquisition and is involved in the prediction of the sensory consequences of action ...
[28]
Modulation of Movement by the Basal Ganglia - Neuroscience - NCBI
Basal ganglia influence movement by regulating upper motor neurons, forming a subcortical loop that is required for normal voluntary movement initiation.
[29]
Neuroanatomy, Basal Ganglia - StatPearls - NCBI Bookshelf
The basal ganglia is a cluster of nuclei deep to the neocortex, primarily involved in motor control, and acts as a gate-keeping mechanism for movement.
[30]
Methodological advances for studying gamma motor neurons - PMC
The α motor neurons innervate the force-generating extrafusal fibers, the γ motor neurons the intrafusal fibers of the muscle spindle, and the β motor neurons ...
[31]
Neuroanatomy, Cranial Nerve - StatPearls - NCBI Bookshelf - NIH
Jan 24, 2025 · Cranial nerves III, IV, VI, XI, and XII are purely efferent, as they provide motor output to the orbit, neck, and tongue. Cranial nerves V, VII ...
[32]
Peripheral nervous system: Anatomy, divisions, functions | Kenhub
The first set of peripheral nerves are the twelve cranial nerves: olfactory (CN I), optic (CN II), oculomotor (CN III), trochlear (CN IV), trigeminal (CN V1, ...Dermatomes · Myotomes · Dorsal root ganglion
[33]
Physiology, Neuromuscular Junction - StatPearls - NCBI Bookshelf
Feb 17, 2025 · This interaction triggers the fusion of synaptic vesicles with the presynaptic membrane, releasing ACh into the synaptic cleft via exocytosis.
[34]
The Regulation of Muscle Force - Neuroscience - NCBI Bookshelf
Slow (S) motor units provide the tension required for standing. Fast fatigue-resistant (FR) units provide the additional force needed for walking (more...)
[35]
Muscle Fibre Types - Physiopedia
The three types of muscle fibres are slow oxidative (SO), fast oxidative (FO) and fast glycolytic (FG). Most skeletal muscles in a human contain(s) all three ...
[36]
Regulation of Increased Blood Flow (Hyperemia) to Muscles During ...
Thus the autonomic nervous system serves as a regulator of blood pressure and is also critical in the regulation of skeletal muscle blood flow during exercise. ...
[37]
Muscle sympathetic nerve activity during exercise
May 3, 2019 · This review provides an updated comprehensive overview on the MSNA response to exercise including large-muscle, dynamic leg exercise, eg, two-legged cycling,
[38]
Neuroanatomy, Corticospinal Cord Tract - StatPearls - NCBI Bookshelf
Aug 14, 2023 · The corticospinal tract, AKA, the pyramidal tract, is the major neuronal pathway providing voluntary motor function.
[39]
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055626/
[40]
The discovery of motor cortex and its background - PubMed
In 1870 Gustav Fritsch and Edvard Hitzig showed that electrical stimulation of the cerebral cortex of a dog produced movements.
[41]
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3635640/
[42]
Corticospinal tract | Radiology Reference Article | Radiopaedia.org
May 9, 2017 · The corticospinal tract (also known as the pyramidal tract) is a descending white matter tract primarily concerned with motor function that extends caudally.
[43]
Neuroanatomy, Lateral Corticospinal Tract - StatPearls - NCBI - NIH
The lateral corticospinal tract contains over 90% of the fibers present in the corticospinal tract and runs the length of the spinal cord.
[44]
Corticospinal Tract - Physiopedia
At the base of the pyramids, approximately 90% of the fibers in the corticospinal tract decussate, or cross over to the other side of the brainstem, in a bundle ...
[45]
Cervical Enlargement - an overview | ScienceDirect Topics
The corticospinal tract in the newborn has not yet innervated the ... In the cervical cord segments, 55% of the fibers leave the tract and synapse ...
[46]
The role of corticospinal and extrapyramidal pathways in motor ...
Thus, specific parts of extrapyramidal pathways seem to compensate for impaired gross arm and leg movements incurred through stroke-related corticospinal tract ...
[47]
Neuroanatomy, Corticobulbar Tract - StatPearls - NCBI Bookshelf
The organization of the motor cortex is in a somatotopic manner. Cortical homunculus is a map of the representation of different parts of the body in ...
[48]
Neuroanatomy, Pyramidal Tract - StatPearls - NCBI Bookshelf - NIH
The pyramidal tract originates from the cerebral cortex, and it divides into two main tracts: the corticospinal tract and the corticobulbar tract.
[49]
Basal ganglia for beginners: the basic concepts you need to know ...
Aug 3, 2023 · Together, basal ganglia and cerebellum are essential for the movement general circuit, as they modulate the activity of the premotor cortex, ...
[50]
The functional anatomy of basal ganglia disorders - PubMed - NIH
The functional anatomy of basal ganglia disorders. Trends Neurosci. 1989 Oct;12(10):366-75. doi: 10.1016/0166-2236(89)90074-x. Authors. R L Albin, A B Young, ...
[51]
Modulation of striatal projection systems by dopamine - PMC
The ability of the striatum to use the rise and fall of dopamine (DA) to control action selection was due to the segregation of D 1 and D 2 DA receptors.
[52]
Organization of the Cerebellum - Neuroscience - NCBI Bookshelf - NIH
The cerebellum can be subdivided into three main parts based on differences in the sources of input (Figure 19.1 and Table 19.1).
[53]
Cerebellum (Section 3, Chapter 5) Neuroscience Online
The cerebellum plays a major role in adapting and fine-tuning motor programs to make accurate movements through a trial-and-error process (e.g., learning to hit ...
[54]
Convergent inputs from the dentate and the interpositus nuclei to ...
The present study demonstrated that: (1) the interpositus and the dentate nuclei excite PTNs in the motor cortex; (2) single pyramidal tract neurons receive ...
[55]
Long-term depression and other synaptic plasticity in the cerebellum
Cerebellar long-term depression (LTD) is a type of synaptic plasticity and has been considered as a critical cellular mechanism for motor learning.
[56]
Hierarchical motor control in mammals and machines - Nature
Dec 2, 2019 · We review these core principles of hierarchical control, relate them to hierarchy in the nervous system, and highlight research themes that we anticipate will ...
[57]
https://pubmed.ncbi.nlm.nih.gov/3107749/
[58]
https://www.nature.com/articles/s41467-019-13239-6
[59]
Frontiers | Sensory Circuit Remodeling and Movement Recovery After Spinal Cord Injury
### Summary: Role of Proprioceptive Feedback via Dorsal Columns in Refining Movements in Motor Control
[60]
Evolution of Motor Control: From Reflexes and Motor Programs to ...
This brief review analyzes the evolution of motor control theories along two lines that emphasize active (motor programs) and reactive (reflexes) features ...
[61]
Current Principles of Motor Control, with Special Reference to ...
Jan 1, 2020 · The forebrain and in particular the basal ganglia are involved in determining which motor programs should be recruited at a given point of time ...
[62]
Neuroanatomy, Neural Tube Development and Stages - NCBI - NIH
The central area of the neural plate invaginates and becomes the neural groove. The neural folds converge and convert the neural groove into the neural tube.
[63]
Tissue Architecture of the Central Nervous System - NCBI - NIH
(A-D) The neural tube is functionally divided into dorsal (alar) and ventral (basal) regions, separated by the sulcus limitans. As cells from the adjacent ...
[64]
Neurulation - an overview | ScienceDirect Topics
Neurulation occurs in two distinct phases: primary neurulation during weeks 3 and 4 of gestation leading to development of the brain and spinal cord (Figure 160 ...
[65]
The Basics of Brain Development - PMC - PubMed Central
This chapter is intended to provide an overview of some very basic principles of brain development, drawn from contemporary developmental neurobiology.Missing: decussation | Show results with:decussation
[66]
Anatomical Characterization of Human Fetal Brain Development ...
Apr 1, 2009 · At 13 weeks, the pontine crossing tract (pct) and the corticospinal tract (cst) can already be identified. At 15 weeks, the pct increases ...
[67]
Neuroanatomy, Spinal Cord - StatPearls - NCBI Bookshelf
The basal lamina develops into the motor area, giving rise to anterior and lateral horns and all the neurons within. The alar lamina develops as a sensory area ...
[68]
Expression of Hox Genes in the Nervous System of Vertebrates - NCBI
The purpose of this review is to highlight the expression, regulation and roles of Hox genes in patterning CNS development.
[69]
Hox Genes: Choreographers in Neural Development, Architects of ...
Oct 2, 2013 · This Review highlights the functions and mechanisms of Hox gene networks and their multifaceted roles during neuronal specification and connectivity.
[70]
Hox Genes: The Instructors Working at Motor Pools
In a tour de force, Jessell and colleagues (Dasen et al., 2005) have now examined the expression patterns for all 39 members of the Hox family of homeodomain.
[71]
Towards an Understanding of Synapse Formation: Neuron - Cell Press
Oct 24, 2018 · Axons and dendrites establish initial synaptic contacts mostly during development and the early postnatal period, although synapse formation ...
[72]
Synaptic Plasticity Abnormalities in Fetal Alcohol Spectrum Disorders
Jan 29, 2023 · The significant attribute of prenatal alcohol exposure on offspring is damage to the central nervous system (CNS), causing a range of synaptic ...
[73]
Promoting axonal rewiring to improve outcome after stroke - PMC
Axonal sprouting occurs after stroke in peri-infarct cortex and in contralateral projections to spinal cord, brainstem and striatum.
[74]
Long-Term Potentiation in the Motor Cortex | Science
Long-term potentiation (LTP) is a model for learning and memory processes. Tetanic stimulation of the sensory cortex produces LTP in motor cortical neurons.
[75]
Hebbian priming of human motor learning | Nature Communications
Jun 15, 2024 · Our findings demonstrate that non-invasively induced plasticity interacts positively with experience-dependent plasticity to promote motor learning.
[76]
Rethinking Remapping: Circuit Mechanisms of Recovery after Stroke
Nov 8, 2023 · The remapping hypothesis implies that ischemia leads to irreversible damage, and recovery proceeds as spared circuits remap to take on new functionality.
[77]
A role for ephrin-A5 in axonal sprouting, recovery, and ... - PNAS
We show that ephrin-A5 is induced in reactive astrocytes in periinfarct cortex and is an inhibitor of axonal sprouting and motor recovery in stroke.
[78]
Mirror neuron system and observational learning - ScienceDirect.com
Mirror neurons have been proposed as the neurophysiological basis of the perceptual-motor transformation mechanism [4], which allows subjects to transform ...
[79]
Effects of Constraint-Induced Movement Therapy on Patients With ...
The results indicate that CI therapy is a powerful treatment for improving the rehabilitation of movement of the affected upper extremity in chronic stroke ...
[80]
Neuronal Plasticity and Age-Related Functional Decline in the Motor ...
This review will focus on recent findings on the role of plasticity in the motor cortex for motor function and age-related changes.
[81]
Understanding the Neurophysiological and Molecular Mechanisms ...
Mar 1, 2021 · Exercise is believed to reduce atrophy within the motor system and induce neuroplasticity which, in turn, helps preserve motor function during aging.Introduction · Intracortical Circuits · Effects Of Exercise Training
[82]
Neuroanatomy, Upper Motor Neuron Lesion - StatPearls - NCBI - NIH
The pyramidal tract divides further into the corticospinal tract and the corticobulbar tract. Injury or lesions to UMN's are common because of the vast areas ...Introduction · Structure and Function · Surgical Considerations · Clinical Significance
[83]
Amyotrophic Lateral Sclerosis - StatPearls - NCBI Bookshelf - NIH
Amyotrophic lateral sclerosis most commonly begins with signs of LMN degeneration affecting the upper extremity but can also present as UMN or bulbar symptoms.
[84]
Motor Neuron Disease - StatPearls - NCBI Bookshelf
Aug 7, 2023 · Patients present with typical LMN symptoms of progressive flaccid paralysis, muscle atrophy, hyporeflexia/areflexia, and fasciculations.
[85]
Differentiating lower motor neuron syndromes - PMC - NIH
Lower motor neuron (LMN) syndromes typically present with muscle wasting and weakness and may arise from pathology affecting the distal motor nerve.
[86]
Poliomyelitis - StatPearls - NCBI Bookshelf
[CDC. Polio_HCP] CNS invasion can also result in infection and destruction of alpha motor neurons in the anterior horns of the spinal cord, the cranial nerve ...
[87]
Parkinson's Disease | National Institute of Neurological Disorders ...
Mar 5, 2025 · Studies have shown that most people with PD have lost 60 to 80% or more of the dopamine-producing cells in the substantia nigra by the time ...
[88]
Huntington Disease - StatPearls - NCBI Bookshelf - NIH
Apr 6, 2025 · Adult-onset Huntington disease is typically characterized by early striatal atrophy in the caudate. Cerebellar and cortical atrophy is seen ...
[89]
Ataxia: Dominant - Neuromuscular Home Page
Dominant Spinocerebellar Ataxia (SCA): General. Incidence: ~1 to 5 per 100,000; Average age of onset: 3rd decade; Mutation types. CAG repeats.
[90]
Postural Tremor and Ataxia Progression in Spinocerebellar Ataxias
Oct 9, 2017 · The majority of SCA patients have intention tremor, while only a small subset of SCA patients have postural tremor, suggesting different brain ...
[91]
Babinski Reflex - StatPearls - NCBI Bookshelf
Jan 1, 2023 · The Babinski reflex is done as part of the routine neurological exam and is utilized to determine the integrity of the CST.
[92]
Neurological examination - Knowledge @ AMBOSS
Sep 29, 2025 · Neurological examination is the assessment of mental status, cranial nerves, motor and sensory function, coordination, and gait for the diagnosis of ...
[93]
Diffusion Tensor Imaging - StatPearls - NCBI Bookshelf
Nov 12, 2023 · Diffusion tensor imaging is an advanced magnetic resonance imaging modality that uses the Brownian motion of water molecules to provide data for images.
[94]
Diffusion tensor imaging for the assessment of upper motor neuron ...
High angular resolution diffusion tensor imaging may be more sensitive than conventional MRI or neurologic assessment to the upper motor neuron (UMN) pathology ...
[95]
Clinical utility of DaTscan in patients with suspected Parkinsonian ...
May 24, 2021 · Our systematic review and meta-analysis show that imaging with DaTscan was associated with a change in management in approximately half the patients tested.
[96]
Using DaTscan to Diagnose Parkinson Disease - AAFP
Jun 1, 2021 · DaTscan has been approved by the US Food and Drug Administration and is most useful in differentiating between Parkinson disease and atypical essential tremor.
[97]
Electrodiagnostic Evaluation of Motor Neuron Disease - NCBI - NIH
Nov 5, 2022 · NCS and needle EMG are extensions of the neurological exam and should be performed with any suspicion of motor neuron disease.Continuing Education Activity · Introduction · Indications · Technique or Treatment
[98]
Nerve Conduction Studies and Electromyography - StatPearls - NCBI
Feb 10, 2025 · EMG is the most valuable tool for evaluating generalized lower motor neuron degeneration, such as in amyotrophic lateral sclerosis or motor ...
[99]
Parkinson Disease Treatment & Management - Medscape Reference
Sep 10, 2025 · The STN is one of the preferred surgical targets for deep brain stimulation to treat symptoms of advanced Parkinson disease. Parkinson ...
[100]
Improving Spasticity by Using Botulin Toxin - PubMed Central - NIH
Jun 24, 2024 · The various formulations and indications of botulinum toxin. Trade Name, Proprietary Name, Serotype, Approved Indication, Unit/Vial. Botox ...
[101]
Treatment of spasticity with botulinum toxin - PubMed
Botulinum toxin therapy reduces spasticity and pain associated with several disorders. Local treatment with botulinum toxins can be used as adjunctive therapy.
[102]
Deep Brain Stimulation for Parkinson's Disease—A Narrative Review
Oct 5, 2025 · DBS modulates abnormal basal ganglia circuitry by disrupting pathological neuronal firing patterns and promoting more physiological network ...
[103]
Deep Brain Stimulation for Movement Disorders of Basal Ganglia ...
Deep brain stimulation (DBS) is highly effective for both hypo- and hyperkinetic movement disorders of basal ganglia origin.
[104]
Neuroplasticity in the context of motor rehabilitation after stroke - PMC
This Review aims to provide a focused overview of neuroplasticity associated with poststroke motor impairment, and the latest experimental interventions being ...
[105]
Potential of Cellular Therapy for ALS: Current Strategies and Future ...
In this review, we summarize the current progress in cellular therapy for ALS. The underlying mechanism, current clinical trials, and the pros and cons of ...<|separator|>
[106]
Stem Cell Therapy for the Treatment of Amyotrophic Lateral Sclerosis
This review evaluates the efficacy of three stem cell types in ALS treatment: mesenchymal stem cells (MSCs), neural stem cells (NSCs), and induced pluripotent ...Missing: SMA | Show results with:SMA
[107]
Spinal muscular atrophy: From approved therapies to future ...
Recent therapeutic advances have given hope to families and patients by compensating for the deficiency in survival motor neuron (SMN) protein via gene therapy ...Missing: emerging | Show results with:emerging
[108]
Current Advances and Challenges in Gene Therapies for ...
Jan 13, 2025 · This article provides a comprehensive overview of gene-targeted therapies currently available for neurologic disorders, with a focus on their mechanisms, ...
[109]
Improving neuroplasticity and Quality of Life in children with ... - NIH
Oct 13, 2025 · There is consensus on the effectiveness of rehabilitative interventions when started early and administered intensively, leveraging neuronal ...Missing: prognosis | Show results with:prognosis
[110]
Early Diagnosis and Early Intervention in Cerebral Palsy - Frontiers
This paper reviews the opportunities and challenges for early diagnosis and early intervention in cerebral palsy (CP). CP describes a group of disorders of ...