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PMC

PubMed Central (PMC) is a free digital repository offering public access to the full-text of millions of peer-reviewed journal articles in and the life sciences. Launched in 2000 by the (NCBI) within the U.S. National Library of Medicine (NLM), a component of the (NIH), PMC archives over 10 million articles spanning from the late 1700s to the present, including primary research, reviews, and author manuscripts from thousands of participating journals. Its core mandate is to ensure permanent and of this literature to advance scientific inquiry, clinical practice, and policy-making, with content stored in standardized XML format for interoperability and bulk data retrieval. PMC operates primarily on an open-access basis, allowing immediate free reading and downloading of most articles, though some publishers enforce temporary embargoes before full availability; participation requires journals or funders to meet NLM criteria, such as consistent and compliance, fostering global collaborations while retaining protections for . Key achievements include democratizing access to high-volume scientific output—facilitating , systematic reviews, and evidence synthesis—and supporting mandates like the NIH Public Access Policy, which requires deposit of funded research to promote and . Nonetheless, PMC has drawn scrutiny for vulnerabilities in journal selection processes that have enabled leakage of low-quality or predatory publications, potentially diluting the repository's reliability amid academia's broader challenges and selective reporting tendencies. These issues underscore the tension between expansive and rigorous quality control in archiving literature prone to institutional biases favoring novel or positive findings over results.

Military and Defense

Private Military Company

A (PMC), also known as a private military and security company (PMSC), is a for-profit entity that offers specialized services including armed security, combat support, , , and protection to governments, corporations, or other clients in conflict or high-risk environments. These firms typically employ former to deliver capabilities such as convoy protection, base security, and advisory roles, operating under contractual arrangements that emphasize operational efficiency over traditional state hierarchies. PMCs differ from mercenaries by functioning as structured corporations accountable to contractual obligations and legal frameworks, rather than individual fighters for hire. PMCs proliferated after the Cold War's end in 1991, as states downsized and outsourced non-core functions amid reduced global tensions and surplus equipment availability. Their usage peaked during U.S.-led operations in and , where by fiscal year 2007, the Department of Defense (DOD), State Department, and USAID relied on tens of thousands of contractors for support roles, with DOD alone reporting approximately 104,000 contractor personnel in by mid-2008, often outnumbering uniformed troops in and tasks. These contractors handled critical functions like and personal protection for diplomats, enabling the U.S. to focus assets on primary objectives while minimizing exposure of active-duty forces to routine risks. Operationally, PMCs have demonstrated value through rapid deployment and specialized expertise drawn from ex-servicemen, contributing to stabilization in under-resourced theaters where national armies faced capacity gaps. Government analyses, including those from the (), highlight efficiencies in contracting for services like maintenance and transport, where private provision has allowed scalable responses without expanding permanent military footprints. For instance, in , contractors supported reconstruction and sustainment efforts, with data indicating they performed a substantial share of non-combat by 2007. Criticisms of PMCs center on challenges in overseas operations, exemplified by the , 2007, Nisour Square incident in , where guards fired on civilians, killing 17 and injuring others, prompting investigations into excessive force. The U.S. responded with the Military Extraterritorial Jurisdiction Act () of 2000, which extends federal criminal jurisdiction to contractors accompanying U.S. forces abroad, facilitating prosecutions such as the 2014 convictions of involved personnel (later partially pardoned in 2020). While isolated misconduct has fueled debate, empirical oversight improvements post-2007, including enhanced and State Department monitoring, have aimed to align PMC conduct with military standards through contract clauses and reporting.

Biomedical and Scientific Publishing

PubMed Central

(PMC) is a free full-text digital archive of biomedical and life sciences journal literature, developed and maintained by the (NCBI) at the U.S. (NLM), a component of the (NIH). Launched publicly in February 2000, PMC serves as a centralized repository for peer-reviewed articles, enabling unrestricted public access to scholarly content without subscription barriers. It accepts deposits from publishers, scholarly societies, and authors, with content spanning from historical journals dating back to 1809 to contemporary publications. As of 2025, PMC archives over 11.4 million full-text articles from more than 3,000 participating journals. A key driver of PMC's growth has been the NIH Public Access Policy, enacted in April 2008, which mandates that peer-reviewed manuscripts arising from NIH-funded research be submitted to PMC or its processing system (NIH Manuscript Submission System) no later than 90 days after , with availability typically after a 12-month embargo to respect publisher agreements. This policy, affecting all applicable publications accepted on or after April 7, 2008, has compelled deposits of final peer-reviewed versions, fostering broader dissemination of taxpayer-supported research while preserving incentives for commercial publishing through delayed . Compliance relies on authors or publishers uploading manuscripts, which undergo technical processing and quality checks before integration into PMC's searchable database, linked to citations for enhanced discoverability. PMC has demonstrably accelerated scientific progress by increasing article visibility and usage; empirical analyses indicate that open-access articles in PMC receive substantially higher citation counts compared to non-open-access counterparts, with studies reporting independent associations of 20-50% elevated citations after controlling for factors like journal impact and publication year, attributable to reduced access barriers enabling wider readership. This citation premium supports causal claims of enhanced knowledge diffusion, as evidenced by higher page views, downloads, and attention scores for PMC-hosted content. However, trade-offs include revenue pressures on traditional publishers, prompting open-access models where authors pay processing charges, and occasional dilution risks from expedited deposits potentially including preprints or less rigorously vetted material, though PMC mitigates this by requiring linkage to peer-reviewed sources and excluding non-journal content like book reviews from indexing. Criticisms of PMC center on administrative burdens for authors navigating , such as manuscript formatting and embargo tracking, which can delay workflows without proportional enforcement benefits, and concerns over inadvertent inclusion of predatory or low-quality journals via lax initial screening, despite NLM's ongoing efforts to delist unreliable titles based on criteria. While PMC's linkage upholds baseline rigor, rapid mandate-driven deposits have drawn scrutiny for potentially prioritizing volume over selective curation, leading to isolated instances of entering the archive before remediation; nonetheless, its overall credibility stems from transparent policies and empirical utility in global research access.

Healthcare Policy and Organizations

Personalized Medicine Coalition

The (PMC) is a nonprofit dedicated to promoting the understanding, development, and adoption of approaches that tailor treatments to individual patients based on genetic, molecular, and environmental factors. Established in 2004 by an initial group of approximately 20 institutions from pharmaceuticals, , diagnostics, academia, and , the PMC has expanded to include over 120 members representing diverse stakeholders in the healthcare . Its core activities involve educating policymakers, advancing regulatory frameworks supportive of biomarker-driven therapies, and fostering research into technologies such as gene editing and CAR-T cell treatments. The PMC's objectives center on shifting healthcare from one-size-fits-all models to evidence-based, individualized strategies, emphasizing the integration of diagnostics with therapeutics to improve efficacy and reduce adverse effects. Through , it pushes for reforms like streamlined FDA approvals for companion diagnostics and increased funding for research. A key focus is on empirical validation, as seen in its annual reports tracking FDA progress; for instance, in 2024, the FDA approved 18 new personalized medicines tied to specific biomarkers, comprising 38% of all novel therapeutic molecular entities. These approvals include advancements in , where approaches have demonstrated longer overall survival in late-stage patients receiving targeted therapies matched to tumor profiles compared to non-targeted options. The coalition has influenced policy milestones, such as FDA initiatives for liquid biopsy tests and expanded indications for biomarker-guided drugs, by providing data-driven analyses to regulators and lawmakers. In clinical settings, personalized strategies have yielded improved and overall outcomes in cases, with analyses showing potential survival extensions without proportional cost escalations in select cohorts. However, critics highlight limitations, including the high upfront costs of therapies—often exceeding $400,000 per patient for advanced treatments like CAR-T— which can restrict access and yield net monetary benefits that are zero or negative when weighing health gains against expenditures. Additionally, some argue that genomic hype overlooks variable efficacy across populations, as not all patients respond uniformly, underscoring the need for rigorous, individualized validation over broad generalizations. Despite these challenges, the PMC maintains that causal targeting of molecular drivers outperforms population-averaged dosing in empirically supported scenarios, prioritizing data from controlled trials over unsubstantiated enthusiasm.

Computing and Technology

Planet Minecraft

Planet Minecraft is an independent online platform dedicated to user-generated content for the video game Minecraft, launched on November 8, 2010, by developer Cyprezz to facilitate sharing of custom creations amid the game's rising popularity. The site emerged during Minecraft's early beta phase, providing a centralized hub for players to upload, download, and discuss modifications without any official endorsement from or its subsequent owner, , which acquired Mojang in September 2014. By enabling community-driven customization, Planet Minecraft has supported the proliferation of non-official extensions to the base game, independent of corporate updates. Key features include repositories for skins, mods, adventure maps, multiplayer servers, texture packs, and data packs, allowing users to browse millions of submissions categorized by type and popularity. As of recent data, the platform hosts over 3.3 million shared creations and counts more than 5.2 million registered members, with tools for forums, contests, and analytics to track engagement and downloads. These elements promote iterative feedback loops, where creators refine projects based on peer reviews and usage metrics, contributing to the site's role as a de facto archive for Minecraft modding history. The platform's growth parallels Minecraft's expansion, with empirical increases in user submissions correlating to major game releases, such as the 1.0 full version in and subsequent editions like . By fostering decentralized innovation—evident in sustained download volumes and active forums—Planet Minecraft has extended the game's ecosystem longevity, enabling players to adapt content across versions without relying on proprietary tools. This community autonomy has proven resilient, as evidenced by ongoing events like content jams that generate thousands of entries annually, despite shifts in official development priorities post-acquisition.

Portable Media Center

The Portable Media Center (PMC) was a software platform developed by Microsoft for portable media players capable of handling audio, images, and video content synchronized via Windows Media Player. Announced as "Media2Go" at the 2003 Consumer Electronics Show on January 9, 2003, it was officially renamed Portable Media Center in October 2003 and built on Windows Mobile software to enable seamless integration with PCs running Windows XP or later. The platform aimed to create an ecosystem for full-featured portable devices that could store and playback media libraries transferred from desktops, positioning it as an early competitor to emerging devices like Apple's iPod by emphasizing video and photo support alongside music. Compatible devices, released starting in 2004, included models from manufacturers such as Creative (e.g., Portable Media Center with 20 GB or 40 GB hard drives), iRiver (e.g., PMC120 with 20 GB storage), (e.g., Gigabeat series), , , and . These devices typically featured color LCD screens, hard disk storage capacities of 20 GB to 60 GB (holding up to 80 hours of video or 600 hours of music at standard bitrates), and battery life supporting 7-22 hours of playback depending on usage. Technical specifications mandated support for and WMA audio (including protected, lossless, and voice variants), images, and WMV video (versions 7-9) at resolutions up to 320x240 pixels, 30 frames per second, and bitrates to 800 Kbps, with content transfer optimized via 10's Auto Sync feature. Microsoft discontinued licensing the PMC platform in 2007, effectively ending new device development after limited market adoption. The platform's reliance on proprietary formats like WMA and WMV, coupled with shorter battery life and bulkier designs compared to rivals, hindered competitiveness against the iPod's dominance, which captured over 70% of the portable player market by 2005 through simpler MP3/AAC support and a closed ecosystem. While PMC devices prefigured portable video playback and library syncing central to later smartphones and streaming services, their proprietary constraints and the rise of multifunctional mobile phones shifted industry standards toward more versatile, open-compatible hardware by the late 2000s.

PMC-Sierra

, Inc. was a fabless company headquartered in , specializing in high-performance connectivity solutions for , communications, and . Founded in 1995 through the evolution of earlier entities including investments from Sierra Semiconductor (established 1984), the company developed integrated circuits that enabled efficient data transfer in enterprise and carrier networks. Its products targeted applications requiring high-speed serial interfaces, supporting the growth of by providing chips for optical transport, Ethernet aggregation, and interconnects. Key offerings included serializer/deserializer (SerDes) devices such as the OctalPHY and QuadPHY families, which facilitated multi-gigabit Ethernet and links with integrated features like auto-negotiation and low-power operation for metro and deployments. also produced RAID-on-Chip (RoC) controllers like the SmartROC series for and NVMe storage, delivering enhanced IOPS and throughput in PCIe-based systems, and processors for packet and edge to handle 10G+ demands. These components contributed to efficiency by reducing latency and power consumption in high-density environments, with from deployments showing doubled performance metrics in storage subsystems compared to prior generations. In November 2015, Microsemi Corporation announced its acquisition of for $2.5 billion, a deal completed on January 15, 2016, after outbidding competitors like . , in turn, was acquired by in 2018, integrating PMC-Sierra's portfolio into broader offerings for data centers and optical networks. This consolidation preserved the technology's role in enabling scalable bandwidth expansions but diminished PMC-Sierra's independent market presence, with products rebranded under Microchip for continued use in NVMe controllers and OTN/DWDM systems.

Project and Business Management

Project Management Committee

A Project Management Committee (PMC) functions as the primary governing and decision-making body for individual top-level projects within open-source software ecosystems, such as the (ASF), where it holds ultimate authority over technical direction and operations. Established as a core element of ASF since the foundation's maturation in the early 2000s, the PMC comprises elected or appointed committers who collectively oversee project health, including the approval of development roadmaps that outline strategic priorities, feature sets, and release schedules. This structure ensures that project evolution aligns with -contributed goals rather than changes, with decisions typically reached through consensus-driven voting mechanisms among members. The PMC's responsibilities extend to resource stewardship, such as nominating and voting on new committers—who gain write access to project repositories—and allocating maintainer roles for subcomponents, thereby directing toward high-impact areas. In practice, PMCs conduct regular reviews of proposals for new features or architectural shifts, rejecting those that deviate from the project's foundational to maintain focus. For instance, in ASF projects like , the PMC has enforced disciplined evolution since the early 2000s, integrating modular enhancements while vetoing expansive rewrites that could fragment user bases. Similar models appear in other open-source initiatives, such as the GeoTools project, where the PMC sets overarching direction and resolves irreconcilable contributor disputes. These committees prioritize merit-based participation, requiring demonstrated contributions for membership, which fosters accountability without centralized top-down control. Empirical observations from long-lived governed projects indicate that PMC oversight correlates with mitigated risks of uncontrolled , as formalized processes compel and justification of changes, reducing instances of unapproved additions that inflate timelines. Case analyses of ASF projects highlight how such bodies sustain viability over decades—evident in the ASF's of over 300 active projects since 1999—by institutionalizing gates against divergent requests, though quantitative metrics on containment vary by project maturity and external pressures. Critics note potential bottlenecks in models, yet proponents attribute enduring success in tech consortia to this distributed authority, which decentralizes power while anchoring decisions to verifiable input.

Project Management and Control

Project Management and Control (PMC) refers to the set of processes, techniques, and tools used to monitor project performance, measure variances from , and implement corrective actions to ensure successful delivery within defined constraints of , time, , and . Unlike structures focused on oversight committees, PMC emphasizes operational execution through data-driven monitoring, such as tracking progress against baselines and adjusting resources dynamically to mitigate deviations. This approach integrates to provide objective insights into project health, enabling managers to forecast outcomes and respond proactively. Core techniques include (EVM), which combines planned value, earned value, and actual cost to calculate metrics like schedule variance (SV = EV - PV) and cost performance index (CPI = EV / AC), allowing for early detection of overruns. Risk tracking complements EVM by systematically identifying, assessing, and monitoring uncertainties through tools like risk registers and probabilistic modeling, often integrated to enhance predictive accuracy. These methods were formalized in the (PMBOK) Guide, with foundational standards emerging in the 1980s; the initial PMBOK document was released in 1987 based on practitioner consensus, evolving through subsequent editions to incorporate iterative refinements like agile hybrids by the seventh edition in 2021. PMC relies on specialized software for and , including Gantt charts to depict task dependencies, timelines, and critical paths, alongside dashboards for key performance indicators (KPIs) such as schedule adherence rates and resource utilization percentages. By 2025, AI-enhanced platforms like those incorporating for have become prevalent, offering real-time adjustments via automated forecasting— for instance, predictive algorithms that simulate delay impacts and recommend resource reallocations, reducing manual intervention in volatile environments. Empirical evidence from the () indicates that rigorous PMC practices causally contribute to reduced overruns, with organizations employing mature EVM systems achieving up to 20% savings on project costs and similar improvements in schedule efficiency through better variance control. However, in agile contexts, traditional PMC elements like rigid reporting can foster , imposing excessive documentation and ceremonies that undermine iterative flexibility and team , as observed in case studies of implementations where plan-driven controls clashed with adaptive workflows.

Charitable and Fundraising Organizations

Pan-Mass Challenge

The Pan-Mass Challenge (PMC) is an annual bicycle fundraising event founded in 1980 by Billy Starr to benefit and patient care at the Dana-Farber Cancer Institute via its affiliate. Participants engage in pledge-based to support the institute's programs, with the event evolving into the nation's largest single athletic fundraiser. As of 2024, the PMC has cumulatively raised $1.047 billion, including a record $75 million that year, accounting for 66% of the 's annual revenue. The PMC consists of multi-route, fully supported bike rides primarily held over two days in early across , originating from Sturbridge and concluding in Provincetown, with options for one- or two-day participation. Routes vary from 25 to 192 miles to accommodate different fitness levels, drawing over 6,000 riders and 270,000 donors annually. A defining feature is the allocation of 100% of rider-raised funds directly to Dana-Farber, enabled by a volunteer-driven operational model that covers event costs through separate sponsorships, ensuring minimal overhead deduction from pledges. PMC contributions have empirically advanced , notably supporting Dana-Farber's identification of the protein's mechanism in suppressing immune responses to tumors, which informed the development of PD-1/ inhibitor drugs central to modern protocols. These funds have enabled clinical trials and basic science yielding tangible outcomes, such as enhanced treatment responsiveness in resistant cancers. To expand accessibility, the event introduced PMC Unpaved in recent years—a gravel-specific variant with 30- and 50-mile routes through western Massachusetts's —culminating in a 2025 edition on October 4 that raised $1.2 million toward the prior year's total.

Arts and Crafts

Precious Metal Clay

Clay (PMC) is a sculptable material composed of microscopic particles of , primarily silver or , suspended in an and water to form a pliable, clay-like consistency suitable for crafting jewelry and small sculptures. The holds the metal particles together during manipulation, allowing shapes to be formed by hand, tools, or molds without requiring traditional techniques like or . Upon drying and firing, the burns away, leaving the sintered metal particles fused into a solid, durable object, typically with 8-30% shrinkage depending on the formula and firing conditions. Developed in during the early 1990s by metallurgist Masaki Morikawa at Corporation, PMC originated from innovations in refining precious metals for , adapting fine metal powders into an artistic medium. The company secured a for the on July 12, 1994, and launched it commercially that year, initially in before expanding globally. held the PMC and produced variants like PMC+, PMC3, and formulations, though it ceased manufacturing in March 2023 amid shifts in production priorities. The fabrication process involves modeling the moist clay into desired forms, drying it to remove water (often aided by air or low heat), and then kiln-firing at temperatures around 900°C (1650°F) for 1-2 hours to achieve full , though torch or firing suits smaller pieces. This method bypasses the labor-intensive process, enabling intricate, hollow, or textured designs that would be challenging or costly with solid metal stock. Post-firing, pieces can be polished, hallmarked, or set with stones, yielding results comparable to wrought precious metals in purity and strength. PMC has facilitated artisan jewelry production by democratizing access to fabrication for hobbyists and small-scale creators, reducing reliance on foundries and specialized equipment while supporting DIY crafts through accessible kits and classes. Its adoption grew in the late via U.S. distributors like , which introduced it to Western markets in 1996, fostering a niche for custom rings, pendants, and earrings. However, material costs exceed equivalent pure metal weights—such as $25-40 for 20 grams of silver PMC versus lower scrap silver prices—due to the and processing, though savings accrue from minimized and labor compared to traditional methods.

Government and Municipal Administration

Pune Municipal Corporation

The (PMC) is the civic administrative body responsible for urban governance in , , . Established on 15 February 1950 under the Bombay Provincial Municipal Corporations Act, 1949, it manages essential services for a population exceeding 3 million residents across an area of approximately 331 square kilometers as of recent expansions. Core functions include distribution, road maintenance and , solid through door-to-door collection and operations, , services via dispensaries, and enforcement. The executive authority vests in a , an officer, supported by elected corporators numbering 162 following the latest ward reconfiguration. PMC's jurisdiction has expanded significantly to accommodate Pune's rapid , incorporating 11 peripheral villages in adding 80.7 square kilometers and 278,000 residents, followed by 23 villages on 30 June 2021, including areas like Hinjewadi and Bavdhan, which increased the administrative footprint by over 100 square kilometers. These mergers, driven by suburban population surges from and IT sector , have strained , with merged zones facing persistent issues in —such as irregular supply and shortages—and accumulation due to inadequate collection capacity amid rising demand from an estimated annual influx of 180,000 migrants. Road networks in these areas often suffer from potholes and , exacerbating commute times, while overall pressures have led to calls for enhanced funding and separate civic entities in high-growth suburbs like Chakan. Under India's , PMC has implemented projects totaling ₹3,333 by mid-2025, including integrated command centers for grievance redressal, river rejuvenation efforts, and tech-enabled citizen engagement via the "" app, which earned the IEEE Smart Cities Award in 2024 for improving service responsiveness in legacy urban areas. Achievements encompass over 200 upgraded parks with and expansions, such as infrastructure enhancements recognized by for Transportation and Development Policy in 2020. However, implementation gaps persist, with criticisms centered on procurement irregularities in schemes like the 24x7 pilot, prompting demands for and Auditor General () scrutiny of data manipulation and fund utilization, though comprehensive audits have highlighted broader civic mismanagement rather than systemic unique to PMC. These efforts reflect ongoing tensions between growth imperatives and resource constraints in a projected to reach 7.7 million residents by 2030.

Other Municipal Corporations

The (PMC), established on August 15, 1952, under the Patna Municipal Corporation Act, 1951, serves as the primary civic body governing , the capital of , . It oversees essential urban services including , , solid , road construction and maintenance, and initiatives, operating across 96 wards with a population exceeding 2 million residents as of recent censuses. Like other municipal corporations worldwide, entities abbreviated as PMC typically handle core functions such as levying property taxes and user fees for revenue generation, enforcing and land-use regulations to manage urban growth, and implementing measures including and drives, with authority derived from national or legislation that delegates powers from higher governments. Variations occur by ; for example, in systems like India's, PMCs coordinate with pollution boards for environmental compliance, while in unitary systems, they may integrate more directly with national standards. Empirical analyses of municipal reforms highlight a trend toward privatizing select services to enhance , particularly in , distribution, and , where private provision has demonstrated cost reductions of 20-30% in comparable cases without compromising service quality, though outcomes depend on competitive bidding and oversight mechanisms. Such shifts address fiscal pressures from , as evidenced by studies across multiple countries showing sustained savings from contracted-out operations when transaction costs are minimized.

Aviation and Engineering

Power Management Controller

A Power Management Controller (PMC) is an electronic system or computer integrated into engines and electrical architectures to regulate power output, monitor electrical parameters such as voltage and current, and ensure stable operation across flight phases. In , PMCs command engines to deliver pilot-requested levels while automatically adjusting for conditions like climb, where they maintain optimal power settings to prevent overloads or inefficiencies. For instance, in , the PMC operates continuously as the primary engine power management unit, coordinating fuel flow and ignition to sustain rated power during transitions. Core functions of aviation PMCs include real-time fault detection through parameter monitoring, power optimization to minimize waste, and reconfiguration in response to anomalies, such as load shedding in more electric aircraft architectures. These controllers integrate with full authority digital engine controls (FADEC) to predict and mitigate failures via prognostics and health management (PHM) algorithms, enabling early detection of degrading components like generators or converters. In hybrid or electric propulsion systems, PMCs manage multi-source power flows, prioritizing critical loads and isolating faults to maintain redundancy. PMCs qualify as safety-critical hardware under RTCA standards, which mandate rigorous design assurance processes—including verification, traceability, and testing—for airborne electronic components since the standard's release in 2000. Compliance ensures deterministic behavior and , with levels aligned to Design Assurance Levels (DAL) A or B for controls, reducing risks of power loss events. In broader vehicle applications, analogous Power Management Integrated Circuits (PMICs) consolidate voltage regulators, battery chargers, and sequencing logic into single chips for efficient distribution in automotive and heavy-duty systems. Deployment of advanced PMCs has enhanced aircraft reliability by facilitating and automated fault isolation, contributing to lower in-flight power system incidents as reported in PHM implementations for . Empirical data from electrified tests show improved accuracy, minimizing through proactive over traditional reactive approaches.

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