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Transhuman

Transhumanism is a philosophical movement asserting that human beings may and should employ emerging technologies to overcome inherent biological constraints, thereby enhancing physical, intellectual, and psychological capacities to evolve toward a posthuman condition. The term was coined by biologist Julian Huxley in 1957, who envisioned humanity directing its own evolution through scientific means to realize greater potential beyond current limitations. Pioneered in the mid-20th century amid advances in genetics and computing, transhumanism gained organizational form in the late 20th century through figures such as Fereidoun M. Esfandiary (FM-2030), who emphasized proactive human transformation, and Max More, founder of the Extropy Institute, which promoted principles like boundless expansion and self-transformation via rational application of technology. Key proposed enhancements include genetic engineering, cybernetic implants, mind uploading, and artificial intelligence integration, with proponents arguing these could eradicate aging, disease, and cognitive bounds, fostering indefinite lifespans and superintelligence. Despite its optimistic vision grounded in empirical progress in and , elicits controversy over feasibility, equity, and existential risks; critics highlight potential exacerbation of social inequalities through access disparities to enhancements, unintended consequences like loss of human authenticity, and hazards from uncontrolled technologies such as artificial . Organizations like Humanity+ continue to advocate for ethical development of these technologies, balancing innovation with safeguards against dystopian outcomes.

Definition and Principles

Core Concepts and Goals

Transhumanism encompasses philosophies that advocate the use of scientific and technological means to radically extend human capabilities and transcend biological limitations, guiding humanity toward a future characterized by , , and adaptability. This approach rejects static views of , emphasizing instead the potential for self-directed through rational interventions in fields such as , , and . Central goals include achieving indefinite healthy lifespans by overcoming aging and disease, expanding cognitive faculties to enable superior problem-solving and creativity, and realizing morphological freedom—the autonomy to modify one's physical form, sensory experiences, and mental processes according to individual preferences. Proponents envision these advancements alleviating involuntary suffering, broadening mental horizons, and fostering diverse modes of existence beyond current human constraints, while prioritizing the well-being of all sentient beings, including future artificial intelligences. Underlying principles stress dynamic about technological , perpetual self-transformation, and the intelligent application of to challenge limits like and , within frameworks that promote , open , and spontaneous . , a prominent , outlines boundless of and , rejecting taboos against altering and advocating pragmatic to actualize these aims.

Philosophical Underpinnings

Transhumanism draws its philosophical foundations from evolutionary humanism, as articulated by biologist Julian Huxley, who coined the term in his 1957 essay "Transhumanism." Huxley envisioned humanity transcending its current biological constraints through deliberate scientific and technological intervention, describing it as "man remaining man, but transcending himself, by realizing new possibilities of and for his human nature." This perspective positions humans as active agents in their own evolution, moving beyond passive natural selection to achieve enhanced forms, such as a "Homo superior," via applied science rather than reliance on undirected processes. Earlier roots trace to , exemplified by Pico della Mirandola's 1486 Oration on the of , which emphasized human self-determination: individuals could "fashion yourself in the form you may prefer" through intellect and will. Enlightenment thinkers further developed this into rational humanism, with Bacon's 1620 Novum Organum advocating empirical for mastery over and Marquis de Condorcet's 1795 Sketch for a Historical Picture of the Progress of the Mind forecasting indefinite progress through medical and technological advances. These ideas reject supernatural or fatalistic constraints, prioritizing critical reason, , and —the in ongoing human improvement. In its modern form, transhumanist philosophy crystallized through Extropianism, formulated by Max More in the 1990 Principles of Extropy, which promote perpetual progress, self-transformation, practical optimism, intelligent technology use, open society, self-direction, and rational thinking. Unlike traditional humanism, which focuses on cultural and ethical refinement within biological limits, transhumanism extends to radical morphological freedom—the right to modify one's body and mind via biotechnology, AI, or nanotechnology—to overcome aging, disease, cognitive bounds, and mortality. This framework affirms the desirability of transitioning to posthuman states, guided by life-promoting values and applied reason. Philosophers like reinforce these underpinnings by framing as an outgrowth of , committed to accelerating intelligent life's beyond limitations through , while critiquing apologism—the notion that altering conditions is inherently wrong. Core tenets include confidence in technology's for net benefits, such as vastly extended healthy lifespans and , balanced against risks like existential threats, yet grounded in empirical rather than utopian guarantees.

Historical Development

Early Precursors

The pursuit of human enhancement beyond natural biological limits traces back to ancient civilizations, where quests for reflected early aspirations to transcend mortality. In the Epic of Gilgamesh, composed around BCE, the titular seeks eternal life after the death of his companion , obtaining a rejuvenating from the but ultimately failing when it is stolen by a , symbolizing the frustration of such endeavors through mythical means. Ancient Greek mythology provided further precursors through figures embodying technological defiance of human constraints. Prometheus stole fire from the gods to bestow advanced capabilities upon humanity, enabling crafts and knowledge that elevated human potential, though punished with eternal torment for overreaching. Similarly, Daedalus engineered wings for himself and his son Icarus, attempting flight as a form of bodily augmentation, with Icarus's fatal hubris underscoring risks of unchecked enhancement. Medieval alchemy represented a proto-scientific attempt to achieve physical immortality and human perfectibility. Alchemists pursued the elixir vitae to conquer aging and death, alongside efforts to create artificial life such as homunculi, as defended by 13th-century scholars like and against theological opposition. These pursuits blended empirical experimentation with esoteric goals, laying groundwork for later chemical and biological sciences aimed at bodily . During the Renaissance, philosophical humanism emphasized human agency in self-directed evolution. Giovanni Pico della Mirandola's Oration on the Dignity of Man (1486) argued that humans, lacking fixed form, could ascend toward divine likeness through intellect and will, positioning humanity as architects of its own nature rather than passive recipients of fate. Enlightenment thinkers advanced these ideas toward empirical science as a tool for human dominion over biology. Francis Bacon, in Novum Organum (1620), promoted inductive method to expand human powers and relieve suffering, while his utopian New Atlantis (published posthumously 1627) depicted a society using advanced "Salomon's House" laboratories for medical prolongevity, mechanical prosthetics, and environmental control to enhance life. René Descartes, in Discourse on the Method (1637), envisioned mechanistic medicine treating the body as a machine repairable to defeat diseases and senescence, enabling mastery over health akin to engineering. Marquis de Condorcet, in Sketch for a Historical Picture of the Progress of the Human Mind (1795), forecasted indefinite life extension through perfected sciences, rejecting natural death as an artifact conquerable by reason. Benjamin Franklin (1706–1790) experimented with electrical resuscitation and expressed desires for suspended animation to await future revivals, bridging personal aspiration with proto-cryonic concepts. In the 19th century, synthesized religious and scientific imperatives for transcendence. Nikolai Fyodorov (1829–1903), a philosopher and librarian, advocated "active " wherein would harness to achieve physical , resurrect all past dead via scientific of atoms, and regulate to eliminate , framing these as moral duties rooted in familial and cosmic rather than mere individual gain.

Emergence of Modern Transhumanism

The transhumanist coalesced in the late amid growing in applying to overcome biological limitations, distinguishing itself from earlier speculative ideas by emphasizing practical, optimistic for . A foundational step was the of the inaugural of Extropy: The Journal of Transhumanist Thought in by philosopher Max More and legal Tom Morrow (later Tom Bell), which introduced extropianism as a set of principles promoting boundless expansion, self-direction, and dynamic optimism through rational technological progress. In 1990, More further defined the philosophy in his essay "Transhumanism: Towards a Futurist Philosophy," advocating for the use of science, reason, and market incentives to achieve indefinite lifespan extension, superintelligence, and personal morphological freedom. The Extropy Institute, co-founded by More in 1992, served as the first dedicated organization to advance these concepts, organizing conferences, newsletters, and online forums that attracted intellectuals focused on cryonics, nanotechnology, and artificial intelligence as tools for transcending humanity. This period also saw contributions from figures like K. Eric Drexler, whose 1986 book Engines of Creation popularized molecular nanotechnology as a means for precise matter manipulation and human augmentation, influencing transhumanist discussions on engineering superior bodies and minds. Concurrently, futurist FM-2030 (Fereidoun M. Esfandiary) bridged earlier optimism with modern rhetoric through his 1989 book Are You a Transhuman?, which provided a diagnostic framework for evaluating one's adaptability to rapid technological change and predicted widespread human optimization by 2030. By the mid-1990s, had evolved into a networked via and early platforms, setting the stage for broader institutionalization. The founding of the Transhumanist (WTA) in by ethicist and philosopher Pearce marked a , creating an nonprofit to coordinate , ethical , and public on enhancement technologies while issuing declarations on responsible . This organization, later rebranded Humanity+, helped legitimize transhumanism within academic and policy circles by prioritizing evidence-based risks and benefits over unsubstantiated utopianism.

Key Milestones

In 1957, coined the "" in his "," envisioning a where transcends its biological limitations through scientific and technological means. This marked a pivotal shift from philosophical to an explicit for . The saw the practical of as a transhumanist strategy for life extension, with Robert Ettinger's 1964 book The Prospect of Immortality proposing the freezing of human bodies for revival using advanced technology. This led to the founding of the Alcor Life Extension Foundation in 1972, which developed vitrification techniques to preserve biological structures at cryogenic temperatures. Similarly, the Cryonics Institute was established in 1976 to provide affordable full-body suspension services. The 1980s and 1990s formalized as an organized . Drexler's 1986 introduced the of for atomic-scale of , including augmentation, and prompted the founding of the Foresight Institute to guide its ethical development. In 1988, and Morrow launched , which evolved into the Extropy Institute by 1992, promoting principles like boundless expansion and self-transformation through technology. further refined the definition of in his 1990 , distinguishing it from by emphasizing enhancement without abandoning values. The late 1990s witnessed institutional consolidation, with and David Pearce founding the World Transhumanist Association (now Humanity+) in 1998, which issued the first Transhumanist Declaration outlining goals such as overcoming aging, cognitive enhancement, and equitable access to enhancements. This was complemented by the establishment of for and in 2004 to address implications of enhancement technologies. In the 2000s, Kurzweil's book popularized the idea of a , predicting exponential progress in and leading to radical human transformation by 2045. The Foundation's founding in accelerated anti-aging , supporting initiatives like the for breakthroughs. These milestones underscore transhumanism's from ideas to a structured advocacy for technology-driven human evolution.

Key Figures and Organizations

Influential Thinkers

Julian Huxley, an evolutionary biologist and the first Director-General of UNESCO from 1946 to 1948, coined the term "transhumanism" in his 1957 essay "Transhumanism," where he envisioned humanity transcending its biological limitations through scientific and technological means to achieve greater fulfillment. Huxley's formulation emphasized evolutionary progress beyond the human condition, stating, "man remaining man, but transcending himself, by realizing new possibilities of and for his human nature." His ideas built on earlier evolutionary humanism, influencing subsequent thinkers by framing transhumanism as a naturalistic successor to traditional religion. Fereidoun M. Esfandiary, known as , was a Belgian-born Iranian-American who popularized transhumanist in the late through works like Are You a Transhuman? (), which included a self-diagnostic test to assess one's alignment with transhuman ideals such as embracing technology for personal evolution. Born in 1930, FM-2030 advocated for a shift from "animal-human" biology to "transhuman" enhancements, predicting by 2030 humans would achieve widespread physical and cognitive upgrades via biotechnology and cybernetics. He exemplified these principles by opting for cryonic preservation upon his death in 2000, viewing it as a bridge to future revival technologies. Max More, born in 1964, advanced transhumanism through extropianism, a philosophy he defined in his 1990 essay "Transhumanism: Toward a Futurist Philosophy," which outlined principles like boundless expansion, self-transformation, and dynamic optimism to overcome human limits. As founder of the Extropy Institute in 1992, More promoted proactive technological progress, influencing organizational efforts in cryonics and life extension; he later served as CEO of the Alcor Life Extension Foundation. His work emphasized individual agency in morphological freedom, critiquing static humanism in favor of perpetual self-upgrading. Nick Bostrom, a Swedish philosopher born in 1973, co-founded the World Transhumanist Association (now Humanity+) in 1998, providing an institutional platform for advocating enhancements in cognition, healthspan, and resilience against existential risks. In essays like "Transhumanist Values" (2001), Bostrom articulated core tenets such as exploring posthuman states while prioritizing diversity and informed consent in technological adoption. His 2004 paper "A History of Transhumanist Thought" traces intellectual lineage from precursors like J.B.S. Haldane to modern applications, underscoring ethical frameworks for superintelligence and longevity. Ray Kurzweil, an American inventor and futurist born in 1948, has propelled transhumanist discourse through predictions of the technological singularity, detailed in The Singularity Is Near (2005), where he forecasts by 2045 the merger of human and machine intelligence enabling indefinite lifespan extension via nanotechnology and AI. Kurzweil's law of accelerating returns, based on empirical trends in computing power doubling roughly every 18 months since the 1930s, underpins his advocacy for uploading consciousness and reversing aging through molecular repair. As Director of Engineering at Google since 2012, he integrates these ideas into practical AI development, projecting radical abundance by mid-century. Aubrey de Grey, a gerontologist born in , focuses on negligible senescence via the () , targeting seven types in aging cells for repair to achieve "longevity escape velocity" by 2036–2040 for those alive today. Founding the in , de Grey's approach treats aging as a solvable problem rather than inevitable entropy, amassing over $25 million in funding by 2015 for preclinical trials in damage-repair therapies like allotopic expression of mitochondrial genes. Though he rejects the transhumanist label personally, his work aligns with core goals of radical life extension, influencing biotech investments exceeding $1 billion annually in anti-aging by 2020.

Major Organizations and Initiatives

The , established in 1992 by and Tom Morrow following the launch of Extropy in , served as a foundational organization in , promoting —a centered on boundless , self-transformation, and technological advancement to counter and constraints. It organized conferences, published newsletters, and fostered among early proponents until disbanding in , after declaring its core objectives largely integrated into broader . Humanity+, originally the World Transhumanist Association founded in by philosophers and Pearce, operates as the leading international nonprofit membership organization dedicated to advocating the ethical application of for , including extension and cognitive augmentation. It maintains the Transhumanist , updated in , and supports and discussions on responsible technological . The Institute for and (IEET), launched in 2004 as a technoprogressive , analyzes the societal impacts of innovations like and , emphasizing their potential to enhance , , and in democratic contexts while addressing risks through recommendations. It publishes the of and and hosts affiliates focused on ethical frameworks for transformative advancements. The , initiated in 2011 by entrepreneur , constitutes a prominent pursuing radical via cybernetic means, including the for transferring into holographic or robotic embodiments by 2045. It coordinates in , , and to develop prototypes for non-biological . Political entities like the U.S. , formed in 2014 under Stolyarov, represent transhumanist in , endorsing platforms for accelerated scientific , morphological freedom, and opposition to age-related through evidence-based policies. Similar parties have emerged in including the and Italy, aiming to embed enhancement technologies into legislative agendas.

Technological Foundations

Biotechnology and Longevity Research

in transhumanist thought emphasizes interventions to repair or reprogram biological aging processes, aiming for indefinite healthy lifespan extension through targeted molecular therapies. Proponents argue that aging results from accumulative cellular and tissue damage, addressable via , gene editing, and senescent cell clearance, rather than mere disease treatment. from models supports partial of age-related decline, though remains by of systemic interactions and off-target effects. The () , proposed by biomedical gerontologist , outlines seven categories of aging —including , mitochondrial , and extracellular aggregates—for periodic repair using biotechnologies like replenishment and lysosomal enhancement. Established as the in , the has funded preclinical studies demonstrating feasibility in mice, such as allotopic expression of mitochondrial genes to mitigate . Despite de Grey's departure amid unrelated allegations, continues advocating damage-repair paradigms, influencing by shifting from slowing aging to comprehensive . Gene editing technologies, particularly -Cas9 developed in , enable precise modification of aging-associated , such as those regulating , epigenetic clocks, or pathways. In settings, has rejuvenated senescent cells by targeting p16INK4a and other markers, restoring proliferative in aged mice tissues. applications remain exploratory; for instance, Yamanaka factors for partial cellular has extended mouse lifespan by up to 30% in controlled studies, but risks like tumorigenesis necessitate causal validation beyond correlative biomarkers. Transhumanist advocates view these as foundational for transcending genetic limits, though critics evolutionary trade-offs where correlate with reduced or cancer in populations. Senolytics, compounds selectively eliminating senescent cells that secrete pro-inflammatory factors (SASP), represent another biotech , with preclinical showing 20-30% lifespan extension in mice via drugs like . Clinical trials, including a 2019 pilot in diabetic patients, confirmed senescent cell reduction without severe adverse events, while a 2025 in adults assessed cognitive and improvements post-intermittent dosing. Biotechnology's trials for ophthalmic conditions reported modest gains in 2, underscoring potential for frailty , yet endpoints require longitudinal amid senescence's heterogeneous roles in . Prominent organizations driving this research include , launched in 2021 with $3 billion funding from investors like , focusing on cellular reprogramming for age reversal; the Buck Institute for Research on Aging, operational since 2002, which elucidated hallmarks like genomic ; and Life Sciences, Alphabet-backed since 2013, targeting interventions in yeast, worms, and mice models. These efforts have accelerated senomorphic and epigenetic therapies, with over 20 senolytic candidates in pipelines by 2025, though regulatory hurdles persist due to aging's non-disease status under FDA frameworks. Transhumanist integration posits biotech convergence with for personalized protocols, prioritizing empirical biomarkers like clocks over speculative claims.

Artificial Intelligence and Neural Interfaces

Artificial intelligence (AI) and neural interfaces represent core technological pillars in transhumanist aspirations to augment human cognition and achieve symbiosis between biological brains and computational systems. Transhumanists advocate for AI not merely as an external tool but as an integrable extension of intelligence, potentially enabling superhuman reasoning and problem-solving through direct neural linkages. This vision posits that advanced AI could amplify cognitive capacities, allowing humans to process vast datasets, simulate complex scenarios, and overcome biological constraints on and . Such enhancements are theorized to facilitate a "cognitive ," where human-AI accelerates innovation beyond current evolutionary limits. Neural interfaces, particularly brain-computer interfaces (BCIs), provide the hardware foundation for this integration by enabling bidirectional communication between neurons and digital systems. Early BCI prototypes, developed since the 1970s, focused on recording neural signals for basic control of cursors or prosthetics, but recent advances emphasize high-channel-count implants with thousands of electrodes to capture fine-grained brain activity. For instance, Utah arrays and silicon-based probes have evolved into flexible, biocompatible materials like carbon nanotubes and polymers, reducing tissue damage and improving signal stability over months-long implants. These interfaces decode motor intentions or sensory inputs via machine learning algorithms, translating spikes into commands with latencies under 100 milliseconds. Prominent developments include Neuralink's N1 implant, a wireless with 1,024 electrodes threaded into the by robotic surgery, first tested in humans in January 2024 for quadriplegia patients to control computers via thought. By July 2025, had implanted the in its ninth participant, demonstrating cursor control, gaming, and rudimentary speech decoding in clinical trials like PRIME and , which target restoration. The company raised $650 million in Series E in 2025 to trials, achieving FDA Breakthrough Designation for speech applications, with participants reporting bandwidth increases to over 100 bits per second. Beyond medical restoration, transhumanist proponents view such systems as precursors to elective enhancements, like uploading skills or interfacing with AI for augmented decision-making, though current implementations remain limited to therapeutic contexts due to biocompatibility and decoding accuracy challenges. AI integration with neural interfaces amplifies these capabilities through closed-loop systems, where real-time feedback adapts stimulation to user intent, as seen in DARPA-funded projects combining deep learning with electrocorticography for epilepsy treatment and potential cognitive boosting. Peer-reviewed studies highlight AI's role in enhancing signal processing, with convolutional neural networks improving decoding fidelity by 20-30% in non-invasive EEG setups, paving the way for hybrid human-AI cognition. In transhuman frameworks, this convergence could enable "whole brain emulation," digitizing neural patterns for substrate-independent minds, though empirical evidence remains confined to animal models and low-fidelity human trials, with no verified instances of consciousness transfer. Ongoing research prioritizes scalability, with 2025 advancements in optical and ultrasonic interfaces exploring non-invasive alternatives to invasive implants for broader adoption.

Nanotechnology and Cybernetic Enhancements

in the of envisions nanoscale machines capable of repairing cellular , biological processes, and augmentation, as theorized by early proponents like in his 1986 , which proposed molecular assemblers for atom-by-atom construction. Current applications remain focused on interventions rather than full enhancement, with nanobots primarily in experimental stages for and diagnostics; for instance, ultrasound-driven nanorobots have shown promise in preclinical trials for precise tumor targeting, though routine clinical use is not yet achieved 2025. The global nanorobots healthcare , valued at USD 9.15 billion in 2024, is to reach USD 38.66 billion by 2034, driven by multifunctional designs that combine and therapeutic functions, indicating incremental toward transhumanist goals like tissue repair. However, self-replicating or general-purpose nanobots capable of widespread human enhancement remain speculative, limited by challenges in biocompatibility, power supply, and control at the atomic scale. Cybernetic enhancements involve the of , , or robotic systems with to restore or exceed natural capabilities, aligning with transhumanist aims of merging with machinery for superior strength, , or sensory input. Advances in bionic prosthetics exemplify this, such as MIT's 2024 neural-controlled leg , which uses targeted muscle reinnervation to directly with the nervous system, enabling amputees to achieve near-natural patterns with reduced metabolic compared to conventional devices. AI-integrated bionic arms, like those developed by Atom Limbs in 2024, provide multi-articulated dexterity approximating full motion range through pattern recognition algorithms that interpret electromyographic signals, surpassing earlier myoelectric prosthetics in responsiveness. Exoskeletons represent another frontier, with powered suits enhancing load-bearing capacity for able-bodied users; for example, military-grade systems by 2023 allow soldiers to carry up to 100 with minimal , demonstrating potential for augmentation in labor-intensive tasks. These developments prioritize empirical functionality over speculative superhumanism, with ongoing emphasizing and sensory to minimize rejection risks, though long-term durability and ethical integration into non-medical enhancement remain unresolved.
TechnologyKey AdvanceYearSource
Nanorobots for drug Hybrid multifunctional designs for tumor targeting2025 projections
Neural-controlled bionic Restores natural via muscle reinnervation2024
AI-powered bionic armFull via EMG pattern recognition2024
Enhances load capacity to 100 kg2023 trials

Auxiliary Methods like Cryonics

Cryonics involves the post-mortem preservation of remains, typically the or entire , at cryogenic temperatures in , predicated on the speculative possibility that technological advancements could repair and restore biological . In transhumanist discourse, it serves as an auxiliary strategy to the to more advanced longevity interventions, such as molecular repair or , by halting further after . Proponents argue that low temperatures thermodynamically slow metabolic processes and molecular , preserving potentially recoverable via , though this remains unproven and hinges on unverified assumptions about capabilities. The concept gained traction in the mid-20th century, with Robert Ettinger's 1964 book The Prospect of Immortality articulating the rationale for as a rational gamble against irreversible . Early organizations emerged in the 1960s, including the founded by in 1963, which evolved into formal cryopreservation efforts. The (CI), established in 1976 by Ettinger in , offers whole-body preservation, while , founded in 1972 in , provides both whole-body and neuropreservation options. Internationally, KrioRus in operates similarly, storing bodies in . As of recent reports, fewer than individuals have undergone cryopreservation worldwide, with CI maintaining around 230 patients and Alcor approximately 200. The procedure commences immediately after to minimize ischemic , involving surgical with cryoprotectant solutions to achieve vitrification—a glass-like solidification that avoids formation and associated fracturing. Remains are then cooled to -196°C for indefinite storage, with costs ranging from $28,000 for CI whole-body suspension (funded often via ) to $200,000 or more at Alcor, excluding standby and fees. No mammalian revivals from cryopreservation have occurred, and success in humans would require not only thawing without further degradation but also repairing pre-freeze injuries like oxygen deprivation, which destroys synaptic connections within minutes. Mainstream scientific critique deems implausible, citing irreversible cellular and structural damage from toxicity, fracturing, and denaturation that current cannot mitigate, rendering biologically impossible under known physics and chemistry. Cryobiologists note that while small-scale succeeds for embryos or organs, scaling to whole brains fails due to uneven and cryoprotectant limitations, with no empirical pathway to information-theoretic preservation of . Proponents counter that criticisms overlook potential molecular scanning and reconstruction, but this defense lacks experimental validation and is dismissed by skeptics as in undefined rather than evidence-based . Institutional reluctance to engage stems from risks and the procedure's classification outside legitimate science, with organizations like CI and Alcor operating as for-profit or nonprofit entities without peer-reviewed protocols.

Representations in Culture and Fiction

Transhumans in Literature and Media

Transhuman figures appear prominently in science fiction literature, often embodying enhancements through cybernetic implants, genetic modification, or consciousness uploading, while grappling with philosophical questions of identity, mortality, and human essence. Mary Shelley's Frankenstein (1818) serves as an early precursor, depicting Victor Frankenstein's creation of a reanimated being with superhuman strength and intellect, which critiques unchecked ambition in biological augmentation. William Gibson's Neuromancer (1984) introduced cyberpunk tropes of neural interfaces and direct brain-computer links, portraying "console cowboys" who transcend physical limits via cyberspace immersion, influencing subsequent depictions of merged human-machine cognition. Later works like Greg Egan's Permutation City (1994) explore digital immortality, where simulated minds persist in virtual substrates, questioning the continuity of self amid computational substrates. Post-2000 literature intensified focus on radical transformation. Charles Stross's Accelerando (2005) chronicles a family's navigation of the , featuring economic uploads, symbiosis, and post-biological entities adapting to . Richard K. Morgan's Altered Carbon (2002) presents cortical stacks enabling consciousness transfer between synthetic or cloned bodies, commodifying immortality among elites while highlighting class divides in access to such enhancements. Vernor Vinge's A Fire Upon the Deep (1992) depicts zones of varying , with transhuman posthumans achieving godlike capabilities through networked minds, underscoring risks of uneven . These narratives frequently aspirational augmentation with dystopian outcomes, such as of or existential . In film, transhumanism manifests through visual explorations of bodily reconstruction and cognitive expansion. Ridley Scott's Blade Runner (1982) features replicants—bioengineered humans with superior strength and lifespan—as hunted entities, probing the boundaries of engineered sentience and ethical replication. RoboCop (1987), directed by Paul Verhoeven, portrays Alex Murphy's resurrection as a cybernetic , emphasizing corporate over human-machine hybrids and the erosion of . Andrew Niccol's Gattaca (1997) illustrates genetic pre-selection for traits, where "valids" , critiquing deterministic enhancement and against unaltered "in-valids." More recent entries like Transcendence (2014) depict a scientist's mind uploaded into a superintelligent AI, raising concerns over uncontrolled growth and loss of humanity. Television series have adapted these themes for serialized depth. The Netflix adaptation of Altered Carbon (2018–2020) expands Morgan's novel with cortical stacks facilitating "sleeving" across bodies, portraying a future where physical form is disposable for the wealthy, yet fraught with identity crises and social upheaval. HBO's Westworld (2016–2022) features android hosts evolving toward human-like consciousness via iterative programming and memories, blurring lines between organic and synthetic transhumans in a theme park simulation. Anthology formats like Black Mirror (2011–present) episodically dissect neural enhancements and digital afterlives, such as in "San Junipero," where minds upload to simulated paradises, often warning of psychological fragmentation. These media portrayals commonly highlight dual potentials: empowerment through transcendence versus dehumanization, informed by contemporaneous technological anxieties rather than unalloyed optimism.

Debates Reflected in Fiction

Science fiction has long served as a medium for exploring transhumanist debates, juxtaposing visions of technological transcendence against warnings of , , and existential risks. Works portraying utopian outcomes emphasize enhanced , cognitive expansion, and societies, arguing that human augmentation could liberate individuals from biological constraints and foster unprecedented . In contrast, dystopian narratives highlight ethical , such as the of , social based on to enhancements, and the of , prompting reflections on whether such advancements preserve or undermine values. Utopian depictions, such as Iain M. Banks' (beginning with Consider Phlebas in 1987), envision a galactic where humans and AIs coexist in a , with citizens uploading minds into artificial bodies or vast starships, achieving and boundless without . Banks' reflects transhumanist by illustrating how neural enhancements and symbiotic AI enable self- and ethical in lesser societies, portraying augmentation as a pathway to enlightened anarchy rather than tyranny. Similarly, Greg Egan's Diaspora (1997) extrapolates a posthuman era where consciousness is digitized and dispersed across simulations, debating the continuity of identity amid quantum-scale uploads while affirming the potential for intellectual evolution beyond flesh-bound limits. These stories counterbalance critiques by suggesting that deliberate technological evolution, grounded in advanced computation, could resolve scarcity-driven conflicts and amplify human potential without sacrificing agency. Dystopian fiction, however, frequently underscores transhumanism's hazards through scenarios of genetic determinism and cybernetic alienation. Aldous Huxley's Brave New World (1932) prefigures ethical objections by depicting a stratified society sustained through embryonic conditioning and soma-induced bliss, critiquing enhancement as a mechanism for engineered conformity that supplants genuine emotion and individuality with stability. The 1997 film Gattaca extends this to genetic engineering, where "valids" engineered for superiority dominate, exposing debates on meritocracy versus discrimination as an "invalid" protagonist resorts to identity fraud to compete, illustrating how unequal access to biotech could entrench class divides and devalue natural human variation. William Gibson's Neuromancer (1984) probes cybernetic fusion in a noir sprawl, where console cowboys jack into matrices via neural implants, but at the cost of bodily obsolescence and corporate enslavement, reflecting concerns that transhuman interfaces might amplify exploitation rather than empower users. Such portrayals, drawn from cyberpunk roots, argue that without robust safeguards, enhancements risk transforming humanity into fragmented, market-driven constructs, prioritizing survival in simulated realms over embodied existence. These fictional reflections often intersect real-world debates, with utopian works inspiring proponents like those advocating AI-human symbiosis for , while dystopias fuel skeptics' fears of , such as loss of in or power imbalances favoring elites. Authors like Egan embed rigorous extrapolations from physics and to substantiate possibilities, whereas cautionary tales like Huxley's rely on psychological realism to question if quantified equates to fulfillment. Overall, fiction does not resolve these tensions but amplifies them, urging of transhumanist trajectories through simulations of enhancement's causal chains—from to societal reconfiguration.

Criticisms and Controversies

Ethical and Existential Objections

Critics of transhumanism raise ethical concerns centered on the erosion of dignity, which they argue derives from our shared, unenhanced biological nature shaped by . , in a 2004 analysis, labeled transhumanism "the world's most dangerous idea" due to its potential to modify , interlinked human traits—such as linking self-defense to or to —in ways that yield unpredictable and potentially dehumanizing outcomes. He contends that such enhancements would fracture the egalitarian foundation of and , as "enhanced creatures" might assert superior claims over unaltered humans, exacerbating social divisions. Bioethicist Leon Kass invokes the "wisdom of repugnance" toward radical enhancements like genetic engineering or mood-altering biotechnologies, viewing them as violations of authentic human striving that undermine character formation through effort and limitation. Kass argues that interventions bypassing natural processes—such as memory erasure or procreation in advanced age—devalue the finitude integral to human excellence, procreation, and virtue, transforming life into a mere prolongation rather than a coherent narrative shaped by decline and renewal. Existential objections highlight how transhumanist goals, particularly immortality via life extension or mind uploading, could strip existence of inherent meaning by eliminating the constraints of mortality that foster urgency, aspiration, and relational depth. Without death's shadow, critics like Kass warn, human endeavors lose their poignant drive, potentially yielding boredom, intergenerational conflict, and a diminished appreciation for transient goods like youth or legacy. Fukuyama extends this to broader perils, suggesting that overriding evolutionary destiny invites cascading failures in our "miraculously complex" form, risking not enhancement but the loss of what defines purposeful human agency. These positions underscore a causal realism: human flourishing emerges from adapting to inherent limits rather than engineering them away, with empirical precedents in historical overreaches—like eugenics programs of the early 20th century—illustrating how enhancement pursuits often amplify inequalities and unintended harms without verifiable gains in well-being.

Scientific and Empirical Skepticism

Critics of transhumanist goals, particularly those involving , argue that many foundational claims lack empirical support and confront fundamental biological and physical constraints. For instance, projections of achieving ""—where life expectancy increases faster than time passes—have been advanced by proponents like , who in 2021 estimated a 50% chance by 2036, yet demographic analyses of historical mortality data indicate that without interventions slowing the aging process itself, to age 100 is unlikely to exceed 15% for females and 5% for males even by century's end. These limits stem from observations that maximum human lifespan has plateaued around 115-120 years despite medical advances, with recent studies reinforcing that extension beyond current ceilings remains implausible under prevailing biological dynamics, including telomere shortening, , and accumulated genomic instability. In biotechnology and , empirical setbacks overoptimism; while incremental gains like caloric restriction mimetics or senolytics show in model organisms, human trials as of 2024 have yielded modest healthspan improvements without reversing core aging hallmarks, such as the on divisions. Transhumanist visions of indefinite lifespan extension via comprehensive repair of age-related ignore thermodynamic realities, where in complex biological systems progressively degrades repair , a point echoed in critiques highlighting that no peer-reviewed demonstrates scalable of multi-organ in mammals. Skepticism extends to nanotechnology, where Eric Drexler's 1980s concept of self-replicating molecular assemblers for atom-by-atom construction—central to transhumanist manufacturing of enhancements—faced rigorous challenge in the 2003 Drexler-Smalley debate. Nobel laureate Richard Smalley contended that such devices violate chemical principles, citing issues like the "sticky fingers" problem (uncontrolled adhesion preventing precise manipulation) and the "fat fingers" dilemma (manipulator tips too bulky for atomic precision), rendering positional assembly infeasible without violating quantum mechanics or Brownian motion at nanoscale. Despite decades of progress in nanomaterials, no experimental validation of Drexlerian assemblers has emerged, with mainstream nanotechnology focusing instead on top-down fabrication or bio-inspired methods that fall short of the exponential replication promised for cybernetic or tissue engineering breakthroughs. Cryonics, posited as an auxiliary to future revival technologies, encounters profound empirical hurdles; involves to avert , but even optimized protocols widespread cellular fracturing, protein denaturation, and ischemic to cooling, with no successful large-scale mammalian revival demonstrated. Mainstream cryobiologists it as pseudoscientific, lacking that nanoscale repair of such diffuse cryoprotectant toxicities and structural disruptions could restore viability, let alone , given current biophysical limits on reversing . Mind uploading or whole-brain emulation, a for transcending biological substrates, remains speculative without empirical grounding; while maps static wiring in simple like C. elegans, replicating dynamic electrochemical states, , and —hallmarks of —eludes current , as scans destructive to tissue fail to capture real-time quantum or glial influences. Doubts persist on whether substrate-independent duplication preserves , with philosophical and empirical critiques noting that even perfect yields a copy, not , per continuity of arguments, untested amid absent proofs of digital emergence beyond narrow AI. Overall, transhumanism's empirical is critiqued for exceeding , with peer-reviewed analyses attributing persistent shortfalls to systemic overpromising in speculative fields, where institutional biases toward novelty may inflate feasibility claims absent rigorous falsification. This pattern mirrors historical tech forecasts, where progress assumptions overlook causal bottlenecks like in evolved systems.

Socioeconomic and Political Implications

Transhumanist pursuits, particularly in human enhancement technologies such as genetic editing and neural interfaces, are poised to exacerbate existing socioeconomic inequalities by restricting initial access to those with substantial financial resources. Early adopters of costly interventions—like CRISPR-based therapies estimated at $500,000–$1 million per treatment in clinical trials as of 2023—have historically been limited to high-income demographics, akin to the diffusion of luxury medical procedures such as personalized cancer immunotherapies. This pattern risks entrenching a class divide, where enhanced individuals gain competitive advantages in labor markets, education, and longevity, potentially rendering unenhanced populations economically obsolete. Critics, including bioethicists, argue that without redistributive mechanisms, such disparities could mirror historical technological gradients, amplifying wealth concentration rather than meritocratic mobility. Proponents counter that market-driven innovation will democratize enhancements over time, citing plummeting costs in from $100 million per in 2001 to under $1,000 by 2020, yet empirical trends in elective enhancements like cosmetic neural implants suggest persistent barriers for lower socioeconomic strata. In labor , transhumanist and augmentation could displace up to 800 million globally by 2030 according to projections, disproportionately affecting low-skill workers unable to afford compensatory upgrades, thereby fueling underemployment and social unrest. This socioeconomic strain may necessitate or enhancement subsidies, though fiscal analyses indicate such policies could strain public budgets amid aging populations extended by elite longevity escapes. Politically, transhumanism intersects with ideological divides, often aligning with libertarian for minimal to accelerate , as articulated by figures like , who envision exponential diffusion mitigating divides. Conversely, bioconservatives and egalitarian frameworks decry enhancements as eroding foundational to , positing that unequal undermines democratic legitimacy by creating castes stratified by biological . Regulatory debates, evident in 2024 U.S. congressional hearings on AI-driven enhancements, highlight tensions between innovation incentives and mandates for equitable distribution, with proposals like the European Union's AI imposing risk-based oversight that could slow in favor of safety nets. Transhumanist political movements, such as Zoltan Istvan's 2016 U.S. presidential bid, have pushed for "equal " platforms, but implementation faces resistance from state-centric models wary of privatized eugenics-like outcomes. Ultimately, unchecked advancement risks concentrating power in oligarchies, as entities like enhancements, prompting calls for treaties to avert geopolitical imbalances akin to disparities.

Recent Developments and Prospects

Advancements as of 2025

As of 2025, brain-computer interfaces (BCIs) have advanced significantly in human trials, with reporting multiple implants enabling participants to control devices via thought, including cursor and interactions, following FDA approval for expanded trials in 2024. In its summer 2025 , detailed with new participants surpassing 100 days post-implant, demonstrating improved and signal for tasks like digital . The company announced plans for a dedicated trial targeting speech impairments, building on demonstrations of decoded neural activity for communication. Complementary developments include Stanford's BCI system, which in August 2025 detected inner speech in speech-impaired patients with 70-80% accuracy, and UC Davis's 2 enabling an patient to generate speech at 62 words per minute. Gene editing technologies, particularly CRISPR variants, reached new clinical milestones, with the first personalized therapy administered to a with a at in May 2025, targeting specific mutations . , a more precise CRISPR derivative, was trialed in a human patient for the first time in May 2025, aiming to correct genetic defects with minimal off-target effects. Advancements extended to neurological applications, as August 2025 research demonstrated improved delivery methods for brain genome editing, reducing risks in animal models and paving the way for human trials in neurodegenerative diseases. In cardiovascular therapy, Verve Therapeutics' CRISPR-based treatments advanced after acquisition by Eli Lilly in June 2025, with ongoing trials showing base editing efficacy in lowering cholesterol levels. Cybernetic prosthetics incorporated sensory feedback and biological integration, exemplified by MIT's July 2025 bionic knee prosthesis, which osseointegrates with and to restore , allowing users to walk 20% faster and navigate stairs with reduced expenditure compared to models. Johns Hopkins University's March 2025 robotic hand prosthesis achieved adaptive grasping of varied objects, such as toys and bottles, by conforming grips via embedded sensors mimicking human dexterity. An Osaka startup unveiled a bionic hand in May 2025 replicating 95% of motions, integrated with neural signals for intuitive , set for at Expo 2025. University of Chicago research in January 2025 enhanced prosthetic limbs with BCI-driven tactile feedback, enabling users to perceive and gradients. Longevity research yielded empirical gains in preclinical models, with a May 2025 Scripps Research AI platform identifying compounds that extended worm and yeast lifespans by over 70% while preserving healthspan markers like mobility. These candidates targeted senescence pathways, corroborated by mouse studies showing delayed age-related decline in tissues. Biotech firms like Altos Labs advanced cellular reprogramming techniques, reporting partial epigenetic age reversal in primate fibroblasts by mid-2025. However, human trials remained limited to safety phases for senolytics and NAD+ boosters, with no verified extension of maximum lifespan beyond observational correlations in calorie restriction analogs.

Persistent Challenges

Efforts to radically extend human lifespan have encountered biological complexity, where aging involves interdependent processes like genomic instability, telomere attrition, epigenetic alterations, loss of , deregulated nutrient sensing, mitochondrial dysfunction, , stem cell exhaustion, and altered intercellular communication—collectively termed the "." Interventions targeting individual hallmarks, such as drugs that clear senescent cells, have extended lifespan in mice by up to 30% in some studies but yield inconsistent or negligible results in and humans due to compensatory mechanisms and off-target effects. As of 2025, clinical trials for anti-aging therapies like metformin repurposing or NAD+ boosters report metabolic improvements but no reversal of chronological aging, underscoring the causal entanglement of these processes that defies modular fixes. Mind uploading, the transfer of consciousness to digital substrates, persists as a core yet unachievable transhumanist aim, hampered by unresolved issues in neuroscience and computation. The human brain comprises approximately 86 billion neurons and 100 trillion synapses, requiring nanoscale mapping and real-time simulation at molecular fidelity, which exceeds current exascale computing capacities by orders of magnitude even for partial models. Theoretical obstacles include the "hard problem" of consciousness—whether subjective experience emerges computably from physical states—and debates over substrate independence, with critics arguing that quantum effects or non-local properties preclude faithful emulation without destroying the original. Empirical progress lags: while connectomics has reconstructed small animal brains (e.g., C. elegans or Drosophila), scaling to humans demands petabyte-scale data storage and algorithms unproven for dynamic, plastic neural activity, with no validated path to preserving personal identity post-upload. Integration of cybernetic enhancements introduces biocompatibility and safety barriers, as neural implants like those from demonstrate basic in trials but suffer from tissue scarring, signal degradation over time, and immune rejection, limiting long-term functionality. Systemic enhancements, such as genetic editing via for cognitive boosts, risk unintended pleiotropic effects, including cancer predisposition or heritable mutations, as evidenced by off-target edits in early human embryo trials halted in due to mosaicism and efficacy shortfalls. These challenges persist amid regulatory scrutiny, with ethical oversight bodies emphasizing empirical validation over speculative promises, revealing transhumanism's tension between ideological optimism and causal realism in complex biological systems.

Realistic Future Trajectories

Realistic assessments of transhumanist futures emphasize incremental technological integration over speculative leaps like or immediate immortality, constrained by biological complexity, regulatory barriers, and empirical validation gaps. Advances in brain-computer interfaces (BCIs), such as Neuralink's 2024 human trials demonstrating cursor control via thought for paralyzed individuals, suggest near-term applications in restoring lost functions rather than cognitive superenhancement, with scalability limited by surgical risks and signal fidelity issues. Similarly, CRISPR-based gene editing has achieved targeted therapies for conditions like , approved by the FDA in 2023, but broad human augmentation faces hurdles from off-target effects and ethical restrictions on modifications. In longevity research, trajectories point to modest healthspan extensions through senolytics and partial , as evidenced by studies extending lifespan by 10-20% via Yamanaka factors, yet human translation remains uncertain due to cancer risks and systemic aging's multifactorial nature. Aubrey de Grey's framework posits "" by 2036-2040 via comprehensive damage repair, but critiques highlight overreliance on unproven scaling from animal models, with human trials like those for metformin repurposing showing only marginal benefits in ongoing studies as of 2025. AI-driven , accelerating candidate identification by factors of 10-100 as in AlphaFold's 2021 protein predictions, could yield therapies adding 5-10 healthy years by mid-century, though systemic biases in training data and validation needs temper expectations of doubling lifespans. Socio-technical convergence may yield hybrid human-AI systems by the 2030s, with wearable augmentations and exoskeletons enhancing physical capabilities in and contexts, as prototyped in programs achieving 2-3x load-bearing capacity. However, full transhuman convergence—merging biology with for radical enhancement—lacks feasible pathways absent breakthroughs in molecular manufacturing, historically delayed by thermodynamic and error-propagation challenges, rendering 2045 singularity timelines improbable without paradigm-shifting evidence. Feasibility critiques underscore that transhumanist goals often underestimate emergent complexities in human physiology, with past predictions like widespread cybernetic limbs unfulfilled decades after initial hype. Persistent challenges include equitable access, as biotech markets project $100 billion+ by 2030 but concentrate benefits among affluent cohorts, and like dependency on tech ecosystems.

References

  1. [1]
    Transhumanism - an overview | ScienceDirect Topics
    Transhumanism is the position that human beings should be permitted to use technology to modify and enhance human cognition and bodily function, expanding ...
  2. [2]
    Julian Huxley and Transhumanism
    The term "transhumanism" was coined by Aldous Huxley's brother, the evolutionary biologist and First Director-General of UNESCO, Julian Huxley (1887–1975):. "I ...Missing: history | Show results with:history
  3. [3]
    A Philosophical History of Transhumanism | Issue 160
    Sir Julian Sorell Huxley (1887-1975) was an English biologist, philosopher, educator, and the author of the transhumanist masterpiece, New Bottles for New Wine.
  4. [4]
    Transhumanism - Open Encyclopedia of Anthropology |
    Sep 8, 2022 · Transhumanism is a recent set of common ideals, or ideology, with the stated aim of transcending the current physical and mental limitations of ...
  5. [5]
    The Debate Over Transhumanism - Smith College
    Jun 29, 2021 · Much of the debate over transhumanism has focused on safety concerns and immoral consequences—such as increased social inequality—of the ...Missing: controversies | Show results with:controversies
  6. [6]
    An Innate Despair: The Philosophical Limitations of Transhumanism ...
    Oct 7, 2024 · Transhumanism can be defined as a project of enhancement through the application of biotechnology to move human beings beyond their natural ...
  7. [7]
    Transhumanism: Toward a Futurist Philosophy - Extropic Thoughts
    Dec 22, 2023 · This 1989 essay conveys some of the deeper philosophical and humanistic ideas behind transhumanism.
  8. [8]
    Transhumanist Values - Nick Bostrom
    Transhumanism is the study of the means and obstacles to humanity using technological and other rational means to becoming posthumans.
  9. [9]
    The Transhumanist Declaration — Humanity+
    ### Summary of the Transhumanist Declaration
  10. [10]
    A History of Transhumanist Thought - Nick Bostrom
    Transhumanists emphasize the enormous potential for genuine improvements in human well‐being and human flourishing that are attainable only via technological ...Missing: core | Show results with:core
  11. [11]
    Philsophy of Transhumanism - Humanity+
    Transhumanism continues to champion the core of the Enlightenment ideas and ideals – rationality and scientific method, individual rights, the possibility and ...
  12. [12]
    Are you a transhuman? : FM-2030. - Internet Archive
    Mar 28, 2014 · FM-2030. Publication date: 1989. Topics: Social perception., Self-evaluation. Publisher: Warner Books. Collection: internetarchivebooks; ...<|separator|>
  13. [13]
    Transhumanism Timeline – U.S. Transhumanist Party
    1850s – 1903: Nikolai Fyodorov, a philosopher, religious thinker, and futurologist, introduces Russian cosmism, a spiritual worldview that became a precursor to ...
  14. [14]
    [PDF] Transhumanism1 - Julian Huxley - Ethics in Progress
    Perhaps transhumanism will serve: man remaining man, but transcending himself, by realizing new possibilities of and for his human nature. “I believe in ...
  15. [15]
    [PDF] julian_huxley-transhumanism-in-new_bottles_for_new_wine.pdf
    Perhaps transhumanism will serve: man remaining man, but trans'" cending himself, by realizing new possibilities of and for his human nature. "I believe in ...
  16. [16]
    archives.nypl.org -- F. M. Esfandiary / FM-2030 papers
    In 1989, he published Are You a Transhuman?, a self-diagnostic test for measuring one's transhumanism. FM-2030's increasing emphasis on the physical ...
  17. [17]
    Are You a Transhuman? Monitoring and Stimulating Your Personal ...
    Rating 3.5 (46) A personal forecasting tool that lets readers determine their rate of personal growth in the rapidly changing world of the late 20th century.
  18. [18]
    Frozen For The Future: FM-2030 and Transhumanism
    Oct 12, 2022 · In transhumanism the future is key, and one of its great proponents was FM-2030. They believed in future technology, and that the past was a ...
  19. [19]
    [PDF] Transhumanism: A Futurist Philosophy | Il Dodo Pensiero
    Extropianism the principal form of transhumanism moves beyond humanism, focusing on our evolutionary future.
  20. [20]
    Max More, The Philosophy of Transhumanism - PhilPapers
    To write of “the” philosophy of transhumanism is a little daring. The growth of transhumanism as a movement and philosophy means that differing perspectives ...
  21. [21]
    What is transhumanism? - Nick Bostrom
    An important transhumanist goal is to improve the functioning of human society as an epistemic community.
  22. [22]
    Transhumanist Values - Nick Bostrom
    Outlines the core transhumanist value of exploring the posthuman realm, along with derivative values such as individual choice and diversity.
  23. [23]
    [PDF] The History of Transhumanist Thought
    Oct 19, 2004 · The World Transhumanist Association was founded in early 1998 by Nick Bostrom and. David Pearce, to provide a general organizational basis ...
  24. [24]
    Transhumanism - Ray Kurzweil And The Singularity - Science 2.0
    Sep 3, 2009 · The implications include the merger of biological and nonbiological intelligence, immortal software-based humans, and ultra-high levels of ...
  25. [25]
    The Transhuman Singularity - the Kurzweil Library
    Mar 27, 2001 · The Singularity–the point in time when machines become more intelligent than humans–in his essay, “The Technological Singularity.”
  26. [26]
    Nick Bostrom: Humanity's biggest problems aren't what ... - YouTube
    May 16, 2007 · http://www.ted.com Oxford philosopher and transhumanist Nick Bostrom examines the future of humankind and asks whether we might alter the ...
  27. [27]
    Transhumanism: Aubrey de Grey's causes of aging and how to stop ...
    Jun 18, 2018 · Dr. Aubrey de Grey is one of the leading figures in anti-aging research. He is the co-founder of SENS, a California-based research institute ...
  28. [28]
    Meet Aubrey de Grey, the Researcher Who Wants to Cure Old Age
    May 23, 2014 · The British gerontologist considers himself a “simple medical researcher,” but his research is about fiddling with cells to stop ageing in human beings.
  29. [29]
    Aubrey de Grey: Rejuvenation Technology — Will "Age" Soon ...
    Aubrey: I don't see much of a link between my work and transhumanism. I don't like to be called a transhumanist. I do very much approve of the work that people ...
  30. [30]
    Mission - Humanity+
    Humanity+ advocates for the ethical use of technology and evidence-based science to expand human capabilities. We want people to be better than well.<|control11|><|separator|>
  31. [31]
    2045 Initiative
    The XPRIZE Foundation wants to make that a reality with a $10 million competition to build robot avatars that can be controlled from at least 100 kilometers ...Project 'Immortality 2045' · All news (2278) · 2045 Initiative · About us
  32. [32]
    U.S. Transhumanist Party Platform – Organized by Subject
    The United States Transhumanist Party supports the rapid research into effective lasting cures and vaccines for COVID-19.
  33. [33]
    Do the Hallmarks of Aging Make SENS? (Part One)
    Dec 5, 2023 · Aubrey de Grey and colleagues first proposed SENS, all the aging interventions scientists had successfully used in laboratory animals ...
  34. [34]
    An age-old problem: How SENS Research Foundation is looking at ...
    Nov 8, 2023 · Dr Aubrey de Grey is co-founder of SENS Research Foundation, a not-for-profit foundation that funds innovative gerontology research.
  35. [35]
    Applications of CRISPR-Cas9 in mitigating cellular senescence and ...
    Jul 8, 2025 · This paper explores the potential of CRISPR/Cas9 as a gene-editing tool to target these mechanisms and mitigate age-related conditions.
  36. [36]
    CRISPR-Cas Genome Editing For Rejuvenation Of Aging Stem Cells
    Jul 1, 2024 · Targeting aging-related genes through CRISPR technology provides a promising strategy to combat cellular aging and extend the functional ...
  37. [37]
    Senolytics decrease senescent cells in humans - NIH
    Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease.Missing: longevity | Show results with:longevity
  38. [38]
    A pilot study of senolytics to improve cognition and mobility in older ...
    Feb 25, 2025 · This single-arm study evaluates the feasibility, safety, and preliminary effects of two senolytic agents, Dasatinib and Quercetin (DQ), ...
  39. [39]
    Senolytics target cellular senescence — but can they slow aging?
    Sep 2, 2024 · Senolytics have been found to dramatically increase lifespan in mice (by as much as 27%). And rodents treated with these drugs do not just live ...
  40. [40]
    13 anti-aging biotech companies leading longevity in 2025
    Apr 9, 2025 · In this article, we take a look at 13 anti-aging biotech companies on a mission to extend lives and make age-related diseases a thing of the past.Altos Labs · Cambrian Bio · Junevity · Juvenescence
  41. [41]
    Buck Institute for Research on Aging
    The first independent biomedical research institute in the world focused solely on aging. Our mission is to end the threat of age-related disease for this and ...Missing: major | Show results with:major
  42. [42]
    Transhumanism: Towards a new Adam? - ScienceDirect.com
    Transhumanism is possible because of the joint development of biotechnologies (biology, nanotechnologies), computer science (connectics), neurosciences ...Missing: longevity key
  43. [43]
    Transhumanism and AI: Toward Prosperity or Extinction? — EA Forum
    Mar 22, 2025 · There are three major transhumanist trends that argue for boosting human cognitive abilities in order to face artificial intelligence. The first ...<|separator|>
  44. [44]
    The present and future of neural interfaces - PMC - PubMed Central
    Oct 11, 2022 · In this perspective article, we summarize recent developments in neural interfaces, ranging from neurohybrid synapses to closed-loop BCIs.
  45. [45]
    Recent advances in neural interfaces—Materials chemistry to ...
    A brief overview of contemporary neural interfaces is presented and followed by recent progress in chemistry, materials, and fabrication techniques.
  46. [46]
    Recent advances in electrical neural interface engineering
    In this review, we present snapshots of the latest progresses in electrical neural interfaces, with an emphasis on advances that expand the spatiotemporal ...
  47. [47]
    Neuralink — Pioneering Brain Computer Interfaces
    Creating a generalized brain interface to restore autonomy to those with unmet medical needs today and unlock human potential tomorrow.Missing: transhumanism | Show results with:transhumanism
  48. [48]
    Neuralink implants brain-computer device into ninth participant
    Jul 22, 2025 · Neuralink said it implanted its brain-computer interface (BCI) device in its eighth and ninth participants over the weekend. The Elon Musk-owned ...
  49. [49]
    Neuralink Updates
    Recent Neuralink updates include the GB-PRIME study launch, $650M Series E funding, FDA Breakthrough Device Designation for Speech, and the CONVOY study launch.A Year of Telepathy · Datarepo - Neuralink's... · Neuralink raises $650 million...
  50. [50]
    Neural interfaces: Bridging the brain to the world beyond healthcare
    Neural interfaces record and decode neural signals, connecting the brain to external devices for information exchange and shared experiences.
  51. [51]
    Neuron devices: emerging prospects in neural interfaces and ...
    Dec 7, 2022 · Neuron interface devices can be used to explore the relationships between neuron firing and synaptic transmission, as well as to diagnose and treat ...
  52. [52]
    Genetic enhancement from the perspective of transhumanism
    Aug 28, 2024 · In addition to genetic enhancement, other human enhancement technologies, including brain-computer interfaces and brain uploading, are ...
  53. [53]
    Revolutionizing brain‒computer interfaces - PubMed Central - NIH
    Jul 10, 2025 · In this review, we examine the evolution of and recent advancements in neural interfaces within BCIs systems, which hold significant promise ...
  54. [54]
    The future of healthcare with medical nanorobots - ScienceDirect
    Medical nanorobots have a chance to transform healthcare by enabling better diagnostics, customized drug delivery, and less invasive surgery. Nevertheless, ...
  55. [55]
  56. [56]
    Nanorobots in Healthcare Market Size to Hit USD 13.21 Billion by ...
    Sep 26, 2025 · By type/technology, the ultrasound-driven and hybrid multifunctional nanorobots segment is set to experience the fastest CAGR 15% from 2025 to ...
  57. [57]
    Nanorobots: The Tiny Machines Revolutionizing Medicine and ...
    Mar 12, 2025 · The global nanorobots market was valued at USD 9,150 million in 2024 and is projected to grow to approximately USD 38,660 million by 2034, ...
  58. [58]
    the transformative potential of nanotechnology in medicine - PMC
    May 30, 2025 · Medical science stands on the brink of transformation thanks to nanotechnology's fast-paced development, which promises major advancements.
  59. [59]
    A New Era for Bionic Limbs - IEEE Pulse
    Mar 28, 2023 · Recent breakthroughs in science and technology have produced prosthetic hands, arms, and legs that increasingly resemble biological ones.
  60. [60]
    A prosthesis driven by the nervous system helps people ... - MIT News
    Jul 1, 2024 · A new surgical approach developed by MIT researchers enables a bionic leg driven by the body's nervous system to restore a natural walking gait ...Missing: augmentation | Show results with:augmentation
  61. [61]
    The 'mind-bending' bionic arm powered by AI - BBC
    Feb 22, 2024 · BBC Click reporter Paul Carter tries out a high-tech prosthetic promising a 'full range of human motion'.Missing: augmentation | Show results with:augmentation
  62. [62]
    Human Enhancement Technologies: 7 Examples - Peter Joosten
    Examples of human enhancement technologies include bioelectronics, senses, brain interventions, bionic, exoskeleton, genetic modification, and pharmaceuticals.<|separator|>
  63. [63]
    Emerging Medical Technologies and Their Use in Bionic Repair and ...
    Therefore, this review examines emerging, smart “bionic” materials, devices, neuroprosthetic technologies, and genetic engineering research developed to advance ...
  64. [64]
    Scientific Justification of Cryonics Practice - PMC - PubMed Central
    The scientific justification for the practice of cryonics is based on several key concepts: (1) low temperature can slow metabolism.
  65. [65]
    A Brief Scientific Introduction to Cryonics
    The status of being “dead” by present criteria has virtually the same scientific status as that of suffering from acute multiple sclerosis. You will not ...
  66. [66]
    The History of Cryonics Organizations - Tomorrow Bio 4.0
    May 12, 2023 · Let's discover the history behind the pillars of cryonics, the organizations that not only strive to provide the best possible cryopreservation services.
  67. [67]
    Human Cryostasis - The Cryonics Institute
    The cost of perpetual cryonic suspension for a Lifetime Member is $28,000 or $35,000 for Annual Members and is often funded through traditional life insurance ...Missing: rates | Show results with:rates
  68. [68]
    Cryopreservation of Animals and Cryonics: Current Technical ...
    Jun 9, 2022 · 70–90% of Neurons from autopsied geriatric humans obtained approximately 2.6 h post-mortem remained viable after two (2) weeks in vitro (55).
  69. [69]
    The False Science of Cryonics - MIT Technology Review
    Sep 15, 2015 · Reanimation or simulation is an abjectly false hope that is beyond the promise of technology and is certainly impossible with the frozen, dead tissue.
  70. [70]
    Cryonics debate: 'Many scientists are afraid to hurt their careers'
    Nov 20, 2016 · The cryobiologist Ramon Risco said scientists risked damaging their careers and being excluded from scientific societies if they worked on cryonics.
  71. [71]
    10 Terrific Transhumanist Sci-Fi Books | Book Riot
    Aug 24, 2023 · 10 Terrific Transhumanist Sci-Fi Books · Chris M. Arnone · Accelerando by Charles Stross · Frankenstein by Mary Shelley · Dawn by Octavia E. Butler.
  72. [72]
    Fictional Worlds of AI and Trans-Humanism - WRITERFUL BOOKS
    Mar 9, 2023 · Science fiction authors like Isaac Asimov, Philip K. Dick, William Gibson, and Vernor Vinge explore AI and trans-humanism in their works.<|separator|>
  73. [73]
    Transhuman Science Fiction (149 books) - Goodreads
    Transhuman Science Fiction ; 1. Accelerando ; 2. A Fire Upon the Deep (Zones of Thought, #1) ; 3. Diaspora ; 4. Permutation City ; 5. Altered Carbon (Takeshi Kovacs, ...
  74. [74]
    Transhumanism in Movies - Communication Generation
    Jun 2, 2023 · Movies explore transhumanism through cyborgs, genetic engineering, AI, and the blurring of human/machine boundaries, like in 'Blade Runner' and ...
  75. [75]
    5 of the Most Interesting Movies About Transhumanism
    Dec 5, 2018 · 5 of the Most Interesting Movies About Transhumanism · 1. Limitless (2014) · 2. Gattaca (1997) · 3. RoboCop (1987 and 2014) · 4. The Island (2005).
  76. [76]
    Ten Transhumanist Films to Watch During Your Holidays
    Nov 11, 2015 · Transhumanism is using science and technology to improve human characteristics. Films like 'Transcendence' and 'Lucy' explore this, asking how ...
  77. [77]
    'Altered Carbon' and TV's New Wave of Transhumanism | WIRED
    Feb 8, 2018 · Invasion of the Body Snatchers: Transhumanism Is Dominating Sci-Fi TV. Nobody wants these dumb meat-sack bodies anymore. Now TV is asking if ...
  78. [78]
    What are your favorite movies that touch the topic of transhumanism?
    Jul 28, 2024 · Black Mirror, The Expanse, Upload, Foundation, Peripheral, Westworld, Altered Carbon. All have either the main plot point or some side glances ...Any good Transhumanist movies : r/transhumanism - RedditAny suggestions of transhumanism related TV series? - RedditMore results from www.reddit.com
  79. [79]
    (PDF) Transhumanism, Human Enhancement and Ethical Debate
    Jun 20, 2025 · Human civilization, in different stages, has witnessed numerous religious and philosophical movements that have proposed human enhancement.
  80. [80]
    Towards a 'Culture' Utopia: Envisioning Humanity's Path.. - Medium
    Jan 22, 2024 · Banks' 'Culture' series stands out as a profound exploration of a utopian future where humanity has transcended its current limitations. This ...
  81. [81]
    DIASPORA – Greg Egan (1997) - Weighing a pig doesn't fatten it.
    May 8, 2023 · And even though parts of the physics are fictional, and Egan's brand of advanced transhumanism is a science fictional pipe dream, Diaspora ...
  82. [82]
    [PDF] ANALYZING HUMAN ENHANCEMENT IN ALDOUS HUXLEY'S ...
    May 31, 2025 · The Brave New World of Huxley can be seen as an early criticism and warning of transhumanism, which suggests that human improvement ...
  83. [83]
    Gattaca 1997 and Transhumanism 2017
    Dec 6, 2017 · Gattaca depicts a society where DNA determines social class, raising questions about ethics in technology and the line between worthy and ...
  84. [84]
    Viewing William Gibson's 'Neuromancer' Through the Lens of Trans ...
    Jun 3, 2024 · Gibson focusses on the dystopian implications of merging human consciousness with technology. While portraying the dystopian vision, Gibson ...
  85. [85]
    [PDF] Variations of Human Transformation in Science Fiction
    This is one of the important issues in SF stories which challenge readers' minds concerning human transformation. One of the key elements of transhumanism in SF ...
  86. [86]
    None
    ### Main Ethical Objections to Transhumanism by Francis Fukuyama
  87. [87]
    Ageless Bodies, Happy Souls - The New Atlantis
    A flourishing human life is not a life lived with an ageless body or untroubled soul, but rather a life lived in rhythmed time, mindful of time's limits.
  88. [88]
    The problems with transhumanism | Psychology Today
    Jul 7, 2009 · Munkittrick begins his own response to critics of transhumanism by stating that if anyone has a problem with technology addressing the issues ...Missing: controversies | Show results with:controversies
  89. [89]
    Implausibility of radical life extension in humans in the twenty-first ...
    Oct 7, 2024 · Our analysis suggests that survival to age 100 years is unlikely to exceed 15% for females and 5% for males, altogether suggesting that, unless the processes ...
  90. [90]
    Life expectancy may be reaching upper limits—for now
    Oct 21, 2024 · Q: A key line from the study concludes that “unless the process of biological aging can be slowed, radical human life extension is implausible ...Missing: empirical critiques
  91. [91]
    Inconvenient Truths About Human Longevity - Oxford Academic
    Apr 19, 2019 · In “inconvenient truths about human longevity” we lay out the line of reasoning and evidence for why there are limits to human longevity.
  92. [92]
    From Life Span to Health Span: Declaring “Victory” in the Pursuit of ...
    How far humanity can raise the life expectancy ceiling beyond the current limit is unknown. ARGUMENTS FOR AND AGAINST RADICAL LIFE EXTENSION. Scientists who ...Missing: critiques | Show results with:critiques
  93. [93]
    C&EN: COVER STORY - NANOTECHNOLOGY
    " Because Drexler sees the development of molecular assemblers and nanotechnology as inevitable, he urged society to thoroughly examine the implications of ...
  94. [94]
    The Drexler-Smalley debate on molecular assembly
    Dec 1, 2003 · Nanotechnology pioneer Eric Drexler and Rice University Professor and Nobelist Richard Smalley have engaged in a crucial debate on the feasibility of molecular ...
  95. [95]
    Spending eternity in liquid nitrogen - PMC - NIH
    Cryonicists admit they're not certain about the degree of scientific progress that will have to be made in order to reanimate corpses, or just how far away into ...
  96. [96]
    Ray Kurzweil and Uploading: Just Say No!
    Nov 1, 2011 · There is a debate about the possibility of mind-uploading – a process that purportedly transfers human minds and therefore human identities into ...
  97. [97]
    Could We One Day Upload Our Minds to a Computer?
    Feb 26, 2024 · The idea of uploading our minds to a computer sounds like the stuff of science fiction but it has also become more widespread among leading thinkers.
  98. [98]
    (PDF) Understanding the Problem of “Hype”: Exaggeration, Values ...
    I will argue that hype is best understood as a particular kind of exaggeration, one that explicitly or implicitly exaggerates various positive aspects of ...
  99. [99]
    Risk Medicine and Transhumanism - PMC - NIH
    Risk medicine, a key approach in transhumanism, aims to carry changing medical practice into a superhuman age, shaping a world that aims to perfect human ...Missing: implications | Show results with:implications
  100. [100]
    Transhumanism and inequality: Enhancing human life could bring ...
    Sep 21, 2017 · Transhumanism and inequality: Enhancing human life could bring dystopian consequences · They may enable us to enjoy greater “morphological ...
  101. [101]
    What Transhumanism Means for Our Future | Oxford Political Review
    Feb 21, 2022 · There are concerns that human enhancement could increase inequality further. For example, if the wealthiest members of society are first to gain ...
  102. [102]
    Ethical Implications of Transhumanism: The next Step in Human ...
    Aug 7, 2015 · The sociological aspect of economic inequality is consistently cited as an unavoidable negative consequence of human enhancement.
  103. [103]
  104. [104]
    [PDF] THE FUTURE OF WORK IN THE ERA OF EMERGING ...
    The future of work involves transhumanism, with possible human replacement by machines, enhancement of human capacities, and the use of emerging technologies.
  105. [105]
    Transhumanism as a positional good, economic inequality, and a ...
    Jul 12, 2024 · Many authors have indicated the potential of enhancement technologies to exacerbate the existing economic inequalities of the present. ...
  106. [106]
    The Politics and Ethics of Transhumanism - OAPEN Library
    This book interrogates the promises of transhumanism, arguing that it is deeply entwined with capitalist ideology.Missing: implications | Show results with:implications
  107. [107]
    exploring Transhumanism and its impact on human rights and the ...
    Bioconservatives argue that human enhancement would lead to social disparities, thus creating imbalances and legal inequalities. They contend that access to ...
  108. [108]
    [PDF] The Politics and Ethics of Transhumanism: Exploring Implications for ...
    This thesis critiques transhumanism, arguing it underestimates technology's complexity and is incompatible with its own values, failing to live up to them.
  109. [109]
    Transhumanism as Capitalist Continuity: Branded Bodies in the Age ...
    This ideology frames enhancement as both necessary and inevitable, concealing the political economies and asymmetries of access embedded in such narratives.
  110. [110]
    Transhumanism: What is it? and Why don't people like it? | Ethical ...
    Feb 3, 2014 · On his view, transhumanism does not advocate for creating beings that lack moral agency (or somehow transcend it), which he considers more ...
  111. [111]
    Neuralink Update, Summer 2025 - YouTube
    Jun 27, 2025 · ... neuralink.com/trials 00:00 Countdown 00:30 Intro & Overview (Elon) 12:39 Progress & Roadmap (DJ) 24:19 Our Participants (Sehej) 32:41 Robot ...
  112. [112]
    Elon Musk's Neuralink plans brain implant trial for speech impairments
    Sep 19, 2025 · The company began human trials in 2024 after addressing safety concerns raised by the FDA, which had rejected an earlier application in 2022.
  113. [113]
    Study of promising speech-enabling interface offers hope for ...
    Aug 15, 2025 · Stanford Medicine scientists have developed a brain-computer interface that detects inner speech from speech-impaired patients, in a step toward ...<|separator|>
  114. [114]
    Brain computer interfaces are poised to help people with disabilities
    Jun 30, 2025 · And in June 2025, a team at the University of California, Davis reported that a BrainGate 2 BCI allowed a man with ALS to speak through a ...
  115. [115]
    World's First Patient Treated with Personalized CRISPR Gene ...
    May 15, 2025 · In a historic medical breakthrough, a child diagnosed with a rare genetic disorder has been successfully treated with a customized CRISPR gene ...
  116. [116]
    World first: ultra-powerful CRISPR treatment trialled in a person
    May 19, 2025 · A cutting-edge gene-editing technique known as prime editing has been used to treat a person for the first time.
  117. [117]
    Brain editing now 'closer to reality': the gene-altering tools ... - Nature
    Aug 14, 2025 · Scientists are closing in on the ability to apply genome editing to a formidable new target: the human brain. In the past two years, ...
  118. [118]
    CRISPR Clinical Trials: A 2025 Update - Innovative Genomics Institute
    Jul 9, 2025 · In June 2025, Verve was acquired by Eli Lilly, with the goal of continuing to advance CRISPR-based treatments for cardiovascular disease.Blood Disorders · Cancers · Diabetes
  119. [119]
    A bionic knee integrated into tissue can restore natural movement
    Jul 10, 2025 · The new bionic knee can help people with above-the-knee amputations walk faster, climb stairs, and avoid obstacles more easily than they could with a ...Missing: enhancements | Show results with:enhancements
  120. [120]
    Feeling is believing: Bionic hand 'knows' what it's touching, grasps ...
    Mar 5, 2025 · A pioneering prosthetic hand that can grip plush toys, water bottles, and other everyday objects like a human, carefully conforming and adjusting its grasp.Missing: cybernetic enhancements<|control11|><|separator|>
  121. [121]
    Hand in bionic hand: The new age of accessible, high-tech prosthetics
    May 9, 2025 · An Osaka startup will showcase its high-tech bionic hand, replicating 95% of natural motions, at Expo 2025 Osaka, Kansai, Japan.
  122. [122]
    Making prosthetic limbs feel more real with brain-computer interfaces
    Jan 27, 2025 · UChicago scientists are making major progress on a technology designed to recreate tactile feedback to give nuanced “feeling” to prosthetic hands.Missing: cybernetic enhancements
  123. [123]
    AI pinpoints new anti-aging drug candidates | Scripps Research
    May 29, 2025 · In their new study, published in Aging Cell in May 2025, more than 70% of the anti-aging drugs identified by an AI tool significantly extended ...
  124. [124]
    Top Breakthroughs In Aging Research
    In mice, the drug rapamycin has been shown to delay the onset of Alzheimer's disease and even slow normal age-related memory decline, preserve heart function, ...
  125. [125]
    (PDF) Mind-Uploading: The Hard Problem of Transhumanism
    Key challenges include emergence, computability, functionalism, and personal identity in mind-uploading. Functionalism assumes consciousness can transfer ...Cite This Paper · Key Takeaways · References (52)<|separator|>
  126. [126]
    Why Transhumanism Won't Work - The New Atlantis
    Jun 10, 2010 · Defining a mind as a brain, to deny the possibility of mind uploading, is like defining a book as a printed text, to deny the possibility of ...
  127. [127]
    Limits to human enhancement: nature, disease, therapy or betterment?
    Oct 10, 2017 · In this article I will investigate four specific routes to limiting HE: Naturalness, disease, therapy, and betterment.Naturalness: Limits In... · Therapy Versus Enhancement · Disease As A Barrier To...
  128. [128]
    Transhumanism, medical technology and slippery slopes - PMC
    No less a figure than Francis Fukuyama recently labelled transhumanism as “the world's most dangerous idea”. Such an eye‐catching condemnation almost ...
  129. [129]
    The path to biotechnological singularity: Current breakthroughs and ...
    This review discusses recent advances in gene editing, AI-driven healthcare, regenerative medicine for enhanced longevity, synthetic biology for innovative drug ...Missing: timelines | Show results with:timelines
  130. [130]
    Rejuvenation Roundup August 2025 - Lifespan.io
    Sep 1, 2025 · Augmentation Lab Announces the Human Augmentation Summit: On August 23, the 2025 Human Augmentation Summit was a gathering of creators – from ...Missing: timelines | Show results with:timelines
  131. [131]
    AI Will Double the Human Lifespan: Here's How - Data Society
    Feb 5, 2025 · Explore how AI is revolutionizing longevity research by enhancing DNA repair, personalizing treatments, and extending healthspan—making the ...
  132. [132]
    Is Transhumanism scientifically plausible? Posthuman Predictions ...
    The plausibility of the transhumanist vision is a scientific question, not an ethical or aesthetic question.
  133. [133]
    Are you prepared to live a longer and healthier life?
    Sep 29, 2025 · ... 2025 – a 24-fold increase in just five years. Within the broader longevity ecosystem, the longevity biotech market specifically is expected ...