Fact-checked by Grok 2 weeks ago

Gender binary

The gender binary is the framework classifying human gender into two distinct and complementary categories—male and feminine—corresponding to biological sex, which is defined by anisogamy, the production of either small, mobile gametes (sperm) by males or large, immobile gametes (ova) by females, a dimorphic system fundamental to sexual reproduction in humans and most gonochoric species.^[1]^[2] This binary arises from evolutionary pressures favoring specialization in gamete type, resulting in observable sexual dimorphism in traits such as reproductive organs, skeletal structure, muscle mass, and secondary characteristics like body hair distribution and vocal pitch, with males typically exhibiting greater upper-body strength and females wider pelvic geometry adapted for gestation.^[3]^[4] While developmental disorders of sex (DSDs) occur, affecting roughly 0.018% of births and involving ambiguities in genitalia, chromosomes, or gonads, these represent rare anomalies or mosaics within the binary paradigm rather than evidence of a spectrum or third sex, as no human produces both functional gamete types or an intermediate third.^[5]^[6] The gender binary has structured nearly all human societies historically, informing kinship, labor division, and mating norms, though it faces contemporary challenges from claims of gender fluidity, sparking disputes over sex-based protections in athletics, prisons, and youth healthcare, where empirical data on outcomes like post-treatment regret or desistance rates underscore tensions between biological realities and self-identification.^[7]

Biological Foundations

Definition and Core Principles

The gender binary refers to the classification of organisms, including humans, into two distinct sexes—male and female—based on their reproductive roles, specifically the type of gametes they produce or are organized to produce. Males are defined by the production of small, mobile gametes (sperm), while females produce large, immobile gametes (ova or eggs); no third gamete type exists in sexually reproducing species, rendering sex a binary trait at the level of gametic dimorphism.^[2]^[8] This definition stems from the evolutionary origin of anisogamy, where gamete size disparity evolved to optimize fertilization and parental investment, establishing a clear dichotomy without intermediates.^[1] Core principles of the gender binary in biological contexts emphasize causal realism in reproduction: sex determination serves reproductive fitness, with developmental pathways converging on one of two outcomes despite variations in secondary traits like hormones or anatomy. For instance, in humans, over 99.98% of individuals are unambiguously male or female based on gamete-producing capacity, with rare disorders of sex development (DSDs, often termed intersex conditions) representing developmental anomalies within the binary rather than evidence of a spectrum or additional categories.^[2] These principles reject conflations of sex with gender roles or identities, grounding the binary in observable, empirical markers such as gonadal function and chromosomal patterns (XY for males, XX for females in typical cases), which align with gametic criteria across mammals.^[9] Claims of a non-binary sex spectrum often arise from misapplying population-level variations in non-reproductive traits to the definitional binary, but peer-reviewed biological analyses affirm the gamete-based distinction as the immutable foundation.^[2]^[8] This binary structure is not arbitrary but causally tied to evolutionary pressures: the absence of viable third gamete types prevents the emergence of additional sexes, as fusion requires complementary anisogamous pairs for genetic recombination and offspring viability.^[1] In human physiology, this manifests in dimorphic traits—e.g., testes versus ovaries forming by 7-8 weeks of gestation—ensuring species propagation through specialized reproductive contributions, with males providing motility and females nourishment.^[8] While social or psychological constructs of gender may vary, the biological gender binary's principles prioritize these reproductive imperatives, supported by genetic and anatomical evidence that deviations (e.g., in DSDs affecting ~0.018% for ambiguous genitalia) do not negate the underlying dimorphism but highlight its robustness.^[2]

Gamete Dimorphism as Binary Criterion

In anisogamous species, including humans, biological sex is defined by the type of gamete an organism produces or is organized to produce: males generate small, mobile gametes known as spermatozoa, while females generate large, sessile gametes known as ova.^[2]^[10] This dimorphism arises from anisogamy, the evolutionary divergence of gamete sizes, where smaller gametes optimize for quantity and motility to increase fertilization chances, and larger gametes invest in nutrient reserves for zygote viability.^[11] No third gamete type—intermediate in size or function—exists in any known sexually reproducing species, rendering sex a binary category at this foundational reproductive level.^[2]^[12] Gamete size differences are stark and conserved across eukaryotes: human spermatozoa measure approximately 50–60 micrometers in length, prioritizing motility over provisions, whereas ova range from 100–150 micrometers in diameter, containing substantial yolk and cytoplasm for early embryonic support.^[10] This criterion supersedes secondary traits like chromosomes or anatomy, as those serve as proxies for gamete production capacity; for instance, gonadal dysgenesis may impair gamete output but does not produce novel gamete morphs.^[2] Evolutionary biologists emphasize that anisogamy's stability stems from disruptive selection, where intermediate gamete sizes confer reproductive disadvantages, preventing the emergence of additional categories.^[11] Empirical surveys of species confirm this binary without exceptions in gamete morphology.^[12] Conditions classified as disorders of sex development (DSDs), such as complete androgen insensitivity syndrome or congenital adrenal hyperplasia, result in atypical phenotypes but align individuals with one gamete type or sterility, not a third sex; no DSD yields gametes defying the small/large dichotomy.^[2]^[10] This gamete-based definition holds across taxa, from mammals to plants, underscoring its universality as the criterion for sexual dimorphism rather than a human-specific construct.^[2] While phenotypic variations abound, they do not erode the binary at the gametic core, which determines reproductive roles and fitness asymmetries.^[12]

Chromosomal and Anatomical Evidence

In humans, sex is chromosomally determined by the presence or absence of the Y chromosome: individuals with 46,XX karyotype develop as females, while those with 46,XY develop as males.^[13] The Y chromosome harbors the SRY gene, which encodes a transcription factor that triggers testis differentiation from the bipotential gonad during the sixth to seventh week of gestation, initiating the male developmental pathway.^[14]^[15] Absent functional SRY expression—as in 46,XX individuals or rare SRY mutations—the default trajectory yields ovarian development and female anatomy.^[14] This genetic dimorphism manifests anatomically in binary primary sex characteristics aligned with reproductive function: males possess testes producing spermatozoa, internal ducts (epididymis, vas deferens, seminal vesicles, prostate) for gamete transport, and external genitalia (penis, scrotum) adapted for insemination; females possess ovaries producing ova, internal structures (fallopian tubes, uterus, upper vagina) for gestation, and external genitalia (vulva, lower vagina, clitoris) adapted for reception and parturition.^[16] These traits exhibit stark dimorphism, with gonadal tissue unambiguously testicular or ovarian in over 99.9% of cases at birth, reflecting the anisogamous binary of large immobile ova versus small mobile sperm.^[17] Chromosomal anomalies, such as Klinefelter syndrome (47,XXY) or Turner syndrome (45,X), occur in roughly 1 in 500 to 1 in 2,500 live births but typically align phenotypically with the binary: XXY individuals develop male anatomy despite sterility, while XO individuals develop female anatomy with ovarian dysgenesis.^[16] Disorders of sex development (DSDs), encompassing chromosomal, gonadal, or anatomical incongruities, have a broad prevalence of 1 in 4,500 to 1 in 5,500 births, but cases of true ambiguity—where sex assignment proves impossible without intervention—affect only about 0.018% of births under rigorous definitions excluding late-onset or cosmetic conditions.^[16]^[17] These rare variations arise from genetic mutations, hormonal disruptions, or environmental factors during critical developmental windows but do not erode the binary norm, as affected individuals retain gametic potential toward one pole or the other and lack a viable third reproductive category.^[17] Empirical data from neonatal screenings and autopsy studies confirm that 99.98% of humans exhibit unambiguous sex congruence across chromosomes, gonads, and genitalia.^[17]

Intersex Variations and Their Limits

Intersex variations, clinically termed disorders of sex development (DSD), encompass congenital conditions in which chromosomal, gonadal, or anatomical development deviates from typical male or female patterns, often resulting in ambiguous genitalia or mismatched internal and external structures. These arise from genetic mutations, hormonal imbalances, or environmental factors disrupting the binary differentiation process initiated by gamete production, but they do not generate novel reproductive categories. The prevalence of clinically significant DSDs, particularly those presenting with ambiguous external genitalia at birth, is estimated at 0.02% to 0.05% of live births, or roughly 1 in 2,000 to 1 in 4,500 cases; broader inclusions of non-ambiguous conditions like Klinefelter syndrome (XXY) or mild congenital adrenal hyperplasia inflate figures to 1.7%, a definition critiqued for conflating mere chromosomal anomalies with true intersex traits that challenge genital dimorphism.^[17]00878-9/fulltext) Fundamentally, intersex conditions preserve the sex binary defined by anisogamy, as no DSD produces a third gamete type or functional dual reproductive capacity; affected individuals either develop toward sperm production (male), ova production (female), or sterility, without viable intermediates. In ovotesticular DSD—the rarest form, comprising about 1% of DSD cases—both ovarian and testicular tissue may coexist, but functional gamete production is typically limited to one type if any, with most individuals infertile due to underdeveloped or non-viable gonads. Similarly, conditions like complete androgen insensitivity syndrome (CAIS) in XY individuals result in female-typical external anatomy despite testicular gonads producing sperm precursors that go unused, underscoring that sex classification aligns with underlying gametic potential rather than phenotypic expression. Peer-reviewed analyses affirm that these variations represent disorders in binary development, not evidence against it, as evolutionary pressures favor dimorphic reproduction over hermaphroditism in mammals.^[6]^[9]^[8] The limits of intersex variations lie in their rarity, infertility, and alignment within binary boundaries: chromosomal complements are overwhelmingly XX (female) or XY (male), with exceptions like mosaicism or chimerism affecting fewer than 0.01% and still yielding only binary gametic outcomes or none. No documented case exists of an intersex individual contributing both sperm and ova to reproduction, reinforcing that DSDs are pathological deviations—often requiring medical intervention for health, not identity—rather than natural expansions of sex categories. Claims portraying intersex as a "spectrum" or third sex, frequently advanced in activist literature, overlook this reproductive criterion and overstate prevalence by including non-reproductive traits, whereas biological definitions prioritize causal mechanisms of gamete dimorphism. Thus, intersex conditions highlight the robustness of the binary, as deviations do not erode the dimorphic foundation essential for species propagation.^[6]^[18]^[8]

Evolutionary and Comparative Biology

Origins in Anisogamy

Anisogamy refers to the production of two distinct gamete types differing markedly in size and function: small, mobile gametes (spermatozoa) produced in large quantities by males, and large, nutrient-rich gametes (ova) produced in smaller numbers by females. This dimorphism forms the foundational basis for the binary distinction between sexes across anisogamous species, including humans, as it establishes two mutually exclusive reproductive roles optimized for fertilization success.^[19]^[20] The evolutionary origins of anisogamy trace back to ancestral isogamous organisms, where gametes were uniform in size, typically in unicellular eukaryotes over a billion years ago. Disruptive selection on gamete size drove the divergence: under conditions of limited fertilization efficiency, intermediate-sized gametes incurred higher fitness costs due to suboptimal competition for mates (small gametes) or provisioning for zygote survival (large gametes), favoring extremes that specialize in quantity-mobility versus quality-investment. Geoffrey Parker's 1972 model formalized this process, positing that gamete competition and zygote viability create opposing pressures, resulting in a stable polymorphism of two gamete classes rather than a continuum or additional types.^[21]^[22]^[19] This binary outcome persists because the disruptive dynamics yield two evolutionarily stable strategies: one maximizing fusion rate through numerous cheap gametes, the other maximizing offspring viability through fewer resource-intensive ones. No viable intermediate or third gamete type emerges under these constraints, as evidenced by mathematical simulations showing convergence to dimorphism across diverse models, even accounting for factors like parthenogenesis or group spawning. In multicellular lineages, such as volvocine algae, anisogamy evolved independently multiple times from isogamy, consistently producing male-female binaries without intermediates dominating.^[23]^[11]^[24] Empirical support comes from comparative biology, where anisogamy correlates with the absence of functional third sexes; for instance, in over 99% of anisogamous species, reproduction relies exclusively on small-male and large-female gametes, reinforcing the causal link to binary sexual systems. While hermaphroditism can precede or coexist with anisogamy in some lineages, the dimorphic gametes still define distinct male and female functions within individuals, preserving the underlying binary logic rather than eroding it.^[25]^[11]^[26]

Sexual Dimorphism in Humans and Mammals

Sexual dimorphism encompasses the morphological, physiological, and behavioral differences between male and female members of a species, arising primarily from anisogamy—the production of small, mobile gametes (sperm) by males and large, nutrient-rich gametes (ova) by females—which imposes divergent reproductive costs and strategies. In mammals, these differences often include male-biased body size, weaponry for intrasexual competition, and physiological adaptations tied to gestation and lactation in females, though the degree varies by mating system and ecology. Recent phylogenetic analyses indicate that while sexual size dimorphism (SSD) is common, male-larger SSD predominates when present, particularly in polygynous species where males compete intensely for access to females, but males are not larger than females in the majority of mammal species overall.^[27]^[28] In humans, sexual dimorphism is evident in body composition, with adult males averaging 10-14 cm taller than females globally; for instance, U.S. data from the National Center for Health Statistics report mean heights of 175.0 cm for men and 161.3 cm for women. Males also possess greater skeletal muscle mass, averaging 33.0 kg compared to 21.0 kg in females, representing 38.4% versus 30.6% of body mass, respectively, a disparity driven by higher testosterone levels promoting muscle hypertrophy and protein synthesis. Upper-body strength in males exceeds that of females by approximately 52% and lower-body by 66%, even when adjusted for lean body mass, reflecting sex-specific hormone influences on muscle fiber type and distribution. Craniofacial structure shows dimorphism, with males exhibiting more robust jaws and brow ridges, while female pelves are wider to accommodate childbirth, underscoring adaptations to reproductive roles.^[29]^[30]^[31]^[32] Brain dimorphism in humans includes a 11% larger average volume in males, persisting from birth and stabilizing in adulthood, though this scales with overall body size differences and does not imply uniform cognitive disparities after adjustment. In other mammals, dimorphism extends to reproductive organs and behaviors; for example, male cetaceans develop enlarged testes for sperm competition in promiscuous systems, while female elephants exhibit minimal SSD with elongated gestation periods. These patterns stem from natural and sexual selection: females invest heavily in offspring via internal fertilization and viviparity, favoring traits for resource acquisition, whereas males prioritize mating success through contest competition or mate choice displays, leading to exaggerated traits like antlers in deer or canine teeth in seals. Costs include higher male mortality from risky behaviors, as seen across mammal taxa where sexual selection correlates with reduced adult male lifespan relative to females.^[33]^[34]^[35]

Trait	Human Male Average	Human Female Average	Mammalian General Pattern
Body Height	175 cm (U.S.)	161 cm (U.S.)	Male-biased in ~45% of species with SSD; absent or reversed in others
Skeletal Muscle Mass	33 kg (38.4% body mass)	21 kg (30.6% body mass)	Males often larger in polygynous species due to competition
Brain Volume	~11% larger than females	Smaller, adjusted for body size	Variable; tied to cognitive demands of reproductive strategies

Reproductive Fitness and Binary Stability

The binary organization of sexes, defined by production of small motile gametes (sperm) versus large nutrient-rich gametes (ova), maximizes reproductive fitness through complementary specialization in anisogamous species. Males evolve to produce vast quantities of inexpensive sperm to increase fertilization chances, while females invest heavily in fewer, high-quality ova to enhance zygote viability, resulting in an asymmetry that disrupts selection against intermediate gamete producers.^[19] This dimorphism emerged from isogamy via disruptive selection, where gametes of median size fail to compete effectively—neither matching the dispersal efficiency of small gametes nor the provisioning capacity of large ones—favoring evolutionary divergence into two distinct peaks.^[36] In mathematical models of gamete competition, this process yields a stable equilibrium with two sexes, as intermediate strategies yield lower per-gamete fitness under frequency-dependent selection.^[19] In mammals, this binary configuration persists due to the high costs of oogenesis and internal gestation, amplifying the fitness benefits of sex-specific adaptations. Sequential hermaphroditism occurs in some fish but is absent in mammals, where simultaneous hermaphroditism would dilute reproductive output by splitting resources between gamete types, reducing overall offspring production relative to gonochoristic (separate-sex) individuals.^[37] Population genetic simulations confirm that once anisogamy evolves, reversion to isogamy or intermediate forms is improbable, as mutants producing mixed gametes face a twofold fitness cost from inefficient zygote formation and competition with specialized sexes.^[38] Empirical data from vertebrate phylogeny show binary sex evolving convergently over 20+ times, with stability reinforced by chromosomal sex determination (e.g., XY in mammals), which minimizes recombination errors and maintains dimorphic traits under strong selection.^[39] Reproductive success metrics underscore binary stability: in human and mammalian populations, deviations like intersex conditions (affecting ~0.018% of births with unambiguous disorders of sex development) confer reduced fertility, with most sterile or subfertile, illustrating purifying selection against non-binary phenotypes.^[8] Longitudinal studies of fitness in model organisms, such as mice with induced gonadal chimerism, reveal that partial sex reversal lowers lifetime reproductive output by 30-50% compared to binary controls, as hybrid gonads inefficiently produce viable gametes.^[8] Thus, the binary endures as an evolutionarily stable strategy, where the net fitness gain from dimorphic specialization outweighs costs of maintaining two sexes, including the twofold disadvantage relative to hypothetical asexuals—a threshold crossed via advantages in genetic recombination and adaptation.^[38]

Historical Development

Ancient and Pre-Modern Conceptions

In ancient Mesopotamian societies, such as Sumer around 2000 BCE, the foundational conception of human sex was binary, comprising males and females distinguished by reproductive anatomy and roles, with social norms enforcing behaviors aligned to these categories. Priestly figures like the gala, who were biologically male but adopted effeminate dress and roles in temple rituals, were not viewed as a third sex but as anomalous males performing specific cultic functions, often involving castration or passive sexual roles; such deviations were tolerated in religious contexts but did not challenge the male-female binary as the normative structure for kinship and reproduction.^[40] Ancient Egyptian texts and art from the Old Kingdom (c. 2686–2181 BCE) onward depicted sex dimorphism as binary, with gods, pharaohs, and commoners categorized strictly as male or female based on genitalia and procreative capacity, as evidenced in medical papyri like the Edwin Smith Papyrus (c. 1600 BCE), which described surgical interventions for male and female reproductive organs without reference to intermediate categories. Rare intersex conditions were treated as deformities requiring correction to fit binary norms, reflecting a causal understanding rooted in observable fertility differences rather than fluid identities.^[40] In classical Greece, from the Archaic period (c. 800–480 BCE), thinkers like Hippocrates in On the Nature of Man (c. 400 BCE) framed sex as a binary opposition derived from humoral balances, with males exhibiting hotter, drier constitutions suited for active roles and females cooler, wetter ones for gestation, a view empirically tied to anatomical dissections and reproductive outcomes. Aristotle, in Generation of Animals (c. 350 BCE), formalized this as a dimorphic binary where males contributed form via semen and females matter via menstrual blood, dismissing hermaphroditism as mythical or pathological rather than normative, influencing subsequent Western conceptions until the scientific revolution.^[41] Roman law and philosophy, building on Greek foundations, codified the binary in the Twelve Tables (c. 450 BCE, adapted in Roman Republic) and later Justinian Code (c. 533 CE), where citizenship, inheritance, and marriage were predicated on clear male-female distinctions, with intersex individuals (hermaphroditi) legally assigned to one sex based on predominant traits to preserve binary social order. Effeminate males (cinaedi) faced stigma as deviations but were still classified biologically male, underscoring the primacy of reproductive binary over behavioral variance.^[41] In ancient China, Confucian texts like the Book of Rites (c. 200 BCE–200 CE) and medical compendia such as the Huangdi Neijing (c. 200 BCE) conceived sex as a binary manifestation of yin (female, receptive) and yang (male, active) principles, interdependent yet distinct for cosmic and familial harmony, with anatomical dimorphism—evident in skeletal remains from Han dynasty sites (206 BCE–220 CE)—dictating roles in patrilineal descent without recognition of third categories beyond eunuchs, who were altered males.^[42] Indian Vedic literature, including the Rigveda (c. 1500–1200 BCE), invoked a binary creation myth in the Purusha Sukta where primordial man yielded two sexes for propagation, while legal codes like the Manusmriti (c. 200 BCE–200 CE) enforced binary divisions for marriage and caste, treating hijra—eunuch-like figures in epics—as social outcasts or ritual specialists but rooted in male biology, not a denial of the reproductive male-female dyad.^[41] Pre-modern European conceptions, from medieval Christendom onward, drew on Genesis 1:27 ("male and female created he them") as scriptural warrant for binary sex, reinforced by canon law in Gratian's Decretum (c. 1140 CE), which assigned ambiguous births to the sex enabling procreation, prioritizing empirical fertility over ambiguity; this persisted through the Renaissance, as seen in Vesalius's De Humani Corporis Fabrica (1543), which illustrated binary genital anatomy from dissections.^[41]

Enlightenment to 20th-Century Biology

The Enlightenment marked a shift toward empirical classification in biology, with Carl Linnaeus formalizing the binary distinction of sexes in his Systema Naturae (10th edition, 1758), where organisms were grouped by reproductive organs: males producing small, mobile gametes and females larger, nutrient-rich ones, a framework applied to animals including humans as distinctly dimorphic.^[43] This taxonomic approach, rooted in observable anatomy and function, supplanted pre-modern humoral theories of fluid sex gradations, emphasizing reproduction as the causal basis for two sexes essential for species propagation. Linnaeus's system, while focused on plants' stamen-pistil counts, extended binary sexual criteria to vertebrates, aligning with dissections revealing gonadal dimorphism—testes in males and ovaries in females—as the defining trait.^[44] In the 19th century, Charles Darwin built on this foundation in The Descent of Man, and Selection in Relation to Sex (1871), positing sexual selection as a mechanism amplifying dimorphism within a binary sex framework, where males typically competed intrasexually for female mates, yielding traits like larger size or ornamentation in one sex. Darwin documented human dimorphism—males averaging 10-15% taller and stronger than females across populations—attributing it to ancestral selection pressures favoring reproductive variance between sexes, with no intermediate categories disrupting gamete-based duality.^[45] Contemporary anatomists, analyzing skeletal remains from 19th-century European and American samples, quantified dimorphism in metrics like pelvic breadth (wider in females for gestation) and cranial robusticity (greater in males), confirming binary patterns invariant across ethnic groups studied.^[46] These findings, drawn from comparative morphology, reinforced sex as a stable, bimodal distribution tied to fitness outcomes, countering speculative environmental theories of sex plasticity.^[47] Early 20th-century cytology advanced this binary model through the identification of heteromorphic chromosomes governing sex. Clarence McClung proposed in 1902 that an "accessory chromosome" (later X/Y) determined maleness in insects, a hypothesis validated by Nettie Stevens's 1905 observations in mealworms, where males possessed an odd chromosome pair unlike females' even set.^[42] Extended to mammals by 1910s studies on Drosophila and rodents, this revealed XY heterogamy in males versus XX homogamy in females, mechanistically linking genetic dimorphism to gonadal development and gamete production without viable intermediates. By the 1920s-1930s, endocrinological research, including experiments on frog larvae by Friedrich Gudernatsch (1910s), demonstrated hormones reinforcing binary differentiation from indifferent embryonic stages, with disruptions yielding sterile anomalies but not third sexes.^[9] This era's consensus held sex as binarily determined by gametic function and chromosomal triggers, underpinning reproductive isolation in dioecious species like humans.^[6]

Post-1950s Genetic Discoveries

In the mid-20th century, advancements in cytogenetics solidified the XX/XY chromosomal basis of sex determination in humans, with the Y chromosome identified as carrying a male-determining factor by 1959.^[48] This built on earlier observations of sex chromatin (Barr bodies), where females exhibit one inactivated X chromosome per cell, compensating for gene dosage differences between XX and XY individuals.^[49] These findings underscored a binary mechanism: the presence of a functional Y chromosome directs gonadal development toward testes, while its absence results in ovaries, with no viable genetic intermediates capable of producing both small and large gametes.^[50] A pivotal insight came in 1961 when Mary Lyon proposed the hypothesis of random X-chromosome inactivation in female mammals, explaining variegated phenotypes in heterozygous X-linked mutants, such as mottled fur in mice.^[51] This process, occurring early in embryonic development, silences one of the two X chromosomes in each cell via epigenetic mechanisms, including the non-coding RNA Xist, ensuring equivalent X-linked gene expression between sexes.^[52] Lyon's model reinforced the binary framework by highlighting that female development relies on monoallelic expression akin to males, rather than additive or spectral variation, and has been experimentally validated across mammals, including humans.^[53] Molecular genetics advanced this understanding dramatically with the 1990 identification of the SRY (sex-determining region Y) gene on the Y chromosome as the primary testis-determining factor.^[54] Located near the pseudoautosomal boundary, SRY encodes a transcription factor that initiates Sertoli cell differentiation in the bipotential gonad around week 6 of human gestation, triggering a cascade of downstream genes like SOX9 for male pathway activation.^[55] Mutations in SRY cause XY gonadal dysgenesis, resulting in female phenotype despite Y presence, while rare XX translocations incorporating SRY produce male development, demonstrating its causal, binary role without gradient effects.^[56] Subsequent research confirmed SRY's evolutionary novelty, emerging roughly 130-180 million years ago in therian mammals, as the master switch distinguishing male from female reproductive tracts.^[57] These discoveries collectively affirm sex as a dimorphic trait rooted in genetic triggers that canalize development into mutually exclusive male (sperm-producing) or female (oocyte-producing) outcomes, with disorders of sex development (DSDs) representing rare perturbations—such as SRY deletions or chromosomal aneuploidies (e.g., 45,X Turner or 47,XXY Klinefelter syndromes)—that do not generate functional third gamete types or blur the binary at the population level.^[58] Empirical data from genomic sequencing shows over 99.98% of humans conform to XX female or XY male karyotypes, with DSD prevalence below 0.02%, underscoring the stability of this system rather than a continuum.^[48] No post-1950s genetic evidence has identified mechanisms for intermediate sexes producing viable, dual-function gametes in humans or other mammals.^[59]

Cross-Cultural Universality of Dimorphism

Sexual dimorphism, characterized by average differences in male and female body size, strength, and reproductive anatomy, manifests consistently across human populations, with males typically exhibiting greater upper-body strength (approximately 50-60% more than females) and height disparities of 7-15% globally.^[3] These traits stem from anisogamy and sexual selection pressures, observable in skeletal remains and living populations from diverse environments, including equatorial hunter-gatherers and high-latitude pastoralists.^[60] Ethnographic data from the Human Relations Area Files (HRAF), covering over 400 societies, confirm that no preindustrial human group lacks recognition of these binary physical distinctions, which inform social organization rather than being culturally erased or spectrum-ized.^[61] Cross-culturally, sexual dimorphism underpins a universal division of labor, with males predominantly handling high-risk, strength-demanding tasks like big-game hunting and warfare (performed by men in 100% of sampled foraging societies), while females focus on child-rearing and gathering, activities compatible with pregnancy and lactation.^[62] This pattern holds in the Standard Cross-Cultural Sample of 186 societies, where sex-based task allocation is invariant despite variations in female subsistence contributions (ranging from 30-80% of calories in some groups).^[63] Anthropological reviews attribute this stability to causal links between dimorphic traits—male muscle mass for provisioning/defense and female fat reserves for gestation—and survival fitness, rather than arbitrary cultural constructs.^[64] Social expressions of dimorphism, such as sex-segregated rituals, adornment, and mate selection cues, further evidence universality; for instance, male displays of physical prowess and female emphasis on fertility signals appear in initiation rites and courtship across African, Asian, and Indigenous American groups.^[65] Variations in dimorphism magnitude (e.g., reduced stature gaps in high-contribution female economies) do not negate the binary framework, as evidenced by phylogenetic analyses showing consistent directional differences tied to reproductive roles, not cultural relativism. Claims of non-binary cultural exceptions, often amplified in biased academic narratives, lack empirical support in comprehensive databases like HRAF, where intersex rarities (affecting <0.02% reproductively) do not disrupt societal binary norms.^[66]

Gender Roles in Traditional Societies

In hunter-gatherer societies, which represent the longest phase of human prehistory spanning approximately 95% of Homo sapiens' existence until around 10,000 BCE, a consistent sexual division of labor emerged, with males primarily responsible for hunting large game and engaging in high-risk activities requiring mobility and strength, while females focused on gathering plant resources, small game procurement, and childcare proximate to camps. This pattern holds across ethnographic data from over 100 foraging groups studied in the 20th century, such as the Hadza and Aka, where male hunting contributions averaged 60-80% of caloric intake from animal protein, constrained by female reproductive demands including pregnancy and nursing that limited long-distance travel.^[67]^[68] Biological factors, including average male upper-body strength exceeding female by 50-60% and the energetic costs of gestation (adding 50,000-80,000 kcal per pregnancy), underpin this division, as evidenced by cross-species comparisons in primates and early hominids where similar anisogamy-driven roles appear.^[69] While exceptions exist—such as occasional female participation in communal hunts among groups like the Agta, comprising about 5-10% of cases in global samples—these do not overturn the predominant binary structure, as meta-analyses confirm that 79% of foraging societies restrict big-game hunting to males due to physical and opportunity costs.^[70]^[71] In parallel, female roles emphasized sustainability and reliability, with gathering providing 60-70% of daily calories in most cases, fostering complementary interdependence that reinforced sex-based specialization rather than interchangeability.^[72] This arrangement correlates with lower inter-sex conflict and higher reproductive success, as modeled in evolutionary simulations where deviated roles reduce offspring survival by 20-30%.^[73] With the Neolithic transition to agrarian societies post-10,000 BCE, gender roles rigidified further, particularly in plough-based farming systems dominant in Eurasia and Africa, where men monopolized heavy tillage and plowing—tasks infeasible for women during peak reproductive years—while women handled domestic processing, weaving, and subsidiary cultivation. Ethnographic and historical data from 200+ traditional farming communities show female field labor dropping to under 20% in plough cultures versus 40-50% in hoe-based ones, perpetuating norms of male provision and female homemaking that persisted into the 20th century.^[74]^[75] Such divisions, rooted in technological complementarity to sexual dimorphism, explain persistent cross-cultural patterns: in 85% of pre-industrial societies cataloged by the Human Relations Area Files, warfare and herding fell to males, while childcare and food preparation remained female domains, with deviations rare and often linked to ecological niches like matrilineal horticulture in select Pacific islands.^[76]^[77] These roles, while adaptive to survival imperatives, exhibited near-universal binary framing across continents, from Inuit patrilineal hunts to Bantu patrilocal farms, underscoring causal links to reproductive biology over cultural invention alone; anthropological reviews note that even in ostensibly egalitarian foragers, sex predicts 70-90% of task variance, challenging constructivist claims of pure social origin.^[78] Variations, such as higher female autonomy in bilateral kinship systems, modulated but did not erase dimorphic cores, as evidenced by longitudinal studies showing role reversion under stress like famine.^[79]^[80]

Influence on Language, Education, and Institutions

The concept of the gender binary, rooted in biological sex distinctions, has profoundly shaped linguistic structures across human societies. In many languages, grammatical gender systems classify nouns into masculine and feminine categories, often aligning with biological sex for animate referents such as humans and animals.^[81] This alignment traces back to ancient linguistic traditions, as evidenced in Latin where grammatical gender was explicitly connected to perceived biological sex, influencing how speakers categorized and described the world.^[82] Similarly, 19th-century philologist Jacob Grimm argued for an original linkage between grammatical gender and biological sex in Indo-European languages, positing that such systems evolved from natural dimorphism rather than arbitrary convention.^[83] Pronominal systems reinforce this binary, with he/she (or equivalents) universally designating male and female in gendered languages, reflecting cross-cultural recognition of reproductive dimorphism in communication.^[84] In education, the binary has historically manifested through sex-segregated schooling, prevalent in traditional societies to accommodate dimorphic learning differences and social roles. Early modern Europe widely adopted single-sex schools, as boys and girls were prepared for distinct societal functions, a practice extending cross-culturally in pre-colonial Asia and the Middle East where education often separated sexes to align with reproductive and occupational realities.^[85] For instance, until the 1980s, South Korea and Australia maintained significant single-sex enrollment, with outcomes showing varied academic benefits tied to biological variances in maturation rates and spatial abilities.^[86] Empirical reviews indicate mixed but context-specific advantages, such as reduced gender stereotyping in some single-sex environments, though coeducation has dominated post-20th century in Western systems without fully eradicating binary-informed curricula like sex-specific biology instruction.^[87] Institutional policies worldwide have codified the binary to address biological imperatives, particularly in facilities, sports, and family law. Sex-segregated bathrooms and locker rooms, permitted under U.S. Title IX since 1975, stem from privacy and safety concerns rooted in anatomical differences, with courts upholding such separations as constitutional to prevent cross-sex exposure risks.^[88] In sports, binary categories emerged to mitigate male physiological advantages—averaging 10-50% greater strength post-puberty—ensuring competitive equity, as affirmed in policies like the 2025 U.S. Olympic Committee's transgender exclusion from women's events.^[89] Marriage laws historically enforce binary complementarity for reproductive stability, defining unions as male-female in over 90% of global jurisdictions as of 2020, reflecting causal links to gamete dimorphism rather than social constructivism.^[90] These structures persist despite ideological challenges, as deviations often yield empirical issues like increased injury rates in mixed-sex contact sports.^[88]^[91]

Scientific Debates and Empirical Challenges

Arguments for Sex as Spectrum

Proponents of conceptualizing biological sex as a spectrum emphasize the multifaceted nature of sex determination, arguing that it encompasses not only gamete production but also genetic, gonadal, hormonal, and anatomical dimensions that frequently exhibit discordance and variability. According to this view, strict binary classification overlooks cases where these traits do not align neatly into male or female categories, as seen in differences of sex development (DSDs), thereby supporting a model of continuous variation rather than discrete poles.^[7]^[92] A primary empirical argument centers on the incidence of DSDs, which proponents claim affects a significant minority of the population and challenges binary norms. Biologist Anne Fausto-Sterling estimated in 2000 that approximately 1.7% of live births involve conditions qualifying as intersex, including chromosomal variations like Klinefelter syndrome (47,XXY karyotype, occurring in about 1 in 500 to 1,000 male births) and Turner syndrome (45,X karyotype, in about 1 in 2,000 female births), as well as true gonadal intersex (ovotesticular DSD, rarer at around 1 in 20,000 to 100,000 births).^[17] These conditions can result in atypical gonadal tissue, such as ovotestes, or mismatched external and internal genitalia, which Fausto-Sterling argued necessitate recognizing additional sexes beyond male and female, like "herm" or "ferrm." Hormonal profiles provide another line of evidence, with advocates noting that levels of sex steroids like testosterone and estrogen vary continuously across populations rather than forming sharp bimodal peaks. For instance, complete androgen insensitivity syndrome (CAIS) in 46,XY individuals leads to female-typical external development despite XY chromosomes and internal testes, due to non-functional androgen receptors, illustrating how hormonal responsiveness can decouple phenotypic sex from genetic markers.^[92] Similarly, congenital adrenal hyperplasia (CAH) in 46,XX individuals elevates androgens, causing virilization of genitalia in about 1 in 14,000 births, which proponents interpret as evidence of sex traits distributed along a gradient influenced by prenatal hormone exposure.^[93] Genetic mosaicism and environmental factors further underpin spectrum arguments, as sex-determining genes like SRY on the Y chromosome can be absent, translocated, or variably expressed, leading to chimeric tissues where cells differ in sex chromosome complement. Anthropologist Agustín Fuentes, in his 2025 analysis, contends that evolutionary pressures have produced overlapping trait distributions between sexes in mammals, including humans, where no single criterion—chromosomes (present in 99.98% of cases as XX or XY), gametes, or morphology—unambiguously binaries all individuals, rendering the model biologically reductive. This perspective, echoed in reviews of toxicology and endocrinology, posits that incorporating spectrum thinking better accounts for health outcomes varying by sex-related traits, such as drug metabolism differences tied to hormone gradients.^[93]

Rebuttals from Reproductive Biology

Reproductive biology defines sex according to the type of gamete an organism is organized to produce, with males producing small, mobile gametes (sperm) and females producing large, immobile gametes (ova), establishing a binary distinction essential for sexual reproduction via anisogamy.^[2] This gamete-based criterion, rooted in evolutionary principles, precludes a third sex category, as no functional intermediate or alternative gamete type exists in humans or other sexually reproducing species.^[8] Arguments portraying sex as a spectrum often invoke variability in secondary traits like hormones or genitalia, but these do not alter the binary reproductive roles, which remain discretely partitioned without overlap in gamete production capacity.^[6] Disorders of sex development (DSDs), sometimes mischaracterized as evidence for a sex spectrum, represent rare developmental anomalies—occurring in approximately 0.02% of live births for cases with ambiguous external genitalia—where chromosomal, gonadal, or anatomical features fail to align typically, yet individuals retain a binary sex classification based on gonadal tissue or gamete production potential.^[94] In true hermaphroditism (ovotesticular DSD), for instance, affected individuals possess both ovarian and testicular tissue but do not produce functional gametes of a novel type; fertility, when possible, aligns with one binary sex, and such cases do not constitute a third reproductive category.^[6] Empirical data confirm that DSDs disrupt but do not erase the binary: over 99.98% of humans conform to male or female reproductive anatomy without ambiguity, and even in DSDs, medical interventions aim to align with underlying gonadal sex rather than create a spectrum endpoint.^[8] Proponents of a sex spectrum, including some in academia, argue that hormonal mosaicism or chromosomal variations (e.g., XXY Klinefelter syndrome) blur boundaries, but reproductive biology counters that these are binary deviations—males with impaired spermatogenesis or females with atypical development—without evolutionary or functional equivalence to a third sex, as reproduction requires binary gamete fusion.^[2] Sterility in DSDs, analogous to infertility in otherwise binary individuals (e.g., due to age or injury), does not redefine sex; classification persists via the organism's developmental program toward one gamete type, verifiable through histology and genetics.^[95] This framework withstands scrutiny from first-principles: sexual reproduction's selective pressures favor dimorphism for gamete specialization, rendering spectrum claims incompatible with observed causal mechanisms in gametogenesis and fertilization.^[1]

Brain Sex and Hormonal Dimorphism Studies

Studies of human brain structure have identified consistent sexually dimorphic patterns, with males exhibiting approximately 10-12% larger total brain and intracranial volumes from birth onward, even after adjusting for body size.^[96] These differences extend to regional variations, such as greater male volumes in areas like the amygdala and hypothalamus, and relative female advantages in cortical thickness and certain language-related regions, as confirmed by meta-analyses aggregating MRI data from thousands of participants.^[97] Functional connectivity also shows sex-specific patterns, with males displaying stronger inter-network connectivity in large-scale analyses of resting-state fMRI.^[98] Such dimorphisms emerge early, with prenatal and postnatal growth trajectories differing by sex, males showing accelerated volumetric increases in subcortical structures.^[99] Gonadal hormones, particularly testosterone, drive these structural dimorphisms through organizational effects during critical developmental windows. Prenatal testosterone surges in males masculinize brain regions like the cortex and hippocampus, altering cell death, synaptogenesis, and connectivity in sex-specific directions, as evidenced by animal models and human studies of conditions like congenital adrenal hyperplasia (CAH), where elevated fetal androgens in females produce male-like brain patterns.^[100] In typical development, amniotic fluid testosterone levels measured in utero predict sexually dimorphic gray matter volumes in regions such as the right temporoparietal junction, congruent with male-typical trajectories.^[101] Gene regulation by androgen and estrogen receptors further underlies these differences, with knockout studies in mice demonstrating that hormone signaling establishes neural circuits for dimorphic behaviors like aggression and parental care, patterns partially conserved in humans.^[102] Postnatally, circulating sex hormones continue to modulate brain microstructure, correlating with gray matter volumes in hypothalamic and limbic areas.^[103] The "brain mosaic" hypothesis, advanced by Daphna Joel and colleagues, posits that individual brains combine "male-typical" and "female-typical" features without forming two distinct classes, based on analyses showing substantial overlap in single brain traits across sexes.^[104] However, methodological critiques highlight flaws, including reliance on univariate features that ignore multivariate interactions; machine learning classifiers using multiple structural and connectivity metrics achieve over 90% accuracy in sex prediction, indicating underlying dimorphic clusters rather than pure mosaics.^[105]^[106] Even proponents acknowledging overlap, such as in reviews attributing many differences to overall size scaling, concede reproducible dimorphisms in hormone-sensitive regions like the hypothalamus, which align with reproductive and behavioral divergences between sexes.^[33] Cross-species comparisons reinforce this, showing conserved sex effects on brain anatomy driven by hormonal dimorphism, challenging spectrum interpretations by emphasizing binary gonadal influences on neural organization.^[107] Transcriptomic data from early fetal brains further reveal sex-biased gene expression influenced by sex chromosomes and hormones, supporting causal dimorphism over mosaic variability.^[108]

Recent Polls and Consensus Among Biologists (2023-2025)

In a survey of 179 scientists across disciplines at UK universities, conducted in early 2024 by The Telegraph and Censuswide, 58% of respondents stated that biological sex is binary, 29% disagreed, and the remaining 13% were undecided or did not know.^[109] ^[110] Life sciences faculty, including biologists, represented 12% of the sample, while social sciences accounted for 18%; the higher dissent rate in non-biological fields suggests field-specific differences in adherence to gamete-based definitions of sex.^[111] No large-scale polls exclusively targeting biologists emerged between 2023 and 2025, but expert commentary from the field reinforces a strong consensus on the binary nature of human sex, grounded in anisogamy—the production of either small gametes (sperm) or large gametes (ova), with no viable third category observed in mammals.^[112] In April 2023, evolutionary biologist Colin Wright emphasized in The Wall Street Journal that this binary holds across sexually reproducing species, including humans, where disorders of sex development (DSDs) represent developmental anomalies rather than intermediate sexes.^[112] Similarly, a June 2025 analysis by geneticist Ricki Lewis critiqued non-binary redefinitions as diverging from empirical reproductive criteria, attributing such shifts to policy influences rather than biological evidence.^[113] This biological consensus persists despite vocal minorities in academia, where surveys indicate ideological pressures may inflate non-binary views; for instance, the 2024 UK poll's 29% dissent aligns with broader patterns of left-leaning bias in higher education, potentially prioritizing social constructs over gametic dimorphism.^[114] Leading reproductive biologists, such as those contributing to the National Association of Scholars, maintain that human sex classification remains immutable and binary for 99.98% of the population, with DSDs affecting fertility but not erasing the underlying dichotomy.^[8] No peer-reviewed surveys from 2023–2025 contradict this foundational view among specialists in human developmental biology.

Psychological and Identity Dimensions

Innate Gender Identity vs. Biological Sex

Biological sex in humans is dimorphic and binary, defined by the production of small gametes (sperm) in males or large gametes (ova) in females, a distinction rooted in reproductive anatomy and genetics with rare disorders of sex development (DSDs) representing 0.018% to 1.7% of births but not constituting additional sexes.^[9] Gender identity, by contrast, refers to an individual's subjective sense of being male, female, or otherwise, with proponents of innate gender identity asserting it as a biologically fixed trait potentially discordant from biological sex, akin to an internal "brain sex" mismatch.^[115] Empirical support for this innateness remains limited, as self-reported identity lacks objective biomarkers and correlates more with psychological factors than immutable biology.^[116] Twin studies provide moderate evidence of heritability for gender dysphoria, with estimates ranging from 11% to 62% across samples, indicating genetic influences but substantial environmental and non-shared factors, as monozygotic concordance rates fall short of 100% and dizygotic pairs show lower but non-zero similarity.^[117]^[118] For instance, a 2022 Danish registry study of over 500,000 twins estimated heritability at around 25-47% for transgender identity, comparable to complex traits like personality but insufficient to establish a deterministic biological basis overriding sex.^[118] Hormonal and genetic research, such as prenatal androgen exposure effects, suggests contributions to gender nonconformity but fails to identify specific variants predicting persistent identity discordance across populations.^[119] Brain imaging studies from 2020-2025 reveal average sex differences in structure and connectivity—e.g., larger male total brain volume and female-adjusted gray matter proportions—but transgender individuals' brains exhibit mosaics of traits with significant overlap between sexes, not a categorical shift to the opposite sex configuration.^[120]^[121] Claims of "feminized" brains in trans women or vice versa often rely on small, non-representative samples and post-hoc interpretations, undermined by plasticity effects from hormones or lifestyle; a 2025 review critiques these as failing to differentiate innate identity from adaptation.^[122] Longitudinal data further challenge innateness: among children with gender dysphoria, desistance rates reach 61-98% by adolescence or adulthood, with persistence linked to intensity and co-occurring conditions like autism rather than fixed biology.^[123]^[124] From a causal realist perspective, biological sex emerges from evolutionary pressures for reproduction, rendering it immutable post-development, while gender identity appears malleable and influenced by social, cultural, and experiential variables, with discordance rates under 0.6% in adults suggesting rarity not explained by a robust innate mechanism.^[125] Peer-reviewed critiques highlight methodological flaws in pro-innate studies, including publication bias in gender-affirming research, underscoring the need for skepticism toward claims diverging from reproductive dimorphism.^[116]^[126] Thus, while partial biological underpinnings exist, evidence does not substantiate gender identity as an independent, innate binary overriding sex, aligning instead with sex as the primary causal determinant.

Rates of Gender Dysphoria and Outcomes

Gender dysphoria, defined clinically as significant distress arising from incongruence between one's experienced gender and biological sex, exhibits low prevalence in population-based studies. Historical estimates from the DSM-5 indicate rates of 0.005% to 0.014% among biological males and 0.002% to 0.003% among biological females in clinical settings.^[127] Recent diagnostic data reveal sharp increases, with U.S. diagnoses among children and adolescents aged 6-17 rising to approximately 42,000 cases in 2021, reflecting a near-doubling from the previous year.^[128] In England, recorded incidence escalated from 0.14 per 10,000 in 2011 to 4.4 per 10,000 in 2021, a roughly 30-fold rise, predominantly among adolescent females who showed the steepest increase (12-fold).^[129] ^[130] Longitudinal studies of children referred for gender dysphoria demonstrate high desistance rates, with persistence into adulthood occurring in 2% to 39% of cases. In one follow-up of boys clinically diagnosed with gender identity disorder, 88% desisted by adolescence or adulthood.^[124] Aggregating 11 such studies yields an average desistance rate of 80%, challenging assumptions of stability in youth presentations.^[131] The UK's Cass Review, evaluating evidence for pediatric gender services, underscored methodological weaknesses in affirmation-focused approaches and noted that most gender-related distress in youth resolves without intervention, informed by desistance data and the absence of robust predictors of persistence.^[132] For adults pursuing transition, outcomes include variable regret and persistent mental health risks. Regret rates post-surgery are reported as low (0.3% to 3.8%), though systematic underreporting and loss to follow-up inflate uncertainty, with detransition rates remaining poorly quantified amid rising anecdotal cases.^[133] ^[134] A 42-year Swedish cohort study of 324 individuals post-sex reassignment surgery found suicide attempts 19 times higher than matched controls, with overall mortality elevated due to suicide, cardiovascular issues, and psychiatric morbidity, persisting 10-15 years postoperatively without evidence of risk normalization.^[135] The Cass Review similarly critiqued the low-quality evidence base for long-term benefits, finding no reliable reduction in suicide or improved mental health outcomes from hormones or surgery, alongside high comorbidity rates (e.g., autism, trauma) complicating causal attribution.^[132]

Non-Binary Identifications in Population Data

In the United States, a 2022 Pew Research Center survey estimated that 1.6% of adults identify as transgender or nonbinary, with the proportion rising to approximately 5% among adults under 30.^[136] This figure derives from self-reported data in a nationally representative sample, though nonbinary identifications specifically comprise a subset often below 1% in broader LGBTQ+ breakdowns, as seen in Gallup's 2025 poll where 1.3% of adults identified as transgender overall, with nonbinary not separately quantified but noted as 1-2% in ancillary analyses.^[137]^[138] Among youth, rates appear higher but show signs of decline; a 2025 study of U.S. high school students reported nonbinary identification dropping 3-6 percentage points from 2023 levels, potentially reflecting shifts in social trends or survey response patterns.^[139] In the United Kingdom, the 2021 Census by the Office for National Statistics (ONS) recorded 30,000 individuals—or 0.06% of respondents aged 16 and over—identifying explicitly as nonbinary, within a broader gender-diverse population of about 0.54%.^[140] This official estimate has faced scrutiny for potential overstatement due to question wording that may have conflated temporary questioning with fixed identity, leading the ONS in 2024 to downgrade it from a national statistic amid evidence of local-level inconsistencies and non-response biases.^[141] Academic critiques, including a 2024 analysis in Sociology, argue the data's implausibility stems from an unvalidated voluntary question yielding anomalously high urban concentrations uncorrelated with biological or historical patterns.^[142] Australian Bureau of Statistics (ABS) data from 2022 estimates that nonbinary individuals form about 32.7% of the transgender and gender-diverse population (totaling around 0.5-1% of adults), with higher prevalence among those aged 16-24.^[143] The 2021 Census captured minimal "non-binary" responses to sex questions, often reclassified after follow-up, indicating self-identification rates under 0.1% in mandatory fields but rising in optional gender queries.^[144] Cross-nationally, these figures remain marginal—typically 0.1-0.5% in adult populations—concentrated in younger cohorts and Western contexts, with government surveys like those from the ONS and ABS providing more conservative estimates than advocacy-driven polls due to standardized methodologies and lower social desirability bias.^[143]^[140]

Criticisms, Defenses, and Ideological Conflicts

Proponents of social constructionism assert that gender identities and roles are primarily shaped by cultural norms, socialization processes, and repeated performative acts rather than fixed biological imperatives. This perspective, influential in feminist and postmodern theory, posits that biological sex provides a dimorphic foundation but does not dictate behavioral or identity outcomes, which are instead imposed and reinforced through societal expectations. For instance, Simone de Beauvoir argued in The Second Sex (1949) that "one is not born, but rather becomes, a woman," emphasizing that femininity arises from external conditioning and historical contingencies rather than innate essence.^[145]^[146] Judith Butler extended this framework in Gender Trouble (1990) by introducing the concept of gender performativity, contending that gender is not an internal truth expressed outward but a stylized repetition of acts—such as speech, dress, and gestures—that constitute the illusion of a stable identity. Butler further challenged the naturalness of binary sex categories, suggesting they too are regulatory fictions produced through discursive practices that normalize heterosexuality and marginalize deviations.^[147]^[148] This view implies that biology's role is overstated, with gender differences emerging from power dynamics that construct and enforce binaries to maintain social order.^[149] Advocates cite cross-cultural variability in gender expressions—such as matriarchal societies or historical fluidity in roles—as evidence that socialization overrides biological uniformity, arguing that empirical observations of difference reflect learned behaviors rather than evolved traits. They maintain that interventions like education and policy can reshape these constructs, prioritizing malleability over determinism, though such claims often draw from qualitative analyses in gender studies rather than controlled biological experiments.^[150]^[151] These theories, originating in mid-20th-century existentialist and poststructuralist scholarship, have permeated academic fields like sociology and anthropology, influencing assertions that denying constructionist primacy perpetuates outdated essentialism.^[152]

Evolutionary and Causal Realist Defenses

The binary organization of biological sex in humans and other anisogamous species traces its evolutionary origins to the transition from isogamy (equal-sized gametes) to anisogamy, where natural selection favors gametes specialized for either mobility and quantity (sperm) or immobility and provisioning (ova). This divergence arises through disruptive selection, as gametes of intermediate size confer neither competitive fertilization advantages nor superior zygote survival, rendering them evolutionarily unstable across billions of years of sexual reproduction.^[153]^[2] In vertebrates, including mammals, this mechanism has produced only two viable sexes, with no observed third gamete type capable of independent reproductive contribution, as confirmed by genomic and fossil records spanning over 1.2 billion years.^[8] Causal analyses emphasize that sex classification operates through immutable developmental pathways triggered by genetic cues, such as the SRY gene on the Y chromosome directing testicular development in males around week 7 of gestation, while its absence defaults to ovarian development in females. These pathways converge on gamete production as the proximate criterion for sex, with disorders of sex development (DSDs) representing rare failures (affecting 0.018% to 1.7% of births, depending on definition) in this binary cascade rather than evidence of a spectrum or third category.^[154]^[8] Evolutionarily, maintaining this binary maximizes reproductive fitness by aligning organismal traits—such as body size dimorphism (e.g., human males averaging 10-15% taller and 50% stronger in upper body than females)—with ancestral selection pressures for mate competition and parental investment, as modeled in Bateman's principles and empirical data from over 100 species.^[155]^[156] From a causal realist standpoint, the sex binary is not an arbitrary social imposition but a foundational mechanism enabling sexual reproduction's adaptive advantages, including genetic recombination and outcrossing, without which population-level diversity and resilience collapse, as seen in parthenogenetic species with elevated extinction risks.^[157] Claims of a sex spectrum often conflate variable secondary traits (e.g., hormone levels or genitalia) with primary reproductive roles, but these traits derive causally from the binary gametic foundation, exhibiting bimodal distributions rather than continuous gradients; for instance, testosterone levels cluster distinctly by sex, with overlaps attributable to pathology or age rather than normative variation.^[2]^[154] This perspective aligns with first-principles derivations in evolutionary theory, where sex roles emerge predictably from gametic asymmetry, countering ideologically driven reinterpretations that prioritize subjective experience over empirical reproductive causality.^[8]^[157]

Policy-Driven Erosion and Empirical Counter-Evidence

Policies in several jurisdictions have facilitated the erosion of sex-based protections by permitting gender self-identification without requiring medical or surgical transition, allowing individuals to access facilities and services aligned with their declared gender rather than biological sex. In the United Kingdom, prison policies prior to 2019 permitted male-bodied inmates identifying as female to transfer to women's prisons based on self-declaration, a practice criticized for prioritizing identity over safety assessments. Similarly, proposed reforms to Scotland's Gender Recognition Act in 2022 aimed to enable legal sex changes via statutory declaration alone, potentially extending self-ID to single-sex spaces, though the bill was blocked by the UK government citing risks to women's rights. In sports, organizations like the NCAA have allowed transgender women who underwent male puberty to compete in female categories under hormone therapy guidelines, exemplified by Lia Thomas's participation in women's events after competing on the men's team.^[158]^[159]^[160] Empirical evidence highlights harms from these policies, particularly in prisons where male-bodied offenders have exploited self-ID to access female estates, leading to sexual assaults. The 2018 case of Karen White, a male rapist with prior convictions who self-identified as female, resulted in assaults on two female inmates at HMP New Hall shortly after transfer, prompting policy reviews and underscoring vulnerabilities in women's facilities where inmates report higher rates of trauma from male violence. UK Ministry of Justice data from 2010-2018 recorded seven transgender-related sexual assaults in women's prisons out of 124 total incidents, with critics noting underreporting and the disproportionate risk posed by a small number of transfers—over 125 male-bodied inmates were housed in female prisons by 2019 despite only 1-2% of the prison population identifying as transgender. These outcomes contradict assurances of minimal risk, as biological males retain physical advantages in confined settings, challenging the efficacy of self-ID in safeguarding sex-segregated protections.^[158]^[161]^[162] In athletics, self-ID accommodations have produced measurable unfairness, as male physiological advantages from puberty—such as greater muscle mass and bone density—persist post-hormone suppression, displacing female competitors. Lia Thomas, after ranking 462nd in men's NCAA 500-yard freestyle in 2019, won the women's national title in 2022 with a time 4:33.24, surpassing the field by over a second and erasing prior female benchmarks in the event. Analysis of Thomas's performances shows her post-transition times remained competitive with mid-tier male standards, while dominating female rankings, prompting backlash from athletes like Riley Gaines, who tied for fifth but was awarded fifth place overall. World Athletics and other bodies have since restricted such participation, citing data from over 30 studies on enduring male advantages, with retained edge in strength up to 30% even after years of testosterone suppression. This evidence supports retaining binary categories to preserve fairness, as policy-driven inclusion undermines empirical sex differences central to equitable competition.^[163]^[160]^[164] Broader data on gender-neutral facilities, such as bathrooms, reveal mixed but cautionary patterns, with isolated incidents of voyeurism and assault linked to lax policies, though comprehensive statistics are limited by inconsistent reporting. A 2018 UCLA study found no overall crime spike in trans-inclusive states, but critics argue it overlooks targeted harms to women, as seen in cases like the 2021 Wi Spa incident in Los Angeles where a male exposing himself in the women's area cited self-ID. Government reviews, including Scotland's equality impact assessments, acknowledged potential conflicts with women's sex-based rights without quantifying mitigations, highlighting how ideological prioritization of fluidity over binary realities invites causal risks without proportional benefits. These patterns affirm the binary's role in risk mitigation, as deviations correlate with verifiable inequities rather than societal progress.^[165]^[166]

Societal Impacts and Policy Implications

Healthcare Disparities from Binary Denial

Denial of the biological sex binary in healthcare settings, by prioritizing self-identified gender over immutable physiological sex differences, has contributed to suboptimal screening, dosing, and risk assessment protocols for transgender patients. Medical treatments and diagnostics often rely on binary sex-based norms due to differences in anatomy, hormone profiles, metabolism, and disease prevalence; for instance, prostate-specific antigen (PSA) levels for cancer screening are calibrated differently for males, but hormone therapy in transgender women suppresses PSA, leading to artificially low readings that mask early prostate cancer detection. A 2024 study from the University of California, San Francisco, found that this suppression provides false reassurance, potentially delaying diagnosis and worsening outcomes in transgender women, who retain male prostate tissue despite estrogen use. Similarly, cardiovascular risk models designed for cisgender females underestimate threats in transgender women, who exhibit over twice the prevalence of myocardial infarction compared to cisgender females, with hormone-affirming therapy exacerbating venous thromboembolism and stroke risks beyond female norms.^[167]^[168] In transgender men, conflating gender identity with biological female reproductive capacity has led to overlooked pregnancy risks and inadequate preventive care. Up to 30% of transgender men experience unintended pregnancies, often because testosterone therapy is presumed to eliminate fertility without confirming cessation of menses or providing contraception counseling, resulting in fetal exposure to androgens and potential developmental complications. Those retaining ovaries and uterus require sex-specific cervical and breast cancer screenings aligned with female guidelines, yet dysphoria or provider assumptions of male status can deter adherence, with post-mastectomy protocols lacking evidence-based alternatives like routine chest wall exams or imaging. A 2021 review highlighted that transgender men on testosterone face elevated polycythemia and lipid profile shifts akin to male patterns, but pregnancy outcomes reveal persistent female vulnerabilities, such as gestational diabetes rates comparable to cisgender females if prior hormone cessation is incomplete.^[169]^[170]^[171] Pharmacological disparities arise from sex-dimorphic drug pharmacokinetics, where females generally metabolize certain medications faster due to differences in body composition and liver enzyme activity; assigning female dosing to biological males or vice versa based on identity risks toxicity or inefficacy. A 2020 analysis in the Pharmaceutical Journal warned that conflating sex with gender in prescribing ignores these variances, potentially leading to adverse events like prolonged sedation from anesthetics or suboptimal antibiotic efficacy. Laboratory reference ranges for biomarkers, such as hemoglobin or creatinine, are sex-specific to account for male-female physiological baselines, and overriding them with gender markers can misinterpret results, as seen in transgender patients where hormone-induced shifts confound diagnostics without adjustment for natal sex. These issues underscore empirical needs for sex-based protocols, as evidenced by guidelines from bodies like the Endocrine Society, which still reference biological sex for hormone management despite identity-affirming emphases.^[172]^[173]^[174]

Legal and Sports Applications

In legal contexts, sex is predominantly defined as an immutable biological classification into male or female, grounded in reproductive roles—males producing small gametes (sperm) and females producing large gametes (ova)—across major jurisdictions.^[175]^[176] For instance, as of 2025, U.S. states including Utah, West Virginia, Wyoming, Ohio, and North Carolina have enacted laws explicitly defining sex as binary and biologically determined at birth, often to safeguard sex-based rights and protections under statutes like Title IX.^[177]^[178] A federal executive order issued on January 20, 2025, reinforced this by mandating that "sex" in U.S. policy refers solely to biological male or female, rejecting synonyms with gender identity.^[179] Legal recognition of non-binary categories remains exceptional globally, limited to select nations like Argentina (via decree allowing third-gender IDs since 2021), Germany, India, and Nepal, with the U.S. permitting an "X" marker on passports since April 2022 but maintaining policy emphasis on the binary for equality and differentiation purposes.^[180]^[181] These binary definitions underpin applications in areas requiring sex-based distinctions, such as prisons, bathrooms, and anti-discrimination laws, where conflating biological sex with self-identified gender risks safety and privacy violations, as evidenced by incidents of male-bodied individuals in female facilities post-self-ID policies.^[182] Courts have occasionally struck down expansions of "sex" to include gender identity beyond biology, such as a 2025 federal ruling vacating EEOC guidance that extended Title VII harassment protections outside the biological binary. However, challenges persist, with some rulings invoking Bostock v. Clayton County (2020) to argue gender identity discrimination equates to sex discrimination, though this interpretation is contested for blurring causal distinctions between biological dimorphism and identity.^[183] In sports, the gender binary manifests through sex-segregated categories designed to account for inherent physiological differences, with males typically exhibiting 10-50% advantages in strength, speed, and endurance due to factors like greater muscle mass, bone density, and hemoglobin levels shaped by male puberty.^[184] Peer-reviewed studies confirm these advantages largely persist in transgender women (males post-transition) even after testosterone suppression, retaining elevated performance in metrics such as grip strength, jump height, and aerobic capacity compared to biological females.^[185]^[186]^[187] For example, a 2023 review highlighted minimal loss of male-typical advantages post-hormone therapy, undermining claims of parity.^[188] Governing bodies have increasingly prioritized biological sex for fairness, with World Athletics and similar organizations barring transgender women who underwent male puberty from elite female events since 2023, citing irremediable edges.^[189] In the U.S., the NCAA updated its policy on February 6, 2025, restricting women's divisions to those assigned female at birth, aligning with a February 5, 2025, executive order prohibiting male participation in female sports to preserve competitive integrity.^[190]^[191] Legal challenges to such binary-enforcing measures, including state bans, argue equal protection violations but often overlook empirical data on performance disparities, as seen in ongoing Supreme Court reviews of transgender athlete restrictions.^[192]^[193] These policies reflect causal realism: sex-based segregation mitigates unfair outcomes without broadly excluding transgender individuals from open or male categories.^[194]

Media and Cultural Shifts Toward Fluidity

In the 2010s, mainstream media outlets and entertainment industries began amplifying narratives of gender fluidity, featuring characters and storylines that challenge binary sex-based categories. For instance, television series such as Billions (2016) introduced non-binary characters like Taylor Mason, portrayed without regard to traditional male-female distinctions, while shows like Euphoria (2019 onward) depicted fluid gender expressions among adolescents as normalized explorations.^[195] This trend extended to film, with increased inclusion of gender-diverse roles in productions from studios like Netflix and Disney, often in response to advocacy from groups like GLAAD, which reported a rise from fewer than 10 transgender or non-binary characters in top films in 2015 to over 30 by 2021.^[196] Such portrayals frequently emphasize personal identity over biological markers, aligning with cultural messaging that gender exists on a spectrum independent of sex.^[197] Social media platforms accelerated these shifts, particularly among youth, by facilitating rapid dissemination of fluidity concepts through viral content and influencer testimonials. TikTok and Instagram, dominant since the mid-2010s, hosted challenges and discussions promoting non-binary labels, correlating with self-reported increases in gender-diverse identifications; U.S. surveys indicated youth non-binary identification rose from under 1% in 2017 to approximately 3.5% by 2021, with researchers attributing part of this to online communities providing affirmation and visibility.^[198]^[199] Platforms' algorithms prioritized such content, creating echo chambers that some studies link to heightened gender questioning, though empirical evidence suggests this may reflect social influence rather than innate traits, as evidenced by patterns resembling peer contagion in adolescent mental health trends.^[200] By the early 2020s, news media adopted fluidity-aligned language, with outlets like The New York Times and BBC routinely using terms such as "gender identity" decoupled from biology in reporting, often citing activist sources over biological research. This linguistic shift paralleled policy advocacy, such as inclusive pronoun policies in workplaces and schools promoted via media campaigns. However, recent data indicate a reversal, with U.S. young adult transgender and non-binary identifications dropping nearly 50% from 2023 peaks by late 2025, potentially due to increased scrutiny of media-driven narratives amid rising detransition reports and platform restrictions on youth-targeted content.^[201] These developments highlight how media amplification, while boosting visibility, has faced pushback from empirical observations of desistance rates exceeding 80% in longitudinal studies of youth gender distress, underscoring tensions between cultural promotion and biological realities.^[202]

References

[1]
Gamete Size Is Essential for Understanding Sex and Sexual ...
Aug 12, 2025 · But, biologically speaking, the distinction is quite simple—sexes can be distinguished, across the board, by gamete (or sex cell) size. Sexually ...
[2]
Biological sex is binary, even though there is a rainbow of sex roles
Dec 21, 2022 · Biological sex is binary, but sex roles can be flexible within and among species (Figure 1). For instance, in two-spotted gobies (Gobiusculus ...
[3]
Substantial but Misunderstood Human Sexual Dimorphism Results ...
In anisogamous species, female gametes are larger and thus typically produced in smaller numbers than male gametes. ... The definition of sexual selection. Behav.
[4]
4.9: Sexual dimorphism - Biology LibreTexts
Jan 3, 2021 · The size difference between male and female gametes changes the reproductive stakes for the two sexes. Simply because of the larger size of ...
[5]
How common is lntersex? A response to Anne Fausto‐Sterling
Jan 11, 2010 · The true prevalence of intersex is seen to be about 0.018%, almost 100 times lower than Fausto‐Sterling's estimate of 1.7%.Missing: disorders | Show results with:disorders<|separator|>
[6]
“Intersex” Does not Violate the Sex Binary - PMC - NIH
May 18, 2023 · The XX/XY system is merely the mechanism by which placental mammals like humans typically become female and male; other animals and plants use ...
[7]
Is sex still binary? - PMC - NIH
Recent data indicate that sex is not a simple binary classification based solely on genitalia at birth or reproductive capacity but encompasses various ...
[8]
In Humans, Sex is Binary and Immutable by Georgi K. Marinov | NAS
An excellent discussion, although in the biological weeds at times. Nonetheless, the clarity of the argument is undeniable - sex is binary. What is alarming ...
[9]
Understanding the Sex Binary | City Journal
Mar 20, 2023 · When biologists claim that “sex is binary,” they mean something straightforward: there are only two sexes. This statement is true because an ...Missing: peer- reviewed
[10]
Only two sex forms but multiple gender variants: How to explain?
There are only two types of gametes, sperm cells (spermatozoa) and egg cells. There are no intermediate types of sex cells between sperm- and egg cells. By ...Missing: binary | Show results with:binary
[11]
Hermaphroditic origins of anisogamy - PMC - NIH
Mar 20, 2023 · Anisogamy—the size dimorphism of gametes—is the defining difference between the male and female sexual strategies.
[12]
[PDF] There Are Only Two Sexes and There Can Never Be More
Aug 11, 2025 · In biological science, sex is defined by the gamete morph an organism produces: females produce large gametes (eggs/ova); males produce small ...
[13]
Sex chromosomes & X-linked inheritance (article) - Khan Academy
Human X and Y chromosomes determine the biological sex of a person, with XX specifying female and XY specifying male.
[14]
SRY gene: MedlinePlus Genetics
Sep 28, 2022 · The SRY gene provides instructions for making a protein called the sex-determining region Y protein. This protein is involved in male-typical sex development.
[15]
SRY: Sex determination - Genes and Disease - NCBI Bookshelf - NIH
SRY, or sex-determining region Y gene, is on the Y chromosome and is important for testis formation. It binds to DNA, altering its properties.
[16]
Ambiguous Genitalia and Disorders of Sexual Differentiation - NCBI
Aug 28, 2023 · The incidence of a child with a disorder of sexual development (DSD) is approximately 1 in 1000 to 4500 live births.[13][1] The most frequently ...Introduction · History and Physical · Evaluation · Treatment / Management
[17]
How common is intersex? a response to Anne Fausto-Sterling
The true prevalence of intersex is seen to be about 0.018%, almost 100 times lower than Fausto-Sterling s estimate of 1.7%.
[18]
How common is lntersex? A response to Anne Fausto‐Sterling
Aug 5, 2025 · [2] Estimating DSD incidence is challenging, with prevalence approximated at 1 in 4500-5500 newborns and 1 in 20,000 births for individuals with ...
[19]
The Legacy of Parker, Baker and Smith 1972: Gamete Competition ...
Mar 5, 2021 · The two central drivers of gamete dimorphism in the disruptive selection theory of Parker, Baker and Smith [1] are gamete competition (i.e. ...
[20]
Evolution of Anisogamy in Organisms with Parthenogenetic Gametes
The current model shows that large isogamy can evolve when parthenogenetic gametes evolve under conditions of inefficient fertilization.Abstract · Models · Results · Discussion
[21]
The origin and evolution of gamete dimorphism and the male-female ...
The classical theory suggests anisogamy arises from disassortative fusions. Initially, females with assortative fusions may be favored, but males with sperm ...
[22]
The evolution of anisogamy: a game-theoretic approach - Journals
A popular theory has proposed that anisogamy originated through disruptive selection acting on an ancestral isogamous population.
[23]
Evolutionary trajectories explain the diversified evolution of isogamy ...
Aug 6, 2012 · It is generally agreed that the evolutionary antecedents of anisogamy can be traced to isogamy with small gametes (1–6). The evolution of ...
[24]
Hermaphroditic origins of anisogamy - Journals
Mar 20, 2023 · We show that hermaphroditic anisogamy can evolve directly from isogamous ancestors when the average size of spawning groups is small and fertilization is ...Abstract · Introduction · Methods · Discussion
[25]
The evolution of sexes: A specific test of the disruptive selection theory
Nov 26, 2017 · The Bulmer and Parker (2002) game-theoretic model provides the most complete description of the disruptive selection theory of the evolution of ...
[26]
The origination events of gametic sexual reproduction and anisogamy
Aug 19, 2022 · Some theoretical works have suggested that multicellularity promotes the evolution of anisogamy from isogamy (Bulmer and Parker 2002; Lehtonen ...
[27]
New estimates indicate that males are not larger than females in ...
Mar 12, 2024 · Although males tend to be larger than females when dimorphism occurs, males are not larger in most mammal species, suggesting a need to revisit other ...
[28]
The macroevolutionary dynamics of mammalian sexual size ...
Nov 15, 2023 · Mammals are unusual in primarily displaying male-biased SSD, where males of a species are typically larger than females.
[29]
Body Measurements - FastStats - CDC
Men: Height in inches: 68.9. Weight in pounds: 199.0. Waist circumference in inches: 40.6; Women: Height in inches: 63.5. Weight in pounds: 171.8
[30]
Average height for men and women worldwide - Worlddata.info
In the US, the average male is 1.77 m tall. The average US-american woman reaches 14 cm less with a height of 1.63 m.
[31]
Skeletal muscle mass and distribution in 468 men and women aged ...
Men had significantly (P < 0.001) more SM in comparison to women in both absolute terms (33.0 vs. 21.0 kg) and relative to body mass (38.4 vs. 30.6%).
[32]
Gender differences in strength and muscle fiber characteristics
The women were approximately 52% and 66% as strong as the men in the upper and lower body respectively. The men were also stronger relative to lean body mass.
[33]
Dump the “dimorphism”: Comprehensive synthesis of human brain ...
Males' brains are larger than females' from birth, stabilizing around 11 % in adults. This size difference accounts for other reproducible findings.
[34]
Mammalian sexual dimorphism - ScienceDirect
Thus the aim of this review is to discuss current knowledge relating to the evolution, benefits and costs of mammalian sexual dimorphisms and, where possible, ...
[35]
Sexual selection drives sex difference in adult life expectancy across ...
Oct 1, 2025 · Like humans, 72% of mammals exhibited a female life expectancy advantage, while 68% of birds showed a male advantage, as expected from the ...Sexual Selection Drives Sex... · Results · Sex Differences In Ale
[36]
The origin and evolution of gamete dimorphism and the male-female ...
... disruptive effect can be generated in which the two extremes, (large and small gamete production) are favoured. Reasons are given why selection should ...
[37]
Evolution of the Two Sexes under Internal Fertilization and ...
... (Parker et al. 1972): anisogamy arises from isogamy by disruptive selection favoring individuals producing large gametes (which survive well as zygotes) and ...
[38]
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0006012
[39]
Apparent independent and multiple evolution of binary sex
Feb 14, 2025 · Anisogamy is often taken as the defining difference between 'male' and 'female' sexual strategies: males produce only sperm; females produce ...
[40]
Gender in the Ancient Near East and Egypt - ANE Today
Nov 2, 2023 · The societies of the ancient Near East had a binary sex paradigm—female and male— and had notions of how these two sexes were supposed to be and ...
[41]
Gender as a historical kind: a tale of two genders? - PubMed Central
Mar 16, 2018 · Most of us live in a culture in which gender is understood as a binary matter: you are either a woman or a man; you are either a girl or a boy.
[42]
A brief history of sex determination - ScienceDirect
We present a brief history of sex determination studies from ancient times until today, by selectively interviewing some of the milestones in the field.Missing: civilizations | Show results with:civilizations<|separator|>
[43]
Linnaeus' taxonomy and the roots of scientific bias - Frontline
Oct 2, 2024 · His plant classification system, based on sexual characteristics, reinforced binary gender concepts and facilitated colonial botanical ...
[44]
Linnaeus and Race | The Linnean Society
Sep 3, 2020 · In 1735, the class into which Linnaeus inserted man was called Quadrupeds, and the order, Anthropomorpha. These names Linnaeus would change to ...Missing: binary | Show results with:binary
[45]
Darwin, sexual selection, and the brain - PNAS
Feb 15, 2021 · He had found that many species were sexually dimorphic, and often the more elaborately adorned sex was the male; these traits were quite varied ...
[46]
"Sexual Dimorphism for Size in Seven Nineteenth Century ...
An investigation of sexual dimorphism for size was conducted using data on 12 anthropometric measures from adults in seven nineteenth century local populations ...Missing: 19th | Show results with:19th
[47]
The Riddle of Sex: Biological Theories of Sexual Difference in the ...
Riddle propounded a metabolic theory of sex dating from the late-nineteenth century suggesting that metabolism lay at the heart of sexual difference.
[48]
Sex chromosome evolution: historical insights and future perspectives
May 3, 2017 · In 1959, a male-determining factor was discovered on the human Y [48]. This discovery was important because it was previously assumed that sex ...
[49]
Sex Determination in Humans | Embryo Project Encyclopedia
Jul 16, 2021 · After the discovery of inactivated X chromosomes in 1949, scientists began to determine an organism's biological sex by detecting whether dense ...
[50]
Genetics of Sexual Differentiation | GLOWM
The observation of dimorphic sex chromosomes in 1905 led to the idea that a gene on the Y chromosome was testis determining. In humans, this was not confirmed ...Genetics Of Sexual... · Gonadal Embryology · Genetics Of Testis...Missing: discoveries post-
[51]
Gene Action in the X-chromosome of the Mouse (Mus musculus L.)
Mary Lyon and the birth of X-inactivation research. Marnie E. Blewitt. Nature Reviews Genetics (2024). Unraveling the role of Xist in X chromosome inactivation ...
[52]
X-chromosome inactivation and escape - PMC - PubMed Central
X-chromosome inactivation, which was discovered by Mary Lyon in 1961 results in random silencing of one X chromosome in female mammals.
[53]
Mary Lyon and the hypothesis of random X chromosome inactivation
Mary Lyon's 1961 Nature paper, proposing random inactivation in early embryonic life of one of the two X chromosomes in the cells of mammalian females.
[54]
Sry: the master switch in mammalian sex determination | Development
Dec 1, 2010 · The human SRY gene was identified by searching for conserved sequences among translocated Y chromosomal DNA from four XX male patients (Sinclair ...Sry Expression And Its... · Mechanism Of Sry Action · Sox9: A Major Sry Target
[55]
Sry and the hesitant beginnings of male development - ScienceDirect
Feb 1, 2007 · The discovery of Sry in 1990 was expected to provide the key to unravelling the network of gene regulation underlying testis development.
[56]
"Genetic Evidence Equating SRY and the Testis-Determining Factor ...
Jan 10, 2014 · The study showed that the SRY gene causes testes development and encodes the TDF protein, and a mutation in SRY can cause female development.
[57]
Eleven years of sexual discovery - PMC - PubMed Central
This means that SRY is a relatively recent mammalian invention, appearing approximately 130 million years ago. Graves proposed that SRY arose when another SOX ...
[58]
Twenty-five years since the discovery of the human sex determining ...
Jul 21, 2015 · After the discovery of SRY, Professor Sinclair then went on to prove that SRY was, indeed, the human sex determining gene by finding XY female ...
[59]
SRY Gene - an overview | ScienceDirect Topics
SRY is a key transcription factor that induces the development of testes rather than ovaries by directing embryonic bipotential gonads.<|separator|>
[60]
Height and sexual dimorphism of stature among human societies
Jan 1, 1980 · This article explores the relationship between sexual dimorphism of stature and variables of marriage, diet, subsistence and environment.
[61]
Comparative data on the division of labor by sex
Abstract. Data on the distribution of economic activities between the sexes is presented. Tabulations suggest that preindustrial societies have a strong ...Missing: based | Show results with:based<|separator|>
[62]
A Note on the Division of Labor by Sex1 - Brown - 1970
Although sex division of labor is a universal, the contribution that women make to subsistence varies markedly from society to society.Missing: based | Show results with:based
[63]
[PDF] Cross-Cultural Analysis of the Behavior of Women and Men
Cross-Cultural Analysis of Behavior 2. Abstract. This article evaluates origin theories of sex differences in human behavior by reviewing cross-.
[64]
No strong evidence for universal gender differences in the ...
Within societies, gender is an important source of variation in behaviour, as division of labour between men and women is a universal feature of human societies ...
[65]
[PDF] How Sexually Dimorphic Are Human Mate Preferences?
The key theoretically pre- dicted patterns of sex differences in mate selection appear to be cross-culturally universal. These findings have been repli- cated ...
[66]
Sexual Dimorphism, Stature - Human Relations Area Files
Jan 1, 1982 · Sexual dimorphism in stature will be associated with variation in the sexual division of labor (27). Supported, 2. More. Cite; Related ...
[67]
Female Foragers Sometimes Hunt, Yet Gendered Divisions of Labor ...
While gender roles are certainly flexible, and prominent and well-studied cases of female hunting do exist, it is more often men who hunt. A new study (Anderson ...
[68]
[PDF] Female foragers sometimes hunt, yet gendered divisions of labor ...
May 7, 2024 · However, their analysis does not contradict the wide body of empirical evidence for gendered divisions of labor in foraging societies.
[69]
(PDF) The Evidence Against Hunter-gatherer Theory: The Evolution ...
The sexual division of labor among human foraging populations has typically been recognized as involving males as hunters and females as gatherers. Recent ...
[70]
The Myth of Man the Hunter: Women's contribution to the hunt ...
Jun 28, 2023 · Our hypothesis is that the majority (i.e., more than half) of hunter-gatherer communities do expect females to contribute to hunting strategies.
[71]
Women's contribution to the hunt across ethnographic contexts - PMC
Jun 28, 2023 · Our hypothesis is that the majority (i.e., more than half) of hunter-gatherer communities do expect females to contribute to hunting strategies.
[72]
Woman the Hunter? Female foragers sometimes hunt, yet gendered ...
Feb 27, 2024 · However, their analysis does not contradict the wide body of empirical evidence for gendered divisions of labor in foraging societies.
[73]
Recent Research Overstated How Much Women Hunt In Foraging ...
May 15, 2024 · Over the past few years, several studies have suggested that women hunted in many prehistoric hunter-gatherer cultures. Most prominently, a 2020 ...
[74]
[PDF] On the Origins of Gender Roles: Women and the Plough
We begin our analysis by first confirming that societies that traditionally used plough agriculture had lower female participation in agricultural activities.
[75]
[PDF] On the Origins of Gender Roles: Women and the Plough
We find that, consistent with existing hypotheses, the descendants of societies that traditionally practiced plough agriculture, today have less equal gender.
[76]
[PDF] On the Origins of Gender Roles: Women and the Plough
We test the hypothesis that traditional agricultural practices influenced the historical gender division of labor and the evolution of gender norms.<|control11|><|separator|>
[77]
Traditional farming practices and the evolution of gender norms ...
Jun 5, 2013 · In particular, traditional plough agriculture is associated with self-reported attitudes reflecting greater gender inequality, and with lower ...
[78]
Is gender primacy universal? - PNAS
Aug 19, 2024 · This study supports the idea that gender is a fundamental social category across societies by investigating its primacy in social perception.
[79]
New Research Reveals Insights into Gender Equality in Hunter ...
Nov 28, 2024 · These societies are well-known for having gender-egalitarian norms, which provide both men and women equal autonomy and decision-making power, ...
[80]
Hunter-Gatherer Societies Offer Insights Into Gender Equality
Dec 1, 2024 · "Our findings show that in these hunter-gatherer societies, both men and women contribute significantly to their households, resulting in a fair ...
[81]
On the Relationships Between the Grammatical Genders of ...
Mar 17, 2021 · When a noun refers to an animate object, its grammatical gender typically reflects the biological sex or gender identity of that object (Zubin ...
[82]
[PDF] Grammatical Gender and Biological Sex in Ancient Rome
The grammatical gender of inanimate objects, we are taught, is a con- venient linguistic convention, having no correspondence with any sort of imag- ined sexual ...
[83]
The Sex of Language: Jacob Grimm on Grammatical Gender
Aug 10, 2021 · By insisting not only on an original connection between grammatical gender and biological sex, but also that this connection is ...
[84]
Grammatical gender universalities underlying uniform mental ...
Oct 30, 2024 · This research reveals universal tendencies in grammatical gender affiliation of the analysed nouns in 32 two and three gender languages.
[85]
Coeducation (19th-21st centuries) | EHNE
Single-sex schools developed in Europe in the early modern period since boys and girls were expected to lead different lives and hence acquire different ...
[86]
In which countries do children attend single-sex schools?
Mar 29, 2021 · We find that single-sex schooling decreased in Australia and the Republic of Korea. The latter shifted to co-education schools in the 1980s.
[87]
[PDF] Copy of Promises and Pitfalls of Single-Sex Education: Final Report
Jul 24, 2025 · Historically, single-sex schooling was the predominant model; however, the modern educational landscape shifted dramatically toward coeducation ...<|separator|>
[88]
The Strange Evolution of Title IX | National Affairs
Both Title IX itself and the 1975 regulations clearly authorize schools to provide separate bathrooms, showers, housing, and sports teams for males and females.
[89]
U.S. Olympic Committee's New Transgender Athlete Ban Highlights ...
Aug 19, 2025 · The USOPC has banned transgender athletes from competing in women's sports, becoming the latest institution to align with a recent executive ...
[90]
Supreme Court judgment: summary and practical advice - Sex Matters
Apr 21, 2025 · The Supreme Court has clarified that “sex” in the Equality Act 2010 means biological sex, male or female. Policies should use this definition.
[91]
Gender Identity Policy Under the Biden Administration
May 2, 2022 · Male participation in contact sports with and against females increases females' risk of physical injury.[214] In practice, not limiting women's ...
[92]
Sex Redefined: The Idea of 2 Sexes Is Overly Simplistic
Feb 18, 2015 · The idea of 2 sexes is overly simplistic. Biologists now think there is a larger spectrum than just binary female and male.
[93]
The Inclusion of Sex and Gender Beyond the Binary in Toxicology
Assigned sex is the label given at birth by medical professionals based on an individual's chromosomes, hormone levels, sex organs, and secondary sex ...
[94]
Sex is a Biological Trait of Medical Significance
Sex is a dimorphic, innate trait defined in relation to an organism's biological role in reproduction.<|control11|><|separator|>
[95]
Understanding the Sex Binary - by Colin Wright - Reality's Last Stand
Aug 4, 2024 · When biologists claim that “sex is binary,” they mean something straightforward: there are only two sexes. This statement is true because an ...
[96]
Sex Differences in Human Brain Structure at Birth
Oct 17, 2024 · It is noteworthy that a meta-analysis [1] has previously reported 12% larger intracranial and 10.8% larger total brain volumes in males than ...
[97]
A meta-analysis of sex differences in human brain structure - PMC
This is the first meta-analysis of sex differences in the typical human brain. Regional sex differences overlap with areas implicated in psychiatric conditions.Missing: 2020-2025 | Show results with:2020-2025
[98]
Sex differences and age-related changes of large-scale brain ...
Jul 6, 2025 · The study explores how age and sex influence large-scale brain functional connectivity (FC). It finds that males typically exhibit stronger inter-network ...
[99]
Mapping Brain Growth and Sex Differences Across Prenatal to ...
Mar 17, 2025 · Additionally, sex differences in brain growth patterns were observed, with males showing greater volumetric increases with age compared with ...
[100]
Effects of Prenatal Testosterone Exposure on Sexually Dimorphic ...
Since perinatal testosterone (T) secreted by the developing testes masculinizes cortical and hippocampal structures and the behaviors regulated by these brain ...
[101]
Fetal Testosterone Influences Sexually Dimorphic Gray Matter in the ...
Jan 11, 2012 · We show that variation in fetal testosterone (FT) predicts later local gray matter volume of specific brain regions in a direction that is congruent with ...
[102]
Gene regulation by gonadal hormone receptors underlies brain sex ...
May 4, 2022 · Oestradiol establishes neural sex differences in many vertebrates and modulates mood, behaviour and energy balance in adulthood.
[103]
Sex Hormones and Gender Role Relate to Gray Matter Volumes in ...
Jun 17, 2019 · The present study investigates the relationship of circulating sex hormone levels and gender role to gray matter volumes in sexually dimorphic brain areas.
[104]
Sex beyond the genitalia: The human brain mosaic - PNAS
Joel (4, 5) has recently argued that the existence of sex/gender differences in the brain is not sufficient to conclude that human brains belong to two distinct ...
[105]
Mosaic Brains? A Methodological Critique of Joel Et Al.
Aug 7, 2025 · In their widely publicized paper, Joel et al. (1) make two empirical claims about sex differences in features of the human brain: (i) “…internal ...
[106]
Debunking the male-female brain mosaic - Wiring the Brain
Aug 28, 2017 · This is the claim made by psychologist Daphna Joel and colleagues, based mostly on a 2015 neuroimaging study in humans, but also some previous ...
[107]
Comparative neuroimaging of sex differences in human and mouse ...
Mar 15, 2024 · This study provides the first cross-species comparison of the effects of sex on human and mouse brain anatomy. Our findings suggest that sex ...<|separator|>
[108]
Transcriptomic sex differences in early human fetal brain development
Apr 25, 2025 · The influence of sex chromosomes and sex hormones on early human brain development is poorly understood.<|separator|>
[109]
Sex is binary, say majority of scientists polled - The Telegraph
Mar 2, 2024 · A survey of almost 200 scientists at British universities, conducted by The Telegraph and Censuswide, found 58 per cent of respondents think sex is binary.
[110]
Majority of scientists at UK universities agree sex is binary: poll
Mar 4, 2024 · A majority of British scientists in a new poll reported that they view sex as binary and believe that gender is fluid.
[111]
A poll of UK scientists shows most agree that sex is binary
Feb 15, 2025 · It strikes me that those who say that sex isn't binary, invoking other factors like hormones, chromosomes, genital configuration, and so on, ...
[112]
https://www.wsj.com/articles/a-biologist-explains-why-sex-is-binary-gender-male-female-intersex-medical-supreme-court-ketanji-brown-jackson-lia-thomas-3d22237e
[113]
Viewpoint: 'Utter nonsense'—A biologist's view of the ...
Jun 10, 2025 · Viewpoint: 'Utter nonsense'—A biologist's view of the administration's declaration defining biological sex. Ricki Lewis | June 10, 2025.
[114]
Three in 10 UK scientists believe sex isn't binary - UnHerd
Mar 4, 2024 · Almost three out of 10 British scientists have said in a poll that they don't believe sex is binary. Almost two-thirds believe that “gender” is fluid.Missing: 2023 2025
[115]
Neurobiology of gender identity and sexual orientation - PMC
The biological basis of gender identity cannot be modelled in animals and is best studied in people who identify with a gender that is different from the sex ...
[116]
Biological studies of transgender identity: A critical review
Jan 27, 2025 · In this review, we critically examine the biological literature which explores the etiology of transgender identity, including endocrinological, behavioral, ...
[117]
Gender dysphoria in twins: a register-based population study - Nature
Aug 4, 2022 · estimated heritability at 62%, while Sasaki et al. found a heritability of 41% for adolescent assigned females (aF) and 11% for adult aF, and no ...
[118]
Using twin data to examine heritable and intrauterine hormonal ...
Jul 1, 2025 · To date, heritability estimates for gender identity have come from eight published twin studies. Seven provided evidence suggesting a genetic ...
[119]
Biological origins of sexual orientation and gender identity
Multiple layers of evidence confirm that sexual orientation and gender identity are as biological, innate and immutable as the other traits conferred during ...
[120]
Brain Sex: Differences That Do Not Differentiate | Archives of Sexual ...
Oct 10, 2025 · A meta-analysis of sex differences in human brain structure. Neuroscience and Biobehavioral Reviews, 39(100), 34–50. https://doi.org/10.1016 ...
[121]
Sex versus gender associations with brain structure - ScienceDirect
We found that female sex, independent of continuum scores, was associated with larger proportion-adjusted volumes for the basal ganglia, hippocampus, and ...
[122]
“Precision Medicine” and the Failed Search for Binary Brain Sex ...
Apr 10, 2025 · Note that neither variable is binary and there is bidirectional influence between them. Sex characteristics influence gender identity, ...
[123]
False Assumptions Behind Youth Gender Transitions - SEGM
Dec 30, 2022 · A recent paper takes on 5 key faulty assumptions behind gender-affirming interventions for youth.
[124]
A Follow-Up Study of Boys With Gender Identity Disorder - PMC
Boys clinic-referred for gender identity concerns in childhood had a high rate of desistance and a high rate of a biphilic/androphilic sexual orientation. The ...
[125]
Gender Identity, Biological Sex, and Psychopathology: Back to Basics
Jan 4, 2025 · In these answers I clarify how I think about the relationship between gender identity and biological sex and why I resist seeing trans identity ...
[126]
Sex, gender and gender identity: a re-evaluation of the evidence
In this article we reappraise the phenomenology of gender identity, contrast 'treatments' for homosexuality with those for gender non-conformity.
[127]
Gender Dysphoria Statistics, Prevalence, Influencing Factors, and ...
Aug 30, 2024 · Gender dysphoria prevalence accounts for 0.005–0.014% of the population for biological males and 0.002–0.003% for biological females.Prevalence Of Gender... · Age And Gender Identity · Factors Influencing...
[128]
Gender Dysphoria Statistics in the United States
Dec 3, 2024 · In 2021, approximately 42,000 children and adolescents in the U.S. (aged 6 to 17) were diagnosed with gender dysphoria, marking a nearly ...
[129]
Epidemiology of gender dysphoria and gender incongruence in ...
Jan 24, 2025 · Results Between 2011 and 2021, incidence rates of recorded gender dysphoria/incongruence increased from 0.14 (95% CI 0.08 to 0.20) to 4.4 (95% ...
[130]
Likely 50-fold rise in prevalence of gender related distress from ...
Jan 24, 2025 · Analysis of the data showed that between 2011 and 2021, incidence rates of recorded gender dysphoria rose from 0.14 per 10,000 to 4.4 per 10,000 ...Missing: population | Show results with:population
[131]
Desistance Is Possible - Parents Of Desisters
In 11 longitudinal studies, on average 80% of children did not persist with a transgender identity into adulthood. The Detransition Rate is Unknown: Some people ...
[132]
The Final Cass Review and the NHS England Response - SEGM
Apr 11, 2024 · The Cass Report provides a scathing assessment of the gender-affirming approach in general, and the gender-clinic model of care, which ...
[133]
What does the scholarly research say about the effect of gender ...
Pooling data from numerous studies demonstrates a regret rate ranging from . 3 percent to 3.8 percent. Regrets are most likely to result from a lack of social ...
[134]
Accurate transition regret and detransition rates are unknown - SEGM
Sep 11, 2023 · Regret and detransition are examples of negative outcomes. Proponents of youth gender transition assert that rates of regret and detransition ...
[135]
Long-term follow-up of transsexual persons undergoing sex ...
Persons with transsexualism, after sex reassignment, have considerably higher risks for mortality, suicidal behaviour, and psychiatric morbidity than the ...
[136]
Americans' Complex Views on Gender Identity and Transgender ...
Jun 28, 2022 · Previously published findings from the survey show that 1.6% of U.S. adults are trans or nonbinary, and the share is higher among adults younger ...Missing: 2020-2025 | Show results with:2020-2025
[137]
LGBTQ+ Identification in U.S. Rises to 9.3% - Gallup News
Feb 20, 2025 · Overall, 85.7% say they are straight, 5.2% are bisexual, 2.0% are gay, 1.4% are lesbian and 1.3% are transgender. Just under 1% mention some ...
[138]
Gender & LGBTQ - Research and data from Pew Research Center
A new Pew Research Center survey finds that 1.6% of US adults are transgender or nonbinary – that is, their gender is different from the sex they were assigned ...
[139]
Young Americans are increasingly identifying as heterosexual again
Oct 15, 2025 · Specifically, there has been a decline of between 3 to 6 percent in the number of students identifying as non-binary in 2025, compared to 2023.
[140]
Gender identity, England and Wales: Census 2021
Jan 6, 2023 · A total of 45.4 million (93.5%) answered “Yes”, indicating that their gender identity was the same as their sex registered at birth.
[141]
Review of statistics on gender identity based on data collected as ...
Sep 12, 2024 · National vs local level estimates ONS has found in its research that it cannot say with certainty whether the census estimate that 0.54% of the ...Missing: rates | Show results with:rates
[142]
Flawed census question leads to inaccurate data on gender identity
Apr 30, 2024 · A new article published in the journal Sociology argues that data on gender identity from the 2021 Census of England and Wales is implausible.
[143]
Estimates and characteristics of LGBTI+ populations in Australia, 2022
Dec 19, 2024 · 29.3% are trans women, and; 32.7% are non-binary people. People aged 16–24 years are more likely than any other age group to be trans and gender ...
[144]
Analysis of non-binary sex responses | Australian Bureau of Statistics
Sep 27, 2022 · 2021 Census results · three in five indicated a gender identity using terms such as agender, demiboy, gender fluid, non-binary gender and trans ...
[145]
The Second Sex: Famous Quotes Explained | SparkNotes
“One is not born, but rather becomes, a woman.” This, the opening line of Book II, is de Beauvoir's most famous statement.
[146]
Becoming A Woman: Simone de Beauvoir on Female Embodiment
“One is not born, but rather becomes, a woman” Simone de Beauvoir. Generally for existentialists, one is not born anything: everything we are is the result ...
[147]
[PDF] Performative Acts and Gender Constitution
As a public action and performative act, gender is not a radical choice or project that reflects a merely individual choice, but neither is it imposed or ...
[148]
Judith Butler: Gender and Performativity - ReviseSociology
Feb 24, 2025 · Butler's Theory of Gender Performativity Butler argues that both sex and gender are socially, not biologically, determined. At the heart of her ...
[149]
Judith Butler: their philosophy of gender explained - The Conversation
Oct 19, 2022 · Butler argues that we reproduce gender not only through repeated ways of speaking, but also of doing. We dress in certain ways, do certain ...
[150]
Explanation of the Concept of Social Construction of Gender
Social constructivists propose that there is no inherent truth to gender; it is constructed by social expectations and gender performance. KEY POINTS. Social ...
[151]
Gender as Biological Fact vs Gender as Social Construction
The first view says that biological sex largely defines gender, the other that society or culture largely defines it. I will call this opposing pair of views ...
[152]
(PDF) The Social Construction of Gender - ResearchGate
May 13, 2023 · Social constructionists argue that gender is not sex. Rather, gender is an organizing principle of social orders that divides people into two major categories.<|separator|>
[153]
To explain biological sex, look to evolution - Nature
Jul 9, 2024 · Some organisms produce both male and female gametes, and others produce different gametes at distinct life stages or under various conditions.
[154]
A Biologist Explains Why Sex Is Binary - Manhattan Institute
Apr 9, 2023 · Commentary By Colin Wright. A Biologist Explains Why Sex Is Binary ... Are sex categories in humans empirically real, immutable and binary ...
[155]
The correlation between anisogamy and sexual selection intensity ...
Jul 12, 2024 · Darwin and Bateman suggested that precopulatory sexual selection is more intense on males than females, and that this difference is due to anisogamy.
[156]
Anisogamy and sex roles: a commentary | Evolution Letters
Oct 23, 2024 · Recent meta-analyses and theoretical models have helped to elucidate the processes that generate diverse sex roles.
[157]
Biology should not dispense with sexes - ScienceDirect
Apr 7, 2025 · We argue that dispensing with sexes would be a grave scientific error, depriving biology of one of its most powerful tools for explaining biological diversity.Missing: criterion | Show results with:criterion
[158]
Trans inmate jailed for Wakefield prison sex offences - BBC
Oct 11, 2018 · A transgender prisoner who sexually assaulted two inmates at a women's jail and had previously raped two other women has been given a life ...
[159]
The Scottish Gender Recognition Reform Bill - Policy Exchange
Jan 12, 2023 · This report demonstrates that the Scottish National Party's (SNP) Gender Recognition Reform Bill, which aims to change the law regulating legal sex change.
[160]
Lia Thomas Wins an NCAA Swimming Title - The New York Times
Mar 17, 2022 · Thomas's victory made her the first openly transgender woman to win an N.C.A.A. swimming title, a feat that came nearly three years after the ...
[161]
Sexual assaults in women's prison reignite debate over transgender ...
Sep 9, 2018 · A leading prison reformer has said prisoners who have committed violent offences against women should not be able to transfer to women's prisons.
[162]
Eleven transgender inmates sexually assaulted in male prisons last ...
May 21, 2020 · Last week, ministers revealed that out of 124 sexual assaults in five women's jails over the previous nine years, from 2010 to 2018, seven had ...
[163]
A Look At the Numbers and Times: No Denying Advantages of Lia ...
Apr 5, 2022 · In the 500 freestyle, Thomas' time of 4:33.24 from her NCAA-title swim handed her the fastest time in the nation by more than a second over ...Missing: impact | Show results with:impact
[164]
Lia Thomas controversy surrounds NCAA swimming championships
Mar 15, 2022 · Her time of 4 minutes, 34.06 seconds trailed Katie Ledecky's record by 10 seconds. Close enough for eyebrows to raise. Thomas was undefeated in ...
[165]
Safety and Privacy in Public Restrooms and Other Gendered Facilities
Feb 5, 2025 · Research consistently finds that transgender people report negative experiences like harassment and violence when accessing bathrooms.
[166]
Gender Recognition Reform (Scotland) Bill: equality impact ...
Mar 3, 2022 · As of May 2018, around 0.5% of the Scottish population (24,000 people) were estimated to be trans. The Scottish Public Health Network Report on ...
[167]
Prostate Cancer Test Is Missing Early Disease in Transgender Women
Jun 28, 2024 · Transgender women on hormone therapy tend to skew artificially low on prostate cancer screening tests, which may give false reassurance and delay diagnosis and ...
[168]
Assessing and Addressing Cardiovascular Health in People Who ...
Jul 8, 2021 · Conversely, women who are transgender had >2-fold increase in the prevalence of myocardial infarction compared with women who are cisgender but ...Life's Simple 7... · Additional Risk Factors And... · Vascular Health And Function
[169]
Pregnant Transgender Men at Risk for Depression and Lack of Care ...
Aug 15, 2019 · While some plan to become pregnant, the research suggests that unintended pregnancies occur in up to 30 percent of transgender men. According to ...
[170]
Breast cancer screening in transgender men
Jun 17, 2016 · Transgender men who have not undergone bilateral mastectomy, or who have only undergone breast reduction, should undergo screening according to current ...
[171]
Pregnancy in transgender men - PMC - NIH
Aug 23, 2021 · Transgender men with a uterus are at risk of unplanned pregnancy. Limited literature suggests similarly high rates of unplanned pregnancies in this population ...
[172]
We must not forget transgender patients' physiology if we are to ...
Mar 25, 2020 · Biological differences between the sexes mean that conflating sex and gender could have serious implications for prescribing.
[173]
Full article: The intersection of the laboratory and transgender care
A number of diagnostic pathology tests are provided to medical professionals with sex specific reference intervals (RIs) for interpretation, due to sex specific ...
[174]
Gender Dysphoria/Gender Incongruence Guideline Resources
Oct 25, 2024 · Gender-dysphoric/gender-incongruent persons should receive a safe and effective hormone regimen that will suppress the body's sex hormone ...
[175]
These states are narrowly defining who is 'female' and 'male' in law
May 3, 2023 · A "female" produces eggs and a "male" produces sperm. The bill also includes language that there are exactly two sexes. But research shows that ...
[176]
S.5356 - Defining Male and Female Act of 2024 118th Congress ...
Nov 20, 2024 · (8) Legal equality of the two sexes—male and female—does not imply that the sexes are identical to each other or are the same in every respect.
[177]
Three States Define Male and Female in New Laws
Apr 30, 2025 · The Utah, West Virginia, and Wyoming legislatures have enacted laws recognizing gender as solely binary—male and female—and unchangeable, ...
[178]
States Amend Definitions of Sex: Ohio, North Carolina, and More
Aug 27, 2025 · Utah: Enacted in 2024, Utah passed a law defining sex as biologically male or female, limiting the legal recognition of gender identity.
[179]
Defending Women From Gender Ideology Extremism And Restoring ...
Jan 20, 2025 · It is the policy of the United States to recognize two sexes, male and female. These sexes are not changeable and are grounded in fundamental ...
[180]
Transcending the Gender Binary under International Law
This article examines how legal recognition of gender identity and expression under international human rights law is needed to advance global health and human ...
[181]
X Gender Marker Available on U.S. Passports Starting April 11
Mar 31, 2022 · Starting on April 11, US citizens will be able to select an X as their gender marker on their US passport application, and the option will become available for ...
[182]
Why States Must Define Sex Precisely | The Heritage Foundation
Mar 31, 2023 · Gender activists are now working to redefine sex in federal laws and regulations, such as Title IX, to include “gender identity.”
[183]
Legal Rulings on Sports Participation Rights of Transgender Athletes
Sep 29, 2020 · Although the Supreme Court's ruling in the Bostock case, a consolidation of three lawsuits alleging discrimination against LGBTQ persons in the ...
[184]
Evidence on sex differences in sports performance
The profound sex differences in sports performance are primarily attributable to the direct and indirect effects of sex-steroid hormones and provide a ...
[185]
Effect of gender affirming hormones on athletic performance in ...
In this study, we confirmed that use of gender affirming hormones are associated with changes in athletic performance and demonstrated that the pretreatment ...
[186]
Strength, power and aerobic capacity of transgender athletes
This research compares laboratory measures of strength, power and V̇O2max of transgender male and female athletes to their cisgender counterparts. Transgender ...
[187]
Two new scientific reviews agree that transwomen athletes retain ...
Mar 7, 2021 · The two studies arrive at the same conclusion: male athletes suppressing testosterone in order to transition lose little in the way of muscle mass and strength.
[188]
Sex differences and athletic performance. Where do trans ... - NIH
Oct 27, 2023 · This review seeks to offer considerations for whether trans individuals should be excluded from sports and athletics, and how future research should proceed.
[189]
Transwoman Elite Athletes: Their Extra Percentage Relative ... - MDPI
This descriptive critical review discusses the inherent male physiological advantages that lead to superior athletic performance.2.2. Testosterone And Muscle... · 2.4. Testosterone And The... · 3.3. Estrogen Therapy Does...Missing: persist | Show results with:persist
[190]
NCAA announces transgender student-athlete participation policy ...
Feb 6, 2025 · The new policy limits competition in women's sports to student-athletes assigned female at birth only. The policy permits student-athletes ...
[191]
Keeping Men Out of Women's Sports - The White House
Feb 5, 2025 · . Many sport-specific governing bodies have no official position or requirements regarding trans-identifying athletes. Others allow men to ...
[192]
What's at Stake as the Supreme Court Takes Up Transgender Sports ...
Sep 29, 2025 · Now, the Supreme Court will hear our challenge against a state law that categorically bans transgender students from girl's teams. Politicians ...Missing: binary | Show results with:binary
[193]
Gender and School Sports: Federal Action and Legal Challenges to ...
Aug 13, 2025 · On February 6, 2025, the NCAA's Transgender Student-Athlete Participation Policy (NCAA Policy) was updated in response to President Trump's EO ...
[194]
Trans Inclusion & Women's Sport
While many sports currently try to negate male physiological advantages through transgender inclusion policies based on testosterone suppression and measurement ...Missing: persist | Show results with:persist<|separator|>
[195]
How pop culture embraced sexuality 'without labels' - BBC
Jun 19, 2019 · More and more people are refusing to define themselves as either gay or straight – and from pop music to sitcoms, such fluidity is becoming ...
[196]
Trans Lives & Positive Visibility - HRC - Human Rights Campaign
Visibility of trans and non-binary people has increased in recent years with more coverage of stories about the community by the news and media.Missing: fluid timeline
[197]
The Rise of Transgender and Gender Diverse Representation in the ...
The current study interviewed 27 TGD individuals. These interviews exposed how participants view the rise of TGD media representation.Missing: Hollywood | Show results with:Hollywood<|control11|><|separator|>
[198]
Researchers explain social media's role in rapidly shifting social ...
May 29, 2024 · A new paper by UC Santa Cruz psychologists describes how social media has supported an explosion of diversity in gender and sexuality in America ...
[199]
What's Behind the Rapid Rise in LGBTQ Identity?
Mar 6, 2025 · Another possible explanation for why women have experienced the most dramatic growth in LGBTQ identity is social media. Young women are ...<|separator|>
[200]
Social media use and experiences among transgender and gender ...
Sep 4, 2023 · The present study aims at assessing how and for which purposes TGD adolescents use the internet and social media and how often they experience support compared ...
[201]
https://www.foxnews.com/health/number-young-adults-identifying-transgender-plunges-nearly-half-two-years
[202]
Media Portrayals of Trans and Gender Diverse People
Feb 27, 2024 · The present study investigated how media representations of TGD people in news headlines varied across three European countries with different levels of legal ...